WNT1

Summary

Gene Symbol: WNT1
Description: Wnt family member 1
Alias: BMND16, INT1, OI15, proto-oncogene Wnt-1, proto-oncogene Int-1 homolog, wingless-type MMTV integration site family member 1, wingless-type MMTV integration site family, member 1 (oncogene INT1)
Species: human
Products:     WNT1

Top Publications

  1. Mizushima T, Nakagawa H, Kamberov Y, Wilder E, Klein P, Rustgi A. Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res. 2002;62:277-82 pubmed
    ..A comparison of extracellular stimuli suggests that specific Wnt family members stabilize beta-catenin with resulting activation of TCF-dependent transcription in ESCC. ..
  2. Longo K, Kennell J, Ochocinska M, Ross S, Wright W, MacDougald O. Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem. 2002;277:38239-44 pubmed
    ..Thus, we demonstrated that Wnt-1 induces expression of antiapoptotic genes in 3T3-L1 preadipocytes such as IGF-I and IGF-II, which allows these cells to resist apoptosis in response to serum deprivation. ..
  3. Fukutomi T, Zhou Y, Kawai S, Eguchi H, Wands J, Li J. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology. 2005;41:1096-105 pubmed publisher
    ..In conclusion, HCV core protein induces Huh-7 cell proliferation whether alone or in the context of HCV replication, which is at least partly mediated by transcriptional upregulation of growth-related genes, in particular wnt-1...
  4. Lin Y, You L, Xu Z, He B, Mikami I, Thung E, et al. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun. 2006;341:635-40 pubmed
    ..Our results indicate that aberrant Wnt signaling is a common event in NPC carcinogenesis linked with WIF-1 silencing in at least cell lines. Strategies targeting these molecules should be potentially promising in treating NPC. ..
  5. Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, et al. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A. 2006;103:3799-804 pubmed
  6. De Ferrari G, Moon R. The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene. 2006;25:7545-53 pubmed
    ..We suggest that the onset/development of such pathological conditions may involve the additive effect of genetic variation within Wnt signaling components and of molecules that modulate the activity of this signaling cascade. ..
  7. Chong Z, Li F, Maiese K. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal. 2007;19:1150-62 pubmed
    Initially described as a modulator of embryogenesis for a number of organ systems, Wnt1 has recently been linked to the development of several neurodegenerative disorders, none being of greater significance than Alzheimer's disease...
  8. Wieczorek M, Paczkowska A, Guzenda P, Majorek M, Bednarek A, Lamparska Przybysz M. Silencing of Wnt-1 by siRNA induces apoptosis of MCF-7 human breast cancer cells. Cancer Biol Ther. 2008;7:268-74 pubmed
    ..Our results significantly indicate that anti-Wnt-1 siRNA inhibits Wnt-1 signaling, inducing apoptosis in human breast cancer MCF-7 cells and thus may serve as a potential anti-cancer drug. ..
  9. Scheller E, Chang J, Wang C. Wnt/beta-catenin inhibits dental pulp stem cell differentiation. J Dent Res. 2008;87:126-30 pubmed
    ..In conclusion, our results suggest that canonical Wnt signaling negatively regulates the odontoblast-like differentiation of DPSCs. ..

More Information

Publications116 found, 100 shown here

  1. Huang C, Liu D, Ishikawa S, Nakashima T, Nakashima N, Yokomise H, et al. Wnt1 overexpression promotes tumour progression in non-small cell lung cancer. Eur J Cancer. 2008;44:2680-8 pubmed publisher
    The Wnt gene family is involved in embryogenesis and tumourigenesis. We investigated the clinical significance of Wnt1 expression in non-small cell lung cancer (NSCLC). We studied 216 NSCLC patients...
  2. Badiglian Filho L, Oshima C, De Oliveira Lima F, De Oliveira Costa H, De Sousa Damião R, Gomes T, et al. Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. Oncol Rep. 2009;21:313-20 pubmed
    ..in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and beta-catenin...
  3. Liu G, Vijayakumar S, Grumolato L, Arroyave R, Qiao H, Akiri G, et al. Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J Cell Biol. 2009;185:67-75 pubmed publisher
    ..However, hMSCs with exogenous expression of Wnt1 but not stabilized beta-catenin markedly stimulate bone formation by naive hMSCs, arguing for an important role of ..
  4. Pizzatti L, Binato R, Cofre J, Gomes B, Dobbin J, Haussmann M, et al. SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer. 2010;49:107-18 pubmed publisher
    ..Finally, we suggest that SUZ12 is blocking cellular differentiation, as SUZ12 knockdown release differentiation programs in chronic myeloid blastic phase (CML-BP) transformed cell line. ..
  5. Xu X, Sun P, Li J, Jheon S, Lee C, Chung J. Aberrant Wnt1/?-catenin expression is an independent poor prognostic marker of non-small cell lung cancer after surgery. J Thorac Oncol. 2011;6:716-24 pubmed publisher
    ..microarray with 262 resected NSCLC specimens was performed to study the expression and subcellular localization of Wnt1 in relation to downstream molecules, including GSK-3?, ?-catenin, c-Myc, cyclin D1, and p53...
  6. Stanczak A, Stec R, Bodnar L, Olszewski W, Cichowicz M, Kozlowski W, et al. Prognostic significance of Wnt-1, ?-catenin and E-cadherin expression in advanced colorectal carcinoma. Pathol Oncol Res. 2011;17:955-63 pubmed publisher
    ..These findings support the hypothesis that Wnt/?-catenin pathway plays an important role in advanced colorectal carcinoma. ..
  7. Wexler E, Rosen E, Lu D, Osborn G, Martin E, Raybould H, et al. Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways. Sci Signal. 2011;4:ra65 pubmed publisher
    ..To gain a systems-level, genome-wide view of Wnt signaling, we analyzed Wnt1-stimulated changes in gene expression by transcriptional microarray analysis in cultured human neural progenitor (..
  8. Wang J, Huang F, Kuo M, Wang Z, Tseng T, Chang L, et al. Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers. J Biol Chem. 2014;289:14612-23 pubmed publisher
    b>WNT1 encodes a multifunctional signaling glycoprotein that is highly expressed in several malignant tumors. Patients with Wnt1-positive cancer are usually related to advanced metastasis...
  9. Lottrup G, Belling K, Leffers H, Nielsen J, Dalgaard M, Juul A, et al. Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents. Mol Hum Reprod. 2017;23:339-354 pubmed publisher
    ..to be expressed in LCs during early development, including sulfotransferase family 2A member 1 (SULT2A1), WNT1-inducible signalling pathway protein 2 (WISP2), hydroxyprostaglandin dehydrogenase (HPGD) and insulin-like growth ..
  10. Zhu X, Zhang Z, Han G, Han J, Qiu D. Overexpression of miR?214 promotes the progression of human osteosarcoma by regulating the Wnt/??catenin signaling pathway. Mol Med Rep. 2017;15:1884-1892 pubmed publisher
    ..Of note, infection with the miR?214 lentivirus did not affect the levels of Wnt1, Wnt2, Wnt4, Axin or glycogen synthase kinase ? in the U2OS cells, whereas the expression levels of ??catenin in ..
  11. Maiese K. Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Curr Neurovasc Res. 2015;12:173-88 pubmed
    ..Multiple treatment approaches are being entertained for DM with Wnt1 inducible signaling pathway protein 1 (WISP1), mechanistic target of rapamycin (mTOR), and silent mating type ..
  12. Marini J, Reich A, Smith S. Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation. Curr Opin Pediatr. 2014;26:500-7 pubmed publisher
    ..and chaperoning, while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specifically induced substance (OASIS) ..
  13. Zhou L, Mo H, Miao J, Zhou D, Tan R, Hou F, et al. Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System. Am J Pathol. 2015;185:3211-23 pubmed publisher
    ..In cultured kidney tubular epithelial cells, Klotho dose-dependently blocked Wnt1-triggered RAS activation...
  14. Chang Y, Hsu S, Yang C, Sung P, Chen Y, Huang T, et al. Enhanced protection against renal ischemia-reperfusion injury with combined melatonin and exendin-4 in a rodent model. Exp Biol Med (Maywood). 2016;241:1588-602 pubmed publisher
    ..target of rapamycin) biomarkers, as well the podocyte dysfunction biomarkers (Wnt1/Wnt4/?-catenin) displayed a pattern identical to that of creatinine level among the five groups (all p?<?0.001)...
  15. Seberg H, Van Otterloo E, Loftus S, Liu H, Bonde G, Sompallae R, et al. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017;13:e1006636 pubmed publisher
    ..Paralogs Tfap2a and Tfap2b are both expressed in mouse melanocytes, and we show that mouse embryos with Wnt1-Cre-mediated deletion of Tfap2a and Tfap2b in the neural crest almost completely lack melanocytes but retain neural ..
  16. Liu Y, Asan -, Ma D, Lv F, Xu X, Xia W, et al. Gene mutation spectrum and genotype-phenotype correlation in a cohort of Chinese osteogenesis imperfecta patients revealed by targeted next generation sequencing. Osteoporos Int. 2017;28:2985-2995 pubmed publisher
    ..3% of all molecularly diagnosed patients, followed by IFITM5 (n = 9, 10%), SERPINF1 (n = 4, 4.4%), WNT1 (n = 4, 4.4%), FKBP10 (n = 3, 3.3%), TMEM38B (n = 3, 3.3%), and PLOD2 (n = 1, 1.1%)...
  17. Chen H, Yang T, Wang M, Chen D, Yang Y, Zhao Y. Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-?-mediated Smad3 phosphorylation. Phytomedicine. 2018;42:207-218 pubmed publisher
    ..Additionally, MAF suppressed the expressions of Wnt1 and ?-catenin as well as its downstream target Snail1, Twist, MMP-7, PAI-1 and FSP1 expressions in NRK-52E cells...
  18. Jenwitheesuk A, Park S, Wongchitrat P, Tocharus J, Mukda S, Shimokawa I, et al. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochem Res. 2018;43:144-152 pubmed publisher
    ..g., cyclin-dependent kinase inhibitor 1B (p27)], Wingless and INT-1 (Wnt1) and inducible signaling pathway protein 1 (Wisp1) in the aged mouse hippocampus...
  19. Sahin Ersoy G, Altun Ensari T, Subas S, Giray B, Simsek E, Cevik O. WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2017;30:942-946 pubmed publisher
    To investigate Wnt1-inducible signaling pathway protein-1 (WISP1) levels and their correlation with metabolic parameters in pregnant women with gestational diabetes mellitus (GDM) and non-GDM healthy pregnant women...
  20. Yeh J, Chen C, Chiou C, Lo D, Cheng J, Kuo H. Comparison of prevalence, phenotype, and antimicrobial resistance of Salmonella serovars isolated from turkeys in Taiwan. Poult Sci. 2017;: pubmed publisher
    ..2%), cmlA (34.2%), and tet (D) (29.2%) were the most common resistance genes found in this study. The int1 gene was identified in 72...
  21. Mo L, Xiao X, Song S, Miao H, Liu S, Guo D, et al. Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway. Drug Des Devel Ther. 2015;9:2867-81 pubmed publisher
    ..and tubulointerstitial fibrosis by blocking the Wnt/β-catenin signaling pathway through inhibiting the Wnt1, β-catenin, transcription factor 4, and fibronectin 1 expressions, simultaneously measured through mRNA and ..
  22. Rudovich N, Pivovarova O, Bernigau W, Sparwasser A, Tacke C, Murahovshi V, et al. Modulation of circulating vasoactive peptides and extracellular matrix proteins are two novel mechanisms in the cardioprotective action of acarbose. Minerva Endocrinol. 2016;41:456-68 pubmed
    ..peptide (MR-proANP), C-terminal pro-endothelin-1 (CT-proET-1) and midregional pro-adrenomedullin (MR-proADM), WNT1 Inducible Signaling Pathway Protein 1 (WISP1) as well as fasting and postprandial glucose/insulin levels in the ..
  23. Elhaj Mahmoud D, Sassi N, Drissi G, Barsaoui M, Zitouna K, Sahli H, et al. sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context. Immunol Invest. 2017;46:314-328 pubmed publisher
    ..RA: rheumatoid arthritis; Wnt: Wingless; Fz: frizzled; LRP: Fz/low-density lipoprotein receptor protein; WISP1: Wnt1 inducible signaling pathway protein 1; sFRP: secreted Fz-related proteins; DKK: Dickkopf; OA: osteoarthritis; DMEM: ..
  24. Li Q, Liu X, Zhang M, Ye G, Qiao Q, Ling Y, et al. Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling. Mol Biol Rep. 2010;37:2415-21 pubmed publisher
    ..Consistently, CDK5-SV could also interact with beta-catenin as CDK5 does. Taken together, our findings suggest that CDK5-SV might also be a negative regulator of Wnt/beta-catenin signaling pathway. ..
  25. Kiesslich T, Alinger B, Wolkersdörfer G, Ocker M, Neureiter D, Berr F. Active Wnt signalling is associated with low differentiation and high proliferation in human biliary tract cancer in vitro and in vivo and is sensitive to pharmacological inhibition. Int J Oncol. 2010;36:49-58 pubmed
    ..Further investigation of the mechanism(s) of Wnt pathway activation and its inhibition may provide new molecular treatment strategies for biliary tract cancer...
  26. Subramaniam N, Sherman M, Rao R, Wilson C, Coulter S, Atkins A, et al. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/?-catenin signaling. Cancer Prev Res (Phila). 2012;5:553-61 pubmed publisher
    ..These results suggest that AICAR and metformin may confer disease-specific therapeutic benefits. ..
  27. Laine C, Joeng K, Campeau P, Kiviranta R, Tarkkonen K, Grover M, et al. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N Engl J Med. 2013;368:1809-16 pubmed publisher
    This report identifies human skeletal diseases associated with mutations in WNT1. In 10 family members with dominantly inherited, early-onset osteoporosis, we identified a heterozygous missense mutation in WNT1, c.652T?G (p.Cys218Gly)...
  28. Tang Y, Simoneau A, Liao W, Yi G, Hope C, Liu F, et al. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009;8:458-68 pubmed publisher
    ..These observations suggest a mechanism for transformation of bladder epithelium on loss of WIF1 function and provide new targets such as SKP2 for intervention in WIF1-deficient bladder cancer. ..
  29. Wang F, Guo X, Yuan T, Cao S, Rao H, Hou J, et al. Expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma. Ai Zheng. 2009;28:72-5 pubmed
    ..3%) of the 111 cases, but its expression had no effect on RFS, MFS and PFS (p > 0.05). Wnt/beta-catenin signaling pathway may be activated abnormally in some NPC patients. beta-catenin may be a prognostic factor of NPC. ..
  30. Arendt L, St Laurent J, Wronski A, Caballero S, Lyle S, Naber S, et al. Human breast progenitor cell numbers are regulated by WNT and TBX3. PLoS ONE. 2014;9:e111442 pubmed publisher
    ..cells (MEC) were isolated from reduction mammoplasty tissues and transduced with lentivirus to overexpress WNT1 or TBX3 or reduce expression of their cognate receptors using shRNA...
  31. Lin L, Yuan K, Liang X, Chen X, Zhao Z, Yang Y, et al. Occurrences and distribution of sulfonamide and tetracycline resistance genes in the Yangtze River Estuary and nearby coastal area. Mar Pollut Bull. 2015;100:304-310 pubmed publisher
    ..In the present study, sulfonamide resistance (sul), tetracycline resistance (tet) and class I integron (int1) genes were ubiquitous in the sediments of the Yangtze Estuary (YE) and nearby coastal area, and exhibited a ..
  32. van Beuge M, Ten Dam E, Werker P, Bank R. Wnt pathway in Dupuytren disease: connecting profibrotic signals. Transl Res. 2015;166:762-771.e3 pubmed publisher
    ..Immunohistochemical analysis revealed that protein expression of Wnt1-inducible secreted protein 1 (WISP1), a known Wnt target, was increased in nodules compared with control tissue, ..
  33. Keller R, Gestl S, Lu A, Hoke A, Feith D, Gunther E. Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias. Carcinogenesis. 2016;37:810-816 pubmed publisher
    ..When chemical carcinogens were employed during Wnt1-initiated mammary tumorigenesis, exposure to either 7,12-dimethylbenz(a)anthracene (DMBA) or N-ethyl-N-nitrosourea (..
  34. Tan Y, Fu R, Liu J, Wu Y, Wang B, Jiang N, et al. ADAM10 is essential for cranial neural crest-derived maxillofacial bone development. Biochem Biophys Res Commun. 2016;475:308-14 pubmed publisher
    ..Then, we crossed wnt1-cre transgenic mice with adam10-flox mice to generate ADAM10 conditional knockout mice...
  35. Barjhoux I, Gonzalez P, Baudrimont M, Cachot J. Molecular and phenotypic responses of Japanese medaka (Oryzias latipes) early life stages to environmental concentrations of cadmium in sediment. Environ Sci Pollut Res Int. 2016;23:17969-81 pubmed publisher
    ..Finally, wnt1 gene was overexpressed indicating putative deregulation of Wnt signaling pathway, and suggested to be implied in ..
  36. Schock E, Struve J, Chang C, Williams T, Snedeker J, Attia A, et al. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS ONE. 2017;12:e0174206 pubmed publisher
    ..deleted three separate intraflagellar transport genes, Kif3a, Ift88 and Ttc21b with three distinct drivers, Wnt1-Cre, Crect and AP2-Cre which drive recombination in neural crest, surface ectoderm alone, and neural crest, surface ..
  37. Thomas K, Capecchi M. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature. 1990;346:847-50 pubmed
  38. Shuai X, Zhou D, Shen T, Wu Y, Zhang J, Wang X, et al. Overexpression of the novel oncogene SALL4 and activation of the Wnt/beta-catenin pathway in myelodysplastic syndromes. Cancer Genet Cytogenet. 2009;194:119-24 pubmed publisher
    ..We therefore propose that SALL4 plays a critical role in the pathogenesis of MDS by causing the aberrant activation of the Wnt/beta-catenin pathway. ..
  39. Chen X, Song X, Yue W, Chen D, Yu J, Yao Z, et al. Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015;6:15022-34 pubmed
    ..Together, our results suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt/β-catenin signaling. ..
  40. Li J, Gao X, Ji K, Sanders A, Zhang Z, Jiang W, et al. Differential expression of CCN family members CYR611, CTGF and NOV in gastric cancer and their association with disease progression. Oncol Rep. 2016;36:2517-2525 pubmed publisher
    ..Aberrations of certain CCN members including CYR61, CTGF, Wnt1-inducible signalling pathway protein (WISP)-1 and -3 have been reported in gastric cancer...
  41. Ferrand N, Bereziat V, Moldes M, Zaoui M, Larsen A, Sabbah M. WISP1/CCN4 inhibits adipocyte differentiation through repression of PPAR? activity. Sci Rep. 2017;7:1749 pubmed publisher
    WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the CCN family able to mediate cell growth, transformation and survival in a tissue-specific manner...
  42. Winkel A, Stricker S, Tylzanowski P, Seiffart V, Mundlos S, Gross G, et al. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Cell Signal. 2008;20:2134-44 pubmed publisher
    ..Wnt-ligand binding differentially controls the Ror2/TAK1 interaction. Wnt1-binding displaces TAK1 from Ror2 while Wnt3a and Wnt5a are unable to do so thus modifying TAK1's capacity to cause ..
  43. Halifu Y, Liang J, Zeng X, Ding Y, Zhang X, Jin T, et al. Wnt1 and SFRP1 as potential prognostic factors and therapeutic targets in cutaneous squamous cell carcinoma. Genet Mol Res. 2016;15: pubmed publisher
    ..This study was designed to investigate the expression of Wnt1 and SFRP1 from the Wnt pathway in CSCC...
  44. Zheng Y, Li X, Jiang Y, Xu Y, Song B, Zhou Q, et al. Promoter hypermethylation of Wnt inhibitory factor-1 in patients with lung cancer: A systematic meta-analysis. Medicine (Baltimore). 2016;95:e5433 pubmed
    ..More investigations, including a larger number of subjects, are required to further confirm the findings of our analysis. ..
  45. Hu Q, Liu J, Wang Y, Wang J, Shi H, Sun Y, et al. Delayed-onset of progressive pseudorheumatoid dysplasia in a Chinese adult with a novel compound WISP3 mutation: a case report. BMC Med Genet. 2017;18:149 pubmed publisher
    ..Mutations in the WISP3 (Wnt1-inducible signal pathway) gene are known to be the cause of PPD...
  46. Hatzistergos K, Jiang Z, Valasaki K, Takeuchi L, Balkan W, Atluri P, et al. Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells. Stem Cells Dev. 2018;: pubmed publisher
    ..simulated microgravity experiments employing NC genetic lineage-tracing in mice with cKitCreERT2/+, Isl1nLacZ and Wnt1-Cre reporter alleles...
  47. De Gregorio R, Pulcrano S, De Sanctis C, Volpicelli F, Guatteo E, von Oerthel L, et al. miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. Stem Cell Reports. 2018;10:1237-1250 pubmed publisher
    ..Interestingly, miR-34b/c modulates Wnt1 expression, promotes cell cycle exit, and induces dopaminergic differentiation...
  48. Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, et al. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem. 2008;283:35679-88 pubmed publisher
    ..Although overexpressed Dpr1 was mainly found in the cytoplasm, endogenous Dpr1 was localized over the cell, and Wnt1 induced its nuclear export...
  49. Keupp K, Beleggia F, Kayserili H, Barnes A, Steiner M, Semler O, et al. Mutations in WNT1 cause different forms of bone fragility. Am J Hum Genet. 2013;92:565-74 pubmed publisher
    We report that hypofunctional alleles of WNT1 cause autosomal-recessive osteogenesis imperfecta, a congenital disorder characterized by reduced bone mass and recurrent fractures...
  50. Si W, Li Y, Shao H, Hu R, Wang W, Zhang K, et al. MiR-34a Inhibits Breast Cancer Proliferation and Progression by Targeting Wnt1 in Wnt/β-Catenin Signaling Pathway. Am J Med Sci. 2016;352:191-9 pubmed publisher
    ..Whether Wnt1 is a direct downstream target of miR-34a was confirmed by both bioinformatics target gene prediction and dual-..
  51. Silva G, Zhang Z, Cucco C, Oh M, Camargo C, Nor J. Lipoprotein Receptor-related Protein 6 Signaling is Necessary for Vasculogenic Differentiation of Human Dental Pulp Stem Cells. J Endod. 2017;43:S25-S30 pubmed publisher
    ..of endothelial markers and on capillary tube formation mediated by DPSCs induced with recombinant human Wnt1 (rhWnt1) and/or recombinant human vascular endothelial growth factor165 (rhVEGF165)...
  52. Gonzalez Nunez V. Role of gabra2, GABAA receptor alpha-2 subunit, in CNS development. Biochem Biophys Rep. 2015;3:190-201 pubmed publisher
    ..The expression of several genes (notch1, pax2, fgf8 and wnt1) known to contribute to the development of the central nervous system was also affected in gabra2 ..
  53. Myant K, Sansom O. Wnt/Myc interactions in intestinal cancer: partners in crime. Exp Cell Res. 2011;317:2725-31 pubmed publisher
    ..Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis. ..
  54. Kruck S, Eyrich C, Scharpf M, Sievert K, Fend F, Stenzl A, et al. Impact of an altered Wnt1/?-catenin expression on clinicopathology and prognosis in clear cell renal cell carcinoma. Int J Mol Sci. 2013;14:10944-57 pubmed publisher
    ..However, the role of Wnt1, one of the key ligands in ?-catenin regulation, is currently unknown in RCC...
  55. Wu D, Shi M, Fan X. Mechanism of miR-21 via Wnt/β-catenin signaling pathway in human A549 lung cancer cells and Lewis lung carcinoma in mice. Asian Pac J Trop Med. 2015;8:479-84 pubmed publisher
    ..Correlation among key molecules (Wnt1, β-catenin, CyclinD1 and miR-21) of mRNA and protein levels in Wnt/β-catenin signaling pathway were studied ..
  56. Oh S, You E, Ko P, Jeong J, Keum S, Rhee S. Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling. Biochem Biophys Res Commun. 2017;482:8-14 pubmed publisher
    ..a regulator of ?-tubulin acetylation, is required for colon cancer proliferation and invasion via regulation of Wnt1 and its downstream genes expression...
  57. Huang A, Yang Y, Chen S, Xia F, Sun D, Fang D, et al. MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1. Oncotarget. 2017;8:17191-17201 pubmed publisher
    ..Luciferase report assay and Western blot experiments demonstrated that WNT1 is the direct target of miR-34a in DCs...
  58. Shi Z, Deng J, Fu S, Wang L, Wang Q, Liu B, et al. Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway. Int J Mol Med. 2017;40:1699-1708 pubmed publisher
    ..In addition, the upstream proteins (Wnt1 and Wnt3a), downstream proteins (Dvl2, β-catenin) and target proteins (C-myc and cyclin D) in the Wnt/β-..
  59. van Ooyen A, Kwee V, Nusse R. The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. EMBO J. 1985;4:2905-9 pubmed
    ..The conservation between the mouse and the human int-1 genes is not restricted to exons; extensive parts of the introns are also homologous. Thus, int-1 ranks among the most conserved genes known, a property shared with other oncogenes. ..
  60. Parada C, Han D, Grimaldi A, Sarrión P, Park S, Pelikan R, et al. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015;142:3734-45 pubmed publisher
    ..of ERK2 (MAPK1) in the postmigratory neural crest populating the craniofacial region, we studied two mouse models: Wnt1-Cre;Erk2(fl/fl) and Osr2-Cre;Erk2(fl/fl)...
  61. Ma X, Yan W, Dai Z, Gao X, Ma Y, Xu Q, et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/?-catenin pathway. Drug Des Devel Ther. 2016;10:1419-41 pubmed publisher
    ..Baicalein also downregulated the expression of Wnt1 and ?-catenin proteins and transcription level of Wnt/?-catenin-targeted genes...
  62. Jia S, Qu T, Feng M, Ji K, Li Z, Jiang W, et al. Association of Wnt1-inducible signaling pathway protein-1 with the proliferation, migration and invasion in gastric cancer cells. Tumour Biol. 2017;39:1010428317699755 pubmed publisher
    b>Wnt1-inducible signaling pathway protein-1 is a cysteine-rich protein that belongs to the CCN family, which has been implicated in mediating the occurrence and progression through distinct molecular mechanisms in several tumor types...
  63. Sawada H, Rateri D, Moorleghen J, Majesky M, Daugherty A. Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:1722-1726 pubmed publisher
    ..Mice with repressed LacZ in the ROSA26 locus were bred to those expressing Cre controlled by either the Wnt1 or Mef2c (myocyte-specific enhancer factor 2c) promoter to trace CNC- and SHF-derived SMCs, respectively...
  64. Jing H, Su X, Gao B, Shuai Y, Chen J, Deng Z, et al. Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis. Cell Death Dis. 2018;9:176 pubmed publisher
    ..Accordingly, histone acetylation levels on Wnt genes (Wnt1, Wnt6, Wnt10a, and Wnt10b) were declined in BMSCs from OVX mice...
  65. Sun C, Wu K, Lee H, Uen Y, Tian Y, Tzeng C, et al. Anti-sense morpholino oligonucleotide assay shows critical involvement for NF-kappaB activation in the production of Wnt-1 protein by HepG2 cells: oncology implications. J Biomed Sci. 2008;15:633-43 pubmed publisher
    ..In summary, NF-kappaB activation is critically involved in the production of Wnt-1 by HepG2 cells. These results may have important oncology implications in treating patients with NF-kappaB-associated Wnt-1-producing cancers. ..
  66. Tang X, Lin L, Song L, Tang X. Hypoxia-inducible miR-152 suppresses the expression of WNT1 and ERBB3, and inhibits the proliferation of cervical cancer cells. Exp Biol Med (Maywood). 2016;241:1429-37 pubmed publisher
    ..A bioinformatic tool predicted that WNT1 and ERBB3 were target genes of miR-152. This was confirmed by dual luciferase assays and Western blots...
  67. Chen J, Jia Y, Liu G, Sun Q, Zhang F, Ma S, et al. Role of LncRNA TUG1 in intervertebral disc degeneration and nucleus pulposus cells via regulating Wnt/?-catenin signaling pathway. Biochem Biophys Res Commun. 2017;491:668-674 pubmed publisher
    ..TUG1 was upregulated in patients with IDD, which was positively related to Wnt and ?-catenin. Besides, TUG1, Wnt1 and ?-catenin were greatly increased in the NPCs after TNF-? induction...
  68. Zhou H, Yao Y, Liang Y, Wang Z, Zhou X, Guo W, et al. [Screening of key molecules of HAb18G/CD147 signal transduction pathway in human hepatoma cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1196-1200 pubmed
    ..HAb18G/CD147, the down-regulated genes included bone morphogenetic protein-2 (BMP-2), BMP-5, endothelin-1 (ET-1), Wnt1-induced signaling proteins-2/CCN5 (WISP-2), cysteine-rich 61/CCN1 (Cyr61), prostate stem cell antigen (PSCA), and ..
  69. Zhu Y, Wang Y, Zhou S, Jiang X, Ma X, Liu C. Robust performance of a membrane bioreactor for removing antibiotic resistance genes exposed to antibiotics: Role of membrane foulants. Water Res. 2018;130:139-150 pubmed publisher
    ..of membrane fouling after antibiotic exposure, five typical ARG subtypes (sulI, sulII, tetC, tetX and ereA) and int1 were quantified affiliated by systematic membrane foulants analysis in a laboratory-scale anoxic/aerobic membrane ..
  70. Qin D, Yan Y, Hu B, Zhang W, Li H, Li X, et al. Wisp2 disruption represses Cxcr4 expression and inhibits BMSCs homing to injured liver. Oncotarget. 2017;8:98823-98836 pubmed publisher
    ..b>Wnt1 inducible signaling pathway protein 2 (Wisp2) is highly expressed in BMSCs, however, its function remains unclear...
  71. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, et al. LDL-receptor-related proteins in Wnt signal transduction. Nature. 2000;407:530-5 pubmed
    ..The extracellular domain of LRP6 bound Wnt-1 and associated with Fz in a Wnt-dependent manner. Our results indicate that LRP6 may be a component of the Wnt receptor complex. ..
  72. Tice D, Szeto W, Soloviev I, Rubinfeld B, Fong S, Dugger D, et al. Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling. J Biol Chem. 2002;277:14329-35 pubmed
    ..In principal, the therapeutic index of antibodies directed against these antigens should be enhanced by co-administration of retinoic acid. ..
  73. Yau T, Chan C, Chan K, Lee M, Wong C, Fan S, et al. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene. 2005;24:1607-14 pubmed
    ..To conclude, downregulation of HDPR1 is common in HCCs, frequently involves hypermethylation of the promoter region, and allelic loss of the HDPR1 locus may also play a role. ..
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    ..In the brief review, we recount mounting evidence that points to oxidative stress as a major contributor to the pathobiology of diabetic arterial calcification. ..
  75. Cairo S, Armengol C, de Reynies A, Wei Y, Thomas E, Renard C, et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell. 2008;14:471-84 pubmed publisher
    ..Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy. ..
  76. Akaboshi S, Watanabe S, Hino Y, Sekita Y, Xi Y, Araki K, et al. HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer. Am J Pathol. 2009;175:1675-85 pubmed publisher
    ..expressing endogenous HMGA1 fused to enhanced green fluorescent protein were generated and then crossed with K19-Wnt1/C2mE mice, which develop gastric tumors through activation of both the Wnt and prostaglandin E2 pathways...
  77. Zhang L, Li K, Lv Z, Xiao X, Zheng J. The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line. Pediatr Surg Int. 2009;25:1065-71 pubmed publisher
    ..role that Wnt/beta-catenin plays in human neuroblastoma cell line SH-SY5Y, including detection of expression of wnt1 and beta-catenin in SH-SY5Y, and the morphological and proliferative changes after Wnt1 RNAi in SH-SY5Y...
  78. Tinsley H, Gary B, Keeton A, Lu W, Li Y, Piazza G. Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/?-catenin-mediated transcription in human breast tumor cells. Cancer Prev Res (Phila). 2011;4:1275-84 pubmed publisher
    ..We conclude that PDE5 represents a novel molecular target for the discovery of safer and more efficacious drugs for breast cancer chemoprevention. ..
  79. Song K, Li G, Kim J, Jing K, Kim T, Kim J, et al. Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/?-catenin in SW480 human colon cancer cells. BMC Cancer. 2011;11:307 pubmed publisher
    ..These data suggest that PL suppresses tumor growth, invasion, and angiogenesis through the inhibition of Wnt/?-catenin signaling in certain colon cancer cells. ..
  80. D Alimonte I, Lannutti A, Pipino C, Di Tomo P, Pierdomenico L, Cianci E, et al. Wnt signaling behaves as a "master regulator" in the osteogenic and adipogenic commitment of human amniotic fluid mesenchymal stem cells. Stem Cell Rev. 2013;9:642-54 pubmed publisher
  81. Goksel G, Bilir A, Uslu R, Akbulut H, Guven U, Oktem G. WNT1 gene expression alters in heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+ prostate cancer stem cell spheroids. J BUON. 2014;19:207-14 pubmed
    ..The expression levels of WNT1, FZD1, ADAR, APC, AXIN, BTRC, FRAT1 and PPARD genes were measured by polymerase chain reaction (PCR) array assay ..
  82. Wang G, Zhao Y, Zheng Y. MiR-122/Wnt/?-catenin regulatory circuitry sustains glioma progression. Tumour Biol. 2014;35:8565-72 pubmed publisher
    ..Taken together, we revealed that there is a miR-122/Wnt/?-catenin regulatory circuitry existing in glioma cells that contributes to glioma progression. ..
  83. Cao J, Tsenovoy P, Thompson E, Falck J, Touchon R, Sodhi K, et al. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. Prostaglandins Other Lipid Mediat. 2015;116-117:76-86 pubmed publisher
    ..Emerging studies implicate Wnt1 signaling in the formation of new blood vessels...
  84. Sun Q, Guo S, Wang C, Sun X, Wang D, Xu N, et al. Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation. Int J Clin Exp Pathol. 2015;8:7631-9 pubmed
    ..01). It is possible that there is a complicated interaction between the two signal pathways in pathological scar formation (both synergy and antagonism). ..
  85. Galli L, Zebarjadi N, Li L, Lingappa V, Burrus L. Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling. Exp Cell Res. 2016;347:171-83 pubmed publisher
    ..We first investigated possible interactions between PORCN, WLS, and WNT1, by carrying out co-immunoprecipitation studies...
  86. Won J, Jang W, Lee H, Park S, Kim W, Park J, et al. Novel missense loss-of-function mutations of WNT1 in an autosomal recessive Osteogenesis imperfecta patient. Eur J Med Genet. 2017;60:411-415 pubmed publisher
    ..Recently, loss-of-function mutations of WNT1 have been reported to be causative in OI or osteoporosis...
  87. Wang F, Wang Q, Li C, Yu P, Qu Y, Zhou L. The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia. Neuroscience. 2017;359:267-276 pubmed publisher
    ..Here we assessed the role of Celsr3 in DRG using conditional gene inactivation in crosses with Wnt1-Cre mice...
  88. Rivera Yañez C, Terrazas L, Jimenez Estrada M, Campos J, Flores Ortiz C, Hernandez L, et al. Anti-Candida Activity of Bursera morelensis Ramirez Essential Oil and Two Compounds, ?-Pinene and ?-Terpinene-An In Vitro Study. Molecules. 2017;22: pubmed publisher
    ..94% (8.0 mg/mL). Furthermore, it was observed that the essential oil diminishes the transcription of the gene INT1. This work provides evidence that confirms the anti-Candida activity of the B...
  89. McMahon A, Moon R. int-1--a proto-oncogene involved in cell signalling. Development. 1989;107 Suppl:161-7 pubmed
    ..This results in a striking and specific aberration, bifurcation of the anterior neural tube. Thus, it seems possible that in vertebrates int-1 is able to influence patterning events. ..
  90. Cheng C, Smith S, Charnock Jones D. Wnt-1 signaling inhibits human umbilical vein endothelial cell proliferation and alters cell morphology. Exp Cell Res. 2003;291:415-25 pubmed
    ..They also suggest that Wnt signaling might participate in angiogenesis by regulating endothelial cell growth and function. ..
  91. Driskell R, Liu X, Luo M, Filali M, Zhou W, Abbott D, et al. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004;287:L752-63 pubmed
    ..These findings suggest that Wnt regulation of the Lef-1 promoter at the WRE may play an important role during airway submucosal glandular bud formation. ..
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