VHR

Summary

Gene Symbol: VHR
Description: dual specificity phosphatase 3
Alias: VHR, dual specificity protein phosphatase 3, dual specificity protein phosphatase VHR, serine/threonine specific protein phosphatase, vaccinia H1-related phosphatase, vaccinia virus phosphatase VH1-related
Species: human
Products:     VHR

Top Publications

  1. Alonso A, Saxena M, Williams S, Mustelin T. Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J Biol Chem. 2001;276:4766-71 pubmed
    The 21-kDa dual specific protein phosphatase VH1-related (VHR) is one of the smallest known phosphatases, and its function has remained obscure...
  2. Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, et al. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003;4:44-8 pubmed
    ..We report here that VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase that inactivates the mitogen-activated kinases Erk2 ..
  3. Arnoldussen Y, Lorenzo P, Pretorius M, Waehre H, Risberg B, Maelandsmo G, et al. The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. Cancer Res. 2008;68:9255-64 pubmed publisher
    ..phosphatases during apoptosis of LNCaP cells and found that Vaccinia H1-related protein (VHR/DUSP3) is up-regulated by androgens during inhibition of apoptosis in LNCaP cells, but not in androgen-independent ..
  4. Wang J, Yeh C, Chou H, Yang C, Fu Y, Chen Y, et al. Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. J Biol Chem. 2011;286:10177-84 pubmed publisher
    Vaccinia H1-related phosphatase (VHR) is classified as a dual specificity phosphatase. Unlike typical dual specificity phosphatases, VHR lacks the MAPK-binding domain and shows poor activity against MAPKs...
  5. Rahmouni S, Cerignoli F, Alonso A, Tsutji T, Henkens R, Zhu C, et al. Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol. 2006;8:524-31 pubmed
    ..Here, we report that the human Vaccinia H1-related (VHR) dual-specific protein tyrosine phosphatase regulates cell-cycle progression and is itself modulated during the ..
  6. Wentworth C, Alam A, Jones R, Nusrat A, Neish A. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3. J Biol Chem. 2011;286:38448-55 pubmed publisher
    ..colonization also led to oxidative inactivation of the redox-sensitive and ERK-specific phosphatase, DUSP3/VHR, and consequent stimulation of ERK pathway signaling...
  7. Ishibashi T, Bottaro D, Chan A, Miki T, Aaronson S. Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A. 1992;89:12170-4 pubmed
    ..were completely abolished by mutagenesis of a single cysteine residue conserved in VH1 and the VH1-related (VHR) human protein...
  8. Yuvaniyama J, Denu J, Dixon J, Saper M. Crystal structure of the dual specificity protein phosphatase VHR. Science. 1996;272:1328-31 pubmed
    ..Here, the crystal structure of a human DSP, vaccinia H1-related phosphatase (or VHR), was determined at 2.1 angstrom resolution...
  9. Hao L, ElShamy W. BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR. Int J Cancer. 2007;121:39-46 pubmed
    ..BRCA1-IRIS overexpression decreases the expression of the dual specificity phosphatase, DUSP3/VHR, an endogenous inhibitor of several MAPKs, including c-Jun N-terminal kinase...

More Information

Publications111 found, 100 shown here

  1. Henkens R, Delvenne P, Arafa M, Moutschen M, Zeddou M, Tautz L, et al. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. BMC Cancer. 2008;8:147 pubmed publisher
    The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle...
  2. Song H, Kim W, Choi J, Kim S, Lee D, Park C, et al. Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation. Sci Rep. 2016;6:28634 pubmed publisher
    ..The binding of vaccinia H1-related (VHR) phosphatase to phosphorylated VRK3 increased its affinity for phospho-ERK and subsequently downregulated ERK ..
  3. Mitsui H, Kiecker F, Shemer A, Cannizzaro M, Wang C, Gulati N, et al. Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria. J Invest Dermatol. 2016;136:2030-2040 pubmed publisher
    ..The molecular and cellular changes in which the epidermal-melanin unit undergoes follicular differentiation as well as upregulation of defined cytokines could drive complex immune, epidermal, and pigmentary alterations. ..
  4. Tautz L, Senis Y, Oury C, Rahmouni S. Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy. Bioorg Med Chem. 2015;23:2786-97 pubmed publisher
    ..We also introduce VHR (DUSP3), a PTP that we recently identified as a major player in platelet biology and thrombosis...
  5. Sweeney T, Braviak L, Tato C, Khatri P. Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis. Lancet Respir Med. 2016;4:213-24 pubmed publisher
    ..National Institute of Allergy and Infectious Diseases, National Library of Medicine, the Stanford Child Health Research Institute, the Society for University Surgeons, and the Bill and Melinda Gates Foundation. ..
  6. Sallustio F, Serino G, Cox S, Dalla Gassa A, Curci C, De Palma G, et al. Aberrantly methylated DNA regions lead to low activation of CD4+ T-cells in IgA nephropathy. Clin Sci (Lond). 2016;130:733-46 pubmed publisher
    ..The present study reveals new molecular mechanisms underlying the abnormal CD4(+) T-cell response in IgAN patients. ..
  7. Franke J, Gebreslasie M, Bauwens I, Deleu J, Siegert F. Earth observation in support of malaria control and epidemiology: MALAREO monitoring approaches. Geospat Health. 2015;10:335 pubmed publisher
    ..High- and very high resolution (HR and VHR) land cover and wetland maps were generated for the identification of potential vector habitats and human ..
  8. Boules M, Strong A, Corcelles R, Haskins I, Ilie R, Wathen C, et al. Single-center ventral hernia repair with porcine dermis collagen implant. Surg Endosc. 2018;32:1820-1827 pubmed publisher
    This study aims to evaluate the outcomes and utilization of porcine acellular dermal collagen implant (PADCI) during VHR at a large tertiary referral center...
  9. Efendiyeva M, Abdurakhmanova A. [PATHOGENETIC ASPECTS OF REHABILITATION OF PATIENTS AFTER CHOLECYSTECTOMY]. Eksp Klin Gastroenterol. 2015;:63-70 pubmed
    ..State of vegetative nervous system passed analysis according to variability of heart rhythm (VHR) by spectral analysis method using "Cardiac technic 4000 AD" cardiac monitor in frame of 24-hr ECG monitoring...
  10. Rahmouni S, Hego A, Delierneux C, Wéra O, Musumeci L, Tautz L, et al. Functional Analysis of Protein Tyrosine Phosphatases in Thrombosis and Hemostasis. Methods Mol Biol. 2016;1447:301-30 pubmed publisher
  11. Russo L, Farias J, Ferruzo P, Monteiro L, Forti F. Revisiting the roles of VHR/DUSP3 phosphatase in human diseases. Clinics (Sao Paulo). 2018;73:e466s pubmed publisher
    ..We also focus on validated substrates and signaling circuitry with clinical relevance in human diseases, particularly oncogenesis. ..
  12. Ecker B, Kuo L, Simmons K, Fischer J, Morris J, Kelz R. Laparoscopic versus open ventral hernia repair: longitudinal outcomes and cost analysis using statewide claims data. Surg Endosc. 2016;30:906-15 pubmed publisher
    ..81, CI 0.75-0.88, p < 0.001) and a lower risk for revisional VHR (OR 0.75, CI 0.64-0.88, p < 0.001)...
  13. Mohan R, Hui Chou H, Wang H, Nam A, Magarakis M, Mundinger G, et al. Physiologic changes with abdominal wall reconstruction in a porcine abdominal compartment syndrome model. Hernia. 2015;19:313-21 pubmed publisher
    ..Ventral hernia repair (VHR) was simulated by abdominal fascial imbrication of a 10 × 15 cm defect in 45 Yorkshire pigs assigned to five ..
  14. Song H, Kim W, Kim S, Kim K. VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and A? accumulation via enhancement of ERK phosphatase VHR activity. Sci Rep. 2016;6:38452 pubmed publisher
    ..Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing ..
  15. Baker E, Lepere D, Lundgren M, Greaney P, Ehrlich D, Copit S, et al. Early Clinical Outcomes of a Novel Antibiotic-Coated, Non-Crosslinked Porcine Acellular Dermal Graft after Complex Abdominal Wall Reconstruction. J Am Coll Surg. 2016;223:581-6 pubmed publisher
    ..Open AWR was performed in 52 patients (70.3%), and 22 patients (29.7%) underwent laparoscopic VHR. Median hernia size/area was 66.0 cm(2) (range 9.4 to 294.5 cm(2)). Sixteen patients (21...
  16. Amand M, Erpicum C, Gilles C, Noël A, Rahmouni S. Functional Analysis of Dual-Specificity Protein Phosphatases in Angiogenesis. Methods Mol Biol. 2016;1447:331-49 pubmed publisher
    ..All methods described can be adapted to other phosphatases and signaling molecules. ..
  17. Mehaffey J, Michaels A, Mullen M, Yount K, Meneveau M, Smith P, et al. Adoption of robotics in a general surgery residency program: at what cost?. J Surg Res. 2017;213:269-273 pubmed publisher
    ..All patients who underwent laparoscopic or robotic cholecystectomy, ventral hernia repair (VHR), and inguinal hernia repair (IHR) at our institution from 2011-2015 were identified...
  18. De Roeck E, Van Coillie F, De Wulf R, Soenen K, Charlier J, Vercruysse J, et al. Fine-scale mapping of vector habitats using very high resolution satellite imagery: a liver fluke case-study. Geospat Health. 2014;8:S671-83 pubmed publisher
    ..hepatica, a parasite liver fluke, as a case in point, this study illustrates the potential of very high resolution (VHR) optical satellite imagery to efficiently and semi-automatically detect detailed vector habitats...
  19. Davila D, Parikh N, Frelich M, Goldblatt M. The increased cost of ventral hernia recurrence: a cost analysis. Hernia. 2016;20:811-817 pubmed publisher
    ..0454). Based on our analysis, need for recurrent VHR adds substantially to total hospital costs and resource utilization...
  20. Guo J, Liu C, Wang W, Liu Y, He H, Chen C, et al. Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer. PLoS ONE. 2018;13:e0200716 pubmed publisher
    ..Collectively, this study provided a new insight that miR-1915-3p might play a role in the development of breast cancer and that serum miR-1915-3p and miR-455-3p could serve as diagnostic and predictive biomarkers for breast cancer. ..
  21. Alsunni A, Majeed F, Yar T, AlRahim A, Alhawaj A, Alzaki M. Effects of energy drink consumption on corrected QT interval and heart rate variability in young obese Saudi male university students. Ann Saudi Med. 2015;35:282-7 pubmed publisher
    ..M%VHR) and the corrected QT interval (QTc) at 0, 30 and 60 minutes after consumption of energy drink...
  22. Zamunér A, Forti M, Andrade C, Avila M, da Silva E. Respiratory Sinus Arrhythmia and its Association with Pain in Women with Fibromyalgia Syndrome. Pain Pract. 2016;16:704-11 pubmed publisher
    ..The RR intervals were recorded in the supine position and during the DBT. The heart rate variability (VHR) was measured by methods in the time and frequency domain...
  23. Craig K, Verma H, Iliyasu Z, Mkanda P, Touray K, Johnson T, et al. Role of Serial Polio Seroprevalence Studies in Guiding Implementation of the Polio Eradication Initiative in Kano, Nigeria: 2011-2014. J Infect Dis. 2016;213 Suppl 3:S124-30 pubmed publisher
    ..in Kano Metropolitan Area, comprising 8 local government areas (LGAs) in Kano that is considered very high risk (VHR) for polio, to monitor performance of the polio eradication program and guide the program in the adoption of ..
  24. Armijo P, Pagkratis S, Boilesen E, Tanner T, Oleynikov D. Growth in robotic-assisted procedures is from conversion of laparoscopic procedures and not from open surgeons' conversion: a study of trends and costs. Surg Endosc. 2018;32:2106-2113 pubmed publisher
    ..4-8.0%), cholecystectomy (0.2-1.8%), IHR (19.9-29.4%), VHR (0.2-2.9%), and bariatric (0.6-5.4%), compared to a decrease in LAP (p < 0.001)...
  25. Hussan H, Ugbarugba E, Bailey M, Porter K, Needleman B, Noria S, et al. The Impact of Bariatric Surgery on Short Term Risk of Clostridium Difficile Admissions. Obes Surg. 2018;28:2006-2013 pubmed publisher
    ..We chose morbidly obese patients that underwent non-emergent ventral hernia repair (VHR) as additional surgical controls (n?=?9673)...
  26. Abdjul D, Yamazaki H, Kanno S, Wewengkang D, Rotinsulu H, Sumilat D, et al. Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp. Bioorg Med Chem Lett. 2017;27:1159-1161 pubmed publisher
    ..T-cell PTP (TCPTP) was approximately 2-fold that against PTP1B, whereas the vaccinia H-1-related phosphatase (VHR) inhibitory effects of 1 were 4-fold weaker than that of its PTP1B inhibitory activity...
  27. Li S, Zhang H, Guo Y, Wu N, Zhu C, Zhao X, et al. Familial hypercholesterolemia in very young myocardial infarction. Sci Rep. 2018;8:8861 pubmed publisher
    ..The FH had similar levels of comorbidities but was younger, more likely to be very high risk (VHR) and had higher GS (p?<?0.05) than unlikely FH...
  28. Warrick K, Althouse S, Rahrig A, Rupenthal J, Batra S. Factors associated with a prolonged hospital stay during induction chemotherapy in newly diagnosed high risk pediatric acute lymphoblastic leukemia. Leuk Res. 2018;71:36-42 pubmed publisher
    High Risk (HR) or Very High Risk (VHR) acute lymphoblastic leukemia (ALL) treated with 4 drug induction chemotherapy is often associated with adverse events...
  29. Ma L, Bayram Y, McLaughlin H, Cho M, Krokosky A, Turner C, et al. De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease. Hum Genet. 2016;135:1399-1409 pubmed
    ..Our data suggest that our heterozygous de novo PPP1CB pathogenic variants are associated with syndromic intellectual disability. ..
  30. Zhao B, Keasey S, Tropea J, Lountos G, Dyas B, Cherry S, et al. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. PLoS ONE. 2015;10:e0134984 pubmed publisher
    ..These newly identified DUSP substrates will be important for examining structure-activity relationships with physiologically relevant targets. ..
  31. Fernandez Moure J, Van Eps J, Menn Z, Cabrera F, Tasciotti E, Weiner B, et al. Platelet rich plasma enhances tissue incorporation of biologic mesh. J Surg Res. 2015;199:412-9 pubmed publisher
    ..because of poor tissue incorporation limit the use of acellular dermal matrices (ADMs) in ventral hernia repair (VHR)...
  32. Qin C, Souza J, Aggarwal A, Kim J. Insulin dependence as an independent predictor of perioperative morbidity after ventral hernia repair: a National Surgical Quality Improvement Program analysis of 45,759 patients. Am J Surg. 2016;211:11-7 pubmed publisher
    ..Although diabetes mellitus has been identified as a predictor of perioperative morbidity after ventral hernia repair (VHR), it is unclear whether insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (..
  33. Totten C, Davenport D, Ward N, Roth J. Cost of ventral hernia repair using biologic or synthetic mesh. J Surg Res. 2016;203:459-65 pubmed publisher
    Patients undergoing ventral hernia repair (VHR) with biologic mesh (BioM) have higher hospital costs compared with synthetic mesh (SynM)...
  34. Sippey M, Mozer A, Grzybowski M, Manwaring M, Kasten K, Adrales G, et al. Obstructing ventral hernias are not independently associated with surgical site infections. J Surg Res. 2015;199:326-30 pubmed publisher
    ..study was to assess the association between bowel obstruction and SSI in patients undergoing ventral hernia repair (VHR). This study is a retrospective database review...
  35. Tian J, Li X, Duan F, Wang J, Ou Y. An Efficient Seam Elimination Method for UAV Images Based on Wallis Dodging and Gaussian Distance Weight Enhancement. Sensors (Basel). 2016;16: pubmed publisher
    ..Aerial Vehicle (UAV) remote sensing conforms to the increasing demand for the low-altitude very high resolution (VHR) image data...
  36. Mo S, Liu X, Hao X, Chen W, Zhang K, Cai J, et al. EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway. Cancer Lett. 2016;380:403-12 pubmed publisher
    ..We showed that EYA4 functioned as tumor suppressor gene in PDAC via repressing ?-catenin/ID2 activation, and was an independent prognostic factor in PDAC. ..
  37. Froylich D, Segal M, Weinstein A, Hatib K, Shiloni E, Hazzan D. Laparoscopic versus open ventral hernia repair in obese patients: a long-term follow-up. Surg Endosc. 2016;30:670-675 pubmed publisher
    ..A retrospective review of patients with a BMI > 30 kg/m(2) that had undergone ventral hernia repair (VHR) between 2004 and 2012 was included...
  38. Wang J, Majumder A, Fayezizadeh M, Criss C, Novitsky Y. Outcomes of Retromuscular Approach for Abdominal Wall Reconstruction in Patients with Inflammatory Bowel Disease. Am Surg. 2016;82:565-70 pubmed
    Ventral hernia repair (VHR) in patients with inflammatory bowel disease (IBD) presents unique surgical challenges including impaired wound healing, concomitant intestinal operations, along with likely future abdominal surgeries...
  39. Saad A, Goldstein J, Lawrence Y, Spieler B, Leibowitz Amit R, Berger R, et al. Classifying high-risk versus very high-risk prostate cancer: is it relevant to outcomes of conformal radiotherapy and androgen deprivation?. Radiat Oncol. 2017;12:5 pubmed publisher
    To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT)...
  40. Schrand K, Hussain L, Dunki Jacobs E, Grannan K. Outcomes associated with resident involvement in ventral hernia repair: A population based study using the NSQIP database. Am J Surg. 2018;216:923-925 pubmed publisher
    This study evaluated the effect of resident involvement on patient outcomes following major ventral hernia repair (VHR)...
  41. Bondre I, Holihan J, Askenasy E, Greenberg J, Keith J, Martindale R, et al. Suture, synthetic, or biologic in contaminated ventral hernia repair. J Surg Res. 2016;200:488-94 pubmed publisher
    ..to support the choice between suture, synthetic mesh, or biologic matrix in contaminated ventral hernia repair (VHR)...
  42. Madani A, Niculiseanu P, Marini W, Kaneva P, Mappin Kasirer B, Vassiliou M, et al. Biologic mesh for repair of ventral hernias in contaminated fields: long-term clinical and patient-reported outcomes. Surg Endosc. 2017;31:861-871 pubmed publisher
    Guidelines recommend biologic prosthetics for ventral hernia repair (VHR) in contaminated fields, yet long-term and patient-reported data are limited...
  43. Makino T, Kaito T, Sakai Y, Takenaka S, Sugamoto K, Yoshikawa H. Plasticity of vertebral wedge deformities in skeletally immature patients with adolescent idiopathic scoliosis after posterior corrective surgery. BMC Musculoskelet Disord. 2016;17:424 pubmed
    ..parts of the vertebral bodies was measured using the original digital viewer, and the vertebral height ratio (VHR: concave/convex) was calculated...
  44. Neupane R, Fayezizadeh M, Majumder A, Novitsky Y. Is old age a contraindication to elective ventral hernia repair?. Surg Endosc. 2017;31:4425-4430 pubmed publisher
    Ventral hernia repair (VHR) is a frequent problem in the expanding aging population. However, advanced age is often viewed as a contraindication to elective hernia surgery...
  45. Haskins I, Horne C, Krpata D, Prabhu A, Tastaldi L, Perez A, et al. A call for standardization of wound events reporting following ventral hernia repair. Hernia. 2018;22:729-736 pubmed publisher
    ..have been made by hernia surgeons to identify and address risk factors for postoperative wound events following VHR, the definition of these events lacks standardization...
  46. Basta M, Fischer J, Wink J, Kovach S. Mortality after inpatient open ventral hernia repair: developing a risk stratification tool based on 55,760 operations. Am J Surg. 2016;211:1047-57 pubmed publisher
    ..No study has stratified patients based on preoperative risk for open ventral hernia repair (VHR) specifically...
  47. Haskins I, Voeller G, Stoikes N, Webb D, Chandler R, Phillips S, et al. Onlay with Adhesive Use Compared with Sublay Mesh Placement in Ventral Hernia Repair: Was Chevrel Right? An Americas Hernia Society Quality Collaborative Analysis. J Am Coll Surg. 2017;224:962-970 pubmed publisher
    The use of mesh during ventral hernia repair (VHR) is a well-accepted concept. However, the ideal location of mesh placement remains strongly debated...
  48. Smolevitz J, Jacobson R, Thaqi M, Millikan S, Millikan K. Outcomes in complex ventral hernia repair with anterior component separation in class III obesity patients. Am J Surg. 2018;215:458-461 pubmed publisher
    Consensus guidelines recommend against elective ventral hernia repair (VHR) in patients with BMI >30 kg/m2 without preoperative weight loss intervention...
  49. Narang A, Gergis C, Robertson S, He P, Ram A, McNutt T, et al. Very High-Risk Localized Prostate Cancer: Outcomes Following Definitive Radiation. Int J Radiat Oncol Biol Phys. 2016;94:254-62 pubmed publisher
    ..of National Comprehensive Cancer Network (NCCN) high-risk prostate cancer patients who are at very high risk (VHR) for poor survival outcomes following prostatectomy were recently developed at our institution and include the ..
  50. Cox T, Huntington C, Blair L, Prasad T, Lincourt A, Heniford B, et al. Predictive modeling for chronic pain after ventral hernia repair. Am J Surg. 2016;212:501-10 pubmed publisher
    ..patients have dissolution of their postoperative discomfort or develop chronic pain after ventral hernia repair (VHR)...
  51. Li C, Balla Arabé S, Ginhac D, Yang F. Embedded Implementation of VHR Satellite Image Segmentation. Sensors (Basel). 2016;16: pubmed publisher
    Processing and analysis of Very High Resolution (VHR) satellite images provide a mass of crucial information, which can be used for urban planning, security issues or environmental monitoring...
  52. Maggioni A, Calabria S, Rossi E, Martini N. Use of lipid lowering drugs in patients at very high risk of cardiovascular events: An analysis on nearly 3,000,000 Italian subjects of the ARNO Observatory. Int J Cardiol. 2017;246:62-67 pubmed publisher
    To assess clinical characteristics, use of resources and costs of patients at very high risk (VHR) of cardiovascular (CV) events. Further, to assess how VHR patients are treated with statins (rate of prescription, dosages, adherence)...
  53. Stearns E, Plymale M, Davenport D, Totten C, Carmichael S, Tancula C, et al. Early outcomes of an enhanced recovery protocol for open repair of ventral hernia. Surg Endosc. 2018;32:2914-2922 pubmed publisher
    ..The purpose of this study was to compare short-term outcomes for open ventral hernia repair (VHR) before and after implementation of an ERAS protocol...
  54. Qin C, Hackett N, Kim J. Assessing the safety of outpatient ventral hernia repair: a NSQIP analysis of 7666 patients. Hernia. 2015;19:919-26 pubmed publisher
    Given the paucity of literature on outpatient ventral hernia repair (VHR), and that assessment of the safety of outpatient surgical procedures is becoming an active area of investigation, we have performed a multi-institutional ..
  55. Basta M, Bauder A, Kovach S, Fischer J. Assessing the predictive accuracy of the American College of Surgeons National Surgical Quality Improvement Project Surgical Risk Calculator in open ventral hernia repair. Am J Surg. 2016;212:272-81 pubmed publisher
    ..of the American College of Surgeons' (ACS) Risk Calculator in patients undergoing open ventral hernia repair (VHR)...
  56. Saleh S, Plymale M, Davenport D, Roth J. Risk-Assessment Score and Patient Optimization as Cost Predictors for Ventral Hernia Repair. J Am Coll Surg. 2018;226:540-546 pubmed publisher
    Ventral hernia repair (VHR) is associated with complications that significantly increase healthcare costs...
  57. Zhou G, Denu J, Wu L, Dixon J. The catalytic role of Cys124 in the dual specificity phosphatase VHR. J Biol Chem. 1994;269:28084-90 pubmed
    The recombinant human Vaccinia virus H1-related protein tyrosine phosphatase, (VHR PTPase) possesses intrinsic Tyr and Thr/Ser phosphatase activities. Both activities were abolished by a single amino acid substitution, C124S...
  58. Todd J, Tanner K, Denu J. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem. 1999;274:13271-80 pubmed
    The mammalian dual-specificity protein-tyrosine phosphatase VHR (for VH1-related) has been identified as a novel regulator of extracellular regulated kinases (ERKs)...
  59. Hamer E, Dijkstra L, Hooijsma S, Zijdewind I, Hadders Algra M. Knee jerk responses in infants at high risk for cerebral palsy: an observational EMG study. Pediatr Res. 2016;80:363-70 pubmed publisher
    ..observation of tonic responses in response to the knee jerk in infants at very high risk for cerebral palsy (VHR infants), we systematically studied tonic responses, clonus, and reflex irradiation...
  60. Francisco N, Fang Y, Ding L, Feng S, Yang Y, Wu M, et al. Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases. J Infect. 2017;75:499-510 pubmed publisher
    ..4% and 85.9%, respectively. Our study reveals that GBP5 and KLF2 may be useful as a diagnostic tool for active TB, also the two-gene set may serve as surrogate biomarkers for monitoring TB therapy. ..
  61. Madabhushi V, Plymale M, Roth J, Johnson S, Wade A, Davenport D. Concomitant open ventral hernia repair: what is the financial impact of performing open ventral hernia with other abdominal procedures concomitantly?. Surg Endosc. 2018;32:1915-1922 pubmed publisher
    Open ventral hernia repair (VHR) is often performed in conjunction with other abdominal procedures...
  62. Jones K, Black D, Brown M, Griffiths B, Nicolai H, Chambers J, et al. The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase. Hum Mol Genet. 1994;3:1927-34 pubmed
    ..the isolation and precise localisation of eight novel genes, including a novel G protein and an endogenous retrovirus related to the HERV-K family, and the previously described dual-specificity VHR phosphatase and MOX1 homeobox genes.
  63. Kim H, Song M, Kwak I, Park T, Lim I. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J Biol Chem. 2003;278:37497-510 pubmed
  64. Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, et al. A module of negative feedback regulators defines growth factor signaling. Nat Genet. 2007;39:503-12 pubmed
    ..More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks. ..
  65. Luechapanichkul R, Chen X, Taha H, Vyas S, Guan X, Freitas M, et al. Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes. J Biol Chem. 2013;288:6498-510 pubmed publisher
    Vaccinia VH1-related (VHR) is a dual specificity phosphatase that consists of only a single catalytic domain...
  66. Haskins I, Krpata D, O Rourke C, Rosenblatt S, Rosen M. The clinical significance of postoperative tachycardia following ventral hernia repair. Surgery. 2016;160:418-25 pubmed publisher
    Early identification of serious adverse events following ventral hernia repair (VHR) could result in improved patient outcomes...
  67. Chipko J, DeSantis A, Quinn E, Velanovich V. Effects of modifiable, non-modifiable and clinical process factors in ventral hernia repair surgical site infections: A retrospective study. Am J Surg. 2017;214:838-843 pubmed publisher
    The hypothesis of this study is that non-modifiable factors are more important in ventral hernia repair (VHR) surgical site infection (SSI) than care process factors...
  68. Chen Y, Chou H, Yang C, Chen H, Liu Y, Lin T, et al. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 2017;36:6509-6517 pubmed publisher
    Vaccinia H1-related phosphatase (VHR/DUSP3) is a member of the dual-specificity phosphatase family. Deregulation of VHR is observed in various malignant diseases. We identified focal adhesion kinase (FAK) as a VHR-interacting molecule...
  69. Kamb A, Futreal P, Rosenthal J, Cochran C, Harshman K, Liu Q, et al. Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. Genomics. 1994;23:163-7 pubmed
    The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer...
  70. Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007;179:3402-6 pubmed
    ..In this article we show that the small dual-specificity phosphatase VHR selectively dephosphorylates IFN-alpha- and beta-activated, tyrosine-phosphorylated STAT5, leading to the ..
  71. Warren J, Stoddard C, Hunter A, Horton A, Atwood C, Ewing J, et al. Effect of Multimodal Analgesia on Opioid Use After Open Ventral Hernia Repair. J Gastrointest Surg. 2017;21:1692-1699 pubmed publisher
    There is limited data on enhanced recovery after surgery (ERAS) protocols after ventral hernia repair (VHR). This study reports the impact of multimodal analgesia on opioid use after open VHR...
  72. Vandereyken M, Jacques S, Van Overmeire E, Amand M, Rocks N, Delierneux C, et al. Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner. PLoS ONE. 2017;12:e0185786 pubmed publisher
    Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers...
  73. Tambe M, Narvi E, Kallio M. Reduced levels of Dusp3/Vhr phosphatase impair normal spindle bipolarity in an Erk1/2 activity-dependent manner. FEBS Lett. 2016;590:2757-67 pubmed publisher
    Dual specificity phosphatase-3 (Dusp3/Vhr) regulates cell cycle progression by counteracting the effects of mitogen-activated protein kinases (Mapk) Erk1/2 and Jnk...
  74. Cui D, Beaumont V, Ginther P, Lipchock J, Loria J. Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases. J Mol Biol. 2017;429:2360-2372 pubmed publisher
    ..protein tyrosine phosphatases (PTP) by creation of single alanine mutations in the catalytic acid loop of PTP1B and VHR. This approach relies on the reciprocal interactions between an allosteric site and its coupled orthosteric site...
  75. Panico K, Forti F. Proteomic, cellular, and network analyses reveal new DUSP3 interactions with nucleolar proteins in HeLa cells. J Proteome Res. 2013;12:5851-66 pubmed publisher
    DUSP3 (or Vaccinia virus phosphatase VH1-related; VHR) is a small dual-specificity phosphatase known to dephosphorylate c-Jun N-terminal kinases and extracellular signal-regulated kinases...
  76. Tomita N, Soga N, Ogura Y, Kageyama T, Kodaira T. Very high-risk prostate cancer: stratification by outcomes of radiotherapy and long-term androgen deprivation therapy. Asia Pac J Clin Oncol. 2017;13:145-151 pubmed publisher
    The definition of very high-risk (VHR) prostate cancer is currently based on the study of radical prostatectomy...
  77. Boxum A, La Bastide Van Gemert S, Dijkstra L, Hamer E, Hielkema T, Reinders Messelink H, et al. Development of the quality of reaching in infants with cerebral palsy: a kinematic study. Dev Med Child Neurol. 2017;59:1164-1173 pubmed publisher
    To assess development of reaching and head stability in infants at very high risk (VHR-infants) of cerebral palsy (CP) who did and did not develop CP...
  78. Amand M, Erpicum C, Bajou K, Cerignoli F, Blacher S, Martin M, et al. DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. Mol Cancer. 2014;13:108 pubmed publisher
    DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases...
  79. Yan Q, Sharma Kuinkel B, Deshmukh H, Tsalik E, Cyr D, Lucas J, et al. Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. PLoS Pathog. 2014;10:e1004149 pubmed publisher
    ..These findings suggest that Dusp3 and Psme3 contribute to S. aureus infection susceptibility in A/J mice and play a role in human S. aureus infection. ..
  80. Näverlo S, Carson D, Edin Liljegren A, Ekstedt M. Patient perceptions of a Virtual Health Room installation in rural Sweden. Rural Remote Health. 2016;16:3823 pubmed
    The Virtual Health Room (VHR) is an ehealth initiative in the village of Slussfors in northern Sweden...
  81. Denu J, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper M, et al. The purification and characterization of a human dual-specific protein tyrosine phosphatase. J Biol Chem. 1995;270:3796-803 pubmed
    ..method was developed to obtain the recombinant human dual-specific protein tyrosine phosphatase (PTPase) VHR in quantities suitable for both kinetic studies and crystallization...
  82. Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
    ..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..
  83. Pavic K, Rios P, Dzeyk K, Koehler C, Lemke E, Köhn M. Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity. ACS Chem Biol. 2014;9:1451-9 pubmed publisher
    Vaccinia H1-related (VHR) phosphatase is a dual specificity phosphatase that is required for cell-cycle progression and plays a role in cell growth of certain cancers. Therefore, it represents a potential drug target...
  84. Singh P, Dejager L, Amand M, Theatre E, Vandereyken M, Zurashvili T, et al. DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock. J Immunol. 2015;194:4951-62 pubmed publisher
    ..Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses by mechanisms involving the control of ERK1/2 activation, TNF secretion, and macrophage polarization. ..
  85. Wong P, AbuBakar S. High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. Cell Mol Biol Lett. 2008;13:375-90 pubmed publisher
    ..6% +/- 6.4%) in the total tyrosine phosphorylated proteins. Vaccinia H1-related (VHR) phosphatase, zeta chain-associated protein-70 (ZAP-70) kinase and phosphorylated extracellular signal-regulated ..
  86. Sharma G, Boules M, Punchai S, Strong A, Froylich D, Zubaidah N, et al. Outcomes of concomitant ventral hernia repair performed during bariatric surgery. Surg Endosc. 2017;31:1573-1582 pubmed publisher
    ..This study aims to evaluate the incidence and outcomes of concomitant ventral hernia repair (VHR) during BS at our institution. Patients who had concomitant VHR during BS from 2004 to 2015 were identified...
  87. Dogan T, Yüksel M, Akça S, Portakal Z, Balci Yegen S, Kucuk N, et al. Normal and anomalous heating rate effects on thermoluminescence of Ce-doped ZnB2O4. Appl Radiat Isot. 2017;128:256-262 pubmed publisher
    ..are examined and, activation energy (E) and frequency factor (s) are determined by using various heating rate (VHR) method...
  88. Cherla D, Moses M, Viso C, Holihan J, Flores Gonzalez J, Kao L, et al. Impact of Abdominal Wall Hernias and Repair on Patient Quality of Life. World J Surg. 2018;42:19-25 pubmed publisher
    ..13-question abdominal wall quality of life (AW-QOL) survey validated in patients undergoing ventral hernia repair (VHR). No studies have assessed AW-QOL among individuals without abdominal wall pathology...
  89. Krpata D, Prabhu A, Carbonell A, Haskins I, Phillips S, Poulose B, et al. Drain Placement Does Not Increase Infectious Complications After Retromuscular Ventral Hernia Repair with Synthetic Mesh: an AHSQC Analysis. J Gastrointest Surg. 2017;21:2083-2089 pubmed publisher
    The use of surgical drains after ventral hernia repair (VHR) remains controversial. Some have concerns of increased infectious complications; others advocate that drains reduce fluid accumulation and surgical site occurrences (SSO)...
  90. Zheng Y, Lv X, Wang J. A genetically encoded sulfotyrosine for VHR function research. Protein Cell. 2013;4:731-4 pubmed publisher
  91. Celio A, Kasten K, Pofahl W, Pories W, Spaniolas K. Causes of readmission after laparoscopic and open ventral hernia repair: Identifying failed discharges and opportunities for action. Surgery. 2016;160:413-7 pubmed publisher
    ..The timing of readmissions after ventral hernia repair (VHR) is poorly defined, and its relationship to laparoscopic or open technique is unclear...
  92. Torres T, Russo L, Santos A, Marques G, Magalhaes Y, Tabassum S, et al. Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways. Biochim Biophys Acta Gen Subj. 2017;1861:1879-1894 pubmed publisher
    ..The radioresistance of tumor cells is effectively reduced by a combination of approaches through the inhibition of DUSPs. ..