vif

Summary

Gene Symbol: vif
Description: p23
Alias: Vif
Species: Human immunodeficiency virus 1

Top Publications

  1. pmc Production of infectious virus and degradation of APOBEC3G are separable functional properties of human immunodeficiency virus type 1 Vif
    Sandra Kao
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bldg 4, Room 310, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460, USA
    Virology 369:329-39. 2007
  2. ncbi RNA and DNA binding properties of HIV-1 Vif protein: a fluorescence study
    Serena Bernacchi
    Architecture et Reactivite de l ARN, Universite Louis Pasteur de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg, France
    J Biol Chem 282:26361-8. 2007
  3. pmc Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidation
    Hendrik Huthoff
    Department of Infectious Diseases, King s College London School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital, London Bridge, London SE1 9RT, United Kingdom
    J Virol 81:3807-15. 2007
  4. ncbi Multifaceted antiviral actions of APOBEC3 cytidine deaminases
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, USA
    Trends Immunol 27:291-7. 2006
  5. pmc Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells
    Sandra Kao
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    Retrovirology 1:27. 2004
  6. pmc Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1
    Judd F Hultquist
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Virol 85:11220-34. 2011
  7. pmc Analysis of human APOBEC3H haplotypes and anti-human immunodeficiency virus type 1 activity
    Xiaojun Wang
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824 4320, USA
    J Virol 85:3142-52. 2011
  8. pmc APOBEC3G inhibits elongation of HIV-1 reverse transcripts
    Kate N Bishop
    Department of Infectious Diseases, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    PLoS Pathog 4:e1000231. 2008
  9. pmc Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation
    Craig Pace
    Centre for Clinical Immunology and Biomedical Statistics, 2nd Floor, North Block, Royal Perth Hospital, Wellington Street, Perth 6000, Western Australia
    J Virol 80:9259-69. 2006
  10. pmc Cytidine deamination induced HIV-1 drug resistance
    Lubbertus C F Mulder
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1090, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:5501-6. 2008

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Detail Information

Publications133 found, 100 shown here

  1. pmc Production of infectious virus and degradation of APOBEC3G are separable functional properties of human immunodeficiency virus type 1 Vif
    Sandra Kao
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bldg 4, Room 310, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460, USA
    Virology 369:329-39. 2007
    HIV-1 Vif regulates viral infectivity by inhibiting the encapsidation of APOBEC3G (APO3G) through proteasomal degradation of the protein...
  2. ncbi RNA and DNA binding properties of HIV-1 Vif protein: a fluorescence study
    Serena Bernacchi
    Architecture et Reactivite de l ARN, Universite Louis Pasteur de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg, France
    J Biol Chem 282:26361-8. 2007
    The HIV-1 viral infectivity factor (Vif) is a small basic protein essential for viral fitness and pathogenicity. Some "non-permissive" cell lines cannot sustain replication of Vif(-) HIV-1 virions...
  3. pmc Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidation
    Hendrik Huthoff
    Department of Infectious Diseases, King s College London School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital, London Bridge, London SE1 9RT, United Kingdom
    J Virol 81:3807-15. 2007
    The human immunodeficiency virus type-1 (HIV-1) accessory protein Vif serves to neutralize the human antiviral proteins apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G [A3G]) and A3F...
  4. ncbi Multifaceted antiviral actions of APOBEC3 cytidine deaminases
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, USA
    Trends Immunol 27:291-7. 2006
    ..Insights into how the action of A3G is circumvented by HIV-1 through the action of its Vif protein, and the surprising mechanisms by which A3G is regulated within the cell, offer exciting new opportunities ..
  5. pmc Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells
    Sandra Kao
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    Retrovirology 1:27. 2004
    The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions...
  6. pmc Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1
    Judd F Hultquist
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Virol 85:11220-34. 2011
    ..T lymphocytes, human immunodeficiency virus type 1 (HIV-1) encodes a protein called viral infectivity factor (Vif) that promotes pathogenesis by triggering the degradation of the retrovirus restriction factor APOBEC3G...
  7. pmc Analysis of human APOBEC3H haplotypes and anti-human immunodeficiency virus type 1 activity
    Xiaojun Wang
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824 4320, USA
    J Virol 85:3142-52. 2011
    ..domain (CDD) and inhibits the replication of retrotransposons and human immunodeficiency virus type 1 (HIV-1) in a Vif-resistant manner...
  8. pmc APOBEC3G inhibits elongation of HIV-1 reverse transcripts
    Kate N Bishop
    Department of Infectious Diseases, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    PLoS Pathog 4:e1000231. 2008
    APOBEC3G (A3G) is a host cytidine deaminase that, in the absence of Vif, restricts HIV-1 replication and reduces the amount of viral DNA that accumulates in cells...
  9. pmc Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation
    Craig Pace
    Centre for Clinical Immunology and Biomedical Statistics, 2nd Floor, North Block, Royal Perth Hospital, Wellington Street, Perth 6000, Western Australia
    J Virol 80:9259-69. 2006
    ..7 log(10) copies/ml; P = 0.001). Defective vif was strongly associated with HIV-1 hypermutation, with additional evidence for a contribution of vif amino acid ..
  10. pmc Cytidine deamination induced HIV-1 drug resistance
    Lubbertus C F Mulder
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1090, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:5501-6. 2008
    The HIV-1 Vif protein is essential for overcoming the antiviral activity of DNA-editing apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) cytidine deaminases...
  11. doi HIV-1 accessory proteins--ensuring viral survival in a hostile environment
    Michael H Malim
    Department of Infectious Diseases, King s College London School of Medicine, 2nd Floor, Borough Wing, Guy s Hospital, London Bridge, London, SE1 9RT, UK
    Cell Host Microbe 3:388-98. 2008
    ..Here, we discuss recent advances in understanding the interactions of the HIV-1 Nef, Vif, Vpu, and Vpr proteins with factors and pathways expressed in cells of the immune system...
  12. pmc Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity
    Rebecca S LaRue
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, and Comparative and Molecular Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Virol 84:8193-201. 2010
    All lentiviruses except equine infectious anemia virus (EIAV) use the small accessory protein Vif to counteract the restriction activity of the relevant APOBEC3 (A3) proteins of their host species...
  13. doi The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements
    Ya Lin Chiu
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Annu Rev Immunol 26:317-53. 2008
    ..of APOBEC3G and related cytidine deaminases as one class of host restriction factors and of the action of HIV-1 Vif as a specific APOBEC3G antagonist have stimulated intense scientific interest...
  14. pmc Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent
    Edward P Browne
    Department of Microbiology, New York University School of Medicine, New York, 10016, USA
    Virology 387:313-21. 2009
    ..We conclude that cytidine deamination is the mechanism by which APOBEC3G restricts HIV-1...
  15. pmc Polymorphisms and splice variants influence the antiretroviral activity of human APOBEC3H
    Ariana Harari
    Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1090, New York City, NY 10029, USA
    J Virol 83:295-303. 2009
    ..All APOBEC3H variants tested were resistant to HIV-1 Vif, the viral protein that efficiently counteracts APOBEC3G/3F activity...
  16. pmc APOBEC3H haplotypes and HIV-1 pro-viral vif DNA sequence diversity in early untreated human immunodeficiency virus-1 infection
    P A Gourraud
    Department of Neurology, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA
    Hum Immunol 72:207-12. 2011
    ..locus on chromosome 22, paired with population sequences of pro-viral human immunodeficiency virus-1 (HIV-1) vif from peripheral blood mononuclear cells, from 96 recently HIV-1-infected treatment-naive adults...
  17. pmc Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition
    Yannick Bulliard
    School of Life Sciences and Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    J Virol 83:12611-21. 2009
    ..a large-scale mutagenesis-based analysis of the APOBEC3G N terminus, testing mutants for (i) inhibition of vif-defective HIV-1 infection and Alu retrotransposition, (ii) RNA binding, and (iii) oligomerization...
  18. pmc A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR
    Tao Zhou
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 4320, USA
    Retrovirology 6:31. 2009
    ..NKR that potently restricted wild-type HIV-1 replication. Interestingly, this restriction resembled the APOBEC3G/APOBEC3F pattern in that viral replication was inhibited from the second round of replication cycle at a post-entry step...
  19. pmc The localization of APOBEC3H variants in HIV-1 virions determines their antiviral activity
    Marcel Ooms
    Division of Infectious Diseases, Department of Medicine, and Department of Microbiology, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Virol 84:7961-9. 2010
    ..Thus, the antiviral activity of A3H haplotypes is determined by its incorporation into the viral core, in proximity to the reverse transcription complex...
  20. pmc Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1
    Lindi Tan
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    FASEB J 23:279-87. 2009
    ..Variants of A3H have divergent antiviral activities against HIV-1-Vif-deficient viruses...
  21. ncbi Identification of a host protein essential for assembly of immature HIV-1 capsids
    Concepcion Zimmerman
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Nature 415:88-92. 2002
    ..Furthermore, in cells the HP68-Gag complex is associated with HIV-1 Vif, which is involved in virion morphogenesis and infectivity...
  22. pmc Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins
    Wenyan Zhang
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    PLoS ONE 3:e3963. 2008
    ..Formation of infectious HIV-1 requires the suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through the common mechanism of recruiting the Cullin5-ElonginB-..
  23. pmc A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity
    Anjie Zhen
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 84:1902-11. 2010
    ..However, it is not clear whether HIV-1 Vif can recognize and suppress the antiviral activity of A3H variants, as it does with other APOBEC3 proteins...
  24. pmc HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation
    Gaëlle Mercenne
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084, Strasbourg Cedex, France
    Nucleic Acids Res 38:633-46. 2010
    The HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells (including most natural HIV-1 targets) by counteracting the cellular cytosine deaminases APOBEC-3G (hA3G) and hA3F...
  25. pmc Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization
    Ying Dang
    Department of Microbiology, Michigan State University, East Lansing, Michigan 48824 4320, USA
    J Virol 83:8544-52. 2009
    The function of lentiviral Vif proteins is to neutralize the host antiviral cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F)...
  26. doi Novel targets for HIV therapy
    Warner C Greene
    Gladstone Institute of Virology and Immunology, San Francisco, CA, USA
    Antiviral Res 80:251-65. 2008
    ..This review contains concise summaries of discussed topics that included Vif-APOBEC3G, LEDGF/p75, TRIM 5alpha, virus assembly and maturation, and Vpu...
  27. ncbi Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway
    Andrew Mehle
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 279:7792-8. 2004
    Viruses must overcome diverse intracellular defense mechanisms to establish infection. The Vif (virion infectivity factor) protein of human immunodeficiency virus 1 (HIV-1) acts by overcoming the antiviral activity of APOBEC3G (CEM15), a ..
  28. pmc The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex
    Julien R C Bergeron
    Department of Infectious Diseases, King s College London School of Medicine, London, United Kingdom
    PLoS Pathog 6:e1000925. 2010
    The HIV-1 viral infectivity factor (Vif) protein recruits an E3 ubiquitin ligase complex, comprising the cellular proteins elongin B and C (EloBC), cullin 5 (Cul5) and RING-box 2 (Rbx2), to the anti-viral proteins APOBEC3G (A3G) and ..
  29. ncbi Cytidine deamination of retroviral DNA by diverse APOBEC proteins
    Kate N Bishop
    Department of Infectious Diseases, Guy s, King s and St Thomas School of Medicine, King s College London, London, SE1 9RT, United Kingdom
    Curr Biol 14:1392-6. 2004
    ..The HIV Vif protein is able to protect both viruses from this innate restriction to infection...
  30. pmc Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis
    Delphine Lavens
    Department of Medical Protein Research, VIB, Department of Biochemistry, Ghent University, A Baertsoenkaai 3, 9000 Ghent
    Nucleic Acids Res 38:1902-12. 2010
    ..The HIV-1 accessory protein Vif subverts Apobec3G by targeting it for proteasomal degradation...
  31. pmc Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics
    John S Albin
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Expert Rev Mol Med 12:e4. 2010
    ..HIV-1 thwarts this restriction activity through its accessory protein virion infectivity factor (Vif), which uses multiple mechanisms to prevent APOBEC3 proteins such as APOBEC3G and APOBEC3F from entering viral ..
  32. ncbi HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation
    Mariana Santa-Marta
    Unidade de Retrovirus e Infecçôes Associadas, Centro de Patogenese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Av das Forcas Armadas, 1649 019 Lisboa, Portugal
    J Biol Chem 280:8765-75. 2005
    ..HIV-1 viral infectivity factor (Vif) protein was shown to protect the virus from APOBEC3G-mediated viral cDNA hypermutation...
  33. pmc Regulation of APOBEC3 proteins by a novel YXXL motif in human immunodeficiency virus type 1 Vif and simian immunodeficiency virus SIVagm Vif
    Erez Pery
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 83:2374-81. 2009
    ..In HIV-1-infected CD4+ T cells, the viral accessory protein Vif binds to APOBEC3G (A3G), APOBEC3F (A3F), and APOBEC3C (A3C) and targets these proteins for polyubiquitination by ..
  34. pmc A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G
    Gongying Chen
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 83:8674-82. 2009
    The amino-terminal region of the Vif molecule in human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV) contains a conserved SLV/Ix4Yx9Y motif that was first described in 1992, but the importance of ..
  35. pmc HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain
    Yasumasa Iwatani
    Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi 460 0001, Japan
    Proc Natl Acad Sci U S A 106:19539-44. 2009
    ..Abrogation of A3G function involves the HIV-1 Vif protein, which binds A3G and serves as an adapter molecule to recruit A3G to a Cullin5-based E3 ubiquitin ligase ..
  36. doi A positively selected APOBEC3H haplotype is associated with natural resistance to HIV-1 infection
    Rachele Cagliani
    Scientific Institute IRCCS E Medea, via Don L Monza 20, Bosisio Parini LC, Italy
    Evolution 65:3311-22. 2011
    ..Hap I carries a protein-destabilizing variant and a residue conferring resistance to Vif-mediated degradation...
  37. doi The APOBEC3C crystal structure and the interface for HIV-1 Vif binding
    Shingo Kitamura
    Clinical Research Center, Department of Infectious Diseases and Immunology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Nat Struct Mol Biol 19:1005-10. 2012
    ..However, HIV-1 viral infectivity factor (Vif) counteracts the antiviral activity of most A3 proteins by targeting them for proteasomal degradation...
  38. pmc Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities
    Shingo Kitamura
    Laboratory of Infectious Diseases, Department of Infectious Diseases and Immunology, Clinical Research Center, National Hospital Organization Nagoya Medical Center Nagoya, Japan
    Front Microbiol 2:258. 2011
    ..A3F and A3G are the most potent inhibitors of HIV-1, but only in the absence of the virus-encoded protein, Vif. HIV-1 utilizes Vif to abrogate A3 functions in the producer cells...
  39. pmc Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function
    John S Albin
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Virol 84:10209-19. 2010
    Tandem stop mutations K26X and H27X in human immunodeficiency virus type 1 (HIV-1) vif compromise virus replication in human T-cell lines that stably express APOBEC3F (A3F) or APOBEC3G (A3G)...
  40. pmc The activity spectrum of Vif from multiple HIV-1 subtypes against APOBEC3G, APOBEC3F, and APOBEC3H
    Mawuena Binka
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    J Virol 86:49-59. 2012
    ..The HIV-1 Vif protein counteracts APOBEC3 restriction by mediating its degradation by the proteasome...
  41. pmc Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif
    Elena Britan-Rosich
    Department of Pathology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Mol Biol 410:1065-76. 2011
    In the absence of human immunodeficiency virus type 1 (HIV-1) Vif protein, the host antiviral deaminase apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (A3G) restricts the production of infectious HIV-1 by deamination ..
  42. pmc On the solution conformation and dynamics of the HIV-1 viral infectivity factor
    Sean R Marcsisin
    Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA 02115, USA
    J Mol Biol 410:1008-22. 2011
    ..HIV-1 Vif [viral (also called virion) infectivity factor], one of several HIV accessory proteins, targets APOBEC3 proteins ..
  43. pmc HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation
    Atsushi Okumura
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21231, USA
    Virology 373:85-97. 2008
    ..we show that the degradation is independent of HIV-1 replication and that virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3...
  44. ncbi Natural resistance to HIV infection: The Vif-APOBEC interaction
    Michael H Malim
    Department of Infectious Diseases, King s College London, School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital, London Bridge, London SE1 9RT, UK
    C R Biol 329:871-5. 2006
    ..Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein...
  45. pmc The range of human APOBEC3H sensitivity to lentiviral Vif proteins
    Melody M H Li
    Department of Microbiology, University of Washington, Seattle, USA
    J Virol 84:88-95. 2010
    ..In contrast to human APOBEC3G, which can be completely counteracted by HIV-1 Vif, the protein encoded by APOBEC3H haplotype II is only partially sensitive to Vif, while the protein encoded by ..
  46. pmc Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G
    Guylaine Haché
    Department of Biochemistry, Molecular Biology, and Biophysics, Institute for Molecular Virology, Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Biol 18:819-24. 2008
    The human APOBEC3G protein restricts the replication of Vif-deficient HIV-1 by deaminating nascent viral cDNA cytosines to uracils, leading to viral genomic strand G-to-A hypermutations...
  47. ncbi Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions
    Hongzhan Xu
    Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute Frederick, P O Box B, Bldg 535, Rm 334, Frederick, MD 21702, USA
    Virology 360:247-56. 2007
    ..of human immunodeficiency virus type 1 (HIV-1) by incorporating into virions in the absence of the virally encoded Vif protein (Deltavif virions), at least in part by causing G-to-A hypermutation...
  48. ncbi Phosphorylation of Vif and its role in HIV-1 replication
    X Yang
    Division of Human Retrovirology, Dana Farber Cancer Institute and the Departments of Pathology and Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:10121-9. 1996
    b>Vif is a 23-kDa protein encoded by human immunodeficiency virus, type 1 (HIV-1) which is important for virion infectivity. Here, we describe the phosphorylation of HIV-1 Vif and its role in HIV-1 replication...
  49. pmc Human immunodeficiency virus type 1 Vif functionally interacts with diverse APOBEC3 cytidine deaminases and moves with them between cytoplasmic sites of mRNA metabolism
    Mariana Marin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Virol 82:987-98. 2008
    b>Vif(IIIB), which has been a standard model for the viral infectivity factor of human immunodeficiency virus type 1 (HIV-1), binds the cytidine deaminase APOBEC3G (A3G) and induces its degradation, thereby precluding its lethal ..
  50. pmc A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor
    Hal P Bogerd
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:3770-4. 2004
    The HIV type 1 (HIV-1) virion infectivity factor (Vif) protein blocks the action of the host defense factor APOBEC3G in human cells, thereby allowing release of infectious virions, but fails to inhibit similar APOBEC3G proteins present ..
  51. ncbi The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
    G Hassaine
    INSERM Unit 372, Universite de la Mediterranee, 163 Avenue de Luminy, 13276 Marseilles Cedex 09, France
    J Biol Chem 276:16885-93. 2001
    The virus infectivity factor (Vif) protein facilitates the replication of human immunodeficiency virus type 1 (HIV-1) in primary lymphocytes and macrophages...
  52. pmc The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain
    Sandrina DaFonseca
    Université de Lyon I Claude Bernard, Faculte de Medecine Laennec, Laboratoire de Virologie and Pathologie Humaine, CNRS FRE 3011, 69372 Lyon Cedex 08, France
    Virol J 5:162. 2008
    ....
  53. doi Biophysical characterization of recombinant HIV-1 subtype C virus infectivity factor
    Daniela Gallerano
    Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    Amino Acids 40:981-9. 2011
    HIV-1 virus infectivity factor (Vif) is one of the four accessory proteins that are characteristic of primate lentiviruses and critically required for the infection of host cells...
  54. pmc The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G
    James H Miller
    OyaGen, Inc, 601 Elmwood Ave, Rochester, NY 14642, USA
    Retrovirology 4:81. 2007
    The HIV-1 accessory protein known as viral infectivity factor or Vif binds to the host defence factor human APOBEC3G (hA3G) and prevents its assembly with viral particles and mediates its elimination through ubiquitination and ..
  55. pmc HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes
    Ritu Goila-Gaur
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 0460, USA
    Virology 372:136-46. 2008
    HIV-1 Vif inhibits the antiviral activity of APOBEC3G (APO3G) by inducing proteasomal degradation. Here, we studied the effects of Vif on APO3G in vitro. In this system, Vif did not cause APO3G degradation...
  56. ncbi Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA
    Bin Yang
    Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 282:11667-75. 2007
    ..propose that the degradation of APOBEC3G-edited viral DNA mediated by virion-associated UNG2 and APE during or after reverse transcription could be partially responsible for the potent anti-HIV-1 effect by APOBEC3G in the absence of vif.
  57. ncbi A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action
    Bastien Mangeat
    Department of Microbiology and Molecular Medicine and Frontiers in Genetics Research Program, CMU, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 279:14481-3. 2004
    APOBEC3G (also known as CEM15) is an innate intracellular antiretroviral factor that is counteracted by the Vif protein of lentiviruses...
  58. pmc A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif
    John S Albin
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 285:40785-92. 2010
    ..restricts the infectivity of HIV-1 in the absence of the viral accessory protein virion infectivity factor (Vif)...
  59. doi HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay
    Iris Cadima-Couto
    URIA IMM, Faculdade de Farmácia da Universidade Lisboa, Av das Forcas Armadas, 1649 059 Lisbon, Portugal
    J Neuroimmune Pharmacol 6:296-307. 2011
    The human APOBEC3 (A3) cytidine deaminases, such as APOBEC3G (A3G) and APOBEC3F (A3F), are potent inhibitors of Vif-deficient human immunodeficiency virus type 1 (HIV-1)...
  60. pmc HIV-1 Vif and APOBEC3G: multiple roads to one goal
    Joao Goncalves
    URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, 1649 019 Lisboa, Portugal
    Retrovirology 1:28. 2004
    The viral infectivity factor, Vif, of human immunodeficiency virus type 1, HIV-1, has long been shown to promote viral replication in vivo and to serve a critical function for productive infection of non-permissive cells, like peripheral ..
  61. doi Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction
    Zhiwen He
    Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Zhejiang, China
    J Mol Biol 381:1000-11. 2008
    ..of infectious human immunodeficiency virus (HIV)-1 requires suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through a common mechanism by recruiting Cullin5, ElonginB, and ..
  62. pmc Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation
    Jason L Dehart
    Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East no 2100, Room 2520, Salt Lake City, Utah 84112, USA
    J Virol 82:9265-72. 2008
    Human immunodeficiency virus type 1 (HIV-1) Vif recruits a Cullin 5 ubiquitin ligase that targets APOBEC3 proteins for degradation. Recently, Vif has also been shown to induce cell cycle disturbance in G(2)...
  63. pmc Molecular structure and biochemical properties of the HCCH-Zn2+ site in HIV-1 Vif
    Kalyan Giri
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Biochemistry 48:7969-78. 2009
    Virion infectivity factor (Vif) is an HIV accessory protein that is essential for the infection of CD4(+) T cells...
  64. pmc Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G
    Isabel Uyttendaele
    Department of Medical Protein Research, VIB, Ghent, Belgium
    PLoS ONE 7:e44143. 2012
    ..cytidine deaminase Apobec3G that are important for its homodimerization and its interaction with the HIV-1 Gag and Vif proteins...
  65. doi Effect of HIV-1 Vif variability on progression to pediatric AIDS and its association with APOBEC3G and CUL5 polymorphisms
    Federico A De Maio
    Laboratorio de Biología Celular y Retrovirus CONICET, Hospital de Pediatria Juan P Garrahan, Ciudad de Buenos Aires, Argentina
    Infect Genet Evol 11:1256-62. 2011
    ..The virus has the capacity to counteract this antiviral activity through the expression of the Vif accessory protein, which recruits a CUL5-based ubiquitin ligase complex that determines APOBEC3G proteasomal ..
  66. pmc Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection
    Zhujun Ao
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    PLoS ONE 3:e1995. 2008
    ..During Vif-negative HIV-1 replication, A3G is incorporated into HIV-1 particles, induces mutations in reverse transcribed ..
  67. pmc Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors
    Simon Henriet
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Microbiol Mol Biol Rev 73:211-32. 2009
    The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-1) replication in so-called permissive cells but is required for replication in nonpermissive cell lines and for pathogenesis...
  68. ncbi Role of viral regulatory and accessory proteins in HIV-1 replication
    Anila Seelamgari
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
    Front Biosci 9:2388-413. 2004
    ..HIV-1 replicates actively in a variety of cells by encoding several regulatory (Tat and Rev) and accessory (Vpr, Vif, Vpu, and Nef) proteins...
  69. pmc Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G
    Guylaine Haché
    Department of Biochemistry, Molecular Biology and Biophysics, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Virol 83:5956-60. 2009
    APOBEC3G restricts Vif-deficient human immunodeficiency virus type 1 (HIV-1) by deaminating viral cDNA cytosines to uracils. This promutagenic activity is counteracted by HIV-1 Vif, which is a natural APOBEC3G antagonist...
  70. pmc Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif
    Sean R Marcsisin
    Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA 02115, USA
    J Mol Biol 402:892-904. 2010
    The human immunodeficiency virus type 1 virion infectivity factor (Vif) inhibits the innate viral immunity afforded by the APOBEC3 family of cytidine deaminases...
  71. pmc MDM2 is a novel E3 ligase for HIV-1 Vif
    Taisuke Izumi
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Japan
    Retrovirology 6:1. 2009
    The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G)...
  72. doi Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif
    Bizhan Romani
    Division of Medical Virology, Department of Pathology, University of Stellenbosch, Tygerberg Campus, Tygerberg, South Africa
    Arch Virol 154:1579-88. 2009
    ..In the absence of human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif), APOBEC3G and APOBEC3F are incorporated into HIV-1 virions and hypermutate the viral genomic DNA by their cytidine ..
  73. pmc Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif
    Qiujia Shao
    Center for AIDS Health Disparities Research, School of Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Virol 84:4840-4. 2010
    ..In this study, we showed that although macaque simian immunodeficiency virus (SIVmac) Vif is more stable than HIV-1 Vif in human cells, SIVmac Vif induces degradation of APBOEC3G as efficiently as HIV-1 ..
  74. pmc Identification of 81LGxGxxIxW89 and 171EDRW174 domains from human immunodeficiency virus type 1 Vif that regulate APOBEC3G and APOBEC3F neutralizing activity
    Ying Dang
    Department of Microbiology, Michigan State University, East Lansing, MI 48824 4320, USA
    J Virol 84:5741-50. 2010
    ..restrict human immunodeficiency virus type 1 (HIV-1) replication, but they are neutralized by the viral protein Vif. Vif bridges A3G and A3F with a Cullin 5 (Cul5)-based E3 ubiquitin ligase and mediates their proteasomal ..
  75. pmc Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines
    Yunkai Yu
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Genes Dev 18:2867-72. 2004
    APOBEC3G, which induces hypermutations in newly synthesized viral DNA, is suppressed by HIV-1 Vif, acting through Cul5-ElonginB-ElonginC E3 ubiquitin ligase...
  76. ncbi Function analysis of sequences in human APOBEC3G involved in Vif-mediated degradation
    Li Zhang
    Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    Virology 370:113-21. 2008
    Human APOBEC3G (hA3G) has been identified as an anti-HIV cellular factor. As a counter measure, the HIV-1 protein Vif causes the degradation of hA3G by binding to it and directing it to the cellular proteasome...
  77. pmc Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity
    Gang Peng
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:41-6. 2006
    ..As a counterattack, HIV virion infectivity factor (Vif) targets APOBEC3G for proteasomal proteolysis to exclude it from budding virions...
  78. pmc Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions
    A Billich
    Sandoz Forschungsinstitut GmbH, Vienna, Austria
    J Virol 69:2451-61. 1995
    ..Cyclophilin A also binds to HIV-1 proteins other than gag-encoded proteins, namely, p17gag, Nef, Vif, and gp120env; the biological significance of these interactions is questionable...
  79. pmc Differential sensitivity of "old" versus "new" APOBEC3G to human immunodeficiency virus type 1 vif
    Ritu Goila-Gaur
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 0460, USA
    J Virol 83:1156-60. 2009
    HIV-1 Vif counteracts the antiviral activity of APOBEC3G by inhibiting its encapsidation into virions...
  80. doi Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
    Kotaro Shirakawa
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Nat Struct Mol Biol 15:1184-91. 2008
    ..HIV-1 viral infectivity factor (Vif) counteracts A3G by promoting its degradation via the ubiquitin-proteasome pathway...
  81. pmc Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif
    Rebecca A Russell
    Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Virol 83:1992-2003. 2009
    Human APOBEC3G (A3G) and APOBEC3F (A3F) inhibit the replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their degradation...
  82. pmc Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin
    B Martoglio
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Postfach 106249, 69052 Heidelberg, Germany
    EMBO J 16:6636-45. 1997
    ..The functional consequences of such interactions remain to be established. However, our data suggest that signal sequences may be functionally more versatile than anticipated up to now...
  83. pmc Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F
    Chunjuan Tian
    Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou, China
    J Virol 80:3112-5. 2006
    ..of infectious human immunodeficiency virus type 1 (HIV-1) requires suppression of multiple cytidine deaminases by Vif. Whether HIV-1 Vif recognizes various APOBEC3 proteins through a common mechanism is unclear...
  84. pmc Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif
    Feng Feng
    Australian Centre for Hepatitis and HIV Virology Research, Infectious Disease Laboratories, Institute of Medical and Veterinary Science, Frome Rd, Adelaide, Australia 5000
    J Virol 78:10574-81. 2004
    Virion infectivity factor (Vif) protein of human immunodeficiency virus type 1 (HIV-1) is essential for the productive infection of primary human CD4 T lymphocytes and macrophages...
  85. ncbi HIV-1 tat protein and cell proliferation and survival: a brief review
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Italy
    New Microbiol 28:95-109. 2005
    ..This review focuses on some aspects of Tat biological activity with particular regard to effects of Tat on cell proliferation and survival regulation...
  86. ncbi Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation
    Melissa A Farrow
    Program in Molecular Medicine and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    AIDS Res Hum Retroviruses 21:565-74. 2005
    Recent reports have determined that HIV-1 Vif counteracts an innate antiviral cellular factor, Apobec3G. However, the function of Vif during HIV-1 pathogenesis remains poorly understood...
  87. ncbi Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function
    Masayuki Kobayashi
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 280:18573-8. 2005
    The human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif) overcomes the antiviral activity of APOBEC3G to protect HIV-1 DNA from G-to-A hypermutation...
  88. ncbi HIV-1 TAR RNA: the target of molecular interactions between the virus and its host
    Sylvie Bannwarth
    McGill University AIDS Centre, Molecular Oncology Group, Lady Davis Institute for Medical Research, Canada
    Curr HIV Res 3:61-71. 2005
    ..Recent data using small molecules or RNA-based technologies show that acting on the TAR RNA or on its viral and cellular binding factors effectively decreases virion production...
  89. ncbi APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo
    Mark T Liddament
    University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, 321 Church St S E, 6 155 Jackson Hall, Minneapolis, MN 55455, USA
    Curr Biol 14:1385-91. 2004
    ..also a potent retroviral restrictor but that its activity, unlike that of APOBEC3G, is partially resistant to HIV-1 Vif and results in a clear 5'-GA --> -AA retroviral hypermutation preference...
  90. ncbi New insights into the role of Vif in HIV-1 replication
    Bärbel Schröfelbauer
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    AIDS Rev 6:34-9. 2004
    HIV-1 and most of the other lentiviruses encode Vif (virion infectivity factor), an accessory protein that the virus requires to replicate in primary CD4+ T-cells and monocytes...
  91. ncbi Functional domains of APOBEC3G required for antiviral activity
    Jinliang Li
    Molecular Virology Division, St Luke s Roosevelt Hospital Center and Columbia University, New York, New York 10019, USA
    J Cell Biochem 92:560-72. 2004
    The viral protein, Vif, is essential for the production of infectious progeny virions in natural target cells of human immunodeficiency virus type 1 (HIV-1)...
  92. pmc Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication
    Yong Hui Zheng
    Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, 3rd and Parnassus Ave, San Francisco, CA 94143 0703, USA
    J Virol 78:6073-6. 2004
    ..Similar to APOBEC3G, APOBEC3F also induced G to A hypermutations in HIV genomic DNA, and the viral Vif protein counteracted its activity...
  93. ncbi The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitin
    Sylvie Dussart
    INSERM Unit 372, Universite de la Mediterranee, 163 Avenue de Luminy, BP178, 13276 Marseille Cedex 09, France
    Biochem Biophys Res Commun 315:66-72. 2004
    The viral infectivity factor (Vif), one of the six HIV-1 auxiliary genes, is absolutely necessary for productive infection in primary CD4-positive T lymphocytes and macrophages...
  94. pmc Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1
    Navid Madani
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    J Virol 76:11133-8. 2002
    The viral infectivity factor (Vif) of human immunodeficiency virus type 1 (HIV-1) neutralizes an unidentified antiviral pathway that occurs only in nonpermissive (NP) cells...
  95. pmc Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts
    D H Nguyen
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 74:3264-72. 2000
    ....
  96. ncbi Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif
    Zuoxiang Xiao
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Virology 349:290-9. 2006
    APOBEC3G (A3G) and related cytidine deaminases are potent inhibitors of retroviruses. HIV-1 Vif hijacks the cellular Cul5-E3 ubiquitin ligase to degrade APOBEC3 proteins and render them ineffective against these viruses...
  97. pmc Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G binding
    Andrew Mehle
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 81:13235-41. 2007
    ..HIV-1 Vif binds APOBEC3G and APOBEC3F and targets these proteins for ubiquitination by forming an E3 ubiquitin ligase with ..
  98. pmc Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription
    S Henriet
    Architecture et Reactivite de l ARN, Universite Louis Pasteur, CNRS, IBMC, 15 rue Rene Descartes, 67084, Strasbourg Cedex, France
    Nucleic Acids Res 35:5141-53. 2007
    HIV-1 Vif (viral infectivity factor) is associated with the assembly complexes and packaged at low level into the viral particles, and is essential for viral replication in non-permissive cells...
  99. pmc Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family
    Ying Dang
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824 4320, USA
    J Virol 80:10522-33. 2006
    ..In opposition to APOBEC genes, HIV-1 and SIV contain a virion infectivity factor (Vif) that targets APOBEC3F and APOBEC3G for polyubiquitylation and proteasomal degradation...
  100. pmc Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F
    Rebecca A Russell
    HIV Drug Resistance Program, National Cancer Institute Frederick, P O Box B, Bldg 535, Rm 334, Frederick, MD 21702 1201, USA
    J Virol 81:8201-10. 2007
    Human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) inhibit replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1)...
  101. pmc Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant
    Sandrine Opi
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892 0460, USA
    J Virol 81:8236-46. 2007
    Human immunodeficiency virus type 1 (HIV-1) Vif counteracts the antiviral activity of the human cytidine deaminase APOBEC3G (APO3G) by inhibiting its incorporation into virions...

Research Grants53

  1. DELETION MUTAGENESIS WITHIN NONCODING SEGMENTS OF HIV1
    Mark Wainberg; Fiscal Year: 2001
    ..6. To determine whether these attenuated SIV constructs may protect against subsequent challenge with virulent forms of SIV and SIV/HIV hybrids. ..
  2. Mechanisms involved in HIV-1 Tat mediated neuronal damage
    Francesca Peruzzi; Fiscal Year: 2007
    ..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
  3. Regulation of human microRNA biosynthesis and activity
    BRYAN CULLEN; Fiscal Year: 2007
    ..Finally, in specific aim 5, we seek to extend our exciting initial data demonstrating inhibition of miRNA function by the adenovirus VA1 non-coding RNA by trying to define the underlying mechanism. ..
  4. Role and mechanism of action of Gamma herpesvirus microRNAs
    BRYAN CULLEN; Fiscal Year: 2007
    ..Together, these studies should identify human mRNA targets for several KSHV and EBV miRNAs and shed light on the role of these miRNAs in the replication cycle of Gamma herpesviruses in general. ..
  5. Peptide Inhibitors of HIV-1 Vif Function
    John Donahue; Fiscal Year: 2007
    ..One example of this kind of interaction occurs between the HIV-1 Vif protein and the host cell cytidine deaminase, APOBEC3G...
  6. Molecular basis of neuronal dysfunction in AIDS
    Francesca Peruzzi; Fiscal Year: 2007
    ..The outcome of these studies will provide a new information on the pathways which are affected by HIV-1 Tat, and will assist to improve our effort for developing strategies against HIV-1 induced neuronal cell injury. ..
  7. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2007
    ..abstract_text> ..
  8. Molecular Mechanism of HIV-1 Vif Function
    BRYAN CULLEN; Fiscal Year: 2007
    Although expression of the viral Vif protein is critical for HIV-1 replication in primary cells, the mechanism of action of Vif has, until recently, been largely unclear...
  9. HIV-1: microRNA interactions
    Bryan R Cullen; Fiscal Year: 2010
    ..This research has the potential to not only shed new light on HIV-1 pathogenesis but also suggest new approaches to inhibit virus replication. ..
  10. Role and mechanism of action of Gamma herpesvirus microRNAs
    Bryan R Cullen; Fiscal Year: 2010
    ..Together, these studies should identify human mRNA targets for several KSHV and EBV miRNAs and shed light on the role of these miRNAs in the replication cycle of Gamma herpesviruses in general. ..
  11. Mechanisms involved in HIV-1 Tat mediated neuronal damage
    Francesca Peruzzi; Fiscal Year: 2010
    ..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
  12. Effect of APOBEC3G on retroviruses and retrotransposons
    BRYAN CULLEN; Fiscal Year: 2009
    ..and other related APOBEC3 proteins, on HIV-1 replication but also the mechanism of APOBEC3G neutralization by HIV-1 Vif. However, the APOBEC3 protein family must be evolutionarily conserved in humans for reasons unrelated to HIV-1 ..
  13. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2006
    ..abstract_text> ..
  14. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2003
    ..abstract_text> ..
  15. HIV-1 TROPISM AND CHEMOKINE RECEPTORS
    BRYAN CULLEN; Fiscal Year: 2002
    ..The final specific aim focusses on the promoter regions of CCR5, the identification of transcription factors that may interact with the promoter, and the use of antisense strategies to block CCR5 expression. ..
  16. Cell Cycle G2/M Pathway Modulated by Viral Protein R
    Richard Zhao; Fiscal Year: 2006
    ..These proposed studies will provide a comprehensive framework for this new cell cycle control pathway and provide insights into fundamental aspects of this new G2/M surveillance system of eukaryotic cells. ..