WNT10A

Summary

Gene Symbol: WNT10A
Description: Wnt family member 10A
Alias: OODD, SSPS, STHAG4, protein Wnt-10a, wingless-type MMTV integration site family, member 10A
Species: human
Products:     WNT10A

Top Publications

  1. Kirikoshi H, Sekihara H, Katoh M. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. Biochem Biophys Res Commun. 2001;283:798-805 pubmed
    Human WNT10A and WNT6 were cloned and characterized. WNT10A encoded a 417-amino-acid polypeptide with WNT core domain, and WNT6 encoded a 365-amino-acid polypeptide with N-terminal signal peptide, WNT core domain, and RGD motif...
  2. Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, et al. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am J Hum Genet. 2007;81:821-8 pubmed
    ..697G-->T (p.Glu233X) homozygous nonsense mutation in exon 3 of the WNT10A gene in all patients...
  3. Nawaz S, Klar J, Wajid M, Aslam M, Tariq M, Schuster J, et al. WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome. Eur J Hum Genet. 2009;17:1600-5 pubmed publisher
    ..b>WNT10A is expressed in the skin and epidermis and it has shown to be critical for the development of ectodermal ..
  4. Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, et al. WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. Am J Hum Genet. 2009;85:97-105 pubmed publisher
    ..palmoplantar hyperkeratosis, and hyperhidrosis, was recently shown to be caused by a homozygous nonsense WNT10A mutation in three consanguineous Lebanese families...
  5. Yasuniwa Y, Izumi H, Wang K, Shimajiri S, Sasaguri Y, Kawai K, et al. Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway. PLoS ONE. 2010;5:e15330 pubmed publisher
    ..DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and ..
  6. van den Boogaard M, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, et al. Mutations in WNT10A are present in more than half of isolated hypodontia cases. J Med Genet. 2012;49:327-31 pubmed publisher
    ..Recent insights into the role of Wnt10A in tooth development, and the finding of hypodontia in carriers of the autosomal recessive disorder, ..
  7. Gelebart P, Anand M, Armanious H, Peters A, Dien Bard J, Amin H, et al. Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood. 2008;112:5171-9 pubmed publisher
    ..To conclude, WCP is constitutively activated in a subset of MCL and it appears to promote tumorigenesis in MCL. ..
  8. Cluzeau C, Hadj Rabia S, Jambou M, Mansour S, Guigue P, Masmoudi S, et al. Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. Hum Mutat. 2011;32:70-2 pubmed publisher
    ..Recently, WNT10A gene was identified as responsible for various autosomal recessive forms of ectodermal dysplasias, including ..
  9. Grejtakova D, Gabrikova Dojcakova D, Boronova I, Kyjovska L, Hubcejova J, Fecenkova M, et al. WNT10A variants in relation to nonsyndromic hypodontia in eastern Slovak population. J Genet. 2018;97:1169-1177 pubmed
    ..The aim of this study was to search for the variants in wingless-type MMTV-integration site family member (WNT10A), paired box 9 (PAX9) and axis inhibitor 2 (AXIN2) genes, and investigate their potential role ..

More Information

Publications104 found, 100 shown here

  1. Koskinen S, Keski Filppula R, Alapulli H, Nieminen P, Anttonen V. Familial oligodontia and regional odontodysplasia associated with a PAX9 initiation codon mutation. Clin Oral Investig. 2019;: pubmed publisher
    ..Mutations in several genes including MSX1, PAX9, AXIN2, and WNT10A have been shown to cause non-syndromic tooth agenesis...
  2. Ruiz Heiland G, Lenz S, Bock N, Ruf S. Prevalence of WNT10A gene mutations in non-syndromic oligodontia. Clin Oral Investig. 2018;: pubmed publisher
    ..Recently, multiple observations have linked up to 50% of cases with isolated hypodontia to mutations in the WNT10A gene...
  3. Petridis C, Navarini A, Dand N, Saklatvala J, Baudry D, Duckworth M, et al. Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. Nat Commun. 2018;9:5075 pubmed publisher
    ..Likely causal variants disrupt the coding region of WNT10A and a P63 transcription factor binding site in SEMA4B...
  4. Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett C, et al. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017;8:15397 pubmed publisher
    Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of a broad range of ectodermal defects...
  5. Liu J, Zhao C, Zhang J, Han X, Ge S, Du L, et al. [Distribution of WNT10A gene rs10177996 polymorphism between Han and Uygur populations in Xinjiang area]. Shanghai Kou Qiang Yi Xue. 2018;27:164-169 pubmed
    To explore the characteristics of distribution of WNT10A gene rs10177996 polymorphism between Han and Uygur populations in Xinjiang area...
  6. Tsukamoto M, Wang K, Tasaki T, Murata Y, Okada Y, Yamanaka Y, et al. Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle. Bone. 2019;120:75-84 pubmed publisher
    b>Wnt10a is a member of the WNT family. Although deficiency of this gene causes symptoms related to teeth, hair, nails, and skin, we recently demonstrated a new phenotype of Wnt10a knockout (KO) mice involving bone and fat...
  7. Chen X, Shi C, Cao H, Chen L, Hou J, Xiang Z, et al. The hedgehog and Wnt/?-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death Dis. 2018;9:639 pubmed publisher
    ..In our work, we demonstrated the critical role of Gli1, Wnt7b, Wnt10a and Fzd10 in the process of pulmonary fibrogenesis in vitro and in vivo...
  8. Choi D, Han J, Shin J, Ryu C, Yu H, Kim A, et al. Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion. Sci Rep. 2018;8:9782 pubmed publisher
    ..WNT2B, WNT5A, WNT10A, and WNT11 functions in the urothelium were evaluated by silencing in an HBlEpC cell line...
  9. Guo B, Chatterjee S, Li L, Kim J, Lee J, Yechoor V, et al. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012;26:3453-63 pubmed publisher
    ..Promoters of these genes (Wnt10a, ?-catenin, Dishevelled2, TCF3) displayed Bmal1 occupancy, indicating direct circadian regulation by Bmal1...
  10. Nam K, Yi S, Lee J, Lee M, Park J, Oh H, et al. Eudesmin impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Biochem Biophys Res Commun. 2018;505:1148-1153 pubmed publisher
    ..of H2B at serine 36 (H2BS36p) was reduced upon eudesmin treatment, further inducing the expression of Wnt6, Wnt10a, and Wnt10b, which disturbed adipogenic differentiation...
  11. Ueda T, Tsubamoto H, Inoue K, Sakata K, Shibahara H, Sonoda T. Itraconazole Modulates Hedgehog, WNT/?-catenin, as well as Akt Signalling, and Inhibits Proliferation of Cervical Cancer Cells. Anticancer Res. 2017;37:3521-3526 pubmed
    ..The microarray analysis showed an 8-fold down-regulation in the expression of GLI1, WNT4 and WNT10A among itraconazole-treated CaSki cells...
  12. Frost J, Estivill X, Ramsay M, Tikly M. Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis. Clin Rheumatol. 2019;38:933-938 pubmed publisher
    ..These included the Wnt ligands WNT7A and WNT10A, the frizzled receptors FZD8 and FZD9, intracellular signaling proteins AXIN1 and AXIN2, and the pathway target ..
  13. Bociąga Jasik M, Polus A, Góralska J, Czech U, Gruca A, Śliwa A, et al. Metabolic effects of the HIV protease inhibitor--saquinavir in differentiating human preadipocytes. Pharmacol Rep. 2013;65:937-50 pubmed
    ..involved in endoplasmic reticulum (ER) stress, and differentiation (lipid droplet formation) process such as: WNT10a, C/EBPa, AFT4, CIDEC, ADIPOQ, LPIN1...
  14. Chakrabarti R, Celià Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018;360: pubmed publisher
    ..activates Notch signaling in stromal macrophages, increasing their expression of Wnt family ligands such as Wnt3, Wnt10A, and Wnt16, thereby initiating a feedback loop that promotes the function of Dll1-expressing MaSCs...
  15. Liu J, Wang Z, Tang J, Tang R, Shan X, Zhang W, et al. Hepatitis C virus core protein activates Wnt/?-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line. Arch Virol. 2011;156:1013-23 pubmed publisher
    ..that core protein upregulates gene expression of canonical Wnt ligands, such as Wnt2, Wnt3, Wnt3a, Wnt8b, Wnt10a, Wnt10b, frizzled receptors Fzd1, 2, 5, 6, 7, 9, and LRP5/6 co-receptors...
  16. Bae C, Kim T, Ko S, Lee J, Yang X, Cho E. Wntless regulates dentin apposition and root elongation in the mandibular molar. J Dent Res. 2015;94:439-45 pubmed publisher
    ..In immunohistochemistry, Wnt10a, β-catenin, type I collagen, and dentin sialoprotein were significantly down-regulated in the odontoblasts of ..
  17. Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S. Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor. Cancer Res. 2018;78:3698-3708 pubmed publisher
    ..ALDH-positive cells was dependent on the time-dependent release of Wingless-type mmtv integration site family 10a (WNT10a) from ALDH-negative cells...
  18. Sagomonyants K, Mina M. Biphasic effects of FGF2 on odontoblast differentiation involve changes in the BMP and Wnt signaling pathways. Connect Tissue Res. 2014;55 Suppl 1:53-6 pubmed publisher
    ..of growth were associated with increased expression of the components of the BMP (Bmp2, Dlx5, Msx2, Osx) and Wnt (Wnt10a, Wisp2) pathways, and decreased expression of an inhibitor of the Wnt signaling, Nkd2...
  19. Carre A, Hu M, James A, Kawai K, Galvez M, Longaker M, et al. β-Catenin-Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding. Plast Reconstr Surg. 2018;141:669-678 pubmed publisher
    ..Numerous individual Wnt ligands increased in expression after wounding, including Wnt3a, Wnt4, Wnt10a, and Wnt11. A specific pattern of Wnt activity was observed, localized to the hair follicle and epidermis...
  20. Linke F, Zaunig S, Nietert M, von Bonin F, Lutz S, Dullin C, et al. WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene. 2017;36:13-23 pubmed publisher
    ..While application of recombinant WNT5A or WNT5A overexpression stimulates HL cell migration, neither WNT10A, WNT10B nor WNT16 did so. Time-lapse studies revealed an amoeboid type of cell migration modulated by WNT5A...
  21. Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009;9:215-23 pubmed publisher
    ..Our study reveals new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb...
  22. Tatematsu T, Kimura M, Nakashima M, Machida J, Yamaguchi S, Shibata A, et al. An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family. PLoS ONE. 2015;10:e0128227 pubmed publisher
    Congenital tooth agenesis is caused by mutations in the MSX1, PAX9, WNT10A, or AXIN2 genes...
  23. Du R, Dinçkan N, Song X, Coban Akdemir Z, Jhangiani S, Guven Y, et al. Identification of likely pathogenic and known variants in TSPEAR, LAMB3, BCOR, and WNT10A in four Turkish families with tooth agenesis. Hum Genet. 2018;137:689-703 pubmed publisher
    ..a variant in LAMB3 associated with syndromic TA in one family; and a variant in BCOR plus a disease-associated WNT10A variant in one family with syndromic TA...
  24. Sarkar T, Bansal R, Das P. Whole genome sequencing reveals novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis. PLoS ONE. 2014;9:e106811 pubmed publisher
    ..However, candidature of only 5 genes viz. PAX9, MSX1, AXIN2, WNT10A and EDA have been experimentally established for congenitally missing teeth like hypodontia and oligodontia...
  25. Yang J, Wang S, Choi M, Reid B, Hu Y, Lee Y, et al. Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds. Mol Genet Genomic Med. 2015;3:40-58 pubmed publisher
    b>WNT10A is a signaling molecule involved in tooth development, and WNT10A defects are associated with tooth agenesis...
  26. Baranowska Körberg I, Hofmeister W, Markljung E, Cao J, Nilsson D, Ludwig M, et al. WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish. Hum Mol Genet. 2015;24:5069-78 pubmed publisher
    ..In total 13 variants were identified in WNT3, WNT6, WNT7A, WNT8B, WNT10A, WNT11, WNT16, FZD5, LRP1 and LRP10 genes and predicted as potentially disease causing, of which seven variants ..
  27. Islam M, Stemig M, Takahashi Y, Hui S. Radiation response of mesenchymal stem cells derived from bone marrow and human pluripotent stem cells. J Radiat Res. 2015;56:269-77 pubmed publisher
    ..More than 70% downregulation was found in Wnt3A, Wnt4, Wnt 7A, Wnt10A and Wnt11 in BMMSCs, but not in hESMSCs. hESMSCs are highly proliferative but radiosensitive compared with BMMSCs...
  28. Pośpiech E, Karłowska Pik J, Marcińska M, Abidi S, Andersen J, Berge M, et al. Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans. Forensic Sci Int Genet. 2015;19:280-288 pubmed publisher
    ..gene (TCHH) to be significantly associated with hair morphology in Europeans and reported weaker associations for WNT10A and FRAS1 genes...
  29. Liang J, Qin C, Yue H, He H, Bian Z. A novel initiation codon mutation of PAX9 in a family with oligodontia. Arch Oral Biol. 2016;61:144-8 pubmed publisher
    ..studies have attributed non-syndromic tooth agenesis to mutations in several genes, including MSX1, PAX9, AXIN2, WNT10A and EDA. In this study, mutation of PAX9gene was investigated in a four-generation Chinese family with oligodontia...
  30. Hlousková A, Bonczek O, Izakovicová Hollá L, Lochman J, Soukalová J, Stembírek J, et al. Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population. Neuro Endocrinol Lett. 2015;36:452-7 pubmed
    ..Among genes involved in tooth morphogenesis, mutations in PAX9, MSX1, AXIN2, WNT10a, and EDA genes have been associated with tooth agenesis...
  31. Gaczkowska A, Abdalla E, Dowidar K, Elhady G, Jagodzinski P, Mostowska A. De novo EDA mutations: Variable expression in two Egyptian families. Arch Oral Biol. 2016;68:21-8 pubmed publisher
    ..Direct sequencing of the coding regions including exon-intron boundaries of EDA, MSX1, PAX9, WNT10A and EDAR was performed in probands and their available family members...
  32. Yue H, Liang J, Yang K, Hua B, Bian Z. Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. Eur J Oral Sci. 2016;124:228-33 pubmed publisher
    ..inhibition protein 2 (AXIN2), ectodysplasin A (EDA), and wingless-type MMTV integration site family member 10A (WNT10A). In this study, we investigated a Chinese family with non-syndromic tooth agenesis. A novel missense mutation (c...
  33. Zeng B, Xiao X, Li S, Lu H, Lu J, Zhu L, et al. Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients. Genes (Basel). 2016;7: pubmed publisher
    ..EDAR), and EDAR-associated death domain (EDARADD) are candidate genes for HED, but the relationship between WNT10A and HED has not yet been validated...
  34. Martin E, Huang W, Anwar T, Arellano Garcia C, Burman B, Guan J, et al. MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Oncogene. 2017;36:2275-2285 pubmed publisher
    ..mouse and human are important regulators of epithelial morphogenesis including Cdh1, Ck19, Cldn3 and 4, Ddr1, and Wnt10a. These results document a causal role for Ccn6 deletion in the pathogenesis of metaplastic carcinomas with ..
  35. Wang K, Yamada S, Izumi H, Tsukamoto M, Nakashima T, Tasaki T, et al. Critical in vivo roles of WNT10A in wound healing by regulating collagen expression/synthesis in WNT10A-deficient mice. PLoS ONE. 2018;13:e0195156 pubmed publisher
    We have reported that WNT10A plays a critical role in the growth of fibroblasts/myofibroblasts and microvascular endothelial cells, i.e.; wound healing/scarring...
  36. Shen W, Wang Y, Liu Y, Liu H, Zhao H, Zhang G, et al. Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. PLoS ONE. 2016;11:e0154884 pubmed publisher
    ..EDA1 mutant proteins upregulate BMP4 (bone morphogenetic protein 4) mRNA expression and downregulate WNT10A and WNT10B (wingless-type MMTV integration site family member 10A and 10B) mRNA expression...
  37. Chen Y, Wu R, Yang X, Kou S, MacDougald O, Yu L, et al. Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a. Sci Rep. 2016;6:25283 pubmed publisher
    ..This dual effect of 5-Aza-dC was associated with up-regulation of Wnt10a, a key factor determining the fate of the mesenchymal lineage towards osteoblasts...
  38. Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, et al. Mitochondrial function controls intestinal epithelial stemness and proliferation. Nat Commun. 2016;7:13171 pubmed publisher
    ..HSP60-deficient crypts display loss of stemness and cell proliferation, accompanied by epithelial release of WNT10A and RSPO1...
  39. Whitson J, Zhang X, Medvedovic M, Chen J, Wei Z, Monnier V, et al. Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis. Invest Ophthalmol Vis Sci. 2017;58:2666-2684 pubmed publisher
    ..Genes in canonical EMT pathways, including Wnt10a, showed upregulation in lens epithelia samples...
  40. Jing H, Su X, Gao B, Shuai Y, Chen J, Deng Z, et al. Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis. Cell Death Dis. 2018;9:176 pubmed publisher
    ..Accordingly, histone acetylation levels on Wnt genes (Wnt1, Wnt6, Wnt10a, and Wnt10b) were declined in BMSCs from OVX mice...
  41. Jing H, Liao L, An Y, Su X, Liu S, Shuai Y, et al. Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis. Mol Ther. 2016;24:217-229 pubmed publisher
    ..EZH2 directly increased H3K27me3 levels on promoters of Wnt1, Wnt6, and Wnt10a to silence Wnt gene transcription...
  42. Kantaputra P, Kaewgahya M, Hatsadaloi A, Vogel P, Kawasaki K, Ohazama A, et al. GREMLIN 2 Mutations and Dental Anomalies. J Dent Res. 2015;94:1646-52 pubmed publisher
    ..It has been associated with mutations in MSX1, PAX9, EDA, AXIN2, EDAR, EDARADD, and WNT10A. GREMLIN 2 (GREM2) is a strong bone morphogenetic protein (BMP) antagonist that is known to regulate BMPs in ..
  43. Ruiz Heiland G, Jabir S, Wende W, Blecher S, Bock N, Ruf S. Novel missense mutation in the EDA gene in a family affected by oligodontia. J Orofac Orthop. 2016;77:31-8 pubmed publisher
    Mutations in the EDA-EDAR-EDARADD genes and more recently, mutations in the WNT10A gene have been described as the cause of syndromic and nonsyndromic tooth agenesis concomitant with diverse abnormalities of ectodermally derived tissues...
  44. Krøigård A, Clemmensen O, Gjørup H, Hertz J, Bygum A. Odonto-onycho-dermal dysplasia in a patient homozygous for a WNT10A nonsense mutation and mild manifestations of ectodermal dysplasia in carriers of the mutation. BMC Dermatol. 2016;16:3 pubmed publisher
    ..The ectodermal dysplasias resulting from biallelic mutations in the WNT10A gene result in highly variable phenotypes, ranging from isolated tooth agenesis to OODD and Schöpf-Schulz-..
  45. Morman R, Schweickert P, Konieczny S, Taparowsky E. BATF regulates the expression of Nfil3, Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice. Eur J Immunol. 2018;48:1492-1505 pubmed publisher
    ..We examine two genes (Nfil3 and miR155gh) that are positively regulated, and one gene (Wnt10a) that is negatively regulated by BATF during CSR...
  46. Cheung C, Bendris N, Paul C, Hamieh A, Anouar Y, Hahne M, et al. Cyclin A2 modulates EMT via β-catenin and phospholipase C pathways. Carcinogenesis. 2015;36:914-24 pubmed publisher
    ..Components of the canonical wingless (WNT) pathway, including WNT8b, WNT10a, WNT10b, frizzled 1 and 2 and TCF4 were upregulated at the messenger RNA and protein levels following Cyclin A2 ..
  47. Massink M, Créton M, Spanevello F, Fennis W, Cune M, Savelberg S, et al. Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia. Am J Hum Genet. 2015;97:621-6 pubmed publisher
    ..In this same pathway, WNT10A was recently identified as a major contributor in the etiology of non-syndromic oligodontia...
  48. Oda K, Yatera K, Izumi H, Ishimoto H, Yamada S, Nakao H, et al. Profibrotic role of WNT10A via TGF-? signaling in idiopathic pulmonary fibrosis. Respir Res. 2016;17:39 pubmed publisher
    ..signaling plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the role of WNT10A via transforming growth factor (TGF)-? signaling remains unclear...
  49. Haddaji Mastouri M, De Coster P, Zaghabani A, Trabelsi S, May Y, Saad A, et al. Characterization of a novel mutation in PAX9 gene in a family with non-syndromic dental agenesis. Arch Oral Biol. 2016;71:110-116 pubmed publisher
    ..In order to screen for the eventual genetic cause of dental agenesis in this family we sequenced 4 genes; PAX9, WNT10A, MSX1 and AXIN2 using Sanger sequencing. Direct Screening analysis of PAX9 gene, revealed a novel mutation p...
  50. Castori M, Castiglia D, Brancati F, Foglio M, Heath S, Floriddia G, et al. Two families confirm Schöpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum. Clin Genet. 2011;79:92-5 pubmed publisher
  51. Feng C, Duan W, Zhang D, Zhang E, Xu Z, Lu L. C392T polymorphism of the Wnt10a gene in non-syndromic oral cleft in a northeastern Chinese population. Br J Oral Maxillofac Surg. 2014;52:751-5 pubmed publisher
    ..Recent studies have shown that the Wnt10a gene may also contribute...
  52. Cosín Roger J, Ortiz Masiá D, Calatayud S, Hernández C, Esplugues J, Barrachina M. The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD. Mucosal Immunol. 2016;9:986-98 pubmed publisher
    ..These mice also exhibited decreased mucosal expression of Wnt2b, Wnt7b, and Wnt10a, diminished protein levels of nuclear β-catenin that is mainly located in crypts adjacent to damage, and ..
  53. Matsukawa T, Morita K, Omizu S, Kato S, Koriyama Y. Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration. Neurochem Int. 2018;112:71-80 pubmed publisher
    ..After optic nerve injury, mRNA levels of Wnt5b, TAX1BP3 and ICAT increased in the retina, while those of Wnt10a decreased. These changes were associated with a reduction in ?-catenin in nuclei...
  54. Plaisancié J, Bailleul Forestier I, Gaston V, Vaysse F, Lacombe D, Holder Espinasse M, et al. Mutations in WNT10A are frequently involved in oligodontia associated with minor signs of ectodermal dysplasia. Am J Med Genet A. 2013;161A:671-8 pubmed publisher
    ..dominant and autosomal recessive forms are occasionally seen, and result from mutations in at least three genes (WNT10A, EDAR, or more rarely EDARADD)...
  55. Kantaputra P, Kaewgahya M, Kantaputra W. WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity. Am J Med Genet A. 2014;164A:360-3 pubmed publisher
    ..Three heterozygous missense mutations (p.Arg171Cys; p.Gly213Ser; and IVS2+1G>A) were identified in WNT10A in six patients. The p.Gly213Cys mutation was found in four patients. One of the patients who had p...
  56. He H, Han D, Feng H, Qu H, Song S, Bai B, et al. Involvement of and interaction between WNT10A and EDA mutations in tooth agenesis cases in the Chinese population. PLoS ONE. 2013;8:e80393 pubmed publisher
    Dental agenesis is the most common, often heritable, developmental anomaly in humans. Although WNT10A gene mutations are known to cause rare syndromes associated with tooth agenesis, including onycho-odontodermal dysplasia (OODD), Schöpf-..
  57. Wedgeworth E, Nagy N, White J, Pembroke A, McGrath J. Intra-familial variability of ectodermal defects associated with WNT10A mutations. Acta Derm Venereol. 2011;91:346-7 pubmed publisher
  58. Galbraith R, Poole E, Duggan D, Muehling J, Hsu L, MAKAR K, et al. Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk. Nutr Cancer. 2011;63:558-64 pubmed publisher
    ..cases and 516 polyp-free controls, we analyzed two tagSNPs in WNT6 (rs6747776 G > C, rs6754599 G > C) and WNT10A (rs7349332 G > A, rs10177996 A > G)...
  59. Alves Ferreira M, Pinho T, Sousa A, Sequeiros J, Lemos C, Alonso I. Identification of genetic risk factors for maxillary lateral incisor agenesis. J Dent Res. 2014;93:452-8 pubmed publisher
    ..We selected 8 genes-MSX1, PAX9, AXIN2, EDA, SPRY2, TGFA, SPRY4, and WNT10A-and performed one of the largest case-control studies taking into account the number of genes and variants ..
  60. Mues G, Bonds J, Xiang L, Vieira A, Seymen F, Klein O, et al. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014;164A:2455-60 pubmed publisher
    Mutations in the WNT10A gene were first detected in the rare syndrome odonto-onycho-dermal dysplasia (OODD, OMIM257980) but have now also been found to cause about 35-50% of selective tooth agenesis (STHAG4, OMIM150400), a common disorder ..
  61. Zhang Z, Guo Q, Tian H, Lv P, Zhou C, Gao X. Effects of WNT10A on proliferation and differentiation of human dental pulp cells. J Endod. 2014;40:1593-9 pubmed publisher
    Wingless-type MMTV integration site family, member 10A (WNT10A) plays crucial roles in odontogenesis...
  62. Hamilton P, Sun Y, Henry J. Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling. Exp Eye Res. 2016;145:206-215 pubmed publisher
    ..a, wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of ..
  63. Guazzarotti L, Tadini G, Mancini G, Sani I, Pisanelli S, Galderisi F, et al. WNT10A gene is the second molecular candidate in a cohort of young Italian subjects with ectodermal derivative impairment (EDI). Clin Genet. 2017;: pubmed publisher
    ..the impact of the Wnt/beta-catenin pathway in the genetic screening of EDI, we performed a molecular gene study of WNT10A in 60 subjects from a population of 133 young Italian patients referred for the impairment of at least one major ..
  64. Memarian A, Hojjat Farsangi M, Asgarian Omran H, Younesi V, Jeddi Tehrani M, Sharifian R, et al. Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia. Leuk Lymphoma. 2009;50:2061-70 pubmed publisher
    ..Our results indicate up-regulation of many members of the WNT gene family in CLL suggesting involvement of the Wnt canonical and/or noncanonical signaling pathways in CLL tumorigenesis. ..
  65. Heilmann S, Kiefer A, Fricker N, Drichel D, Hillmer A, Herold C, et al. Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology. J Invest Dermatol. 2013;133:1489-96 pubmed publisher
    ..55 × 10(-15)) on chr2q35, which is located intronically in WNT10A. Expression studies in human hair follicle tissue suggest that WNT10A has a functional role in AGA etiology...
  66. Abdalla E, Mostowska A, Jagodziński P, Dwidar K, Ismail S. A novel WNT10A mutation causes non-syndromic hypodontia in an Egyptian family. Arch Oral Biol. 2014;59:722-8 pubmed publisher
    ..The entire coding regions including exon-intron boundaries of the MSX1, PAX9 and WNT10A genes were investigated by direct sequencing in all affected family members...
  67. Long A, Giroux V, Whelan K, Hamilton K, Tetreault M, Tanaka K, et al. WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis. 2015;36:598-606 pubmed publisher
    ..b>WNT10A was found to be >4-fold upregulated in the invasive front...
  68. Dhamo B, Fennis W, Créton M, Vucić S, Cune M, Ploos van Amstel H, et al. The association between WNT10A variants and dental development in patients with isolated oligodontia. Eur J Hum Genet. 2016;25:59-65 pubmed publisher
    In this study we aimed to determine the effect of WNT10A variants on dental development in patients with oligodontia. Forty-three (25 boys and 18 girls) individuals were eligible for this study...
  69. Kuma A, Yamada S, Wang K, Kitamura N, Yamaguchi T, Iwai Y, et al. Role of WNT10A-expressing kidney fibroblasts in acute interstitial nephritis. PLoS ONE. 2014;9:e103240 pubmed publisher
    WNT signaling mediates various physiological and pathological processes. We previously showed that WNT10A is a novel angio/stromagenic factor involved in such processes as tumor growth, wound healing and tissue fibrosis...
  70. Mostowska A, Biedziak B, Zadurska M, Matuszewska Trojan S, Jagodziński P. WNT10A coding variants and maxillary lateral incisor agenesis with associated dental anomalies. Eur J Oral Sci. 2015;123:1-8 pubmed publisher
    ..to determine the contribution of nucleotide variants in wingless-type MMTV integration site family, member 10A (WNT10A), msh homeobox 1 (MSX1), and paired box 9 (PAX9) to the risk of MLIA in a Polish population...
  71. Cuellar Partida G, Springelkamp H, Lucas S, Yazar S, Hewitt A, Iglesias A, et al. WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness. Hum Mol Genet. 2015;24:5060-8 pubmed publisher
    ..We identified a genome-wide significant exonic variant rs121908120 (P = 6.63 × 10(-10)) in WNT10A. This gene is 437 kb from a gene previously associated with CCT (USP37)...
  72. Zeng B, Zhao Q, Li S, Lu H, Lu J, Ma L, et al. Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis. Genes (Basel). 2017;8: pubmed publisher
    ..We screened for mutations of WNT10A, EDA, EDAR, EDARADD, PAX9, MSX1, AXIN2, LRP6, and WNT10B through Sanger sequencing...
  73. Liu F, Chen Y, Zhu G, Hysi P, Wu S, Adhikari K, et al. Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair. Hum Mol Genet. 2017;: pubmed publisher
    ..2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21...
  74. Zhou S, Eid K, Glowacki J. Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res. 2004;19:463-70 pubmed
    ..and Western blot, TGF-beta activated genes in the TGF-beta/Smad pathway, upregulated Wnt2, Wnt4, Wnt5a, Wnt7a, Wnt10a, and Wnt co-receptor LRP5, and increased nuclear accumulation and stability of beta-catenin in KM101 cells...
  75. Mostowska A, Biedziak B, Zadurska M, Dunin Wilczynska I, Lianeri M, Jagodzinski P. Nucleotide variants of genes encoding components of the Wnt signalling pathway and the risk of non-syndromic tooth agenesis. Clin Genet. 2013;84:429-40 pubmed publisher
    ..In addition, direct sequencing was performed to detect mutations in the MSX1, PAX9 and WNT10A genes...
  76. Kimura R, Watanabe C, Kawaguchi A, Kim Y, Park S, Maki K, et al. Common polymorphisms in WNT10A affect tooth morphology as well as hair shape. Hum Mol Genet. 2015;24:2673-80 pubmed publisher
    ..Previous association studies have confirmed that single-nucleotide polymorphisms (SNPs) in/near THADA, FRAS1, WNT10A, NAF1 and FGFR2 are associated with hair morphology...
  77. Kantaputra P, Kapoor S, Verma P, Kaewgahya M, Kawasaki K, Ohazama A, et al. Al-Awadi-Raas-Rothschild syndrome with dental anomalies and a novel WNT7A mutation. Eur J Med Genet. 2017;60:695-700 pubmed publisher
    ..sequencing of the patient and his parents ruled out mutations in 11 known hypodontia-associated genes including WNT10A, MSX1, EDA, EDAR, EDARADD, PAX9, AXIN2, GREM2, NEMO, KRT17, and TFAP2B...
  78. Yuan Q, Zhao M, Tandon B, Maili L, Liu X, Zhang A, et al. Role of WNT10A in failure of tooth development in humans and zebrafish. Mol Genet Genomic Med. 2017;5:730-741 pubmed publisher
    ..We identified a novel compound heterozygous missense mutation in WNT10A (c.637G>A:p.Gly213Ser and c.1070C>T:p...
  79. Beaty T, Hetmanski J, Fallin M, Park J, Sull J, McIntosh I, et al. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. Hum Genet. 2006;120:501-18 pubmed
    ..Additional genes (VAX2, GLI2, ZHFX1B on 2p; WNT6-WNT10A and COL4A3-COL4A4 on 2q) showed consistent evidence of linkage and disequilibrium only among CL/P trios in all ..
  80. Medland S, Nyholt D, Painter J, McEvoy B, McRae A, Zhu G, et al. Common variants in the trichohyalin gene are associated with straight hair in Europeans. Am J Hum Genet. 2009;85:750-5 pubmed publisher
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations. ..
  81. van Geel M, Gattas M, Kesler Y, Tong P, Yan H, Tran K, et al. Phenotypic variability associated with WNT10A nonsense mutations. Br J Dermatol. 2010;162:1403-6 pubmed publisher
  82. Issa Y, Kamal L, Rayyan A, Dweik D, Pierce S, Lee M, et al. Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families. Eur J Hum Genet. 2016;24:1430-5 pubmed publisher
    ..The Wnt signaling pathway is critical to development of ectodermal structures. Mutations in WNT10A, LRP6, EDA, and other genes in this pathway lead to tooth agenesis with or without other ectodermal anomalies...
  83. Yu F, Fan X, Chen B, Dong P, Zheng J. Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a. Cell Physiol Biochem. 2016;39:2409-2420 pubmed
    ..Luciferase reporter assays demonstrated that Wnt10a, a member of Wnt/β-catenin pathway, was confirmed to be a target of miR-378a-3p...
  84. Chen H, Wang Y, Xue F. Expression and the clinical significance of Wnt10a and Wnt10b in endometrial cancer are associated with the Wnt/?-catenin pathway. Oncol Rep. 2013;29:507-14 pubmed publisher
    ..the Wnt/?-catenin signaling pathway in the development of endometrial cancer (EC), we examined the expression of Wnt10a and Wnt10b in EC tissues and the correlation between their expression...
  85. Kantaputra P, Kaewgahya M, Jotikasthira D, Kantaputra W. Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations. Am J Med Genet A. 2014;164A:1041-8 pubmed publisher
    ..1066G>T, and c.1039G>T, and one previously reported (c.637G>A) WNT10A mutations in three patients affected with odonto-onycho-dermal dysplasia (OODD; OMIM 275980)...
  86. Arzoo P, Klar J, Bergendal B, Norderyd J, Dahl N. WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations. Am J Med Genet A. 2014;164A:353-9 pubmed publisher
    A large proportion (>50%) of patients with isolated oligodontia were recently reported with WNT10A mutations. We have analyzed a population-based cohort of 102 individuals diagnosed with non-syndromic oligodontia and a mean of 8...
  87. Song S, Zhao R, He H, Zhang J, Feng H, Lin L. WNT10A variants are associated with non-syndromic tooth agenesis in the general population. Hum Genet. 2014;133:117-24 pubmed publisher
    ..Very few patients suffer severe tooth agenesis. Recent studies revealed that WNT10A gene mutations caused syndromic and isolated severe tooth agenesis...
  88. Hsu R, Ho J, Cha T, Yu D, Wu C, Huang W, et al. WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/?-catenin pathway. PLoS ONE. 2012;7:e47649 pubmed publisher
    ..We screened 19 WNT ligands from normal kidney and RCC cell lines and tissues and found that WNT10A was significantly increased in RCC cell lines and tissues as compared to that in normal controls...
  89. Miyashita S, Ahmed N, Murakami M, Iohara K, Yamamoto T, Horibe H, et al. Mechanical forces induce odontoblastic differentiation of mesenchymal stem cells on three-dimensional biomimetic scaffolds. J Tissue Eng Regen Med. 2017;11:434-446 pubmed publisher
    ..upregulation of bone morphogenetic protein 7 (BMP7) and wingless-type MMTV integration site family member 10a (Wnt10a) was observed...
  90. Yu D, Shang Y, Yuan J, Ding S, Luo S, Hao L. Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase. Cell Physiol Biochem. 2016;39:2001-2013 pubmed
    ..cells into different groups in which cells were treated with different substances: negative control (NC) group, wnt10a siRNA group, β-catenin siRNA group and TERT siRNA group...
  91. Bergendal B, Norderyd J, Zhou X, Klar J, Dahl N. Abnormal primary and permanent dentitions with ectodermal symptoms predict WNT10A deficiency. BMC Med Genet. 2016;17:88 pubmed
    The WNT10A protein is critical for the development of ectodermal appendages. Variants in the WNT10A gene may be associated with a spectrum of ectodermal abnormalities including extensive tooth agenesis...