Research Topics
Genomes and Genes
| vifSummaryGene Symbol: vif Description: p23 Alias: Vif Species: Human immunodeficiency virus 1 Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Fully functional, naturally occurring and C-terminally truncated variant human immunodeficiency virus (HIV) Vif does not bind to HIV Gag but influences intermediate filament structureT Henzler
Forschungsschwerpunkt Angewandte Tumorvirologie, F0200, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
J Gen Virol 82:561-73. 2001A variant human immunodeficiency virus type 1 (HIV-1) vif gene, vifA45-2, which encodes a protein lacking 19 amino acids at the C terminus but which is fully functional in supporting HIV replication in non-permissive cells has been ..
Production of infectious virus and degradation of APOBEC3G are separable functional properties of human immunodeficiency virus type 1 VifSandra Kao
Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bldg 4, Room 310, 4 Center Drive MSC 0460, Bethesda, MD 20892 0460, USA
Virology 369:329-39. 2007HIV-1 Vif regulates viral infectivity by inhibiting the encapsidation of APOBEC3G (APO3G) through proteasomal degradation of the protein...- RNA and DNA binding properties of HIV-1 Vif protein: a fluorescence studySerena Bernacchi
Architecture et Reactivite de l ARN, Universite Louis Pasteur de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg, France
J Biol Chem 282:26361-8. 2007The HIV-1 viral infectivity factor (Vif) is a small basic protein essential for viral fitness and pathogenicity. Some "non-permissive" cell lines cannot sustain replication of Vif(-) HIV-1 virions... - Identification of amino acid residues in APOBEC3G required for regulation by human immunodeficiency virus type 1 Vif and Virion encapsidationHendrik Huthoff
Department of Infectious Diseases, King s College London School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital, London Bridge, London SE1 9RT, United Kingdom
J Virol 81:3807-15. 2007The human immunodeficiency virus type-1 (HIV-1) accessory protein Vif serves to neutralize the human antiviral proteins apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G [A3G]) and A3F... - Multifaceted antiviral actions of APOBEC3 cytidine deaminasesYa Lin Chiu
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, USA
Trends Immunol 27:291-7. 2006..Insights into how the action of A3G is circumvented by HIV-1 through the action of its Vif protein, and the surprising mechanisms by which A3G is regulated within the cell, offer exciting new opportunities .. - Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradationJason L Dehart
Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East no 2100, Room 2520, Salt Lake City, Utah 84112, USA
J Virol 82:9265-72. 2008Human immunodeficiency virus type 1 (HIV-1) Vif recruits a Cullin 5 ubiquitin ligase that targets APOBEC3 proteins for degradation. Recently, Vif has also been shown to induce cell cycle disturbance in G(2)... - A single amino acid in human APOBEC3F alters susceptibility to HIV-1 VifJohn S Albin
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 285:40785-92. 2010..restricts the infectivity of HIV-1 in the absence of the viral accessory protein virion infectivity factor (Vif)... - HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradationAtsushi Okumura
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21231, USA
Virology 373:85-97. 2008..we show that the degradation is independent of HIV-1 replication and that virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3... - The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domainSandrina DaFonseca
Université de Lyon I Claude Bernard, Faculte de Medecine Laennec, Laboratoire de Virologie and Pathologie Humaine, CNRS FRE 3011, 69372 Lyon Cedex 08, France
Virol J 5:162. 2008.... 
Effect of HIV-1 Vif variability on progression to pediatric AIDS and its association with APOBEC3G and CUL5 polymorphismsFederico A De Maio
Laboratorio de Biología Celular y Retrovirus CONICET, Hospital de Pediatria Juan P Garrahan, Ciudad de Buenos Aires, Argentina
Infect Genet Evol 11:1256-62. 2011..The virus has the capacity to counteract this antiviral activity through the expression of the Vif accessory protein, which recruits a CUL5-based ubiquitin ligase complex that determines APOBEC3G proteasomal ..- Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infectionZhujun Ao
Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
PLoS ONE 3:e1995. 2008..During Vif-negative HIV-1 replication, A3G is incorporated into HIV-1 particles, induces mutations in reverse transcribed .. - Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteinsWenyan Zhang
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
PLoS ONE 3:e3963. 2008..Formation of infectious HIV-1 requires the suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through the common mechanism of recruiting the Cullin5-ElonginB-.. - Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factorsSimon Henriet
Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
Microbiol Mol Biol Rev 73:211-32. 2009The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-1) replication in so-called permissive cells but is required for replication in nonpermissive cell lines and for pathogenesis... - Role of viral regulatory and accessory proteins in HIV-1 replicationAnila Seelamgari
Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA
Front Biosci 9:2388-413. 2004..HIV-1 replicates actively in a variety of cells by encoding several regulatory (Tat and Rev) and accessory (Vpr, Vif, Vpu, and Nef) proteins... - Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3GGuylaine Haché
Department of Biochemistry, Molecular Biology and Biophysics, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Virol 83:5956-60. 2009APOBEC3G restricts Vif-deficient human immunodeficiency virus type 1 (HIV-1) by deaminating viral cDNA cytosines to uracils. This promutagenic activity is counteracted by HIV-1 Vif, which is a natural APOBEC3G antagonist... - A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3GGongying Chen
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
J Virol 83:8674-82. 2009The amino-terminal region of the Vif molecule in human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV) contains a conserved SLV/Ix4Yx9Y motif that was first described in 1992, but the importance of .. - Antiviral roles of APOBEC proteins against HIV-1 and suppression by VifBizhan Romani
Division of Medical Virology, Department of Pathology, University of Stellenbosch, Tygerberg Campus, Tygerberg, South Africa
Arch Virol 154:1579-88. 2009..In the absence of human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif), APOBEC3G and APOBEC3F are incorporated into HIV-1 virions and hypermutate the viral genomic DNA by their cytidine .. - HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translationGaëlle Mercenne
Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084, Strasbourg Cedex, France
Nucleic Acids Res 38:633-46. 2010The HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells (including most natural HIV-1 targets) by counteracting the cellular cytosine deaminases APOBEC-3G (hA3G) and hA3F... - A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivityAnjie Zhen
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
J Virol 84:1902-11. 2010..However, it is not clear whether HIV-1 Vif can recognize and suppress the antiviral activity of A3H variants, as it does with other APOBEC3 proteins... - Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 VifQiujia Shao
Center for AIDS Health Disparities Research, School of Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
J Virol 84:4840-4. 2010..In this study, we showed that although macaque simian immunodeficiency virus (SIVmac) Vif is more stable than HIV-1 Vif in human cells, SIVmac Vif induces degradation of APBOEC3G as efficiently as HIV-1 .. - Identification of 81LGxGxxIxW89 and 171EDRW174 domains from human immunodeficiency virus type 1 Vif that regulate APOBEC3G and APOBEC3F neutralizing activityYing Dang
Department of Microbiology, Michigan State University, East Lansing, MI 48824 4320, USA
J Virol 84:5741-50. 2010..restrict human immunodeficiency virus type 1 (HIV-1) replication, but they are neutralized by the viral protein Vif. Vif bridges A3G and A3F with a Cullin 5 (Cul5)-based E3 ubiquitin ligase and mediates their proteasomal .. - Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 VifSean R Marcsisin
Department of Chemistry and Chemical Biology and the Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA 02115, USA
J Mol Biol 402:892-904. 2010The human immunodeficiency virus type 1 virion infectivity factor (Vif) inhibits the innate viral immunity afforded by the APOBEC3 family of cytidine deaminases... - MDM2 is a novel E3 ligase for HIV-1 VifTaisuke Izumi
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo ku, Japan
Retrovirology 6:1. 2009The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G)... - Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activityGang Peng
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:41-6. 2006..As a counterattack, HIV virion infectivity factor (Vif) targets APOBEC3G for proteasomal proteolysis to exclude it from budding virions... - Vif-deficient HIV reverse transcription complexes (RTCs) are subject to structural changes and mutation of RTC-associated reverse transcription productsJ M Carr
Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia
Virology 351:80-91. 2006..WT and Vif-deficient (Deltavif) RTCs produced by infection with virus from permissive cells displayed similar sedimentation .. - Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNABin Yang
Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 282:11667-75. 2007..propose that the degradation of APOBEC3G-edited viral DNA mediated by virion-associated UNG2 and APE during or after reverse transcription could be partially responsible for the potent anti-HIV-1 effect by APOBEC3G in the absence of vif. - Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variantSandrine Opi
Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892 0460, USA
J Virol 81:8236-46. 2007Human immunodeficiency virus type 1 (HIV-1) Vif counteracts the antiviral activity of the human cytidine deaminase APOBEC3G (APO3G) by inhibiting its incorporation into virions... - Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virionsHongzhan Xu
Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute Frederick, P O Box B, Bldg 535, Rm 334, Frederick, MD 21702, USA
Virology 360:247-56. 2007..of human immunodeficiency virus type 1 (HIV-1) by incorporating into virions in the absence of the virally encoded Vif protein (Deltavif virions), at least in part by causing G-to-A hypermutation... - Generation of simian-tropic HIV-1 by restriction factor evasionTheodora Hatziioannou
Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA
Science 314:95. 2006.... - Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC familyYing Dang
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824 4320, USA
J Virol 80:10522-33. 2006..In opposition to APOBEC genes, HIV-1 and SIV contain a virion infectivity factor (Vif) that targets APOBEC3F and APOBEC3G for polyubiquitylation and proteasomal degradation... - Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3GBärbel Schröfelbauer
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
J Virol 80:5984-91. 2006..as human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) have evolved the accessory protein Vif to induce their degradation before packaging... - Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1Navid Madani
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
J Virol 76:11133-8. 2002The viral infectivity factor (Vif) of human immunodeficiency virus type 1 (HIV-1) neutralizes an unidentified antiviral pathway that occurs only in nonpermissive (NP) cells... - Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in VifZuoxiang Xiao
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Virology 349:290-9. 2006APOBEC3G (A3G) and related cytidine deaminases are potent inhibitors of retroviruses. HIV-1 Vif hijacks the cellular Cul5-E3 ubiquitin ligase to degrade APOBEC3 proteins and render them ineffective against these viruses... - Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3FChunjuan Tian
Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou, China
J Virol 80:3112-5. 2006..of infectious human immunodeficiency virus type 1 (HIV-1) requires suppression of multiple cytidine deaminases by Vif. Whether HIV-1 Vif recognizes various APOBEC3 proteins through a common mechanism is unclear... - Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3FRebecca A Russell
HIV Drug Resistance Program, National Cancer Institute Frederick, P O Box B, Bldg 535, Rm 334, Frederick, MD 21702 1201, USA
J Virol 81:8201-10. 2007Human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) inhibit replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1)... - Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 VifRebecca A Russell
Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
J Virol 83:1992-2003. 2009Human APOBEC3G (A3G) and APOBEC3F (A3F) inhibit the replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their degradation... - Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 VifKotaro Shirakawa
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
Nat Struct Mol Biol 15:1184-91. 2008..HIV-1 viral infectivity factor (Vif) counteracts A3G by promoting its degradation via the ubiquitin-proteasome pathway... - Identification of amino acid residues in HIV-1 Vif critical for binding and exclusion of APOBEC3G/FTomoki Yamashita
Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
Microbes Infect 10:1142-9. 2008To define a region(s) in human immunodeficiency virus type 1 (HIV-1) Vif that involves binding to its target APOBEC3G (A3G), we have generated a series of site-specific proviral vif mutants... - Differential sensitivity of "old" versus "new" APOBEC3G to human immunodeficiency virus type 1 vifRitu Goila-Gaur
Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 0460, USA
J Virol 83:1156-60. 2009HIV-1 Vif counteracts the antiviral activity of APOBEC3G by inhibiting its encapsidation into virions... - Human immunodeficiency virus type 1 Vif functionally interacts with diverse APOBEC3 cytidine deaminases and moves with them between cytoplasmic sites of mRNA metabolismMariana Marin
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 3098, USA
J Virol 82:987-98. 2008b>Vif(IIIB), which has been a standard model for the viral infectivity factor of human immunodeficiency virus type 1 (HIV-1), binds the cytidine deaminase APOBEC3G (A3G) and induces its degradation, thereby precluding its lethal .. - Function analysis of sequences in human APOBEC3G involved in Vif-mediated degradationLi Zhang
Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
Virology 370:113-21. 2008Human APOBEC3G (hA3G) has been identified as an anti-HIV cellular factor. As a counter measure, the HIV-1 protein Vif causes the degradation of hA3G by binding to it and directing it to the cellular proteasome... - Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G bindingAndrew Mehle
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Virol 81:13235-41. 2007..HIV-1 Vif binds APOBEC3G and APOBEC3F and targets these proteins for ubiquitination by forming an E3 ubiquitin ligase with .. - Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcriptionS Henriet
Architecture et Reactivite de l ARN, Universite Louis Pasteur, CNRS, IBMC, 15 rue Rene Descartes, 67084, Strasbourg Cedex, France
Nucleic Acids Res 35:5141-53. 2007HIV-1 Vif (viral infectivity factor) is associated with the assembly complexes and packaged at low level into the viral particles, and is essential for viral replication in non-permissive cells... - Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminasesWenyan Zhang
College of Life Science, Jilin University, Changchun 130021, China
Cell Microbiol 10:1662-75. 2008..deaminase APOBEC3C (A3C) acts as a potent inhibitor of SIVagm and can be regulated by both HIV-1 and SIVagm Vif. The mechanism by which Vif suppresses A3C is unknown... - Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulinB Martoglio
Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Postfach 106249, 69052 Heidelberg, Germany
EMBO J 16:6636-45. 1997..The functional consequences of such interactions remain to be established. However, our data suggest that signal sequences may be functionally more versatile than anticipated up to now... - HIV-1 Vif and APOBEC3G: multiple roads to one goalJoao Goncalves
URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, 1649 019 Lisboa, Portugal
Retrovirology 1:28. 2004The viral infectivity factor, Vif, of human immunodeficiency virus type 1, HIV-1, has long been shown to promote viral replication in vivo and to serve a critical function for productive infection of non-permissive cells, like peripheral .. - Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cellsSandra Kao
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
Retrovirology 1:27. 2004The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions... - Ring finger protein ZIN interacts with human immunodeficiency virus type 1 VifFeng Feng
Australian Centre for Hepatitis and HIV Virology Research, Infectious Disease Laboratories, Institute of Medical and Veterinary Science, Frome Rd, Adelaide, Australia 5000
J Virol 78:10574-81. 2004Virion infectivity factor (Vif) protein of human immunodeficiency virus type 1 (HIV-1) is essential for the productive infection of primary human CD4 T lymphocytes and macrophages... - APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivoMark T Liddament
University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, 321 Church St S E, 6 155 Jackson Hall, Minneapolis, MN 55455, USA
Curr Biol 14:1385-91. 2004..also a potent retroviral restrictor but that its activity, unlike that of APOBEC3G, is partially resistant to HIV-1 Vif and results in a clear 5'-GA --> -AA retroviral hypermutation preference... - New insights into the role of Vif in HIV-1 replicationBärbel Schröfelbauer
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
AIDS Rev 6:34-9. 2004HIV-1 and most of the other lentiviruses encode Vif (virion infectivity factor), an accessory protein that the virus requires to replicate in primary CD4+ T-cells and monocytes... - Functional domains of APOBEC3G required for antiviral activityJinliang Li
Molecular Virology Division, St Luke s Roosevelt Hospital Center and Columbia University, New York, New York 10019, USA
J Cell Biochem 92:560-72. 2004The viral protein, Vif, is essential for the production of infectious progeny virions in natural target cells of human immunodeficiency virus type 1 (HIV-1)... - A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factorHal P Bogerd
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 101:3770-4. 2004The HIV type 1 (HIV-1) virion infectivity factor (Vif) protein blocks the action of the host defense factor APOBEC3G in human cells, thereby allowing release of infectious virions, but fails to inhibit similar APOBEC3G proteins present .. - Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replicationYong Hui Zheng
Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, 3rd and Parnassus Ave, San Francisco, CA 94143 0703, USA
J Virol 78:6073-6. 2004..Similar to APOBEC3G, APOBEC3F also induced G to A hypermutations in HIV genomic DNA, and the viral Vif protein counteracted its activity... - The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitinSylvie Dussart
INSERM Unit 372, Universite de la Mediterranee, 163 Avenue de Luminy, BP178, 13276 Marseille Cedex 09, France
Biochem Biophys Res Commun 315:66-72. 2004The viral infectivity factor (Vif), one of the six HIV-1 auxiliary genes, is absolutely necessary for productive infection in primary CD4-positive T lymphocytes and macrophages... - Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathwayAndrew Mehle
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Biol Chem 279:7792-8. 2004Viruses must overcome diverse intracellular defense mechanisms to establish infection. The Vif (virion infectivity factor) protein of human immunodeficiency virus 1 (HIV-1) acts by overcoming the antiviral activity of APOBEC3G (CEM15), a .. - Identification of a host protein essential for assembly of immature HIV-1 capsidsConcepcion Zimmerman
Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
Nature 415:88-92. 2002..Furthermore, in cells the HP68-Gag complex is associated with HIV-1 Vif, which is involved in virion morphogenesis and infectivity... - The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif proteinG Hassaine
INSERM Unit 372, Universite de la Mediterranee, 163 Avenue de Luminy, 13276 Marseilles Cedex 09, France
J Biol Chem 276:16885-93. 2001The virus infectivity factor (Vif) protein facilitates the replication of human immunodeficiency virus type 1 (HIV-1) in primary lymphocytes and macrophages... - Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid raftsD H Nguyen
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 74:3264-72. 2000.... - Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteinesYunkai Yu
Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Genes Dev 18:2867-72. 2004APOBEC3G, which induces hypermutations in newly synthesized viral DNA, is suppressed by HIV-1 Vif, acting through Cul5-ElonginB-ElonginC E3 ubiquitin ligase... - HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradationMariana Santa-Marta
Unidade de Retrovirus e Infecçôes Associadas, Centro de Patogenese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Av das Forcas Armadas, 1649 019 Lisboa, Portugal
J Biol Chem 280:8765-75. 2005..HIV-1 viral infectivity factor (Vif) protein was shown to protect the virus from APOBEC3G-mediated viral cDNA hypermutation... - Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactionsA Billich
Sandoz Forschungsinstitut GmbH, Vienna, Austria
J Virol 69:2451-61. 1995..Cyclophilin A also binds to HIV-1 proteins other than gag-encoded proteins, namely, p17gag, Nef, Vif, and gp120env; the biological significance of these interactions is questionable... - Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif functionMasayuki Kobayashi
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
J Biol Chem 280:18573-8. 2005The human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif) overcomes the antiviral activity of APOBEC3G to protect HIV-1 DNA from G-to-A hypermutation... - Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuationMelissa A Farrow
Program in Molecular Medicine and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
AIDS Res Hum Retroviruses 21:565-74. 2005Recent reports have determined that HIV-1 Vif counteracts an innate antiviral cellular factor, Apobec3G. However, the function of Vif during HIV-1 pathogenesis remains poorly understood... - HIV-1 tat protein and cell proliferation and survival: a brief reviewDavide Gibellini
Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Italy
New Microbiol 28:95-109. 2005..This review focuses on some aspects of Tat biological activity with particular regard to effects of Tat on cell proliferation and survival regulation... - HIV-1 TAR RNA: the target of molecular interactions between the virus and its hostSylvie Bannwarth
McGill University AIDS Centre, Molecular Oncology Group, Lady Davis Institute for Medical Research, Canada
Curr HIV Res 3:61-71. 2005..Recent data using small molecules or RNA-based technologies show that acting on the TAR RNA or on its viral and cellular binding factors effectively decreases virion production... - Regulation of Vif mRNA splicing by human immunodeficiency virus type 1 requires 5' splice site D2 and an exonic splicing enhancer to counteract cellular restriction factor APOBEC3GDibyakanti Mandal
Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
J Virol 83:6067-78. 2009The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif is encoded by an incompletely spliced mRNA resulting from splicing of the major splice donor in the HIV-1 genome, 5' splice site (5'ss) D1, to the first splice .. - The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrestKeiko Sakai
Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
Proc Natl Acad Sci U S A 103:3369-74. 2006..However, elimination of the vif and vpr accessory genes together, but not individually, renders the virus incapable of causing cell death and G(2) .. - Role of the non-homologous DNA end joining pathway in the early steps of retroviral infectionL Li
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
EMBO J 20:3272-81. 2001..We propose that the double-strand ends present in unintegrated cDNA promote apoptosis, as is known to be the case for chromosomal double-strand breaks, and cDNA circularization removes the pro-apoptotic signal... - HIV-1 Vif: HIV's weapon against the cellular defense factor APOBEC3GMelanie Kremer
Department of Virology, Paul Ehrlich Institut, Langen, Germany
Curr HIV Res 3:339-44. 2005The human immunodeficiency virus type 1, HIV-1, has long been known to possess the viral infectivity factor, Vif, which supports productive viral replication in non-permissive cells, such as peripheral blood lymphocytes (PBL)... - The role of Vif during HIV-1 infection: interaction with novel host cellular factorsJulie Anne Lake
National Centre for HIV Virology Research, Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Frome Road, Adelaide 5000, Australia
J Clin Virol 26:143-52. 2003Current research suggests that human immunodeficiency virus type-1 (HIV-1) virion infectivity factor (Vif) acts during viral assembly in producer cells to ensure infectivity in target cells but the exact mechanism of action has not been .. - APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanismRaffaella Franca
Istituto di Genetica Molecolare IGM CNR, Pavia, Italy
Med Sci Monit 12:RA92-8. 2006..This natural antiretroviral host defense mechanism is counteracted by the HIV-1 protein Vif, which is able to target APOBECs to degrade... - Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralizationYing Dang
Department of Microbiology, Michigan State University, East Lansing, Michigan 48824 4320, USA
J Virol 83:8544-52. 2009The function of lentiviral Vif proteins is to neutralize the host antiviral cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F)... - The range of human APOBEC3H sensitivity to lentiviral Vif proteinsMelody M H Li
Department of Microbiology, University of Washington, Seattle, USA
J Virol 84:88-95. 2010..In contrast to human APOBEC3G, which can be completely counteracted by HIV-1 Vif, the protein encoded by APOBEC3H haplotype II is only partially sensitive to Vif, while the protein encoded by .. - Interactions in vivo between the Vif protein of HIV-1 and the precursor (Pr55(GAG)) of the virion nucleocapsid proteinsFarhatullah Syed
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
Arch Virol 154:1797-805. 2009The abnormality of viral core structure seen in vif-defective HIV-1 grown in PBMCs has suggested a role for Vif in viral morphogenesis... - Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factorsBryan R Cullen
Department of Molecular Genetics and Microbiology, Box 3025, Duke University Medical Center, Durham, NC 27710, USA
J Virol 80:1067-76. 2006 - [Vimentin intermediate filaments are involved in replication of human immunodeficiency virus type I]T V Khakhulina
Dokl Akad Nauk 368:706-8. 1999 - Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif proteinX Yang
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Biol Chem 273:29879-87. 1998The human immunodeficiency virus type 1 (HIV-1) Vif protein plays a critical role in virus replication and infectivity. Here we show that Vif is phosphorylated and regulated by p44/42 mitogen-activated protein kinase (MAPK)... - The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cellsJ H Simon
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104 6148, USA
J Virol 71:5259-67. 1997The Vif protein of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses is required for efficient replication in primary cells and certain immortalized cell lines in vitro and, in all likelihood, for the establishment of .. - Phosphorylation of Vif and its role in HIV-1 replicationX Yang
Division of Human Retrovirology, Dana Farber Cancer Institute and the Departments of Pathology and Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 271:10121-9. 1996b>Vif is a 23-kDa protein encoded by human immunodeficiency virus, type 1 (HIV-1) which is important for virion infectivity. Here, we describe the phosphorylation of HIV-1 Vif and its role in HIV-1 replication... - The multiple functions of HIV-1 Tat: proliferation versus apoptosisFrancesca Peruzzi
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
Front Biosci 11:708-17. 2006..Here, we discuss intracellular activities of Tat in HIV-infected cells, as well as in cells exposed to Tat, and focus on two contradictory aspects of Tat-mediated effects: cell proliferation and cell death... - High level expression of human immunodeficiency virus type-1 Vif inhibits viral infectivity by modulating proteolytic processing of the Gag precursor at the p2/nucleocapsid processing siteHirofumi Akari
Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, 4 312, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
J Biol Chem 279:12355-62. 2004The human immunodeficiency virus type-1 Vif protein has a crucial role in regulating viral infectivity. However, we found that newly synthesized Vif is rapidly degraded by cellular proteases... - Cytidine deamination induced HIV-1 drug resistanceLubbertus C F Mulder
Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1090, New York, NY 10029, USA
Proc Natl Acad Sci U S A 105:5501-6. 2008The HIV-1 Vif protein is essential for overcoming the antiviral activity of DNA-editing apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) cytidine deaminases... - Natural resistance to HIV infection: The Vif-APOBEC interactionMichael H Malim
Department of Infectious Diseases, King s College London, School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital, London Bridge, London SE1 9RT, UK
C R Biol 329:871-5. 2006..Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein... - Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variationCraig Pace
Centre for Clinical Immunology and Biomedical Statistics, 2nd Floor, North Block, Royal Perth Hospital, Wellington Street, Perth 6000, Western Australia
J Virol 80:9259-69. 2006..7 log(10) copies/ml; P = 0.001). Defective vif was strongly associated with HIV-1 hypermutation, with additional evidence for a contribution of vif amino acid .. - Changes in the Vif protein of HIV-1 associated with the development of resistance to inhibitors of viral proteaseMelanie A Adekale
Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
J Med Virol 75:195-201. 2005The protease (PR) and virus infectivity factor (vif) gene sequences of a cohort of HIV-1 infected patients showing evidence of developing protease inhibitor (PI) resistance whilst undergoing highly active antiretroviral therapy (HAART) .. - A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteinsHeather L Wiegand
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
EMBO J 23:2451-8. 2004The HIV-1 Vif protein suppresses the inhibition of viral replication caused by the human antiretroviral factor APOBEC3G... - Vif and Apobec3G in the innate immune response to HIV: a tale of two proteinsMelissa A Farrow
College of the Holy Cross, Department of Biology, 1 College Street, Worcester, MA 01610, USA
Future Microbiol 3:145-54. 2008..One such critical virus-host interaction is the recently elucidated interplay between the viral Vif protein and the innate immune defense molecule Apobec3G... - [Enhanced protein production of Vif and APOBEC3G by HIV-1 Vpr]Lin Li
Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 22:39-41. 2008Goal of this study was to test the potential regulatory effects of Vpr on Vif and Vif-mediated degradation of APOBEC3G. - Virus-host interactions: role of HIV proteins Vif, Tat, and RevKlaus Strebel
Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Building-Room 310, 4 Center Drive, MSC 0460, Bethesda, MD 20892-0460, USA
AIDS 17:S25-34. 2003 - The HIV-1 Vif PPLP motif is necessary for human APOBEC3G binding and degradationJohn P Donahue
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, A 2200, Medical Center North, Nashville, TN 37232, USA
Virology 377:49-53. 2008The HIV-1 virion infectivity factor (Vif) is required during viral replication to inactivate the host cell anti-viral factor, APOBEC3G (A3G)... - A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletionHongzhan Xu
HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 101:5652-7. 2004..This innate mechanism of resistance to retroviral infection is counteracted by the HIV-1 viral infectivity factor (Vif), which protects the virus by preventing the incorporation of APOBEC3G into virions by rapidly inducing its .. - HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of actionMariana Santa-Marta
URIA Centro de Patogénese Molecular, Faculdade de Farmacia, Universidade de Lisboa, 1649 019 Lisboa, Portugal
Mol Immunol 44:583-90. 2007HIV-1 Vif protein protects viral replication in non-permissive cells by inducing degradation of APOBEC3G via ubiquitination and proteasomal pathway, although new studies indicate a putative role in Vif's direct inhibition of APOBEC3G... - Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivityJared R Auclair
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Proteins 69:270-84. 2007HIV-1 Vif, an accessory protein in the viral genome, performs an important role in viral pathogenesis by facilitating the degradation of APOBEC3G, an endogenous cellular inhibitor of HIV-1 replication... - Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localizationMichael J Wichroski
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 280:8387-96. 2005To study how HIV-1 viral infectivity factor (Vif) mediates proteasome-dependent depletion of host factor APOBEC3G, functional and nonfunctional Vif-APOBEC3G interactions were correlated with subcellular localization... - Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathwayX Yang
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 73:3460-6. 1999..MAPK has been shown to regulate HIV-1 infectivity by phosphorylating Vif (X. Yang and D. Gabuzda, J. Biol. Chem. 273:29879-29887, 1998)... - The viral infectivity factor (Vif) of HIV-1 unveiledKristine M Rose
Department of Biochemistry and Molecular Biology, Oregon Health and Science University Portland, Oregon 97239 3098, USA
Trends Mol Med 10:291-7. 2004The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic... - Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primatesVeronique Zennou
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, NY 10016, USA
Virology 349:31-40. 2006..Each of four primate lentivirus Vif proteins reduced human and AGM APOBEC3F expression and antiviral activity, but all were only partially effective ..
Research Grants
- Mechanisms involved in HIV-1 Tat mediated neuronal damageFrancesca Peruzzi; Fiscal Year: 2007..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
- Regulation of human microRNA biosynthesis and activityBRYAN CULLEN; Fiscal Year: 2007..Finally, in specific aim 5, we seek to extend our exciting initial data demonstrating inhibition of miRNA function by the adenovirus VA1 non-coding RNA by trying to define the underlying mechanism. ..
- Role and mechanism of action of Gamma herpesvirus microRNAsBRYAN CULLEN; Fiscal Year: 2007..Together, these studies should identify human mRNA targets for several KSHV and EBV miRNAs and shed light on the role of these miRNAs in the replication cycle of Gamma herpesviruses in general. ..
- Peptide Inhibitors of HIV-1 Vif FunctionJohn Donahue; Fiscal Year: 2007..One example of this kind of interaction occurs between the HIV-1 Vif protein and the host cell cytidine deaminase, APOBEC3G...
- Molecular basis of neuronal dysfunction in AIDSFrancesca Peruzzi; Fiscal Year: 2007..The outcome of these studies will provide a new information on the pathways which are affected by HIV-1 Tat, and will assist to improve our effort for developing strategies against HIV-1 induced neuronal cell injury. ..
- Effect of HIV-1 Vpr on Basic Cellular Functions (II)Richard Zhao; Fiscal Year: 2007..abstract_text> ..
- Molecular Mechanism of HIV-1 Vif FunctionBRYAN CULLEN; Fiscal Year: 2007Although expression of the viral Vif protein is critical for HIV-1 replication in primary cells, the mechanism of action of Vif has, until recently, been largely unclear...
- HIV-1: microRNA interactionsBryan R Cullen; Fiscal Year: 2010..This research has the potential to not only shed new light on HIV-1 pathogenesis but also suggest new approaches to inhibit virus replication. ..
- Role and mechanism of action of Gamma herpesvirus microRNAsBryan R Cullen; Fiscal Year: 2010..Together, these studies should identify human mRNA targets for several KSHV and EBV miRNAs and shed light on the role of these miRNAs in the replication cycle of Gamma herpesviruses in general. ..
- Mechanisms involved in HIV-1 Tat mediated neuronal damageFrancesca Peruzzi; Fiscal Year: 2010..We expect that results from this study will critically redefine our knowledge of Tat-mediated neurotoxicity, and can provide potential targets for more effective therapeutic intervention. ..
- Effect of APOBEC3G on retroviruses and retrotransposonsBRYAN CULLEN; Fiscal Year: 2009..and other related APOBEC3 proteins, on HIV-1 replication but also the mechanism of APOBEC3G neutralization by HIV-1 Vif. However, the APOBEC3 protein family must be evolutionarily conserved in humans for reasons unrelated to HIV-1 ..
- Effect of HIV-1 Vpr on Basic Cellular Functions (II)Richard Zhao; Fiscal Year: 2006..abstract_text> ..
- Effect of HIV-1 Vpr on Basic Cellular Functions (II)Richard Zhao; Fiscal Year: 2003..abstract_text> ..
- HIV-1 TROPISM AND CHEMOKINE RECEPTORSBRYAN CULLEN; Fiscal Year: 2002..The final specific aim focusses on the promoter regions of CCR5, the identification of transcription factors that may interact with the promoter, and the use of antisense strategies to block CCR5 expression. ..
- Cell Cycle G2/M Pathway Modulated by Viral Protein RRichard Zhao; Fiscal Year: 2006..These proposed studies will provide a comprehensive framework for this new cell cycle control pathway and provide insights into fundamental aspects of this new G2/M surveillance system of eukaryotic cells. ..