XIST

Summary

Gene Symbol: XIST
Description: X inactive specific transcript (non-protein coding)
Alias: DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66
Species: human
Products:     XIST

Top Publications

  1. Clemson C, McNeil J, Willard H, Lawrence J. XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol. 1996;132:259-75 pubmed
    The XIST gene is implicated in X chromosome inactivation, yet the RNA contains no apparent open reading frame. An accumulation of XIST RNA is observed near its site of transcription, the inactive X chromosome (Xi)...
  2. Chang S, Brown C. Identification of regulatory elements flanking human XIST reveals species differences. BMC Mol Biol. 2010;11:20 pubmed publisher
    ..transcriptional silencing of one X chromosome in eutherians requires transcription of the long non-coding RNA gene, XIST. Many regulatory elements have been identified downstream of the mouse Xist gene, including the antisense Tsix gene...
  3. Cohen H, Panning B. XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1. Chromosoma. 2007;116:373-83 pubmed
    ..X-inactive specific transcript (XIST) RNA is unusual among capped, spliced, polyadenylated transcripts in that it accumulates exclusively in the nucleus...
  4. Maenner S, Blaud M, Fouillen L, Savoye A, Marchand V, Dubois A, et al. 2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol. 2010;8:e1000276 pubmed publisher
    ..The 17 kb non-coding Xist RNA is crucial to this process and accumulates on the future inactive X chromosome...
  5. Pugacheva E, Tiwari V, Abdullaev Z, Vostrov A, Flanagan P, Quitschke W, et al. Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation. Hum Mol Genet. 2005;14:953-65 pubmed
    ..the future inactive X chromosome in somatic cells of female mammals involve the regulated expression of the XIST gene...
  6. Hendrich B, Plenge R, Willard H. Identification and characterization of the human XIST gene promoter: implications for models of X chromosome inactivation. Nucleic Acids Res. 1997;25:2661-71 pubmed
    The XIST gene in both humans and mice is expressed exclusively from the inactive X chromosome and is required for X chromosome inactivation to occur early in development...
  7. Hall L, Byron M, Sakai K, Carrel L, Willard H, Lawrence J. An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. Proc Natl Acad Sci U S A. 2002;99:8677-82 pubmed
    It has been believed that XIST RNA requires a discrete window in early development to initiate the series of chromatin-remodeling events that form the heterochromatic inactive X chromosome...
  8. Brown C, Ballabio A, Rupert J, Lafreniere R, Grompe M, Tonlorenzi R, et al. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature. 1991;349:38-44 pubmed
    ..This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process ..
  9. Vincent Salomon A, Ganem Elbaz C, Manie E, Raynal V, Sastre Garau X, Stoppa Lyonnet D, et al. X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors. Cancer Res. 2007;67:5134-40 pubmed
    ..In particular, it has been proposed that loss of BRCA1 function can lead to loss of X inactive-specific transcript (XIST) RNA association with the Xi...

More Information

Publications65

  1. Chow J, Hall L, Baldry S, Thorogood N, Lawrence J, Brown C. Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible. Proc Natl Acad Sci U S A. 2007;104:10104-9 pubmed
    During embryogenesis, the XIST RNA is expressed from and localizes to one X chromosome in females and induces chromosome-wide silencing...
  2. Ganesan S, Silver D, Greenberg R, Avni D, Drapkin R, Miron A, et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 2002;111:393-405 pubmed
    ..colocalizes with markers of the inactive X chromosome (Xi) on Xi in female somatic cells and associates with XIST RNA, as detected by chromatin immunoprecipitation...
  3. Wutz A. Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Nat Rev Genet. 2011;12:542-53 pubmed publisher
    ..X-chromosome inactivation is initiated in early embryogenesis by the Xist RNA that localizes to the inactive X chromosome...
  4. Brockdorff N, Ashworth A, Kay G, Cooper P, Smith S, McCabe V, et al. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature. 1991;351:329-31 pubmed
    ..The recently described human XIST gene maps to the XIC region and seems to be expressed only from the inactive X chromosome...
  5. Brown C, Hendrich B, Rupert J, Lafreniere R, Xing Y, Lawrence J, et al. The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell. 1992;71:527-42 pubmed
    ..The XIST gene is unique among X-linked genes in being expressed exclusively from the inactive X chromosome...
  6. Ganesan S, Silver D, Drapkin R, Greenberg R, Feunteun J, Livingston D. Association of BRCA1 with the inactive X chromosome and XIST RNA. Philos Trans R Soc Lond B Biol Sci. 2004;359:123-8 pubmed
    ..ChIP) experiments have demonstrated that BRCA1 physically associates with Xi-specific transcript (XIST) RNA, a non-coding RNA known to coat Xi and to participate in the initiation of its inactivation during early ..
  7. Ji B, Higa K, Kelsoe J, ZHOU X. Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders. EBioMedicine. 2015;2:909-18 pubmed publisher
    ..b>XIST and several X-linked genes were studied in 36 lymphoblastoid cell lines from healthy females and 60 lymphoblastoid ..
  8. Poplinski A, Wieacker P, Kliesch S, Gromoll J. Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. Eur J Endocrinol. 2010;162:169-75 pubmed publisher
    ..out by bisulphite sequencing of DNA from peripheral blood lymphocytes analysing X-inactive-specific transcript (XIST), phosphoglycerate kinase 1 (PGK1), ferritin, heavy peptide-like 17 (FTHL17) and short stature homeobox (SHOX)...
  9. Weakley S, Wang H, Yao Q, Chen C. Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg. 2011;35:1751-6 pubmed publisher
    X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males...
  10. Wei W, Liu Y, Lu Y, Yang B, Tang L. LncRNA XIST Promotes Pancreatic Cancer Proliferation Through miR-133a/EGFR. J Cell Biochem. 2017;118:3349-3358 pubmed publisher
    According to recent studies, long non-coding RNA X-inactive specific transcript (XIST) is involved in the development and progression of many malignant tumors including pancreatic cancer...
  11. Huang Y, Chang C, Lee S, Jou Y, Shih H. Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 2016;7:43256-43266 pubmed publisher
    ..While the X inactivate-specific transcript (Xist) lncRNA is important for X-chromosome inactivation in female cells, very little is known about the role of Xist in ..
  12. Findlay S, Postovit L. Brief Report: Common Genetic Variation in Chromosome 10 q22.1 Shows a Strong Sex Bias in Human Embryonic Stem Cell Lines and Directly Controls the Novel Alternative Splicing of Human NODAL which is Associated with XIST Expression in Female Cell Lines. Stem Cells. 2016;34:791-6 pubmed publisher
  13. Ouimette J, Rougeulle C. How Many Non-coding RNAs Does It Take to Compensate Male/Female Genetic Imbalance?. Adv Exp Med Biol. 2016;886:33-49 pubmed publisher
    ..XCI involves the concerted action of non-coding RNAs (ncRNAs), including the well-known Xist RNA, and has thus become a classical paradigm to study the mode of action of this particular class of transcripts...
  14. Schouten P, Vollebergh M, Opdam M, Jonkers M, Lodén M, Wesseling J, et al. High XIST and Low 53BP1 Expression Predict Poor Outcome after High-Dose Alkylating Chemotherapy in Patients with a BRCA1-like Breast Cancer. Mol Cancer Ther. 2016;15:190-8 pubmed publisher
    In previous studies, high expression of XIST and low expression of 53BP1 were respectively associated with poor systemic therapy outcome in patients and therapy resistance in BRCA1-deficient mouse tumor models, but have not been evaluated ..
  15. Huang Y, Hsieh H, Shih H, Sytwu H, Wu C. Urinary Xist is a potential biomarker for membranous nephropathy. Biochem Biophys Res Commun. 2014;452:415-21 pubmed publisher
    ..Using an experimental MN mouse model, we identify the first dysregulated lncRNAs, Xist and NEAT1, whose levels are significantly upregulated in both tubular epithelial and glomerular cells...
  16. Sun A, Wang J, Shan Y, Yu W, Li X, Cong C, et al. Identifying distinct candidate genes for early Parkinson's disease by analysis of gene expression in whole blood. Neuro Endocrinol Lett. 2014;35:398-404 pubmed
    ..Among 10 distinct genes which are identified in PD patients' samples, DLG1, XIST, DDX3Y and RPS4Y1 genes can classify samples into different group clearly, and they are regarded as high confidence ..
  17. Hall L, Byron M, Pageau G, Lawrence J. AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome. J Cell Biol. 2009;186:491-507 pubmed publisher
    How XIST RNA strictly localizes across the inactive X chromosome is unknown; however, prophase release of human XIST RNA provides a clue...
  18. Zhuang L, Yang Y, Ma X, Han B, Wang Z, Zhao Q, et al. MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. Cell Death Dis. 2016;7:e2203 pubmed publisher
    ..Furthermore, long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and miR-92b could directly interact with and repress each other, and XIST could inhibit HCC cell proliferation and ..
  19. Kawakami T, Okamoto K, Sugihara H, Hattori T, Reeve A, Ogawa O, et al. The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. J Urol. 2003;169:1546-52 pubmed
    ..in testicular germ cell tumor are active or inactive through a complex mechanism of X chromosomal gain and XIST expression...
  20. Chen D, Ju H, Lu Y, Chen L, Zeng Z, Zhang D, et al. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res. 2016;35:142 pubmed publisher
    ..However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown...
  21. Plenge R, Hendrich B, Schwartz C, Arena J, Naumova A, Sapienza C, et al. A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation. Nat Genet. 1997;17:353-6 pubmed
    ..Here we report a rare cytosine to guanine mutation in the XIST minimal promoter that underlies both epigenetic and functional differences between the two X chromosomes in nine ..
  22. Zhang Y, Li X, Hou Y, Fang N, You J, Zhou Q. The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancerThis article has been corrected since Advanced Online Publication, and an erratum is also printed in this issue. Acta Pharmacol Sin. 2017;38:371-381 pubmed publisher
    ..In the present study, we investigated the functional mechanisms of the lncRNA XIST in two human NSCLC cell lines, A549 and NCI-H1299...
  23. Xiong Y, Wang L, Li Y, Chen M, He W, Qi L. The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR). Cell Physiol Biochem. 2017;43:405-418 pubmed publisher
    Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA's target genes is reported to play crucial roles in malignancy...
  24. Fang J, Sun C, Gong C. Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. Biochem Biophys Res Commun. 2016;478:811-7 pubmed publisher
    ..X inactivate-specific transcript (XIST) has been found to be up-regulated and acts as an oncogene in gastric cancer and hepatocellular carcinoma, but ..
  25. Ma L, Zhou Y, Luo X, Gao H, Deng X, Jiang Y. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget. 2017;8:4125-4135 pubmed publisher
    ..LncRNA XIST expression is up-regulated in several cancers, however, its modulatory mechanism in gastric cancer (GC) has not ..
  26. Mo Y, Lu Y, Wang P, Huang S, He L, Li D, et al. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317690999 pubmed publisher
    ..Long non-coding RNA XIST expression is upregulated in several cancers; however, its modulatory mechanisms have not been reported in ..
  27. Kelsey A, Yang C, Leung D, Minks J, Dixon McDougall T, Baldry S, et al. Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST. Genome Biol. 2015;16:208 pubmed publisher
    ..inactivation is a striking example of epigenetic silencing in which expression of the long non-coding RNA XIST initiates the heterochromatinization and silencing of one of the pair of X chromosomes in mammalian females...
  28. Chang S, Chen B, Wang X, Wu K, Sun Y. Long non-coding RNA XIST regulates PTEN expression by sponging miR-181a and promotes hepatocellular carcinoma progression. BMC Cancer. 2017;17:248 pubmed publisher
    ..MiR-181a had multiple binding sites with the long non-coding RNA (lncRNA) XIST. The regulation of miR-181a on PTEN was mediated by lncRNA XIST...
  29. Tantai J, Hu D, Yang Y, Geng J. Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer. Int J Clin Exp Pathol. 2015;8:7887-95 pubmed
    Long non-coding RNAs (lncRNAs) XIST and HIF1A-AS1 have been shown to play important regulatory roles in cancer biology, and lncRNA-XIST and HIF1A-AS1 are upregulated in several cancers such as glioblastoma, breast cancer and ..
  30. Zheng R, Lin S, Guan L, Yuan H, Liu K, Liu C, et al. Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochem Biophys Res Commun. 2018;498:1002-1008 pubmed publisher
    ..The lncRNA X inactive specific transcript (XIST) is a potential tumour suppressor in some types of cancers...
  31. Brown C, Lafreniere R, Powers V, Sebastio G, Ballabio A, Pettigrew A, et al. Localization of the X inactivation centre on the human X chromosome in Xq13. Nature. 1991;349:82-4 pubmed
    ..One of the markers that defines this region is the XIST gene, which is expressed specifically from inactive, but not active, X chromosomes...
  32. Stabile M, Angelino T, Caiazzo F, Olivieri P, De Marchi N, De Petrocellis L, et al. Fertility in a i(Xq) Klinefelter patient: importance of XIST expression level determined by qRT-PCR in ruling out Klinefelter cryptic mosaicism as cause of oligozoospermia. Mol Hum Reprod. 2008;14:635-40 pubmed publisher
    ..Furthermore, we demonstrated by quantitative RT-PCR an active XIST RNA expression in blood lymphocytes from Klinefelter patients, comparable to that observed in control females and ..
  33. Sirchia S, Tabano S, Monti L, Recalcati M, Gariboldi M, Grati F, et al. Misbehaviour of XIST RNA in breast cancer cells. PLoS ONE. 2009;4:e5559 pubmed publisher
    ..In particular, the relationship between the breast cancer predisposing gene BRCA1 and XIST, the main mediator of X chromosome inactivation, has been intensely investigated, but still remains controversial...
  34. Romito A, Rougeulle C. Origin and evolution of the long non-coding genes in the X-inactivation center. Biochimie. 2011;93:1935-42 pubmed publisher
    ..that characterize the Xic landscape is the abundance of loci transcribing non-coding RNAs (ncRNAs), including Xist, the master regulator of the inactivation process...
  35. Niland C, Merry C, Khalil A. Emerging Roles for Long Non-Coding RNAs in Cancer and Neurological Disorders. Front Genet. 2012;3:25 pubmed publisher
    ..In this review, we discuss the current state of knowledge regarding the roles of lncRNAs in cancer and neurological disorders, and suggest potential future directions in this rapidly emerging field. ..
  36. Pauler F, Barlow D, Hudson Q. Mechanisms of long range silencing by imprinted macro non-coding RNAs. Curr Opin Genet Dev. 2012;22:283-9 pubmed publisher
    ..It is timely, however, to consider alternative explanations consistent with the published data, whereby transcription alone could cause gene silencing at a distance. ..
  37. Amort T, Soulière M, Wille A, Jia X, Fiegl H, Wörle H, et al. Long non-coding RNAs as targets for cytosine methylation. RNA Biol. 2013;10:1003-8 pubmed publisher
    ..Here, we demonstrate for the first time that the two well-studied regulatory long non-coding RNAs HOTAIR and XIST are targets of site-specific cytosine methylation...
  38. Chapman A, Cotton A, Kelsey A, Brown C. Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding. BMC Genet. 2014;15:89 pubmed publisher
    ..While most genes are silenced on the inactive X chromosome, the gene for the long non-coding RNA XIST is silenced on the active X chromosome and expressed from the inactive X chromosome with which the XIST RNA ..
  39. Makhlouf M, Ouimette J, Oldfield A, Navarro P, Neuillet D, Rougeulle C. A prominent and conserved role for YY1 in Xist transcriptional activation. Nat Commun. 2014;5:4878 pubmed publisher
    Accumulation of the noncoding RNA Xist on one X chromosome in female cells is a hallmark of X-chromosome inactivation (XCI) in eutherians...
  40. Fang R, Moss W, Rutenberg Schoenberg M, Simon M. Probing Xist RNA Structure in Cells Using Targeted Structure-Seq. PLoS Genet. 2015;11:e1005668 pubmed publisher
    The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells...
  41. Song P, Ye L, Zhang C, Peng T, Zhou X. Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p. Gene. 2016;592:8-14 pubmed publisher
    Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been verified as an oncogenic gene in several human malignant tumors, and its dysregulation was closed associated with tumor initiation, development and progression...
  42. Wang H, Shen Q, Zhang X, Yang C, Cui S, Sun Y, et al. The Long Non-Coding RNA XIST Controls Non-Small Cell Lung Cancer Proliferation and Invasion by Modulating miR-186-5p. Cell Physiol Biochem. 2017;41:2221-2229 pubmed publisher
    Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however, ..
  43. Patil D, Chen C, Pickering B, Chow A, Jackson C, Guttman M, et al. m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature. 2016;537:369-373 pubmed publisher
    The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome...
  44. Migeon B, Luo S, Stasiowski B, Jani M, Axelman J, Van Dyke D, et al. Deficient transcription of XIST from tiny ring X chromosomes in females with severe phenotypes. Proc Natl Acad Sci U S A. 1993;90:12025-9 pubmed
    ..The XIST locus is expressed only from the inactive X chromosome, resides at the putative X inactivation center, and is ..
  45. Harrison K. X-chromosome inactivation in the human cytotrophoblast. Cytogenet Cell Genet. 1989;52:37-41 pubmed
    ..These findings establish preferential paternal XCI in the cytotrophoblast, the cell type first to differentiate within the human blastula. ..
  46. Vasques L, Stabellini R, Xue F, Tian X, Soukoyan M, Pereira L. XIST repression in the absence of DNMT1 and DNMT3B. DNA Res. 2005;12:373-8 pubmed
    X chromosome inactivation (XCI) in human and mice involves XIST/Xist gene expression from the inactive X (Xi) and repression from the active X (Xa)...
  47. Herzing L, Romer J, Horn J, Ashworth A. Xist has properties of the X-chromosome inactivation centre. Nature. 1997;386:272-5 pubmed
    ..The Xic has been localized to a 450-kilobase region of the mouse X chromosome. The Xist gene also maps to this region and is expressed exclusively from the inactive X chromosome...
  48. Goto T, Wright E, Monk M. Paternal X-chromosome inactivation in human trophoblastic cells. Mol Hum Reprod. 1997;3:77-80 pubmed
    ..These results strongly suggest that the paternal X chromosome is preferentially inactivated in the human extra-embryonic tissues early in development. ..
  49. Brown C, Robinson W. XIST expression and X-chromosome inactivation in human preimplantation embryos. Am J Hum Genet. 1997;61:5-8 pubmed
  50. Vallot C, Patrat C, Collier A, Huret C, Casanova M, Liyakat Ali T, et al. XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. Cell Stem Cell. 2017;20:102-111 pubmed publisher
    ..RNA sequencing and imaging revealed co-activation and accumulation of the long noncoding RNAs (lncRNAs) XACT and XIST on active X chromosomes in both early human pre-implantation embryos and naive human embryonic stem cells...
  51. Daniels R, Zuccotti M, Kinis T, Serhal P, Monk M. XIST expression in human oocytes and preimplantation embryos. Am J Hum Genet. 1997;61:33-9 pubmed
    During mouse preimplantation development, the exclusive expression of the Xist gene from the paternally inherited allele is thought to play a role in the inactivation of the paternally inherited X chromosome in the extra-embryonic cell ..
  52. Chang Y, Chiu C, Yuo C, Chan W, Chang Y, Chang W, et al. An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation. Oncotarget. 2016;7:86713-86729 pubmed publisher
    X-inactive-specific transcript (XIST), a long non-coding RNA, is essential for the initiation of X-chromosome inactivation. However, little is known about other roles of XIST in the physiological process in eukaryotic cells...
  53. Hong Y, Ontiveros S, Strauss W. A revision of the human XIST gene organization and structural comparison with mouse Xist. Mamm Genome. 2000;11:220-4 pubmed
    The XIST gene plays an essential role in X Chromosome (Chr) inactivation during the early development of female humans. It is believed that the XIST gene, not encoding a protein, functions as an RNA...
  54. Kota S, Roy Chowdhury D, Rao L, Padmalatha V, Singh L, Bhadra U. Uncoupling of X-linked gene silencing from XIST binding by DICER1 and chromatin modulation on human inactive X chromosome. Chromosoma. 2015;124:249-62 pubmed publisher
    In mammals, X-inactivation process is achieved by the cis-spreading of long noncoding Xist RNA over one of the female X chromosomes...
  55. Chu C, Zhang Q, da Rocha S, Flynn R, Bharadwaj M, Calabrese J, et al. Systematic discovery of Xist RNA binding proteins. Cell. 2015;161:404-16 pubmed publisher
    ..b>Xist, an essential lncRNA for X chromosome inactivation (XCI), interacts with 81 proteins from chromatin modification, ..
  56. Yao Y, Ma J, Xue Y, Wang P, Li Z, Liu J, et al. Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152. Cancer Lett. 2015;359:75-86 pubmed publisher
    ..Here, we elucidated the function and the possible molecular mechanisms of lncRNA XIST in human glioblastoma stem cells (GSCs)...