Gene Symbol: VPS37C
Description: VPS37C, ESCRT-I subunit
Alias: vacuolar protein sorting-associated protein 37C, ESCRT-I complex subunit VPS37C, hVps37C, vacuolar protein sorting 37 homolog C, vacuolar protein sorting 37C
Stuchell M, Garrus J, Muller B, Stray K, Ghaffarian S, McKinnon R, et al
. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem. 2004;279:36059-71 pubmed
..Taken together, these experiments define new components of the human ESCRT-I complex and characterize several TSG101 protein/protein interactions required for HIV-1 budding and infectivity. ..
Eastman S, Martin Serrano J, Chung W, Zang T, Bieniasz P. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. J Biol Chem. 2005;280:628-36 pubmed
..Using yeast two-hybrid screens, we identified one of a family of human proteins (VPS37C) as a Tsg101-binding protein...
Morita E, Sandrin V, Chung H, Morham S, Gygi S, Rodesch C, et al
. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 2007;26:4215-27 pubmed
..These experiments suggest that the ESCRT pathway may be recruited to facilitate analogous membrane fission events during HIV budding, MVB vesicle formation, and the abscission stage of cytokinesis. ..
Morita E, Sandrin V, Alam S, Eckert D, Gygi S, Sundquist W. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe. 2007;2:41-53 pubmed
..Taken together, these studies define the composition of human ESCRT-I complexes and indicate that the MVB12 subunits play a unique role in regulating ESCRT-mediated virus budding. ..
Stefani F, Zhang L, Taylor S, Donovan J, Rollinson S, Doyotte A, et al
. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Curr Biol. 2011;21:1245-50 pubmed publisher
..UBAP1 is part of a complex that contains a fraction of total cellular TSG101 and that also contains VPS37A but not VPS37C. Hence, the presence of UBAP1, in combination with VPS37A, defines an endosome-specific ESCRT-I complex.
Agromayor M, Soler N, Caballe A, Kueck T, Freund S, Allen M, et al
. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure. 2012;20:414-28 pubmed publisher
Okumura M, Katsuyama A, Shibata H, Maki M. VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I. Biosci Biotechnol Biochem. 2013;77:1715-21 pubmed
..VPS37B and VPS37C appeared to interact with ALG-2 in a stronger manner than TSG101 does...
Wunderley L, Brownhill K, Stefani F, Tabernero L, Woodman P. The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. J Cell Sci. 2014;127:663-72 pubmed publisher
..The biochemical specificity in ESCRT-I assembly is matched by functional specialisation as siRNA-mediated depletion of UBAP1, but not MVB12A and MVB12B, disrupts ubiquitin-dependent sorting at the MVB. ..