WNK1

Summary

Gene Symbol: WNK1
Description: WNK lysine deficient protein kinase 1
Alias: HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65, serine/threonine-protein kinase WNK1, WNK lysine deficient protein kinase 1 isoform, erythrocyte 65 kDa protein, prostate-derived sterile 20-like kinase, protein kinase with no lysine 1, protein phosphatase 1, regulatory subunit 167, serine/threonine-protein kinase WNK1 1, serine/threonine-protein kinase WNK1 2
Species: human
Products:     WNK1

Top Publications

  1. Verissimo F, Jordan P. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene. 2001;20:5562-9 pubmed
    ..The same amino acid alteration was recently described for rat WNK1 (with no K=lysine) in which another nearby lysine residue was shown to confer kinase activity to the protein...
  2. Xu B, Min X, Stippec S, Lee B, Goldsmith E, Cobb M. Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem. 2002;277:48456-62 pubmed
    ..hypotheses about the position of the catalytic lysine, and we examined mechanisms involved in the regulation of WNK1 activity...
  3. Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, et al. Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS ONE. 2009;4:e5003 pubmed publisher
    b>WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH)...
  4. Zagorska A, Pozo Guisado E, Boudeau J, Vitari A, Rafiqi F, Thastrup J, et al. Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. J Cell Biol. 2007;176:89-100 pubmed
    Mutations within the WNK1 (with-no-K[Lys] kinase-1) gene cause Gordon's hypertension syndrome. Little is known about how WNK1 is regulated...
  5. Ohta A, Schumacher F, Mehellou Y, Johnson C, Knebel A, MacArtney T, et al. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J. 2013;451:111-22 pubmed publisher
    ..Strikingly, 13 out of the 15 dominant KLHL3 disease mutations analysed inhibited binding to WNK1 or CUL3...
  6. Osada Y, Miyauchi R, Goda T, Kasezawa N, Horiike H, Iida M, et al. Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination. J Hum Genet. 2009;54:474-8 pubmed publisher
    WNK lysine-deficient protein kinase 1 (WNK1) is a member of the WNK family of serine/threonine kinases with no lysine (K), and these kinases have been implicated as important modulators of salt homeostasis in the kidney...
  7. Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C. LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension. J Biol Chem. 2009;284:15717-28 pubmed publisher
    ..In the present study, a novel interaction between LINGO-1 and a serine-threonine kinase WNK1 was identified by yeast two-hybrid screen...
  8. Tu S, Bugde A, Luby Phelps K, Cobb M. WNK1 is required for mitosis and abscission. Proc Natl Acad Sci U S A. 2011;108:1385-90 pubmed publisher
    ..RNA interference screens have implicated WNKs in survival and growth, and WNK1 is essential for viability of mice...
  9. Putku M, Kepp K, Org E, Sõber S, Comas D, Viigimaa M, et al. Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans. Hum Mutat. 2011;32:806-14 pubmed publisher
    Mutations in WNK1 and WNK4 cause familial hypertension, the Gordon syndrome. WNK1 and WNK4 conserved noncoding regions were targeted to polymorphism screening using DHPLC and DGGE...

More Information

Publications87

  1. Vitari A, Thastrup J, Rafiqi F, Deak M, Morrice N, Karlsson H, et al. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J. 2006;397:223-31 pubmed
    ..Recent studies indicated that SPAK and OSR1 are phosphorylated and activated by the WNK1 [with no K (lysine) protein kinase-1] and WNK4, genes mutated in humans affected by Gordon's hypertension syndrome...
  2. Lazrak A, Liu Z, Huang C. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A. 2006;103:1615-20 pubmed
    ..Intronic deletions with increased expression of a ubiquitous long WNK1 transcript cause pseudohypoaldosteronism type 2 (PHA II), characterized by hypertension and hyperkalemia...
  3. Subramanya A, Yang C, Zhu X, Ellison D. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Am J Physiol Renal Physiol. 2006;290:F619-24 pubmed
    With-no-lysine kinase-1 (WNK1) gene mutations cause familial hyperkalemic hypertension (FHHt), a Mendelian disorder of excessive renal Na+ and K+ retention...
  4. Turner S, Schwartz G, Chapman A, Boerwinkle E. WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension. 2005;46:758-65 pubmed
    ..After adjustment for ethnicity, sex, age, and waist-to-hip ratio, 3 SNPs in WNK1 (rs2107614, rs2277869, and rs1159744), encoding a lysine-deficient protein kinase that regulates thiazide-sensitive ..
  5. Xu B, Lee B, Min X, Lenertz L, Heise C, Stippec S, et al. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Res. 2005;15:6-10 pubmed
    ..Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive ..
  6. Delaloy C, Lu J, Houot A, Disse Nicodeme S, Gasc J, Corvol P, et al. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol. 2003;23:9208-21 pubmed
    b>WNK1 is a serine-threonine kinase, the expression of which is affected in pseudohypoaldosteronism type II, a Mendelian form of arterial hypertension...
  7. Wilson F, Disse Nicodeme S, Choate K, Ishikawa K, Nelson Williams C, Desitter I, et al. Human hypertension caused by mutations in WNK kinases. Science. 2001;293:1107-12 pubmed
    ..Both genes encode members of the WNK family of serine-threonine kinases. Disease-causing mutations in WNK1 are large intronic deletions that increase WNK1 expression...
  8. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, et al. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem. 2005;280:42685-93 pubmed
    The WNK1 and WNK4 genes have been found to be mutated in some patients with hyperkalemia and hypertension caused by pseudohypoaldosteronism type II...
  9. Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, et al. Wnk kinases are positive regulators of canonical Wnt/?-catenin signalling. EMBO Rep. 2013;14:718-25 pubmed publisher
    ..Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a ..
  10. Tobin M, Timpson N, Wain L, Ring S, Jones L, Emmett P, et al. Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children. Hypertension. 2008;52:974-9 pubmed publisher
    b>WNK1 gene variants have been associated with adult blood pressure. We aimed to investigate relationships between WNK1 variants and blood pressure, as well as blood pressure change with age, in a longitudinal childhood study...
  11. Anselmo A, Earnest S, Chen W, Juang Y, Kim S, Zhao Y, et al. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci U S A. 2006;103:10883-8 pubmed
    ..OSR1 exists in a complex with WNK1 in cells, is activated by recombinant WNK1 in vitro, and is phosphorylated in a WNK1-dependent manner in cells...
  12. Cun Y, Li J, Tang W, Sheng X, Yu H, Zheng B, et al. Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China. J Genet Genomics. 2011;38:165-71 pubmed publisher
    The association of polymorphisms in exon 1 of the WNK1 gene with essential hypertension in the minority groups of Hani and Yi of China was investigated in the case-control study...
  13. de los Heros P, Alessi D, Gourlay R, Campbell D, Deak M, MacArtney T, et al. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. Biochem J. 2014;458:559-73 pubmed publisher
  14. Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, et al. KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013;437:457-62 pubmed publisher
    Mutations in the WNK1 and WNK4 genes result in an inherited hypertensive disease, pseudohypoaldosteronism type II (PHAII). Recently, the KLHL3 and Cullin3 genes were also identified as responsible genes for PHAII...
  15. Vitari A, Deak M, Collins B, Morrice N, Prescott A, Phelan A, et al. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J. 2004;378:257-68 pubmed
    Recent evidence indicates that mutations in the gene encoding the WNK1 [with no K (lysine) protein kinase-1] results in an inherited hypertension syndrome called pseudohypoaldosteronism type II...
  16. Xu B, Stippec S, Lenertz L, Lee B, Zhang W, Lee Y, et al. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem. 2004;279:7826-31 pubmed
    b>WNK1 belongs to a unique protein kinase family that lacks the catalytic lysine in its normal position. Mutations in human WNK1 and WNK4 have been implicated in causing a familial form of hypertension...
  17. Shekarabi M, Girard N, Rivi re J, Dion P, Houle M, Toulouse A, et al. Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II. J Clin Invest. 2008;118:2496-505 pubmed publisher
    ..Mutations in hereditary sensory neuropathy type II (HSN2), a single-exon ORF originally identified in affected families in Quebec and Newfoundland, Canada, were found to ..
  18. An S, Cha S, Yoon J, Chang S, Ross E, Huang C. WNK1 promotes PIP? synthesis to coordinate growth factor and GPCR-Gq signaling. Curr Biol. 2011;21:1979-87 pubmed publisher
    ..b>WNK1 protein kinase is known to regulate ion homeostasis and cause hypertension when expression is increased by gene ..
  19. NARAY FEJES TOTH A, Snyder P, Fejes Toth G. The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci U S A. 2004;101:17434-9 pubmed
    b>WNK1 belongs to a unique family of Ser/Thr kinases that have been implicated in the control of blood pressure...
  20. Tobin M, Raleigh S, Newhouse S, Braund P, Bodycote C, Ogleby J, et al. Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation. 2005;112:3423-9 pubmed
    Blood pressure (BP) is a heritable trait of major public health concern. The WNK1 and WNK4 genes, which encode proteins in the WNK family of serine-threonine kinases, are involved in renal electrolyte homeostasis...
  21. Shibata S, Zhang J, Puthumana J, Stone K, Lifton R. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci U S A. 2013;110:7838-43 pubmed publisher
    ..By MS and coimmunoprecipitation, we show that KLHL3 normally binds to WNK1 and WNK4, members of WNK (with no lysine) kinase family that have previously been found mutated in PHAII...
  22. Lafreniere R, MacDonald M, Dube M, MacFarlane J, O Driscoll M, Brais B, et al. Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates. Am J Hum Genet. 2004;74:1064-73 pubmed
    ..This gene, termed "HSN2," consists of a single exon located within intron 8 of the PRKWNK1 gene and is transcribed from the same strand...
  23. Coen K, Pareyson D, Auer Grumbach M, Buyse G, Goemans N, Claeys K, et al. Novel mutations in the HSN2 gene causing hereditary sensory and autonomic neuropathy type II. Neurology. 2006;66:748-51 pubmed
    Hereditary sensory and autonomic neuropathy type II (HSAN-II) is caused by recessive mutations in the HSN2 gene assigned to chromosome 12p13.33...
  24. Lenertz L, Lee B, Min X, Xu B, Wedin K, Earnest S, et al. Properties of WNK1 and implications for other family members. J Biol Chem. 2005;280:26653-8 pubmed
    ..Of the four human WNK family members, WNK1 and WNK4 have been linked to a hereditary form of hypertension, pseudohypoaldosteronism type II...
  25. Parvez M. Mutational analysis of hepatitis E virus ORF1 "Y-domain": Effects on RNA replication and virion infectivity. World J Gastroenterol. 2017;23:590-602 pubmed publisher
    ..i>In vitro transcribed mRNA (pSK-GFP) constructs were transfected into S10-3 cells and viral RNA replicating GFP-positive cells were scored by ..
  26. Hu C, Mutailipu M, Wang Y, Guo F, Yang Z, Pan S. The activity of lone pair contributing to SHG response in bismuth borates: a combination investigation from experiment and DFT calculation. Phys Chem Chem Phys. 2017;19:25270-25276 pubmed publisher
    ..series of bismuth borates which exhibit an apparent hierarchy in SHG response: BiB2O4F (12 × KDP), ?-BiB3O6 (8...
  27. Tanudjaja E, Hoshi N, Su Y, Hamamoto S, Uozumi N. Kup-mediated Cs+ uptake and Kdp-driven K+ uptake coordinate to promote cell growth during excess Cs+ conditions in Escherichia coli. Sci Rep. 2017;7:2122 pubmed publisher
    ..coli. Cells lacking Kdp, TrkG and TrkH but expressing Kup grew less well when Cs+ was increased in the medium...
  28. Shi C, Dubois M, Wang Y, Zhang X. High-speed acoustic communication by multiplexing orbital angular momentum. Proc Natl Acad Sci U S A. 2017;114:7250-7253 pubmed publisher
    ..communication modulation techniques like quadrature amplitude modulation (QAM) and phase-shift keying (PSK)...
  29. Kahle K, Schmouth J, Lavastre V, Latremoliere A, Zhang J, Andrews N, et al. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Sci Signal. 2016;9:ra32 pubmed publisher
    ..The HSN2-containing splice variant is referred to as WNK1/HSN2...
  30. Reiling Steffensmeier C, Marky L. The Complementarity of the Loop to the Stem in DNA Pseudoknots Gives Rise to Local TAT Base-Triplets. Methods Enzymol. 2016;567:413-32 pubmed publisher
    ..pseudoknots with the following sequence: d(TCTCTTnAAAAAAAAGAGAT5TTTTTTT), where "Tn" is a thymine loop with n=5 (PsK-5), 7 (PsK-7), 9 (PsK-9), or 11 (PsK-11)...
  31. Adams N, Vasquez Y, Mo Q, Gibbons W, Kovanci E, DeMayo F. WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation, and migration in part through mitogen-activated protein kinase 7. Biol Reprod. 2017;97:400-412 pubmed publisher
    ..The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization...
  32. Fu Y, Subramanya A, Rozansky D, Cohen D. WNK kinases influence TRPV4 channel function and localization. Am J Physiol Renal Physiol. 2006;290:F1305-14 pubmed
    ..The effect of the related kinase WNK1 on TRPV4 function and surface expression was similar to that of WNK4...
  33. Tsai M, Chang W, Tsai P, Wu C, Ho Y, Yen M, et al. Montelukast Induces Apoptosis-Inducing Factor-Mediated Cell Death of Lung Cancer Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..Montelukast also markedly decreased the phosphorylation of several proteins, such as with no lysine 1 (WNK1), protein kinase B (Akt), extracellular signal-regulated kinase 1/2 (Erk1/2), MAPK/Erk kinase (MEK), and proline-..
  34. Rosado Toro J, Barr T, Galons J, Marron M, Stopeck A, Thomson C, et al. Automated breast segmentation of fat and water MR images using dynamic programming. Acad Radiol. 2015;22:139-48 pubmed publisher
    ..The third segmentation algorithm uses k-means++ and dynamic programming (KDP) for finding the breast pixels...
  35. Scarpari M, Reverberi M, Parroni A, Scala V, Fanelli C, Pietricola C, et al. Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects. PLoS ONE. 2017;12:e0171412 pubmed publisher
    ..g. plectasin), immune system stimulator (e,g, lentinan), antitumor agents (e.g. krestin, PSK) and hypolipidemic agents (e.g. lovastatin) inter alia...
  36. Okuno K, Aoyama T, Oba K, Yokoyama N, Matsuhashi N, Kunieda K, et al. Randomized phase III trial comparing surgery alone to UFT + PSK for stage II rectal cancer (JFMC38 trial). Cancer Chemother Pharmacol. 2018;81:65-71 pubmed publisher
    We conducted a randomized phase III trial comparing tegafur/uracil (UFT) and Polysaccharide-K (PSK) to surgery alone in curatively resected stage II rectal cancer patients...
  37. Jiang J, Zhang L, Huang Y, Sun Z, Pan Y, Mi J. KB(PO4)F: a novel acentric deep-ultraviolet material. Dalton Trans. 2017;46:1677-1683 pubmed publisher
    ..of less than 200 nm and a large second-harmonic generation (SHG) effect similar to KH2PO4 (KDP), hence representing a new promising deep-ultraviolet NLO material...
  38. Hu J, Ma Z, Sa R, Zhang Y, Wu K. Theoretical perspectives on the structure, electronic, and optical properties of titanosilicates Li2M4[(TiO)Si4O12] (M = K+, Rb+). Phys Chem Chem Phys. 2017;19:15120-15128 pubmed publisher
    ..5 times higher than KDP)...
  39. Webb T, Carrisoza Gaytán R, Montalbetti N, Rued A, Roy A, Socovich A, et al. Cell-specific regulation of L-WNK1 by dietary K. Am J Physiol Renal Physiol. 2016;310:F15-26 pubmed publisher
    ..This disorder is linked to mutations in genes encoding with-no-lysine kinase 1 (WNK1), WNK4, and Kelch-like 3/Cullin 3, two components of an E3 ubiquitin ligase complex that degrades WNKs...
  40. Han Y, Fan X, Sun K, Wang X, Wang Y, Chen J, et al. Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response. Clin Biochem. 2011;44:1045-1049 pubmed publisher
    ..Two WNK1 and one WNK4 polymorphisms were detected in two independent populations (n = 1592 and 602) for association with ..
  41. Chung W, Han J, Heo W, Lee M, Kim J. Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2. Mol Cell Biochem. 2018;447:165-174 pubmed publisher
    ..In this study, we discovered that WNK1 and WNK4 in POMC-expressing neuronal cells in WNK1 overexpressed transgenic mice (WNK1 TG) decrease appetite via ..
  42. Park D, Pagán V, Cho P, Luo J, Jen A, Petruzzi P. RF photonic downconversion of vector modulated signals based on a millimeter-wave coupled electrooptic nonlinear polymer phase-modulator. Opt Express. 2017;25:29885-29895 pubmed publisher
    ..We demonstrate experimental results with QPSK, 8-PSK, 16-QAM, 32-QAM, and 64-QAM millimeter-wave signals centered at 36 GHz...
  43. Dorwart M, Shcheynikov N, Wang Y, Stippec S, Muallem S. SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol. 2007;584:333-45 pubmed
    ..Co-expression of SLC26A9 with the WNK kinases WNK1, WNK3 or WNK4 inhibited SLC26A9 activity, and the inhibition was independent of WNK kinase activity...
  44. Liu F, Lian Q, Ren J, Ren K, Wang Y, Wang D, et al. Lack of family-based association between common variations in WNK1 and blood pressure level. Med Sci Monit. 2014;20:1958-62 pubmed publisher
    b>WNK1 (With No-lysine Kinase 1) modulates numerous sodium transport-related ion channels involved in regulation of blood pressure...
  45. . Failure to validate association between 12p13 variants and ischemic stroke. N Engl J Med. 2010;362:1547-50 pubmed publisher
  46. Costa V, Esposito R, Ziviello C, Sepe R, Bim L, Cacciola N, et al. New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. Oncotarget. 2015;6:11242-51 pubmed
    ..We identified a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression...
  47. Zhou Y, Sun W, Chen N, Xu C, Wang X, Dong K, et al. Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis. Oncotarget. 2017;8:66328-66342 pubmed publisher
    ..Further results suggested that NKCC1 promotes the invasion ability via MMP-2 activity, and that the WNK1/OSR1/NKCC1 signal pathway might play roles in HCC metastasis...
  48. Toda Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota D, Kohsaka S, et al. Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. Mod Pathol. 2016;29:1424-1432 pubmed publisher
    ..cells with mutant PPP2R1A induced an accelerated growth rate via increased phosphorylation of Akt1/2, ERK1/2, and WNK1, a kinase associated with angiogenesis...
  49. Kaiser U, Sabatowski R, Balck F. [Patient first - The impact of characteristics of target populations on decisions about therapy effectiveness of complex interventions: Psychological variables to assess effectiveness in interdisciplinary multimodal pain therapy]. Z Evid Fortbild Qual Gesundhwes. 2017;125:48-59 pubmed publisher
    ..identify differences in depressive symptoms (HADS-D), general anxiety (HADS-A), and mental quality of life (SF 36 PSK) at the time of therapy admission and their development estimated by means of effect sizes...
  50. Wei Q, Sun L, Zhang J, Yang G. Two deep-ultraviolet nonlinear optical alkaline-earth metal borates based on different types of oxoboron clusters. Dalton Trans. 2017;46:7911-7916 pubmed publisher
    ..3 and ?0.8 times that of KDP (KH2PO4), respectively...
  51. Liu F, Zheng S, Mu J, Chu C, Wang L, Wang Y, et al. Common variation in with no-lysine kinase 1 (WNK1) and blood pressure responses to dietary sodium or potassium interventions- family-based association study. Circ J. 2013;77:169-74 pubmed
    Common variations in the gene with no-lysine kinase 1 (WNK1) are associated with hypertension, but because of gene-environment interaction, it is difficult to fully identify the genetic contribution of WNK1 gene polymorphism to blood ..
  52. Manunta P, Lavery G, Lanzani C, Braund P, Simonini M, Bodycote C, et al. Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation. Hypertension. 2008;52:366-72 pubmed publisher
    ..In previous studies, variants in the genes for alpha-adducin (ADD1), WNK1, and NEDD4L, which all regulate renal sodium absorption, have been associated with increased BP...
  53. Rivière J, Dion P, Shekarabi M, Girard N, Faivre L, Lafreniere R, et al. [Mutations in the HSN2 exon of WNK1 cause hereditary sensory neuropathy type II]. Med Sci (Paris). 2009;25:235-8 pubmed publisher
  54. Gallolu Kankanamalage S, Lee A, Wichaidit C, Lorente Rodríguez A, Shah A, Stippec S, et al. Multistep regulation of autophagy by WNK1. Proc Natl Acad Sci U S A. 2016;113:14342-14347 pubmed
    ..Of the four mammalian WNKs, only WNK1 is expressed throughout the body...
  55. Xu B, Stippec S, Chu P, Lazrak A, Li X, Lee B, et al. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A. 2005;102:10315-20 pubmed
    ..Intronic deletions increase the expression of WNK1 in humans and cause pseudohypoaldosteronism type II, a form of hypertension...
  56. Sinđić A, Sussman C, Romero M. Primers on molecular pathways: bicarbonate transport by the pancreas. Pancreatology. 2010;10:660-3 pubmed publisher
    ..Most recently, both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers. and IAP. ..
  57. Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer Grumbach M, Levy N, et al. Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. Brain. 2009;132:2699-711 pubmed publisher
    ..two genes for autosomal dominant (SPTLC1 and RAB7) and five genes for autosomal recessive forms of HSAN (WNK1/HSN2, NTRK1, NGFB, CCT5 and IKBKAP)...
  58. Delaloy C, Elvira Matelot E, Clemessy M, Zhou X, Imbert Teboul M, Houot A, et al. Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues. Hypertension. 2008;52:1149-54 pubmed publisher
    Large deletions in intron 1 of the with-no-lysine kinase type 1 (WNK1) gene cause familial hyperkalemic hypertension...
  59. Piala A, Moon T, Akella R, He H, Cobb M, Goldsmith E. Chloride sensing by WNK1 involves inhibition of autophosphorylation. Sci Signal. 2014;7:ra41 pubmed publisher
    b>WNK1 [with no lysine (K)] is a serine-threonine kinase associated with a form of familial hypertension...
  60. Zhu W, Begum G, Pointer K, Clark P, Yang S, Lin S, et al. WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Mol Cancer. 2014;13:31 pubmed publisher
    ..Expression of NKCC1 and its upstream kinases With-No-K (Lysine) kinase 1 (WNK1) and oxidative stress-responsive kinase-1 (OSR1) in different human glioma cell lines and glioma specimens were ..
  61. Heise C, Xu B, Deaton S, Cha S, Cheng C, Earnest S, et al. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem. 2010;285:25161-7 pubmed publisher
    ..Mutations in two WNKs cause a heritable form of ion imbalance culminating in hypertension. WNK1 activates the serum- and glucocorticoid-induced protein kinase SGK1; the mechanism is noncatalytic...
  62. He G, Wang H, Huang S, Huang C. Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest. 2007;117:1078-87 pubmed
    ..Mutations of 2 family members, WNK1 and WNK4, cause pseudohypoaldosteronism type 2 (PHA2), an autosomal-dominant disease characterized by hypertension ..
  63. Li F, Xie X, Tie G, Hu H, Zhou L. Figuring process of potassium dihydrogen phosphate crystal using ion beam figuring technology. Appl Opt. 2017;56:7130-7137 pubmed publisher
    ..figuring (IBF) technology has presented many excellent performances in figuring potassium dihydrogen phosphate (KDP) crystals, such as it is a noncontact figuring process and it does not require polishing fluid...
  64. Dolzhenkova E, Kostenyukova E, Bezkrovnaya O, Pritula I. Effect of doping of KDP crystal with amino acid l-arginine on the strength properties and character of laser damage. J Cryst Growth. 2017;478:111-116 pubmed publisher
    Studied were the strength characteristics of KDP crystals doped with l-arginine under a concentrated load and irradiation of the first harmonic YAG:Nd3+ laser...
  65. Dani P, Ujaoney A, Apte S, Basu B. Regulation of potassium dependent ATPase (kdp) operon of Deinococcus radiodurans. PLoS ONE. 2017;12:e0188998 pubmed publisher
    The genome of D. radiodurans harbors genes for structural and regulatory proteins of Kdp ATPase, in an operon pattern, on Mega plasmid 1. Organization of its two-component regulatory genes is unique...
  66. Susa K, Sohara E, Takahashi D, Okado T, Rai T, Uchida S. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3. Biochem Biophys Res Commun. 2017;491:727-732 pubmed publisher
    ..mice, a PHAII model, exhibited augmented activation of OSR1/SPAK-NCC signaling by increased protein levels of both WNK1 and WNK4 due to impaired protein degradation by the mutant KLHL3...
  67. Villa F, Goebel J, Rafiqi F, Deak M, Thastrup J, Alessi D, et al. Structural insights into the recognition of substrates and activators by the OSR1 kinase. EMBO Rep. 2007;8:839-45 pubmed
    ..a unique peptide (Arg-Phe-Xaa-Val) motif present in OSR1- and SPAK-activating kinases (with-no-lysine kinase 1 (WNK1) and WNK4) as well as its substrates (NKCC1 and NKCC2)...
  68. Moore T, Garg R, Johnson C, Coptcoat M, Ridley A, Morris J. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. J Biol Chem. 2000;275:4311-22 pubmed
    ..the sterile 20 (STE20) family of serine-threonine kinases which we have called prostate-derived STE20-like kinase (PSK) and characterized functionally...
  69. Vidal Petiot E, Cheval L, Faugeroux J, Malard T, Doucet A, Jeunemaitre X, et al. A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms. PLoS ONE. 2012;7:e37751 pubmed publisher
    ..human diseases, Familial Hyperkalemic Hypertension (FHHt) and Hereditary Sensory and Autonomic Neuropathy type 2 (HSAN2). Alternative promoters give rise to a ubiquitous isoform, L-WNK1, and a kidney-specific isoform, KS-WNK1...
  70. Clark T, Schweitzer A, Chen T, Staples M, Lu G, Wang H, et al. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol. 2007;8:R64 pubmed
    ..In addition, we identified and validated a number of novel exons with tissue-specific splicing patterns. The tissue map data will likely serve as a valuable source of information on the regulation of alternative splicing. ..
  71. Yu G, Cheng M, Wang W, Zhao R, Liu Z. Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure. Biochem Biophys Res Commun. 2017;485:255-260 pubmed publisher
    ..BK) channel and Na-K-2Cl cotransporter (NKCC2) as well as the upstream regulator with-no-lysine kinase 1 (WNK1) enhanced in female mice under normal condition...
  72. Pacheco Cuellar G, González Huerta L, Valdés Miranda J, Peláez González H, Zenteno Bacheron S, Cazarín Barrientos J, et al. Hereditary sensory and autonomic neuropathy II due to novel mutation in the HSN2 gene in Mexican families. J Neurol. 2011;258:1890-2 pubmed publisher
  73. Dbouk H, Weil L, Perera G, Dellinger M, Pearson G, Brekken R, et al. Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proc Natl Acad Sci U S A. 2014;111:15999-6004 pubmed publisher
    ..In mice, global as well as endothelial-specific WNK1 gene disruption results in embryonic lethality due to angiogenic and cardiovascular defects...
  74. Reshak A. Lithium borate Li3B5O8(OH)2 with large second harmonic generation and a high damage threshold in the deep-ultraviolet spectral range. Phys Chem Chem Phys. 2017;19:30703-30714 pubmed publisher
    ..5 times that of the well-known NLO crystal KH2PO4 (KDP) at ? = 1064 nm and 3.5 times that of KDP at ? = 190 nm, which is transparent down to the DUV region...
  75. Disse Nicodeme S, Achard J, Desitter I, Houot A, Fournier A, Corvol P, et al. A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet. 2000;67:302-10 pubmed
    ..In conclusion, we hereby demonstrate further genetic heterogeneity of this Mendelian form of hypertension and identify a new PHA2C locus, the most compelling and precise linkage interval described to date...
  76. Wang L, Fan J, FRANCIS J, Georghiou G, Hergert S, Li S, et al. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res. 2017;27:1300-1311 pubmed publisher
    ..By clearly resolving phylogenic relationships, we uncovered mutated LCP1 and WNK1 as novel CLL drivers, supported by functional evidence demonstrating their impact on CLL pathways...
  77. Sengupta S, Tu S, Wedin K, Earnest S, Stippec S, Luby Phelps K, et al. Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. J Biol Chem. 2012;287:37868-79 pubmed publisher
    ..b>WNK1 affects ion transport in part through activation of the closely related Ste20 family protein kinases oxidative ..