WRAP53

Summary

Gene Symbol: WRAP53
Description: WD repeat containing, antisense to TP53
Alias: DKCB3, TCAB1, WDR79, WD repeat-containing protein 79, WD40 protein Wrap53, WD40 repeat-containing protein encoding RNA antisense to p53, telomerase Cajal body protein 1
Species: human

Top Publications

  1. doi Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Mol Cell 33:462-71. 2009
  2. pmc WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    PLoS Biol 8:e1000521. 2010
  3. ncbi Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Int J Cancer 121:2532-8. 2007
  4. pmc A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Science 323:644-8. 2009
  5. pmc WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients
    Hong Zhang
    Division of Biomedicine, The Systems Biology Research Center, University of Skovde, Skovde, Sweden
    BMC Cancer 12:294. 2012
  6. doi Limbal stem cell deficiency in patients with inherited stem cell disorder of dyskeratosis congenita
    Deniz Aslan
    Section of Hematology, Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey
    Int Ophthalmol 32:615-22. 2012
  7. ncbi Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells
    Jian Min Yuan
    Department of Orthopedics, The First Affiliated Hospital, China
    Asian Pac J Cancer Prev 12:3465-9. 2011
  8. pmc Telomerase recruitment requires both TCAB1 and Cajal bodies independently
    J Lewis Stern
    Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Mol Cell Biol 32:2384-95. 2012
  9. pmc The relationship between DNA methylation and telomere length in dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging Cell 11:24-8. 2012
  10. ncbi Overlapping region of p53/wrap53 transcripts: mutational analysis and sequence similarity with microRNA-4732-5p
    Nasser Pouladi
    Department of Cellular and Molecular Biology, School of Biology, College of Sciences, University of Tehran, Tabriz, Iran
    Asian Pac J Cancer Prev 14:3503-7. 2013

Research Grants

Scientific Experts

  • Inderjeet Dokal
  • Deniz Aslan
  • Qing Lan
  • Montserrat Garcia-Closas
  • Santos Alonso
  • Marianne Farnebo
  • Steven E Artandi
  • Salah Mahmoudi
  • Andrew S Venteicher
  • Sharon A Savage
  • Blanche P Alter
  • Neelam Giri
  • Krzysztof Medrek
  • Nasser Pouladi
  • Sandra Ortiz-Cuaran
  • Caihong Xing
  • J Lewis Stern
  • Shahinaz M Gadalla
  • Beata E Jady
  • Hong Zhang
  • M Bug
  • Franklin Zhong
  • S Mahmoudi
  • Amanda Polson
  • Luis F Z Batista
  • Ricardo Saldaña-Meyer
  • Alison B Singer
  • Jian Min Yuan
  • Emily D Egan
  • Sofia Henriksson
  • Klas G Wiman
  • Kazimierz T Tycowski
  • Jens Laitinen
  • Gaelle Bougeard
  • Pierre Hainaut
  • Bohdan Gorski
  • Zhengyong Zou
  • John D Groopman
  • Min Zheng
  • Mohammadali Hosseinpour Feizi
  • Piotr Magnowski
  • Reyhaneh Ravanbakhsh Gavgani
  • Jan Lubinski
  • Marek Spaczynski
  • Marlin D Friesen
  • Amelie Chabrier
  • Anita Chudecka-Głaz
  • Bogdan Torbé
  • Stephanie Villar
  • David Cox
  • Qi Chen
  • Lifang Hou
  • Linyuan Zhang
  • Jacek Gronwald
  • Xin Liu
  • Thiravud Khuhaprema
  • Shideh Montasser Kouhsari
  • Janusz Menkiszak
  • Geoffroy Durand
  • Simona Ognjanovic
  • Xinbiao Guo
  • Suleeporn Sangrajrang
  • Parvin Azarfam
  • Bartłomiej Masojć
  • Qian Fei Wang
  • Florence Le Calvez-Kelm
  • Guilan Li
  • Fatma M Shebl
  • Hilda A Pickett
  • Tracy M Bryan
  • Katherine G Zyner
  • Hormuzd A Katki
  • Da Wei Wang
  • Scott B Cohen
  • Gunnar Adell
  • Tamas Kiss
  • Amandine Ketele
  • Xiao Feng Sun
  • Marina Shkreli
  • Arthur J Zaug
  • L Farnebo
  • Sharon M Crary
  • Ha Nam Nguyen
  • Guo Qing Hou
  • Renee A Reijo Pera
  • M Dobbelstein
  • Shi Xin Du
  • Renee Chen
  • David Reisman
  • Timothy Myers

Detail Information

Publications32

  1. doi Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Mol Cell 33:462-71. 2009
    ..We have identified a natural antisense transcript of p53, designated Wrap53, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated ..
  2. pmc WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies
    Salah Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    PLoS Biol 8:e1000521. 2010
    The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies...
  3. ncbi Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Int J Cancer 121:2532-8. 2007
    ..We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer...
  4. pmc A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Science 323:644-8. 2009
    ..Here, we identify a holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are important for ..
  5. pmc WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients
    Hong Zhang
    Division of Biomedicine, The Systems Biology Research Center, University of Skovde, Skovde, Sweden
    BMC Cancer 12:294. 2012
    Expression of WRAP53 protein has oncogenic properties and it is up regulated in several types of tumors.
  6. doi Limbal stem cell deficiency in patients with inherited stem cell disorder of dyskeratosis congenita
    Deniz Aslan
    Section of Hematology, Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey
    Int Ophthalmol 32:615-22. 2012
    ..All eight known disease-causing genes in DC (DKC1, TERC, TERT, NOP10, NHP2, TINF2, C16orf57, and TCAB1) were screened for mutations. The family members of the cases were also assessed, when possible...
  7. ncbi Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells
    Jian Min Yuan
    Department of Orthopedics, The First Affiliated Hospital, China
    Asian Pac J Cancer Prev 12:3465-9. 2011
    ..We sought to investigate changes in Wrap53 and p53 levels in an osteosarcoma cell line (U-2OS) exposed to cisplatin and to study apoptosis before and after ..
  8. pmc Telomerase recruitment requires both TCAB1 and Cajal bodies independently
    J Lewis Stern
    Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Mol Cell Biol 32:2384-95. 2012
    ..In human cells, recruitment depends on the Cajal body RNA chaperone TCAB1 binding to the RNA subunit of telomerase (hTR) and is also thought to rely on an N-terminal domain of the ..
  9. pmc The relationship between DNA methylation and telomere length in dyskeratosis congenita
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging Cell 11:24-8. 2012
    ..an increase in % subtelomeric methylation in DC patients with a telomerase-complex mutation (TERC, TERT, DKC1, or TCAB1) (63.0% in DC vs. 61.8% in relatives, P = 0.03)...
  10. ncbi Overlapping region of p53/wrap53 transcripts: mutational analysis and sequence similarity with microRNA-4732-5p
    Nasser Pouladi
    Department of Cellular and Molecular Biology, School of Biology, College of Sciences, University of Tehran, Tabriz, Iran
    Asian Pac J Cancer Prev 14:3503-7. 2013
    ..The wrap53α transcript is one of those that acts as a natural antisense agent, forming RNA-RNA hybrids with p53 mRNA and ..
  11. doi Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma
    Sandra Ortiz-Cuaran
    International Agency for Research on Cancer, Lyon, France
    Genes Chromosomes Cancer 52:912-9. 2013
    ..This domain contains two coding sequences overlapping with TP53 (WRAP53 and Hp53int1) suggesting that sequences in TP53 intron 1 encode transcripts that may modulate R249S mutation rate ..
  12. doi Transcriptional and epigenetic regulation of the p53 tumor suppressor gene
    Ricardo Saldaña-Meyer
    Instituto de Fisiologia Celular, Departamento de Genetica Molecular, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    Epigenetics 6:1068-77. 2011
    ..p53 gene expression is tightly controlled through a variety of transcription factors, miRNAs, its anti-sense RNA Wrap53, the insulator protein CTCF and very likely by other genetic and epigenetic mechanisms...
  13. pmc Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs
    Beata E Jady
    Laboratoire de Biologie Moleculaire Eucaryote du CNRS, UMR5099, IFR109 CNRS, Universite Paul Sabatier, 31062 Toulouse Cedex 9, France
    Genes Dev 26:1897-910. 2012
    ..the 3' hairpin of AluACA RNAs carries two closely spaced CB localization motifs, CAB boxes (UGAG), which bind Wdr79 in a cumulative fashion...
  14. pmc Association of common WRAP 53 variant with ovarian cancer risk in the Polish population
    Krzysztof Medrek
    Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
    Mol Biol Rep 40:2145-7. 2013
    ..b>WRAP53 which overlaps the TP53 is required to maintain normal levels of p53 upon DNA damage, but also when altered may ..
  15. doi Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers
    Caihong Xing
    Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China
    Environ Mol Mutagen 54:397-405. 2013
    ..associated with benzene-induced hematotoxicity (BLM, CYP1A1, EPHX1, ERCC3, NQO1, NUDT1, p15, p16, RAD51, TP53 and WRAP53) in 77 benzene-exposed workers and 25 unexposed controls in China...
  16. ncbi Vectorettes for long chromosome walking in genomic DNA of the human p53 gene
    Jens Laitinen
    University of Helsinki, Helsinki, Finland
    Biotechniques 37:674-6, 678. 2004
    ..We further sequenced the 5' region of the p53 gene and found that the nucleotides upstream of -1009 are transcribed in antisense orientation into a messenger RNA (mRNA) (flj10385) encoding a putative serine/threonine kinase...
  17. doi Dyskeratosis congenita
    Inderjeet Dokal
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Hematology Am Soc Hematol Educ Program 2011:480-6. 2011
    ..15 years have led to significant advances, with 8 DC genes (DKC1, TERC, TERT, NOP10, NHP2, TIN2, C16orf57, and TCAB1) having been characterized...
  18. pmc An inducible nuclear body in the Drosophila germinal vesicle
    Alison B Singer
    Department of Embryology, Carnegie Institution for Science, Baltimore MD, USA
    Nucleus 2:403-9. 2011
    ..Induced bodies are formed in GVs of flies that are null for coilin or WDR79, proteins that are required for formation of Cajal bodies (CBs)...
  19. doi A bidirectional promoter reporter vector for the analysis of the p53/WDR79 dual regulatory element
    Amanda Polson
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, United States
    Plasmid 66:169-79. 2011
    ..Recently, the p53 tumor suppressor gene was shown to have a bidirectional gene partner, WDR79. The transcription start sites (TSSs) of human and murine p53 and WDR79 genes are separated by approximately 800 ..
  20. pmc Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
    Luis F Z Batista
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 474:399-402. 2011
    ..In iPSCs from a form of dyskeratosis congenita caused by mutations in TCAB1 (also known as WRAP53), telomerase catalytic activity is unperturbed, yet the ability of telomerase to lengthen telomeres is abrogated, ..
  21. pmc Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 30:50-8. 2009
    ..Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further ..
  22. pmc A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles
    Kazimierz T Tycowski
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Mol Cell 34:47-57. 2009
    ..Its human homolog, WDR79, associates with C/D, H/ACA, and mixed domain scaRNAs, as well as with telomerase RNA...
  23. ncbi TCAB1: driving telomerase to Cajal bodies
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Cell Cycle 8:1329-31. 2009
    ..A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo...
  24. ncbi Wrap53, a novel regulator of p53
    Marianne Farnebo
    Department of Oncology Pathology, Cancer Centrum Karolinska CCK, Karolinska Institutet, Stockholm SE 17176, Sweden
    Cell Cycle 8:2343-6. 2009
    ..b>Wrap53 is a natural antisense transcript of p53 that regulates endogenous p53 mRNA levels and is furthermore required for ..
  25. doi The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79
    Santos Alonso
    Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Barrio Sarriena s n, ES 48940 Leioa, Bizkaia, Spain
    Hum Hered 69:34-44. 2010
    ..Thus, one might argue that this single central node network lacks robustness. Therefore, we wanted to investigate if natural selection has played a role in shaping the genomic region containing TP53...
  26. pmc Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
    Emily D Egan
    Department of Molecular and Cell Biology, 331 LSA, University of California, Berkeley, CA 94720 3200, USA
    Mol Cell Biol 30:2775-86. 2010
    ..Fourth, we address a difference in predicted specificities of hTR association with the holoenzyme subunit WDR79/TCAB1. Together, these results complete the analysis of hTR elements required for active RNP biogenesis and define the ..
  27. doi The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer
    Marianne Farnebo
    Dept of Oncology Pathology, Cancer Center Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 396:85-9. 2010
    ..A p53 antisense gene, Wrap53, enhances p53 mRNA levels via the 5'UTR...
  28. pmc Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
    Franklin Zhong
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 25:11-6. 2011
    ..We identify DC patients with missense mutations in TCAB1, a telomerase holoenzyme protein that facilitates trafficking of telomerase to Cajal bodies...
  29. pmc WRAP53 promotes cancer cell survival and is a potential target for cancer therapy
    S Mahmoudi
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cell Death Dis 2:e114. 2011
    We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor...
  30. doi Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms
    M Bug
    Department of Molecular Oncology, Göttingen Center of Molecular Biosciences GZMB, Ernst Caspari Haus, University of Gottingen, Gottingen, Germany
    Oncogene 30:3612-24. 2011
    ..Instead, a natural antisense transcript of TP53, WRAP53, was strongly augmented by idarubicin and etoposide, but only less so by the other anthracyclines under study...
  31. ncbi Screening for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene
    Gaelle Bougeard
    INSERM EMI 9906 IFRMP, Faculty of Medicine, Rouen, France
    Oncogene 22:840-6. 2003
    ..We conclude that TP53 germline rearrangements occur as rare events, but must be considered in LFS families without detectable point TP53 mutation...

Research Grants1

  1. Defining the telomerase holoenzyme in progenitor cells with aging
    Steven E Artandi; Fiscal Year: 2010
    ..Through this approach, we identified a new component of the telomerase holoenzyme, termed TCAB1, for Telomerase Cajal Body Protein 1. TCAB1 associates with all active telomerase enzyme and associates with all TERC in human cell ..