Gene Symbol: WDR59
Description: WD repeat domain 59
Alias: CDW12, FP977, p90-120, GATOR complex protein WDR59, CDw12 antigen, WD repeat-containing protein 59
Species: human
Products:     WDR59

Top Publications

  1. Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin Brureau M, An Gourfinkel I, et al. Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia. 2016;57:994-1003 pubmed publisher
    ..genes encoding the components of the GATOR1 (DEPDC5, NPRL2, and NPRL3) and GATOR2 (MIOS, SEC13, SEH1L, WDR24, and WDR59) complex in 93 European probands with focal epilepsy with or without focal cortical dysplasia...
  2. Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher
    ..corrected by overexpression of the GATOR1 component DEPDC5, and by the lysosome-targeted GATOR2 component WDR59 or lysosome-targeted SESN2...
  3. Monies D, Abouelhoda M, AlSayed M, Alhassnan Z, Alotaibi M, Kayyali H, et al. The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes. Hum Genet. 2017;136:921-939 pubmed publisher
    ..RNF213, ROBO1, SEC16A, SIAH1, SIRT2, SLAIN2, SLC22A20, SMDT1, SRRT, SSTR1, ST20, SYT9, TSPAN6, UBR4, VAMP4, VPS36, WDR59, WDYHV1, and WHSC1) not previously linked to human phenotypes and these are presented to accelerate post-..
  4. Marinov J, Koubek K, Stary J. Expression of CDw12 and CD17 cell surface antigens on leukemic cells from patients with blood malignancies. Folia Biol (Praha). 1993;39:124-8 pubmed
    ..the expression and distribution of 2 relatively incompletely studied antigenic markers from the CD nomenclature: CDw12 and CD17, individually and in combination with well characterized ones...
  5. Bar Peled L, Chantranupong L, Cherniack A, Chen W, Ottina K, Grabiner B, et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013;340:1100-6 pubmed publisher
    ..In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, and Sec13) suppresses mTORC1 signaling, and epistasis analysis shows that GATOR2 negatively regulates ..
  6. Chantranupong L, Scaria S, Saxton R, Gygi M, Shen K, Wyant G, et al. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell. 2016;165:153-164 pubmed publisher
    ..Collectively, these results establish CASTOR1 as an arginine sensor for the mTORC1 pathway. ..