Gene Symbol: WNT7A
Description: Wnt family member 7A
Alias: protein Wnt-7a, proto-oncogene Wnt7a protein, wingless-type MMTV integration site family, member 7A
Species: human
Products:     WNT7A

Top Publications

  1. Bui T, Lako M, Lejeune S, Curtis A, Strachan T, Lindsay S, et al. Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. Gene. 1997;189:25-9 pubmed
    The Wnt gene family has a role in development as well as tumourigenesis. One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro...
  2. Parr B, McMahon A. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature. 1998;395:707-10 pubmed
    ..b>Wnt7a-deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are Mü..
  3. Calvo R, West J, Franklin W, Erickson P, Bemis L, Li E, et al. Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A. 2000;97:12776-81 pubmed
    ..During development, the WNT pathway affects cell fate, polarity, and proliferation, and WNT7a has been implicated in the maintenance of HOX expression...
  4. Li S, Chiang T, Davis G, Williams R, Wilson V, McLachlan J. Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. J Clin Endocrinol Metab. 2001;86:454-7 pubmed
    ..To explore the molecular mechanisms underlying the pathogenesis of uterine leiomyoma, the expression of Wnt7a mRNA in the leiomyoma has been assessed. RT-PCR was performed on uterine leiomyomas and the adjacent myometria...
  5. Ohira T, Gemmill R, Ferguson K, Kusy S, Roche J, Brambilla E, et al. WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A. 2003;100:10429-34 pubmed
    ..We previously reported that expression of WNT7a, encoded on 3p25, was frequently downregulated in lung cancer, and that loss of E-cadherin or beta-catenin was a ..
  6. Timmreck L, Pan H, Reindollar R, Gray M. WNT7A mutations in patients with Müllerian duct abnormalities. J Pediatr Adolesc Gynecol. 2003;16:217-21 pubmed
    b>WNT7A gene mutations were evaluated as a potential cause for Müllerian duct derivative abnormalities in human females. The WNT gene family encodes glycoproteins that serve as signaling molecules during early development...
  7. Winn R, Marek L, Han S, Rodriguez K, Rodriguez N, Hammond M, et al. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. J Biol Chem. 2005;280:19625-34 pubmed
  8. Woods C, Stricker S, Seemann P, Stern R, Cox J, Sherridan E, et al. Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. Am J Hum Genet. 2006;79:402-8 pubmed
    ..In families with these syndromes, we found homozygous missense mutations in the dorsoventral-patterning gene WNT7A and confirmed their functional significance in retroviral-mediated transfection of chicken mesenchyme cell ..
  9. Winn R, Van Scoyk M, Hammond M, Rodriguez K, Crossno J, Heasley L, et al. Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2006;281:26943-50 pubmed
    ..These data suggest that ERK5-dependent activation of PPARgamma represents a major effector pathway mediating the anti-tumorigenic effects of Wnt 7a and Fzd 9 in NSCLC. ..

More Information

Publications153 found, 100 shown here

  1. Lindberg D, Akerstrom G, Westin G. Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. Clin Endocrinol (Oxf). 2007;66:110-4 pubmed
    ..We have analysed whether WNT7A or HDAC11 was biallelically inactivated in a group of well-characterized PETs...
  2. Davis E, Zou Y, Ghosh A. Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev. 2008;3:32 pubmed publisher
    ..We used in situ hybridization to show that several Wnt ligands (Wnt3, Wnt5a, Wnt7a, and Wnt7b) and their receptors, Frizzled, are expressed in the developing hippocampus during the period of ..
  3. Ciani L, Boyle K, Dickins E, Sahores M, Anane D, Lopes D, et al. Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²?/Calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A. 2011;108:10732-7 pubmed publisher
    ..Here, we demonstrate that Wnt7a preferentially stimulates excitatory synapse formation and function...
  4. Yoshioka S, King M, Ran S, Okuda H, Maclean J, McAsey M, et al. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Mol Cancer Res. 2012;10:469-82 pubmed publisher
    ..In this study, we found abundant WNT7A in the epithelium of serous ovarian carcinomas, but not detected in borderline and benign tumors, normal ovary, or ..
  5. Oppelt P, Müller A, Stephan L, Dittrich R, Lermann J, Büttner C, et al. Hyperandrogenemia and high prolactin in congenital utero-vaginal aplasia patients. Reproduction. 2017;153:555-563 pubmed publisher
    ..The sequencing of WNT4, WNT5A, WNT7A and WNT9B demonstrated no significant mutations correlating with hyperandrogenemia...
  6. Sun J, Rockowitz S, Xie Q, Ashery Padan R, Zheng D, Cvekl A. Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. Nucleic Acids Res. 2015;43:6827-46 pubmed publisher
    ..In lens, Pax6 directly regulates cell cycle exit via components of FGF (Fgfr2, Prox1 and Ccnd1) and Wnt (Dkk3, Wnt7a, Lrp6, Bcl9l, and Ccnd1) signaling pathways...
  7. Ferguson L, Kaftanovskaya E, Manresa C, Barbara A, Poppiti R, Tan Y, et al. Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract. Biol Reprod. 2016;94:67 pubmed publisher
    ..Similar oviductal phenotypes have been detected previously in mice with activated Smo and in beta-catenin, Wnt4, Wnt7a, and Dicer conditional knockouts, indicating a common regulatory pathway disrupted by these genetic abnormalities.
  8. Haro E, Delgado I, Junco M, Yamada Y, Mansouri A, Oberg K, et al. Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development. PLoS Genet. 2014;10:e1004468 pubmed publisher
    ..to an irregular and immature AER that is not maintained in the center of the bud and on the abnormal expansion of Wnt7a expression to the ventral ectoderm...
  9. Sundqvist A, Morikawa M, Ren J, Vasilaki E, Kawasaki N, Kobayashi M, et al. JUNB governs a feed-forward network of TGF? signaling that aggravates breast cancer invasion. Nucleic Acids Res. 2017;: pubmed publisher
    ..Consistently, overexpression of WNT7A or WNT7B enhanced and potentiated TGF?-induced breast cancer cell invasion, while inhibition of the WNT pathway ..
  10. Sundaram G, Ismail H, Bashir M, Muhuri M, Vaz C, Nama S, et al. EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis. J Exp Med. 2017;214:2889-2900 pubmed publisher
    ..FSTL1 blocks Wnt7a-mediated repression of extracellular signal-regulated kinase phosphorylation, enabling production of MMP9, which ..
  11. Lacour F, Vezin E, Bentzinger C, Sincennes M, Giordani L, Ferry A, et al. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Rep. 2017;18:2320-2330 pubmed publisher
    ..increase in muscle fusion was dependent on downregulation of Wnt/β-catenin and upregulation of non-canonical Wnt7a/Fzd7/Rac1 signaling...
  12. Suo L, Sundberg J, Everts H. Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle. Exp Biol Med (Maywood). 2015;240:618-23 pubmed publisher
    ..marker of canonical wingless-type Mouse Mammary Tumor Virus integration site family (WNT) signaling) and levels of WNT7A within the hair follicle bulge in these C3H/HeJ mice...
  13. Mazemondet O, Hübner R, Frahm J, Koczan D, Bader B, Weiss D, et al. Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation. Cell Mol Biol Lett. 2011;16:515-38 pubmed publisher
    ..pathway are strongly activated and regulated as shown by mRNA up-regulation of Wnt ligands (Wnt5a and Wnt7a), receptors including Frizzled-2, -3, -6, -7, and -9, and co-receptors, and target genes including Axin2...
  14. Maltare A, Nietz A, Laszczyk A, Dunn T, Ballestas M, Accavitti Loper M, et al. Development and characterization of monoclonal antibodies to detect klotho. Monoclon Antib Immunodiagn Immunother. 2014;33:420-7 pubmed publisher
    ..With this confidence in antibody specificity, co-immunoprecipitation was utilized to validate the interaction of Klotho/FGFR and Klotho/wnt7a in mouse kidney lysates.
  15. McCullough K, Choi D, Guo J, Zimmerman K, Walton J, Rainnie D, et al. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala. Nat Commun. 2016;7:13149 pubmed publisher
    ..RNA sequencing identifies genes strongly upregulated in RNA of this population, including Ntsr2, Dkk3, Rspo2 and Wnt7a. Pharmacological manipulation of neurotensin receptor 2 confirms behavioural effects observed in optogenetic and ..
  16. Turner T, Hormozdiari F, Duyzend M, McClymont S, Hook P, Iossifov I, et al. Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA. Am J Hum Genet. 2016;98:58-74 pubmed publisher
    ..In addition, we provide evidence of gene-disruptive CNVs (in DISC1, WNT7A, RBFOX1, and MBD5), as well as smaller de novo CNVs and exon-specific SNVs missed by exome sequencing in ..
  17. Cho I, Park S, Lee S, Nah S, Park H, Yang J, et al. The role of Wnt/β-catenin signaling in the restoration of induced pluripotent stem cell-derived retinal pigment epithelium after laser photocoagulation. Lasers Med Sci. 2019;34:571-581 pubmed publisher
    ..At day 5, after laser photocoagulation, mRNA levels of Wnt2b, Wnt3, Wnt5a, Wnt7a, and Wnt10b were increased...
  18. Ma W, Tian W. [The function of transcription factor P63 and its signaling pathway during limb development]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014;31:466-8 pubmed publisher
    ..signaling pathways are related to the digit formation along three axes, including SHH-ZPA, FGFs-AER and Lmx1B-Wnt7a-En1...
  19. Shen C, Li L, Zhao K, Bai L, Wang A, Shu X, et al. Motoneuron Wnts regulate neuromuscular junction development. elife. 2018;7: pubmed publisher
    ..Intriguingly, these phenotypes were not observed when deleting Wls in muscles or Schwann cells. We identified Wnt7A and Wnt7B as major Wnts for nerve terminal development in rescue experiments...
  20. Griveau A, Seano G, Shelton S, Kupp R, Jahangiri A, Obernier K, et al. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018;33:874-889.e7 pubmed publisher
    ..Experimentally, Olig2 promotes Wnt7b expression, a finding that correlates in human glioma profiling. Targeted Wnt7a/7b deletion or pharmacologic Wnt inhibition blocks Olig2+ glioma single-cell vessel co-option and ..
  21. Zhou Y, Nathans J. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev Cell. 2014;31:248-56 pubmed publisher
    ..and genetic loss- and gain-of-function experiments in mice, we show that Gpr124 functions as a coactivator of Wnt7a- and Wnt7b-stimulated canonical Wnt signaling via a Frizzled receptor and Lrp coreceptor and that Gpr124-..
  22. Cheng S, Shao J, Cai J, Sierra O, Towler D. Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem. 2008;283:20505-22 pubmed publisher
    ..01), along with Wnt7a and Wnt7b, and reduced circulating Dkk1...
  23. Prunskaite Hyyryläinen R, Skovorodkin I, Xu Q, Miinalainen I, Shan J, Vainio S. Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract. Hum Mol Genet. 2016;25:1059-73 pubmed publisher
    ..mouse mammary tumor virus (MMTV) integration site family member (Wnt) genes, including Wnt4, Wnt5a and Wnt7a, are involved in the development of MD and its derivatives, with Wnt4 particularly critical, since the MD fails to ..
  24. McLeod F, Bossio A, Marzo A, Ciani L, Sibilla S, Hannan S, et al. Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors. Cell Rep. 2018;23:1060-1071 pubmed publisher
    ..We found that LTP induction rapidly increased synaptic Wnt7a/b protein levels...
  25. Yuriguchi M, Aoki H, Taguchi N, Kunisada T. Pigmentation of regenerated hairs after wounding. J Dermatol Sci. 2016;84:80-87 pubmed publisher
    ..An increase of Wnt7a of the keratinocytes was observed in the skin at this stage, which may direct melanocyte stem cells to produce ..
  26. Wu D, Jiang Y, He R, Tao L, Yang M, Fu X, et al. High expression of WNT7A predicts poor prognosis and promote tumor metastasis in pancreatic ductal adenocarcinoma. Sci Rep. 2018;8:15792 pubmed publisher
    ..b>WNT7A, an important ligand of Wnt/β-catenin signaling pathways, has a controversial role in tumor development...
  27. Vatansever H, Gumus B, Aydogdu O, Sivrikoz O, Türköz Uluer E, Kivanç M, et al. The role of stem/progenitor cells and Wnt/β-catenin signaling pathway in the patients with prostate cancer. Minerva Urol Nefrol. 2014;66:249-55 pubmed
    ..We also compared the immunoreactivity of Wnt7a, a part of Wnt signaling pathway which has a potential role in the progression of several cancers including ..
  28. de Farias A, Nunes K, Lemes R, Moura R, Fernandes G, Melo U, et al. Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations. Sci Rep. 2018;8:16552 pubmed publisher
    ..to infer the origin of each chromosomal segments containing disorder-causing mutations in KLC2, IMPA1, MED25 and WNT7A. Genotyped data were generated from 18 patients affected by AR diseases and combined to the 1000 genome project (..
  29. Carmon K, Loose D. Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. Biochem Biophys Res Commun. 2008;368:285-91 pubmed publisher
    ..Here, we show, using an ELISA-based protein-protein binding assay that purified Wnt7a binds to the extracellular cysteine-rich domain of Fzd5 in the nanomolar range...
  30. Mazahery A, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis G, et al. Functional analysis of ectodermal ?-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013;53:34-41 pubmed publisher
    ..For this purpose, the conditional loss of function mouse mutant Wnt7a-Cre;?-cat(f/f) was utilized...
  31. Becer E, Hanoğlu D, Kabadayı H, Hanoglu A, Vatansever S, Yavuz D, et al. The effect of Colchicum pusillum in human colon cancer cells via Wnt/β-catenin pathway. Gene. 2019;686:213-219 pubmed publisher
    ..immunocytochemistry using antibodies directed against to β-catenin, Ki-67, LGR-5 Ki-67, DKK1, Frizzled-4, Wnt4, Wnt7a and caspase3 in Colo-741 cells...
  32. Guerrero Schimpf M, Milesi M, Luque E, Varayoud J. Glyphosate-based herbicide enhances the uterine sensitivity to estradiol in rats. J Endocrinol. 2018;: pubmed publisher
    ..of Ki67, iii) the expression of the estrogen receptors alpha (ESR1) and beta (ESR2), and iv) the expression of WNT7A and ?-catenin. GBH-exposed animals showed increased luminal epithelial height and stromal nuclei density...
  33. Zhang Z, Xiang L, Bai D, Wang W, Li Y, Pan J, et al. The protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulating Wnt and p38 MAPK signaling. Nutrients. 2014;6:5853-70 pubmed publisher
    ..several genes had the potential to code for proteins that were involved in the Wnt/β-catenin signaling pathway (Wnt7a, Fzd2, Tcf3, Spp1, Frzb, Sfrp2 and Sfrp4) and the p38 MAPK signaling pathway (Il1rn and Mapk14)...
  34. Wang M, Wang D, Yin Y, Lu L, Shi Y, Huang Y, et al. [Shenshuai Yingyang capsule ameliorates muscle atrophy in rats with chronic renal failure: role of Wnt7a-Akt/mTOR signal pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:1170-4 pubmed
    ..Capsule (SSYYJN) in ameliorating muscle atrophy in rats with chronic renal failure (CRF) and explore the role of Wnt7a-Akt/mTOR signal pathway in mediating this effect...
  35. Mehdinejadiani S, Amidi F, Mehdizadeh M, Barati M, Safdarian L, Aflatoonian R, et al. The effects of letrozole and clomiphene citrate on ligands expression of Wnt3, Wnt7a, and Wnt8b in proliferative endometrium of women with Polycystic ovarian syndrome. Gynecol Endocrinol. 2018;34:775-780 pubmed publisher
    ..citrate (CC) and letrozole, we measured the expression of some main ligands of Wnt/β-catenin signaling including Wnt7a, Wnt3, and Wnt8b in the endometrial samples taken from PCOS women on day 12 of the menses who received 100 mg CC ..
  36. Yan J, Zhou Q, Yu H, Hou M, Lu L. [High glucose promotes vascular smooth muscle cell calcification by activating WNT signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:29-33 pubmed
    ..WNT signaling pathway in human VSMCs by up-regulating the expressions of WNT signal molecules including Wnt3a, Wnt7a, Fzd4 and Wisp1 mRNA by 1.86, 1.68, 2.1, and 2...
  37. Browne M, Carter T, Kay D, Kuehn D, Brody L, Romitti P, et al. Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies. Am J Med Genet A. 2012;158A:2463-72 pubmed publisher
    ..Genotypes were obtained for 132 SNPs in genes involved in limb development (SHH, WNT7A, FGF4, FGF8, FGF10, TBX3, TBX5, SALL4, GREM1, GDF5, CTNNB1, EN1, CYP26A1, CYP26B1), angiogenesis (VEGFA, HIF1A, ..
  38. King M, Lindberg M, Stodden G, Okuda H, Ebers S, Johnson A, et al. WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene. 2015;34:3452-62 pubmed publisher
    We previously characterized the link between WNT7A and the progression of ovarian cancer. Other groups have identified FGF1 as a relevant risk factor in ovarian cancer...
  39. Kerekes K, Bányai L, Patthy L. Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites. FEBS Lett. 2015;589:3044-51 pubmed publisher
    ..Using C-terminal domains of Wnt5a and Wnt7a and arginine-scanning mutagenesis of the WIF domain we demonstrate that, whereas the N-terminal, lipid-modified "..
  40. Wang W, Yan X, Lin Y, Ge H, Tan Q. Wnt7a promotes wound healing by regulation of angiogenesis and inflammation: Issues on diabetes and obesity. J Dermatol Sci. 2018;: pubmed publisher
    ..endothelial cells (HUVEC-C) in response to different levels of glucose and palmitic acid, and explore the role of Wnt7a in wound healing...
  41. Lin J, Sene A, Wiley L, Santeford A, Nudleman E, Nakamura R, et al. WNT7A/B promote choroidal neovascularization. Exp Eye Res. 2018;174:107-112 pubmed publisher
    ..However, it has not yet been established whether WNT7A and/or WNT7B are involved in neovascular AMD pathogenesis...
  42. Zhou S, Eid K, Glowacki J. Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res. 2004;19:463-70 pubmed
    ..RT-PCR, and Western blot, TGF-beta activated genes in the TGF-beta/Smad pathway, upregulated Wnt2, Wnt4, Wnt5a, Wnt7a, Wnt10a, and Wnt co-receptor LRP5, and increased nuclear accumulation and stability of beta-catenin in KM101 cells...
  43. Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, et al. Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS ONE. 2014;9:e104937 pubmed publisher
    ..NTs can increase the expression of Wnt1 and Wnt7a in hMSCs...
  44. Vallon M, Yuki K, Nguyen T, Chang J, Yuan J, Siepe D, et al. A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Cell Rep. 2018;25:339-349.e9 pubmed publisher
    b>WNT7A and WNT7B control CNS angiogenesis and blood-brain barrier formation by activating endothelial Wnt/β-catenin signaling...
  45. Mercer K, Hennings L, Ronis M. Alcohol consumption, Wnt/β-catenin signaling, and hepatocarcinogenesis. Adv Exp Med Biol. 2015;815:185-95 pubmed publisher
    ..05), increased cytosolic expression p-GSK3β (p<0.05), significant upregulation of soluble Wnts, Wnt2, and Wnt7a, and increased expression of several β-catenin targets involved in tumor promotion and progression, cyclin D1, ..
  46. Kim B, Kim I, Yoon S. Identification of miR-199a-5p target genes in the skin keratinocyte and their expression in cutaneous squamous cell carcinoma. J Dermatol Sci. 2015;79:137-47 pubmed publisher
    ..We identified new target genes, Bcam, Fzd6, and Wnt7a, as well as previously known targets, Ddr1 and Podxl...
  47. Gao Y, Jiang J, Yang S, Hou Y, Liu G, Zhang S, et al. CNV discovery for milk composition traits in dairy cattle using whole genome resequencing. BMC Genomics. 2017;18:265 pubmed publisher
    ..These genes included INS, IGF2, FOXO3, TH, SCD5, GALNT18, GALNT16, ART3, SNCA and WNT7A, implying their potential association with milk protein and fat traits...
  48. Frost J, Estivill X, Ramsay M, Tikly M. Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis. Clin Rheumatol. 2019;38:933-938 pubmed publisher
    ..These included the Wnt ligands WNT7A and WNT10A, the frizzled receptors FZD8 and FZD9, intracellular signaling proteins AXIN1 and AXIN2, and the ..
  49. Kwak H, Park D, Seo J, Moon J, Kim T, Sohn J, et al. The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma. Exp Mol Med. 2015;47:e198 pubmed publisher
    ..b>Wnt7a mRNA expression was prominent in induced sputum from patients with asthma compared with that from healthy controls...
  50. Nicaise A, Johnson K, Willis C, Guzzo R, Crocker S. TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling. Mol Neurobiol. 2019;56:3380-3392 pubmed publisher
    ..by TIMP-1 to promote OPC differentiation was counteracted, but not abrogated, by canonical signaling evoked by Wnt7a. These data provide a previously uncharacterized trophic action of TIMP-1 to regulate oligodendrocyte maturation ..
  51. Lyu J, Joo C. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J Biol Chem. 2005;280:21653-60 pubmed
    ..By regulating the proliferation of corneal epithelial cells, Wnt-7a and MMP-12 appear to contribute to corneal wound healing. ..
  52. Winuthayanon W, Hewitt S, Korach K. Uterine epithelial cell estrogen receptor alpha-dependent and -independent genomic profiles that underlie estrogen responses in mice. Biol Reprod. 2014;91:110 pubmed publisher
    ..A uterine epithelial ERalpha conditional knockout mouse model (Wnt7a(Cre+);Esr1(f/f) or cKO) demonstrated that ERalpha in the epithelial cells was dispensable for an initial uterine ..
  53. Ramos Solano M, Meza Canales I, Torres Reyes L, Alvarez Zavala M, Alvarado Ruíz L, Rincon Orozco B, et al. Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration. Exp Cell Res. 2015;335:39-50 pubmed publisher
    ..non-tumorigenic, but immortalized human keratinocytes. Interestingly, WNT7A expression was found strongly downregulated in cell lines and biopsies derived from CC...
  54. Liu S, Yang H, Hu B, Zhang M. Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/?-catenin signaling pathways. Exp Ther Med. 2017;14:5057-5062 pubmed publisher
    ..associated X protein (Bax), procaspase-3 and -9, matrix metalloproteinase 1 (MMP1), MMP3, MMP13, Wnt3a, Wnt5a, Wnt7a and ?-catenin were significantly inhibited (P<0...
  55. Simitsidellis I, Gibson D, Cousins F, Esnal Zufiaurre A, Saunders P. A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus. Endocrinology. 2016;157:2116-28 pubmed publisher
    ..in the regulation of the cell cycle (Wee1, Ccnd1, Rb1) and stromal-epithelial interactions (Wnt4, Wnt5a, Wnt7a, Cdh1, Vcl, Igf1, Prl8, Prlr) as well as a striking effect on the number of endometrial glands...
  56. Chandra V, Fatima I, Manohar M, Popli P, Sirohi V, Hussain M, et al. Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/β-catenin signaling and PI3K/Akt survival pathway. Cell Death Dis. 2014;5:e1380 pubmed publisher
    ..compound K-1 reduced the viability of primary endometrial hyperplasial cells and expression of ERα, PR, PCNA, Wnt7a, FZD6, pGsk3β and β-catenin without affecting the growth of the primary culture of normal endometrial cells...
  57. Borowicz S, Van Scoyk M, Avasarala S, Karuppusamy Rathinam M, Tauler J, Bikkavilli R, et al. The soft agar colony formation assay. J Vis Exp. 2014;:e51998 pubmed publisher
    ..cell line, CMT167, to demonstrate the tumor suppressive effects of two members of the Wnt signaling pathway, Wnt7A and Frizzled-9 (Fzd-9)...
  58. Vanhollebeke B, Stone O, Bostaille N, Cho C, Zhou Y, Maquet E, et al. Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. elife. 2015;4: pubmed publisher
    ..We identify the GPI-anchored MMP inhibitor Reck and the adhesion GPCR Gpr124 as integral components of a Wnt7a/Wnt7b-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis...
  59. Baranowska Körberg I, Hofmeister W, Markljung E, Cao J, Nilsson D, Ludwig M, et al. WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish. Hum Mol Genet. 2015;24:5069-78 pubmed publisher
    ..In total 13 variants were identified in WNT3, WNT6, WNT7A, WNT8B, WNT10A, WNT11, WNT16, FZD5, LRP1 and LRP10 genes and predicted as potentially disease causing, of which ..
  60. Guerrero Schimpf M, Milesi M, Ingaramo P, Luque E, Varayoud J. Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus. Toxicology. 2017;376:2-14 pubmed publisher
    ..we evaluated the expression of estrogen receptor alpha (ER?), progesterone receptor (PR), Hoxa10 and Wnt7a by IHC...
  61. Freis A, Keller A, Ludwig N, Meese E, Jauckus J, Rehnitz J, et al. Altered miRNA-profile dependent on ART outcome in early pregnancy targets Wnt-pathway. Reproduction. 2017;154:799-805 pubmed publisher
    ..The 11 miRNAs showing the highest significant alterations were all associated with the regulation of WNT3 and WNT7a. While WNT7a presented with a significant decrease between ET and PT in case of ongoing pregnancy, women with ..
  62. Guero S. Developmental biology of the upper limb. Hand Surg Rehabil. 2018;37:265-274 pubmed publisher
    ..For the dorsoventral differentiation, the signaling center is the dorsal ectoderm, which secretes WNT7A. Limb segmentation is described in three parts (arm, forearm and hand) along with the formation of the digital ..
  63. Li S, Herrera G, Tam K, Lizarraga J, Beedle M, Winuthayanon W. Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity. Sci Rep. 2018;8:11247 pubmed publisher
    ..action in the vagina, we used a mouse model in which Esr1 was conditionally ablated from the epithelial cells (Wnt7acre/+; Esr1f/f)...
  64. Vigezzi L, Ramos J, Kass L, Tschopp M, Muñoz de Toro M, Luque E, et al. A deregulated expression of estrogen-target genes is associated with an altered response to estradiol in aged rats perinatally exposed to bisphenol A. Mol Cell Endocrinol. 2016;426:33-42 pubmed publisher
    ..b>Wnt7a expression was lower in GSM of BPA50 rats than in controls...
  65. Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A, Melchiorri D, et al. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J Biol Chem. 2003;278:37024-31 pubmed
    ..b>WNT7A is a WNT family member expressed in the vertebrate central nervous system capable of modulating aspects of ..
  66. von Maltzahn J, Renaud J, Parise G, Rudnicki M. Wnt7a treatment ameliorates muscular dystrophy. Proc Natl Acad Sci U S A. 2012;109:20614-9 pubmed publisher
    ..b>Wnt7a signaling through its receptor Fzd7 accelerates and augments regeneration by stimulating satellite stem cell ..
  67. Chen J, Hoffman J, Arora R, Perrone L, Gonzalez Gomez C, Vo K, et al. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016;105:501-10.e1 pubmed publisher
    ..05) expression of epithelial-specific genes AREG, CDH1, DEFB4A, MMP7, and WNT7A, while exhibiting low-to-undetectable (P<.05) stromal-specific genes COL6A3, HOXA11, MMP2, PDGFRB, and WNT5A...
  68. Dong L, Hao H, Liu J, Ti D, Tong C, Hou Q, et al. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice. Stem Cells Int. 2017;2017:3738071 pubmed publisher
    ..The mechanisms of action of MSCs and Wnt proteins on skin wounds are largely unknown. Here, we prepared a Wnt7a-containing conditioned medium (Wnt-CM) from the supernatant of cultured human umbilical cord-MSCs (UC-MSCs) ..
  69. Tribulo P, Jumatayeva G, Lehloenya K, Moss J, Negrón Pérez V, Hansen P. Effects of sex on response of the bovine preimplantation embryo to insulin-like growth factor 1, activin A, and WNT7A. BMC Dev Biol. 2018;18:16 pubmed publisher
    ..embryos to develop to the blastocyst stage, insulin-like growth factor 1 (IGF1), activin A, and WNT member 7A (WNT7A), were evaluated for actions on embryos produced in vitro with X- or Y- sorted semen from the same bull...
  70. Rieger M, Sims A, Coats E, Clarke R, Briegel K. The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Mol Cell Biol. 2010;30:4267-79 pubmed publisher
    ..In contrast, LBH induction by Wnt/beta-catenin signaling is inhibited by Wnt7a, which in limb development signals through a noncanonical pathway involving Lmx1b...
  71. Hu T, Ping L, Hsu S, Tsai H, Cheng M. Mutation analysis of the WNT7A gene in patients with schizophrenia. Psychiatry Res. 2018;265:246-248 pubmed publisher
    Aberrant WNT signaling has been implicated in the pathophysiology of schizophrenia. WNT7A, a member of the WNT gene family, is considered a potential candidate of schizophrenia...
  72. Fukunaga Kalabis M, Hristova D, Wang J, Li L, Heppt M, Wei Z, et al. UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch. J Invest Dermatol. 2015;135:1521-1532 pubmed publisher
    ..differentiation was triggered by the endogenous Notch inhibitor Numb, which is upregulated in the stem cells by Wnt7a derived from UV-irradiated keratinocytes...
  73. Ma A, Xie S, ZHOU J, Zhu Y. Nomegestrol Acetate Suppresses Human Endometrial Cancer RL95-2 Cells Proliferation In Vitro and In Vivo Possibly Related to Upregulating Expression of SUFU and Wnt7a. Int J Mol Sci. 2017;18: pubmed publisher
    ..NOMAC altered the expression of several genes related to cancer cell proliferation, including SUFU and Wnt7a...
  74. Al Naib A, Tucker H, Xie G, Keisler D, Bartol F, Rhoads R, et al. Prepubertal tamoxifen treatment affects development of heifer reproductive tissues and related signaling pathways. J Dairy Sci. 2016;99:5780-5792 pubmed publisher
    ..and ? (ESR2) mRNA, ESR1 protein, IGFI, progesterone receptor, total growth hormone receptor, WNT4, WNT5A, and WNT7A mRNA, in addition to mitogen-activated protein kinase (MAPK) and phosphorylated MAPK proteins were affected ..
  75. Tennis M, Van Scoyk M, Freeman S, Vandervest K, Nemenoff R, Winn R. Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Mol Cancer Res. 2010;8:833-43 pubmed publisher
    ..We showed that the activity of the Spry4 promoter is increased by Wnt7A/Fzd9 signaling through peroxisome proliferator-activated receptor gamma...
  76. Yu W, Chen X, Niu W, Wang F, Sun B, Sun Y. Role of Wnt5a in the differentiation of human embryonic stem cells into endometrium-like cells. Int J Clin Exp Pathol. 2015;8:5478-84 pubmed
    ..by our center were differentiated into endometrium-like cells in 4 different media including Wnt5a (Group A), Wnt7a (Group B), secreted frizzled related protein (sFRP, an inhibitor of Wnt signal pathway, Group C) and medium alone (..
  77. Choussein S, Nasioudis D, Schizas D, Economopoulos K. Mullerian dysgenesis: a critical review of the literature. Arch Gynecol Obstet. 2017;295:1369-1381 pubmed publisher
    ..Null-association results of HOXA genes and Wnt5a, Wnt7a, and Wnt9a have been reported, while point mutations of the WNT4 gene point mutations have been associated with an ..
  78. Gaetje R, Holtrich U, Karn T, Cikrit E, Engels K, Rody A, et al. Characterization of WNT7A expression in human endometrium and endometriotic lesions. Fertil Steril. 2007;88:1534-40 pubmed
    To characterize the expression of WNT7A in human eutopic and ectopic endometrium. Experimental study using real-time polymerase chain reaction, laser microdissection, in situ hybridization, and immunofluorescence...
  79. Bikkavilli R, Avasarala S, Van Scoyk M, Arcaroli J, Brzezinski C, Zhang W, et al. Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene. 2015;34:5317-28 pubmed publisher
    ..Here we identify Wnt7a as a novel upstream inducer of cellular senescence...
  80. Tuli R, Tuli S, Nandi S, Huang X, Manner P, Hozack W, et al. Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J Biol Chem. 2003;278:41227-36 pubmed
  81. Ma W, Li Y, Wang M, Li H, Su T, Li Y, et al. Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han. PLoS ONE. 2015;10:e0130202 pubmed publisher
    ..Seventeen candidate loci in the AMH, PBX1, WNT4, WNT7A, WNT9B, HOXA10, HOXA11, LHXA1 and GALT genes were genotyped using the Sequenom MassARRAY iPLEX platform...
  82. Long K, Moss L, Laursen L, Boulter L, ffrench Constant C. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun. 2016;7:10354 pubmed publisher
    ..Transcriptome analysis reveals upregulation of Wnt7a within the CA*β1 cells and upregulation of the ECM protein Decorin in the neighbouring non-expressing cells...
  83. Ingaramo P, Milesi M, Schimpf M, Ramos J, Vigezzi L, Muñoz de Toro M, et al. Endosulfan affects uterine development and functional differentiation by disrupting Wnt7a and β-catenin expression in rats. Mol Cell Endocrinol. 2016;425:37-47 pubmed publisher
    Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a and β-catenin during uterine development leading to the failure of uterine functional differentiation during implantation...
  84. Wilson M, McCoski S, Geiger A, Akers R, Johnson S, Ealy A. The influence of postnatal nutrition on reproductive tract and endometrial gland development in dairy calves. J Dairy Sci. 2017;100:3243-3256 pubmed publisher
    ..Increases in transcript abundance for IGF1 and IGFBP3 and a decrease in abundance of WNT7A were detected in calves fed the enhanced diet at 8 wk of age...
  85. Gibson A, Hui Mingalone C, Foote A, Uchimura T, Zhang M, Zeng L. Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis. Sci Rep. 2017;7:41823 pubmed publisher
    b>Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known...
  86. Delgado I, Torres M. Coordination of limb development by crosstalk among axial patterning pathways. Dev Biol. 2017;429:382-386 pubmed publisher
    ..The dorsal and ventral ectoderms produce, respectively, WNT7A and BMPs, which induce dorso-ventral limb fates...
  87. Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, et al. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol. 2014;205:97-111 pubmed publisher
    b>Wnt7a/Fzd7 signaling stimulates skeletal muscle growth and repair by inducing the symmetric expansion of satellite stem cells through the planar cell polarity pathway and by activating the Akt/mTOR growth pathway in muscle fibers...
  88. Fan X, Krieg S, Hwang J, Dhal S, Kuo C, Lasley B, et al. Dynamic regulation of Wnt7a expression in the primate endometrium: implications for postmenstrual regeneration and secretory transformation. Endocrinology. 2012;153:1063-9 pubmed publisher
    ..Here, we examine the pattern, hormone dependence, and potential functions of Wnt7a (wingless-type MMTV integration site family member 7a), which is known to play a critical role in the formation of ..
  89. Fortes M, Pinheiro C, Guimarães Ferreira L, Vitzel K, Vasconcelos D, Curi R. Overload-induced skeletal muscle hypertrophy is not impaired in STZ-diabetic rats. Physiol Rep. 2015;3: pubmed publisher
    ..In the soleus muscle caused similar changes in both groups: increase in FAK and MGF and decrease in Wnt7a, MuRF-1, atrogin-1, and myostatin...
  90. Nawaz I, Hu L, Du Z, Moumad K, Ignatyev I, Pavlova T, et al. Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma. Oncotarget. 2015;6:31493-507 pubmed publisher
    ..Among ten candidate TSGs identified in chromosome 3 using NotI microarray, ITGA9 and WNT7A could be validated...
  91. Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, et al. Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nat Commun. 2016;7:10305 pubmed publisher
    ..Using in vivo models we identify Wnt7a as a key factor secreted exclusively by aggressive breast tumour cells, which induces CAF conversion...
  92. Yan P, Xu J, Zeng Y, Dong G, Cao H, Zheng M, et al. Long-term effects of repeated superovulation on the uterus and mammary gland in rhesus monkeys. J Assist Reprod Genet. 2017;34:535-545 pubmed publisher
    ..Expression of Wnt7a (associated with the functional/developmental status of the uterus) was significantly decreased in the uterus of ..