visfatin

Summary

Gene Symbol: visfatin
Description: nicotinamide phosphoribosyltransferase
Alias: 1110035O14Rik, PBEF, PBEF1, VISFATIN, nicotinamide phosphoribosyltransferase, NAmPRTase, pre-B cell-enhancing factor, pre-B-cell colony-enhancing factor 1
Species: human
Products:     visfatin

Top Publications

  1. Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol. 1994;14:1431-7 pubmed
    A novel gene coding for the pre-B-cell colony-enhancing factor (PBEF) has been isolated from a human peripheral blood lymphocyte cDNA library. The expression of this gene is induced by pokeweed mitogen and superinduced by cycloheximide...
  2. Curat C, Wegner V, Sengenes C, Miranville A, Tonus C, Busse R, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia. 2006;49:744-7 pubmed
    ..monocyte chemotactic protein 1, macrophage inflammatory protein 1alpha, IL-8) and the adipokines resistin and visfatin than did mature adipocytes, as assessed by real-time PCR analysis...
  3. Pagano C, Pilon C, Olivieri M, Mason P, Fabris R, Serra R, et al. Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans. J Clin Endocrinol Metab. 2006;91:3165-70 pubmed
    b>Visfatin was recently identified as a protein highly expressed and secreted in adipose tissue with insulin-mimetic effect and is a candidate hormone to help explain the association among adipose tissue expansion, insulin resistance, and ..
  4. Pilz S, Mangge H, Obermayer Pietsch B, Marz W. Visfatin/pre-B-cell colony-enhancing factor: a protein with various suggested functions. J Endocrinol Invest. 2007;30:138-44 pubmed
    ..colony-enhancing factor (PBEF) was recently found in high levels in visceral fat, and was therefore renamed visfatin. This new adipocytokine exerts insulin-mimetic effects in mice and in cultured cells by binding to and activating ..
  5. Adya R, Tan B, Chen J, Randeva H. Pre-B cell colony enhancing factor (PBEF)/visfatin induces secretion of MCP-1 in human endothelial cells: role in visfatin-induced angiogenesis. Atherosclerosis. 2009;205:113-9 pubmed publisher
    b>Visfatin and Monocyte-Chemoattractant-Protein-1 (MCP-1) are elevated in cardiovascular pathologies, insulin-resistant and diabetic states. Visfatin has been reported to exhibit pro-angiogenic actions in human endothelial cells...
  6. Ognjanovic S, Ku T, Bryant Greenwood G. Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium. Am J Obstet Gynecol. 2005;193:273-82 pubmed
    ..Although it had no chemotaxic effects, it was antiapoptotic for both amniotic epithelial cells and fibroblasts and may protect these cells against apoptosis that is induced by chronic distension, labor, or infection. ..
  7. Moschen A, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, et al. Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol. 2007;178:1748-58 pubmed
    ..Some adipocytokines such as adiponectin and leptin affect immune and inflammatory functions. Visfatin (pre-B cell colony-enhancing factor) has recently been identified as a new adipocytokine affecting insulin ..
  8. Araki S, Dobashi K, Kubo K, Kawagoe R, Yamamoto Y, Kawada Y, et al. Plasma visfatin concentration as a surrogate marker for visceral fat accumulation in obese children. Obesity (Silver Spring). 2008;16:384-8 pubmed publisher
    This study was designed to elucidate whether the plasma visfatin level reflects visceral or subcutaneous fat accumulation and metabolic derangement in obese children...
  9. Zhong M, Tan H, Gong H, Wang S, Zhang Y, Zhang W. Increased serum visfatin in patients with metabolic syndrome and carotid atherosclerosis. Clin Endocrinol (Oxf). 2008;69:878-84 pubmed publisher
    b>Visfatin is a newly identified adipocytokine and recent studies indicated that visfatin may have potential proinflammatory effect. However, its pathophysiological role in the metabolic syndrome (MetS) is not fully understood...

More Information

Publications102 found, 100 shown here

  1. Hammarstedt A, Pihlajamaki J, Rotter Sopasakis V, Gogg S, Jansson P, Laakso M, et al. Visfatin is an adipokine, but it is not regulated by thiazolidinediones. J Clin Endocrinol Metab. 2006;91:1181-4 pubmed
    b>Visfatin was recently reported to be expressed in human adipose tissue and to exert insulin-mimicking effects. The objective of this study was to examine whether visfatin is a true adipokine and is expressed in isolated fat cells...
  2. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez Reino J, et al. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65:1198-201 pubmed
    ..To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheumatoid arthritis and to compare them with levels in healthy controls...
  3. Tokunaga A, Miura A, Okauchi Y, Segawa K, Fukuhara A, Okita K, et al. The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects. Endocr J. 2008;55:205-12 pubmed
    b>Visfatin is a novel adipocytokine that is expressed by the visceral fat cells. We investigated the role of genetic variation in the visfatin gene in the pathophysiology of type 2 diabetes and clinical variables in Japanese subjects...
  4. Lopez Bermejo A, Chico Julià B, Fernández Balsells M, Recasens M, Esteve E, Casamitjana R, et al. Serum visfatin increases with progressive beta-cell deterioration. Diabetes. 2006;55:2871-5 pubmed
    b>Visfatin has shown to be increased in type 2 diabetes but to be unrelated to insulin sensitivity. We hypothesized that visfatin is associated with insulin secretion in humans...
  5. Haider D, Mittermayer F, Schaller G, Artwohl M, Baumgartner Parzer S, Prager G, et al. Free fatty acids normalize a rosiglitazone-induced visfatin release. Am J Physiol Endocrinol Metab. 2006;291:E885-90 pubmed
    ..whether this salutary action of TZD is associated with altered release of the insulin-mimetic adipocytokine visfatin. In this study, we investigated whether visfatin concentrations are altered by FFA and TZD treatment...
  6. Esteghamati A, Alamdari A, Zandieh A, Elahi S, Khalilzadeh O, Nakhjavani M, et al. Serum visfatin is associated with type 2 diabetes mellitus independent of insulin resistance and obesity. Diabetes Res Clin Pract. 2011;91:154-8 pubmed publisher
    The aim of this study was to evaluate the association of serum visfatin, adiponectin and leptin with 2 diabetes mellitus (T2DM) in the context of the role of obesity or insulin resistance, which is not well understood...
  7. Chen M, Chung F, Chang D, Tsai J, Huang H, Shin S, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2006;91:295-9 pubmed
    b>Visfatin (also known as pre-B cell colony-enhancing factor or PBEF) is a cytokine that is highly expressed in visceral fat and whose blood levels correlate with obesity...
  8. Shackelford R, Bui M, Coppola D, Hakam A. Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers. Int J Clin Exp Pathol. 2010;3:522-7 pubmed
    b>Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of nicotinamide adenine dinucleotide (NAD(+)) synthesis and is required for cell growth, survival, DNA replication and repair, and angiogenesis...
  9. van der Veer E, Nong Z, O Neil C, Urquhart B, Freeman D, Pickering J. Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. Circ Res. 2005;97:25-34 pubmed
    ..reports, PBEF did not have attributes of a cytokine but instead imparted the cell with increased nicotinamide phosphoribosyltransferase activity...
  10. Khan J, Tao X, Tong L. Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat Struct Mol Biol. 2006;13:582-8 pubmed
    b>Nicotinamide phosphoribosyltransferase (NMPRTase) has a crucial role in the salvage pathway of NAD+ biosynthesis, and a potent inhibitor of NMPRTase, FK866, can reduce cellular NAD+ levels and induce apoptosis in tumors...
  11. Sun G, Bishop J, Khalili S, Vasdev S, Gill V, Pace D, et al. Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men. Am J Clin Nutr. 2007;85:399-404 pubmed
    b>Visfatin is an insulin-mimicking adipokine. Visfatin is elevated in obesity and type 2 diabetes. However, its role in glucose and lipid metabolism in healthy humans is unclear...
  12. Luk T, Malam Z, Marshall J. Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity. J Leukoc Biol. 2008;83:804-16 pubmed publisher
    Pre-B cell colony-enhancing factor (PBEF), also known as visfatin, is a highly conserved, 52-kDa protein found in living species from bacteria to humans...
  13. Chan T, Chen Y, Chen H, Lee C, Jong S, Tsai E. Increased plasma visfatin concentrations in women with polycystic ovary syndrome. Fertil Steril. 2007;88:401-5 pubmed
    To test the hypothesis that plasma visfatin concentrations will be higher in women with polycystic ovary syndrome (PCOS) than in women without PCOS. Clinical study. University hospital. A total of 52 women were evaluated...
  14. Nowell M, Richards P, Fielding C, Ognjanovic S, Topley N, Williams A, et al. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2006;54:2084-95 pubmed
    ..whether interleukin-6 (IL-6) trans-signaling directs the expression of pre-B cell colony-enhancing factor (PBEF) in vitro and in vivo...
  15. Wang B, Hasan M, Alvarado E, Yuan H, Wu H, Chen W. NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene. 2011;30:907-21 pubmed publisher
    b>Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in regenerating nicotinamide adenine dinucleotide (NAD(+)) from nicotinamide in mammals...
  16. Friebe D, Neef M, Kratzsch J, Erbs S, Dittrich K, Garten A, et al. Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans. Diabetologia. 2011;54:1200-11 pubmed publisher
    b>Nicotinamide phosphoribosyltransferase (NAMPT) is a multifunctional protein potentially involved in obesity and glucose metabolism...
  17. Rongvaux A, Shea R, Mulks M, Gigot D, Urbain J, Leo O, et al. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol. 2002;32:3225-34 pubmed
    ..displaying significant homology with PBEF, has been identified as a nicotinamide phosphoribosyltranferase (NAmPRTase), an enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis...
  18. Bottcher Y, Teupser D, Enigk B, Berndt J, Kloting N, Schön M, et al. Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans. J Clin Endocrinol Metab. 2006;91:2725-31 pubmed
    b>Visfatin is a peptide suggested to play a role in glucose homeostasis. In the present study, we investigated the role of genetic variation in the visfatin gene in the pathophysiology of obesity/type 2 diabetes mellitus (T2DM)...
  19. Yan J, Tang N, Tang J, Jia E, Wang M, Wang Q, et al. Genetic variant in visfatin gene promoter is associated with decreased risk of coronary artery disease in a Chinese population. Clin Chim Acta. 2010;411:26-30 pubmed publisher
    b>Visfatin is a newly identified pro-inflammatory adipokine expressed predominantly in visceral fat. Previous studies have suggested a role for visfatin in low-grade inflammation and regulation of lipid metabolism...
  20. Garten A, Petzold S, Barnikol Oettler A, Korner A, Thasler W, Kratzsch J, et al. Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes. Biochem Biophys Res Commun. 2010;391:376-81 pubmed publisher
    Circulating NAMPT (PBEF/visfatin) has pleiotropic functions and is secreted from adipocytes...
  21. Pittelli M, Formentini L, Faraco G, Lapucci A, Rapizzi E, Cialdai F, et al. Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J Biol Chem. 2010;285:34106-14 pubmed publisher
    The NAD rescue pathway consists of two enzymatic steps operated by nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide mononucleotide adenylyltransferases...
  22. Fan Y, Meng S, Wang Y, Cao J, Wang C. Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-?B signaling pathway. Int J Mol Med. 2011;27:607-15 pubmed publisher
    ..Exogenous nicotinamide mononucleotide (NMN), the product of nicotinamide phosphoribosyltransferase (NAMPT) activity, mimicked the effects of visfatin on MAPK (p38, ERK1/2)-NF-?B activation and ..
  23. Krzyzanowska K, Krugluger W, Mittermayer F, Rahman R, Haider D, Shnawa N, et al. Increased visfatin concentrations in women with gestational diabetes mellitus. Clin Sci (Lond). 2006;110:605-9 pubmed
    The recently discovered adipocytokine visfatin has insulin-like properties. It lowers blood glucose and improves insulin sensitivity; however, clinical data on visfatin are limited...
  24. Jian W, Luo T, Gu Y, Zhang H, Zheng S, Dai M, et al. The visfatin gene is associated with glucose and lipid metabolism in a Chinese population. Diabet Med. 2006;23:967-73 pubmed
    b>Visfatin is a newly discovered adipokine found in abundance in visceral fat. It lowers plasma glucose in humans and mice...
  25. Kim J, Kim E, Jeong B, Min Y, Park J, Kim E, et al. Visfatin stimulates proliferation of MCF-7 human breast cancer cells. Mol Cells. 2010;30:341-5 pubmed publisher
    ..b>Visfatin has recently been established as a novel adipokine that is highly enriched in visceral fat...
  26. Kitani T, Okuno S, Fujisawa H. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. FEBS Lett. 2003;544:74-8 pubmed
    A cDNA encoding the homolog of the human pre-B-cell colony-enhancing factor (PBEF), a cytokine-like secreted protein, was isolated from a rat cDNA library...
  27. Berndt J, Kloting N, Kralisch S, Kovacs P, Fasshauer M, Schön M, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes. 2005;54:2911-6 pubmed
    ..Recently, visfatin was identified as an adipokine, which is predominantly secreted from visceral adipose tissue both in humans and ..
  28. Moschen A, Geiger S, Gerner R, Tilg H. Pre-B cell colony enhancing factor/NAMPT/visfatin and its role in inflammation-related bone disease. Mutat Res. 2010;690:95-101 pubmed publisher
    ..Pre-B cell colony enhancing factor (PBEF)/nicotinamide phosphoribosyl transferase (NAMPT)/visfatin is a pleiotropic mediator acting as growth factor, cytokine and enzyme involved in energy and nicotinamide ..
  29. Adeghate E. Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions. Curr Med Chem. 2008;15:1851-62 pubmed
    b>Visfatin is a newly discovered adipocyte hormone with a direct relationship between plasma visfatin level and type 2 diabetes mellitus...
  30. Aller R, de Luis D, Izaola O, Sagrado M, Conde R, Velasco M, et al. Influence of visfatin on histopathological changes of non-alcoholic fatty liver disease. Dig Dis Sci. 2009;54:1772-7 pubmed publisher
    ..The aim of the present study was to explore the relation of visfatin with underlying histopathological changes of NAFLD patients...
  31. Romacho T, Azcutia V, Vázquez Bella M, Matesanz N, Cercas E, Nevado J, et al. Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia. 2009;52:2455-2463 pubmed publisher
    Extracellular pre-B cell colony-enhancing factor/nicotinamide phosphoribosyltransferase/visfatin (ePBEF/NAMPT/visfatin) is an adipocytokine, whose circulating levels are enhanced in metabolic disorders, such as diabetes mellitus and ..
  32. Chang Y, Chang T, Lee W, Chuang L. The relationship of visfatin/pre-B-cell colony-enhancing factor/nicotinamide phosphoribosyltransferase in adipose tissue with inflammation, insulin resistance, and plasma lipids. Metabolism. 2010;59:93-9 pubmed publisher
    Visfatin/pre-B-cell colony-enhancing factor (PBEF)/nicotinamide phosphoribosyltransferase (Nampt) has been proposed as an insulin-mimicking adipocytokine predominantly secreted from visceral adipose tissue (VAT) and correlated with ..
  33. Kolsgaard M, Wangensteen T, Brunborg C, Joner G, Holven K, Halvorsen B, et al. Elevated visfatin levels in overweight and obese children and adolescents with metabolic syndrome. Scand J Clin Lab Invest. 2009;69:858-64 pubmed publisher
    ..We investigated the association between these conditions and serum levels of visfatin, adiponectin and leptin. 175 overweight and obese boys and girls aged 3-17 years...
  34. Filippatos T, Tsimihodimos V, Derdemezis C, Gazi I, Saougos V, Mikhailidis D, et al. Increased plasma visfatin concentration is a marker of an atherogenic metabolic profile. Nutr Metab Cardiovasc Dis. 2013;23:330-6 pubmed publisher
    b>Visfatin is associated with atherosclerosis-related diseases. We assessed in non-diabetic individuals the association of plasma visfatin levels with cardiovascular disease (CVD) risk and the atherosclerosis-related metabolic variables...
  35. Patel S, Mistry T, Brown J, Digby J, Adya R, Desai K, et al. A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis. Peptides. 2010;31:51-7 pubmed publisher
    ..mortality from prostate cancer within the obese population we looked to investigate the role of the adipokine visfatin in LNCaP and PC3 prostate cancer cell lines...
  36. Kukla M, Mazur W, Bułdak R, Zwirska Korczala K. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. Mol Med. 2011;17:1397-410 pubmed publisher
    ..b>Visfatin was described as an adipokine with immunomodulating and proinflammatory properties that promotes B-cell ..
  37. Kim S, Park H, Bae Y, Ahn S, Wee H, Yun I, et al. Curcumin down-regulates visfatin expression and inhibits breast cancer cell invasion. Endocrinology. 2012;153:554-63 pubmed publisher
    Obesity is frequently associated with breast cancer. Such associations are possibly mediated by adipokines. Visfatin, an adipokine, has recently been shown to be related to the development and progression of breast cancer...
  38. Jia S, Li Y, Parodo J, Kapus A, Fan L, Rotstein O, et al. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest. 2004;113:1318-27 pubmed
    Pre-B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally identified as a growth factor for early stage B cells...
  39. Akturk M, Altinova A, Mert I, Buyukkagnici U, Sargin A, Arslan M, et al. Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester. J Endocrinol Invest. 2008;31:610-3 pubmed
    Our aim is to investigate visfatin concentration and its relationship to glycated hemoglobin (HbA1c), insulin resistance, lipid parameters, and neonatal birth weight in women with gestational diabetes mellitus (GDM)...
  40. Bae Y, Bae M, Kim S, Lee J, Wee H, Bae S. Upregulation of fibroblast growth factor-2 by visfatin that promotes endothelial angiogenesis. Biochem Biophys Res Commun. 2009;379:206-11 pubmed publisher
    ..Recently, we have demonstrated that visfatin, a novel adipokine, has angiogenic activity...
  41. Blakemore A, Meyre D, Delplanque J, Vatin V, Lecoeur C, Marre M, et al. A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity. Obesity (Silver Spring). 2009;17:1549-53 pubmed publisher
    b>Visfatin was recently reported as a novel adipokine encoded by the NAMPT (PBEF1) gene...
  42. Toruner F, Altinova A, Bukan N, Arslan E, Akbay E, Ersoy R, et al. Plasma visfatin concentrations in subjects with type 1 diabetes mellitus. Horm Res. 2009;72:33-7 pubmed publisher
    b>Visfatin is a recently discovered adipokine, and its circulating concentrations have not been adequately studied in type 1 diabetes mellitus (DM)...
  43. Liu S, Qiao S, Yuan J, Liu D. Visfatin stimulates production of monocyte chemotactic protein-1 and interleukin-6 in human vein umbilical endothelial cells. Horm Metab Res. 2009;41:281-6 pubmed publisher
    ..b>Visfatin is a novel adipokine involved in regulation of inflammatory cytokines, however, associations of visfatin with ..
  44. Bae Y, Park H, Kim S, Kim J, Kang Y, Kim J, et al. Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis. Cardiovasc Res. 2011;89:436-45 pubmed publisher
    Our aims were to determine the role of Notch1 in mediating visfatin-induced angiogenesis and to explore potential target genes involved...
  45. Malam Z, Parodo J, Waheed F, Szaszi K, Kapus A, Marshall J. Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase. J Immunol. 2011;186:6474-84 pubmed publisher
    Pre-B cell colony-enhancing factor ([PBEF] also known as Nampt/visfatin) is a pleiotropic 52-kDa cytokine-like molecule whose activity has been implicated in multiple inflammatory disease states...
  46. Cerna D, Li H, Flaherty S, Takebe N, Coleman C, Yoo S. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012;287:22408-17 pubmed publisher
    ..GMX1778 is a specific inhibitor of nicotinamide phosphoribosyltransferase, a rate-limiting enzyme required for the regeneration of NAD(+) from nicotinamide...
  47. Bae S, Kim S, Kim J, Kim J, Koo T, Jang H, et al. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. FEBS Lett. 2006;580:4105-13 pubmed
    b>Visfatin has been originally identified as a growth factor for early stage B cells and recently known as an adipokine. Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells...
  48. Körner A, Bottcher Y, Enigk B, Kiess W, Stumvoll M, Kovacs P. Effects of genetic variation in the visfatin gene (PBEF1) on obesity, glucose metabolism, and blood pressure in children. Metabolism. 2007;56:772-7 pubmed
    b>Visfatin is a peptide predominantly expressed in visceral adipose tissue and was hypothesized to be related to obesity and insulin resistance...
  49. Filippatos T, Derdemezis C, Kiortsis D, Tselepis A, Elisaf M. Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome. J Endocrinol Invest. 2007;30:323-6 pubmed
    b>Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties...
  50. Burgos E, Schramm V. Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase. Biochemistry. 2008;47:11086-96 pubmed publisher
    Human nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2...
  51. Bo S, Ciccone G, Baldi I, Gambino R, Mandrile C, Durazzo M, et al. Plasma visfatin concentrations after a lifestyle intervention were directly associated with inflammatory markers. Nutr Metab Cardiovasc Dis. 2009;19:423-30 pubmed publisher
    The biological activity and regulation of the novel adipokine visfatin are still largely unknown. Our aim was to evaluate if visfatin plasma concentrations may be influenced by a lifestyle intervention...
  52. Kim J, Bae Y, Bae M, Kim S, Park H, Wee H, et al. Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis. Biochim Biophys Acta. 2009;1793:1759-67 pubmed publisher
    ..We have recently shown that a novel adipokine visfatin promotes endothelial angiogenesis...
  53. Tabassum R, Mahendran Y, Dwivedi O, Chauhan G, Ghosh S, Marwaha R, et al. Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children. Diabetes. 2012;61:626-31 pubmed publisher
    ..Variants of four genes (PBEF1 [rs3801266] [P = 4.5 × 10(-4)], IL6 [rs2069845] [P = 8.7 × 10(-4)], LEPR [rs1137100] [P = 1...
  54. Kendal C, Bryant Greenwood G. Pre-B-cell colony-enhancing factor (PBEF/Visfatin) gene expression is modulated by NF-kappaB and AP-1 in human amniotic epithelial cells. Placenta. 2007;28:305-14 pubmed
    ..Pre-B-cell colony-enhancing factor (PBEF) is expressed in the human fetal membranes and is up-regulated by labor, severe infection and inflammatory stimuli...
  55. Yilmaz M, Saglam M, Carrero J, Qureshi A, Caglar K, Eyileten T, et al. Serum visfatin concentration and endothelial dysfunction in chronic kidney disease. Nephrol Dial Transplant. 2008;23:959-65 pubmed
    ..Recently, visfatin, a protein with insulin-mimetic properties, was shown to be associated with sVCAM-1...
  56. Retnakaran R, Youn B, Liu Y, Hanley A, Lee N, Park J, et al. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Clin Endocrinol (Oxf). 2008;69:885-93 pubmed publisher
    Here we use a novel ELISA that is specific for full-length visfatin (PBEF/NAMPT), compare it with the existing C-terminal based assay and use it to investigate associations of visfatin with metabolic parameters...
  57. Zhu J, Schott M, Liu R, Shen B, Wang Q, Mao X, et al. Intensive glycemic control lowers plasma visfatin levels in patients with type 2 diabetes. Horm Metab Res. 2008;40:801-5 pubmed publisher
    b>Visfatin is an independent association factor for type 2 diabetes mellitus (T2DM)...
  58. Liu P, Li H, Cepeda J, Zhang L, Cui X, Garcia J, et al. Critical role of PBEF expression in pulmonary cell inflammation and permeability. Cell Biol Int. 2009;33:19-30 pubmed publisher
    Previous studies in our lab have identified pre-B-cell colony enhancing factor (PBEF) as a novel biomarker in acute lung injury...
  59. El Mesallamy H, Kassem D, El Demerdash E, Amin A. Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus. Metabolism. 2011;60:63-70 pubmed publisher
    Recently, vaspin and visfatin/Nampt have been identified as interesting novel adipokines having insulin-sensitizing and insulin-mimetic effects, respectively...
  60. Machura E, Ziora K, Ziora D, Świtęochowska E, Halkiewicz F, Oswiecimska J, et al. Serum visfatin levels are decreased in schoolchildren with atopic asthma. Neuro Endocrinol Lett. 2012;33:559-64 pubmed
    ..Studies about the potential role of novel proinflammatory adiopcytokine - visfatin are lacking...
  61. Haider D, Schindler K, Schaller G, Prager G, Wolzt M, Ludvik B. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. J Clin Endocrinol Metab. 2006;91:1578-81 pubmed
    The insulin-mimetic adipocytokine visfatin has been linked to obesity. The influence of weight loss on plasma visfatin concentrations in obese subjects is unknown yet...
  62. Haider D, Schaller G, Kapiotis S, Maier C, Luger A, Wolzt M. The release of the adipocytokine visfatin is regulated by glucose and insulin. Diabetologia. 2006;49:1909-14 pubmed
    The novel insulin-mimetic adipocytokine visfatin has been linked to the metabolic syndrome, but its regulation has not been characterised to date...
  63. Chan T, Chen Y, Lee C, Chou F, Wu L, Jong S, et al. Decreased plasma visfatin concentrations in women with gestational diabetes mellitus. J Soc Gynecol Investig. 2006;13:364-7 pubmed
    To test the hypothesis that plasma visfatin concentrations will be lower in women with gestational diabetes mellitus, we evaluated women with gestational diabetes mellitus and healthy pregnant women, and then correlated their plasma ..
  64. Fernandez Real J, Moreno J, Chico B, Lopez Bermejo A, Ricart W. Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance. Diabetes Care. 2007;30:616-21 pubmed
    b>Visfatin is a novel adipokine that is predominantly secreted by visceral adipose tissue. Accumulation of visceral adipose tissue is also associated with iron metabolism...
  65. Reddy P, Umesh S, Thota B, Tandon A, Pandey P, Hegde A, et al. PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value. Cancer Biol Ther. 2008;7:663-8 pubmed
    ..Pre-B-cell colony enhancing factor 1 gene (PBEF1) encodes Nicotinamide phosphoribosyltransferase (NAmPRTase), which catalyses the rate limiting step in the salvage pathway of NAD metabolism in ..
  66. Chen W, Bao J, Feng J, Hu P, Shi Z, Wu L. Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis. Clin Chem Lab Med. 2010;48:1141-5 pubmed publisher
    The goal of this study was to investigate the distribution of visfatin in paired serum and synovial fluid (SF) samples from patients with osteoarthritis (OA), and in serum from healthy controls...
  67. Lu L, Wang C, Yu T, Hung W, Chiu C, Chung F, et al. Interpretation of elevated plasma visfatin concentrations in patients with ST-elevation myocardial infarction. Cytokine. 2012;57:74-80 pubmed publisher
    b>Visfatin is a cytokine that is expressed in many tissues, including the heart, and has been proposed to play a role in plaque destabilization leading to acute myocardial injury...
  68. Cea M, Cagnetta A, Fulciniti M, Tai Y, Hideshima T, Chauhan D, et al. Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood. 2012;120:3519-29 pubmed publisher
    ..Our data therefore define a key role of Nampt in MM biology, providing the basis for a novel targeted therapeutic approach. ..
  69. Fazeli M, Dashti H, Akbarzadeh S, Assadi M, Aminian A, Keramati M, et al. Circulating levels of novel adipocytokines in patients with colorectal cancer. Cytokine. 2013;62:81-5 pubmed publisher
    ..The aim of this matched case-control study was to explore circulating novel adipocytokines, such as serum visfatin, omentin-1 and vaspin levels in patients with CRC...
  70. Liu P, Li H, Cepeda J, Xia Y, Kempf J, Ye H, et al. Regulation of inflammatory cytokine expression in pulmonary epithelial cells by pre-B-cell colony-enhancing factor via a nonenzymatic and AP-1-dependent mechanism. J Biol Chem. 2009;284:27344-51 pubmed publisher
    ..Growing evidence indicates that PBEF is a nicotinamide phosphoribosyltransferase involved in the mammalian salvage pathway of NAD synthesis...
  71. Gonzalez Gay M, Vazquez Rodriguez T, Garcia Unzueta M, Berja A, Miranda Filloy J, De Matias J, et al. Visfatin is not associated with inflammation or metabolic syndrome in patients with severe rheumatoid arthritis undergoing anti-TNF-alpha therapy. Clin Exp Rheumatol. 2010;28:56-62 pubmed
    b>Visfatin is an insulin-mimetic adipokine. In non-rheumatoid arthritis (RA) patients circulating levels of visfatin are correlated with the amount of visceral fat. Recent studies have disclosed an implication of visfatin in inflammation...
  72. Wanecq E, Prevot D, Carpene C. Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes. J Physiol Biochem. 2009;65:351-9 pubmed publisher
    ..It is also an enzyme displaying nicotinamide phosphoribosyltransferase activity (Nampt)...
  73. Mayi T, Duhem C, Copin C, Bouhlel M, Rigamonti E, Pattou F, et al. Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages. FEBS J. 2010;277:3308-20 pubmed publisher
    ..Within the adipose tissue, adipose tissue macrophages are the major source of visfatin/pre-B-cell colony-enhancing factor/nicotinamide phosphoribosyl transferase...
  74. Gao W, Mao Q, Feng A, Sun H, Sun W, Lu X, et al. Inhibition of pre-B cell colony-enhancing factor attenuates inflammation and apoptosis induced by pandemic H1N1 2009 in lung endothelium. Respir Physiol Neurobiol. 2011;178:235-41 pubmed publisher
    ..In this report, we observed the effect of pre-B cell colony-enhancing factor (PBEF) on the inflammation and apoptosis in H1N1-infected human pulmonary microvascular endothelial cells (HPMECs)...
  75. Taşkesen D, Kirel B, Us T. Serum visfatin levels, adiposity and glucose metabolism in obese adolescents. J Clin Res Pediatr Endocrinol. 2012;4:76-81 pubmed publisher
    b>Visfatin, an adipokine, has insulin-mimetic effects. The main determinants of both the production and the physiologic role of visfatin are still unclear...
  76. Stephens J, Vidal Puig A. An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity. Curr Opin Lipidol. 2006;17:128-31 pubmed
    The aim of this article is to summarize all of the recent studies on pre-B cell colony-enhancing factor visfatin, a ubiquitously expressed secreted protein that has been implicated in obesity and insulin resistance...
  77. Revollo J, Körner A, Mills K, Satoh A, Wang T, Garten A, et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6:363-75 pubmed
    Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the NAD biosynthetic pathway...
  78. Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, et al. Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PLoS ONE. 2009;4:e7897 pubmed publisher
    b>Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of different forms of cancer...
  79. Senolt L, Krystůfková O, Hulejová H, Kuklová M, Filková M, Cerezo L, et al. The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy. Cytokine. 2011;55:116-21 pubmed publisher
    b>Visfatin, also known as pre-B cell colony-enhancing factor, was recently characterized as a potent pro-inflammatory mediator in rheumatoid arthritis (RA)...
  80. Presumey J, Courties G, Louis Plence P, Escriou V, Scherman D, Pers Y, et al. Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis. Ann Rheum Dis. 2013;72:1717-24 pubmed publisher
    b>Nicotinamide phosphoribosyltransferase (NAMPT)/pre-B-cell colony-enhancing factor/visfatin exerts multiple functions and has been implicated in the pathogenesis of rheumatoid arthritis...
  81. Cagnetta A, Cea M, Calimeri T, Acharya C, Fulciniti M, Tai Y, et al. Intracellular NAD? depletion enhances bortezomib-induced anti-myeloma activity. Blood. 2013;122:1243-55 pubmed publisher
    We recently demonstrated that Nicotinamide phosphoribosyltransferase (Nampt) inhibition depletes intracellular NAD? content leading, to autophagic multiple myeloma (MM) cell death...
  82. Ognjanovic S, Bao S, Yamamoto S, Garibay Tupas J, Samal B, Bryant Greenwood G. Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes. J Mol Endocrinol. 2001;26:107-17 pubmed
    Pre-B-cell colony enhancing factor (PBEF) was first isolated from an activated peripheral blood lymphocyte cDNA library and was found to be involved in the maturation of B-cell precursors...
  83. Dogru T, Sonmez A, Tasci I, Bozoglu E, Yilmaz M, Genc H, et al. Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance. Diabetes Res Clin Pract. 2007;76:24-9 pubmed
    b>Visfatin, a new adipokine, facilitates adipogenesis and has insulin-mimetic properties...
  84. Jin H, Jiang B, Tang J, Lu W, Wang W, Zhou L, et al. Serum visfatin concentrations in obese adolescents and its correlation with age and high-density lipoprotein cholesterol. Diabetes Res Clin Pract. 2008;79:412-8 pubmed publisher
    b>Visfatin was recently identified as an adipocytokine and has insulin mimetic properties, but its role in adolescents remains largely unknown...
  85. Johansson L, Johansson L, Ridderstrale M. The visfatin (PBEF1) G-948T gene polymorphism is associated with increased high-density lipoprotein cholesterol in obese subjects. Metabolism. 2008;57:1558-62 pubmed publisher
    The newly discovered adipokine visfatin has been hypothesized to be related to obesity and insulin resistance...
  86. Bełtowski J. Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?. Med Sci Monit. 2006;12:RA112-9 pubmed
    ..Apelin and visfatin are two recently described adipokines, although they are also synthesized outside adipose tissue...
  87. Kim S, Bae S, Choi K, Park S, Jun H, Lee J, et al. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem Biophys Res Commun. 2007;357:150-6 pubmed
    Adipose tissue is highly vascularized and requires the angiogenic properties for its mass growth. Visfatin has been recently characterized as a novel adipokine, which is preferentially produced by adipose tissue...
  88. Kadoglou N, Sailer N, Moumtzouoglou A, Kapelouzou A, Tsanikidis H, Vitta I, et al. Visfatin (nampt) and ghrelin as novel markers of carotid atherosclerosis in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2010;118:75-80 pubmed publisher
    b>Visfatin (nampt) and ghrelin are the most recently identified adipocytokines, but their role in atherosclerosis is poorly clarified...
  89. Varma V, Yao Borengasser A, Rasouli N, Bodles A, Phanavanh B, Lee M, et al. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. J Clin Endocrinol Metab. 2007;92:666-72 pubmed
    b>Visfatin (VF) is a recently described adipokine preferentially secreted by visceral adipose tissue (VAT) with insulin mimetic properties...
  90. van der Veer E, Ho C, O Neil C, Barbosa N, Scott R, Cregan S, et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem. 2007;282:10841-5 pubmed
    ..We identified a relationship between aging of human vascular smooth muscle cells (SMCs) and nicotinamide phosphoribosyltransferase (Nampt/PBEF/Visfatin), the rate-limiting enzyme for NAD+ salvage from nicotinamide...
  91. Yang H, Yang T, Baur J, Perez E, Matsui T, Carmona J, et al. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007;130:1095-107 pubmed
    ..We discuss the relevance of these findings to understanding how nutrition modulates physiology and to the evolution of apoptosis. ..
  92. Xie H, Tang S, Luo X, Huang J, Cui R, Yuan L, et al. Insulin-like effects of visfatin on human osteoblasts. Calcif Tissue Int. 2007;80:201-10 pubmed
    b>Visfatin (also known as pre-B cell colony-enhancing factor or PBEF) is a novel adipocytokine that is highly expressed in visceral fat and upregulated in obesity and type 2 diabetes mellitus...