WDR77

Summary

Gene Symbol: WDR77
Description: WD repeat domain 77
Alias: MEP-50, MEP50, Nbla10071, RP11-552M11.3, p44, p44/Mep50, WD repeat-containing protein 77, androgen receptor cofactor p44, methylosome protein 50
Species: human

Top Publications

  1. ncbi Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer
    Yi Peng
    Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
    Proc Natl Acad Sci U S A 105:5236-41. 2008
  2. ncbi The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity
    Khalid Ouararhni
    Laboratoire Epigénétique et Cancer, Centre National de la Recherche Scientifique FRE 2944, 94801 Villejuif, France
    Genes Dev 20:3324-36. 2006
  3. ncbi Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription
    Keiko Hosohata
    Department of Cancer Biology, M D Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA
    Mol Cell Biol 23:7019-29. 2003
  4. ncbi Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells
    Liran Zhou
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard 173, Houston, Texas 77030, USA
    J Mol Endocrinol 37:283-300. 2006
  5. ncbi CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex
    Jeong Heon Lee
    Herman B Wells Center for Pediatric Research, Section of Pediatric Hematology Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:41725-31. 2005
  6. ncbi APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
  7. ncbi A novel WD repeat protein component of the methylosome binds Sm proteins
    Westley J Friesen
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 277:8243-7. 2002
  8. ncbi The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors
    John J Liang
    Department of Pathology, New York University School of Medicine, NY, USA
    J Urol 177:1918-22. 2007
  9. ncbi Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
    N Fernandez
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA
    Endocrinology 141:146-52. 2000
  10. ncbi Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species
    Toshiyuki Masuzawa
    Laboratory of Microbiology and Immunology, Faculty of Pharmacy, Chiba Institute of Science CIS, Choshi 288 0025, Japan
    J Med Microbiol 57:986-91. 2008

Research Grants

  1. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
  2. ETHANOL AND MAP KINASE CASCADE
    SHIVENDRA SHUKLA; Fiscal Year: 2003
  3. Dual Proteasome and MAPK Inhibition in Cancer Therapy
    Robert Orlowski; Fiscal Year: 2007
  4. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
  5. NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
    DAVID KAETZEL; Fiscal Year: 2003
  6. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
  7. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
  8. MECHANISMS OF THROMBIN INDUCED TOLERANCE TO BRAIN INJURY
    Guohua Xi; Fiscal Year: 2002
  9. METABOLIC REGULATION OF APOLIPOPROTEIN B MRNA EDITING
    Harold Smith; Fiscal Year: 1999
  10. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009

Detail Information

Publications128 found, 100 shown here

  1. ncbi Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer
    Yi Peng
    Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
    Proc Natl Acad Sci U S A 105:5236-41. 2008
    ..We recently identified p44/MEP50 as an AR coactivator and further showed that it is expressed primarily in the nucleus and cytoplasm of benign ..
  2. ncbi The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity
    Khalid Ouararhni
    Laboratoire Epigénétique et Cancer, Centre National de la Recherche Scientifique FRE 2944, 94801 Villejuif, France
    Genes Dev 20:3324-36. 2006
    ..mH2A1.1 recruits PARP-1 to the promoter, thereby inactivating it. Upon heat shock, the Hsp70.1 promoter-bound PARP-1 is released to activate transcription through ADP-ribosylation of other Hsp70.1 promoter-bound proteins...
  3. ncbi Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription
    Keiko Hosohata
    Department of Cancer Biology, M D Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA
    Mol Cell Biol 23:7019-29. 2003
    ..AR transcriptional activity, we used an immunoprecipitation method and identified a 44-kDa protein, designated p44, as a new AR-interacting protein...
  4. ncbi Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells
    Liran Zhou
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard 173, Houston, Texas 77030, USA
    J Mol Endocrinol 37:283-300. 2006
    ..Here, we found that AR cofactor (p44) translocation from the nucleus to the cytoplasm in prostate epithelial cells (ECs) is associated with prostate ..
  5. ncbi CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex
    Jeong Heon Lee
    Herman B Wells Center for Pediatric Research, Section of Pediatric Hematology Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:41725-31. 2005
    ....
  6. ncbi APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
    ..Our data demonstrate that APE1 affects cell growth by directly acting on RNA quality control mechanisms, thus affecting gene expression through posttranscriptional mechanisms...
  7. ncbi A novel WD repeat protein component of the methylosome binds Sm proteins
    Westley J Friesen
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 277:8243-7. 2002
    ..Here, we describe a novel component of the methylosome, a 50-kilodalton WD repeat protein termed methylosome protein 50 (MEP50)...
  8. ncbi The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors
    John J Liang
    Department of Pathology, New York University School of Medicine, NY, USA
    J Urol 177:1918-22. 2007
    The role of androgen receptor coactivators in testicular development and cancer formation is unclear. p44/Mep50 was identified as an androgen receptor coactivator that functions in a complex with protein arginine methyltransferase 5...
  9. ncbi Atypical protein kinase C-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells
    N Fernandez
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA
    Endocrinology 141:146-52. 2000
    ..Cells overexpressing PKCzeta show higher levels of phosphorylated p42/p44 MAPK compared with vector-transfected cells...
  10. ncbi Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species
    Toshiyuki Masuzawa
    Laboratory of Microbiology and Immunology, Faculty of Pharmacy, Chiba Institute of Science CIS, Choshi 288 0025, Japan
    J Med Microbiol 57:986-91. 2008
    ..In this study, p44/msp2 paralogues specific to A. phagocytophilum and 5S-23S rRNA gene-intergenic spacers specific to B...
  11. ncbi Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts
    Shinji Takai
    Department of Pharmacy, Gifu University Graduate School of Medicine, and Department of Clinical Laboratory, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
    J Bone Miner Res 22:337-46. 2007
    ..In this study, we show that p70 S6 kinase activated by FGF-2 negatively regulates VEGF release through SAPK/JNK in osteoblasts...
  12. ncbi [Mechanism of regulation of hepatoma cell cycle by XPD/P44 subcomplex : an in vitro experiment]
    Hong Yun Wang
    Department of Gastroenterology, Second Affiliated Hospital of Nanchang University, Jiangxi Provincial Laboratory of Molecular Medicine, Nanchang University, Nanchang 330006, China
    Zhonghua Yi Xue Za Zhi 88:1997-2001. 2008
    To explore the effects of xeroderma pigmentosum group D(XPD)/P44 subcomplex on the cell cycle of the hepatoma cells.
  13. ncbi Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, 304 Hospital, Burns Institute, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 9:1312-7. 2003
    ....
  14. ncbi Gene transcription profile of the detached retina (An AOS Thesis)
    David N Zacks
    Kellogg Eye Center, University of Michigan, Ann Arbor
    Trans Am Ophthalmol Soc 107:343-82. 2009
    ..We also define the early activation of kinases that might be responsible for the detachment-induced changes in gene transcription...
  15. ncbi Comitogenic effect of catecholamines on rat cardiac fibroblasts in culture
    M Leicht
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 48:274-84. 2000
    ..We studied the ability of norepinephrine and of other catecholamines to affect the proliferation of cardiac fibroblasts isolated from adult rat hearts. Furthermore, we investigated the possible adrenergic receptor involved in this process...
  16. ncbi Characterization of p44/msp2 multigene family of Anaplasma phagocytophilum from two different tick species, Ixodes persulcatus and Ixodes ovatus, in Japan
    - Wuritu
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Jpn J Infect Dis 62:142-5. 2009
    ..This bacterium expresses a variety of 44-kDa immunodominant proteins encoded by the p44/msp2 multigene family on the surface for the purpose of avoiding the host immune defense due to the antigenic ..
  17. ncbi Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes
    J L DeGraff
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:11253-9. 1999
    ..in the trafficking of human alpha2-adrenergic receptors (alpha2-ARs) and the effect of receptor trafficking on p42/p44 MAP kinase activation...
  18. ncbi Anaplasma phagocytophilum has a functional msp2 gene that is distinct from p44
    Quan Lin
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    Infect Immun 72:3883-9. 2004
    The msp2 and p44 genes encode polymorphic major outer membrane proteins that are considered unique to the intraerythrocytic agent of Anaplasma marginale and the intragranulocytic agent of Anaplasma phagocytophilum, respectively...
  19. ncbi Anaplasma phagocytophilum MSP2(P44)-18 predominates and is modified into multiple isoforms in human myeloid cells
    Madhubanti Sarkar
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40504, USA
    Infect Immun 76:2090-8. 2008
    Anaplasma phagocytophilum is the etiologic agent of human granulocytic anaplasmosis. MSP2(P44), the bacterium's major surface protein, is encoded by a paralogous gene family and has been implicated in a variety of pathobiological ..
  20. ncbi Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells
    G Thomas
    Department of Biochemistry, University of Dundee, Scotland
    Eur J Biochem 247:1180-9. 1997
    ..Stimulation of bovine adrenal chromaffin cells with acetylcholine activated SAPK2 and MAPKAP-K2, as well as p42/p44 MAP kinases and their downstream target MAPKAP-K1...
  21. ncbi Identification of novel surface proteins of Anaplasma phagocytophilum by affinity purification and proteomics
    Yan Ge
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210, USA
    J Bacteriol 189:7819-28. 2007
    ..phagocytophilum plays a crucial role in subverting the hostile host cell environment. However, except for the P44/Msp2 outer membrane protein family, the surface components of A. phagocytophilum are largely unknown...
  22. ncbi 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase
    Z Schwartz
    Department of Orthopedics, University of Texas Health Science Center, San Antonio 78229, USA
    Endocrinology 143:2775-86. 2002
    ..In both cells the effect was due to ERK1/2 activation (p42 > p44 in GC; p42 = p44 in RC). MAPK activation was dependent on PKC, but not protein kinase A...
  23. ncbi A role for the MEK-MAPK pathway in okadaic acid-induced meiotic resumption of incompetent growing mouse oocytes
    C de Vantéry Arrighi
    Clinique de Stérilité et d Endocrinologie Gynécologique, Département de gynécologie et obstétrique, Maternité, Hopitaux Universitaires de Geneve, 1211 Geneve 14, Switzerland
    Biol Reprod 63:658-65. 2000
    ..promoting factor (MPF; [p34(cdc2)/cyclin B kinase]) and mitogen-activated protein (MAP) kinases (p42(MAPK) and p44(MAPK)), are implicated in meiotic competence acquisition...
  24. ncbi Activation of p44/42 mitogen activated protein kinases in thrombin-induced brain tolerance
    G Xi
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0532, USA
    Brain Res 895:153-9. 2001
    ..The aim of the current study is to investigate whether thrombin-induced tolerance (thrombin preconditioning; TPC) is associated with activation of p44/42 mitogen activated protein (MAP) kinases.
  25. ncbi Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats
    Shun Guang Wei
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hypertension 52:679-86. 2008
    ..study examined the hypothesis that the angiotensin II (Ang II)-triggered mitogen-activated protein kinases (MAPKs) p44/42, p38, and c-Jun N-terminal kinase contribute to upregulation of the AT(1)-R in the hypothalamus of rats with HF...
  26. ncbi Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector
    Mong Ping Shyong
    Institute of Clinical Medicine, National Yang Ming University, Taipei and Su Ao Veterans Hospital, I Lan, Taiwan
    Mol Vis 13:133-41. 2007
    ..To evaluate the efficacy of recombinant adeno-associated virus (rAAV) vector expressing mouse angiostatin (Kringle domains 1 to 4) in reducing retinal vascular leakage in an experimental diabetic rat model...
  27. ncbi Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion
    Luis H Toledo-Pereyra
    Borgess Research Institute, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49048, USA
    J Invest Surg 17:303-13. 2004
    ..Chemokine expression (MIP-1alpha, MIP-1beta, MIP-2 and KC), Akt, MAPK (p44/p42), and RSK expressions were also measured in liver tissue by enzyme-linked immunosorbent assay (ELISA) and ..
  28. ncbi Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells
    Robin R Hodges
    Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 85:836-44. 2007
    ..Transactivation of the EGF receptor activates a kinase cascade culminating in the activation of p42/p44 MAPK (MAPK) and ultimately that leads to secretion of high molecular weight glycocongujates (HMWGC), including ..
  29. ncbi Two monoclonal antibodies with defined epitopes of P44 major surface proteins neutralize Anaplasma phagocytophilum by distinct mechanisms
    Xueqi Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210 1093, USA
    Infect Immun 74:1873-82. 2006
    ..phagocytophilum are dominant antigens recognized by patients and infected animals. However, the ability of anti-P44 antibody to neutralize the infection has been unclear due to a mixture of P44 proteins with diverse hypervariable ..
  30. ncbi Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming
    Wai Ki Yiu
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Vasc Surg 46:557-564. 2007
    ..This study investigated the differential effects of vascular cell survival and proliferation in an in vitro model simulating cryoplasty...
  31. ncbi Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, M D Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    J Biol Chem 281:19798-808. 2006
    ..Further, the deletion of NQO1 abolished TNF-induced c-Jun N-terminal kinase, Akt, p38, and p44/p42 mitogen-activated protein kinase activation...
  32. ncbi Bradykinin and high glucose promote renal tubular inflammation
    Sydney C W Tang
    Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrol Dial Transplant 25:698-710. 2010
    ..The role of the kallikrein-kinin system in diabetic nephropathy remains controversial. Methods and..
  33. ncbi Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK
    Robin R Hodges
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3352-9. 2006
    Although p42/p44 mitogen-activated protein kinase (MAPK) negatively modulates protein secretion stimulated by cholinergic and alpha(1D)-adrenergic agonists, it does not play a role in epidermal growth factor (EGF)-stimulated protein ..
  34. ncbi In-vitro studies on the susceptibility of ovine strains of Anaplasma phagocytophilum to antimicrobial agents and to immune serum
    Z Woldehiwet
    Department of Comparative Molecular Medicine, University of Liverpool, School of Veterinary Science, Neston, Wirral, UK
    J Comp Pathol 143:94-100. 2010
    ..of infection of Giemsa-stained antibiotic-treated and untreated cells and by comparing the number of copies of the p44 gene by real-time polymerase chain reaction using p44-specific primers...
  35. ncbi Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells
    Diane L Carlisle
    Department of Pharmacology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Pulm Pharmacol Ther 20:629-41. 2007
    ..Nicotine at a concentration of 10 microM caused phosphorylation of mitogen-activated protein kinase (MAPK) (p44/42) that could be inhibited using nAChR antagonists...
  36. ncbi p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes
    A M Engelbrecht
    Department of Physiological Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
    Basic Res Cardiol 99:338-50. 2004
    ..strong, biphasic activation of p38 concomitant with a weak and transient activation of the two ERK isoenzymes, p42/p44-MAPK...
  37. ncbi Mechanisms of variable p44 expression by Anaplasma phagocytophilum
    Quan Lin
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Infect Immun 71:5650-61. 2003
    ..bacterium Anaplasma phagocytophilum promotes variation of P44s, which are surface-exposed proteins encoded by a p44 multigene family. In the present study, the specific p44 gene expression loci in four strains of A...
  38. ncbi Transcript heterogeneity of the p44 multigene family in a human granulocytic ehrlichiosis agent transmitted by ticks
    Ning Zhi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1093, USA
    Infect Immun 70:1175-84. 2002
    ..Overall, a total of 20 different p44 transcripts were detected in the mammals, ticks, and cell cultures...
  39. ncbi Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: involvement of the DNA binding protein ApxR
    Xueqi Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    J Bacteriol 189:8651-9. 2007
    ..The present study investigated regulation of A. phagocytophilum p44 genes, which encode the P44 major surface proteins...
  40. ncbi Structural analysis of a p44/msp2 expression site of Anaplasma phagocytophilum in naturally infected ticks in Japan
    - Wuritu
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka and Global COE Program, Shizuoka 422 8526, Japan
    J Med Microbiol 58:1638-44. 2009
    ..The genome of this bacterium contains a large number of p44/msp2-related genes encoding 44 kDa major outer-membrane proteins, and it is known that a specific p44/msp2 gene is ..
  41. ncbi The mouse p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1) gene. Genomic organization and structure of the 5'-flanking regulatory region
    G Pages
    Centre de Biochimie, CNRS UMR134, Nice, France
    J Biol Chem 270:26986-92. 1995
    ..We report here the cloning of the murine p44 MAP kinase (extracellular signal-regulated kinase 1) gene, the determination of its intron/exon boundaries, and the ..
  42. ncbi Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006
    ..Therefore, we investigated their role in p42/p44 MAPK signaling and proliferation using human ASM cell lines...
  43. ncbi Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    J Cancer Res Clin Oncol 135:791-8. 2009
    ....
  44. ncbi Activation of beta(2)-adrenoceptor prevents shiga toxin 2-induced TNF-alpha gene transcription
    A Nakamura
    Department of Paediatrics, Teikyo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 12:2288-99. 2001
    ..Stx-2 (4 pg/ml) stimulated MAPK (p42/p44, p38) and AP-1 and increased TNF-alpha promoter activity by 2.4-fold...
  45. ncbi Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:39541-54. 2004
    ..Deletion of GSK-3beta also abolished TNF-induced c-Jun N-terminal kinase and p44/p42 mitogen-activated kinase activation...
  46. ncbi High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts
    Kazuhiro Omori
    Department of Pathophysiology, Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8525, Japan
    J Biol Chem 279:6643-9. 2004
    ..Furthermore, the HG condition enhanced the IL-6/sIL-6R-induced phosphorylation of p44/42 MAPK and led to subsequent activation of CCAAT/enhancer binding protein in nuclei...
  47. ncbi Ligand-independent activation of steroid receptors
    A P F Flint
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics LE12 5RD, UK
    Domest Anim Endocrinol 23:13-24. 2002
    ..various times following transfection, and MAP kinase phosphorylation was monitored by western blotting of p42 and p44. The MEK inhibitor U 0126 was used to determine whether the effect of IGF-I on CATERE expression was mediated ..
  48. ncbi Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells
    Tusty Jiuan Hsieh
    Research Centre, Centre Hospitalier de l Universite de Montreal CHUM, Hotel Dieu, 3850 Saint Urbain Street, Montreal, Quebec H2W 1T8, Canada
    J Endocrinol 183:535-50. 2004
    ..Phosphorylation of p44/42 mitogen-activated protein kinase (p44/42 MAPK) was evaluated by western blotting...
  49. ncbi Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells
    Kirti Chaturvedi
    Endocrinology Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Endocrinology 145:706-15. 2004
    ..Estradiol and TGF-beta3 alone moderately activated MAPK p44/42; together they produced marked activation of MAPK p44/42...
  50. ncbi Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells
    C M Yang
    Cellular and Molecular Pharmacology Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, Kwei San, Taiwan
    Cell Signal 12:205-14. 2000
    ..with a specific pattern of mitogen-activated protein kinase (MAPK) by [3H]thymidine incorporation and p42/p44 MAPK phosphorylation in canine cultured VSMCs...
  51. ncbi Inhibition of IL-8-mediated MAPK activation in human neutrophils by beta1 integrin ligands
    Demetra Xythalis
    Center for Cell Biology and Cancer Research, Albany Medical College, NY 12208, USA
    Inflammation 26:83-8. 2002
    ..to the activation of heterotrimeric G proteins that initiate multiple signaling cascades, including p38 and p42/p44 mitogen-activated protein kinase (MAPK) pathways...
  52. ncbi Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity
    F Vinals
    Centre de Biochimie CNRS UMR 6543, Universite de Nice, 06108 Nice, France
    Mol Cell Biol 19:2763-72. 1999
    ..In this work, we have studied the effect of cellular contact on the activation of p42/p44 mitogen-activated protein kinase (MAPK) by growth factors in mouse vascular endothelial cells...
  53. ncbi Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
    C C Chen
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 58:1479-89. 2000
    ..Treatment of cells with IL-1beta resulted in stimulation of p44/42 MAPK, p38, and JNK...
  54. ncbi Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism
    Claire Jacob
    Pfizer Global R and D, Fresnes Laboratories, Department of Biology, 3 9 Rue de la Loge, 94265 Fresnes, France
    Br J Pharmacol 143:257-68. 2004
    ..We also observed that the inhibition of p44/42(MAPK) by PD98059 (1-10 microm) increased O(2)(*-) release by BAL cells enriched in neutrophils, but not by ..
  55. ncbi Structure of the expression site reveals global diversity in MSP2 (P44) variants in Anaplasma phagocytophilum
    Anthony F Barbet
    Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611 0880, USA, and Department of Clinical Microbiology, Kalmar County Hospital, Sweden
    Infect Immun 74:6429-37. 2006
    ..number of related genes and gene fragments encoding partial or apparently full-length outer membrane protein MSP2 (P44)...
  56. ncbi Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Biochem 112:559-70. 2011
    ..We also observed that EV71-induced p42/p44 MAPK phosphorylation was decreased following pretreatment with AG1478...
  57. ncbi Differential expression and glycosylation of anaplasma phagocytophilum major surface protein 2 paralogs during cultivation in sialyl Lewis x-deficient host cells
    Matthew J Troese
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Kontos Medical Sciences Building, 1217 East Marshall Street, Room 215, Richmond, VA 23298 0678, USA
    Infect Immun 77:1746-56. 2009
    ..A. phagocytophilum major surface protein 2 [Msp2(P44)] is encoded by members of a paralogous gene family and is speculated to play roles in host adaptation...
  58. ncbi p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
    C C Chen
    Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 55:481-8. 1999
    ..7 macrophages. The role of mitogen-activated protein kinases (MAPK) p44/42 and p38 in the LPS effect was studied further...
  59. ncbi Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD14 and TLR-4 receptor activation in human gingival fibroblasts
    Gloria Gutiérrez-Venegas
    Laboratorio de Bioquímica División de Estudios de Posgrado Facultad de Odontología Universidad, Nacional Autónoma de México México, D F 04510
    Life Sci 78:2577-83. 2006
    ..with the tyrosine kinase inhibitors, herbimycin A and genistein inhibited the LPS-stimulated phosphorylation of p44 and p42 MAP kinases in a dose dependent manner...
  60. ncbi Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus
    C L Hou
    Institute of Life Science, National Defense Medical Center, and the Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Blood 96:747-53. 2000
    ..1R as bait in a yeast 2-hybrid screen, we isolated cDNA clones encoding a polypeptide of eIF3-p44, which represents a subunit of a eukaryotic translation initiation factor 3 (eIF3) complex...
  61. ncbi Differential phosphorylation of the rhodopsin cytoplasmic tail mediates the binding of arrestin and its splice variant, p44
    Maria Ascano
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA
    Biochemistry 45:2398-407. 2006
    ..kinase and subsequently deactivated by the binding of the regulatory protein arrestin or its splice variant, p44. Although much is known about the overall differences between arrestin and p44 binding to different rhodopsin ..
  62. ncbi CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 20:7587-94. 2000
    ..alpha (TNF-alpha) production and nitric oxide (NO) release, both of which we show to be dependent on activation of p44/42 mitogen-activated protein kinase (MAPK)...
  63. ncbi Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells
    Shen Gao
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e49173. 2012
    ..We previously identified a 44-kDa protein (p44/wdr77) as an androgen receptor-interacting protein that regulates a set of androgen receptor target genes in prostate ..
  64. ncbi Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA--role of MAPK and NF-kappaB
    Joseph C K Leung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Nephrol Dial Transplant 23:72-81. 2008
    ..In the present study, the functional consequences of the binding of anionic polymeric IgA1 to human mesangial cells (HMCs) were investigated...
  65. ncbi (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation
    Haruhiko Tokuda
    Department of Clinical Laboratory, National Hospital for Geriatric Medicine, National Center for Geriatrics and Gerontology, Obu 474 8511, Japan
    FEBS Lett 581:1311-6. 2007
    ..a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells, and that protein kinase C (PKC)-dependent p44/p42 mitogen-activated protein (MAP) kinase plays a part in the IL-6 synthesis...
  66. ncbi RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity
    Gernot Guderian
    Department of Biochemistry, Biocenter of the University of Wurzburg, D 97074 Wurzburg, Germany
    J Biol Chem 286:1976-86. 2011
    ..The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of its substrate proteins...
  67. ncbi Activation of p44/42 MAPK plays a role in the TBT-induced loss of human natural killer (NK) cell function
    Fred D Dudimah
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    Cell Biol Toxicol 26:435-44. 2010
    ..TBT) decreases the lytic function of NK cells and activates mitogen-activated protein kinases (MAPK), including p44/42 (Aluoch and Whalen Toxicology 209:263-277, 2005)...
  68. ncbi Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts
    Hiroyuki Eda
    Discovery Biology, Global Research and Development, St Louis Laboratories, Pfizer Inc, 700 Chesterfield Parkway West, mail zone AA3C, Chesterfield, MO 63017, USA
    Rheumatol Int 31:1525-30. 2011
    ..IL-1β and TNF-α activated the intracellular mitogen-activated protein kinases (MAPKs): p44/42 MAPK, p38, and c-Jun N-terminal kinase (JNK) as well as nuclear factor-κB (NF-κB) in osteoblasts...
  69. ncbi SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53
    Archana Jalota-Badhwar
    National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007, India
    J Biol Chem 282:9902-13. 2007
    ..Here we report one such 44-mer peptide sequence of SMAR1 (TAT-SMAR1 wild type, P44) that retains the tumor suppressor activity of the full-length protein...
  70. ncbi Angiotensin II activates p44/42 MAP kinase partly through PKCepsilon in H295R cells
    Jean Guy LeHoux
    Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Mol Cell Endocrinol 265:121-5. 2007
    ..we have previously reported that in H295R cells, (a) angiotensin II (AII) activates PKCepsilon, PKCalpha and p44/42 MAPK pathway, (b) PKCepsilon, PKCalpha and p44/42 MAPK overexpression inhibits AII-induced CYP11B2 gene ..
  71. ncbi Cloning of the major outer membrane protein expression locus in Anaplasma platys and seroreactivity of a species-specific antigen
    Tzung Huei Lai
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1093, USA
    J Bacteriol 193:2924-30. 2011
    ..In this study, we cloned the A. platys major outer membrane protein cluster, including the P44/Msp2 expression locus (p44ES/msp2ES) and outer membrane protein (OMP), using DNA isolated from the blood of four ..
  72. ncbi Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway
    Mahlon D Johnson
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Rochester Medical Center, Rochester, New York 14623, USA
    J Neurosurg 112:934-9. 2010
    ..Fibroblast growth receptor-3 has not been demonstrated in the human CNS or its tumors. Nonetheless, it has been implicated in the pathogenesis of several other forms of neoplasia...
  73. ncbi Oxidized low-density lipoprotein induces matrix metalloproteinase-9 expression via a p42/p44 and JNK-dependent AP-1 pathway in brain astrocytes
    Hui Hsin Wang
    Department of Pharmacology, Chang Gung University, Tao Yuan, Taiwan
    Glia 57:24-38. 2009
    ..blotting analyses showed that oxLDL-induced proMMP-9 gene expression was mediated through Akt, JNK1/2, and p42/p44 MAPK phosphorylation in RBA-1 cells...
  74. ncbi Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide
    C J Lo
    Department of Surgery, University of California, Los Angeles, USA
    JPEN J Parenter Enteral Nutr 24:159-63. 2000
    ..Overactivity of MAPK has been implicated in the development of many diseases, including cancer and sepsis. This study investigated the hypothesis that fish oil altered the membrane phospholipid composition and modulated MAPK activity...
  75. ncbi Hydrogen peroxide increases [3H]-2-deoxyglucose uptake via MAPKs, cPLA2, and NF-kappaB signaling pathways in mouse embryonic stem cells
    Sun Im Na
    Department of Veterinary Physiology, Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University
    Cell Physiol Biochem 20:1007-18. 2007
    ..Indeed, H(2)O(2) increased the mRNA and protein level of glucose transporter 1 (GLUT 1). PD 98059 (a p44/42 MAPKs inhibitor, 10-5 M), SB 203580 (a p38 MAPK inhibitor, 10-6 M), and SP 600125 (a SAPK/JNK inhibitor, 10-6 M) ..
  76. ncbi Novel 44-kilodalton subunit of axonemal Dynein conserved from chlamydomonas to mammals
    Ryosuke Yamamoto
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Eukaryot Cell 7:154-61. 2008
    ..Dynein d was found to associate with two additional proteins of 38 kDa (p38) and 44 kDa (p44). Following the characterization of the p38 protein (R. Yamamoto, H. A. Yanagisawa, T. Yagi, and R...
  77. ncbi mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A
    Franklin C Harwood
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    J Biol Chem 283:2575-85. 2008
    The mTORC1 complex (mammalian target of rapamycin (mTOR)-raptor) is modulated by mitogen-activated protein (p44/42 MAP) kinases (p44/42) through phosphorylation and inactivation of the tuberous sclerosis complex...
  78. ncbi Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway
    Julie Chenal
    Department of Physiology, Universite de Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    Eur J Neurosci 27:53-65. 2008
    ..of the putative signalling pathways leading to translation activation revealed that insulin and IGF-1 induced p44- and p42 MAPK, Akt and mTOR phosphorylation...
  79. ncbi Tumour-mediated disruption of dendritic cell function: inhibiting the MEK1/2-p44/42 axis restores IL-12 production and Th1-generation
    Andrew Mark Jackson
    Academic Unit of Clinical Oncology, University of Nottingham, City Hospital, Nottingham, United Kingdom
    Int J Cancer 123:623-32. 2008
    ..The p44/42 MAPK was hyper-activated by melanoma lysate, but not that of HUVEC...
  80. ncbi Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma
    N Friedrichs
    Department of Pathology, University of Bonn Medical Centre, Bonn, Germany
    J Pathol 216:428-39. 2008
    ..cascade are known to be involved in the transmission of IGF-1R signals, expression of phosphorylated (p)-AKT and p-p44/42 MAPK was additionally assessed. All tumours expressed IGF-2 and 78% showed an activated IGF-1R...
  81. ncbi Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland
    Chika Funaki
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 293:C1551-60. 2007
    ..In the present study we determined whether cAMP decreases p44/p42 mitogen-activated protein kinase (MAPK) activity in the lacrimal gland...
  82. ncbi Thrombin up-regulates vascular endothelial growth factor in experimental gliomas
    Ying Xu
    Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA Department of Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Neurol Res 31:759-65. 2009
    ..endothelial growth factor is a potent stimulator of angiogenesis; activation of hypoxia inducible factor-1alpha and p44/42 mitogen-activated protein kinase pathways has been associated with vascular endothelial growth factor production...
  83. ncbi Nuclear transport signals control cellular localization and function of androgen receptor cofactor p44/WDR77
    Zhongping Gu
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e22395. 2011
    The androgen receptor (AR) cofactor p44/WDR77, which regulates expression of a set of androgen target genes, is required for differentiation of prostate epithelium...
  84. ncbi Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein
    Takeo Minaguchi
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Case Western Reserve University School of Medicine, Cleveland, Ohio 44195, USA
    Cancer Res 66:11677-82. 2006
    ..that nuclear phosphatase and tensin homologue deleted on chromosome 10 (PTEN) down-regulates phosphorylation of p44/42 and cyclin D1 and induces G(1) cell cycle arrest, whereas cytoplasmic PTEN down-regulates phosphorylation of Akt,..
  85. ncbi Porin activity of Anaplasma phagocytophilum outer membrane fraction and purified P44
    Haibin Huang
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 189:1998-2006. 2007
    ..disaccharide sucrose, and even the tetrasaccharide stachyose, and this diffusion could be inhibited with an anti-P44 monoclonal antibody. P44s are the most abundant outer membrane proteins and neutralizing targets of A...
  86. ncbi Epidermal growth factor inhibits 14C-alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells: involvement of PLC/PKC, p44/42 MAPK, and cPLA2
    Ho Jae Han
    Department of Veterinary Physiology, College of Veterinary Medicine, Hormone Research Center, Chonnam National University, Gwangju, Korea
    J Cell Physiol 199:206-16. 2004
    ..Indeed, EGF increased phosphorylation of p44/p42 MAPK and the EGF-induced inhibition of alpha-MG uptake as well as the stimulatory effect of EGF on AA release ..
  87. ncbi Functional expression of adenosine A2A and A3 receptors in the mouse dendritic cell line XS-106
    John M Dickenson
    Department of Life Sciences, Faculty of Science and Mathematics, School of Science, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    Eur J Pharmacol 474:43-51. 2003
    ..inhibited forskolin-mediated [3H]cyclic AMP accumulation and stimulated concentration-dependent increases in p42/p44 mitogen-activated protein kinase (MAPK) phosphorylation...
  88. ncbi Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta
    A Kitamura
    Institute for Liver Research, Kansai Medical University, Osaka, Japan
    Eur J Biochem 224:877-83. 1994
    A hepatitis-C-associated microtubular aggregate protein, referred to as p44, has been identified as a cytoplasmic antigen in the hepatocytes of chimpanzees infected with hepatitis C virus...
  89. ncbi OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells
    Ming Wei Chien
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Lipid Res 44:1667-75. 2003
    ..stimulates multiple signaling pathways, including activation of phosphatidylinositol 3-kinase (PI3-K)/Akt and p42/p44 mitogen-activated protein kinase (MAPK), which are involved in mitogenesis of vascular smooth muscle cells (VSMCs)...
  90. ncbi Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts
    H Tokuda
    Department of Internal Medicine, Chubu National Hospital National Institute for Longevity Sciences, Obu, Aichi 474 8511, Japan
    J Endocrinol 177:101-7. 2003
    We previously reported that basic fibroblast growth factor (FGF-2) activates p44/p42 mitogen-activated protein (MAP) kinase resulting in the stimulation of vascular endothelial growth factor (VEGF) release in osteoblast-like MC3T3-E1 ..
  91. ncbi Expression of multiple outer membrane protein sequence variants from a single genomic locus of Anaplasma phagocytophilum
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, PO Box 110880, Gainesville, FL 32611, USA
    Infect Immun 71:1706-18. 2003
    ..The major outer membrane protein of A. phagocytophilum, MSP2(P44), is homologous to MSP2 of A...
  92. ncbi Bradykinin B2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells
    Chuen Mao Yang
    Department of Physiology Pharmacology, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan, ROC
    J Biomed Sci 10:208-18. 2003
    ..Both [(3)H]thymidine incorporation and p42/p44 MAPK phosphorylation were activated by BK in time- and concentration-dependent manners...
  93. ncbi The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors
    L Bianchini
    Centre de Biochimie, CNRS, Universite de Nice, France
    J Biol Chem 272:271-9. 1997
    ..Whereas p44 MAPK does not appear to phosphorylate NHE1 in vitro, we found that inhibition of the p42/p44 MAPK signaling by ..
  94. ncbi Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells
    Catherine Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, Scotland, United Kingdom
    J Biol Chem 278:6282-90. 2003
    ..Second, treatment of airway smooth muscle cells with PDGF stimulated the phosphorylation of p42/p44 MAPK, and this phosphorylated p42/p44 MAPK associates with the PDGF beta receptor-S1P(1) receptor complex...
  95. ncbi Activation of a p44 pseudogene in Anaplasma phagocytophila by bacterial RNA splicing: a novel mechanism for post-transcriptional regulation of a multigene family encoding immunodominant major outer membrane proteins
    Ning Zhi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, 1925 Coffey Road, 43210 1093, USA
    Mol Microbiol 46:135-45. 2002
    ..outer membrane proteins of Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) are encoded by the p44 multigene family. One of the paralogues, p44-18 is predominantly expressed by A...
  96. ncbi [Recombinant human interleukin-10 inhibits vascular smooth muscle cell proliferation induced by TNF-alpha]
    Ping Ouyang
    College of Life Science, Zhong Shan University, Guangzhou 510275
    Sheng Li Xue Bao 54:79-82. 2002
    ..of recombinant human interleukin-10 (rhIL-10) on rat vascular smooth muscle cell proliferation and the activity of p44/p42 mitogen-activated protein kinase (MAPK) promoted by tumor necrosis factor-alpha (TNF-alpha)...
  97. ncbi Cardioprotective effects of transforming growth factor-beta1 during early reoxygenation or reperfusion are mediated by p42/p44 MAPK
    G F Baxter
    The Hatter Institute, University College, Grafton Way, London WC1E 6DB, U K
    J Cardiovasc Pharmacol 38:930-9. 2001
    ..the effects of transforming growth factor-beta1 (TGF-beta1) on reperfusion injury and assessed the role of p42/p44 MAPK signaling in TGF-beta1-induced protection...
  98. ncbi Signaling pathways leading to the induction of ornithine decarboxylase: opposite effects of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitors
    F Flamigni
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, 40126, Bologna, Italy
    Biochem Pharmacol 61:25-32. 2001
    ..All these agents also provoked an increase in active phosphorylated p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK...
  99. ncbi 5-hydroxytryptamine stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures
    J E McDuffie
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Cardiovasc Pharmacol 35:398-402. 2000
    ..acts as an endothelial cell mitogen, promotes the release of nitric oxide (NO), and has been associated with the p44/p42 mitogen-activated protein kinase (MAPK) cascade...
  100. ncbi The p44/42 mitogen-activated protein kinase cascade is involved in the induction and maintenance of astrocyte stellation mediated by protein kinase C
    K Abe
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Neurosci Res 36:251-7. 2000
    ..To understand the role of p44/42 MAPK (ERK1/2) in astrocyte differentiation, we investigated the effects of U0126 and PD98059, specific ..
  101. ncbi Early intracellular signalling pathway of ethanol in vascular smooth muscle cells
    A Sachinidis
    Medizinische Universitäts Poliklinik, Wilhelmstr 35 37, 53111 Bonn, Germany
    Br J Pharmacol 128:1761-71. 1999
    ..Although ethanol has been shown to modulate ERK1 and ERK2 (p44(mapk) and p42(mapk)) activity, it can also act as an antiproliferative agent in various mammalian cells...

Research Grants70

  1. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
    ..three mitogen activated protein kinase (MAPK) cascades in rat acini leading to activation of ERKs (p42 and p44 MAPK), Jun Kinase and p38/Reactivating Kinase...
  2. ETHANOL AND MAP KINASE CASCADE
    SHIVENDRA SHUKLA; Fiscal Year: 2003
    ..This is not due to upregulation of MAPK protein or physical interaction between ethanol and MAPK (p42 and p44) and therefore may be due to modulation on post-receptor signaling steps...
  3. Dual Proteasome and MAPK Inhibition in Cancer Therapy
    Robert Orlowski; Fiscal Year: 2007
    ..likely trigger apoptosis through several pathways, our recent work implicates an important role for inhibition of p44/42 MAPK by induction of MKP phosphatases...
  4. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    ..agonist-induced cell proliferation will be studied using immunoblotting to probe for activated proteins in the p44/42 MARK, p38 MARK and JNK pathways, and by examining the roles of phospholipase C and protein kinase C activation ..
  5. NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
    DAVID KAETZEL; Fiscal Year: 2003
    ..We have also observed binding of a number of other protein species (p97, p87, p70, p44/48) to the 5'SHS silencer element...
  6. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..Their recent study indicates that there are a total of approximately 18 copies of p44 genes and the HGE agent in a human promyelocytic leukemia cell line, HL-60, expresses 5 of them...
  7. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Furthermore, EGFR-mediated-p44/42 MAPK signaling phosphorylates and activates the RNA binding protein, CUGBP1, which then binds to C/EBPB mRNA to ..
  8. MECHANISMS OF THROMBIN INDUCED TOLERANCE TO BRAIN INJURY
    Guohua Xi; Fiscal Year: 2002
    ..TPC activates p38 mitogen activated protein kinase (p38 MAP kinase) and extracellular signal regulated kinase (ERK) p44/42 MAP kinase; 4) TPC-induced brain tolerance may be through thrombin receptor activation; 5) TPC also reduces ..
  9. METABOLIC REGULATION OF APOLIPOPROTEIN B MRNA EDITING
    Harold Smith; Fiscal Year: 1999
    ..Preliminary data demonstrate production of antibodies reactive with p240 and p44, cloning and sequencing of cDNAs for p44 and p27...
  10. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009
    ..and determine whether leptin enhanced signaling via the PI-3K/Akt and extracellular regulated kinase (Erk, p44/p42), and p38 pathways are directly inhibited as assessed by HSC proliferation and apoptosis.(2)...
  11. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009
    ..and determine whether leptin enhanced signaling via the PI-3K/Akt and extracellular regulated kinase (Erk, p44/p42), and p38 pathways are directly inhibited as assessed by HSC proliferation and apoptosis.(2)...
  12. Rationally designed Rift Valley Fever Virus Vaccine
    Ramon Flick; Fiscal Year: 2007
    ..hypothesis is based on the finding that interferon antagonistic action of NSs occurs via its interaction with p44 a component of the transcription factor TFIIH...
  13. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2010
    ..and determine whether leptin enhanced signaling via the PI-3K/Akt and extracellular regulated kinase (Erk, p44/p42), and p38 pathways are directly inhibited as assessed by HSC proliferation and apoptosis.(2)...
  14. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
    ..by expression of dominant negative Ras or MAPK ohosphatase -2, yet is unaffected by inhibition of the classic p44/p42 MAPK cacade...
  15. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ..In murine tumor models, blockade of amphoterin/RAGE suppresses activation of members of the kinase family, p44/p42, p38 and SAPKIJNK involved in modulating tumor proliferation, invasion/migration, and activation of matrix ..
  16. RAGE and modulation of tumor properties
    Emina Huang; Fiscal Year: 2006
    ..In murine tumor models, blockade of amphoterin/RAGE suppressed activation of members of the MAP kinase family, p44/p42, p38 and SAPK/JNK, involved in tumor cell proliferation, invasion/migration, and activation of matrix ..
  17. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..rat and human conjunctival goblet cells will be used to determined if EGF stimulates proliferation by activating 1) p44/p42 mitogen-activated protein kinase, (2) phosphatidylinositol-3 kinase, or (3) PKC isoforms, Proliferation will be ..
  18. AIRWAY MYOCYTE PROLIFERATION AND LYSOSOMAL HYDROLASE
    DUKHEE LEW; Fiscal Year: 2001
    ..Specific aims are: 1) To determine the contribution of p42 and p44 mitogen activated protein kinases (p42/44MAPK) and 70-kD ribosomal protein S6 kinase (p70S6k) in mannosyl-rich ..
  19. SIGNALING MECHANISMS IN PHARMACOLOGICAL PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2004
    ..hypothesis is that pharmacological triggers of PC activate signaling pathway leading to phosphorylation of p38, p44 and p42 MAP kinases and also cause their translocation in the nucleus...