VTA1

Summary

Gene Symbol: VTA1
Description: vesicle trafficking 1
Alias: C6orf55, DRG-1, DRG1, HSPC228, LIP5, My012, SBP1, vacuolar protein sorting-associated protein VTA1 homolog, LYST-interacting protein 5, SKD1-binding protein 1, Vps20-associated 1 homolog, dopamine-responsive gene 1 protein, homolog of mouse SKD1-binding protein 1, vesicle (multivesicular body) trafficking 1
Species: human
Products:     VTA1

Top Publications

  1. Wang J, Ji X, Liu J, Zhang X. Serine/Threonine Protein Kinase STK16. Int J Mol Sci. 2019;20: pubmed publisher
    ..characterization, post-translational modification (fatty acylation and phosphorylation), interactors (GlcNAcK/DRG1/MAL2/Actin/WDR1), and related functions...
  2. Matsuoka T, Yoshida N. Functional analysis of putative transporters involved in oligotrophic growth of Rhodococcus erythropolis N9T-4. Appl Microbiol Biotechnol. 2019;103:4167-4175 pubmed publisher
    ..constructed the gene-deletion mutants of a gene encoding the substrate-binding protein for each ABC transporter (∆sbp1, ∆sbp2, and ∆sbp3)...
  3. Johri S, Solanki J, Cantú V, Fellows S, Edwards R, Moreno I, et al. 'Genome skimming' with the MinION hand-held sequencer identifies CITES-listed shark species in India's exports market. Sci Rep. 2019;9:4476 pubmed publisher
    ..genes for antithrombin or SerpinC, Immunoglobulin lambda light chain, Preprogehrelin, selenium binding protein 1(SBP1), Interleukin-1 beta (IL-1β) and Recombination-Activating Gene 1 (RAG1)...
  4. Wei W, Bracher Manecke J, Zhao X, Davies N, Zhou L, Ai R, et al. Oncogenic but non-essential role of N-myc downstream regulated gene 1 in the progression of esophageal squamous cell carcinoma. Cancer Biol Ther. 2013;14:164-74 pubmed publisher
    ..Taken together, our results suggest that NDRG1 may play positive but dispensable roles in the progression of esophageal squamous cell carcinoma. ..
  5. Van C, Thanh T, Zou G, Jia M, Wang Q, Zhang L, et al. Characterization of serotypes and virulence genes of Haemophilus parasuis isolates from Central Vietnam. Vet Microbiol. 2019;230:117-122 pubmed publisher
    ..8%), followed by serotype 2 (13/56, 23.2%) and serotype 4 (10/56, 17.9%). The vta1 was the most frequently detected virulence gene which was present in 62.5% of the strains, followed by vta3 (42...
  6. McCullough J, Fisher R, Whitby F, Sundquist W, Hill C. ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A. 2008;105:7687-91 pubmed publisher
    ..different ESCRT-III subunits to bind different ESCRT pathway partners, with CHMP1-3 proteins binding MIT domain-containing proteins, such as VPS4 and Vta1/LIP5, and CHMP4 proteins binding Bro1 domain-containing proteins, such as ALIX.
  7. Elhodaky M, Diamond A. Selenium-Binding Protein 1 in Human Health and Disease. Int J Mol Sci. 2018;19: pubmed publisher
    Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium...
  8. Chen H, Zhang R, Zheng Q, Yan X, Wu S, Chen Y. Impact of body mass index on long-term blood pressure variability: a cross-sectional study in a cohort of Chinese adults. BMC Public Health. 2018;18:1193 pubmed publisher
    ..The average real variability of systolic blood pressure (ARVSBP) was calculated as (|sbp2 - sbp1| + |sbp3 - sbp2 | + |sbp4 - sbp3| + |sbp5 - sbp4|)/4...
  9. Markolovic S, Zhuang Q, Wilkins S, Eaton C, Abboud M, Katz M, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nat Chem Biol. 2018;14:688-695 pubmed publisher
    ..of the translation factor (TRAFAC) family of GTPases, developmentally regulated GTP-binding proteins 1 and 2 (DRG1/2), as activity-dependent JMJD7 interactors...

More Information

Publications71

  1. Kreida S, Roche J, Olsson C, Linse S, Törnroth Horsefield S. Protein-protein interactions in AQP regulation - biophysical characterization of AQP0-CaM and AQP2-LIP5 complex formation. Faraday Discuss. 2018;209:35-54 pubmed publisher
    ..interaction between AQP0 and calmodulin, which mediates AQP0 gating, as well as the interaction between AQP2 and LIP5, which is involved in trafficking...
  2. Yang D, Hurley J. Structural role of the Vps4-Vta1 interface in ESCRT-III recycling. Structure. 2010;18:976-84 pubmed publisher
    ..Vps4 assembles on its membrane-bound ESCRT-III substrate with its cofactor, Vta1. The crystal structure of the dimeric VSL domain of yeast Vta1 with the small ATPase and the betadomains of Vps4 ..
  3. Kiniwa Y, Li J, Wang M, Sun C, Lee J, Wang R, et al. Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells. PLoS ONE. 2015;10:e0124094 pubmed publisher
    ..Taken together, these data suggest that DRG-1 plays an important role in melanoma cell growth and transformation, indicating that DRG1 may represent a novel target for CD4(+) T cell-mediated immunotherapy in melanoma.
  4. Wang Y, Fang W, Huang Y, Hu F, Ying Q, Yang W, et al. Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: a novel mechanism of cancer-specific cytotoxicity of selenite. Free Radic Biol Med. 2015;79:186-96 pubmed publisher
    ..investigate the roles of two distinct representatives of selenium-containing proteins, selenium-binding protein 1 (SBP1) and glutathione peroxidase 1 (GPX1), in selenite-mediated cancer-specific cytotoxicity...
  5. Shestakova A, Hanono A, Drosner S, Curtiss M, Davies B, Katzmann D, et al. Assembly of the AAA ATPase Vps4 on ESCRT-III. Mol Biol Cell. 2010;21:1059-71 pubmed publisher
    ..steps are mediated by a complex network of at least 12 distinct interactions between Vps4, ESCRT-III, Ist1, Vta1, and Did2. The order of events leading to active, ESCRT-III-associated Vps4 is poorly understood...
  6. Kats L, Proellocks N, Buckingham D, Blanc L, Hale J, Guo X, et al. Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells. Biochim Biophys Acta. 2015;1848:1619-1628 pubmed publisher
    ..We have previously shown that a resident MC protein, skeleton-binding protein 1 (SBP1), is essential for the placement of PfEMP1 onto the RBC surface and hypothesised that the function of SBP1 may be ..
  7. Hurley J. The ESCRT complexes. Crit Rev Biochem Mol Biol. 2010;45:463-87 pubmed publisher
    The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0, -I, -II, -III, and Vps4-Vta1, and the ALIX homodimer...
  8. Schild F, Kieffer Jaquinod S, Palencia A, Cobessi D, Sarret G, Zubieta C, et al. Biochemical and biophysical characterization of the selenium-binding and reducing site in Arabidopsis thaliana homologue to mammals selenium-binding protein 1. J Biol Chem. 2014;289:31765-76 pubmed publisher
    The function of selenium-binding protein 1 (SBP1), present in almost all organisms, has not yet been established. In mammals, SBP1 is known to bind the essential element selenium but the binding site has not been identified...
  9. Qian Y, Zhang Y, Yu Y, Li Q, Guo G, Fu Y, et al. SBP1 is an adhesion-associated factor without the involvement of virulence in Streptococcus suis serotype 2. Microb Pathog. 2018;122:90-97 pubmed publisher
    ..to the pathogenesis of SS2, but the function of another member in the srtBCD cluster, srtBCD-associated protein 1 (SBP1) was still unknown...
  10. Marino N, Collins J, Shen C, Caplen N, Merchant A, Gökmen Polar Y, et al. Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines. Clin Exp Metastasis. 2014;31:771-86 pubmed publisher
    ..validated MSGs (NME1, BRMS1, CD82, CDH1, CDH2, CDH11, CASP8, MAP2K4, MAP2K6, MAP2K7, MAPK14, GSN, ARHGDIB, AKAP12, DRG1, CD44, PEBP1, RRM1, KISS1), we identified genes whose expression was significantly opposite to at least five MSGs...
  11. Guo J, Li M, Sun Y, Yu L, He P, Nie Z, et al. Characterization of a novel secretory spherical body protein in Babesia orientalis and Babesia orientalis-infected erythrocytes. Parasit Vectors. 2018;11:433 pubmed publisher
    ..The spherical body proteins (SBPs) secreted by spherical bodies include SBP1, SBP2, SBP3 and SBP4. Up to now, only SBP3 has been characterized in Babesia orientalis...
  12. Sebio A, Gerger A, Matsusaka S, Yang D, Zhang W, Stremitzer S, et al. Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer. Pharmacogenet Genomics. 2015;25:30-7 pubmed publisher
    ..Nine polymorphisms in eight obesity-related genes (PPAR, LEP, NFKB, CD36, DRG1, NGAL, REGIA, and DSCR1) were evaluated. The primary endpoint of the study was the 3-year recurrence rate...
  13. Valassakis C, Livanos P, Minopetrou M, Haralampidis K, Roussis A. Promoter analysis and functional implications of the selenium binding protein (SBP) gene family in Arabidopsis thaliana. J Plant Physiol. 2018;224-225:19-29 pubmed publisher
    ..We provide evidence that (at least) SBP1 expression is tightly linked to detoxification processes related to oxidative stress, since it is downregulated in ..
  14. Cooke B, Buckingham D, Glenister F, Fernandez K, Bannister L, Marti M, et al. A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. J Cell Biol. 2006;172:899-908 pubmed
    ..Targeted gene disruption of a Maurer's cleft protein, SBP1 (skeleton-binding protein 1), prevented IRBC adhesion because of the loss of PfEMP1 expression on the IRBC surface...
  15. Barouch Bentov R, Neveu G, Xiao F, Beer M, Bekerman E, Schor S, et al. Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment. MBio. 2016;7: pubmed publisher
    ..Finally, ESCRT-III and VPS/VTA1 components are also recruited by HCV proteins to mediate assembly...
  16. Ekoue D, Zaichick S, Valyi Nagy K, PICKLO M, Lacher C, HOSKINS K, et al. Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P). J Trace Elem Med Biol. 2017;39:227-233 pubmed publisher
    ..proteins whose levels have been reported to be responsive to selenium availability, including GPX1, SELENOF and SBP1. There was an association between a polymorphism in the gene for MnSOD and the levels of the encoded protein...
  17. Gee D, Phitayakorn R, Khatri A, Butler K, Mullen J, Petrusa E. A Pilot Study to Gauge Effectiveness of Standardized Patient Scenarios in Assessing General Surgery Milestones. J Surg Educ. 2016;73:e1-e8 pubmed publisher
    ..FAC and CCC scores were statistically equivalent except for Systems-Based Practice 1 (SBP1) and Patient Care 3 (PC3) where CCC scores were significantly higher than FAC...
  18. Chan J, Howell K, Langer C, Maier A, Hasang W, Rogerson S, et al. A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies. Cell Mol Life Sci. 2016;73:4141-58 pubmed publisher
    ..Genetic deletion of the trafficking protein skeleton-binding protein-1 (SBP1), which is involved in trafficking the surface antigen PfEMP1, led to a dramatic reduction in antibody recognition ..
  19. Niikura M, Inoue S, Fukutomi T, Yamagishi J, Asahi H, Kobayashi F. Comparative genomics and proteomic analyses between lethal and nonlethal strains of Plasmodium berghei. Exp Parasitol. 2018;185:1-9 pubmed publisher
    ..a deletion mutation in rhoptry-associated protein (rap) 1, and deletion of rap2/3 and skeleton-binding protein 1 (sbp1), in Pb XAT. RAP1 is required for targeting of RAP2 to the rhoptries...
  20. Ying Q, Ansong E, Diamond A, Yang W. A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1. Int J Mol Sci. 2015;16:27599-608 pubmed publisher
    The concentration of selenium-binding protein1 (SBP1) is often lower in tumors than in the corresponding tissue and lower levels have been associated with poor clinical outcomes...
  21. Diamond A. The subcellular location of selenoproteins and the impact on their function. Nutrients. 2015;7:3938-48 pubmed publisher
    ..of these proteins have been described to reside in two or more cellular compartments, and in the case of GPx-1 and SBP1, interact with each other...
  22. Monroe N, Han H, Shen P, Sundquist W, Hill C. Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. elife. 2017;6: pubmed publisher
    ..We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1, ADP·BeFx, and an ESCRT-III substrate peptide...
  23. Lu L, Lv Y, Dong J, Hu S, Peng R. DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation. Oncotarget. 2016;7:72795-72806 pubmed publisher
    Developmentally regulated GTP binding protein 1 (DRG1), a member of the DRG family, plays important roles in regulating cell growth...
  24. Park M, Cho Y, Lee Y, Jung W. Whole genome sequencing analysis of the cutaneous pathogenic yeast Malassezia restricta and identification of the major lipase expressed on the scalp of patients with dandruff. Mycoses. 2017;60:188-197 pubmed publisher
    ..We found that, among the identified lipase-encoding genes, the gene encoding lipase homolog MRES_03670, named LIP5 in this study, was the most frequently expressed lipase in the swab samples...
  25. Ying Q, Ansong E, Diamond A, Lu Z, Yang W, Bie X. Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways. PLoS ONE. 2015;10:e0126285 pubmed publisher
    Previous studies have shown the tumor-suppressive role of selenium-binding protein 1 (SBP1), but the underlying mechanisms are unclear...
  26. Buono R, Paez Valencia J, Miller N, Goodman K, Spitzer C, Spalding E, et al. Role of SKD1 Regulators LIP5 and IST1-LIKE1 in Endosomal Sorting and Plant Development. Plant Physiol. 2016;171:251-64 pubmed publisher
    ..Its ATPase activity and endosomal recruitment are regulated by the ESCRT components LIP5 and IST1. How LIP5 and IST1 affect ESCRT-mediated endosomal trafficking and development in plants is not known...
  27. Razakamanantsoa A, Djeran Maigre I. Long term chemo-hydro-mechanical behavior of compacted soil bentonite polymer complex submitted to synthetic leachate. Waste Manag. 2016;53:92-104 pubmed publisher
    ..conductivity of prehydrated soil bentonite (SB) and direct permeation of polymer added soil bentonite are studied (SBP1 and SBP2). Hydraulic test duration are in range of 45days to 556days long...
  28. Lee E, Shin Y, Park E, Kim N, Moon A, Kwack S, et al. Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity. Arch Toxicol. 2017;91:1635-1648 pubmed publisher
    ..The corresponding spots were quantitated by RT-PCR. Selenium-binding protein 1 (SBP1) was found to be the most markedly upregulated protein in the kidney cortex of rats after HgCl2 ..
  29. Tan X, Liao L, Wan Y, Li M, Chen S, Mo W, et al. Downregulation of selenium-binding protein 1 is associated with poor prognosis in lung squamous cell carcinoma. World J Surg Oncol. 2016;14:70 pubmed publisher
    We found that selenium-binding protein 1 (SBP1) was progressively decreased in the human bronchial epithelial carcinogenic processes...
  30. Yu Rice Y, Edassery S, Urban N, Hellstrom I, Hellstrom K, Deng Y, et al. Selenium-Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer. Reproduction. 2017;153:277-284 pubmed publisher
    ..The goal was to determine if antibodies to selenium-binding protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and ..
  31. Rehman L, Su X, Guo H, Qi X, Cheng H. Protoplast transformation as a potential platform for exploring gene function in Verticillium dahliae. BMC Biotechnol. 2016;16:57 pubmed publisher
    ..dahliae was also silenced with four siRNAs (siRNA-vta1, siRNA-vta2, siRNA-vta3 and siRNA-vta4) independently and together using the same approach; siRNA-vta1 had the ..
  32. Wang F, Yang Y, Wang Z, Zhou J, Fan B, Chen Z. A Critical Role of Lyst-Interacting Protein5, a Positive Regulator of Multivesicular Body Biogenesis, in Plant Responses to Heat and Salt Stresses. Plant Physiol. 2015;169:497-511 pubmed publisher
    ..We have recently shown that Arabidopsis (Arabidopsis thaliana) Lyst-Interacting Protein5 (LIP5), a positive regulator of the Suppressor of K(+) Transport Growth Defect1 (SKD1) AAA ATPase in MVB biogenesis, is a ..
  33. Guo J, Hu J, Sun Y, Yu L, He J, He P, et al. A novel Babesia orientalis 135-kilodalton spherical body protein like: identification of its secretion into cytoplasm of infected erythrocytes. Parasit Vectors. 2018;11:205 pubmed publisher
    ..Four different SBP homologues (SBP1, SBP2, SBP3 and SBP4) have been identified in Babesia bovis and Babesia bigemina...
  34. Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. Brain Res. 2001;910:29-37 pubmed
    ..Our results have provided a foundation for better understanding of the molecular basis of glial cell functions in dopaminergic transmission and an approach to find possible medication for the related disorders. ..
  35. Otsuka T, Kirkham C, Brauer A, Koszelak Rosenblum M, Malkowski M, Murphy T. The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis. Infect Immun. 2016;84:432-8 pubmed publisher
    ..catarrhalis. In this study, we showed that SBP1, -2, and -3 individually bind different basic amino acids with exquisite specificity...
  36. Guo E, Xu Z. Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains. J Biol Chem. 2015;290:8396-408 pubmed publisher
    ..of the ESCRT-III protein IST1, which binds to the microtubule interacting and trafficking (MIT) domains of VPS4, LIP5, and Spartin via its C-terminal MIT-interacting motif (MIM)...
  37. Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, et al. Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE. Brain Res. 2006;1100:13-20 pubmed
    ..These findings suggest that DRG-1 may contribute to the dopamine-induced cell growth, which is negatively regulated by NADE. ..
  38. Ansong E, Ying Q, Ekoue D, Deaton R, Hall A, Kajdacsy Balla A, et al. Evidence that selenium binding protein 1 is a tumor suppressor in prostate cancer. PLoS ONE. 2015;10:e0127295 pubmed publisher
    Selenium-Binding Protein 1 (SBP1, SELENBP1, hSP56) is a selenium-associated protein shown to be at lower levels in tumors, and its lower levels are frequently predictive of a poor clinical outcome...
  39. Ward D, Vaughn M, Shiflett S, White P, Pollock A, Hill J, et al. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem. 2005;280:10548-55 pubmed
    We examined the function of LIP5 in mammalian cells, because the yeast homologue Vta1p was recently identified as a protein required for multivesicular body (MVB) formation. LIP5 is predominantly a cytosolic protein...
  40. Xia H, Shao D, Liu X, Wang Q, Zhou Y, Chen K. Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development. J Insect Sci. 2017;17: pubmed publisher
    Vps20-associated 1 (Vta1) positively regulates Vacuolar protein sorting 4 (Vps4) to disassemble endosomal sorting complex required for transport III (ESCRT-III) for repeated uses in multivesicular body (MVB) pathway, virus budding and ..
  41. Bajorek M, Morita E, Skalicky J, Morham S, Babst M, Sundquist W. Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell. 2009;20:1360-73 pubmed publisher
    ..1 and Vps4p and exhibits synthetic vacuolar protein sorting defects when combined with mutations in the Vta1p/LIP5-Vps60p/CHMP5 complex...
  42. Boone M, Mobasheri A, Fenton R, van Balkom B, Wismans R, Van der Zee C, et al. The lysosomal trafficking regulator interacting protein-5 localizes mainly in epithelial cells. J Mol Histol. 2010;41:61-74 pubmed publisher
    ..The lysosomal trafficking regulator interacting protein-5 (LIP5) is part of the complex protein machinery involved in MVB biosynthesis...
  43. Shim S, Merrill S, Hanson P. Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. Mol Biol Cell. 2008;19:2661-72 pubmed publisher
    ..VPS4 oligomerization and ATPase activity are promoted by binding to LIP5. LIP5 also binds to the ESCRT-III like protein CHMP5/hVps60, but how this affects its function remains unclear...
  44. Ishida Y, Kayama T, Kibune Y, Nishimoto S, Koike S, Suzuki T, et al. Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress. Biochem Biophys Res Commun. 2017;493:573-577 pubmed publisher
    ..protein was purified from the blood of schizophrenic patients and identified as selenium binding protein 1 (SBP1) by LC-MS/MS...
  45. Davies B, Norgan A, Payne J, Schulz M, Nichols M, TAN J, et al. Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 α7 and α9 to stimulate ATP hydrolysis. J Biol Chem. 2014;289:28707-18 pubmed publisher
    ..The carboxyl-terminal Vta1/SBP-1/Lip5 (VSL) domain of Vta1 binds to the Vps4 β-domain to promote Vps4 oligomerization-dependent ATP hydrolysis...
  46. Roche J, Survery S, Kreida S, Nesverova V, Ampah Korsah H, Gourdon M, et al. Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5. J Biol Chem. 2017;292:14636-14648 pubmed publisher
    ..between the renal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein LIP5 targets AQP2 to multivesicular bodies and facilitates lysosomal degradation...
  47. Agromayor M, Carlton J, Phelan J, Matthews D, Carlin L, Ameer Beg S, et al. Essential role of hIST1 in cytokinesis. Mol Biol Cell. 2009;20:1374-87 pubmed publisher
    ..KIAA0174 as the human homologue of IST1 (hIST1), and we report its conserved interaction with VPS4, CHMP1A/B, and LIP5. We also identify a microtubule interacting and transport (MIT) domain interacting motif (MIM) in hIST1 that is ..
  48. Ma Y, Boucrot E, Villen J, Affar E, Gygi S, Gottlinger H, et al. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem. 2007;282:9805-12 pubmed
  49. Fujita H, Umezuki Y, Imamura K, Ishikawa D, Uchimura S, Nara A, et al. Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. J Cell Sci. 2004;117:2997-3009 pubmed
    ..We have identified two SKD1-binding proteins, SBP1 and mVps2, by yeast two-hybrid screening and we assign them as mammalian class E Vps proteins...
  50. Pincetic A, Kuang Z, Seo E, Leis J. The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process. J Virol. 2010;84:4725-36 pubmed publisher
    ..This is caused by a loss in interaction between Vps4 with its coactivator protein LIP5 needed to promote the formation of the ESCRT-III-Vps4 double-hexamer complex required for membrane scission and ..
  51. Ju S, Tardiff D, Han H, Divya K, Zhong Q, Maquat L, et al. A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol. 2011;9:e1001052 pubmed publisher
    ..over-expression library identified five yeast DNA/RNA binding proteins, encoded by the yeast genes ECM32, NAM8, SBP1, SKO1, and VHR1, that rescue the toxicity of human FUS/TLS without changing its expression level, cytoplasmic ..
  52. Chen L, Chen R, Kemper S, Brigstock D. Pathways of production and delivery of hepatocyte exosomes. J Cell Commun Signal. 2018;12:343-357 pubmed publisher
    ..vesicle trafficking (Rab 5a,b,c, Rab 7a, Rab 27a,b) or exosome biogenesis via the ESCRT (HGS, Alix, STAM1, TSG101, VTA1, YKT6) or ceramide (nSmase2) pathways...
  53. Skalicky J, Arii J, Wenzel D, Stubblefield W, Katsuyama A, Uter N, et al. Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem. 2012;287:43910-26 pubmed publisher
    ..ESCRT-III and VPS4 ATPase complexes catalyze the membrane fission events associated with these processes, and the LIP5 protein helps regulate their interactions by binding directly to a subset of ESCRT-III proteins and to VPS4...
  54. Steffens A, Jakoby M, Hulskamp M. Physical, Functional and Genetic Interactions between the BEACH Domain Protein SPIRRIG and LIP5 and SKD1 and Its Role in Endosomal Trafficking to the Vacuole in Arabidopsis. Front Plant Sci. 2017;8:1969 pubmed publisher
    ..ATPase Suppressor of K+-transport growth defect1 (SKD1) and its positive regulator, LYST Interacting Protein 5 (LIP5) and report genetic interactions between SPI and SKD1 and LIP5...
  55. Vild C, Li Y, Guo E, Liu Y, Xu Z. A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5. J Biol Chem. 2015;290:7291-303 pubmed publisher
    ..reaction is catalyzed by VPS4, an AAA-ATPase whose activity is tightly regulated by a host of proteins, including LIP5 and the ESCRT-III proteins...
  56. Ikram M, Sim X, Xueling S, Jensen R, Cotch M, Hewitt A, et al. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet. 2010;6:e1001184 pubmed publisher
    ..61×10(-25), within the RASIP1 locus), rs225717 (6q24; p = 1.25×10(-16), adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p  =  2...
  57. Tadesse F, Lanke K, Nebie I, Schildkraut J, Gonçalves B, Tiono A, et al. Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial. Am J Trop Med Hyg. 2017;97:188-198 pubmed publisher
    ..In this study, we compared the performance of skeleton-binding protein 1 (SBP1), ring-infected erythrocyte surface antigen, Hyp8, ring-exported protein 1 (REX1), and PHISTb mRNA for detecting ..
  58. Kuang Z, Seo E, Leis J. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. J Virol. 2011;85:7153-61 pubmed publisher
    ..The late block to release is caused in part by a loss in interaction between VPS4 and its coactivator protein LIP5, which is required to promote the formation of the ESCRT III-VPS4 double-hexamer complex to activate its ATPase...
  59. Brandariz Nuñez A, Zeng F, Lam Q, Jin H. Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner. RNA. 2018;24:43-55 pubmed publisher
    RNA-binding protein Sbp1 facilitates the decapping pathway in mRNA metabolism and inhibits global mRNA translation by an unclear mechanism...
  60. Schellhaus A, Moreno Andrés D, Chugh M, Yokoyama H, Moschopoulou A, De S, et al. Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics. Sci Rep. 2017;7:9996 pubmed publisher
    ..We identify here Developmentally regulated GTP binding protein 1 (DRG1) as a microtubule binding protein with diverse microtubule-associated functions...
  61. Scott A, Chung H, Gonciarz Swiatek M, Hill G, Whitby F, Gaspar J, et al. Structural and mechanistic studies of VPS4 proteins. EMBO J. 2005;24:3658-69 pubmed
    ..Human and yeast adaptor proteins (LIP5 and yVta1p, respectively) bound the beta domains of the fully assembled hVPS4B and yVps4p proteins...
  62. Veloudi P, Blizzard C, Srikanth V, Schultz M, Sharman J. Influence of blood pressure level and age on within-visit blood pressure variability in children and adolescents. Eur J Pediatr. 2018;177:205-210 pubmed publisher
    ..BPV was defined as the absolute difference (?SBPABS) between the first (SBP1) and second systolic BP (SBP2) and the overall variability in three measures when available (SBPV)...