Gene Symbol: WNT9B
Description: Wnt family member 9B
Alias: WNT14B, WNT15, protein Wnt-9b, protein Wnt-14b, wingless-type MMTV integration site family member 9B, wingless-type MMTV integration site family, member 15
Species: human
Products:     WNT9B

Top Publications

  1. Goel S, Chin E, Fakhraldeen S, Berry S, Beebe D, Alexander C. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J Biol Chem. 2012;287:16454-66 pubmed publisher
    ..This subgroup of canonical ligands includes Wnt1, Wnt9b, and Wnt10b; the latter two are expressed in mammary gland...
  2. Brito L, Mallikarjunappa S, Sargolzaei M, Koeck A, Chesnais J, Schenkel F, et al. The genetic architecture of milk ELISA scores as an indicator of Johne's disease (paratuberculosis) in dairy cattle. J Dairy Sci. 2018;101:10062-10075 pubmed publisher
    ..regions included 2 single nucleotide polymorphisms located 2 kb upstream of positional candidate genes CD86 and WNT9B, which play key roles in host immune response and tissue homeostasis...
  3. Ramalingam H, Fessler A, Das A, Valerius M, Basta J, Robbins L, et al. Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Dev Biol. 2018;440:13-21 pubmed publisher
    ..More recently it was discovered that one molecule, Wnt9b, was necessary for both renewal and differentiation of the nephron progenitor cells...
  4. Juriloff D, Harris M, Mager D, Gagnier L. Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain. Birth Defects Res A Clin Mol Teratol. 2014;100:772-88 pubmed publisher
    ..Clf1 acts as a mutant allele of Wnt9b but its coding sequence is normal...
  5. Boivin F, Sarin S, Lim J, Javidan A, Svajger B, Khalili H, et al. Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium. PLoS ONE. 2015;10:e0120347 pubmed publisher
    ..b>Wnt9b, the key signal for the induction of nephron progenitors, was markedly reduced in adjacent ureteric epithelial ..
  6. Akpa M, Iglesias D, Chu L, Cybulsky M, Bravi C, Goodyer P. Wilms tumor suppressor, WT1, suppresses epigenetic silencing of the β-catenin gene. J Biol Chem. 2015;290:2279-88 pubmed publisher
    ..As a result, amniotic fluid mesenchymal stem cells acquire responsiveness to WNT9b and increase expression of genes that mark the onset of nephron differentiation...
  7. Yan H, Shen X, Cui X, Wu Y, Wang L, Zhang L, et al. Identification of genes involved in gonadal sex differentiation and the dimorphic expression pattern in Takifugu rubripes gonad at the early stage of sex differentiation. Fish Physiol Biochem. 2018;44:1275-1290 pubmed publisher
    ..of gsdf, dmrt1, dmrt3, cyp11c1, star, and hsd3b expression were higher in XY, while the levels of foxl2, cyp19a1a, wnt9b, and foxD4 expression were higher in XX...
  8. Chiga M, Ohmori T, Ohba T, Katabuchi H, Nishinakamura R. Preformed Wolffian duct regulates Müllerian duct elongation independently of canonical Wnt signaling or Lhx1 expression. Int J Dev Biol. 2014;58:663-8 pubmed publisher
    ..Likewise, a few reports supported this notion in mice, including studies on Wnt9b mutant mice and Wolffian duct-specific Lhx1 deletion...
  9. Yu Y, Zuo X, He M, Gao J, Fu Y, Qin C, et al. Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity. Nat Commun. 2017;8:14364 pubmed publisher
    ..41 SNPs within 26 loci that achieve genome-wide significance, 14 of which are novel (RAD54B, TMEM19, KRT18, WNT9B, GSC/DICER1, PTCH1, RPS26, OFCC1/TFAP2A, TAF1B, FGF10, MSX1, LINC00640, FGFR1 and SPRY1)...

More Information


  1. Hu L, Lü J, Chiang H, Wu H, Edge A, Shi F. Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice. J Neurosci. 2016;36:9479-89 pubmed publisher
    ..A variety of Wnts (Wnt1, Wnt2, Wnt2b, Wnt4, Wnt5a, Wnt7b, Wnt9a, Wnt9b, and Wnt11) and Wnt pathway component Krm2 were upregulated after DT damage...
  2. Waschk D, Tewes A, Romer T, Hucke J, Kapczuk K, Schippert C, et al. Mutations in WNT9B are associated with Mayer-Rokitansky-Küster-Hauser syndrome. Clin Genet. 2016;89:590-6 pubmed publisher
    ..To date, most cases remain unexplained at molecular level. As female Wnt9b-/- mice show a MRKHS-like phenotype, WNT9B has emerged as a promising candidate gene for this disease...
  3. Suzuki A, Abdallah N, Gajera M, Jun G, Jia P, Zhao Z, et al. Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018;150:21-27 pubmed publisher
    ..Human genotype-phenotype analysis revealed that variants in five human homologous CP genes (IRF6, FOXE1, VAX1, WNT9B, and GAD1) significantly contributed to the human CP phenotype...
  4. Song R, Janssen A, Li Y, El Dahr S, Yosypiv I. Prorenin receptor controls renal branching morphogenesis via Wnt/?-catenin signaling. Am J Physiol Renal Physiol. 2017;312:F407-F417 pubmed publisher
    ..Three genes with expression in UB cells that previously shown to regulate UB branching morphogenesis, including Wnt9b, ?-catenin, and Fgfr2, were upregulated, whereas the expression of Wnt11, Bmp7, Etv4
  5. Oppelt P, Müller A, Stephan L, Dittrich R, Lermann J, Büttner C, et al. Hyperandrogenemia and high prolactin in congenital utero-vaginal aplasia patients. Reproduction. 2017;153:555-563 pubmed publisher
    ..The sequencing of WNT4, WNT5A, WNT7A and WNT9B demonstrated no significant mutations correlating with hyperandrogenemia...
  6. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..The failure of Wnt11 signaling reduced the expression of several genes implicated in kidney development, such as Wnt9b, Six2, Foxd1 and Hox10...
  7. Kirikoshi H, Sekihara H, Katoh M. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. Int J Oncol. 2001;19:947-52 pubmed
    b>WNT14B was cloned and characterized in this study. WNT14B encoded 357-amino acid WNT family protein with the signal peptide and an N-linked glycosylation site. WNT14B was most homologous to WNT14 (61.4% total amino acid identity)...
  8. Kirikoshi H, Sekihara H, Katoh M. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. Int J Oncol. 2001;19:1221-5 pubmed
    WNT proteins play key roles in carcinogenesis. We have previously cloned and characterized WNT14 and WNT14B/WNT15...
  9. Goddard L, Duchemin A, Ramalingan H, Wu B, Chen M, Bamezai S, et al. Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Dev Cell. 2017;43:274-289.e5 pubmed publisher
    ..Endocardial Klf2 deficiency results in defective valve formation associated with loss of Wnt9b expression and reduced canonical WNT signaling in neighboring mesenchymal cells, a phenotype reproduced by ..
  10. Pan X, Karner C, Carroll T. Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells. Development. 2017;144:4173-4182 pubmed publisher
    ..We previously showed that in the developing kidney, Wnt9b regulates distinct β-catenin-dependent transcriptional programs in the renewing and differentiating populations ..
  11. Onodera S, Saito A, Hasegawa D, Morita N, Watanabe K, Nomura T, et al. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype. PLoS ONE. 2017;12:e0184702 pubmed publisher
    ..We discovered three genes, PTCH2, BOC, and WNT9b, with mutations with a predicted functional impact assessed by MutationTaster2 or PolyPhen-2 (Polymorphism ..
  12. Dong X, Landford W, Hart J, Risolino M, Kaymakcalan O, Jin J, et al. Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs. Plast Reconstr Surg. 2017;140:75-85 pubmed publisher
    ..at an early gestational stage, the authors designed a minimally invasive surgical approach suitable for intrauterine repair using Wnt9b-soaked collagen microspheres to restore craniofacial developmental programs for cleft correction.
  13. Grainger S, Richter J, Palazón R, Pouget C, Lonquich B, Wirth S, et al. Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Rep. 2016;17:1595-1606 pubmed publisher
    ..Wnt9a is specifically required for this process and cannot be replaced by Wnt9b or Wnt3a...
  14. Ma W, Li Y, Wang M, Li H, Su T, Li Y, et al. Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han. PLoS ONE. 2015;10:e0130202 pubmed publisher
    ..Seventeen candidate loci in the AMH, PBX1, WNT4, WNT7A, WNT9B, HOXA10, HOXA11, LHXA1 and GALT genes were genotyped using the Sequenom MassARRAY iPLEX platform...
  15. Bergstein I, Eisenberg L, Bhalerao J, Jenkins N, Copeland N, Osborne M, et al. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Genomics. 1997;46:450-8 pubmed
    ..We have isolated a number of WNT sequences from human genomic DNA, two of which, designated WNT14 and WNT15, represent novel members of the Wnt gene family...
  16. Lee C, Bendriem R, Kindberg A, Worden L, Williams M, Drgon T, et al. Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation. Cell Rep. 2015;10:616-32 pubmed publisher
    ..two karyotypically normal lines, BG03 and CT3, and BG01V2, with trisomy 17, exhibited amplification of the WNT3/WNT9B region and rapid mDA differentiation...
  17. Qian J, Jiang Z, Li M, Heaphy P, Liu Y, Shackleford G. Mouse Wnt9b transforming activity, tissue-specific expression, and evolution. Genomics. 2003;81:34-46 pubmed
    ..We report an analysis of mouse Wnt9b (also called Wnt15 and Wnt14b), including its cDNA sequence, chromosomal mapping, epithelial cell transforming activity, adult and embryonic ..
  18. Chiquet B, Blanton S, Burt A, Ma D, Stal S, Mulliken J, et al. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum Mol Genet. 2008;17:2212-8 pubmed publisher
    ..Furthermore, the clf1 region in A/WyN clefting susceptible mice contains the Wnt3 and Wnt9B genes...
  19. Reutter H, Draaken M, Pennimpede T, Wittler L, Brockschmidt F, Ebert A, et al. Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder. Hum Mol Genet. 2014;23:5536-44 pubmed publisher
    ..09 × 10(-6)) in a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B. Subsequent analyses in mice revealed expression for both genes in the genital region during stages relevant to ..
  20. Tang R, Dang Y, Qin Y, Zou S, Li G, Wang Y, et al. WNT9B in 542 Chinese women with Müllerian duct abnormalities: mutation analysis. Reprod Biomed Online. 2014;28:503-7 pubmed publisher
    The WNT9B gene is a common organizing signal regulating different segments of the mammalian urogenital system and plays a primary role in the development of the female reproductive tract...
  21. Das A, Tanigawa S, Karner C, Xin M, Lum L, Chen C, et al. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol. 2013;15:1035-44 pubmed publisher
    ..Recent data suggest that Wnt9b, a ureteric-bud-derived factor, is sufficient for both progenitor cell renewal and differentiation...
  22. Baril M, Es Saad S, Chatel Chaix L, Fink K, Pham T, Raymond V, et al. Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathog. 2013;9:e1003416 pubmed publisher
    ..Here we show that secretion of WNT2B and WNT9B and stabilization of ?-catenin (CTNNB1) upon virus infection negatively regulate expression of representative ..
  23. Lyons P, Rayner T, Trivedi S, Holle J, Watts R, Jayne D, et al. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med. 2012;367:214-23 pubmed publisher
    ..These data provide preliminary support for the concept that proteinase 3 ANCA-associated vasculitis and myeloperoxidase ANCA-associated vasculitis are distinct autoimmune syndromes. (Funded by the British Heart Foundation and others.). ..
  24. Ravel C, Lorenço D, Dessolle L, Mandelbaum J, McElreavey K, Darai E, et al. Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome. Fertil Steril. 2009;91:1604-7 pubmed publisher
    ..This supports the hypothesis that mutations in the coding sequence of WNT4, WNT5A, WNT7A, and WNT9B are not responsible for the Mayer-Rokitansky-Kuster-Hauser syndrome.
  25. Fontoura C, Silva R, Granjeiro J, Letra A. Association of WNT9B Gene Polymorphisms With Nonsyndromic Cleft Lip With or Without Cleft Palate in Brazilian Nuclear Families. Cleft Palate Craniofac J. 2015;52:44-8 pubmed publisher
    ..The aim of this study was to evaluate the association between polymorphisms in WNT3 and WNT9B genes and CL/P in Brazilian families...
  26. Wang M, Li Y, Ma W, Li H, He F, Pu D, et al. Analysis of WNT9B mutations in Chinese women with Mayer-Rokitansky-Küster-Hauser syndrome. Reprod Biomed Online. 2014;28:80-5 pubmed publisher
    ..The WNT9B gene encodes a secretory glycoprotein essential for the caudal extension of the Müllerian duct during embryonic ..
  27. Menezes R, Letra A, Kim A, Küchler E, Day A, Tannure P, et al. Studies with Wnt genes and nonsyndromic cleft lip and palate. Birth Defects Res A Clin Mol Teratol. 2010;88:995-1000 pubmed publisher
    ..In addition, two WNT genes, Wnt3 and Wnt9B, are located in the clf1 cleft locus in mice...