VPS29

Summary

Gene Symbol: VPS29
Description: VPS29, retromer complex component
Alias: DC15, DC7, PEP11, vacuolar protein sorting-associated protein 29, PEP11 homolog, hVPS29, retromer protein, vacuolar protein sorting 29 homolog, vacuolar sorting protein VPS29/PEP11, vesicle protein sorting 29, x 007 protein
Species: human
Products:     VPS29

Top Publications

  1. Seaman M, McCaffery J, Emr S. A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol. 1998;142:665-81 pubmed
    ..Conservation of the yeast retromer complex components in higher eukaryotes suggests an important general role for this complex in endosome-to-Golgi retrieval. ..
  2. Swarbrick J, Shaw D, Chhabra S, Ghai R, Valkov E, Norwood S, et al. VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS ONE. 2011;6:e20420 pubmed publisher
    b>VPS29 is a key component of the cargo-binding core complex of retromer, a protein assembly with diverse roles in transport of receptors within the endosomal system...
  3. Haft C, de la Luz Sierra M, Bafford R, Lesniak M, Barr V, Taylor S. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000;11:4105-16 pubmed
    ..The data suggest a model in which hVps35 serves as the core of a multimeric complex by binding directly to hVps26, hVps29, and SNX1...
  4. Seaman M, Harbour M, Tattersall D, Read E, Bright N. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci. 2009;122:2371-82 pubmed publisher
    ..Retromer comprises two functional subcomplexes: the cargo-selective subcomplex is a trimer of the VPS35, VPS29, VPS26 proteins, whereas the sorting nexin proteins, Snx1 and Snx2 function to tubulate the endosomal membrane...
  5. Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703-17 pubmed publisher
    ..complexes that act together in endosome-to-Golgi retrieval; the cargo-selective complex is a trimer of VPS35, VPS29 and VPS26 that sorts cargo into tubules for retrieval to the Golgi...
  6. Verges M, Luton F, Gruber C, Tiemann F, Reinders L, Huang L, et al. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2004;6:763-9 pubmed
    ..Here, we show a function for the mammalian Vps35-Vps29-Vps26 retromer subcomplex in promoting pIgR-pIgA transcytosis.
  7. Wang D, Guo M, Liang Z, Fan J, Zhu Z, Zang J, et al. Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. J Biol Chem. 2005;280:22962-7 pubmed
    ..The other site is relatively more hydrophilic and may serve as a binding interface with hVps26p, SNX1, or other target proteins. ..
  8. Shi H, Rojas R, Bonifacino J, Hurley J. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol. 2006;13:540-8 pubmed
    The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2...
  9. Hierro A, Rojas A, Rojas R, Murthy N, Effantin G, Kajava A, et al. Functional architecture of the retromer cargo-recognition complex. Nature. 2007;449:1063-7 pubmed
    ..Human retromer consists of two smaller complexes: the cargo recognition VPS26-VPS29-VPS35 heterotrimer and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 (ref. 13)...

More Information

Publications61

  1. Damen E, Krieger E, Nielsen J, Eygensteyn J, van Leeuwen J. The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide. Biochem J. 2006;398:399-409 pubmed
    ..Struct. Mol. Biol. 12, 594-602]. We demonstrate that recombinant hVps29 (human Vps29) displays in vitro phosphatase activity towards a serine-phosphorylated peptide, containing the ..
  2. Rojas R, Kametaka S, Haft C, Bonifacino J. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol. 2007;27:1112-24 pubmed
    ..Previous studies showed that the mammalian retromer comprises three proteins, named Vps26, Vps29, and Vps35, plus the sorting nexin, SNX1...
  3. Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
    ..These interactions describe fundamental steps in retromer-mediated transport and establish that the spatial organization of the retromer network is a critical element required for efficient retromer-mediated sorting...
  4. Popovic D, Dikic I. TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO Rep. 2014;15:392-401 pubmed publisher
    The RabGAP protein TBC1D5 controls cellular endomembrane trafficking processes and binds the retromer subunit VPS29 and the ubiquitin-like protein ATG8 (LC3)...
  5. Pozdnyakov N, Murrey H, Crump C, Pettersson M, Ballard T, am Ende C, et al. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. J Biol Chem. 2013;288:9710-20 pubmed publisher
    ..GSM E2012, but not with acid GSM-1, allosteric GSI BMS-708163, or substrate docking site peptide inhibitor pep11, providing evidence that these compounds have distinct binding sites...
  6. Durand T, Cueff G, Godin B, Valot B, Clement G, Gaude T, et al. Combined Proteomic and Metabolomic Profiling of the Arabidopsis thaliana vps29 Mutant Reveals Pleiotropic Functions of the Retromer in Seed Development. Int J Mol Sci. 2019;20: pubmed publisher
    ..depends on the core retromer subunit composed of the three vacuolar protein sorting (VPS) proteins, namely VPS26, VPS29, and VPS35...
  7. Sachdeva S, Joo H, Tsai J, Jasti B, Li X. A Rational Approach for Creating Peptides Mimicking Antibody Binding. Sci Rep. 2019;9:997 pubmed publisher
    ..The designed peptide, Pep11, bound to EGFR with KD of 252 nM...
  8. Binda C, Nakamura Y, Henley J, Wilkinson K. Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number. Biochem J. 2019;: pubmed publisher
    ..To promote cargo recycling, the core retromer trimer of VPS26, VPS29 and VPS35 recognises cargo either directly, or through an adaptor protein, the most well-characterised of which is ..
  9. García Hernández V, Sánchez Bernal C, Schvartz D, Calvo J, Sanchez J, Sánchez Yagüe J. A tandem mass tag (TMT) proteomic analysis during the early phase of experimental pancreatitis reveals new insights in the disease pathogenesis. J Proteomics. 2018;181:190-200 pubmed publisher
    ..data were verified by immunoblotting of 11 and 7 different soluble or membrane-associated proteins, either novel (VPS29 and MCTS1) or known factors in AP...
  10. Shirakawa M, Ueda H, Shimada T, Kohchi T, Hara Nishimura I. Myrosin cell development is regulated by endocytosis machinery and PIN1 polarity in leaf primordia of Arabidopsis thaliana. Plant Cell. 2014;26:4448-61 pubmed publisher
    ..of vacuolar trafficking factors, including the vacuolar sorting receptor VSR1 and the retromer components VPS29 and VPS35, suggesting that endocytic pathway rather than vacuolar trafficking pathway is important for myrosin ..
  11. Kovtun O, Leneva N, Bykov Y, Ariotti N, Teasdale R, Schaffer M, et al. Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. Nature. 2018;561:561-564 pubmed publisher
    ..Here we describe the structure of the retromer complex (Vps26-Vps29-Vps35) assembled on membrane tubules with the bin/amphiphysin/rvs-domain-containing sorting nexin protein Vps5, ..
  12. Seaman M, Mukadam A, Breusegem S. Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex. J Cell Sci. 2018;131: pubmed publisher
    ..Retromer mediates cargo selection through a trimeric complex comprising VPS35, VPS29 and VPS26, which is recruited to endosomes by binding to Rab7a and Snx3...
  13. Freeman C, Hesketh G, Seaman M. RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci. 2014;127:2053-70 pubmed publisher
    ..Cargo selection is mediated by the VPS35-VPS29-VPS26 trimer, which additionally recruits the WASH complex through VPS35 binding to the WASH complex subunit FAM21...
  14. Helfer E, Harbour M, Henriot V, Lakisic G, Sousa Blin C, Volceanov L, et al. Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. Biol Cell. 2013;105:191-207 pubmed publisher
    ..The CSC is composed of three subunits, VPS35, VPS29 and VPS26. FAM21 directly binds the VPS35 subunit of the retromer CSC...
  15. McMillan K, Gallon M, Jellett A, Clairfeuille T, Tilley F, McGough I, et al. Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. J Cell Biol. 2016;214:389-99 pubmed publisher
    ..The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26. Two of these paralogues, VPS26A and VPS26B, are expressed in humans...
  16. McGarvey J, Xiao K, Bowman S, Mamonova T, Zhang Q, Bisello A, et al. Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. J Biol Chem. 2016;291:10986-1002 pubmed publisher
    ..SNX27 contains a PDZ domain and serves as a cargo selector for the retromer complex. VPS26, VPS29, and VPS35 retromer subunits were isolated with PTHR in endosomes from cells stimulated with PTH...
  17. Vergés M. Retromer in Polarized Protein Transport. Int Rev Cell Mol Biol. 2016;323:129-79 pubmed publisher
    ..It is constituted by a heterotrimer encoded by the vacuolar protein sorting (VPS) gene products Vps26, Vps35, and Vps29, which selects cargo, and a dimer of phosphoinositide-binding sorting nexins, which deforms the membrane...
  18. Ito J, Baba T, Kawasaki J, Nishigaki K. Ancestral Mutations Acquired in Refrex-1, a Restriction Factor against Feline Retroviruses, during its Cooption and Domestication. J Virol. 2016;90:1470-85 pubmed publisher
    ..Refrex-1 is a truncated envelope protein (Env) encoded by both ERV-DC7 and ERV-DC16 proviral loci...
  19. Yao J, Yang F, Sun X, Wang S, Gan N, Liu Q, et al. Mechanism of inhibition of retromer transport by the bacterial effector RidL. Proc Natl Acad Sci U S A. 2018;115:E1446-E1454 pubmed publisher
    ..Here we present the crystal structure of RidL in complex with VPS29, a subunit of the retromer...
  20. Feng S, Streets A, Nesin V, Tran U, Nie H, Onopiuk M, et al. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. J Am Soc Nephrol. 2017;28:2973-2984 pubmed publisher
    ..Knockdown of SNX3 or the core retromer protein VPS35 increased the surface expression of endogenous PC1 and PC2 in vitro and in vivo and ..
  21. Fukuda M. Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP. Traffic. 2016;17:709-19 pubmed publisher
    ..e. small GTPase Rabs (Rab32, Rab38 and Rab40C), the retromer complex (a sorting nexin dimer, VPS26, VPS29 and VPS35) and R-SNARE VAMP7...
  22. Bugarcic A, Vetter I, Chalmers S, Kinna G, Collins B, Teasdale R. Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biol Int. 2015;39:1299-306 pubmed publisher
    Retromer is a trimeric complex composed of Vps26, Vps29, and Vps35 and has been shown to be involved in trafficking and sorting of transmembrane proteins within the endosome...
  23. Stutz C, Reinz E, Honegger A, Bulkescher J, Schweizer J, Zanier K, et al. Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides. PLoS ONE. 2015;10:e0132339 pubmed publisher
    ..The HPV type 16 (HPV16) E6-binding peptide pep11, and variants thereof, induce cell death specifically in HPV16-positive cancer cells...
  24. Maruzs T, Lőrincz P, Szatmári Z, Széplaki S, Sándor Z, Lakatos Z, et al. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic. 2015;16:1088-107 pubmed publisher
    The retromer is an evolutionarily conserved coat complex that consists of Vps26, Vps29, Vps35 and a heterodimer of sorting nexin (Snx) proteins in yeast...
  25. Lagousi T, Routsias J, Piperi C, Tsakris A, Chrousos G, Theodoridou M, et al. Discovery of Immunodominant B Cell Epitopes within Surface Pneumococcal Virulence Proteins in Pediatric Patients with Invasive Pneumococcal Disease. J Biol Chem. 2015;290:27500-10 pubmed publisher
    ..Ten immunodominant B cell epitopes were identified: CbpD-pep4 (amino acids (aa) 291-310), PhtD-pep11 (aa 88-107), PhtD-pep17 (aa 172-191), PhtD-pep19 (aa 200-219), PhtE-pep32 (aa 300-319), PhtE-pep40 (aa 79-98), ..
  26. Iqbal M, Siddiqui A, Alam A, Goyal M, Banerjee C, Sarkar S, et al. Expression, purification and characterization of Plasmodium falciparum vacuolar protein sorting 29. Protein Expr Purif. 2016;120:7-15 pubmed publisher
    ..Plasmodium falciparum VPS29 (PfVPS29) is predicted to be a functional component in the assembly of the retromer complex; however, so far ..
  27. Hsiao J, Chu L, Lo Y, Lee S, Chen T, Huang C, et al. Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22. J Virol. 2015;89:8365-82 pubmed publisher
    ..trafficking events require the important endosome-tethered protein VPEF/FAM21, which recruits WASH and retromer protein complexes to the endosome...
  28. Siddiqa A, Massimi P, Pim D, Broniarczyk J, Banks L. Human Papillomavirus 16 Infection Induces VAP-Dependent Endosomal Tubulation. J Virol. 2018;92: pubmed publisher
    ..prior to localization at the trans-Golgi network, with the incoming virion-transduced DNA accumulating in Vps29/TGN46-positive hybrid vesicles...
  29. Harrison M, Hung C, Liu T, Christiano R, Walther T, Burd C. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014;111:267-72 pubmed publisher
    Retromer is an evolutionarily conserved protein complex composed of the VPS26, VPS29, and VPS35 proteins that selects and packages cargo proteins into transport carriers that export cargo from the endosome...
  30. Romano Moreno M, Rojas A, Williamson C, Gershlick D, Lucas M, Isupov M, et al. Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL. Proc Natl Acad Sci U S A. 2017;114:E11151-E11160 pubmed publisher
    ..The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host scaffold protein VPS29, a component of retromer and retriever complexes critical for endosomal cargo recycling...
  31. Seaman M. Retromer and the CIMPR - time for a trial separation?. Traffic. 2017;: pubmed publisher
    The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR)...
  32. Starble R, POKRYWKA N. The retromer subunit Vps26 mediates Notch signaling during Drosophila oogenesis. Mech Dev. 2018;149:1-8 pubmed publisher
    ..In the current project, we examined the role of the retromer protein Vps26 in oogenesis by characterizing the phenotype of vps26 germline clones...
  33. Edgar A, Polak J. Human homologues of yeast vacuolar protein sorting 29 and 35. Biochem Biophys Res Commun. 2000;277:622-30 pubmed
    ..The 10.5 kb, 5 exon, VPS29 gene is located on chromosome 12q24 and the 29.6 kb, 17 exon, VPS35 gene is on chromosome 16...
  34. Shannon B, Soto Ortolaza A, Rayaprolu S, Cannon H, Labbe C, Benítez B, et al. Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease. Neurobiol Aging. 2014;35:1958.e1-2 pubmed publisher
    ..study we sequenced 702 affected subjects from the Mayo Clinic Parkinson's disease patient-control series for the VPS29 and VPS26A/B genes. We identified only 2 rare nonsynonymous variants in the VPS26A p.K93E and VPS29 p.N72H...
  35. Mecozzi V, Berman D, Simoes S, Vetanovetz C, Awal M, Patel V, et al. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014;10:443-9 pubmed publisher
    ..These findings show that pharmacological chaperones can enhance the function of a multiprotein complex and may have potential therapeutic implications for neurodegenerative diseases. ..
  36. Bärlocher K, Hutter C, Swart A, Steiner B, Welin A, Hohl M, et al. Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5. Nat Commun. 2017;8:1543 pubmed publisher
    ..The effector RidL binds the Vps29 retromer subunit, blocks retrograde vesicle trafficking, and promotes intracellular bacterial replication...
  37. Hesketh G, Pérez Dorado I, Jackson L, Wartosch L, Schäfer I, Gray S, et al. VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface. Dev Cell. 2014;29:591-606 pubmed publisher
    ..We show that recruitment of VARP to the endosomal membrane is mediated by its direct interaction with VPS29, a subunit of the retromer complex, which is involved in trafficking from endosomes to the TGN and the cell ..
  38. McNally K, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat Cell Biol. 2017;19:1214-1225 pubmed publisher
    ..We have called this complex 'retriever'; it is a heterotrimer composed of DSCR3, C16orf62 and VPS29, and bears striking similarity to retromer...
  39. Abubakar Y, Zheng W, Olsson S, Zhou J. Updated Insight into the Physiological and Pathological Roles of the Retromer Complex. Int J Mol Sci. 2017;18: pubmed publisher
    ..In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26-Vps35-Vps29 and a dimer of sorting nexins (SNXs), Vps5-Vps17...
  40. Chu J, Pratico D. The retromer complex system in a transgenic mouse model of AD: influence of age. Neurobiol Aging. 2017;52:32-38 pubmed publisher
    ..In this study we assayed the expression levels of the vacuolar sorting protein 35 (VPS35), VPS26, VPS29, and its cargo proteins, cation independent mannose 6-phosphate receptor, sortilin-related receptor in brains of ..
  41. Follett J, Bugarcic A, Collins B, Teasdale R. Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases. Curr Protein Pept Sci. 2017;18:687-701 pubmed publisher
    The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins - Vps26, Vps29 and Vps35 - that were identified over a decade ago in Saccharomyces cerevisiae (S. cerevisiae)...
  42. Hao Y, Doyle J, Ramanathan S, Gomez T, Jia D, Xu M, et al. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 2013;152:1051-64 pubmed publisher
    ..These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex. ..
  43. Mingot J, Bohnsack M, Jäkle U, Gorlich D. Exportin 7 defines a novel general nuclear export pathway. EMBO J. 2004;23:3227-36 pubmed
    ..Second, basic residues are critical for Exp7 recruitment. ..
  44. Banhart S, Rose L, Aeberhard L, Koch Edelmann S, Heuer D. Chlamydia trachomatis and its interaction with the cellular retromer. Int J Med Microbiol. 2018;308:197-205 pubmed publisher
    ..trafficking hub embedded into the cellular vesicular trafficking pathways recruiting subunits of the retromer protein complex of the host cell...
  45. Zavodszky E, Seaman M, Moreau K, Jimenez Sanchez M, Breusegem S, Harbour M, et al. Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat Commun. 2014;5:3828 pubmed publisher
    ..Thus, the PD-causing D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation. ..
  46. Follett J, Bugarcic A, Yang Z, Ariotti N, Norwood S, Collins B, et al. Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces ?-Synuclein Aggregation. J Biol Chem. 2016;291:18283-98 pubmed publisher
  47. Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, et al. VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. FEBS Lett. 2015;589:1430-6 pubmed publisher
    ..VPS35 works as the central subunit of retromer to recognize the cargos and binds with VPS29 and VPS26 via distinct domains...
  48. Popovic D, Akutsu M, Novak I, Harper J, Behrends C, Dikic I. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol. 2012;32:1733-44 pubmed publisher
    ..Direct binding of the retromer component VPS29 to TBC1D5 could be titrated out by LC3, indicating a molecular switch between endosomes and autophagy...
  49. Cui Y, Yang Z, Teasdale R. The Functional roles of Retromer in Parkinson's disease. FEBS Lett. 2017;: pubmed publisher
    ..Mammalian retromer comprises a core Vps26-Vps35-Vps29 trimer and associates with a range of proteins to generate endosomal tubular-vesicular carriers...
  50. Gustavsson E, Guella I, Trinh J, Szu Tu C, Rajput A, Rajput A, et al. Genetic variability of the retromer cargo recognition complex in parkinsonism. Mov Disord. 2015;30:580-4 pubmed publisher
    ..Mutation screening of the coding regions of the retromer cargo recognition complex genes (VPS26A/B, VPS29, and VPS35) was carried out in patients with PD (n = 396), atypical parkinsonism (n = ..
  51. Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
    ..These five proteins (Vps5, Vps17, Vps26, Vps29, and Vps35 in yeast and SNX1/2, SNX5/6, Vps26, Vps29, and Vps35 in mammalian cells) act as a coat for vesicles ..
  52. Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
    ..CI-MPR) from endosomes to the trans-Golgi network (TGN), is thought to consist of a cargo-selective VPS26-VPS29-VPS35 trimer and a membrane-deforming subunit of sorting nexin (SNX)-Bin, Amphyphysin, and Rvs (BAR; SNX-BAR) ..