XIAP

Summary

Gene Symbol: XIAP
Description: X-linked inhibitor of apoptosis
Alias: API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, E3 ubiquitin-protein ligase XIAP, IAP-like protein, RING-type E3 ubiquitin transferase XIAP, X-linked IAP, X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase, baculoviral IAP repeat-containing protein 4, inhibitor of apoptosis protein 3
Species: human

Top Publications

  1. ncbi Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
    Han C Dan
    Departments of Pathology and Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 279:5405-12. 2004
  2. ncbi The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
    Lakshmanan Ganesh
    Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nature 426:853-7. 2003
  3. ncbi Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis
    Zhiyin Song
    Department of Molecular and Cell Biology, Key Laboratory of Structural Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    J Biol Chem 278:23130-40. 2003
  4. ncbi Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
    Z Liu
    Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Nature 408:1004-8. 2000
  5. pmc Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
    Y Suzuki
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 98:8662-7. 2001
  6. pmc TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
    J Biol Chem 284:35906-15. 2009
  7. pmc Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP
    John C Wilkinson
    BSRB, Room 2057, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Mol Cell Biol 28:237-47. 2008
  8. doi MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells
    Shang Liu
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China
    FEBS Lett 587:2247-53. 2013
  9. ncbi Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF
    Sergio Huerta
    Department of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    J Surg Res 142:184-94. 2007
  10. pmc The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    N Roy
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 16:6914-25. 1997

Research Grants

  1. Investigation of underlying mechanisms of sex differences in cerebral ischemia
    Chad S Siegel; Fiscal Year: 2010
  2. Hermann Steller; Fiscal Year: 2016
  3. XIAP Gene Therapy in Huntington's Disease
    Michael G Kaplitt; Fiscal Year: 2013
  4. Control of Apoptosis and Signaling by XIAP
    COLIN DUCKETT; Fiscal Year: 2009
  5. Guy S Salvesen; Fiscal Year: 2016
  6. Molecular Targeting of the Survivin Pathway in Cancer
    Dario C Altieri; Fiscal Year: 2010
  7. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE-ROWLAND; Fiscal Year: 2012
  8. Cellular Determinants of Apoptosis in Virus-Infected Cells
    Ganes C Sen; Fiscal Year: 2013
  9. The role of XIAP during cold ischemia and kidney transplantation.
    ALKESH HARIHAR JANI; Fiscal Year: 2013
  10. ELIZABETH ANN EKLUND; Fiscal Year: 2016

Detail Information

Publications231 found, 100 shown here

  1. ncbi Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
    Han C Dan
    Departments of Pathology and Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 279:5405-12. 2004
    ..that Akt, including AKT1 and AKT2, interacts with and phosphorylates X-linked inhibitor of apoptosis protein (XIAP) at residue serine-87 in vitro and in vivo...
  2. ncbi The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
    Lakshmanan Ganesh
    Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nature 426:853-7. 2003
    ..Through its effects on the proteasome, Murr1 acts as a genetic restriction factor that inhibits HIV-1 replication in lymphocytes, which could contribute to the regulation of asymptomatic HIV infection and the progression of AIDS...
  3. ncbi Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis
    Zhiyin Song
    Department of Molecular and Cell Biology, Key Laboratory of Structural Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    J Biol Chem 278:23130-40. 2003
    ..We also identified that the co-presence of Smac/DIABLO and XIAP was required for Survivin to inhibit caspase cleavage in a cell-free system...
  4. ncbi Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
    Z Liu
    Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Nature 408:1004-8. 2000
    ..recognition between Smac and the IAPs, we determined the solution structure of the BIR3 domain of X-linked IAP (XIAP) complexed with a functionally active nine-residue peptide derived from the N terminus of Smac...
  5. pmc Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
    Y Suzuki
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 98:8662-7. 2001
    ..One such protein, X-linked IAP (XIAP), inhibits the activity of the cell death proteases, caspase-3, -7, and -9...
  6. pmc TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
    J Biol Chem 284:35906-15. 2009
    ..These results show that TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2...
  7. pmc Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP
    John C Wilkinson
    BSRB, Room 2057, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Mol Cell Biol 28:237-47. 2008
    X-linked inhibitor of apoptosis (XIAP) is an inhibitor of apoptotic cell death that protects cells by caspase-dependent and independent mechanisms...
  8. doi MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells
    Shang Liu
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China
    FEBS Lett 587:2247-53. 2013
    ..Furthermore, an oncogene, X-linked inhibitor of apoptosis protein (XIAP), was identified as a new target of miR-7, and the ectopic expression of XIAP rescued the effects induced by miR-7 ..
  9. ncbi Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF
    Sergio Huerta
    Department of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    J Surg Res 142:184-94. 2007
    ..In the present report, we investigated the apoptotic gene products that might account for colon cancer evasion of immune attack and chemoradioresistance-induced apoptosis...
  10. pmc The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    N Roy
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 16:6914-25. 1997
    ..Recently, we showed that one of the human IAP family proteins, XIAP, can bind to and potently inhibit specific cell death proteases (caspases) that function in the distal portions of ..
  11. ncbi Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas
    Nalan Akyurek
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:1844-51. 2006
    ..Eight IAPs have been identified in humans, of which cIAP1, cIAP2, and XIAP are well known. IAPs are being investigated as potential treatment targets in cancer patients.
  12. ncbi Immunohistochemical detection of X-linked inhibitor of apoptosis in head and neck squamous cell carcinoma
    Chandandeep Nagi
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Diagn Pathol 11:402-6. 2007
    The X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP group of structurally related caspase inhibitors...
  13. doi Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin
    Junya Kuroda
    Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Hematol 87:507-15. 2008
    ..In addition, HHT treatment resulted in reduced levels of beta-catenin and XIAP proteins, which also contribute to disease progression and resistance to chemotherapy in MM...
  14. pmc cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
    Mathieu J M Bertrand
    Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    PLoS ONE 6:e22356. 2011
    ..In this study, we found that XIAP, cIAP1 and cIAP2 not only directly bind to RIP1 and RIP2 but also to RIP3 and RIP4...
  15. pmc XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML
    Bing Z Carter
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Apoptosis 16:67-74. 2011
    b>XIAP, a potent caspase inhibitor, is highly expressed in acute myeloid leukemia (AML) cells and contributes to chemoresistance...
  16. doi XIAP as a radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinoma
    Driffa Moussata
    Service de Gastroenterologie, Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre Benite, France
    Am J Pathol 181:1271-8. 2012
    ..active caspase 3, 8, and 9 and DIABLO (direct inhibitor of apoptosis-binding protein with low pI); anti-apoptotic: XIAP (X-linked inhibitor of apoptosis)] are involved, we analyzed their profile in radioresistant (SW480) and ..
  17. ncbi X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes
    Y Suzuki
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    J Biol Chem 276:27058-63. 2001
    ..Binding assays revealed that the inhibition of caspase-3 by XIAP was totally dependent on the interaction between the active site of caspase-3 and the linker region between the ..
  18. ncbi Mechanism of XIAP-mediated inhibition of caspase-9
    Eric N Shiozaki
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 11:519-27. 2003
    ..reports the crystal structure of caspase-9 in an inhibitory complex with the third baculoviral IAP repeat (BIR3) of XIAP at 2.4 A resolution. The structure reveals that the BIR3 domain forms a heterodimer with a caspase-9 monomer...
  19. ncbi Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein
    Jian Fu
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 278:52660-72. 2003
    X-linked inhibitor of apoptosis protein (XIAP), the most potent member of the inhibitor of apoptosis protein (IAP) family, plays a crucial role in the regulation of apoptosis...
  20. ncbi Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation
    Ming Tsan Lin
    Department of Surgery, National Taiwan University Hospital, Taipei
    J Biol Chem 279:24015-23. 2004
    ..In addition, several NF-kappaB-regulated anti-apoptotic genes were examined, and we found that only XIAP showed a significant 3-4-fold increase in mRNA and protein in Cyr61-overexpressing cells but not in neo control ..
  21. ncbi X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia
    Xiaoyang Wang
    Department of Neuroscience, Neurobiology, Uppsala University, Uppsala, SE 751 23, Sweden
    Neurobiol Dis 16:179-89. 2004
    Nine-day-old transgenic XIAP overexpressing (TG-XIAP) and wild-type mice were subjected to left carotid artery ligation and 10% O(2) for 60 min, leading to widespread infarctions in the ipsilateral hemisphere during reperfusion...
  22. ncbi Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines
    Guoxiong Xu
    Department of Biology, York University, 4700 Keel Street, Toronto, Ontario, Canada M3J 1P3
    Mol Cancer Res 4:235-46. 2006
    ..the expression of proapoptotic factor Bax but suppressed the expression of antiapoptotic factors Bcl-2, Bcl-XL, and Xiap. Silencing of Bax by small interfering RNA in IOSE397 cells significantly reduced ALK7-ca-induced apoptosis as ..
  23. ncbi A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO
    Allison M Hunter
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario, Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    J Biol Chem 278:7494-9. 2003
    ..The ability to circumvent the requirement for mitochondrial processing and release is critical to developing Smac as a possible gene therapy payload in cancer chemosensitization...
  24. ncbi Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis
    V Galvan
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    FEBS Lett 558:57-62. 2004
    We report here that the checkpoint kinase Chk1 and the inhibitor of apoptosis protein (IAP) family member XIAP can be found in a complex in association with condensed chromosomes aligned at the metaphase plate during mitosis...
  25. pmc IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis
    Mads Gyrd-Hansen
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 10:1309-17. 2008
    ..Moreover, the UBA domain is required for XIAP and cIAP2-MALT1 to activate NF-kappaB...
  26. doi Molecular interaction between HAX-1 and XIAP inhibits apoptosis
    Young Ji Kang
    Medical Proteomics Research Center, KRIBB, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 393:794-9. 2010
    ..Through immunoprecipitation and 2D gel electrophoresis, we identified X-linked inhibitor of apoptosis protein (XIAP) as a novel HAX-1-interacting protein...
  27. ncbi Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
    Y Huang
    Program in Physiology, Biophysics and Molecular Medicine, Graduate School of Medical Sciences, of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cell 104:781-90. 2001
    ..Here, we report the crystal structure of the complex between human caspase-7 and XIAP (BIR2 and the proceeding linker)...
  28. ncbi Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
    Till Bartke
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell 14:801-11. 2004
    ..Our work suggests that, owing to its two activities and its localization, BRUCE may function as a specialized regulator of cell death pathways...
  29. pmc Upstream regulatory role for XIAP in receptor-mediated apoptosis
    John C Wilkinson
    Departments of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 24:7003-14. 2004
    X-linked inhibitor of apoptosis (XIAP) is an endogenous inhibitor of cell death that functions by suppressing caspases 3, 7, and 9...
  30. ncbi Che-1 activates XIAP expression in response to DNA damage
    T Bruno
    Laboratory B, Department of Therapeutic Programs Development, Regina Elena Cancer Institute, Rome, Italy
    Cell Death Differ 15:515-20. 2008
    X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family that selectively binds and inhibits caspase-3, -7 and -9...
  31. ncbi Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein
    Håkan Steen
    Department of Neuroscience, Uppsala University, Biomedical Centre, Box 587, Husargatan 3, SE 75123 Uppsala, Sweden
    Biochem Biophys Res Commun 366:432-7. 2008
    ..Nulp1 binds the X-linked inhibitor of apoptosis protein (XIAP) and this interaction was increased during cell death...
  32. doi X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis
    Celine Van Themsche
    Research Group in Molecular Oncology and Endocrinology, Department of Chemistry and Biology, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada G9A 5H7
    Endocrinology 149:3789-98. 2008
    ..apoptosis in endometrial carcinoma cells, and examined a putative role for X-linked inhibitor of apoptosis protein (XIAP) in regulating cellular sensitivity to the cytokine...
  33. pmc Impact of XIAP protein levels on the survival of myeloma cells
    Grégoire Desplanques
    INSERM, UMR 892, Nantes, France
    Haematologica 94:87-93. 2009
    b>XIAP is the best characterized and the most potent direct endogenous caspase inhibitor and is considered a key actor in the control of apoptotic threshold in cancer cells...
  34. doi p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies
    Seung Woo Hong
    Department of Anatomy and Tumor Immunity Medical Research Center, Division of Biological Sciences, Seoul National University College of Medicine, Sookmyung Women s University, Seoul, Korea
    Cancer Res 69:741-6. 2009
    ..function of p34(SEI-1) increases tumor cell survival by protecting the X-linked inhibitor of apoptosis protein (XIAP) from degradation. Our findings show that p34(SEI-1) inhibits apoptosis...
  35. ncbi Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cells
    Dandan Song
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
    Cancer Biol Ther 9:96-108. 2010
    ..analyses revealed that CDODO-Me-12 and CDODO-Me-11 downregulated the levels of anti-apoptosis proteins, c-FLIP, XIAP and Mcl-1, without altering the protein levels of Bcl-2 and the death receptors DR4 and DR5...
  36. ncbi X-linked IAP is a direct inhibitor of cell-death proteases
    Q L Deveraux
    The Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA
    Nature 388:300-4. 1997
    ....
  37. pmc IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    Q L Deveraux
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 17:2215-23. 1998
    ..Human XIAP, cIAP1 and cIAP2 are direct inhibitors of at least two members of the caspase family of cell death proteases: ..
  38. ncbi A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
    S M Srinivasula
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 410:112-6. 2001
    X-linked inhibitor-of-apoptosis protein (XIAP) interacts with caspase-9 and inhibits its activity, whereas Smac (also known as DIABLO) relieves this inhibition through interaction with XIAP...
  39. ncbi The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
    L Miguel Martins
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 277:439-44. 2002
    ..Here we have identified the serine protease Omi/HtrA2 as a second mammalian XIAP-binding protein with a Reaper-like motif...
  40. pmc Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein
    Hwain Shin
    The Program in Apoptosis and Cell Death Research, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 373:965-71. 2003
    ..We demonstrate that the auto-ubiquitination sites of the X-linked IAP (XIAP) are Lys(322) and Lys(328), located in the third baculovirus IAP repeat domain of the protein...
  41. ncbi Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 12:705-8. 2003
    The X-linked inhibitor of apoptosis (XIAP) is a member of a novel family of inhibitors of apoptosis...
  42. ncbi Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis
    John Silke
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
    J Biol Chem 279:4313-21. 2004
    ..Although they have the same IAP binding specificity, only Grim promoted XIAP ubiquitination and degradation...
  43. ncbi Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus
    Daniel Nowak
    Department of Internal Medicine III, Hematology and Oncology, University Hospital Frankfurt, Theodor SternKai 7, 60590 Frankfurt am Main, Germany
    Leuk Lymphoma 45:1429-36. 2004
    The X-linked inhibitor of apoptosis (XIAP) and cellular inhibitor of apoptosis-1 (cIAP-1) are emerging as versatile proteins in programmed cell death with a scope of possible functions reaching far beyond their well known inhibitory ..
  44. ncbi IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
    Tencho Tenev
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 7:70-7. 2005
    ..Whereas XIAP binds directly to the active-site pockets of effector caspases, we find that regulation of effector caspases by ..
  45. pmc Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein
    Markus Rehm
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    EMBO J 25:4338-49. 2006
    ..a critical role for caspase-3-dependent feedback signalling and the X-linked-inhibitor-of-apoptosis-protein (XIAP), but a less prominent role for the XIAP antagonist Smac...
  46. ncbi XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome
    Stéphanie Rigaud
    Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Univ René Descartes, Paris, F 75015, France
    Nature 444:110-4. 2006
    ..Here, we identify mutations in the gene that encodes the X-linked inhibitor-of-apoptosis XIAP (also termed BIRC4) in patients with XLP from three families without mutations in SAP...
  47. pmc XIAP: cell death regulation meets copper homeostasis
    Arjmand R Mufti
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Arch Biochem Biophys 463:168-74. 2007
    X-linked inhibitor of apoptosis (XIAP), traditionally known as an anti-apoptotic protein, has recently been shown to be involved in copper homeostasis...
  48. ncbi Immunohistochemical detection of X-linked inhibitor of apoptosis (XIAP) in neoplastic and other thyroid disorders
    Guang Qian Xiao
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Diagn Pathol 11:235-40. 2007
    The X-linked inhibitor of apoptosis (XIAP) is the most potent of the inhibitors of apoptosis, a group of related caspase inhibitors...
  49. pmc Crystal structure of the BIR1 domain of XIAP in two crystal forms
    Su Chang Lin
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Mol Biol 372:847-54. 2007
    X-linked inhibitor of apoptosis (XIAP) is a potent negative regulator of apoptosis. It also plays a role in BMP signaling, TGF-beta signaling, and copper homeostasis...
  50. ncbi Identification of polymorphisms in the XIAP gene and analysis of association with lung cancer risk in a Korean population
    Hyo Gyoung Kang
    Cancer Research Institute, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu, 700 422, Republic of Korea
    Cancer Genet Cytogenet 180:6-13. 2008
    The X-linked inhibitor of apoptosis protein (XIAP) is a potent mammalian IAP, and has been shown to play an important role in development and progression of cancer...
  51. ncbi Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol
    Veronique Gagnon
    Department of Chemistry and Biology, Medical Biology Section, University of Quebec at Trois Rivieres, CP 500, Trois Rivieres, QC, Canada, G9A 5H7
    Apoptosis 13:259-71. 2008
    We have investigated the interrelationship between two anti-apoptotic factors, XIAP and Akt, and their role in chemoresistance of uterine cancer cells...
  52. doi BRAFV600E mutation and X-linked inhibitor of apoptosis expression in papillary thyroid carcinoma
    Li Qun Gu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Thyroid 19:347-54. 2009
    ..genetic alteration in papillary thyroid carcinoma (PTC), while overexpression of X-linked inhibitor of apoptosis (XIAP) has been found in various tumors...
  53. pmc X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
    Celine Van Themsche
    Department of Chemistry Biology, University of Quebec, Trois Rivieres, Quebec G9A 5H7, Canada
    J Biol Chem 284:20462-6. 2009
    ..The phosphorylation of Akt has previously been shown to be promoted by X-linked inhibitor of apoptosis protein (XIAP), another antiapoptotic protein dictating the fate of normal and cancer cells...
  54. pmc X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 284:34553-60. 2009
    ..However, knockdown of X chromosome-linked IAP (XIAP) or antagonism of XIAP allows FasL or DR5 agonist antibody to induce activation of effector caspases efficiently ..
  55. pmc XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling
    Celine Van Themsche
    Research Group in Molecular Oncology and Endocrinology, Department of Chemistry Biology, University of Quebec at Trois Rivieres, Trois Rivieres, Quebec, Canada
    Mol Cancer 9:216. 2010
    X-linked inhibitor of apoptosis protein (XIAP) is often overexpressed in cancer cells, where it plays a key role in survival and also promotes invasiveness...
  56. doi Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)
    Jana Pachlopnik Schmid
    INSERM Unité 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Blood 117:1522-9. 2011
    ..XLP type 1 (XLP-1) is caused by mutations in the gene SH2D1A (also named SAP), whereas mutations in the gene XIAP underlie XLP type 2 (XLP-2)...
  57. pmc X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton
    Jinyi Liu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 286:15630-40. 2011
    X-linked inhibitor of apoptosis protein (XIAP) overexpression has been found to be associated with malignant cancer progression and aggression in individuals with many types of cancers...
  58. pmc Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription
    Jessy Cartier
    Institut National de la Santé et de la Recherche Médicale UMR866, Dijon, F 21079, France
    J Biol Chem 286:26406-17. 2011
    ..This function is not conserved for cIAP2 and XIAP, which are cytoplasmic proteins...
  59. pmc The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP
    Yong Fang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 287:35234-43. 2012
    ..by marked apoptotic induction as well as down-regulation of the X-linked inhibitor of apoptosis protein (XIAP)...
  60. doi Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase
    Yoshio Nakatani
    Biochemistry Department, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    Biochem J 450:629-38. 2013
    ..that E2 conjugated ubiquitin contacts the RING homodimer interface of the IAP (inhibitor of apoptosis) proteins, XIAP (X-linked IAP) and cIAP (cellular IAP) 2...
  61. ncbi Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
    P Liston
    Molecular Genetics Research Laboratory, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Nature 379:349-53. 1996
    ..The human iap genes have a distinct but overlapping pattern of expression in fetal and adult tissues. These proteins significantly increase the number of known apoptotic suppressors...
  62. pmc A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
    C S Duckett
    Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
    EMBO J 15:2685-94. 1996
    ..Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis...
  63. ncbi A single BIR domain of XIAP sufficient for inhibiting caspases
    R Takahashi
    Burnham Institute, Program on Apoptosis and Cell Death Regulation, La Jolla, California 92037, USA
    J Biol Chem 273:7787-90. 1998
    ..Some IAP family proteins, including XIAP, cIAP-1, and cIAP-2, can bind and directly inhibit selected caspases, a group of intracellular cell death proteases...
  64. pmc XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
    K Yamaguchi
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya, Japan
    EMBO J 18:179-87. 1999
    ..The human X-chromosome-linked inhibitor of apoptosis protein (XIAP) was isolated as a TAB1-binding protein...
  65. ncbi Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    A M Verhagen
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Cell 102:43-53. 2000
    To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we used coimmuno-precipitation and 2D immobilized pH gradient/SDS PAGE, followed by electrospray ionization tandem mass spectrometry...
  66. ncbi Identification of XAF1 as an antagonist of XIAP anti-Caspase activity
    P Liston
    Cancer Research Group, Ottawa Regional Cancer Center, 501 Smyth Road, Ottawa, K1H 8L6, Canada
    Nat Cell Biol 3:128-33. 2001
    ..Here we have isolated the protein XIAP-associated factor 1 (XAF1) on the basis of its ability to bind XIAP, a member of the IAP family...
  67. ncbi Structural basis of caspase-7 inhibition by XIAP
    J Chai
    Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA
    Cell 104:769-80. 2001
    ..Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution...
  68. ncbi Structural basis for the inhibition of caspase-3 by XIAP
    S J Riedl
    The Program in Apoptosis and Cell, Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 104:791-800. 2001
    ..The main endogenous inhibitors are members of the IAP family and are exemplified by XIAP, which regulates the initiator caspase-9, and the executioner caspases-3 and -7...
  69. ncbi X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling
    S Birkey Reffey
    Metabolism Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:26542-9. 2001
    X-linked inhibitor of apoptosis protein (XIAP) is a potent suppressor of apoptotic cell death, which functions by directly inhibiting caspases, the principal effectors of apoptosis...
  70. ncbi HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    Anne M Verhagen
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 277:445-54. 2002
    ..that HtrA2, a mammalian homologue of the Escherichia coli heat shock-inducible protein HtrA, can bind to MIHA/XIAP, MIHB, and baculoviral OpIAP but not survivin...
  71. ncbi Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants
    Tina M Sauerwald
    Department of Chemical Engineering, The Johns Hopkins University, 3400 North Charles St, Baltimore, Maryland 21218, USA
    Biotechnol Bioeng 77:704-16. 2002
    ..b>XIAP is the most potent caspase inhibitor encoded in the mammalian genome...
  72. pmc Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition
    Christopher L Holley
    C370 LSRC, Research Drive, Box 3813, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Cell Biol 4:439-44. 2002
    ....
  73. ncbi Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro
    Marion MacFarlane
    Medical Research Council Toxicology Unit, Hodgkin Building, University of Leicester, P O Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 277:36611-6. 2002
    ..As the RING finger domain of XIAP possesses ubiquitin-protein ligase activity and XIAP binds tightly to mature Smac, an in vitro ubiquitination assay ..
  74. ncbi Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia
    Susumu Kobayashi
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 277:33968-77. 2002
    ..Here, we found that calpains cleave the X-linked inhibitor of apoptosis (XIAP) in vitro, producing fragments that are unable to inhibit caspase-3...
  75. pmc The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2
    Martin Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Mol Cell Biol 23:280-8. 2003
    The X-chromosome-linked inhibitor of apoptosis, XIAP, is the most powerful and ubiquitous intrinsic inhibitor of apoptosis...
  76. ncbi Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO
    Shimin Hu
    Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 278:10055-60. 2003
    ..These results suggest a novel and conserved mechanism by which IAPs block apoptosis through the degradation of death inducers...
  77. pmc Cisplatin resistance in an ovarian carcinoma is associated with a defect in programmed cell death control through XIAP regulation
    Abdellah Mansouri
    Department of Molecular Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Oncol Res 13:399-404. 2003
    ..CDDP) treatment, we compared the effect of CDDP on expression of X-linked inhibitor of apoptosis protein (XIAP), a direct inhibitor of caspase-3, -7, and -9, Fas, Fas-ligand (Fas-L), and pro- and antiapoptotic proteins in a ..
  78. ncbi Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo
    YanPing Hu
    Department of Advanced Therapeutics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 9:2826-36. 2003
    ..X-linked inhibitor of apoptosis (XIAP), is the most potent member of the IAP gene family in terms of its ability to inhibit caspases and suppress ..
  79. ncbi Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac
    Yihua Huang
    Department of Biochemistry, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    J Biol Chem 278:49517-22. 2003
    ..X-linked IAP (XIAP) contains three BIR domains and directly inhibits effector caspases such as caspase-7 via a linker_BIR2 fragment ..
  80. pmc A novel role for XIAP in copper homeostasis through regulation of MURR1
    Ezra Burstein
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    EMBO J 23:244-54. 2004
    b>XIAP is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases. Here we demonstrate a novel role for XIAP in the control of intracellular copper levels...
  81. ncbi High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
    Ingo Tamm
    Department of Hematology, Oncology, and Tumor Immunology, Charite, Campus Berlin Buch, Universitatsmedizin Berlin, Berlin, Germany
    Clin Cancer Res 10:3737-44. 2004
    ..Apoptosis-related proteins are important molecules for predicting chemotherapy response and prognosis in adult acute myeloid leukemia (AML). However, data on the expression and prognostic impact of these molecules in childhood AML are rare...
  82. ncbi An IAP-IAP complex inhibits apoptosis
    Takehiko Dohi
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Biol Chem 279:34087-90. 2004
    ..survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats...
  83. ncbi XIAP expression is an independent prognostic marker in clear-cell renal carcinomas
    Uwe Ramp
    Institute of Pathology, University Hospital, Dusseldorf, Germany
    Hum Pathol 35:1022-8. 2004
    ..b>XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members...
  84. ncbi Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
    Yanyan Hao
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 6:849-60. 2004
    ..Furthermore, the IAP-binding motif of SMAC was required to induce apoptosis in Apollon-deficient cells. These results suggest that Apollon has an essential function in preventing SMAC-induced apoptosis...
  85. pmc XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
    Fiona L Scott
    Program in Apoptosis and Cell Death Research, The Burnham Institute, La Jolla, CA 92037, USA
    EMBO J 24:645-55. 2005
    The X-linked inhibitor of apoptosis protein (XIAP) uses its second baculovirus IAP repeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7...
  86. ncbi cIAP1 Localizes to the nuclear compartment and modulates the cell cycle
    Temesgen Samuel
    Burnham Institute, La Jolla, CA 92037, USA
    Cancer Res 65:210-8. 2005
    ..Unlike family member X-linked IAP (XIAP), which was predominantly cytoplasmic, the cIAP1 protein localized almost exclusively to nuclei in cells, as ..
  87. ncbi X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO
    Yoshihito Morizane
    Division of Molecular Biology, School of Life Science, Tokyo University of Pharmacy, and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392
    J Biochem 137:125-32. 2005
    ..Here we show that X-linked IAP (XIAP) mediates the polyubiquitination of caspase-9 and Smac...
  88. pmc Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16182-7. 2005
    ..Cross control of protein levels by RING domains may therefore enable their levels to be manipulated therapeutically...
  89. pmc Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP
    Malia B Potts
    Neuroscience Center, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 171:925-30. 2005
    Overexpression studies have identified X-linked inhibitor of apoptosis protein (XIAP) as a potent inhibitor of caspases. However, the exact function of endogenous XIAP in regulating mammalian apoptosis is less clear...
  90. ncbi siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status
    Ken Ohnishi
    Department of Biology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Radiat Res 166:454-62. 2006
    ..In addition, radiation-induced expression of the transcription factor NF-kappaB (NFKB) and XIAP (X-chromosome-linked inhibitor of apoptosis protein) was suppressed by NBS1-siRNA...
  91. pmc Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
    Brendan P Eckelman
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    EMBO Rep 7:988-94. 2006
    ..The most intensively studied family member, X-linked IAP (XIAP), is a potent inhibitor of caspase activity; hence, it is generally assumed that direct caspase inhibition is an ..
  92. ncbi Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library
    Michael C Sweeney
    Ohio State Biochemistry Program, Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:14740-8. 2006
    ..The X-chromosome-linked IAP (XIAP) contains three baculovirus IAP repeat (BIR) domains, which bind directly to the N-termini of target proteins ..
  93. pmc Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation
    Wen Hsien Liu
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC
    EMBO J 26:1660-9. 2007
    ..intracellular domain could partly be attributed to a selective increase of X-linked inhibitor of apoptosis protein (XIAP). We further found that Notch intracellular domain inhibited the degradation of XIAP during apoptosis...
  94. ncbi Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas
    Tomotaka Shibata
    Institute of Pathology, Heinrich Heine University Hospital, Duesseldorf, Germany
    Diagn Mol Pathol 16:1-8. 2007
    ..Whereas x-linked inhibitor of apoptosis (XIAP) is a potent inhibitor of apoptosis, its antagonists second mitochondria-derived activator of caspases/direct IAP ..
  95. ncbi XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics
    Shuguang Zhang
    Department of Thoracic Surgery, The First Affiliated Hospital, China Medical University, Shenyang, China
    Cancer Biol Ther 6:973-80. 2007
    X-linked inhibitor of apoptosis protein (XIAP) is the most potent member of the IAP gene family in terms of its ability to inhibit caspases and suppress apoptosis...
  96. ncbi Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence
    David B Seligson
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California 90095 1747, USA
    Clin Cancer Res 13:6056-63. 2007
    The X-linked inhibitor of apoptosis protein (XIAP) is associated with cell survival by blocking caspase-mediated apoptosis...
  97. ncbi IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    Cell 131:669-81. 2007
    ..Through their ubiquitin E3 ligase activities c-IAP1 and c-IAP2 promote proteasomal degradation of NIK, the central ser/thr kinase in the noncanonical NF-kappaB pathway...
  98. ncbi IAPs: more than just inhibitors of apoptosis proteins
    Laurence Dubrez-Daloz
    INSERM, UMR 866, Institut Fédératif de Recherche IFR Santé STIC, University of Burgundy, Dijon, France
    Cell Cycle 7:1036-46. 2008
    ..In mammals, BIRC4/XIAP, the most studied IAP member can directly inhibit the activity of caspase-3, 7 and 9...
  99. doi A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma
    O Ndozangue-Touriguine
    Faculte de Pharmacie, INSERM U749, Chatenay Malabry, Hauts de Seine, France
    Oncogene 27:6012-22. 2008
    ..that, in contrast to SW480 cells, the SW620 cell line expresses high amounts of X-linked inhibitor of apoptosis (XIAP)...
  100. doi cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    Mathieu J M Bertrand
    Montreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada
    Mol Cell 30:689-700. 2008
    ..When deubiquitinated by AEG40730 treatment, RIP1 binds caspase-8 and induces apoptosis. These findings provide insights into the function of the IAPs and provide new therapeutic opportunities in the treatment of cancer...
  101. doi Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein
    Carla L O'Connor
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Biochim Biophys Acta 1783:1903-13. 2008
    X-linked-inhibitor-of-apoptosis-protein (XIAP) is the most potent intracellular inhibitor of caspases-9, -3 and -7...

Research Grants63

  1. Investigation of underlying mechanisms of sex differences in cerebral ischemia
    Chad S Siegel; Fiscal Year: 2010
    ..We will investigate the role of caspase-mediated cell death proteins (XIAP, Apaf-1, Smac/DIABLO, caspases, and cyt-c) in both male and female mice after experimental stroke...
  2. Hermann Steller; Fiscal Year: 2016
    ..We will also investigate the mechanism by which mouse XIAP inhibits caspases, and study the role of this protein in apoptosis and tumor suppression in vivo by taking ..
  3. XIAP Gene Therapy in Huntington's Disease
    Michael G Kaplitt; Fiscal Year: 2013
    ..X-linked inhibitor of apoptosis (XIAP) is the most potent member of a family of apoptosis inhibitor proteins, which is known to bind to and block the ..
  4. Control of Apoptosis and Signaling by XIAP
    COLIN DUCKETT; Fiscal Year: 2009
    Expression of the X-linked inhibitor of apoptosis (XIAP) is greatly enhanced in many classes of malignancy, and strategies to suppress XIAP function are showing great promise in the treatment of cancer...
  5. Guy S Salvesen; Fiscal Year: 2016
    ..IAP family members XIAP, c-IAP1, and c-IAP2 are E3 ligases, catalyzing formation of polyubiquitin chains on substrates involving either ..
  6. Molecular Targeting of the Survivin Pathway in Cancer
    Dario C Altieri; Fiscal Year: 2010
    ..In turn, mitochondria-derived survivin forms a complex with IAP family protein, XIAP, and this has broad cytoprotective consequences with intrinsic inhibition of apoptosis, activation of gene ..
  7. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE-ROWLAND; Fiscal Year: 2012
    ..characteristics will be modified to deliver corrective (RetGC1), anti-apoptotic (X-linked inhibitor of apoptosis, XIAP), and neurotrophic (rod derived cone viability factor, RdCVF;glial-derived neurotrophic factor, GDNF) therapies...
  8. Cellular Determinants of Apoptosis in Virus-Infected Cells
    Ganes C Sen; Fiscal Year: 2013
    ..RIPA is temporally regulated through the action of XIAP and PI3 kinase, which is also activated upon virus infection...
  9. The role of XIAP during cold ischemia and kidney transplantation.
    ALKESH HARIHAR JANI; Fiscal Year: 2013
    ..hibernating 13-lined ground squirrels is associated with upregulation of X-linked inhibitor of apoptosis protein (XIAP). This led us to measure XIAP in mice and pig kidneys subjected to CI...
  10. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..Gas2 inhibits calpain;a serine protease with substrates that include bcate-nin, Stat3, Stat5 and Xiap. We found a Gas2-dependent decrease in calpain activity and increase in bcatenin in Bcr-abl+ or Icsbp-/- murine ..
  11. Shaomeng Wang; Fiscal Year: 2014
    ..IAP-2 (cIAP-2) play critical roles in the regulation of death-receptor-mediated apoptosis, and X-linked IAP (XIAP) is a central regulator of both death-receptor-mediated and mitochondria-mediated apoptosis pathways...
  12. Jennifer D Black; Fiscal Year: 2016
    ..Survivin/XIAP complexes that mediate caspase inhibition have been shown to be a key cell survival mechanism for supporting the ..
  13. William G Hawkins; Fiscal Year: 2016
    ..b>XIAP is a key molecule for the inhibition of apoptosis by blocking the activation of caspases-3/7 and caspase-9...
  14. Mechanisms of Increasing Apoptosis Regulation in Developing and Mature Neurons
    Mohanish Deshmukh; Fiscal Year: 2011
    ..we find that caspase activation in neurons during early development is strictly and selectively regulated by XIAP. In Specific Aim 1, we will examine how XIAP's strict control of caspases is overcome to permit caspase ..
  15. Bethany B Moore; Fiscal Year: 2016
    ..survival via the induction of the anti- apoptotic proteins (survivin, X-linked inhibitor of apoptosis (XIAP) and Bcl-2)...
  16. Molecular intersection between neuronal apoptosis and axon degeneration
    COREY CUSACK; Fiscal Year: 2013
    ..This aim will also test the hypothesis that XIAP, an endogenous inhibitor of caspases, protects the neuronal cell body by restricting caspase activity to the axon ..
  17. Proteasome/HDAC Inhibition in Leukemia/MDS; Phase I Trial and Correlative Studies
    Steven Grant; Fiscal Year: 2010
    ..inhibition of HDACI-induced NF-:B activation, down-regulation of NF-:B-dependent anti-apoptotic proteins (Bcl-xL, XIAP), HDACI-mediated up-regulation of Bim, and disruption of aggresome function...
  18. Phase I Trial of Bortezomib and Romidepsin in CLL and Small Cell Lymphoma
    Steven Grant; Fiscal Year: 2010
    ..g., Bcl-xL and XIAP). Very recently, we have observed that when co-administered in vitro at extremely low concentrations (i.e...
  19. CYSTEINE PROTEASES IN APOPTOSIS AND CANCER
    EMAD ALNEMRI; Fiscal Year: 2005
    ..and pro-apoptotic Bcl-2 family members, interactions of Smac with IAPs and detailed analysis of the interaction of XIAP and Smac/DIABLO with the Apaf-l-caspase-9 apoptosome...
  20. Translational Control of Radiation-Induced Apoptosis
    Alexey G Ryazanov; Fiscal Year: 2012
    ..In our preliminary experiments we found that downregulation of anti-apoptotic proteins FLIP and XIAP is blocked in cells lacking eEF2K, suggesting that phosphorylation of eEF2 by eEF2K stimulates radiation-induced ..
  21. Ethan Lee; Fiscal Year: 2016
    ..a screen for ubiquitin E3 ligases and deubiquitinating enzymes that identified X-linked inhibitor of apoptosis (XIAP) and USP47, respectively, as essential mediators of Wnt signaling...
  22. Gregory J Gores; Fiscal Year: 2016
    ..preliminary data demonstrating that the Hedgehog signaling pathway upregulates X-linked inhibitor of apoptosis (XIAP) endowing CCA cells with anti-TRAIL survival signals...
  23. Michael G Brattain; Fiscal Year: 2014
    ..activation of PKA (independent of cAMP, but AKAP dependent) that leads to proteosomal degradation of survivin and XIAP. These IAPs have been shown to be critical to aberrant cell survival signaling in tumor models (Dohi et al, 2007)...
  24. Design of Bivalent SMAC Mimetics
    Shaomeng Wang; Fiscal Year: 2013
    ..Based on high-resolution three-dimensional structures of Smac protein and peptide in complex with X-linked IAP (XIAP), we have recently designed and synthesized a class of potent, non-peptide, cell-permeable, small- molecule Smac ..
  25. NF-kappaB Inhibitors and Differentiation-Inducers in Leukemia
    Steven Grant; Fiscal Year: 2011
    ..inhibitor flavopiridol triggered multiple perturbations in leukemia cells, including down-regulation of p21CIP1, XIAP, Mcl-1, and NF-kappaB, that collectively blocked HDACI-mediated maturation and reciprocally potentiated apoptosis, ..
  26. Lee Ann H Allen; Fiscal Year: 2016
    ..To elucidate the molecular mechanisms of apoptosis inhibition by F. tularensis with a focus on the BAX, XIAP and calpastatin. 2. To identify bacterial genes required for PMN apoptosis inhibition. 3...
  27. ROCK inhibitor suppression of GVHD with retention of GVL response
    Sujatha Iyengar; Fiscal Year: 2012
    ..Three small molecule ROCK inhibitors will be tested in MHC and minor histocompatibility antigen (miHA) disparate BMT mouse models...
  28. Dario C Altieri; Fiscal Year: 2016
    ..We also know that mitochondria-derived survivin forms a complex with a related protein, XIAP, and it is this interaction that cooperatively inhibits apoptosis, and enhances tumor growth, in vivo...
  29. Muxiang Zhou; Fiscal Year: 2016
    ..role of MDM2, we found that the oncoprotein MDM2 can increase the expression of the anti-apoptotic factor XIAP through binding of MDM2's RING domain to the XIAP IRES mRNA, inducing its translational activity...
  30. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..Gas2 inhibits calpain;a protease with substrates that include ?catenin, Stat5 and Xiap. We found a Gas2/calpain-dependent increase in ?catenin in Bcr-abl+ or Icsbp-/- murine bone marrow cells...
  31. Warren D Shlomchik; Fiscal Year: 2016
    ..In MHC-matched alloSCT, GVL-inducing T cells target minor histocompatibility antigens (miHAs). Unfortunately, miHA-reactive T cells also attack nonmalignant host tissues, causing graft-vs-host disease (GVHD)...
  32. Aptosis in an ovine model of intrauterine growth restriction (IUGR)
    Juan A Arroyo; Fiscal Year: 2010
    ..of hyperthermia induced PI-IUGR in the sheep, 2) to elucidate the expression anti-apoptotic molecules BCL-2 and XIAP and the pro-apoptotic molecules BAX, caspase 3 and caspase 9 in the sheep P1-1UGR placentae...
  33. Therapeutics of XIAP Degradation by Zinc Chelators
    Vladimir M Kolenko; Fiscal Year: 2013
    ..ethylenediamine (TPEN) induces selective down-regulation of the X-linked inhibitor of apoptosis protein (XIAP) and sensitizes cancer cells to death ligand-mediated apoptosis...
  34. Apoptosis in an Ovine Model of Intrauterine Growth Restriction (IUGR)
    Juan A Arroyo; Fiscal Year: 2013
    ..of hyperthermia induced PI-IUGR in the sheep, 2) to elucidate the expression anti-apoptotic molecules BCL-2 and XIAP and the pro-apoptotic molecules BAX, caspase 3 and caspase 9 in the sheep PI-IUGR placentae...
  35. Xue Zhong Yu; Fiscal Year: 2014
    ..initiated by T cells that specifically recognize mismatched major (MHC) and/or minor histocompatibility antigens (MiHA)...
  36. Chuanshu Huang; Fiscal Year: 2016
    ..Our preliminary studies found that the X-linked inhibitor of the apoptosis protein (XIAP) was extremely highly expressed in all of the human invasive BC tissues that were tested, but it was barely ..
  37. Song Li; Fiscal Year: 2014
    ..cancer cells to other chemodrugs largely thorough blocking the activity of X-linked inhibitor of apoptosis protein (XIAP). Like many other chemodrugs, embelin is poorly water soluble...
  38. TARGETING REGULATORS OF APOPTOSIS IN AML
    MICHAEL W ANDREEFF; Fiscal Year: 2011
    ..and anti-apoptotic genes in newly diagnosed and relapsed AML and determined critical roles for Bcl-2, Mcl-1 and XIAP. Furthermore, we identified the microenvironment as important for chemosensitivity of AML and identified the ..
  39. ALLOGENEIC MIHA INDUCED MARROW ALLOGRAFT RESISTANCE
    ROBERT BENJAMIN LEVY; Fiscal Year: 2010
    ....
  40. MOLECULAR ANALYSIS OF CHROMOSOME SEGREGATION IN YEAST
    Clarence Chan; Fiscal Year: 1999
    ..All the experiments in this proposal are aimed at understanding the role of the Ilp1 kinase (and to some extent, the PP1 phosphatase) in chromosome segregation fidelity...
  41. Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins
    John Reed; Fiscal Year: 2007
    ..Activity Relations (SAR) studies of analogs will be performed for a prototypical member of the IAP-family, XIAP. Finally, to define the selectivity of the compounds, SAR studies will be performed using assays configured for ..
  42. Robert Korngold; Fiscal Year: 2014
    ..of lethal GVHD and GVT effects by concentrating on how the donor anti-host minor histocompatibility antigen (miHA) T cell repertoire develops and the broad definition of the TCR specificities involved in disease pathogenesis of ..
  43. Sharmila Shankar; Fiscal Year: 2016
    ..maintaining factors (Nanog, Oct-4 and Sox-2), epithelial mesenchymal (EMT) markers (Zeb-1, Snail, Slug), Bcl-2 and XIAP in pancreatic CSCs;(iii) SFN inhibits the expression of Smo, Ptch as well as effector molecule Gli 1 and 2, ..
  44. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..recurrence of leukemia/lymphoma by raising durable cellular immunity against minor histocompatibility antigens (miHA) that are differentially expressed on malignant cells...
  45. Histone Deacetylase Inhibitors in CML
    Kapil Bhalla; Fiscal Year: 2009
    ..Bcr-Abl, as well as by inducing pro-death (Bak, Bax and Bim) and downregulating pro-survival proteins (Bcl-xL, XIAP, AKT and c-Raf), treatment with the HA-HDIs would sensitize IM-sensitive and IM-refractory CML or ALL cells to IM, ..
  46. IMMUNOGENOMICS OF GRAFT VS HOST DISEASE
    Derry Roopenian; Fiscal Year: 2003
    ..host disease (GVHD) because so-called minor histocompatibility antigens (miHA) encoded outside of the MHC act as targets of the GVH response...
  47. John J Lemasters; Fiscal Year: 2016
    ..to cultured hepatocytes underlie hepatic I/R injury in vivo;and 4) the X-linked inhibitor of apoptosis protein (XIAP) decreases during ischemia and sensitizes hepatocytes to the action of death receptor ligands and MPT-dependent ..
  48. RETINAL GENE DELIVERY BY ADENO-ASSOCIATED VIRUS
    William Hauswirth; Fiscal Year: 2009
    ..In addition we will test the efficacy of X-linked Inhibitor of Apoptosis (XIAP) in many of these mouse models by first crossing them into a transgenic line containing constitutively expressed ..
  49. graft-verus-host disease and graft-versus-leukemia
    THEA FRIEDMAN; Fiscal Year: 2007
    ..of lethal GVHD and GVL effects by concentrating on how the donor anti-host minor histocompatibility antigen (miHA) T cell repertoire develops and the broad definition of the TCR specificities involved in disease pathogenesis and ..
  50. Etiology of Pathogenesis of Murine Graft Vs-Host Disease
    Robert Korngold; Fiscal Year: 2009
    ..GVHD in these cases is due to differences in expression of minor histocompatibility antigens (miHA)...
  51. SYNTHETIC INHIBITORS OF CD8+T CELLS IN TRANSPLANTATION
    Robert Korngold; Fiscal Year: 2004
    ..role in most transplantation reactions involving either MHC class I or multiple minor histocompatibility antigen (miHA) disparities...
  52. IDENTIFICATION OF HUMAN MINOR H ANTIGEN PEPTIDES & GENES
    VICTOR ENGELHARD; Fiscal Year: 2003
    Minor histocompatibility antigens (MiHA) have long been known to be key factors in the rejection of solid organ allografts and in the development of graft-versus-host-disease (GVHD) following bone marrow transplantation (BMT) in animal ..
  53. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2004
    ..IKKb on TNF-a-induced apoptosis in T cell subsets, phosphorylation of IkBa, activation of NF-kB, and expression of XIAP, cIAP1 and cIAP2 by Western blotting...
  54. Neuroprotection via XIAP gene therapy in Huntington's disease
    Michael Kaplitt; Fiscal Year: 2007
    ..b>XIAP is a potent inhibitor of apoptosis and thus represents an attractive target for neuroprotection in Huntington'..
  55. LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLS
    Wei Chen; Fiscal Year: 2002
    ..antigens responsible for GVHD and GVL effect are functionally defined as the minor histocompatibility antigens (MiHA)...
  56. CDK/histone deacetylase inhibition in acute leukemia
    Steven Grant; Fiscal Year: 2006
    ..and other kinases, leading to down-regulation/inactivation of various anti-apoptotic proteins, including p21CIP1, XIAP, Mcl-1, NF-kappa B, and diminished phosphorylation of RNA pol II carboxy-terminal domain (CTD)...
  57. Apoptosis in Laminin alpha2-Deficient Muscle Pathology
    JANICE DOMINOV; Fiscal Year: 2009
    ..We will also examine expression of other apoptotic regulatory molecules, specifically FLIPL, ARC, XIAP, and Apaf-1, in normal and laminin a2-deficient muscle cells...
  58. GENE THERAPHY FOR PARKINSON'S DISEASE
    Martha Bohn; Fiscal Year: 2004
    ..Viral vectors harboring genes that block specific apoptotic death pathways, including XIAP, a dominant-negative caspase-9, bcl-2 and bclxl will be studied for effects on survival and function of DA neurons ..
  59. Investigations into XIAP-deficient X-linked Lymphoproliferative Disease
    Rebecca Marsh; Fiscal Year: 2009
    X-Linked Inhibitor of Apoptosis (XIAP) deficiency was reported in 2006 as the second known cause of X-linked Lymphoproliferative Syndrome (XLP) by Rigaud et al...
  60. Molecular Mediators of Interferon induced Apoptosis
    Douglas Leaman; Fiscal Year: 2005
    ..known, or hypothesized to regulate apoptotic processes including TNF-Related Apoptosis Inducing Ligand (TRAIL) and XIAP-associated factor-1 (XAF-1)...
  61. E2F-1 Cancer Gene Therapy
    Kelly McMasters; Fiscal Year: 2005
    ..Furthermore, NFkappaB activation and downregulation of inhibitors of apoptosis (IAPs, specifically XIAP and cIAP-1) and the antiapoptotic Bcl-2 family member, Mcl-1 were seen after E2F-1- overexpression, again novel ..
  62. Neuroprotection and ERK activation by HSV-2 gene ICP10PK
    Laure Aurelian; Fiscal Year: 2007
    ..support or oxidative stress, (ii) To engineer vectors that target both both upstream (ICP10 PK) and downstream (XIAP or p35) apoptotic effectors and examine their anti-apopotic activity (relative to ICP10 RR) in organotypic cultures ..
  63. Diagnosis and prognosis of lung cancer using gene ratios
    GAVIN GORDON; Fiscal Year: 2004
    ..Specific Aim 4. To develop software for the expression ratio test and to design a form summarizing the results of the diagnostic test kit to clinicians and health care personnel. ..