viperin

Summary

Gene Symbol: viperin
Description: radical S-adenosyl methionine domain containing 2
Alias: 2510004L01Rik, cig33, cig5, vig1, radical S-adenosyl methionine domain-containing protein 2, cytomegalovirus-induced gene 5 protein, viperin, virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Species: human
Products:     viperin

Top Publications

  1. Jiang D, Guo H, Xu C, Chang J, Gu B, Wang L, et al. Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol. 2008;82:1665-78 pubmed
    ..ISGs that are induced in Huh7 cells by IFN-alpha and/or up-regulated in HCV-infected livers, we discovered that viperin, ISG20, and double-stranded RNA-dependent protein kinase (PKR) noncytolytically inhibited the replication of HCV ..
  2. Hinson E, Cresswell P. The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. Proc Natl Acad Sci U S A. 2009;106:20452-7 pubmed publisher
    ..Here we show that the IFN-induced antiviral protein viperin, which localizes to the cytosolic face of the ER and inhibits HCV, localizes to lipid droplets...
  3. Duschene K, Broderick J. The antiviral protein viperin is a radical SAM enzyme. FEBS Lett. 2010;584:1263-7 pubmed publisher
    b>Viperin, an interferon-inducible antiviral protein, is shown to bind an iron-sulfur cluster, based on iron analysis as well as UV-Vis and electron paramagnetic resonance spectroscopic data...
  4. Rivieccio M, Suh H, Zhao Y, Zhao M, Chin K, Lee S, et al. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J Immunol. 2006;177:4735-41 pubmed
    ..One of the most highly up-regulated genes on microarray was the protein viperin/cig5...
  5. Seo J, Yaneva R, Hinson E, Cresswell P. Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science. 2011;332:1093-7 pubmed publisher
    b>Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown...
  6. Chan Y, Chang T, Liao C, Lin Y. The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. J Virol. 2008;82:10455-64 pubmed publisher
    b>Viperin is identified as an antiviral protein induced by interferon (IFN), viral infections, and pathogen-associated molecules...
  7. Shaveta G, Shi J, Chow V, Song J. Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme. Biochem Biophys Res Commun. 2010;391:1390-5 pubmed publisher
    b>Viperin is an interferon-inducible protein inhibiting many DNA and RNA viruses...
  8. Helbig K, Eyre N, Yip E, Narayana S, Li K, Fiches G, et al. The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A. Hepatology. 2011;54:1506-17 pubmed publisher
    The interferon-stimulated gene, viperin, has been shown to have antiviral activity against hepatitis C virus (HCV) in the context of the HCV replicon, although the molecular mechanisms responsible are not well understood...
  9. Nasr N, Maddocks S, Turville S, Harman A, Woolger N, Helbig K, et al. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood. 2012;120:778-88 pubmed publisher
    ..In MDMs, viperin was the most up-regulated interferon-stimulated genes, and it significantly inhibited HIV-1 production...

More Information

Publications105 found, 100 shown here

  1. Jiang D, Weidner J, Qing M, Pan X, Guo H, Xu C, et al. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. J Virol. 2010;84:8332-41 pubmed publisher
    ..In contrast, three IFN-induced cellular enzymes, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in viral proteins and/or RNA ..
  2. Wang S, Wu X, Pan T, Song W, Wang Y, Zhang F, et al. Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33. J Gen Virol. 2012;93:83-92 pubmed publisher
    b>Viperin is a type-I and -II interferon-inducible intracytoplasmic protein that mediates antiviral activity against several viruses. A previous study has reported that viperin could limit hepatitis C virus (HCV) replication in vitro...
  3. Carlton Smith C, Elliott R. Viperin, MTAP44, and protein kinase R contribute to the interferon-induced inhibition of Bunyamwera Orthobunyavirus replication. J Virol. 2012;86:11548-57 pubmed publisher
    ..overexpressed individual IFN-stimulated genes, we found that protein kinase R (PKR), MTAP44, and particularly viperin appreciably restricted BUNV replication...
  4. Helbig K, Lau D, Semendric L, Harley H, Beard M. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology. 2005;42:702-10 pubmed
    ..One ISG significantly elevated in all patients was viperin, an evolutionary conserved ISG that has antiviral activity against human cytomegalovirus...
  5. Tan K, Olfat F, Phoon M, Hsu J, Howe J, Seet J, et al. In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection. J Gen Virol. 2012;93:1269-77 pubmed publisher
    Influenza A virus has caused a number of pandemics in past decades, including the recent H1N1-2009 pandemic. Viperin is an interferon (IFN)-inducible protein of innate immunity, and acts as a broad-spectrum antiviral protein...
  6. Teng T, Foo S, Simamarta D, Lum F, Teo T, Lulla A, et al. Viperin restricts chikungunya virus replication and pathology. J Clin Invest. 2012;122:4447-60 pubmed publisher
    ..a cohort of CHIKV-infected patients revealed that type I IFNs controlled CHIKV infection via RSAD2 (which encodes viperin), an enigmatic multifunctional IFN-stimulated gene (ISG)...
  7. Wang X, Hinson E, Cresswell P. The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe. 2007;2:96-105 pubmed
    ..Here we show that the interferon-induced protein viperin inhibits influenza A virus release from the plasma membrane of infected cells...
  8. Hinson E, Cresswell P. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J Biol Chem. 2009;284:4705-12 pubmed publisher
    b>Viperin is an evolutionarily conserved interferon-inducible protein that localizes to the endoplasmic reticulum (ER) and inhibits a number of DNA and RNA viruses...
  9. Mattijssen S, Pruijn G. Viperin, a key player in the antiviral response. Microbes Infect. 2012;14:419-26 pubmed publisher
    b>Viperin is an antiviral protein that is induced by different viruses, type I interferon, poly(I:C) and lipopolysaccharide, which is localized to the endoplasmic reticulum and lipid droplets...
  10. Chin K, Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc Natl Acad Sci U S A. 2001;98:15125-30 pubmed
    ..We have named the protein viperin (for virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)...
  11. Skovbjerg S, Nordén R, Martner A, Samuelsson E, Hynsjö L, Wold A. Intact Pneumococci Trigger Transcription of Interferon-Related Genes in Human Monocytes, while Fragmented, Autolyzed Bacteria Subvert This Response. Infect Immun. 2017;85: pubmed publisher
    ..We suggest that interferon-related pathways are important for elimination of pneumococci and that autolysis contributes to virulence by extinguishing these pathways. ..
  12. Oguejiofor C, Cheng Z, Abudureyimu A, Anstaett O, Brownlie J, Fouladi Nashta A, et al. Global transcriptomic profiling of bovine endometrial immune response in vitro. II. Effect of bovine viral diarrhea virus on the endometrial response to lipopolysaccharide. Biol Reprod. 2015;93:101 pubmed publisher
    ..Infection with ncpBVDV can thus compromise immune function and pregnancy recognition, thereby potentially predisposing infected cows to postpartum bacterial endometritis and reduced fertility. ..
  13. Mao F, Li J, Zhang Y, Xiang Z, Zhang Y, Yu Z. Molecular cloning and functional analysis of tumor necrosis factor receptor-associated factor 6 (TRAF6) in Crossastrea gigas. Fish Shellfish Immunol. 2017;68:37-45 pubmed publisher
    ..of CgTRAF6 resulted in the down-regulation of several putative anti-viral signaling (IRF) and effector (PKR & Viperin) molecules coding genes, 7 days post-injection...
  14. Zhang J, Fu X, Zhang Y, Zhu W, Zhou Y, Yuan G, et al. Chitosan and anisodamine improve the immune efficacy of inactivated infectious spleen and kidney necrosis virus vaccine in Siniperca chuatsi. Fish Shellfish Immunol. 2019;89:52-60 pubmed publisher
    ..mRNA expressions showed these adjuvants induced the cytokines of early immune responses (TNF-α, Viperin) in both spleen and mesonephron by real time quantitative RT-PCR assays...
  15. Liu X, Chen N, Gao X, Zhang Y, Li X, Zhang Y, et al. The infection of red seabream iridovirus in mandarin fish (Siniperca chuatsi) and the host immune related gene expression profiles. Fish Shellfish Immunol. 2018;74:474-484 pubmed publisher
    ..The expression level of ten genes including interferon-related factors (IRFs) IRF1 and IRF7, Mx, Viperin, JAK1, STAT1, TCR?, TNF?, IL-1? and IL-8 during experimental infection were monitored at different point of time ..
  16. Fu X, Li N, Lin Q, Guo H, Liu L, Huang Z, et al. Early protein ORF086 is an effective vaccine candidate for infectious spleen and kidney necrosis virus in mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2015;46:200-5 pubmed publisher
    ..of non-specific and specific immune related genes revealed that the expression levels of IRF-7, IRAK1, Mx, Viperin, and IgM were strongly up-regulated in the vaccinated groups post-immunization...
  17. Green T, Rolland J, Vergnes A, Raftos D, Montagnani C. OsHV-1 countermeasures to the Pacific oyster's anti-viral response. Fish Shellfish Immunol. 2015;47:435-43 pubmed publisher
    ..gigas gill cells occurred after the up-regulation of interferon-stimulated genes (viperin, PKR, ADAR). In a second objective, we manipulated the host's anti-viral response by injecting C...
  18. Ramos P, Zimmerman K, Haddad S, Langefeld C, Medsger T, Feghali Bostwick C. Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets. Clin Epigenetics. 2019;11:58 pubmed publisher
    ..These data implicate epigenetic changes in the pathogenesis of SSc and suggest functional mechanisms in SSc etiology. ..
  19. Sarkar S, Balasuriya U, Horohov D, Chambers T. Equine herpesvirus-1 suppresses type-I interferon induction in equine endothelial cells. Vet Immunol Immunopathol. 2015;167:122-9 pubmed publisher
    ..Expression of the IFN response factor viperin, a marker of host cell type-I IFN responses, was also suppressed by T953 virus infection...
  20. Jounai K, Sugimura T, Morita Y, Ohshio K, Fujiwara D. Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice. Int Immunopharmacol. 2018;56:205-211 pubmed publisher
    ..The expression levels of anti-viral factors induced by IFNs, such as Isg15, Mx1, Oasl2 and Viperin, and an anti-bacterial factor Reg3?, were up-regulated in the small intestinal epithelial cells (IECs) of LC-..
  21. Lynch J, Werder R, Simpson J, Loh Z, Zhang V, Haque A, et al. Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity. J Allergy Clin Immunol. 2016;138:1326-1337 pubmed publisher
    ..Mechanistically, IL-33 downregulated viperin and interferon regulatory factor 7 gene expression and rapidly degraded IL-1 receptor-associated kinase 1 ..
  22. Ru J, Sun H, Fan H, Wang C, Li Y, Liu M, et al. MiR-23a facilitates the replication of HSV-1 through the suppression of interferon regulatory factor 1. PLoS ONE. 2014;9:e114021 pubmed publisher
    ..MiR-23a thus contributes to HSV-1 replication through the regulation of the IRF1-mediated antiviral signal pathway, which suggests that miR-23a may represent a promising target for antiviral treatments. ..
  23. Cheng Z, Chauhan L, Barry A, Abudureyimu A, Oguejiofor C, Chen X, et al. Acute bovine viral diarrhea virus infection inhibits expression of interferon tau-stimulated genes in bovine endometrium. Biol Reprod. 2017;96:1142-1153 pubmed publisher
    ..This in turn could reduce fertility and predispose cows to uterine disease, while evasion of the normal uterine immune response by ncpBVDV may contribute to maintenance and spreading of this economically important disease. ..
  24. Li W, Gorantla S, Gendelman H, Poluektova L. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Dis Model Mech. 2017;10:1489-1502 pubmed publisher
    ..In this manner, this new mouse model of neuroAIDS can facilitate diagnostic, therapeutic and viral eradication strategies for an infected nervous system. ..
  25. Arslan M, Yang X, Santhakumar D, Liu X, Hu X, Munir M, et al. Dynamic Expression of Interferon Lambda Regulated Genes in Primary Fibroblasts and Immune Organs of the Chicken. Genes (Basel). 2019;10: pubmed publisher
    ..KEGGs analysis) of the bursa of Fabricious and the thymus demonstrated an upregulation of crucial immune genes (viperin, IKKB, CCL5, IL1β, and AP1) as well as the antiviral signaling pathways...
  26. Poynter S, Leis E, Dewitte Orr S. In vitro transcribed dsRNA limits viral hemorrhagic septicemia virus (VHSV)-IVb infection in a novel fathead minnow (Pimephales promelas) skin cell line. Fish Shellfish Immunol. 2019;86:403-409 pubmed publisher
    ..dsRNA for 48 h and respond to dsRNA treatment by expressing high levels of three innate immune genes, viperin, ISG15, and Mx1...
  27. Mahony R, Gargan S, Roberts K, Bourke N, Keating S, Bowie A, et al. A novel anti-viral role for STAT3 in IFN-? signalling responses. Cell Mol Life Sci. 2017;74:1755-1764 pubmed publisher
    ..ISGs: PKR, OAS2, MxB and ISG15; while STAT3 expression had no effect upon induction of a separate ISG group: Viperin, IFI27, CXCL10 and CCL5...
  28. Hu X, Chen S, Jia C, Xue S, Dou C, Dai Z, et al. Gene expression profile and long non-coding RNA analysis, using RNA-Seq, in chicken embryonic fibroblast cells infected by avian leukosis virus J. Arch Virol. 2018;163:639-647 pubmed publisher
    ..These findings identify the expression profile of lncRNAs in chicken CEF cells infected by ALVJ virus and provide new insights into the molecular mechanisms of ALVJ infection. ..
  29. Tian J, Zhang X, Wu H, Liu C, Li Z, Hu X, et al. Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes. Front Microbiol. 2015;6:886 pubmed publisher
    ..Overexpression of ISG15 and Viperin inhibited virus replication, and knockdown of either enhanced virus replication...
  30. Joseph S, George N, Green Knox B, Treadwell E, Word B, Yim S, et al. Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI. J Autoimmun. 2019;96:147-157 pubmed publisher
    ..Thus, the results indicate epigenetics susceptibility in lupus, which may be associated with SLEDAI score and ethnicity. In addition, our findings support the importance of the Type 1 interferon pathway in lupus pathogenesis. ..
  31. Chemudupati M, Kenney A, Bonifati S, Zani A, McMichael T, Wu L, et al. From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections. Biochim Biophys Acta Mol Cell Res. 2019;1866:382-394 pubmed publisher
    ..to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to ..
  32. Fermin L, Pain S, Morel P, Gedye K, Kenyon P, Blair H. Effect of exogenous progesterone on embryo size and ewe uterine gene expression in an ovine 'dam size' model of maternal constraint. Reprod Fertil Dev. 2017;: pubmed publisher
    ..However, further research is required to investigate the timing of P4 administration and its impact on conception rates...
  33. Xu P, Cui L, Huang T, Zhang Z, Yang B, Chen C, et al. Genome-wide identification of quantitative trait transcripts for blood traits in the liver samples of a White Duroc × Erhualian F2 pig resource population. Physiol Genomics. 2016;48:573-9 pubmed publisher
    ..The findings improve our understanding of intrinsic relationships between the liver and blood cells and provide novel insights into the potential therapeutic targets of hematologic diseases. ..
  34. Zhang X, Wu H, Liu C, Sun X, Zu S, Tian J, et al. The function of feline stimulator of interferon gene (STING) is evolutionarily conserved. Vet Immunol Immunopathol. 2016;169:54-62 pubmed publisher
    ..Finally, STING activated the ISRE promoter and increased the expression of ISG15 and viperin. Collectively, our findings indicate that STING is involved in the regulation of the IFN-β pathway in felines. ..
  35. Zhang Y, Zhu M, Li G, Liu J, Zhai X, Wang R, et al. Identification and function analysis of canine stimulator of interferon gene (STING). Microb Pathog. 2017;113:202-208 pubmed publisher
    ..induced the IFN response via the IRF3 and NF-?B pathways and up-regulated the expression of ISG15 and viperin. However, knockdown of STING did not inhibit the IFN-? response triggered by poly(dA:dT), poly(I:C), or SeV...
  36. Sarkar S, Balasuriya U, Horohov D, Chambers T. The neuropathogenic T953 strain of equine herpesvirus-1 inhibits type-I IFN mediated antiviral activity in equine endothelial cells. Vet Microbiol. 2016;183:110-8 pubmed publisher
    ..EHV-1 infection inhibited expression of cellular antiviral proteins including IFN-stimulated gene 56 (ISG56) and viperin. Taken together these findings suggest that the neuropathogenic T953 strain of EHV-1 evades the host innate ..
  37. Biolatti M, Gugliesi F, Dell Oste V, Landolfo S. Modulation of the innate immune response by human cytomegalovirus. Infect Genet Evol. 2018;64:105-114 pubmed publisher
    ..g. IFI16, ND10 complex, viperin and APOBEC3) and review our current understanding of the mechanisms that HCMV has evolved to counteract both IFN ..
  38. Landgraf B, McCarthy E, Booker S. Radical S-Adenosylmethionine Enzymes in Human Health and Disease. Annu Rev Biochem. 2016;85:485-514 pubmed publisher
    ..biosynthesis; TYW1, wybutosine biosynthesis; ELP3, 5-methoxycarbonylmethyl uridine; and RSAD1 and viperin, both of unknown function. Aberrations in the genes encoding these proteins result in a variety of diseases...
  39. Nie L, Zhang Y, Dong W, Xiang L, Shao J. Involvement of zebrafish RIG-I in NF-κB and IFN signaling pathways: insights into functional conservation of RIG-I in antiviral innate immunity. Dev Comp Immunol. 2015;48:95-101 pubmed publisher
    ..the NF-κB and IFN signaling pathways, leading to the expression of TNF-α, IL-8 and IFN-induced Mx, ISG15, and viperin. However, knockdown of TRIM25 (a pivotal activator for RIG-I receptors) significantly suppressed the induced ..
  40. Zeng M, Chen S, Wang M, Chen A. [Advances in Avian Antiviral Innate Immune Effectors]. Bing Du Xue Bao. 2016;32:627-33 pubmed
    ..immune factors Mx and IFITM are both key antiviral effectors against influenza, while the antiviral mechanism of viperin remains to be completely elucidated...
  41. Liu P, Wang L, Kwang J, Yue G, Wong S. Transcriptome analysis of genes responding to NNV infection in Asian seabass epithelial cells. Fish Shellfish Immunol. 2016;54:342-52 pubmed publisher
    ..homolog 1-like (ASTE1), receptor-transporting protein 3 (RTP3), heat shock proteins 30 (HSP30) and 70 (HSP70), Viperin, interferon regulatory factor 3 (IRF3) and other genes related to innate immunity...
  42. Silva Vignato B, Coutinho L, Cesar A, Poleti M, Regitano L, Balieiro J. Comparative muscle transcriptome associated with carcass traits of Nellore cattle. BMC Genomics. 2017;18:506 pubmed publisher
    ..These results enlighten some of the molecular processes involved in muscle and fat deposition, which are economically important carcass traits for beef production. ..
  43. Barjesteh N, Shojadoost B, Brisbin J, Emam M, Hodgins D, Nagy Ã, et al. Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens. Vaccine. 2015;33:4843-9 pubmed publisher
    ..Moreover, the expression of several candidate genes, such as type I interferons, PKR, OAS, viperin and IFITM3 was quantified at 3, 8 and 18h post-treatment with TLR ligands...
  44. Oguejiofor C, Cheng Z, Abudureyimu A, Fouladi Nashta A, Wathes D. Global transcriptomic profiling of bovine endometrial immune response in vitro. I. Effect of lipopolysaccharide on innate immunity. Biol Reprod. 2015;93:100 pubmed publisher
  45. Martire S, Navone N, Montarolo F, Perga S, Bertolotto A. A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients. J Neuroimmunol. 2016;292:34-9 pubmed publisher
    ..However, we cannot confirm the predictive value of these candidate biomarkers. ..
  46. Wei X, Li X, Zheng X, Jia P, Wang J, Yang X, et al. Toll-like receptors and interferon associated immune factors responses to spring viraemia of carp virus infection in common carp (Cyprinus carpio). Fish Shellfish Immunol. 2016;55:568-76 pubmed publisher
    ..in all three fish and all three fish showed a relative fold increase of TLR2, TLR3 and TLR7, IFNa1, ISG15 and Vig1. Viral copies rapidly increased at 12 hpi then remained high until 5 dpi...
  47. Giugliano S, Kriss M, Golden Mason L, Dobrinskikh E, Stone A, Soto Gutierrez A, et al. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015;148:392-402.e13 pubmed publisher
    ..Recombinant type I and type III IFNs strongly up-regulated HLSEC transcription of IFN λ3 (IFNL3) and viperin (RSAD2), which inhibit replication of HCV...
  48. Clarke J, Davies L, Calvert J, Gliddon B, Al Shujari W, Aloia A, et al. Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses. J Gen Virol. 2016;97:95-109 pubmed publisher
    ..a low-level induction of IFN-β and poor induction of mRNA for the interferon-stimulated genes (ISGs) viperin, IFIT1 and CXCL10 in DENV-infected SK1⁻/⁻  compared with WT iMEFs...
  49. Gupta S, Termini J, Issac B, Guirado E, Stone G. Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. PLoS ONE. 2016;11:e0148929 pubmed publisher
    ..CD4+ T cells showed significant upregulation of ISG, including previously characterized HIV restriction factors Viperin, Tetherin, MxB, and ISG56. Interferon blockade studies implicated interferon-beta in this response...
  50. Zhong Z, Ji Y, Fu Y, Liu B, Zhu Q. Molecular characterization and expression analysis of the duck viperin gene. Gene. 2015;570:100-7 pubmed publisher
    b>Viperin is well known as one of the interferon-stimulated genes involved in innate immunity. Recent studies showed that this gene is mainly responsible for antiviral response to a large variety of viral infections...
  51. Van der Hoek K, Eyre N, Shue B, Khantisitthiporn O, Glab Ampi K, Carr J, et al. Viperin is an important host restriction factor in control of Zika virus infection. Sci Rep. 2017;7:4475 pubmed publisher
    ..One such ISG is viperin that has well documented antiviral activity against a wide range of viruses...
  52. Hilzendeger C, da Silva J, Henket M, Schleich F, Corhay J, Kebadze T, et al. Reduced sputum expression of interferon-stimulated genes in severe COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:1485-94 pubmed publisher
    ..Expression of interferons beta (IFN-?) and lambda1 (IL-29), IFN-stimulated genes (ISGs) MxA, OAS, and viperin were measured in total sputum cells by reverse transcription quantitative polymerase chain reaction (RT-qPCR)...
  53. Lesage Padilla A, Forde N, Poirée M, Healey G, Giraud Delville C, Reinaud P, et al. Maternal metabolism affects endometrial expression of oxidative stress and FOXL2 genes in cattle. PLoS ONE. 2017;12:e0189942 pubmed publisher
    ..Collectively, our findings prompt the need to fully understand the extent to which modifications in endometrial physiology drive the trajectory of conceptus development from implantation onwards when maternal metabolism is altered. ..
  54. Hauger H, Ritz C, Mortensen C, Mølgaard C, Metzdorff S, Frøkiær H, et al. Winter cholecalciferol supplementation at 55°N has little effect on markers of innate immune defense in healthy children aged 4-8 years: a secondary analysis from a randomized controlled trial. Eur J Nutr. 2018;: pubmed publisher
    ..gene expression of calprotectin (S100A9), lipocalin-2 (LCN2), beta-defensin-4 (DEFB4), interleukin-8 (IL-8), viperin (RSAD2), and the cathelicidin-antimicrobial-peptide (CAMP); ex vivo whole-blood lipopolysaccharide (LPS)-induced ..
  55. Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. J Neuroinflammation. 2016;13:136 pubmed publisher
    ..These findings put forward mechanism by which CBD exerts its anti-inflammatory effects as well as explain the beneficial role of CBD in pathological memory T cells and in autoimmune diseases. ..
  56. Porter J, Watson J, Roberts L, Gill S, Groves H, Dhariwal J, et al. Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium. J Antimicrob Chemother. 2016;71:2767-81 pubmed publisher
    ..M) of rhinovirus-induced type I IFN?, type III IFN?1 and type III IFN?2/3 mRNA and the IFN-stimulated genes viperin and MxA, yet had no effect on IL-6 and IL-8 mRNA...
  57. Khan K, Dô F, Marineau A, Doyon P, Clément J, Woodgett J, et al. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed publisher
    ..selected sets of IRF3-regulated IFN-stimulated genes (ISGs) such as those for ISG54 (Ifit2), ISG56 (Ifit1), and viperin (Rsad2)...
  58. Boruszewska D, Kowalczyk Zieba I, Sinderewicz E, Grycmacher K, Staszkiewicz J, Woclawek Potocka I. The effect of lysophosphatidic acid together with interferon tau on the global transcriptomic profile in bovine endometrial cells. Theriogenology. 2017;92:111-120 pubmed publisher
  59. Safi N, Haghani A, Ng S, Selvarajah G, Mustaffa Kamal F, Omar A. Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats. BMC Vet Res. 2017;13:92 pubmed publisher
    ..showed an increase in the expression of interferon-related genes and pro-inflammatory cytokines such as MX1, viperin, CXCL10, CCL8, RANTES, KC, MCP1, and IL8...
  60. Helbig K, Carr J, Calvert J, Wati S, Clarke J, Eyre N, et al. Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. PLoS Negl Trop Dis. 2013;7:e2178 pubmed publisher
    The host protein viperin is an interferon stimulated gene (ISG) that is up-regulated during a number of viral infections...
  61. Seo J, Cresswell P. Viperin regulates cellular lipid metabolism during human cytomegalovirus infection. PLoS Pathog. 2013;9:e1003497 pubmed publisher
    ..We show here that this increase is a consequence of the virus-induced redistribution of the host protein viperin to mitochondria and its capacity to interact with and block the function of the mitochondrial trifunctional ..
  62. Nelp M, Young A, Stepanski B, Bandarian V. Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role. Biochemistry. 2017;56:3874-3876 pubmed publisher
    b>Viperin (virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is a widely distributed protein that is expressed in response to infection and causes antiviral effects against a broad spectrum of viruses...
  63. Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, et al. Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles. J Virol. 2018;92: pubmed publisher
    ..This mechanism is controlled by the activity of the interferon-induced protein viperin, a broad-spectrum antiviral interferon-stimulated gene...
  64. Panayiotou C, Lindqvist R, Kurhade C, Vonderstein K, Pasto J, Edlund K, et al. Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation. J Virol. 2018;92: pubmed publisher
    ..to viral infection and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus-inhibitory protein, endoplasmic reticulum associated, IFN inducible), which shows antiviral activity ..
  65. Mattijssen S, Hinson E, Onnekink C, Hermanns P, Zabel B, Cresswell P, et al. Viperin mRNA is a novel target for the human RNase MRP/RNase P endoribonuclease. Cell Mol Life Sci. 2011;68:2469-80 pubmed publisher
    ..We confirmed the upregulation of the interferon-inducible viperin mRNA by RNAi experiments and this appeared to be independent of the interferon response...
  66. Jumat M, Huong T, Ravi L, Stanford R, Tan B, Sugrue R. Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis. Antiviral Res. 2015;114:11-20 pubmed publisher
    We examined the effect of respiratory syncytial virus (RSV) infection on viperin protein expression in the permissive HEp2 and non-permissive RAW 264.7 macrophage cell lines...
  67. Torres Odio S, Key J, Hoepken H, Canet Pons J, Valek L, Roller B, et al. Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. J Neuroinflammation. 2017;14:154 pubmed publisher
    ..Hence, our results identify PINK1 deficiency as an early modulator of innate immunity in neurons, which precedes late stages of neuroinflammation during alpha-synuclein spreading. ..
  68. Ohnishi J, Ayuzawa S, Nakamura S, Sakamoto S, Hori M, Sasaoka T, et al. Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study. Hum Genomics. 2017;11:21 pubmed publisher
    ..The up-regulation of the anti-viral type I IFN responsive genes and distinct metabolites in the plasma may represent systemic biological adaptations with a unique signature underlying spiritual/religious practices for Buddhists. ..
  69. Ai K, Luo K, Xia L, Gao W, Hu W, Qi Z, et al. Functional characterization of interferon regulatory factor 5 and its role in the innate antiviral immune response. Fish Shellfish Immunol. 2018;72:31-36 pubmed publisher
    ..Moreover, the expression profiles of Mx, IFN, Viperin, and IRF7, but not IRF3, were upregulated by overexpression of IRF5 in Epithelioma papulosum cyprinid cells (EPCs)..
  70. Doehle B, Chang K, Fleming L, McNevin J, Hladik F, McElrath M, et al. Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells. J Virol. 2012;86:8499-506 pubmed publisher
    ..These observations show that HIV-1 can indeed be recognized as a pathogen in infected cells and provide a novel and effective platform for defining the native innate immune programs of target cells of HIV-1 infection. ..
  71. Alfaiate D, Lucifora J, Abeywickrama Samarakoon N, Michelet M, Testoni B, Cortay J, et al. HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes. Antiviral Res. 2016;136:19-31 pubmed publisher
    ..on HBV replication, a strong type-I IFN response was observed, with interferon stimulated genes, RSAD2 (Viperin) and IFI78 (MxA) being highly induced...
  72. Zhu H, Cong J, Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci U S A. 1997;94:13985-90 pubmed
    ..These RNAs accumulate after infection with virus that has been inactivated by treatment with UV light, indicating that the inducer is present in virions. We conclude that human cytomegalovirus induces interferon-responsive mRNAs. ..
  73. Olofsson P, Jatta K, Wågsäter D, Gredmark S, Hedin U, Paulsson Berne G, et al. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Arterioscler Thromb Vasc Biol. 2005;25:e113-6 pubmed
    ..Gene arrays identified the cytomegalovirus-inducible gene 5 (cig5)/viperin among the genes most potently induced by LPS in human vascular biopsies...
  74. Severa M, Coccia E, Fitzgerald K. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J Biol Chem. 2006;281:26188-95 pubmed
    Here we identify Viperin as a highly inducible gene in response to lipopolysaccharide (LPS), double-stranded RNA (poly(I-C)) or Sendai virus (SV)...
  75. Lim E, Wu L, Malik H, Emerman M. The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses. Retrovirology. 2012;9:55 pubmed publisher
    b>Viperin, also known as RSAD2, is an interferon-inducible protein that potently restricts a broad range of different viruses such as influenza, hepatitis C virus, human cytomegalovirus and West Nile virus...
  76. Zahoor M, Xue G, Sato H, Murakami T, Takeshima S, Aida Y. HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. PLoS ONE. 2014;9:e106418 pubmed publisher
    ..MX1, MX2, ISG15, ISG20, IFIT1, IFIT2, IFIT3, IFI27, IFI44L, APOBEC3A, DDX58 (RIG-I), TNFSF10 (TRAIL), and RSAD2 (viperin) were confirmed by real-time quantitative PCR and were consistent with the microarray data...
  77. Mikulecký P, Andreeva E, Amara P, Weissenhorn W, Nicolet Y, Macheboeuf P. Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis. FEBS Lett. 2018;592:199-208 pubmed publisher
    b>Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses...
  78. McGillivary G, Jordan Z, Peeples M, Bakaletz L. Replication of respiratory syncytial virus is inhibited by the host defense molecule viperin. J Innate Immun. 2013;5:60-71 pubmed publisher
    ..We have used a microarray approach and showed that expression of the gene that encodes the antiviral protein viperin was significantly upregulated in the chinchilla nasopharynx up to 1 week after RSV challenge...
  79. Wang B, Fang Y, Wu Y, Koga K, Osuga Y, Lv S, et al. Viperin is induced following toll-like receptor 3 (TLR3) ligation and has a virus-responsive function in human trophoblast cells. Placenta. 2015;36:667-73 pubmed publisher
    b>Viperin, a virus-inducible antiviral protein, has been reported to inhibit the replication of a variety of viruses. However, its expression and function in trophoblast cells remains unclear...
  80. Moore L, Jarungsriapisit J, Nilsen T, Stefansson S, Taranger G, Secombes C, et al. Immune gene profiles in Atlantic salmon (salmo salar L.) post-smolts infected with SAV3 by bath-challenge show a delayed response and lower levels of gene transcription compared to injected fish. Fish Shellfish Immunol. 2017;62:320-331 pubmed publisher
    ..Despite this, high levels of the IFN-stimulated genes (ISGs) such as Mx and viperin were observed. The immune response in the i.m...
  81. Zhang J, Liu C, Zhao S, Guo S, Shen B. Molecular characterization and expression analyses of the Viperin gene in Larimichthys crocea (Family: Sciaenidae). Dev Comp Immunol. 2018;79:59-66 pubmed publisher
    In this study, we sequenced and characterized an interferon-stimulated gene Viperin homologue, LcViperin, from large yellow croaker (Larimichthys crocea)...
  82. Suh H, Zhao M, Rivieccio M, Choi S, Connolly E, Zhao Y, et al. Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. J Virol. 2007;81:9838-50 pubmed
    ..PIC also upregulated TLR3, thereby augmenting the primary (IFN-beta) and secondary (IDO and viperin) response genes upon subsequent stimulation with PIC...
  83. Greliche N, Germain M, Lambert J, Cohen W, Bertrand M, Dupuis A, et al. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. BMC Med Genet. 2013;14:36 pubmed publisher
    ..This study, the first genome-wide SNP interaction analysis conducted so far on VT risk, suggests that common SNPs are unlikely exerting strong interactive effects on the risk of disease. ..
  84. Upadhyay A, Vonderstein K, Pichlmair A, Stehling O, Bennett K, Dobler G, et al. Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. Cell Microbiol. 2014;16:834-48 pubmed publisher
    b>Viperin is an interferon-induced protein with a broad antiviral activity. This evolutionary conserved protein contains a radical S-adenosyl-l-methionine (SAM) domain which has been shown in vitro to hold a [4Fe-4S] cluster...
  85. Bai X, Yang H, Wan L, Wang P, Wang H, Yang X, et al. Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus. APMIS. 2017;125:170-175 pubmed publisher
    The aim of this study was to explore the role of viperin in the prevention of intrauterine infection of hepatitis B virus (HBV)...
  86. Clancy R, Markham A, Jackson T, Rasmussen S, Blumenberg M, Buyon J. Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block. Am J Physiol Heart Circ Physiol. 2017;313:H631-H640 pubmed publisher
    ..This study provides in vivo and in vitro transcriptome-support that injury may be mediated by an effect of Type I Interferon on fetal fibroblasts. ..
  87. Haldar S, Paul S, Joshi N, Dasgupta A, Chattopadhyay K. The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin. PLoS ONE. 2012;7:e31797 pubmed publisher
    b>Viperin, an antiviral protein, has been shown to contain a CX(3)CX(2)C motif, which is conserved in the radical S-adenosyl-methionine (SAM) enzyme family...
  88. Zhu C, Tang Y, Xu F, Zhou J. [Progress in studies of viperin, an important cellular antiviral factor]. Bing Du Xue Bao. 2015;31:91-6 pubmed
    b>Viperin is an endoplasmic reticulum (ER)-associated protein that has been identified as an innate antiviral protein...
  89. Fan H, Zhao G, Ren D, Liu F, Dong G, Hou Y. Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus. Immunol Lett. 2017;181:71-78 pubmed publisher
    ..Therefore, we conclude that the diagnosis and treatment of these immune-related diseases should consider the baseline gender-related differences. ..
  90. Upadhyay A, Stehling O, Panayiotou C, Rösser R, Lill R, Overby A. Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. J Biol Chem. 2017;292:13879-13889 pubmed publisher
    b>Viperin (RSAD2) is an interferon-stimulated antiviral protein that belongs to the radical S-adenosylmethionine (SAM) enzyme family...
  91. Yahya M, Rulli M, Toivonen L, Waris M, Peltola V. Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs. J Infect Dis. 2017;216:1099-1103 pubmed publisher
    ..We investigated myxovirus resistance protein A (MxA), viperin, and tripartite-motif 21 (TRIM21) messenger RNA indexes in nasal swabs as potential biomarkers of viral ..
  92. Li W, Mao L, Cao Y, Zhou B, Yang L, Han L, et al. Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. Virol J. 2017;14:202 pubmed publisher
    ..b>Viperin is one of the hundreds of interferon-stimulated genes (ISGs), and possesses a wide range of antiviral activities...