Gene Symbol: VMP1
Description: vacuole membrane protein 1
Alias: EPG3, TANGO5, TMEM49, vacuole membrane protein 1, ectopic P-granules autophagy protein 3 homolog, transmembrane protein 49, transport and golgi organization 5 homolog
Species: human
Products:     VMP1

Top Publications

  1. Molejón M, Ropolo A, Re A, Boggio V, Vaccaro M. The VMP1-Beclin 1 interaction regulates autophagy induction. Sci Rep. 2013;3:1055 pubmed publisher
    The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases...
  2. Lo Ré A, Fernández Barrena M, Almada L, Mills L, Elsawa S, Lund G, et al. Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells. J Biol Chem. 2012;287:25325-34 pubmed publisher
    ..both in vitro and in vivo evidence of a novel signaling pathway whereby the oncogene KRAS induces the expression of VMP1, a molecule needed for the formation of the authophagosome and capable of inducing autophagy, even under nutrient-..
  3. Grasso D, Ropolo A, Lo Re A, Boggio V, Molejón M, Iovanna J, et al. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. J Biol Chem. 2011;286:8308-24 pubmed publisher
    ..We have coined the term "zymophagy" to refer to this process. The autophagy-related protein VMP1, the ubiquitin-protease USP9x, and the ubiquitin-binding protein p62 mediate zymophagy...
  4. Pardo R, Lo Re A, Archange C, Ropolo A, Papademetrio D, Gonzalez C, et al. Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells. Pancreatology. 2010;10:19-26 pubmed publisher
    ..We have described the vacuole membrane protein-1 (VMP1) whose expression triggers autophagy in mammalian cells...
  5. Yao S, Hu Q, Kerns S, Yan L, Onitilo A, Misleh J, et al. Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study. Clin Epigenetics. 2019;11:45 pubmed publisher
    ..infusions, growth factors, and steroids, changes in four CpGs remained significant, including cg16936953 in VMP1/MIR21, cg01252023 in CORO1B, cg11859398 in SDK1, and cg19956914 in SUMF2...
  6. Murolo S, Romanazzi G. In-vineyard population structure of 'Candidatus Phytoplasma solani' using multilocus sequence typing analysis. Infect Genet Evol. 2015;31:221-30 pubmed publisher
    ..Chardonnay' vineyard, through multilocus sequence typing analysis for the vmp1, stamp and secY genes...
  7. Adams A, Kennedy N, Hansen R, Ventham N, OʼLeary K, Drummond H, et al. Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Inflamm Bowel Dis. 2014;20:1784-93 pubmed publisher
    ..The data strongly implicate known GWAS loci, with compelling evidence implicating MIR21 and the HLA region. ..
  8. Zhao Y, Liu N, Miao G, Chen Y, Zhao H, Zhang H. The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis. Curr Biol. 2018;28:1234-1245.e4 pubmed publisher
    ..VAPs also interact with WIPI2 and enhance the formation of the WIPI2/FIP200 ER/IM tethering complex. Depletion of VMP1, which increases the ER/IM contact, greatly elevates the interaction of VAPs with these autophagy proteins...
  9. Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, et al. Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. J Cell Biol. 2018;217:3817-3828 pubmed publisher
    ..It has a conserved domain also found in vacuole membrane protein 1 (VMP1), another ER multispanning membrane protein essential for autophagy, yeast Tvp38, and the ..

More Information


  1. Blum A, Venkitachalam S, Guo Y, Kieber Emmons A, Ravi L, Chandar A, et al. RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res. 2016;76:5628-5633 pubmed
    ..In particular, we observed RPS6KB1-VMP1 gene fusion as a recurrent event occurring in approximately 10% of esophageal adenocarcinoma cases...
  2. Maiztegui B, Boggio V, Román C, Flores L, Zotto H, Ropolo A, et al. VMP1-related autophagy induced by a fructose-rich diet in ?-cells: its prevention by incretins. Clin Sci (Lond). 2017;131:673-687 pubmed publisher
    ..Serum levels of metabolic/endocrine parameters, ?-cell mass, morphology/ultrastructure and apoptosis, vacuole membrane protein 1 (VMP1) expression and glucose-stimulated insulin secretion (GSIS) were studied...
  3. Imielinski M, Guo G, Meyerson M. Insertions and Deletions Target Lineage-Defining Genes in Human Cancers. Cell. 2017;168:460-472.e14 pubmed publisher
    ..Whole-genome sequencing analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and indel hotspots in surfactant protein genes (SFTPA1, SFTPB, and SFTPC)...
  4. Tábara L, Vicente J, Biazik J, Eskelinen E, Vincent O, Escalante R. Vacuole membrane protein 1 marks endoplasmic reticulum subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution. Traffic. 2018;19:624-638 pubmed publisher
    The multispanning membrane protein vacuole membrane protein 1 (VMP1) marks and regulates endoplasmic reticulum (ER)-domains associated with diverse ER-organelle membrane contact sites...
  5. Nascimbeni A, Giordano F, Dupont N, Grasso D, Vaccaro M, Codogno P, et al. ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis. EMBO J. 2017;36:2018-2033 pubmed publisher
    ..E-Syts are essential for autophagy-associated PI3P synthesis at the cortical ER membrane via the recruitment of VMP1, the stabilizing ER partner of the PI3KC3 complex...
  6. Li S, Chen P, Zheng K, Wang W, Pei Y, Qiu E, et al. ?-Alanine mediated inhibition of PTHR1suppresses the proliferation, invasion and tumorigenesis in metastatic human osteosarcoma U2OS cells. Int J Biol Macromol. 2018;111:1255-1263 pubmed publisher
    ..The mRNA and protein of PTHR1 were reduced in the cells following incubation with ?-alanine. Vacuole membrane protein 1 (Vmp1) mRNA and protein were increased in the cells following incubation with ?-alanine...
  7. Landi L, Riolo P, Murolo S, Romanazzi G, Nardi S, Isidoro N. Genetic Variability of Stolbur Phytoplasma in Hyalesthes obsoletus (Hemiptera: Cixiidae) and its Main Host Plants in Vineyard Agroecosystems. J Econ Entomol. 2015;108:1506-15 pubmed publisher
    ..out using polymerase chain reaction/restriction fragment length polymorphism to investigate the nonribosomal vmp1 gene...
  8. Guo L, Yang L, Fan C, Chen G, Wu F. Novel roles of Vmp1: inhibition metastasis and proliferation of hepatocellular carcinoma. Cancer Sci. 2012;103:2110-9 pubmed publisher
    ..Despite extensive efforts, therapies against metastasis of HCC remain underdeveloped. Vacuole membrane protein 1 (Vmp1) was recently identified to be involved in cancer-relevant processes; however, its expression, ..
  9. Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher
    ..Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts...
  10. Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, et al. miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol. 2008;378:492-504 pubmed publisher
    ..transcribed just downstream from the TATA box in this promoter, which is located in an intron of a coding gene, TMEM49. More important, expression of this overlapping gene is completely PMA-independent and all its transcripts are ..
  11. Loncle C, Molejon M, Lac S, Tellechea J, Lomberk G, Gramatica L, et al. The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. Cell Death Dis. 2016;7:e2295 pubmed publisher
    ..In this study we demonstrate a novel role for vacuole membrane protein 1 (VMP1), a pancreatitis-associated protein critical for inducible autophagy, in the regulation of Kras-..
  12. Qian Q, Zhou H, Chen Y, Shen C, He S, Zhao H, et al. VMP1 related autophagy and apoptosis in colorectal cancer cells: VMP1 regulates cell death. Biochem Biophys Res Commun. 2014;443:1041-7 pubmed publisher
    b>Vacuole membrane protein 1 (VMP1) is an autophagy-related protein and identified as a key regulator of autophagy in recent years. In pancreatic cell lines, VMP1-dependent autophagy has been linked to positive regulation of apoptosis...
  13. Guo X, Ye X, Xiao W, Wei X, You Q, Che X, et al. Downregulation of VMP1 confers aggressive properties to colorectal cancer. Oncol Rep. 2015;34:2557-66 pubmed publisher
    Vacuole membrane protein 1 (VMP1) was recently found to be involved in the process of tumor metastasis and is also considered to play a vital role in balancing apoptosis and autophagy...
  14. Pierro R, Passera A, Panattoni A, Casati P, Luvisi A, Rizzo D, et al. Molecular typing of 'bois noir' phytoplasma strains in the Chianti Classico area (Tuscany, central Italy) and their association with symptom severity in Vitis vinifera L. cv. Sangiovese. Phytopathology. 2017;: pubmed publisher
    ..Nucleotide sequence analyses of vmp1 and stamp genes identified 12 vmp1 and 16 stamp sequence variants, showing an overall positive selection for such ..
  15. Dziuba N, Ferguson M, O Brien W, Sanchez A, Prussia A, McDonald N, et al. Identification of cellular proteins required for replication of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 2012;28:1329-39 pubmed
    ..found to be required for HIV-1 replication, including DHX8, DNAJA1, GTF2E1, GTF2E2, HAP1, KALRN, UBA3, UBE2E3, and VMP1. Candidate genes were independently tested in primary human macrophages, toxicity assays, and/or Tat-dependent ?-..
  16. Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, et al. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology. 2011;54:2064-75 pubmed publisher
    ..We identify vacuole membrane protein 1 (VMP1) as the direct and functional downstream target of miR-210; in addition, we show that its ..
  17. Feng B, Zhu Y, Su Z, Tang L, Sun C, Li C, et al. Basil polysaccharide attenuates hepatocellular carcinoma metastasis in rat by suppressing H3K9me2 histone methylation under hepatic artery ligation-induced hypoxia. Int J Biol Macromol. 2018;107:2171-2179 pubmed publisher
    ..Synchronously, basil polysaccharide could increase E-cadherin and VMP1 expression, and decrease N-cadherin, vimentin and ?-catenin expression...
  18. Liu F, Niu Y, Liu N, Zhang W, Wang S, Liu H, et al. [Expression of vacuole membrane protein 1 and its prognostic value in invasive ductal carcinoma of the breast]. Zhonghua Bing Li Xue Za Zhi. 2013;42:86-9 pubmed publisher
    To investigate the expression of vacuole membrane protein 1 (Vmp1) and its prognostic value in invasive ductal carcinoma (IDC) and concomitant ductal carcinoma in situ (DCIS) of the breast...
  19. Sauermann M, Sahin O, Sultmann H, Hahne F, Blaszkiewicz S, Majety M, et al. Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. Oncogene. 2008;27:1320-6 pubmed
    b>Vacuole membrane protein 1 (Vmp1) is described as a cancer-relevant cell cycle modulator, but the function of this protein and its mode of action in tumor progression are still unknown...
  20. Starkuviene V, Liebel U, Simpson J, Erfle H, Poustka A, Wiemann S, et al. High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic. Genome Res. 2004;14:1948-56 pubmed
    ..It will also serve as an example for similar microscope-based screens addressing different biological questions. ..
  21. Rodriguez M, Catrinacio C, Ropolo A, Rivarola V, Vaccaro M. A novel HIF-1?/VMP1-autophagic pathway induces resistance to photodynamic therapy in colon cancer cells. Photochem Photobiol Sci. 2017;16:1631-1642 pubmed publisher
    ..Our study demonstrates that HIF-1? stabilization significantly increases VMP1-related autophagy through binding to hypoxia responsive elements in the VMP1 promoter...
  22. Zheng L, Chen L, Zhang X, Zhan J, Chen J. TMEM49-related apoptosis and metastasis in ovarian cancer and regulated cell death. Mol Cell Biochem. 2016;416:1-9 pubmed publisher
    Ovarian cancer is one of the greatest causes of cancer death in women. The association of TMEM49 and ovarian cancer is poorly defined...
  23. Dusetti N, Jiang Y, Vaccaro M, Tomasini R, Azizi Samir A, Calvo E, et al. Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation. Biochem Biophys Res Commun. 2002;290:641-9 pubmed
    ..In this report, we describe the cloning, sequencing, and expression pattern of a new gene, named VMP1 (vacuole membrane protein 1). The VMP1 mRNA codes for a putative protein of 406 amino acids...
  24. Gilabert M, Vaccaro M, Fernandez Zapico M, Calvo E, Turrini O, Secq V, et al. Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. J Cell Physiol. 2013;228:1834-43 pubmed publisher
    ..Toward this end, here, we investigated how VMP1, a stress-induced autophagy-associated protein, modulate stress responses triggered by chemotherapeutic agents in ..
  25. Tábara L, Escalante R. VMP1 Establishes ER-Microdomains that Regulate Membrane Contact Sites and Autophagy. PLoS ONE. 2016;11:e0166499 pubmed publisher
    ..Here we describe that VMP1, a multispanning ER-resident protein involved in autophagy, is enriched in ER micro-domains that are in close ..
  26. Ropolo A, Grasso D, Pardo R, Sacchetti M, Archange C, Lo Re A, et al. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem. 2007;282:37124-33 pubmed
    ..We have previously characterized the vacuole membrane protein 1 (VMP1) gene, which is highly activated in acute pancreatitis, a disease associated with morphological ..
  27. Calvo Garrido J, Carilla Latorre S, L zaro Di guez F, Egea G, Escalante R. Vacuole membrane protein 1 is an endoplasmic reticulum protein required for organelle biogenesis, protein secretion, and development. Mol Biol Cell. 2008;19:3442-53 pubmed publisher
    b>Vacuole membrane protein 1 (Vmp1) is membrane protein of unknown molecular function that has been associated with pancreatitis and cancer...
  28. Nowak J, Archange C, Tardivel Lacombe J, Pontarotti P, Pébusque M, Vaccaro M, et al. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell. 2009;20:870-81 pubmed publisher
    ..that TP53INP2 interacts with these proteins, as well as with LC3 and with the autophagosome transmembrane protein VMP1. TP53INP2 translocates from the nucleus to the autophagosome structures after activation of autophagy by rapamycin ..
  29. Chu A, Guilianini F, Grallert H, Dupuis J, Ballantyne C, Barratt B, et al. Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. Circ Cardiovasc Genet. 2012;5:676-85 pubmed publisher
    ..Novel associations were identified and replicated at MS4A4E and TMEM49 for baseline Lp-PLA(2) activity with genome-wide significant joint P values (P=2.0 × 10(-11) and P=2...
  30. Inaki K, Hillmer A, Ukil L, Yao F, Woo X, Vardy L, et al. Transcriptional consequences of genomic structural aberrations in breast cancer. Genome Res. 2011;21:676-87 pubmed publisher
    ..From these candidate gene fusions, we have found a fusion transcript (RPS6KB1-VMP1) recurrently expressed in ?30% of breast cancers associated with potential clinical consequences...
  31. Zhou S, Zhou J, Deng T, Zeng F, Wang Y, Liu X. [Expression and prognostic value of vacuole membrane protein 1 in non-small-cell lung cancer]. Zhonghua Yi Xue Za Zhi. 2011;91:2828-31 pubmed
    To investigate the expression and prognostic value of vacuole membrane protein 1 (VMP1) in non-small-cell lung cancer (NSCLC). The clinical data and survival status of 78 NSCLC patients were collected...