Gene Symbol: VPS26B
Description: VPS26, retromer complex component B
Alias: Pep8b, vacuolar protein sorting-associated protein 26B, vesicle protein sorting 26B
McMillan K, Gallon M, Jellett A, Clairfeuille T, Tilley F, McGough I, et al
. Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins. J Cell Biol. 2016;214:389-99 pubmed publisher
..The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26. Two of these paralogues, VPS26A and VPS26B, are expressed in humans...
Bugarcic A, Zhe Y, Kerr M, Griffin J, Collins B, Teasdale R. Vps26A and Vps26B subunits define distinct retromer complexes. Traffic. 2011;12:1759-73 pubmed publisher
..Our group has recently identified a Vps26 paralogue, Vps26B, which is able to suppress the expression of Vps26A when exogenously expressed in mammalian cells and defines a ..
Haft C, de la Luz Sierra M, Bafford R, Lesniak M, Barr V, Taylor S. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell. 2000;11:4105-16 pubmed
..In the absence of hVps35, neither hVps26 nor hVps29 is found in the large complex. These data provide the first insights into the binding interactions among subunits of a putative mammalian retromer complex. ..
Kerr M, Bennetts J, Simpson F, Thomas E, Flegg C, Gleeson P, et al
. A novel mammalian retromer component, Vps26B. Traffic. 2005;6:991-1001 pubmed
..of the mouse genome identified an additional transcribed paralog of the Vps26 retromer protein, which we termed Vps26B. No paralogs were identified for Vps29 and Vps35...
Popovic D, Akutsu M, Novak I, Harper J, Behrends C, Dikic I. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol. 2012;32:1733-44 pubmed publisher
..We propose that LC3-interacting Rab GAPs are implicated in the reprogramming of the endocytic trafficking events under starvation-induced autophagy. ..
Maruzs T, LÅ‘rincz P, SzatmÃ¡ri Z, SzÃ©plaki S, SÃ¡ndor Z, Lakatos Z, et al
. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic. 2015;16:1088-107 pubmed publisher
..Finally, we find that Snx3 and Snx6 are also required for proper autolysosomal degradation in Drosophila larval fat body cells. ..
Trousdale C, Kim K. Retromer: Structure, function, and roles in mammalian disease. Eur J Cell Biol. 2015;94:513-21 pubmed publisher
..Despite the current understanding of the retromer complex, there are still many questions to be answered in regards to its overall role in cell homeostasis. ..
Bugarcic A, Vetter I, Chalmers S, Kinna G, Collins B, Teasdale R. Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biol Int. 2015;39:1299-306 pubmed publisher
..The Vps26 paralog, Vps26B, defines a distinct retromer complex (Vps26B-retromer) in vivo and in vitro...