Gene Symbol: VLDLR
Description: very low density lipoprotein receptor
Alias: CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH, very low-density lipoprotein receptor, VLDL receptor
Species: human
Products:     VLDLR

Top Publications

  1. Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, et al. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem. 2008;283:2363-72 pubmed
    ..These include the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) implicated in neuronal development and lipid ..
  2. Argraves K, Battey F, MacCalman C, McCrae K, Gafvels M, Kozarsky K, et al. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes. J Biol Chem. 1995;270:26550-7 pubmed
    ..Ligand blotting experiments using RAP and immunoblotting experiments using an anti-VLDL receptor IgG detected the VLDL receptor in detergent extracts of human aortic endothelial cells, human umbilical vein ..
  3. Webb J, Patel D, Jones M, Knight B, Soutar A. Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA. Hum Mol Genet. 1994;3:531-7 pubmed
    ..It was a minor component in most cell types, but was predominant in Hep G2 cells. ..
  4. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, et al. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999;97:689-701 pubmed
    ..Here, we report the requirement for two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  5. D ARCANGELO G, Homayouni R, Keshvara L, Rice D, Sheldon M, Curran T. Reelin is a ligand for lipoprotein receptors. Neuron. 1999;24:471-9 pubmed
    ..that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Binding requires calcium, and it is inhibited in the presence of apoE...
  6. Benhayon D, Magdaleno S, Curran T. Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Brain Res Mol Brain Res. 2003;112:33-45 pubmed
    Reelin, Disabled-1 (Dab1), apolipoprotein E receptor 2 (ApoER2), and very low density lipoprotein receptor (VLDLR) participate in a signaling pathway required for layer formation during mammalian brain development...
  7. Boycott K, Flavelle S, Bureau A, Glass H, Fujiwara T, Wirrell E, et al. Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. Am J Hum Genet. 2005;77:477-83 pubmed
    ..A 199-kb homozygous deletion encompassing the entire very low density lipoprotein receptor (VLDLR) gene was present in all affected individuals...
  8. Haines J, Schnetz Boutaud N, Schmidt S, Scott W, Agarwal A, Postel E, et al. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci. 2006;47:329-35 pubmed
    ..microsomal glutathione-S-transferase 1 [MGST1], vascular entothelial growth factor [VEGF], and very low density lipoprotein receptor [VLDLR]) were tested for genetic linkage and allelic association, using two independent datasets: ..
  9. Ozcelik T, Akarsu N, Uz E, Caglayan S, Gulsuner S, Onat O, et al. Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. Proc Natl Acad Sci U S A. 2008;105:4232-6 pubmed publisher
    ..3-Mb region of chromosome 9p24. This genomic region includes the VLDLR gene, which encodes the very low-density lipoprotein receptor, a component of the reelin signaling pathway ..

More Information

Publications125 found, 100 shown here

  1. Sakai K, Tiebel O, Ljungberg M, Sullivan M, Lee H, Terashima T, et al. A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins. Brain Res. 2009;1276:11-21 pubmed publisher
    Very-low-density lipoprotein receptor (VLDLR) is a multi ligand apolipoprotein E (apoE) receptor and is involved in brain development through Reelin signaling. Different forms of VLDLR can be generated by alternative splicing...
  2. Takahashi S, Suzuki J, Kohno M, Oida K, Tamai T, Miyabo S, et al. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase. J Biol Chem. 1995;270:15747-54 pubmed
    ..The VLDL receptor binds and internalizes VLDL and intermediate density lipoprotein from Watanabe heritable hyperlipidemic (WHHL) ..
  3. Battey F, Gafvels M, Fitzgerald D, Argraves W, Chappell D, Strauss J, et al. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem. 1994;269:23268-73 pubmed
    ..In cells transfected with the VLDL receptor cDNA, a substantial increase in RAP binding to the 130-kDa polypeptide was noted...
  4. Nakamura Y, Yamamoto M, Kumamaru E. A variant very low density lipoprotein receptor lacking 84 base pairs of O-linked sugar domain in the human brain myelin. Brain Res. 1998;793:47-53 pubmed
    The very low density lipoprotein receptor (VLDLR) was considered to specifically bind to VLDL rich apolipoprotein E (apoE). However, its distribution and functions in vivo have yet to be elucidated...
  5. Hiesberger T, Trommsdorff M, Howell B, Goffinet A, Mumby M, Cooper J, et al. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron. 1999;24:481-9 pubmed
    ..of the Reelin signal by migrating neurons involves two neuronal cell surface proteins, the very low density lipoprotein receptor (VLDLR) and the apoE receptor 2 (ApoER2) as well as a cytosolic adaptor protein, Disabled-1 (Dab1)...
  6. Nakamura Y, Yamamoto M, Kumamaru E. Very low-density lipoprotein receptor in fetal intestine and gastric adenocarcinoma cells. Arch Pathol Lab Med. 2000;124:119-22 pubmed
    A very low-density lipoprotein receptor (VLDLR) was recently identified. This receptor reportedly binds specifically to very low-density lipoproteins; however, its distribution and functions in vivo have yet to be elucidated...
  7. Chen Y, Hu Y, Lu K, Flannery J, Ma J. Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization. J Biol Chem. 2007;282:34420-8 pubmed
    ..b>Very low density lipoprotein receptor gene knock-out (Vldlr(-/-)) mice have been shown to develop subretinal neovascularization (NV) ..
  8. Moheb L, Tzschach A, Garshasbi M, Kahrizi K, Darvish H, Heshmati Y, et al. Identification of a nonsense mutation in the very low-density lipoprotein receptor gene (VLDLR) in an Iranian family with dysequilibrium syndrome. Eur J Hum Genet. 2008;16:270-3 pubmed
    ..2-24.3). The interval contains the VLDLR gene, which codes for the very low-density lipoprotein receptor...
  9. Turkmen S, Hoffmann K, Demirhan O, Aruoba D, Humphrey N, Mundlos S. Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene. Eur J Hum Genet. 2008;16:1070-4 pubmed publisher
    ..of candidate genes identified a homozygous frameshift mutation in the very low-density lipoprotein receptor (VLDLR) gene in all affected individuals...
  10. Akhavan S, Falahatkar B, Ward J, Lokman P. 11-Ketotestosterone induces oocyte growth, but does not affect oocyte cytology in pre-vitellogenic captive beluga, Huso huso L. Comp Biochem Physiol B Biochem Mol Biol. 2019;232:51-59 pubmed publisher
    ..of lipidation-related transcripts [lpl, apolipoprotein E (apoe), very low density lipoprotein receptors (vldlr), low-density lipoprotein receptor-related protein 8-like (lrp8)] was significantly up-regulated after three weeks...
  11. Wassef L, Shete V, Costabile B, Rodas R, Quadro L. High Preformed Vitamin A Intake during Pregnancy Prevents Embryonic Accumulation of Intact β-Carotene from the Maternal Circulation in Mice. J Nutr. 2015;145:1408-14 pubmed publisher
    ..from VA-S + BC dams showed 39% downregulation of LDL-receptor-related protein 1 (Lrp1 ); 35% downregulation of VLDL receptor (Vldlr); 56% reduced mRNA expression of β-carotene 15,15'-oxygenase (Bco1); and 80% upregulation of β-..
  12. Micera A, Balzamino B, Biamonte F, Esposito G, Marino R, Fanelli F, et al. Current progress of Reelin in development, inflammation and tissue remodeling: from nervous to visual systems. Curr Mol Med. 2016;: pubmed
    ..A better understanding of Reelin function in retinal development might open to new attractive perspective for counteracting retina degeneration. ..
  13. Wu J, Strawn T, Luo M, Wang L, Li R, Ren M, et al. Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk. Arterioscler Thromb Vasc Biol. 2015;35:111-20 pubmed publisher
    ..These results broaden our understanding of the roles of PAI-1, vitronectin, and endocytic receptors in regulating VEGFR-2 activation and suggest novel therapeutic strategies for regulating VEGF signaling. ..
  14. Borrell Pagès M, Romero J, Badimon L. LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice. J Cell Mol Med. 2015;19:770-7 pubmed publisher
    ..Three members of the LDLR family, Lrp1, Vldlr and Lrp6, showed up-regulated gene expression levels in aortas of Lrp5(-/-) mice fed a hypercholesterolaemic diet...
  15. Baik M, Lee M, Kang H, Park S, Piao M, Nguyen T, et al. Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet. Eur J Nutr. 2017;56:569-579 pubmed publisher
  16. Fatemi S, Folsom T, Liesch S, Kneeland R, Karkhane Yousefi M, Thuras P. The effects of prenatal H1N1 infection at E16 on FMRP, glutamate, GABA, and reelin signaling systems in developing murine cerebellum. J Neurosci Res. 2017;95:1110-1122 pubmed publisher
    ..Our results provide evidence of disrupted FMRP, glutamatergic, and Reelin signaling in the exposed mouse offspring that explains the multiple brain abnormalities observed in this animal model. © 2016 Wiley Periodicals, Inc...
  17. Xia W, Fouad A, Chen W, Ruan D, Wang S, Fan Q, et al. Estimation of dietary arginine requirements for Longyan laying ducks. Poult Sci. 2017;96:144-150 pubmed
    ..05) as dietary arginine increased. The mRNA abundance of the very low density lipoprotein receptor-b increased in the second large yellow follicle membranes (quadratic, P < 0...
  18. Tavernier A, Davail S, Ricaud K, Bernadet M, Gontier K. Genes involved in the establishment of hepatic steatosis in Muscovy, Pekin and mule ducks. Mol Cell Biochem. 2017;424:147-161 pubmed publisher
    ..Furthermore, similar observations are already described in non-alcoholic fatty liver disease in human, and ask if ducks could be an animal model to study hepatic triglyceride accumulation. ..
  19. Fu Z, Gong Y, Liegl R, Wang Z, Liu C, Meng S, et al. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017;18:1606-1613 pubmed publisher
    ..These data suggest that FGF21 may be a therapeutic target for pathologic vessel growth in patients with neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. ..
  20. Zheng Y. Proteomic analysis of Taenia ovis metacestodes by high performance liquid chromatography-coupled tandem mass spectrometry. Vet Parasitol. 2017;236:113-116 pubmed publisher
    ..Furthermore, comparative analysis of 5 cestodes revealed the presence of Taenia-specific enolases. These data provide clues for better understanding of T. ovis biology, which is informative for effective control of infection. ..
  21. Vauzour D, Rodríguez Ramiro I, Rushbrook S, Ipharraguerre I, Bevan D, Davies S, et al. n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD. Biochim Biophys Acta Mol Basis Dis. 2018;1864:69-78 pubmed publisher
    ..X receptor (Fxr) signalling in the intestine and liver, and hepatic expression of fatty acid transporters (Fabp4, Vldlr, Cd36) were also evident. FLAVn-3 may be a novel intervention for NAFLD...
  22. McKenzie J, Fruttiger M, Abraham S, Lange C, Stone J, Gandhi P, et al. Apelin is required for non-neovascular remodeling in the retina. Am J Pathol. 2012;180:399-409 pubmed publisher
    ..effect in two models of neovascular pathology [laser-induced choroidal neovascularization and the very low density lipoprotein receptor (Vldlr)-knockout mouse]...
  23. Borrell Pages M, Carolina Romero J, Badimon L. LRP5 and plasma cholesterol levels modulate the canonical Wnt pathway in peripheral blood leukocytes. Immunol Cell Biol. 2015;93:653-61 pubmed publisher
    ..Hepatic gene expression of Vldlr, Lrp2 and Lrp6 was increased after HC feeding in WT mice but not in LRP5(-/-) mice, suggesting a role for these ..
  24. Johnson R, Dludla P, Muller C, Huisamen B, Essop M, Louw J. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model. Molecules. 2017;22: pubmed publisher
    ..to modulate key regulators associated with lipid metabolism (Adipoq, Apob, CD36, Cpt1, Pparγ, Srebf1/2, Scd1 and Vldlr), insulin resistance (Igf1, Akt1, Pde3 and Map2k1), inflammation (Il3, Il6, Jak2, Lepr, Socs3, and Tnf13) and ..
  25. Matsui T, Nieto Estévez V, Kyrychenko S, Schneider J, Hsieh J. Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids. Development. 2017;144:1025-1034 pubmed publisher
    ..we observed aberrant Tuj1+ neuronal migration in RB-KO organoids and upregulation of the gene encoding VLDLR, a receptor important in reelin signaling...
  26. Furfari A, Wan B, Ding K, Wong A, Zhu L, Bezjak A, et al. Genetic biomarkers associated with pain flare and dexamethasone response following palliative radiotherapy in patients with painful bone metastases. Ann Palliat Med. 2017;6:S240-S247 pubmed publisher
    ..flare were found in genes with functions in biosynthesis (DHODH, PECR), lipid excretion and metabolism (UGT2A1/2, VLDLR), and intracellular signalling (DNM2, SEC23A)...
  27. Jo D, Lee J, Jun H, Kim J, Wen Q, Hoang M, et al. Gene expression profiles of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. Genet Mol Res. 2015;14:1855-67 pubmed publisher
    ..C57BL/6, Rxrb, Pparbp, Vldlr, and Edf1, which are primarily related to lipid metabolism, were upregulated, while Tgfbr1 and Pdgfb, which are ..
  28. Raza Iqbal S, Tanaka T, Anai M, Inagaki T, Matsumura Y, Ikeda K, et al. Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. J Atheroscler Thromb. 2015;22:754-72 pubmed publisher
    ..Notably, K-877 significantly induces the expression of clinically beneficial target genes (VLDLR, FGF21, ABCA1, MBL2, ENPEP) in human hepatocytes...
  29. Regassa A, Kim W. Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. BMC Genomics. 2015;16:91 pubmed publisher
    ..cellular development (ADORA2B, ATP6VOD2, TNFAIP3), and cell-to-cell signaling and interaction (VCAM1, SPON2, VLDLR)...
  30. Tuong Z, Lau P, Du X, Condon N, Goode J, Oh T, et al. RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages. PLoS ONE. 2016;11:e0147179 pubmed publisher
    ..25HC functions as an inverse agonist for RORα. siRNA knockdown of Ch25h in macrophages up-regulates Vldlr mRNA expression and causes increased accumulation of LDs...
  31. Freitas Ã, Gribble S, Simioni M, Vieira T, Silva Grecco R, Balarin M, et al. Maternally inherited partial monosomy 9p (pter → p24.1) and partial trisomy 20p (pter → p12.1) characterized by microarray comparative genomic hybridization. Am J Med Genet A. 2011;155A:2754-61 pubmed publisher
    ..the phenotype of our patient with those already reported in the literature, and discuss the role of DMRT, DOCK8, FOXD4, VLDLR, RSPO4, AVP, RASSF2, PROKR2, BMP2, MKKS, and JAG1, all genes mapping to the deleted and duplicated regions.
  32. Martin A, Lin M, Granka J, Myrick J, Liu X, Sockell A, et al. An Unexpectedly Complex Architecture for Skin Pigmentation in Africans. Cell. 2017;171:1340-1353.e14 pubmed publisher
    ..this, we identify canonical and non-canonical skin pigmentation loci, including near SLC24A5, TYRP1, SMARCA2/VLDLR, and SNX13, using a genome-wide association approach complemented by targeted resequencing...
  33. Kizhakkedath P, Loregger A, John A, Bleijlevens B, Al Blooshi A, Al Hosani A, et al. Impaired trafficking of the very low density lipoprotein receptor caused by missense mutations associated with dysequilibrium syndrome. Biochim Biophys Acta. 2014;1843:2871-7 pubmed publisher
    ..syndrome type 1 (CAMRQ1) has been attributed to mutations in the VLDLR gene encoding the very low density lipoprotein receptor (VLDLR)...
  34. Yang D, Gao L, Wang T, Qiao Z, Liang Y, Zhang P. Hypoxia triggers endothelial endoplasmic reticulum stress and apoptosis via induction of VLDL receptor. FEBS Lett. 2014;588:4448-56 pubmed
    Endothelial cells express very low density lipoprotein receptor (VLDLr). Beyond the function as peripheral lipoprotein receptor, other roles of VLDLr in endothelial cells have not been completely unraveled...
  35. Kim O, Lee S, Chung J, Do H, Moon J, Shin M. Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity. Nutrition. 2012;28:635-9 pubmed publisher
    ..The mRNA levels of genes (arginase I [ARG1], very low-density lipoprotein receptor [VLDLR], adiponectin receptor-1 [ADIPOR1], ADIPOR2, and nitric oxide synthase-3 [NOS3]) were tested in the subjects' ..
  36. Cheng L, Tian Z, Sun R, Wang Z, Shen J, Shan Z, et al. ApoER2 and VLDLR in the developing human telencephalon. Eur J Paediatr Neurol. 2011;15:361-7 pubmed publisher
    ..Apolipoprotein E receptor type-2 (ApoER2) and very low-density lipoprotein receptor (VLDLR) are canonical receptors of Reelin, through which extracellular Reelin activates the intracellular adapter, ..
  37. Johnson V, Xiang M, Chen Z, Junge H. Neurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant Mice. PLoS ONE. 2015;10:e0132013 pubmed publisher
    ..We use mice with a targeted disruption in the Vldl-receptor (Vldlr) gene as a model to study SRV with retinal origin...
  38. Giorgio E, Ciolfi A, Biamino E, Caputo V, Di Gregorio E, Belligni E, et al. Whole exome sequencing is necessary to clarify ID/DD cases with de novo copy number variants of uncertain significance: Two proof-of-concept examples. Am J Med Genet A. 2016;170:1772-9 pubmed publisher
    ..154T>C (p.Cys52Arg) in the Very Low Density Lipoprotein Receptor (VLDLR)...
  39. Sundelin J, Ståhlman M, Lundqvist A, Levin M, Parini P, Johansson M, et al. Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma. PLoS ONE. 2012;7:e48694 pubmed publisher
    ..These results explain the morphological characteristics of clear-cell RCC, and open up novel possibilities for detection and treatment of clear-cell RCC. ..
  40. Di Donato V, De Santis F, Albadri S, Auer T, Duroure K, Charpentier M, et al. An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System. Neuron. 2018;97:1049-1062.e6 pubmed publisher
    ..arbors in the vertebrate visual system is regulated by a signaling system relying on target-derived Reelin and VLDLR/Dab1a on the projecting neurons...
  41. Nader N, Dib M, Courjaret R, Hodeify R, Machaca R, Graumann J, et al. The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling. J Cell Sci. 2018;131: pubmed publisher
    ..Surprisingly, we identify the very-low-density lipoprotein receptor (VLDLR) as an mPR? (PAQR8) partner that is required for mPR? plasma membrane localization...
  42. Verbrugghe P, Bouwer S, Wiltshire S, Carter K, Chandler D, Cooper M, et al. Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:392-404 pubmed publisher
    ..encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1...
  43. Fu Z, Liegl R, Wang Z, Gong Y, Liu C, Sun Y, et al. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017;58:3862-3870 pubmed publisher
    ..b>Vldlr-/- mice were used to mimic some of the metabolic aspects of AMD...
  44. Lee K, Shin Y, Cheng R, Park K, Hu Y, McBride J, et al. Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling. J Cell Sci. 2014;127:4857-69 pubmed publisher
    ..co-receptor low-density lipoprotein-receptor-related protein 6 (LRP6) and very low-density lipoprotein receptor (VLDLR); the latter belongs to the same protein family as LRP6 and was originally known as a receptor for lipoproteins...
  45. Adam I, Mendoza E, Kobalz U, Wohlgemuth S, Scharff C. FoxP2 directly regulates the reelin receptor VLDLR developmentally and by singing. Mol Cell Neurosci. 2016;74:96-105 pubmed publisher
    ..we show that a lentivirally mediated FoxP2 knockdown in Area X of zebra finches downregulates the expression of VLDLR, one of the two reelin receptors...
  46. Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto T, et al. Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015;523:463-78 pubmed publisher
    ..the formation of the layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR)...
  47. Liu Z, Li H, Li Y, Wang Y, Zong Y, Feng Y, et al. Up-regulation of VLDL receptor expression and its signaling pathway induced by VLDL and beta-VLDL. J Huazhong Univ Sci Technolog Med Sci. 2009;29:1-7 pubmed publisher
    b>Very low density lipoprotein receptor (VLDLR) is thought to participate in the pathogenesis of atherosclerosis induced by VLDL and beta-VLDL...
  48. Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron J, et al. PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. J Lipid Res. 2015;56:2133-42 pubmed publisher
    ..In contrast, in KO female mice, the LDLR is more abundant at the cell surface enterocytes, as is the VLDL receptor (VLDLR) at the cell surface of adipocytes...
  49. Yakovlev S, Medved L. Effect of fibrinogen, fibrin, and fibrin degradation products on transendothelial migration of leukocytes. Thromb Res. 2018;162:93-100 pubmed publisher
    ..Although we have previously proposed that interaction of fibrin with the VLDL receptor (VLDLR) promotes leukocyte transmigration, there is no direct experimental evidence for the involvement of ..
  50. Ujino S, Nishitsuji H, Hishiki T, Sugiyama K, Takaku H, Shimotohno K. Hepatitis C virus utilizes VLDLR as a novel entry pathway. Proc Natl Acad Sci U S A. 2016;113:188-93 pubmed publisher
    ..In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81. Culturing Huh7...
  51. Schulz R, Schluter K. PCSK9 targets important for lipid metabolism. Clin Res Cardiol Suppl. 2017;12:2-11 pubmed publisher
    ..has additional targets which are potentially involved in lipid metabolism regulation such as the very low density lipoprotein receptor (VLDL), CD36 (cluster of differentiation 36) and the epithelial cholesterol transporter (NPC1L1) ..
  52. Cai Z, Li F, Peng C, Li H, Zong Y, Liu Z, et al. Effect of insulin on the differential expression of VLDL receptor isoforms of SGC7901 cell and its biological implication. J Huazhong Univ Sci Technolog Med Sci. 2010;30:551-5 pubmed publisher
    This study examined the effect of insulin on the expression of very low density lipoprotein receptor (VLDLR) subtypes of SGC7901 cells and discussed its biological implication...
  53. Ferri N, Corsini A, Macchi C, Magni P, Ruscica M. Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism: experimental animal models and clinical evidence. Transl Res. 2016;173:19-29 pubmed publisher
    ..2%, respectively. Thus, the understanding of the role of PCSK9 on HDL metabolism needs to be elucidated with a particular focus on the effect of PCSK9 on HDL-mediated reverse cholesterol transport. ..
  54. Au Yeung S, Lam H, Schooling C. Vascular Endothelial Growth Factor and Ischemic Heart Disease Risk: A Mendelian Randomization Study. J Am Heart Assoc. 2017;6: pubmed publisher
    ..i>KCNV2], rs2639990 [ZADH2], rs4782371 [ZFPM1], rs6921438 [LOC100132354], rs7043199 [VLDLR-AS1], rs10761741 [JMJD1C], rs6993770 [ZFPM2], and rs114694170 [MEF2C]), VEGF was ..
  55. Yang D, Zhang P, Wang T, Gao L, Qiao Z, Liang Y, et al. SalA attenuates ischemia/reperfusion-induced endothelial barrier dysfunction via down-regulation of VLDL receptor expression. Cell Physiol Biochem. 2014;33:747-57 pubmed publisher
    Salvianolic acid A (SalA) has been shown to confer robust protection against endothelial injury. VLDL receptor is expressed at high levels on the endothelial surface, however its biological effect on endothelial cells has not yet been ..
  56. Ampuero E, Jury N, Hartel S, Marzolo M, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017;232:1187-1199 pubmed publisher
    ..Extensive evidence shows that reelin via activation of the ApoER2 and VLDLR receptors promotes dendrite and spine formation during early development...
  57. Joyal J, Sun Y, Gantner M, Shao Z, Evans L, Saba N, et al. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016;22:439-45 pubmed publisher
    ..Very-low-density lipoprotein receptor (Vldlr), which is present in photoreceptors and is expressed in other tissues with a high metabolic rate, facilitates the ..
  58. Banerjee Y, Santos R, Al Rasadi K, Rizzo M. Targeting PCSK9 for therapeutic gains: Have we addressed all the concerns?. Atherosclerosis. 2016;248:62-75 pubmed publisher
    ..PCSK9 also enhances the degradation of very-low-density-lipoprotein receptor (VLDLR) and lipoprotein receptor-related protein 1 (LRP-1) in a LDL-receptor independent manner...
  59. Guardiola M, Echeverria P, González M, Vallvé J, Puig J, Clotet B, et al. Polymorphisms in LPL, CETP, and HL protect HIV-infected patients from atherogenic dyslipidemia in an allele-dose-dependent manner. AIDS Res Hum Retroviruses. 2015;31:882-8 pubmed publisher
    ..of 13 polymorphisms of 9 genes affecting lipid metabolism (APOA5, APOC3, LPL, CETP, HL, MTP, APOE, LRP5, and VLDLR genes). The polymorphism rs328 in LPL was 40% significantly more frequent in normolipidemics (p=0...
  60. Menard J, Christianson H, Kucharzewska P, Bourseau Guilmain E, Svensson K, Lindqvist E, et al. Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis. Cancer Res. 2016;76:4828-40 pubmed publisher
    ..in vivo On a mechanistic level, we found no apparent effect of hypoxia on HSPGs, whereas lipoprotein receptors (VLDLR and SR-B1) were transiently upregulated by hypoxia...
  61. Bucher F, Zhang D, Aguilar E, Sakimoto S, Diaz Aguilar S, Rosenfeld M, et al. Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling. Circulation. 2017;136:180-195 pubmed publisher
    ..of retinal neovascular disease, including the mouse model of oxygen-induced retinopathy and the very low density lipoprotein receptor knockout mouse model were analyzed for Tspan/β-catenin regulation...
  62. HOE H, Rebeck G. Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res. 2005;137:31-9 pubmed
    Two brain receptors for apolipoprotein E (apoE), the apoE receptor 2 (apoEr2) and the very low density lipoprotein receptor (VLDLr), are important in neuronal migration during development...
  63. Sundelin J, Lidberg U, Nik A, Carlsson P, Boren J. Hypoxia-induced regulation of the very low density lipoprotein receptor. Biochem Biophys Res Commun. 2013;437:274-9 pubmed publisher
    The very low density lipoprotein receptor (VLDLr) is highly upregulated during hypoxia in mouse cardiomyocytes and in human and mouse ischemic hearts causing a detrimental lipid accumulation...
  64. Weeber E, Beffert U, Jones C, Christian J, Forster E, Sweatt J, et al. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem. 2002;277:39944-52 pubmed
    ..Mice lacking either the VLDL receptor or the apoER2 show contextual fear conditioning deficits...
  65. Zhang G, Assadi A, McNeil R, Beffert U, Wynshaw Boris A, Herz J, et al. The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE. 2007;2:e252 pubmed
    ..structures of the brain through the activation of two receptors, the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2), and the phosphorylation of Disabled-1 (Dab1)...
  66. Lane Donovan C, Philips G, Wasser C, Durakoglugil M, Masiulis I, Upadhaya A, et al. Reelin protects against amyloid β toxicity in vivo. Sci Signal. 2015;8:ra67 pubmed publisher
    ..by binding to the multifunctional ApoE receptors apolipoprotein E receptor 2 (Apoer2) and very low density lipoprotein receptor (Vldlr)...
  67. Okoro E, Zhang H, Guo Z, Yang F, Smith C, Yang H. A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages. PLoS ONE. 2015;10:e0136895 pubmed publisher
    Activation of apolipoprotein E receptor-2 (apoER2) and very low density lipoprotein receptor (VLDLR) inhibits foam cell formation. Reelin is a ligand of these receptors...
  68. Mihail A, Coman G, Staniceanu F, Coman L, Zurac S, Coman O. Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi. J Med Life. 2017;10:85-89 pubmed
    ..b>Abbreviations: ApoER2 = apolipoprotein receptor 2, VLDLR = very low density lipoprotein receptor, DAB-1 = DIABLO protein, HMB45 = gene HMB45.
  69. Chen Y, Troutt J, Konrad R. PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day. Lipids. 2014;49:445-55 pubmed
    ..Our results indicate that regulation of PCSK9 in human CSF may be different than for plasma PCSK9, suggesting that further study of the role of PCSK9 in the CNS is warranted. ..
  70. Micalizzi A, Moroni I, Ginevrino M, Biagini T, Mazza T, Romani M, et al. Very mild features of dysequilibrium syndrome associated with a novel VLDLR missense mutation. Neurogenetics. 2016;17:191-5 pubmed publisher
    ..Recessive loss-of-function mutations in the very low density lipoprotein receptor (VLDLR) gene represent the most common cause of DES...
  71. Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, et al. The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. EMBO J. 2002;21:4259-67 pubmed
    ..to the intracellular domain of some members of the low-density lipoprotein receptor (LDLR) family such as LDLR, VLDLR, ApoER2 and LDLR-related protein...
  72. Seidah N, Abifadel M, Prost S, Boileau C, Prat A. The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9. Pharmacol Rev. 2017;69:33-52 pubmed
    ..itself once, and the secreted inactive protease drags the low-density lipoprotein receptors (LDLR) and very LDLR (VLDLR) to endosomal/lysosomal degradation...
  73. Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock H, Maritzen T, et al. Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2017;114:5533-5538 pubmed publisher
    ..Reelin signals via the lipoprotein receptors very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), but the exact mechanism by which these receptors ..
  74. Gafvels M, Caird M, Britt D, Jackson C, Patterson D, Strauss J. Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23. Somat Cell Mol Genet. 1993;19:557-69 pubmed
  75. Calvo D, Gomez Coronado D, Suarez Y, Lasuncion M, Vega M. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J Lipid Res. 1998;39:777-88 pubmed
  76. Webb D, Thomas K, Gonias S. Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth. J Cell Biol. 2001;152:741-52 pubmed
    ..This effect required the cooperative function of uPAR and the very low density lipoprotein receptor (VLDLr)...
  77. Benes P, Muzik J, Benedik J, Znojil V, Vacha J. The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. Hum Biol. 2002;74:129-36 pubmed
    ..as well as the C766T low-density lipoprotein receptor-related protein (LRP) and the (CGG)n very low density lipoprotein receptor (VLDLR) polymorphisms on the one hand, and plasma Lp(a) levels in Czech subjects who underwent ..
  78. Neumann E, Moser R, Snyers L, Blaas D, Hewat E. A cellular receptor of human rhinovirus type 2, the very-low-density lipoprotein receptor, binds to two neighboring proteins of the viral capsid. J Virol. 2003;77:8504-11 pubmed
    ..When the receptor is bound to neighboring sites on HRV2, steric hindrance prevents binding of the second repeat. ..
  79. Gosselet F, Candela P, Sevin E, Berezowski V, Cecchelli R, Fenart L. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. Brain Res. 2009;1249:34-42 pubmed publisher
    ..ABC transporters (ABCA1, 2, 3, 7 and ABCG1) and low density lipoprotein receptor (LDLR)-related receptors (LDLR, vLDLR, LRP1, LRP2 and LRP8) in BBB endothelium using an in vitro co-culture model of bovine brain capillary endothelial ..
  80. Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, et al. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem. 2010;285:19720-6 pubmed publisher
    ..Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism...
  81. Di Y, Liu Z, Tian J, Zong Y, Yang P, Qu S. TFPI or uPA-PAI-1 complex affect cell function through expression variation of type II very low density lipoprotein receptor. FEBS Lett. 2010;584:3469-73 pubmed publisher
    Very low density lipoprotein receptors (VLDLR) including type I and type II are known to affect cell functions by binding to its extracellular ligands. However, the effect of these ligands on VLDLR expression remains elusive...
  82. He L, Lu Y, Wang P, Zhang J, Yin C, Qu S. Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to ?-catenin in different cancers. BMC Cancer. 2010;10:601 pubmed publisher
    b>Very low density lipoprotein receptor (VLDLR) has been considered as a multiple function receptor due to binding numerous ligands, causing endocytosis and regulating cellular signaling...
  83. Sonmez F, Gleeson J, Celep F, Kul S. The very low density lipoprotein receptor-associated pontocerebellar hypoplasia and dysmorphic features in three Turkish patients. J Child Neurol. 2013;28:379-83 pubmed publisher
    ..The very low density lipoprotein receptor protein is an integral part of the reelin signaling pathway, which guides neuroblast migration in ..
  84. Böttner M, Ghorbani P, Harde J, Barrenschee M, Hellwig I, Vogel I, et al. Expression and regulation of reelin and its receptors in the enteric nervous system. Mol Cell Neurosci. 2014;61:23-33 pubmed publisher
    ..The time course of reelin expression was monitored in an ontogenetic study of rat intestines as well as in GDNF-treated cultures of enteric neurons. ..
  85. Takahashi K, Yan I, Wood J, Haga H, Patel T. Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res. 2014;12:1377-87 pubmed publisher
    ..Of these, lincRNA-VLDLR (linc-VLDLR) was significantly upregulated in malignant hepatocytes...
  86. Valence S, Garel C, Barth M, Toutain A, Paris C, Amsallem D, et al. RELN and VLDLR mutations underlie two distinguishable clinico-radiological phenotypes. Clin Genet. 2016;90:545-549 pubmed publisher
    ..The four other patients had a milder phenotype consistent with CARMQ1 (cerebellar ataxia and mental retardation with or without quadrupedal locomotion)...
  87. Kim B, Yoo H, Lee A, Choi K, Yoon S. Decreased expression of VLDLR is inversely correlated with miR-200c in human colorectal cancer. Mol Carcinog. 2017;56:1620-1629 pubmed publisher
    ..Very-low-density-lipoprotein receptor (VLDLR), a member of the low-density-lipoprotein receptor (LDLR) superfamily, is a multifunctional receptor that ..
  88. Yakovlev S, Medved L. Interaction of Fibrin with the Very Low-Density Lipoprotein (VLDL) Receptor: Further Characterization and Localization of the VLDL Receptor-Binding Site in Fibrin ?N-Domains. Biochemistry. 2017;56:2518-2528 pubmed publisher
    ..The results obtained suggest that interaction between fibrin and the VLDL receptor employs the "double-Lys/Arg" recognition mode previously proposed for the interaction of the LDL receptor ..
  89. Romagnuolo R, Scipione C, Marcovina S, Gemin M, Seidah N, Boffa M, et al. Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9. PLoS ONE. 2017;12:e0180869 pubmed publisher
    ..Finally, we showed that very low density lipoprotein receptor (VLDLR), LDR-related protein (LRP)-8, and LRP-1 do not play a role in Lp(a) internalization or the ..
  90. Yang J, Liu X, Wang D, Ning C, Wang H, Zhang Q, et al. Functional validation of GPIHBP1 and identification of a functional mutation in GPIHBP1 for milk fat traits in dairy cattle. Sci Rep. 2017;7:8546 pubmed publisher
    ..The results showed that the expression of several important milk fat-related genes (LPL, CD36, VLDLR, ACACA and FASN) increased or decreased when the expression of GPIHBP1 was up- or down-regulated...
  91. Sakai J, Hoshino A, Takahashi S, Miura Y, Ishii H, Suzuki H, et al. Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem. 1994;269:2173-82 pubmed
    ..The human VLDL receptor gene contains 19 exons spanning approximately 40 kilobases...