vitamin D binding protein


Gene Symbol: vitamin D binding protein
Description: GC, vitamin D binding protein
Alias: DBP, DBP-maf, DBP/GC, GRD3, Gc-MAF, GcMAF, HEL-S-51, VDB, VDBG, VDBP, vitamin D-binding protein, epididymis secretory protein Li 51, gc protein-derived macrophage activating factor, gc-globulin, group-specific component (vitamin D binding protein), vitamin D-binding alpha-globulin, vitamin D-binding protein-macrophage activating factor
Species: human
Products:     vitamin D binding protein

Top Publications

  1. Shen L, Zhang X, Su D, Yao S, Yu B, Wang H, et al. Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease. J Int Med Res. 2010;38:1093-8 pubmed
    ..Genetic polymorphism of the vitamin-D-binding protein (VDBP) gene is considered one of the candidates for variation in susceptibility to COPD...
  2. Kidd L, Paltoo D, Wang S, Chen W, Akereyeni F, Isaacs W, et al. Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk. Prostate. 2005;64:272-82 pubmed
    The vitamin D receptor (VDR) and binding protein (DBP) mediate the cellular transport, activity, and anti-tumor action of 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D3]...
  3. Korytina G, Akhmadishina L, Ianbaeva D, Viktorova T. [Genotypes of vitamin-D-binding protein (DBP) in patients with chronic obstructive pulmonary disease and healthy population of Republic Bashkortostan]. Mol Biol (Mosk). 2006;40:231-8 pubmed
    The distribution of alleles and genotypes of vitamin D-binding protein (DBP) gene has been studied in patients with Chronic Obstructive Pulmonary Disease (COPD, n = 298) and healthy individuals (n = 237) from two ethnic groups (Tatars ..
  4. Fang Y, van Meurs J, Arp P, van Leeuwen J, Hofman A, Pols H, et al. Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int. 2009;85:85-93 pubmed publisher
    ..As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to ..
  5. Kew R, Sibug M, Liuzzo J, Webster R. Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophils. Blood. 1993;82:274-83 pubmed
    Plasma-derived vitamin D binding protein (DBP) is an important physiologic regulator of the neutrophil chemotactic response to activated complement. A cell-associated form of DBP has been observed in numerous cell types...
  6. Witke W, Gibbs P, Zielinski R, Yang F, Bowman B, Dugaiczyk A. Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family. Genomics. 1993;16:751-4 pubmed
    ..Although the mRNA and protein expressed from the Gc gene are significantly smaller, the gene itself is about 2.5 times larger than the other genes of the family.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  7. Ezura Y, Nakajima T, Kajita M, Ishida R, Inoue S, Yoshida H, et al. Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density. J Bone Miner Res. 2003;18:1642-9 pubmed
    Possible contribution of vitamin D-binding protein (DBP) gene for determination of BMD was tested by characterizing 13 SNPs in 384 adult Japanese women...
  8. Vu D, Sakharkar P, Tellez Corrales E, Shah T, Hutchinson I, Min D. Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients. Mol Biol Rep. 2013;40:933-9 pubmed publisher
    Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant ..
  9. Weinstein S, Stolzenberg Solomon R, Kopp W, Rager H, Virtamo J, Albanes D. Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: a nested case-control study. Cancer Res. 2012;72:1190-8 pubmed publisher contrary to an expected inverse association between vitamin D status and cancer, we examined whether vitamin D binding protein (DBP), the primary carrier of vitamin D compounds in circulation, plays a role in this relationship...

More Information


  1. Hibler E, Hu C, Jurutka P, Martinez M, Jacobs E. Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia. Cancer Epidemiol Biomarkers Prev. 2012;21:368-75 pubmed publisher
    ..Additional research is warranted to determine the mechanism of GC genotype in influencing 25(OH)D concentrations and to further elucidate the role of CASR in colorectal neoplasia. ..
  2. Ravnsborg T, Olsen D, Thysen A, Christiansen M, Houen G, Højrup P. The glycosylation and characterization of the candidate Gc macrophage activating factor. Biochim Biophys Acta. 2010;1804:909-17 pubmed publisher
    The vitamin D binding protein, Gc globulin, has in recent years received some attention for its role as precursor for the extremely potent macrophage activating factor (GcMAF)...
  3. Braun A, Kofler A, Morawietz S, Cleve H. Sequence and organization of the human vitamin D-binding protein gene. Biochim Biophys Acta. 1993;1216:385-94 pubmed
    The structure and organization of the human vitamin D-binding protein (DBP) gene has been determined. The gene is composed of 13 exons and 12 intervening sequences...
  4. Larcombe L, Mookherjee N, Slater J, Slivinski C, Singer M, Whaley C, et al. Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. PLoS ONE. 2012;7:e49872 pubmed publisher
    ..Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases...
  5. Sinotte M, Diorio C, Bérubé S, Pollak M, Brisson J. Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr. 2009;89:634-40 pubmed publisher
    ..b>Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide ..
  6. Ye W, Dubois Laforgue D, Bellanne Chantelot C, Timsit J, Velho G. Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians. Metabolism. 2001;50:366-9 pubmed
    Electrophoretic variants of the vitamin D-binding protein (DBP) have been reported to be associated with type 2 diabetes mellitus (DM) or with prediabetic phenotypes in several non-Caucasian populations...
  7. Pani M, Regulla K, Segni M, Hofmann S, Hufner M, Pasquino A, et al. A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. J Clin Endocrinol Metab. 2002;87:2564-7 pubmed
    ..The polymorphic vitamin D-binding protein (DBP) greatly facilitates vitamin D actions, and DBP alleles differ regarding their affinity for 1,25(OH)(2) D(3)...
  8. Ito I, Nagai S, Hoshino Y, Muro S, Hirai T, Tsukino M, et al. Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele. Chest. 2004;125:63-70 pubmed
    ..01), and lower mean CT score than patients without this allele (p = 0.03). Gc-globulin polymorphism is significantly associated with susceptibility to COPD, and also with the severity of the disease. ..
  9. Laufs J, Andrason H, Sigvaldason A, Halapi E, Thorsteinsson L, Jonasson K, et al. Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. Am J Pharmacogenomics. 2004;4:63-8 pubmed
    Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC*2 and GC*1F, as possible contributors with chronic obstructive pulmonary ..
  10. Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss E, Flesch Janys D, et al. The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev. 2008;17:1339-43 pubmed publisher
    ..The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-..
  11. Engelman C, Fingerlin T, Langefeld C, Hicks P, Rich S, Wagenknecht L, et al. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008;93:3381-8 pubmed publisher
    ..After adjusting for gender and age within the site, two single nucleotide polymorphisms (SNPs) in the vitamin D binding protein gene (DBP), rs4588 and rs7041, were associated with 25(OH)D, and one SNP in the DBP, rs4588, was ..
  12. Lu M, Yang B, Cai Y. [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi. 2004;43:117-20 pubmed
    To determine the association between vitamin D binding protein (VDBP) gene and chronic obstructive pulmonary disease (COPD) susceptibility in Han Nationality in China. This was a case-control study...
  13. Yang F, Brune J, Naylor S, Cupples R, Naberhaus K, Bowman B. Human group-specific component (Gc) is a member of the albumin family. Proc Natl Acad Sci U S A. 1985;82:7994-8 pubmed
    ..Gc cDNA was used as a probe in Southern blot analysis of somatic-cell hybrids to confirm that the Gc locus is on chromosome 4. ..
  14. Jørgensen C, Christiansen M, Nørgaard Pedersen B, Ostergaard E, Schiødt F, Laursen I, et al. Gc globulin (vitamin D-binding protein) levels: an inhibition ELISA assay for determination of the total concentration of Gc globulin in plasma and serum. Scand J Clin Lab Invest. 2004;64:157-66 pubmed
    b>Gc globulin, also called vitamin D-binding protein, is a plasma protein involved in the actin-scavenger system...
  15. Dusso A, Brown A, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8-28 pubmed
    ..This local production of 1,25(OH)(2)D(3) is dependent on circulating precursor levels, providing a potential explanation for the association of vitamin D deficiency with various cancers and autoimmune diseases. ..
  16. Nykjaer A, Fyfe J, Kozyraki R, Leheste J, Jacobsen C, Nielsen M, et al. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Proc Natl Acad Sci U S A. 2001;98:13895-900 pubmed
    ..This observation identifies spontaneous mutations in an endocytic receptor pathway affecting cellular uptake and metabolism of a steroid hormone. ..
  17. Ahn J, Albanes D, Berndt S, Peters U, Chatterjee N, Freedman N, et al. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis. 2009;30:769-76 pubmed publisher
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status. ..
  18. Ahn J, Yu K, Stolzenberg Solomon R, Simon K, McCullough M, Gallicchio L, et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet. 2010;19:2739-45 pubmed publisher
    ..8x10(-49)), NADSYN1/DHCR7 (P=3.4x10(-9)) and CYP2R1 (P=2.9x10(-17)), but not C10orf88 (P=2.4x10(-5)). ..
  19. Wjst M, Altmuller J, Faus Kessler T, Braig C, Bahnweg M, André E. Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir Res. 2006;7:60 pubmed
  20. Wang T, Zhang F, Richards J, Kestenbaum B, van Meurs J, Berry D, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010;376:180-8 pubmed publisher
    ..Genetic variation at these loci identifies individuals who have substantially raised risk of vitamin D insufficiency. Full funding sources listed at end of paper (see Acknowledgments). ..
  21. Chun R, Peercy B, Adams J, Hewison M. Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling. PLoS ONE. 2012;7:e30773 pubmed publisher
    b>Vitamin D binding protein (DBP) plays a key role in the bioavailability of active 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and its precursor 25-hydroxyvitamin D (25OHD), but accurate analysis of DBP-bound and free 25OHD and 1,25(OH)(2)D is ..
  22. Fu L, Yun F, Oczak M, Wong B, Vieth R, Cole D. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem. 2009;42:1174-7 pubmed publisher
    To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year...
  23. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C. A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol. 2002;9:131-6 pubmed
    The human serum vitamin D-binding protein (DBP) has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune ..
  24. Cooke N, David E. Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family. J Clin Invest. 1985;76:2420-4 pubmed
    ..Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family.
  25. McGrath J, Saha S, Burne T, Eyles D. A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol. 2010;121:471-7 pubmed publisher
    ..We found nine studies related to the vitamin D binding protein (group-specific component, GC), and five studies examining the vitamin D receptor (VDR)...
  26. Otterbein L, Cosio C, Graceffa P, Dominguez R. Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system. Proc Natl Acad Sci U S A. 2002;99:8003-8 pubmed
    ..In the second phase, the vitamin D-binding protein (DBP) traps the actin monomers, which accelerates their clearance...
  27. Powe C, Ricciardi C, Berg A, Erdenesanaa D, Collerone G, Ankers E, et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011;26:1609-16 pubmed publisher
    ..Vitamin D-binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D...
  28. Disanto G, Ramagopalan S, Para A, Handunnetthi L. The emerging role of vitamin D binding protein in multiple sclerosis. J Neurol. 2011;258:353-8 pubmed publisher
    ..A growing body of evidence supports a role for vitamin D in MS aetiology. Vitamin D binding protein (DBP) is the major plasma carrier of vitamin D metabolites and genetic differences in DBP gene have been ..
  29. Al oanzi Z, Tuck S, Mastana S, Summers G, Cook D, Francis R, et al. Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men. Osteoporos Int. 2008;19:951-60 pubmed
    ..Vitamin D-binding protein (DBP) plays a critical role in the transport and metabolism of metabolites of vitamin D, including the key calciotropic ..
  30. Zhang J, Kew R. Identification of a region in the vitamin D-binding protein that mediates its C5a chemotactic cofactor function. J Biol Chem. 2004;279:53282-7 pubmed
    The vitamin D-binding protein (DBP), also known as group-specific component or Gc-globulin, is a multifunctional plasma protein that can significantly enhance the leukocyte chemotactic activity to C5a and C5a des-Arg...
  31. Borges C, Jarvis J, Oran P, Nelson R. Population studies of Vitamin D Binding Protein microheterogeneity by mass spectrometry lead to characterization of its genotype-dependent O-glycosylation patterns. J Proteome Res. 2008;7:4143-53 pubmed publisher
    ..the genotype-dependent glycosylation patterns for each of the three major allele products of Vitamin D Binding Protein found in the general human population...
  32. Zhang Y, Wang X, Liu Y, Qu H, Qu S, Wang W, et al. The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children. Swiss Med Wkly. 2012;142:w13636 pubmed publisher
    ..This population-based study was the first to confirm the strong effects of the GC, CYP2R1 and DHCR7/NADSYN1 loci on circulating 25(OH)D concentrations in northeastern Han Chinese children. ..
  33. Bu F, Armas L, Lappe J, Zhou Y, Gao G, Wang H, et al. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet. 2010;128:549-56 pubmed publisher
    ..was observed at SNPs in the CYP2R1 (cytochrome P450, family 2, subfamily R, polypeptide 1) and the GC (vitamin D binding protein) gene...
  34. Poynter J, Jacobs E, Figueiredo J, Lee W, Conti D, Campbell P, et al. Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev. 2010;19:525-36 pubmed publisher
    ..Overall, our results do not provide evidence for a role of common genetic variants in VDR or GC in susceptibility to CRC. ..
  35. Gozdzik A, Zhu J, Wong B, Fu L, Cole D, Parra E. Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry. J Steroid Biochem Mol Biol. 2011;127:405-12 pubmed publisher
    Variants of the vitamin D binding protein (VDBP) gene appear to be associated with levels of the main circulating vitamin D metabolite, 25-hydroxyvitamin D [(25(OH)D]...
  36. Yang M, Qin Z, Zhu Y, Li Y, Qin Y, Jing Y, et al. Vitamin D-binding protein in cerebrospinal fluid is associated with multiple sclerosis progression. Mol Neurobiol. 2013;47:946-56 pubmed publisher
    ..Vitamin D-binding protein (DBP), gelsolin, albumin, etc. showed more than a 1.5-fold difference between the two groups...
  37. Bosse Y, Lemire M, Poon A, Daley D, He J, Sandford A, et al. Asthma and genes encoding components of the vitamin D pathway. Respir Res. 2009;10:98 pubmed publisher
    ..Multilocus models testing genes in the same pathway are potentially more effective to evaluate the risk of asthma, but the effects are not uniform across populations. ..
  38. Weinstein S, Mondul A, Kopp W, Rager H, Virtamo J, Albanes D. Circulating 25-hydroxyvitamin D, vitamin D-binding protein and risk of prostate cancer. Int J Cancer. 2013;132:2940-7 pubmed publisher
    ..To further elucidate this association, we examined the influence of vitamin D-binding protein (DBP), the primary transporter of vitamin D compounds in the circulation...
  39. Yang F, Bergeron J, Linehan L, Lalley P, Sakaguchi A, Bowman B. Mapping and conservation of the group-specific component gene in mouse. Genomics. 1990;7:509-16 pubmed
    ..The mouse GC gene was mapped to chromosome 5, where the ALB and AFP genes are also located, demonstrating conservation of the three genes in vertebrate species. ..
  40. Braun A, Bichlmaier R, Cleve H. Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types. Hum Genet. 1992;89:401-6 pubmed
    ..chain reaction products, including the coding region for amino acids 416 and 420, of the vitamin-D-binding protein (DBP, group-specific component, GC) shows allele-specific differences...
  41. Bakke P, Zhu G, Gulsvik A, Kong X, Agusti A, Calverley P, et al. Candidate genes for COPD in two large data sets. Eur Respir J. 2011;37:255-63 pubmed publisher
    ..05). This study has replicated associations to COPD phenotypes in the STAT1, NFKBIB/SIRT2 and GC genes in two independent populations, the associations of the former two genes representing novel findings. ..
  42. Kasuga I, Pare P, Ruan J, Connett J, Anthonisen N, Sandford A. Lack of association of group specific component haplotypes with lung function in smokers. Thorax. 2003;58:790-3 pubmed
    ..The GC haplotype does not contribute to reduced lung function in this cohort of smokers. ..
  43. Cooke N, Willard H, David E, George D. Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism. Hum Genet. 1986;73:225-9 pubmed
    Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4...
  44. Kurylowicz A, Ramos Lopez E, Bednarczuk T, Badenhoop K. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes. 2006;114:329-35 pubmed
    Vitamin D-binding protein (DBP) genetic variants have an influence on vitamin D status and, therefore, they may contribute to the development of autoimmune diseases...
  45. Ishii T, Keicho N, Teramoto S, Azuma A, Kudoh S, Fukuchi Y, et al. Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis. Eur Respir J. 2001;18:753-7 pubmed
    ..However, no association between this polymorphism of Gc-globulin and susceptibility to diffuse panbronchiolitis was found. ..
  46. Rehder D, Nelson R, Borges C. Glycosylation status of vitamin D binding protein in cancer patients. Protein Sci. 2009;18:2036-42 pubmed publisher
    On the basis of the results of activity studies, previous reports have suggested that vitamin D binding protein (DBP) is significantly or even completely deglycosylated in cancer patients, eliminating the molecular precursor of the ..
  47. Ma T, Yin X, Han R, Ding J, Zhang H, Han X, et al. Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. Int J Environ Res Public Health. 2017;14: pubmed publisher
    Humans are inevitably exposed to ubiquitous phthalate esters (PAEs). In utero exposure to di-n-butyl phthalate (DBP) induces abnormal development of the testis and reproductive tract in male offspring, which correspond closely with the ..
  48. Nifant ev I, Shlyakhtin A, Bagrov V, Minyaev M, Churakov A, Karchevsky S, et al. Mono-BHT heteroleptic magnesium complexes: synthesis, molecular structure and catalytic behavior in the ring-opening polymerization of cyclic esters. Dalton Trans. 2017;46:12132-12146 pubmed publisher
    ..The free energies of model dimeric [(DBP)Mg(μ-OMe)(Sub)]2 and monomeric (DBP)Mg(OMe)(Sub)2 products on treatment of [(DBP)Mg(μ-..
  49. Pouwels S, Lascaris B, Nienhuijs S, Arthur Bouwman R, Buise M. Validation of the Nexfin® non-invasive continuous blood pressure monitoring validated against Riva-Rocci/Korotkoff in a bariatric patient population. J Clin Anesth. 2017;39:89-95 pubmed publisher
    ..Mean differences were 7.8±6.9mmHg for SBP and 8.0±7.2mmHg for DBP. Using the revised protocol, the Nexfin® device was not able to pass validation...
  50. Adir M, Salmon Divon M, Combelles C, Mansur A, Cohen Y, Machtinger R. In Vitro Exposure of Human Luteinized Mural Granulosa Cells to Dibutyl Phthalate Affects Global Gene Expression. Toxicol Sci. 2017;160:180-188 pubmed publisher
    Exposure to dibutyl phthalate (DBP) is ubiquitous among women of reproductive age. Previous studies in animal models and in human cells in vitro have shown that exposure to DBP disrupts ovarian function...
  51. Cakmak O, Cimen S, Tarhan H, Ekin R, Akarken I, Ulker V, et al. Listening to music during shock wave lithotripsy decreases anxiety, pain, and dissatisfaction : A randomized controlled study. Wien Klin Wochenschr. 2017;129:687-691 pubmed publisher
    ..Hemodynamic parameters including systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded before and after the session...
  52. Montoya Pachongo C, Douterelo I, Noakes C, Camargo Valero M, Sleigh A, Escobar Rivera J, et al. Field assessment of bacterial communities and total trihalomethanes: Implications for drinking water networks. Sci Total Environ. 2018;616-617:345-354 pubmed publisher are necessary to increase the awareness of O&M practices in DWDNs required to reduce biofilm formation and maintain appropriate microbiological and chemical water quality, in relation to biofilm detachment and DBP formation.
  53. Kunikullaya K, Goturu J, Muradi V, Hukkeri P, Kunnavil R, Doreswamy V, et al. Combination of music with lifestyle modification versus lifestyle modification alone on blood pressure reduction - A randomized controlled trial. Complement Ther Clin Pract. 2016;23:102-9 pubmed publisher
    ..Mean (SD) of diastolic BP (DBP) pre and post intervention were overall = 85.1(6.8) and 83(8.7){P = 0.004}, awake = 87.7(7...
  54. Qin Z, Qin Y, Liu S. Alteration of DBP levels in CSF of patients with MS by proteomics analysis. Cell Mol Neurobiol. 2009;29:203-10 pubmed publisher
    ..the identification made by MALDI-TOF/MS revealed that one of the most significant differential proteins was DBP (vitamin D-binding protein), which decreased in the experimental group...
  55. Yaseri M, Afarideh M, Hosseini M, Yousefifard M, Rafei A, Koohpayehzadeh J, et al. Zero and Five End-Digit Preference and Blood Pressure Quality of Care Revisited. Arch Iran Med. 2017;20:633-639 pubmed
    To determine the rate of zero and five end-digit preference (EDP) for systolic and diastolic blood pressures (SBP and DBP, respectively) and risk factors amongst a representative sample of Iranian adults in the year 2011.
  56. Poma G, Malysheva S, Goscinny S, Malarvannan G, Voorspoels S, Covaci A, et al. Occurrence of selected halogenated flame retardants in Belgian foodstuff. Chemosphere. 2018;194:256-265 pubmed publisher
    ..TBBPA, DPs, TBPH and γ-HBCD occurred with a frequency of less than 5%. TBBPS, 26-DBP, HBB, TBB and BTBPE were not detected in any of the analyzed food samples.
  57. Mehta A, Doshi R, Chaudhry Z, Jacobs D, Vakil R, Lee C, et al. Benefits of commercial weight-loss programs on blood pressure and lipids: a systematic review. Prev Med. 2016;90:86-99 pubmed publisher
    ..on study design, interventions, and mean change in systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglycerides, and ..
  58. Lu Y, Lin M, Aitken R. Exposure of spermatozoa to dibutyl phthalate induces abnormal embryonic development in a marine invertebrate Galeolaria caespitosa (Polychaeta: Serpulidae). Aquat Toxicol. 2017;191:189-200 pubmed publisher
    In this study, we have investigated the impact of dibutyl phthalate (DBP) on early embryogenesis in a sessile marine invertebrate, Galeolaria caespitosa...
  59. Esteban C, Geuskens M, Ena J, Mishal Z, Macho A, Torres J, et al. Receptor-mediated uptake and processing of vitamin D-binding protein in human B-lymphoid cells. J Biol Chem. 1992;267:10177-83 pubmed
    Vitamin D-binding protein (DBP), a member of a multigene family including alpha-fetoprotein (AFP) and albumin, is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells...
  60. Spitsyn V, Nafikova A, Spitsyna N, Afanas eva I. [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol]. Genetika. 2001;37:698-707 pubmed
    ..The concentrations of IgM and IgG depended on the HP, GC, and PI phenotypes. The total and direct reacting bilirubin concentrations depended on the erythrocytic-enzyme phenotypes (ACP1, PGM1, and GLO1) in both TC and control groups. ..