Gene Symbol: WIF1
Description: WNT inhibitory factor 1
Alias: WIF-1, wnt inhibitory factor 1
Species: human
Products:     WIF1

Top Publications

  1. Yang Z, Wang Y, Fang J, Chen F, Liu J, Wu J, et al. Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas. J Exp Clin Cancer Res. 2010;29:26 pubmed publisher
    ..Our results demonstrate that the WIF-1 gene is frequently down-regulated or silenced in astrocytomas by aberrant promoter methylation. This may be an important mechanism in astrocytoma carcinogenesis. ..
  2. Hsieh J, Kodjabachian L, Rebbert M, Rattner A, Smallwood P, Samos C, et al. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999;398:431-6 pubmed
  3. Kansara M, Tsang M, Kodjabachian L, Sims N, Trivett M, Ehrich M, et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest. 2009;119:837-51 pubmed publisher
    ..cell lines in a high-throughput screen for epigenetically silenced tumor suppressor genes and identified Wnt inhibitory factor 1 (WIF1), which encodes an endogenous secreted Wnt pathway antagonist, as a candidate tumor suppressor gene...
  4. Ding Z, Qian Y, Zhu L, Xiong Q. Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol. 2009;15:2595-601 pubmed
    ..The aberrant promoter methylation and decreased expression of DKK-3 and WIF-1 may be an important mechanism in HCC, and may be a far-reaching significance in early diagnosis and therapy of HCC. ..
  5. Veeck J, Wild P, Fuchs T, Schüffler P, Hartmann A, Knüchel R, et al. Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer. 2009;9:217 pubmed publisher
    ..survival in cancer, we aimed at investigating a potential prognostic impact of the two Wnt antagonizing molecules WIF1 and DKK3 in breast cancer, which are frequently silenced by promoter methylation in this disease...
  6. Hu J, Dong A, Fernandez Ruiz V, Shan J, Kawa M, Martinez Ansó E, et al. Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res. 2009;69:6951-9 pubmed publisher
    ..Human Wnt inhibitory factor 1 (WIF1) and secreted frizzled-related protein 1 (sFRP1) were each fused with Fc fragment of human IgG1 to ..
  7. Rubin E, Guo Y, Tu K, Xie J, Zi X, Hoang B. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther. 2010;9:731-41 pubmed publisher
    ..Together, these data suggest that WIF-1 exerts potent antiosteosarcoma effect in vivo in mouse models. Therefore, the reexpression of WIF-1 in WIF-1-deficient osteosarcoma represents a potential novel treatment and preventive strategy. ..
  8. Yee D, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, et al. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer. 2010;9:162 pubmed publisher
    ..We investigated the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, WIF1, on the growth and cellular invasiveness of a bone metastatic PCa cell line, PC3...
  9. Reguart N, He B, Xu Z, You L, Lee A, Mazieres J, et al. Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochem Biophys Res Commun. 2004;323:229-34 pubmed

More Information

Publications109 found, 100 shown here

  1. Lambiv W, Vassallo I, Delorenzi M, Shay T, Diserens A, Misra A, et al. The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. Neuro Oncol. 2011;13:736-47 pubmed publisher
    ..number aberrations in the chromosomal region 12q13 to 12q15 that is flanked by MDM2 and CDK4 identified Wnt inhibitory factor 1 (WIF1) as a candidate tumor suppressor gene in glioblastoma...
  2. Urakami S, Shiina H, Enokida H, Kawakami T, Tokizane T, Ogishima T, et al. Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. Clin Cancer Res. 2006;12:383-91 pubmed
    ..The present study elucidates novel pathways that are involved in the pathogenesis of bladder cancer. ..
  3. Batra S, Shi Y, Kuchenbecker K, He B, Reguart N, Mikami I, et al. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem Biophys Res Commun. 2006;342:1228-32 pubmed
    ..New therapies toward inhibition of the Wnt pathway through WIF-1 might be promising for the future treatment of malignant mesothelioma. ..
  4. Queimado L, Lopes C, Reis A. WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. Genes Chromosomes Cancer. 2007;46:215-25 pubmed
    ..Here we report the identification of the WNT inhibitory factor 1 (WIF1) gene as a novel HMGA2 fusion partner in a salivary gland pleomorphic adenoma...
  5. Delmas A, Riggs B, Pardo C, Dyer L, Darst R, Izumchenko E, et al. WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. Carcinogenesis. 2011;32:1625-33 pubmed publisher
    ..Wnt inhibitory factor-1 (WIF1) is a secreted protein that binds Wnt and antagonizes Wnt activity...
  6. Wu J, Fang J, Yang Z, Chen F, Liu J, Wang Y. Wnt inhibitory factor-1 regulates glioblastoma cell cycle and proliferation. J Clin Neurosci. 2012;19:1428-32 pubmed publisher
    ..1-WIF1 vector to restore WIF-1 expression...
  7. Taniguchi H, Yamamoto H, Hirata T, Miyamoto N, Oki M, Nosho K, et al. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. Oncogene. 2005;24:7946-52 pubmed
    ..Modulation of the Wnt pathway, through reversal of WIF-1 silencing by demethylating agents, is a potential target for treatment and/or prevention of gastrointestinal cancers. ..
  8. Lin Y, You L, Xu Z, He B, Mikami I, Thung E, et al. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun. 2006;341:635-40 pubmed
    ..Our results indicate that aberrant Wnt signaling is a common event in NPC carcinogenesis linked with WIF-1 silencing in at least cell lines. Strategies targeting these molecules should be potentially promising in treating NPC. ..
  9. Elston M, Gill A, Conaglen J, Clarkson A, Shaw J, Law A, et al. Wnt pathway inhibitors are strongly down-regulated in pituitary tumors. Endocrinology. 2008;149:1235-42 pubmed
    ..Reduced tumor expression of Wnt inhibitory factor-1 (WIF1), sFRP2, and sFRP4 mRNA was confirmed by real-time quantitative RT-PCR (P <0.001 and P = 0.002 and 0...
  10. Ramachandran I, Thavathiru E, Ramalingam S, Natarajan G, Mills W, Benbrook D, et al. Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. Oncogene. 2012;31:2725-37 pubmed publisher
    ..Here, we demonstrate that the Wnt inhibitory factor 1 (WIF1), a secreted Wnt antagonist, is downregulated in all human primary cervical tumors and cell lines ..
  11. Trifa F, Karray Chouayekh S, Jmal E, Jmaa Z, Khabir A, Sellami Boudawara T, et al. Loss of WIF-1 and Wnt5a expression is related to aggressiveness of sporadic breast cancer in Tunisian patients. Tumour Biol. 2013;34:1625-33 pubmed publisher
    ..031) and lower still in those showing more aggressive behavior, suggesting that Wnt5a, a ligand involved in the noncanonical Wnt/?-catenin pathway, could act as a tumor suppressor gene in breast cancer. ..
  12. Ohigashi T, Mizuno R, Nakashima J, Marumo K, Murai M. Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Prostate. 2005;62:61-8 pubmed
    ..Our results show that Wnt signaling is involved in Akt activation in Pca cells. Our data also indicate the possibility that Wnt and its signaling pathway can be therapeutic targets for PTEN-mutated advanced Pca. ..
  13. Tang Y, Simoneau A, Liao W, Yi G, Hope C, Liu F, et al. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009;8:458-68 pubmed publisher
    ..The secreted Wnt inhibitory factor-1 (WIF1) has shown consistent growth-inhibitory effect on various cancer cell lines...
  14. Lee B, Lee E, Jung E, Chun H, Chang D, Song S, et al. Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. Clin Cancer Res. 2009;15:6185-91 pubmed publisher
    ..6% and a negative predictive value of 88.8%. The present study suggests that tumor-specific methylation of APC, MGMT, RASSF2A, and Wif-1 genes might be a valuable biomarker in plasma for the early detection of colorectal cancer. ..
  15. Kawakami K, Hirata H, Yamamura S, Kikuno N, Saini S, Majid S, et al. Functional significance of Wnt inhibitory factor-1 gene in kidney cancer. Cancer Res. 2009;69:8603-10 pubmed publisher
    ..In conclusion, this is the first report documenting that the WIF-1 is downregulated by promoter methylation and functions as a tumor suppressor gene by inducing apoptosis in RCC cells. ..
  16. George L, Mitra A, Thimraj T, Irmler M, Vishweswaraiah S, Lunding L, et al. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017;18:152 pubmed publisher
    ..Noteworthy genes selected as candidates for their consistent expression include: Wnt inhibitor factor 1 (Wif1), follistatin (Fst), chitinase-like 1 (Chil1), and Chil3...
  17. Gamat M, Malinowski R, Parkhurst L, Steinke L, Marker P. Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate. PLoS ONE. 2015;10:e0139522 pubmed publisher
    ..Other genes implicated in prostatic development including Sox9, Wif1 and Srd5a2 were unaffected by DFMO...
  18. Valdez B, Li Y, Murray D, Ji J, Liu Y, Popat U, et al. Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators. Exp Hematol. 2015;43:448-61.e2 pubmed publisher
    ..of Clad and Clo may complement DAC activity; increase demethylation of the gene promoters for SFRP1, DKK3, and WIF1; and cause degradation of β-catenin in cells exposed to Clad/Clo+Flu+Bu+DAC+Pano...
  19. Mirmalek Sani S, Stokes P, Tare R, Ralph E, Inglis S, Hanley N, et al. Derivation of a novel undifferentiated human foetal phenotype in serum-free cultures with BMP-2. J Cell Mol Med. 2009;13:3541-55 pubmed publisher
    ..altered expression of metabolic genes (GFPT2, SC4MOL and SQLE), genes involved in morphogenesis (SOX15 and WIF1) and differentiation potential (C1orf19, CHSY-2,DUSP6, HMGCS1 and PPL)...
  20. Pettinato G, Ramanathan R, Fisher R, Mangino M, Zhang N, Wen X. Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/?-catenin Pathway Inhibition. Sci Rep. 2016;6:32888 pubmed publisher
  21. Lui K, Zhao H, Qiu C, Li C, Zhang Z, Peng H, et al. Integrator complex subunit 6 (INTS6) inhibits hepatocellular carcinoma growth by Wnt pathway and serve as a prognostic marker. BMC Cancer. 2017;17:644 pubmed publisher
    ..This newly identified INTS6/WIF-1 axis indicates the molecular mechanism of HCC and may represent a therapeutic target in HCC patients. ..
  22. Ustiyan V, Bolte C, Zhang Y, Han L, Xu Y, Yutzey K, et al. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol. 2018;443:50-63 pubmed publisher
    ..FOXF1 decreased expression of the Wnt inhibitor Wif1 through direct transcriptional repression...
  23. Joshi H, Vastrad B, Vastrad C. Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas. J Mol Neurosci. 2019;: pubmed publisher
    ..Subsequently, ESR1, SOX2, TTN, GFAP, WIF1, TTR, XIST, SPAG5, PPBP, AR, IL1R2, and HIST1H1C were diagnosed as the top hub genes in the upregulated and ..
  24. Zhu Y, Zhuo J, Li C, Wang Q, Liu X, Ye L. Regulatory network analysis of hypertension and hypotension microarray data from mouse model. Clin Exp Hypertens. 2018;40:631-636 pubmed publisher
    ..among the top 10 differentially regulated BPL-related DEGs, no common differentially regulated DEGs were found, Wif1, Urb2, and Gtf2ird1 were found among the top ten DEGs in the three tissues other than the kidney tissue...
  25. Lim F, Ogawa S, Smith A, Parhar I. Proteomics Identification of Potential Candidates Involved in Cell Proliferation for Early Stage of Brain Regeneration in the Adult Zebrafish. Zebrafish. 2017;14:10-22 pubmed publisher
    ..processes involved in the early stages of neuroregeneration in zebrafish CNS: apoptosis regulation (Wnt inhibitory factor 1 [WIF1]), neuroprotection (metallothionein), cell proliferation (Spred2, ependymin, Lhx1, and Wnts), ..
  26. Cardoso M, Castelletti C, Lima Filho J, Martins D, Teixeira J. Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. Mutat Res. 2017;773:161-173 pubmed publisher
    ..Other ten genes (CDH13, FHIT, PTEN, MLH1, TP73, CDKN1A, CACNA2D2, TERT, WIF1, APC) seemed to play a role in cervical cancer, but the lack of studies prevented their inclusion as possible ..
  27. Rice L, Ziemek J, Stratton E, McLaughlin S, Padilla C, Mathes A, et al. A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheumatol. 2015;67:3004-15 pubmed publisher
    ..of genes, including additional genes that changed statistically significantly over time: CTGF, CD163, CCL2, and WIF1. In an independent validation data set, biomarker levels calculated using both models correlated highly with the ..
  28. Fischetto R, Palumbo O, Ortolani F, Palumbo P, Leone M, Causio F, et al. Clinical and molecular characterization of a second family with the 12q14 microdeletion syndrome and review of the literature. Am J Med Genet A. 2017;173:1922-1930 pubmed publisher
    ..In addition, we suggest the XPOT, TBK1, WIF1 genes as candidates for the clinical features observed in our patients and discuss for the first time the possible ..
  29. Mitani S, Takayama K, Nagamoto Y, Imagawa K, Sakurai F, Tachibana M, et al. Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling. Mol Ther. 2017;25:1420-1433 pubmed publisher
    ..Therefore, WNT signal modulators secreted from hepatocytes or cholangiocytes conferred zone-specific hepatic properties onto HLCs. ..
  30. Ji T, Guo Y, Kim K, McQueen P, Ghaffar S, Christ A, et al. Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Mol Cancer. 2015;14:86 pubmed publisher
    ..Inhibition of Wnt signaling by overexpression of secreted Wnt antagonists soluble LRP5, Frzb, and WIF1 markedly down-regulated mRNA and protein expression of NRP2 in osteosarcoma cell lines...
  31. Matsunaga E, Nambu S, Oka M, Tanaka M, Taoka M, Iriki A. Identification of tool use acquisition-associated genes in the primate neocortex. Dev Growth Differ. 2015;57:484-95 pubmed publisher
    ..chain reaction and histochemical analysis, we confirmed at least three genes (ADAM19, SPON2, and WIF1) with statistically different expression levels in neurons and glial cells...
  32. Barreto S, González Vázquez A, R Cameron A, O Brien F, Murray D. Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis. Sci Rep. 2017;7:11494 pubmed publisher
    ..matrix (MMP9), mediating the activation of inflammation (IL1β) and controlling osteogenic differentiation (WIF1, BMP6, NOX1) in cells from fused sutures...
  33. Zhou X, Chen J, Tang W. The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance. Acta Biochim Biophys Sin (Shanghai). 2014;46:1011-5 pubmed publisher
    ..We tried to elucidate the molecular mechanisms of HOTAIR in the aspects of tumorigenesis, metastasis, drug resistance, and regulation. ..
  34. Liu J, Lam J, Chow K, Xu A, Lam K, Moon R, et al. Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1. Carcinogenesis. 2008;29:2195-202 pubmed publisher
    ..we extended our studies to elucidate the effects of ADN on regulating the expressions of Wnt inhibitory factor-1 (WIF1), a Wnt antagonist frequently silenced in human breast tumors...
  35. Kwon H, Lee H, Ji Y, Rubin J, Tomarev S. Myocilin is a modulator of Wnt signaling. Mol Cell Biol. 2009;29:2139-54 pubmed publisher
    ..Myocilin and Wnt proteins may perform redundant functions in the mammalian eye, since myocilin modulates Wnt signaling by interacting with components of this signaling pathway. ..
  36. Bis J, DeCarli C, Smith A, van der Lijn F, Crivello F, Fornage M, et al. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012;44:545-51 pubmed publisher
    ..0 × 10(-7). In two additional samples (n = 2,318), associations were replicated at 12q14 within MSRB3-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10(-11)) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2...
  37. Wang R, Geng N, Zhou Y, Zhang D, Li L, Li J, et al. Aberrant Wnt-1/beta-catenin signaling and WIF-1 deficiency are important events which promote tumor cell invasion and metastasis in salivary gland adenoid cystic carcinoma. Biomed Mater Eng. 2015;26 Suppl 1:S2145-53 pubmed publisher
    ..Dislocation of E-cadherin in sAdCC was observed. These results suggest that sAdCC exhibits diverse expressions of Wnt components. It has an important relationship with the invasive phenotype of these cells. ..
  38. Skaria T, Burgener J, Bächli E, Schoedon G. IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling. PLoS ONE. 2016;11:e0156002 pubmed publisher
    ..Stress fiber formation was notably decreased in the presence of Wnt inhibitory factor 1 (WIF1)...
  39. Garrigou S, Perkins G, Garlan F, Normand C, Didelot A, Le Corre D, et al. A Study of Hypermethylated Circulating Tumor DNA as a Universal Colorectal Cancer Biomarker. Clin Chem. 2016;62:1129-39 pubmed publisher
    ..Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, ..
  40. Garlan F, Laurent Puig P, Sefrioui D, Siauve N, Didelot A, Sarafan Vasseur N, et al. Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study). Clin Cancer Res. 2017;23:5416-5425 pubmed publisher
    ..PCR assays based either on detection of gene mutation (KRAS, BRAF, TP53) or hypermethylation (WIF1, NPY). CT scans were centrally assessed using RECIST v1.1 criteria...
  41. Urakami S, Shiina H, Enokida H, Kawakami T, Kawamoto K, Hirata H, et al. Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin Cancer Res. 2006;12:2109-16 pubmed
    ..This is the first report demonstrating that M score analysis of Wnt-antagonist genes could serve as an excellent epigenetic biomarker panel for bladder tumors. ..
  42. Chan S, Cui Y, Van Hasselt A, Li H, Srivastava G, Jin H, et al. The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Lab Invest. 2007;87:644-50 pubmed
    ..However, the molecular mechanism leading to this abnormality is still obscure. Wnt inhibitory factor-1 (WIF1) is a secreted antagonist of the Wnt pathway, and is recently shown to be inactivated by epigenetic mechanism in ..
  43. Morimoto E, Li M, Khalid A, Krum S, Chimge N, Frenkel B. Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation. J Cell Physiol. 2017;232:145-53 pubmed publisher
    ..Among the genes synergistically stimulated by GCs and Runx2 was Wnt inhibitory Factor 1 (Wif1), and Wif1 protein was readily detectable in medium conditioned by cultures co-treated with dox and ..
  44. Skaria T, Bächli E, Schoedon G. Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells. Cell Adh Migr. 2017;11:24-38 pubmed publisher
    ..The antagonist Wnt inhibitory factor 1 (WIF1) that specifically interferes with the WIF domain of Ryk receptors prevented actin polymerization...
  45. Goldstein N, Koster M, Hoaglin L, Wright M, Robinson S, Robinson W, et al. Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection. Exp Dermatol. 2016;25:805-11 pubmed publisher
    ..of melanocyte-specific genes and significantly higher expression of three melanocytic stem cell genes (SOX9, WIF1 and SFRP1), while ALCAM and ALDH1A1 transcripts did not show significant variation...
  46. Liang J, Zhou H, Peng Y, Xie X, Li R, Liu Y, et al. ?-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer. Biomed Res Int. 2016;2016:4923903 pubmed
    ..between the cancer clinicopathological characteristics and the key molecules such as ?-catenin and Wnt inhibitory factor 1 (WIF1)...
  47. Deb S, Gorringe K, Pang J, Byrne D, Takano E, Investigators K, et al. BRCA2 carriers with male breast cancer show elevated tumour methylation. BMC Cancer. 2017;17:641 pubmed publisher
    ..promoter methylation by methylation-sensitive high resolution melting in a panel of 10 genes (RASSF1A, TWIST1, APC, WIF1, MAL, RAR?, CDH1, RUNX3, FOXC1 and GSTP1)...
  48. Maeda T, Guan J, Koyanagi M, Makino N. Altered expression of genes associated with telomere maintenance and cell function of human vascular endothelial cell at elevated temperature. Mol Cell Biochem. 2014;397:305-12 pubmed publisher
  49. Bleil J, Sieper J, Maier R, Schlichting U, Hempfing A, Syrbe U, et al. Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS. Arthritis Res Ther. 2015;17:170 pubmed publisher
    ..In contrast, the reduced expression of Sox9, BMP-2 and BMP-7 concomitantly with induced COL2 expression rather point to disturbed cartilage homeostasis promoting cartilage degeneration in AS. ..
  50. Huang K, Mikeska T, Li J, Takano E, Millar E, Graham P, et al. Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour. BMC Cancer. 2015;15:669 pubmed publisher
    ..screen promoter methylation in a panel of 13 genes reported as methylated in breast cancer (RASSF1A, TWIST1, APC, WIF1, MGMT, MAL, CDH13, RARβ, BRCA1, CDH1, CDKN2A, TP73, and GSTP1) in 29 tumour pairs (16 ipsilateral and 13 ..
  51. van Beuge M, Ten Dam E, Werker P, Bank R. Wnt pathway in Dupuytren disease: connecting profibrotic signals. Transl Res. 2015;166:762-771.e3 pubmed publisher
    ..the strongest downregulated genes in this study were 4 antagonists of Wnt signaling (DKK1, FRZB, SFRP1, and WIF1)...
  52. Afgar A, Fard Esfahani P, Mehrtash A, Azadmanesh K, Khodarahmi F, Ghadir M, et al. MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition. Cancer Biol Ther. 2016;17:1126-1138 pubmed
    ..Expression of these genes such as SFRP1 (2 and 1.6-fold), SFRP2 (0.07 and 4-fold), WIF1 (0...
  53. Schmid S, Sathe A, Guerth F, Seitz A, Heck M, Maurer T, et al. Wntless promotes bladder cancer growth and acts synergistically as a molecular target in combination with cisplatin. Urol Oncol. 2017;35:544.e1-544.e10 pubmed publisher
    ..Expression level of ?-catenin, WIF1, Dickkopf proteins (DKK), HSulf-2, sFRP4, and WLS was modulated by transfecting or infecting cells transiently or ..
  54. Yoshino M, Suzuki M, Tian L, Moriya Y, Hoshino H, Okamoto T, et al. Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers. Int J Oncol. 2009;35:1201-9 pubmed
    ..036; Wif-1, P=0.035). In conclusion, the hypermethylation of the p16 and Wif-1 genes has potential as biomarkers that may be used to predict the prognosis of stage IA NSCLC. ..
  55. Surmann Schmitt C, Sasaki T, Hattori T, Eitzinger N, Schett G, von der Mark K, et al. The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity. J Cell Physiol. 2012;227:2207-16 pubmed publisher
    b>Wnt inhibitory factor 1 (Wif-1) is a secreted antagonist of Wnt signalling. We recently demonstrated that this molecule is expressed predominantly in superficial layers of epiphyseal cartilage but also in bone and tendon...
  56. Ge X, Ma H, Zheng X, Ruan H, Liao X, Xue W, et al. HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci. 2013;104:1675-82 pubmed publisher
    ..This newly identified HOTAIR/WIF-1 axis clarified the molecular mechanism of ESCC cell metastasis and represented a novel therapeutic target in patients with ESCC. ..
  57. Koyama N, Hakura A, Toritsuka N, Sonoda J, Seki Y, Tohyama O, et al. Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium. Chem Biol Interact. 2015;240:164-70 pubmed publisher
    ..part (site of predilection for tumor induction) of the colonic mucosae, especially in colonic tumors: WNT inhibitory factor 1 (Wif1; 14.6-fold increase) and interferon induced membrane protein 3 (Ifitm3; 5.7-fold increase)...
  58. Chen J, Shen Z, Zheng Y, Wang S, Mao W. Radiotherapy induced Lewis lung cancer cell apoptosis via inactivating β-catenin mediated by upregulated HOTAIR. Int J Clin Exp Pathol. 2015;8:7878-86 pubmed
    ..Radiotherapy induced Lewis lung cancer cell apoptosis via inactivating β-catenin mediated by upregulated HOTAIR. ..
  59. Song G, Cao H, Yao S, Li C. Abnormal expression of WIF1 in hepatocellular carcinoma cells and its regulating effect on invasion and metastasis factors of TIMP-3 and caveolin-1 of hepatocellular carcinoma. Asian Pac J Trop Med. 2015;8:958-963 pubmed publisher
    To discuss the abnormal expression of Wnt inhibitory factor (WIF1) in hepatocellular carcinoma cells and its regulating effect on the hepatocellular carcinoma invasion and metastasis factors of tissue inhibitor of matrix ..
  60. Liu H, Luo K, Luo D. Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2018;8:2759 pubmed publisher
    ..Here, we conducted analysis to identify age-independent, AD-specific genes. We found that the MET, WIF1, and NPTX2 genes are downregulated in AD...
  61. Chmelařová M, Dvorakova E, Spacek J, Laco J, Mžik M, Palicka V. Promoter methylation of GATA4, WIF1, NTRK1 and other selected tumour suppressor genes in ovarian cancer. Folia Biol (Praha). 2013;59:87-92 pubmed
    ..Using a 20% cut-off for methylation, we observed significantly higher methylation in genes NTKR1, GATA4 and WIF1 in the ovarian cancer group compared with the control group...
  62. Zhu H, He J, Ye L, Lin F, Hou J, Zhong Y, et al. Mechanisms of angiogenesis in a Curculigoside A-treated rat model of cerebral ischemia and reperfusion injury. Toxicol Appl Pharmacol. 2015;288:313-21 pubmed publisher
  63. Ko Y, Jamaluddin M, Adebayo M, Bajwa P, Scott R, Dharmarajan A, et al. Extracellular matrix (ECM) activates β-catenin signaling in uterine fibroids. Reproduction. 2018;155:61-71 pubmed publisher
    ..i>WIF1, a WNT inhibitor, was identified as the most significantly upregulated gene in fibroids...
  64. Xu M, Yang Y, Geng Y, Li J, Ma Y, Zhang F, et al. [Methylation Status and mRNA Expression of DKK-3 and WIF-1 in Acute Myeloid Leukemia Patients]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1314-1320 pubmed publisher
    ..520, P=0.029). Wnt/?-catenin signaling pathway is abnormally activated in AML patients, the DKK-3 and WIF-1 gene promoter methylation may be involved in Wnt pathways activation and the pathogenesis of AML. ..
  65. Simon M, Grandage V, Linch D, Khwaja A. Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. Oncogene. 2005;24:2410-20 pubmed
    ..These results provide evidence for the involvement of the Wnt/beta-catenin pathway in the pathogenesis of AML. ..
  66. Alvarez C, Tapia T, Cornejo V, Fernández W, Muñoz A, Camus M, et al. Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer. Mol Carcinog. 2013;52:475-87 pubmed publisher
    ..are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a previous array-CGH analysis from our group showed that these genes are found in deleted genomic ..
  67. Askevold E, Gullestad L, Aakhus S, Ranheim T, Tønnessen T, Solberg O, et al. Secreted Wnt modulators in symptomatic aortic stenosis. J Am Heart Assoc. 2012;1:e002261 pubmed publisher
  68. Zheng Y, Li X, Jiang Y, Xu Y, Song B, Zhou Q, et al. Promoter hypermethylation of Wnt inhibitory factor-1 in patients with lung cancer: A systematic meta-analysis. Medicine (Baltimore). 2016;95:e5433 pubmed
    ..More investigations, including a larger number of subjects, are required to further confirm the findings of our analysis. ..
  69. Zhang H, Hu B, Wang Z, Zhang F, Wei H, Li L. miR-181c contributes to cisplatin resistance in non-small cell lung cancer cells by targeting Wnt inhibition factor 1. Cancer Chemother Pharmacol. 2017;80:973-984 pubmed publisher
    ..miR-181c was upregulated in NSCLC tissues, and parental and DDP-resistant NSCLC cells. miR-181c downregulation or WIF1 overexpression increased DDP sensitivity of DDP-resistant NSCLC cells by decreasing survival rate and promoting DDP-..
  70. A P S, Laishram R. Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion. Mol Cell Biol. 2018;38: pubmed publisher
    ..encoding key anti-invasive factors (KISS1R, CDH1, NME1, CDH13, FEZ1, and WIF1) in breast cancer...
  71. Gao Z, Xu Z, Hung M, Lin Y, Wang T, Gong M, et al. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Res. 2009;29:2025-30 pubmed
    ..EGCG also decreased cytosolic beta-catenin protein level and inhibited Tcf/Lef reporter activity. These results suggest the potential therapeutic use of EGCG for the reversal of WIF-1 promoter methylation. ..
  72. Gudjonsson J, Johnston A, Stoll S, Riblett M, Xing X, Kochkodan J, et al. Evidence for altered Wnt signaling in psoriatic skin. J Invest Dermatol. 2010;130:1849-59 pubmed publisher
    ..In contrast, expression of WIF1 mRNA, encoding a secreted antagonist of the Wnt proteins, was downregulated >10-fold in lesional skin, along ..
  73. Fendri A, Khabir A, Hadri Guiga B, Sellami Boudawara T, Daoud J, Frikha M, et al. Epigenetic alteration of the Wnt inhibitory factor-1 promoter is common and occurs in advanced stage of Tunisian nasopharyngeal carcinoma. Cancer Invest. 2010;28:896-903 pubmed publisher
    ..003) and the age (p = .014). The Wnt-5a mRNA was higher in tumors and correlated with TNM (p = .012). The methylation of WIF-1 contributes to the activation of the Wnt pathway in NPC. ..
  74. Schlüter H, Stark H, Sinha D, Boukamp P, Kaur P. WIF1 is expressed by stem cells of the human interfollicular epidermis and acts to suppress keratinocyte proliferation. J Invest Dermatol. 2013;133:1669-73 pubmed publisher
  75. Lee S, Park J, Kim D. Wif1 hypermethylation as unfavorable prognosis of non-small cell lung cancers with EGFR mutation. Mol Cells. 2013;36:69-73 pubmed publisher
    ..Promoter hypermethylation of Wnt inhibitory factor 1 (Wif1) has become a common event in a number of human tumors...
  76. Ramachandran I, Ganapathy V, Gillies E, Fonseca I, Sureban S, Houchen C, et al. Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence. Cell Death Dis. 2014;5:e1246 pubmed publisher
    ..Here we report for the first time that downregulation of the Wnt inhibitory factor 1 (WIF1) is a widespread event in salivary gland carcinoma ex-pleomorphic adenoma (CaExPA)...
  77. Guo H, Zhou S, Tan L, Wu X, Wu Z, Ran R. Clinicopathological significance of WIF1 hypermethylation in NSCLC, a meta-analysis and literature review. Oncotarget. 2017;8:2550-2557 pubmed publisher
    ..WIF-1 hypermethylation is predominant in squamous cell carcinoma (SCC), suggesting that WIF-1methylation contributes to the development of NSCLC, especially SCC. ..
  78. Yang S, Li S, Dong Z, Kan Q. Epigenetic inactivation of Wnt inhibitory factor-1 in human esophageal squamous cell carcinoma. Oncol Res. 2012;20:123-30 pubmed
    Wnt inhibitory factor-1 (WIF1), as one of most important Wnt antagonists, has been detected frequently silenced by promoter hypermethylation in various types of cancer...
  79. Mao X, Xiao J, Xu G, Li Z, Wu H, Li Y, et al. CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/?-catenin signaling pathway. Oncotarget. 2017;8:77241-77253 pubmed publisher
    ..BC 5637 cells were transfected with control, siRNA scramble control (siRNA-NC), si-CUL4B, and CUL4B or Wnt inhibitory factor 1 (WIF-1) overexpression constructs...
  80. Zhou M, Wu J, Yu Y, Yang Y, Li J, Cui L, et al. Polygonum multiflorm alleviates glucocorticoid?induced osteoporosis and Wnt signaling pathway. Mol Med Rep. 2017;: pubmed publisher
    ..The left femur was used to analyze the protein expression of dickkopf?1 (DKK1), WNT inhibitory factor 1 (WIF1) and secreted frizzled related protein 4 using western blotting...
  81. Liepinsh E, Banyai L, Patthy L, Otting G. NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. J Mol Biol. 2006;357:942-50 pubmed
    ..The results point to a possible role of WIF domains as a recognition motif of Wnt and Drosophila Hedgehog proteins that are activated by palmitoylation. ..
  82. Clement G, Guilleret I, He B, Yagui Beltran A, Lin Y, You L, et al. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus. Cancer Sci. 2008;99:46-53 pubmed
    ..Restoring functional WIF-1 might be used as a new targeted therapy for the treatment of this malignancy. ..
  83. Gao Z, Xu Z, Hung M, Lin Y, Wang T, Gong M, et al. Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells. Oncol Rep. 2009;22:1479-84 pubmed
    ..These results further suggest that procaine and procainamide may have a potential use for preventing the development of lung cancer...
  84. Park T, Kim M, Kim H, Park S, Park K, Ortonne J, et al. Wnt inhibitory factor (WIF)-1 promotes melanogenesis in normal human melanocytes. Pigment Cell Melanoma Res. 2014;27:72-81 pubmed publisher
    ..These findings suggest that melanocytes express WIF-1 constitutively in vivo and in vitro and that WIF-1 promotes melanogenesis in normal human melanocytes. ..
  85. Guo M, Zhang X, Wang G, Sun J, Jiang Z, Khadarian K, et al. miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1. Cancer Lett. 2015;360:76-86 pubmed publisher
    ..Conversely, inhibition of miR-603 remarkably reduced these effects. We confirmed that WIF1 and CTNNBIP1 are bona fide targets of miR-603...
  86. Chim C, Fung T, Liang R. Methylation of cyclin-dependent kinase inhibitors, XAF1, JUNB, CDH13 and soluble Wnt inhibitors in essential thrombocythaemia. J Clin Pathol. 2010;63:518-21 pubmed publisher
    ..studied the methylation status of CDKN2A, CDKN2B, XAF1, CDH13, JUNB and a panel of soluble Wnt inhibitors including WIF1, DKK3, APC, SFRP1, SFRP2, SFRP4 and SFRP5 by methylation-specific PCR in 31 bone marrow and 21 peripheral blood ..
  87. Sanchez Hernandez D, Sierra J, Ortigão Farias J, Guerrero I. The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog. Development. 2012;139:3849-58 pubmed
    ..Here, we investigate which parts of the Shf and human Wif-1 (WIF1) proteins are responsible for functional divergence...
  88. Roperch J, Incitti R, Forbin S, Bard F, Mansour H, Mesli F, et al. Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer. BMC Cancer. 2013;13:566 pubmed publisher
    ..g, 89%/25%, 43%/80% and 28%/91%. We showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers ..
  89. Zhang J, Zhou B, Liu Y, Chen K, Bao P, Wang Y, et al. Wnt inhibitory factor-1 functions as a tumor suppressor through modulating Wnt/?-catenin signaling in neuroblastoma. Cancer Lett. 2014;348:12-9 pubmed publisher
    ..These results provide support that WIF-1 is downregulated and functions as a tumor suppressor by antagonizing Wnt/?-catenin signaling in neuroblastoma, suggesting a potential role as a therapeutic target in neuroblastoma. ..
  90. Gao J, Zhao J, Tan Y. [Expression of Wif-1 and ?-catenin in the Wnt pathway in childhood acute lympho-blastic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:835-839 pubmed
    ..05). Reduced expression of Wif-1 and increased expression of ?-catenin may be involved in the pathogenesis of childhood ALL, and the degree of reduction in Wif-1 and/or increase in ?-catenin may be related to prognosis. ..
  91. Zhao Z, Liu W, Liu J, Wang J, Luo B. The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer. J Med Virol. 2017;89:1844-1851 pubmed publisher
    ..This study aimed to detect the effect of EBV on Wnt inhibitory factor 1 (WIF1), Nemo-like kinase (NLK), and adenomatous polyposis coli (APC) gene methylation, and expression in ..
  92. Coussens A, Hughes I, Wilkinson C, Morris C, Anderson P, Powell B, et al. Identification of genes differentially expressed by prematurely fused human sutures using a novel in vivo - in vitro approach. Differentiation. 2008;76:531-45 pubmed
    ..A large number of differentially expressed genes were identified, including novel genes WIF1, LEF1, SATB2, RARRES1, DEFA1, DMP1, PTPRZ1, and PTPRC, as well as those commonly associated with human suture ..