Gene Symbol: VEZT
Description: vezatin, adherens junctions transmembrane protein
Alias: VEZATIN, vezatin
Species: human
Products:     VEZT

Top Publications

  1. Hyenne V, Louvet Vallee S, El Amraoui A, Petit C, Maro B, Simmler M. Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. Dev Biol. 2005;287:180-91 pubmed
    ..b>Vezatin is a transmembrane protein of adherens junctions, interacting with the E-cadherin-catenins complex...
  2. Guo X, Jing C, Li L, Zhang L, Shi Y, Wang J, et al. Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c. Biochem Biophys Res Commun. 2011;404:622-7 pubmed publisher
    ..promoter methylation are two vital important mechanisms for transcriptional inactivation of a gene in human cancer; VEZT gene is a plasma membrane component of adherens junctions, the role of VEZT still remains largely unexplored in ..
  3. Kussel Andermann P, El Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, et al. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J. 2000;19:6020-9 pubmed
    ..Here we show that the C-terminal FERM domain of myosin VIIA binds to a novel transmembrane protein, vezatin, which we identified by a yeast two-hybrid screen...
  4. Aparisi M, Aller E, Fuster García C, García García G, Rodrigo R, Vázquez Manrique R, et al. Targeted next generation sequencing for molecular diagnosis of Usher syndrome. Orphanet J Rare Dis. 2014;9:168 pubmed publisher
    ..USH2A, GPR98, DFNB31 and CLRN1), the two Usher syndrome-related genes (HARS and PDZD7) and the two candidate genes VEZT and MYO15A. A cohort of 44 patients suffering from Usher syndrome was selected for this study...
  5. Matalliotakis M, Zervou M, Matalliotaki C, Rahmioglu N, Koumantakis G, Kalogiannidis I, et al. The role of gene polymorphisms in endometriosis. Mol Med Rep. 2017;16:5881-5886 pubmed publisher
    ..investigated whether single nucleotide polymorphisms (SNPs) rs7521902, rs10859871 and rs11031006, mapping to WNT4, VEZT and FSHB genetic loci, respectively, are associated with risk for endometriosis in a Greek population...
  6. Fung J, Mortlock S, Girling J, Holdsworth Carson S, Teh W, Zhu Z, et al. Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Sci Rep. 2018;8:11424 pubmed publisher
    ..Two eQTLs were located in known risk regions for endometriosis including LINC00339 on chromosome 1 and VEZT on chromosome 12 and there was evidence for eQTLs that may be target genes in genomic regions associated with other ..
  7. Osiński M, Mostowska A, Wirstlein P, Wender Ozegowska E, Jagodziński P, Szczepańska M. The assessment of GWAS - identified polymorphisms associated with infertility risk in Polish women with endometriosis. Ginekol Pol. 2018;89:304-310 pubmed publisher
    ..which include rs12700667 near NFE2L3, rs12037376 in WNT4, rs7521902 near WNT4, rs13394619 in GREB1, rs10859871 near VEZT, rs1537377 near CDKN2B-AS1, rs4141819 near ETAA1, rs7739264 near ID4, rs1519761 near RND3 and rs6542095 near IL1A...
  8. Rahmioglu N, Nyholt D, Morris A, Missmer S, Montgomery G, Zondervan K. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update. 2014;20:702-16 pubmed publisher
    ..2 (P = 1.6 × 10(-9)), rs7521902 near WNT4 (P = 1.8 × 10(-15)), rs10859871 near VEZT (P = 4.7 × 10(-15)), rs1537377 near CDKN2B-AS1 (P = 1.5 × 10(-8)), rs7739264 near ID4 (P = 6...
  9. Fung J, Montgomery G. Genetics of endometriosis: State of the art on genetic risk factors for endometriosis. Best Pract Res Clin Obstet Gynaecol. 2018;50:61-71 pubmed publisher
    ..showing altered gene regulation include LINC00339 and CDC42 on chromosome 1, CDKN2A-AS1 on chromosome 9, and VEZT on chromosome 12...

More Information


  1. Holdsworth Carson S, Fung J, Luong H, Sapkota Y, Bowdler L, Wallace L, et al. Endometrial vezatin and its association with endometriosis risk. Hum Reprod. 2016;31:999-1013 pubmed publisher
    Do endometriosis risk-associated single nucleotide polymorphisms (SNPs) found at the 12q22 locus have effects on vezatin ( ITALIC! VEZT) expression? The original genome-wide association study (GWAS) SNP (rs10859871), and other newly ..
  2. Yao X, Arst H, Wang X, Xiang X. Discovery of a vezatin-like protein for dynein-mediated early endosome transport. Mol Biol Cell. 2015;26:3816-27 pubmed publisher
    ..Here our forward genetic study led to the discovery of VezA, a vezatin-like protein in Aspergillus nidulans, as a factor critical for early endosome distribution...
  3. Albertsen H, Chettier R, Farrington P, Ward K. Genome-wide association study link novel loci to endometriosis. PLoS ONE. 2013;8:e58257 pubmed publisher
    ..This GWAS of endometriosis was conducted with high diagnostic certainty in cases, and with stringent handling of population substructure. Our findings broaden the understanding of the genetic factors that play a role in endometriosis. ..
  4. Li Y, Chen Y, Guo X, Liu X, Li L. VEZT as a novel independent prognostic factor in gastric cancer. Cancer Biomark. 2015;15:375-80 pubmed publisher
    b>Vezatin is an transmembrane protein associated with cell-cell adhesion junctions...
  5. Pagliardini L, Gentilini D, Sanchez A, Candiani M, Viganò P, Di Blasio A. Replication and meta-analysis of previous genome-wide association studies confirm vezatin as the locus with the strongest evidence for association with endometriosis. Hum Reprod. 2015;30:987-93 pubmed publisher
    ..identified as associated with endometriosis in an Italian Caucasian population? SNP rs10859871 near the vezatin (VEZT) gene was found to be significantly associated with endometriosis in general while SNPs rs17694933 and ..
  6. Xie D, Shang L, Peng L, Li L. Up-regulation of VEZT by small activating RNA inhibits the proliferation, invasion and migration of gastric cancer cells. Biochem Biophys Res Commun. 2017;482:542-548 pubmed publisher
    To identify an effective saRNA sequence that can specifically up-regulate VEZT expression and to determine the influence of saRNA had on gastric cancer cell growth, proliferation, invasion and migration...
  7. Miao R, Guo X, Zhi Q, Shi Y, Li L, Mao X, et al. VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer. PLoS ONE. 2013;8:e74409 pubmed publisher
    b>Vezatin (VEZT), an adherens junctions transmembrane protein, was identified as a putative tumor suppressor in our previous study. However, the role of VEZT in tumorigenesis remains elusive...
  8. Nyholt D, Low S, Anderson C, Painter J, Uno S, Morris A, et al. Genome-wide association meta-analysis identifies new endometriosis risk loci. Nat Genet. 2012;44:1355-9 pubmed publisher
    ..1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871)...
  9. Blaschuk O, Rowlands T. Plasma membrane components of adherens junctions (Review). Mol Membr Biol. 2002;19:75-80 pubmed
    This review focuses on the three known plasma membrane components of adherens junctions: E-cadherin, nectin-2 and vezatin. The structures of these three components are discussed, with particular emphasis on the molecular mechanisms by ..