Gene Symbol: VPS35
Description: VPS35, retromer complex component
Alias: MEM3, PARK17, vacuolar protein sorting-associated protein 35, hVPS35, maternal-embryonic 3, vacuolar protein sorting 35 homolog
Species: human
Products:     VPS35

Top Publications

  1. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..These results demonstrate that SNX3 is part of an alternative retromer pathway that functionally separates the retrograde transport of Wls from other retromer cargo. ..
  2. Shi H, Rojas R, Bonifacino J, Hurley J. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol. 2006;13:540-8 pubmed
    The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2...
  3. Follett J, Norwood S, Hamilton N, Mohan M, Kovtun O, Tay S, et al. The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic. 2014;15:230-44 pubmed publisher
    The retromer is a trimeric cargo-recognition protein complex composed of Vps26, Vps29 and Vps35 associated with protein trafficking within endosomes...
  4. Scott K, Kabbarah O, Liang M, Ivanova E, Anagnostou V, Wu J, et al. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature. 2009;459:1085-90 pubmed publisher
  5. Franch Marro X, Wendler F, Guidato S, Griffith J, Baena Lopez A, Itasaki N, et al. Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat Cell Biol. 2008;10:170-7 pubmed publisher
    ..Our analysis of a Drosophila mutant in Vps35 show that, instead, the retromer complex is required for efficient progression of Wingless (a Drosophila Wnt) ..
  6. Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan N, von Zastrow M. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011;13:715-21 pubmed publisher
    ..The present results identify a role for retromer in endocytic trafficking of signalling receptors, in regulating a receptor-linked signalling pathway, and in mediating direct endosome-to-plasma membrane traffic. ..
  7. Steinberg F, Gallon M, Winfield M, Thomas E, Bell A, Heesom K, et al. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nat Cell Biol. 2013;15:461-71 pubmed publisher
    ..Our data identify the SNX27-retromer as a major endosomal recycling hub required to maintain cellular nutrient homeostasis. ..
  8. Hierro A, Rojas A, Rojas R, Murthy N, Effantin G, Kajava A, et al. Functional architecture of the retromer cargo-recognition complex. Nature. 2007;449:1063-7 pubmed
    ..Human retromer consists of two smaller complexes: the cargo recognition VPS26-VPS29-VPS35 heterotrimer and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 (ref. 13)...
  9. Sharma M, Ioannidis J, Aasly J, Annesi G, Brice A, Bertram L, et al. A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. J Med Genet. 2012;49:721-6 pubmed publisher
    ..Asp620Asn variant in familial cases also identified it in idiopathic Parkinson disease cases, and thus provides genetic evidence for a role of p.Asp620Asn in Parkinson disease in different populations worldwide. ..

More Information


  1. Zhao X, Nothwehr S, Lara Lemus R, Zhang B, Peter H, Arvan P. Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic. 2007;8:1829-40 pubmed
    ..Yeast Vps35p (yVps35) exhibits similarity to human Vps35 (hVps35), especially in a completely conserved PRLYL motif contained within an amino-terminal domain...
  2. Bi F, Li F, Huang C, Zhou H. Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity. Int J Biol Sci. 2013;9:149-55 pubmed publisher
    ..Recent studies indicate that mutation in the vacuolar protein sorting 35 (vps35) gene segregates with Parkinson's disease in some families, but how mutation in the vps35 gene causes dopaminergic ..
  3. Helfer E, Harbour M, Henriot V, Lakisic G, Sousa Blin C, Volceanov L, et al. Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. Biol Cell. 2013;105:191-207 pubmed publisher
    ..The CSC is composed of three subunits, VPS35, VPS29 and VPS26. FAM21 directly binds the VPS35 subunit of the retromer CSC...
  4. Kerr M, Bennetts J, Simpson F, Thomas E, Flegg C, Gleeson P, et al. A novel mammalian retromer component, Vps26B. Traffic. 2005;6:991-1001 pubmed
    The mammalian retromer protein complex, which consists of three proteins--Vps26, Vps29, and Vps35--in association with members of the sorting nexin family of proteins, has been implicated in the trafficking of receptors and their ligands ..
  5. Verges M, Luton F, Gruber C, Tiemann F, Reinders L, Huang L, et al. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2004;6:763-9 pubmed
    ..Here, we show a function for the mammalian Vps35-Vps29-Vps26 retromer subcomplex in promoting pIgR-pIgA transcytosis.
  6. Braschi E, Goyon V, Zunino R, Mohanty A, Xu L, McBride H. Vps35 mediates vesicle transport between the mitochondria and peroxisomes. Curr Biol. 2010;20:1310-5 pubmed publisher
    ..An unbiased screen shows that Vps35 and Vps26 are found in complex with MAPL, and confocal imaging reveals Vps35 recruitment to mitochondrial vesicles...
  7. Edgar A, Polak J. Human homologues of yeast vacuolar protein sorting 29 and 35. Biochem Biophys Res Commun. 2000;277:622-30 pubmed
    ..The 10.5 kb, 5 exon, VPS29 gene is located on chromosome 12q24 and the 29.6 kb, 17 exon, VPS35 gene is on chromosome 16...
  8. Tabuchi M, Yanatori I, Kawai Y, Kishi F. Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1. J Cell Sci. 2010;123:756-66 pubmed publisher
    ..DMT1-II colocalizes with the Vps35 subunit of the retromer in TfR-positive endosomes...
  9. Popoff V, Mardones G, Bai S, Chambon V, Tenza D, Burgos P, et al. Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes. Traffic. 2009;10:1868-80 pubmed publisher
    ..J Biol Chem 2001;276:7069-7078), but also via the core complex component Vps35. Hrs codistributes at the ultrastructural level with STxB on early endosomes, and interfering with Hrs function ..
  10. Hao Y, Doyle J, Ramanathan S, Gomez T, Jia D, Xu M, et al. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 2013;152:1051-64 pubmed publisher
    ..These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex. ..
  11. Rojas R, Kametaka S, Haft C, Bonifacino J. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol. 2007;27:1112-24 pubmed
    ..Previous studies showed that the mammalian retromer comprises three proteins, named Vps26, Vps29, and Vps35, plus the sorting nexin, SNX1...
  12. Zavodszky E, Seaman M, Moreau K, Jimenez Sanchez M, Breusegem S, Harbour M, et al. Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat Commun. 2014;5:3828 pubmed publisher
    ..b>VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as ..
  13. Vilariño Güell C, Wider C, Ross O, Dachsel J, Kachergus J, Lincoln S, et al. VPS35 mutations in Parkinson disease. Am J Hum Genet. 2011;89:162-7 pubmed publisher
    ..3 years. Exome analysis suggests that an aspartic-acid-to-asparagine mutation within vacuolar protein sorting 35 (VPS35 c.1858G>A; p.Asp620Asn) is the genetic determinant of disease...
  14. Zimprich A, Benet Pages A, Struhal W, Graf E, Eck S, Offman M, et al. A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet. 2011;89:168-75 pubmed publisher
    ..We found a missense mutation, c.1858G>A (p.Asp620Asn), in the VPS35 gene in all seven affected family members who are alive...
  15. Kingston D, Chang H, Ensser A, Lee H, Lee J, Lee S, et al. Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. J Virol. 2011;85:10627-38 pubmed publisher
    ..that the amino-terminal conserved, glutamate-rich sequence of Tip specifically interacts with the retromer subunit Vps35 and that this interaction not only causes the redistribution of Vps35 from the early endosome to the lysosome but ..
  16. Guo J, Sun Q, Lv Z, Yu R, Li K, Zhang Y, et al. VPS35 gene variants are not associated with Parkinson's disease in the mainland Chinese population. Parkinsonism Relat Disord. 2012;18:983-5 pubmed publisher
    b>VPS35 gene mutation has recently been reported in autosomal-dominant, late-onset Parkinson disease (PD). There are no reports regarding the association between VPS35 and Parkinson's disease (PD) in the Chinese population...
  17. Jia D, Gomez T, Billadeau D, Rosen M. Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell. 2012;23:2352-61 pubmed publisher
    ..which contains 21 copies of a novel L-F-[D/E](3-10)-L-F motif, directly interacts with the retromer CSC protein VPS35. Endosomal localization of FAM21 is VPS35 dependent and relies on multivalency of FAM21 repeat elements...
  18. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..These interactions describe fundamental steps in retromer-mediated transport and establish that the spatial organization of the retromer network is a critical element required for efficient retromer-mediated sorting...
  19. Deng H, Gao K, Jankovic J. The VPS35 gene and Parkinson's disease. Mov Disord. 2013;28:569-75 pubmed publisher
    ..Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the ..
  20. George A, Leahy H, Zhou J, Morin P. The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling. Neurobiol Dis. 2007;26:125-33 pubmed
    ..a possible indirect interaction between the LRP6 intracellular domain and vacuolar protein sorting protein 35 (VPS35)...
  21. Arighi C, Hartnell L, Aguilar R, Haft C, Bonifacino J. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 2004;165:123-33 pubmed
    ..Here, we show that the mammalian retromer complex participates in this retrieval pathway. The hVps35 subunit of retromer interacts with the cytosolic domain of the CI-MPR...
  22. Haft C, de la Luz Sierra M, Bafford R, Lesniak M, Barr V, Taylor S. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000;11:4105-16 pubmed
    ..The data suggest a model in which hVps35 serves as the core of a multimeric complex by binding directly to hVps26, hVps29, and SNX1...
  23. Belenkaya T, Wu Y, Tang X, Zhou B, Cheng L, Sharma Y, et al. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev Cell. 2008;14:120-31 pubmed
    ..Here, we have examined a role of Vps35, an essential retromer subunit, in Wnt signaling in Drosophila and mammalian cells...
  24. Verstraeten A, Wauters E, Crosiers D, Meeus B, Corsmit E, Elinck E, et al. Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population. Neurobiol Aging. 2012;33:1844.e11-3 pubmed publisher
    b>VPS35 was recently identified as a novel autosomal dominant gene for Parkinson disease...
  25. Mecozzi V, Berman D, Simoes S, Vetanovetz C, Awal M, Patel V, et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014;10:443-9 pubmed publisher
    ..These findings show that pharmacological chaperones can enhance the function of a multiprotein complex and may have potential therapeutic implications for neurodegenerative diseases. ..
  26. Seaman M, Harbour M, Tattersall D, Read E, Bright N. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci. 2009;122:2371-82 pubmed publisher
    ..Retromer comprises two functional subcomplexes: the cargo-selective subcomplex is a trimer of the VPS35, VPS29, VPS26 proteins, whereas the sorting nexin proteins, Snx1 and Snx2 function to tubulate the endosomal ..
  27. Popovic D, Akutsu M, Novak I, Harper J, Behrends C, Dikic I. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol. 2012;32:1733-44 pubmed publisher
    ..We propose that LC3-interacting Rab GAPs are implicated in the reprogramming of the endocytic trafficking events under starvation-induced autophagy. ..
  28. Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703-17 pubmed publisher
    ..two protein complexes that act together in endosome-to-Golgi retrieval; the cargo-selective complex is a trimer of VPS35, VPS29 and VPS26 that sorts cargo into tubules for retrieval to the Golgi...
  29. Feng S, Streets A, Nesin V, Tran U, Nie H, Onopiuk M, et al. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. J Am Soc Nephrol. 2017;28:2973-2984 pubmed publisher
    ..Knockdown of SNX3 or the core retromer protein VPS35 increased the surface expression of endogenous PC1 and PC2 in vitro and in vivo and increased Wnt-..
  30. Tang F, Liu W, Hu J, Erion J, Ye J, Mei L, et al. VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function. Cell Rep. 2015;12:1631-43 pubmed publisher
    Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD)...
  31. Ishizu N, Yui D, Hebisawa A, Aizawa H, Cui W, Fujita Y, et al. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum Mol Genet. 2016;25:4507-4517 pubmed publisher
    ..sorting 35 gene (VPS35) have been associated with an autosomal dominant form of late-onset Parkinson disease (PARK17), but there has been considerable debate over whether it is caused by a loss- or gain-of-function mechanism and ..
  32. Fukuda M. Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP. Traffic. 2016;17:709-19 pubmed publisher
    ..e. small GTPase Rabs (Rab32, Rab38 and Rab40C), the retromer complex (a sorting nexin dimer, VPS26, VPS29 and VPS35) and R-SNARE VAMP7...
  33. Sudhaman S, Behari M, Govindappa S, Muthane U, Juyal R, Thelma B. VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians. Neurobiol Aging. 2013;34:2442.e1-3 pubmed publisher
    Mutations in 2 genes, vacuolar protein sorting homolog 35 (VPS35) and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), have been recently reported as causal in autosomal dominant Parkinson's disease (PD) among Caucasians...
  34. Vazquez Sanchez S, Bobeldijk S, Dekker M, van Keimpema L, van Weering J. VPS35 depletion does not impair presynaptic structure and function. Sci Rep. 2018;8:2996 pubmed publisher
    ..We assessed the role of retromer by knocking down VPS35, the core subunit of retromer, in primary hippocampal mouse neurons...
  35. Tian Y, Tang F, Sun X, Wen L, Mei L, Tang B, et al. VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation. Mol Brain. 2015;8:70 pubmed publisher
    Vacuolar protein sorting 35 (VPS35), a key component of retromer, plays an important role in endosome-to-Golgi retrieval of membrane proteins...
  36. Berwick D, Harvey K. The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol. 2014;6:3-12 pubmed publisher
    ..These observations have implications for the pathogenesis and treatment of neurodegenerative diseases in general. ..
  37. Domingo A, Klein C. Genetics of Parkinson disease. Handb Clin Neurol. 2018;147:211-227 pubmed publisher
    ..monogenic forms mimic idiopathic PD and are caused by mutations or copy number variations of SNCA, LRRK2, and VPS35. On the other hand, early-onset forms are associated with PARKIN, PINK1, and DJ1 mutations, nominating ..
  38. Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin U, et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet. 2014;23:4621-38 pubmed publisher
    Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD)...
  39. Song P, Trajkovic K, Tsunemi T, Krainc D. Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway. J Neurosci. 2016;36:2425-37 pubmed publisher
    ..of Parkin function led to decreased endosomal tubulation and membrane association of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), as well as decreased mannose 6 phosphate receptor (M6PR), suggesting the impairment ..
  40. Bonifati V. Genetics of Parkinson's disease--state of the art, 2013. Parkinsonism Relat Disord. 2014;20 Suppl 1:S23-8 pubmed publisher
    ..Highly-penetrant mutations in different genes (SNCA, LRRK2, VPS35, Parkin, PINK1, and DJ-1) are known to cause rare monogenic forms of the disease...
  41. Groppelli E, Len A, Granger L, Jolly C. Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions. PLoS Pathog. 2014;10:e1004518 pubmed publisher
    ..retromer-mediated trafficking requires the Env cytoplasmic tail that we show binds directly to retromer components Vps35 and Vps26...
  42. Wang W, Wang X, Fujioka H, Hoppel C, Whone A, Caldwell M, et al. Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nat Med. 2016;22:54-63 pubmed publisher
    ..The VPS35 gene, which encodes a key component of the membrane protein-recycling retromer complex, is the third autosomal-..
  43. Bandrés Ciga S, Mencacci N, Durán R, Barrero F, Escamilla Sevilla F, Morgan S, et al. Analysis of the genetic variability in Parkinson's disease from Southern Spain. Neurobiol Aging. 2016;37:210.e1-210.e5 pubmed publisher
    ..through a next-generation sequencing panel to screen 8 PD-related genes (LRRK2, SNCA, PARKIN, PINK1, DJ-1, VPS35, GBA, and GCH1) in EOPD and FPD groups and direct Sanger sequencing of GBA exons 8-11 and LRRK2 exons 31 and 41 in ..
  44. Kvainickas A, Orgaz A, Nägele H, Diedrich B, Heesom K, Dengjel J, et al. Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50. J Cell Sci. 2017;130:382-395 pubmed publisher
    ..A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs retromer's association with the WASH complex and also with the uncharacterized protein ankyrin-repeat-..
  45. Bourdenx M, Dehay B. What lysosomes actually tell us about Parkinson's disease?. Ageing Res Rev. 2016;32:140-149 pubmed publisher
    ..Finally, we discuss the influence of ageing on lysosomal impairment and PD aetiology and therapeutic strategies targeting lysosomal function. ..
  46. Bugarcic A, Vetter I, Chalmers S, Kinna G, Collins B, Teasdale R. Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biol Int. 2015;39:1299-306 pubmed publisher
    Retromer is a trimeric complex composed of Vps26, Vps29, and Vps35 and has been shown to be involved in trafficking and sorting of transmembrane proteins within the endosome...
  47. Zhang Y, Chen S, Xiao Q, Cao L, Liu J, Rong T, et al. Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease. Parkinsonism Relat Disord. 2012;18:638-40 pubmed publisher
    Vacuolar protein sorting 35 (VPS35) Asp620Asn mutation has been identified in late-onset familial Parkinson's disease (PD) patients of Swiss and Austrian descent as well as sporadic PD patients in the United States...
  48. Gustavsson E, Guella I, Trinh J, Szu Tu C, Rajput A, Rajput A, et al. Genetic variability of the retromer cargo recognition complex in parkinsonism. Mov Disord. 2015;30:580-4 pubmed publisher
    A pathogenic mutation (VPS35 p.D620N) within the retromer complex has been shown to segregate with late-onset Parkinson's disease (PD). Several studies have subsequently detected the mutation in patients with PD and not in controls...
  49. Zhang J, Reiling C, Reinecke J, Prislan I, Marky L, Sorgen P, et al. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Traffic. 2012;13:745-57 pubmed publisher
    ..Overall, our data identify a new interaction between Rank-5 and EHD1, and novel endocytic regulatory roles that include retromer-based transport and secretion. ..
  50. Török R, Zádori D, Török N, Csility Ã, Vécsei L, Klivényi P. An assessment of the frequency of mutations in the GBA and VPS35 genes in Hungarian patients with sporadic Parkinson's disease. Neurosci Lett. 2016;610:135-8 pubmed publisher
    ..been paid to genes of the glucocerebrosidase (GBA) and the vacuolar protein sorting-associated protein 35 (VPS35)...
  51. Kumar K, Weissbach A, Heldmann M, Kasten M, Tunc S, Sue C, et al. Frequency of the D620N mutation in VPS35 in Parkinson disease. Arch Neurol. 2012;69:1360-4 pubmed
    To evaluate the frequency and clinical spectrum of the recently identified p.D620N mutation in the VPS35 gene in Parkinson disease (PD) in an international sample...
  52. McGough I, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom K, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. J Cell Sci. 2014;127:4940-53 pubmed publisher
    ..Here, we have employed quantitative proteomics to define the interactome of human VPS35, the core retromer component...
  53. Gagliardi M, Annesi G, Tarantino P, Nicoletti G, Quattrone A. Frequency of the ASP620ASN mutation in VPS35 and Arg1205His mutation in EIF4G1 in familial Parkinson's disease from South Italy. Neurobiol Aging. 2014;35:2422.e1-2 pubmed publisher
    ..Recently, 2 studies identified the Asp620Asn mutation in the vacuolar protein sorting 35 (VPS35) gene, and the Arg1205His in the eukaryotic translation initiation factor 4 gamma 1 gene (EIF4G1) were reported to ..
  54. Wang W, Ma X, Zhou L, Liu J, Zhu X. A conserved retromer sorting motif is essential for mitochondrial DLP1 recycling by VPS35 in Parkinson's disease model. Hum Mol Genet. 2017;26:781-789 pubmed publisher
    ..b>VPS35 mutations cause autosomal dominant PD and we recently demonstrated that fPD-associated VPS35 mutants can cause ..
  55. Vardarajan B, Bruesegem S, Harbour M, Inzelberg R, FRIEDLAND R, St George Hyslop P, et al. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging. 2012;33:2231.e15-2231.e30 pubmed publisher
    ..These data implicate additional AD risk genes in the retromer pathway and formally demonstrate a direct link between the activity of the retromer complex and the pathogenesis of AD. ..
  56. Abreu G, Valença D, Campos M, da Silva C, Pereira J, Araujo Leite M, et al. Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil. Neurosci Lett. 2016;635:67-70 pubmed publisher
    Amongst Parkinson's disease (PD) genetic factors, mutations in LRRK2, SNCA, VPS35 and GBA genes are recognized causes of PD...
  57. Sullivan C, Jay A, Stack E, Pakaluk M, Wadlinger E, Fine R, et al. Retromer disruption promotes amyloidogenic APP processing. Neurobiol Dis. 2011;43:338-45 pubmed publisher
    ..precursor protein (APP) processing and trafficking as a result of disrupted retromer activity by knockdown of Vps35, a vacuolar sorting protein that is an essential component of the retromer complex...
  58. Randall G, Panis M, Cooper J, Tellinghuisen T, Sukhodolets K, Pfeffer S, et al. Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A. 2007;104:12884-9 pubmed
    ..Our data define 26 host genes that modulate HCV infection and indicate that the requirement for functional RNAi for HCV replication is dominant over any antiviral activity this pathway may exert against HCV. ..
  59. Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
    ..CI-MPR) from endosomes to the trans-Golgi network (TGN), is thought to consist of a cargo-selective VPS26-VPS29-VPS35 trimer and a membrane-deforming subunit of sorting nexin (SNX)-Bin, Amphyphysin, and Rvs (BAR; SNX-BAR) proteins...
  60. Chu J, Pratico D. The retromer complex system in a transgenic mouse model of AD: influence of age. Neurobiol Aging. 2017;52:32-38 pubmed publisher
    ..In this study we assayed the expression levels of the vacuolar sorting protein 35 (VPS35), VPS26, VPS29, and its cargo proteins, cation independent mannose 6-phosphate receptor, sortilin-related receptor ..
  61. Wang C, Niu M, Zhou Z, Zheng X, Zhang L, Tian Y, et al. VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiol Aging. 2016;46:22-31 pubmed publisher
    Vacuolar protein sorting 35 (VPS35) is a retromer complex component regulating membrane protein trafficking and retrieval...
  62. Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
    ..These five proteins (Vps5, Vps17, Vps26, Vps29, and Vps35 in yeast and SNX1/2, SNX5/6, Vps26, Vps29, and Vps35 in mammalian cells) act as a coat for vesicles budding off of ..
  63. Priya A, Kalaidzidis I, Kalaidzidis Y, Lambright D, Datta S. Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35. Traffic. 2015;16:68-84 pubmed publisher
    ..In this study, we developed a FRET-based assay in HeLa cells that demonstrated the interaction of Rab7 with Vps35 and Vps26 in vivo...
  64. Sheerin U, Charlesworth G, Bras J, Guerreiro R, Bhatia K, Foltynie T, et al. Screening for VPS35 mutations in Parkinson's disease. Neurobiol Aging. 2012;33:838.e1-5 pubmed publisher
    Recently 2 groups have independently identified a mutation in the gene 'vacuolar protein sorting 35 homolog' (VPS35 c.1858G>A; p.Asp620Asn) as a possible cause of autosomal dominant Parkinson's disease (PD)...
  65. Wu S, Fagan R, Uttamapinant C, Lifshitz L, Fogarty K, Ting A, et al. The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach. J Neurosci. 2017;37:9438-9452 pubmed publisher
    ..Short hairpin RNA-mediated Vps35 knockdown revealed that DAT endocytic recycling requires intact retromer...
  66. Kalinderi K, Bostantjopoulou S, Katsarou Z, Dimikiotou M, Fidani L. D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population. Neurosci Lett. 2015;606:113-6 pubmed publisher
    Recently, vacuolar protein sorting 35 (VPS35) and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) have been identified as new causal Parkinson's disease (PD) genes, with the VPS35 D620N and EIF4G1 R1205H mutations being ..
  67. Sowada N, Stiller B, Kubisch C. Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans. Biochem Biophys Res Commun. 2016;476:528-533 pubmed publisher
    The Saccharomyces cerevisiae gene VPS35 encodes a component of the retromer complex which is involved in vesicle transport from endosomes to the trans-Golgi network...
  68. Chen Y, Chen K, Song W, Chen X, Cao B, Huang R, et al. VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China. Neurobiol Aging. 2013;34:1709.e7-8 pubmed publisher
    The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial ..
  69. Mingot J, Bohnsack M, Jäkle U, Gorlich D. Exportin 7 defines a novel general nuclear export pathway. EMBO J. 2004;23:3227-36 pubmed
    ..Second, basic residues are critical for Exp7 recruitment. ..
  70. An C, Kim Y, Kim H, Kim S, Yoo N, Lee S. Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability. Hum Pathol. 2012;43:40-7 pubmed publisher
    ..We found that VPS4B, VPS13A, VPS13B, VPS13C, VPS33A, VPS35, VPS37B, VPS37D, VPS41, and VPS54 have mononucleotide repeats in their coding sequences...
  71. Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, et al. VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. FEBS Lett. 2015;589:1430-6 pubmed publisher
    Retromer is a complex of proteins that functions in the endosome-to-Golgi retrieval cargo transport pathway. VPS35 works as the central subunit of retromer to recognize the cargos and binds with VPS29 and VPS26 via distinct domains...