VENTX

Summary

Gene Symbol: VENTX
Description: VENT homeobox
Alias: HPX42B, NA88A, VENTX2, VENT homeobox homolog, VENT-like homeobox 2, VENT-like homeobox protein 2, hemopoietic progenitor homeobox protein VENTX2, homeobox protein VENTX
Species: human

Top Publications

  1. pmc VentX trans-activates p53 and p16ink4a to regulate cellular senescence
    Xiaoming Wu
    Gastroenterology Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 286:12693-701. 2011
  2. pmc A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma
    A Moreau-Aubry
    Institut National de la Santé et de la Recherche Médicale INSERM U463, 44093 Nantes Cedex 01, France
    J Exp Med 191:1617-24. 2000
  3. pmc Ventx factors function as Nanog-like guardians of developmental potential in Xenopus
    Pierluigi Scerbo
    Departement Regulations, Developpement et Diversite Moleculaire, Museum national d histoire naturelle, Paris, France
    PLoS ONE 7:e36855. 2012
  4. pmc Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells
    Hong Gao
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 287:29979-87. 2012
  5. pmc Classification and nomenclature of all human homeobox genes
    Peter W H Holland
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    BMC Biol 5:47. 2007
  6. doi VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor
    Hong Gao
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:202-11. 2010
  7. ncbi Functional and hierarchical interactions among zebrafish vox/vent homeobox genes
    Claudio N Gilardelli
    Department of Biology, University of Milan, Milan, Italy
    Dev Dyn 230:494-508. 2004
  8. pmc The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
    Xiaoming Wu
    Department of Medicine, Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2599-613. 2011
  9. ncbi Molecular cloning of a human Vent-like homeobox gene
    P A Moretti
    Human Immunology Division and Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000, Australia
    Genomics 76:21-9. 2001
  10. pmc The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia
    Vijay P S Rawat
    Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm and University Hospital Ulm, 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 107:16946-51. 2010

Scientific Experts

  • Peter W H Holland
  • Xiaoming Wu
  • Hong Gao
  • Zhenglun Zhu
  • Pierluigi Scerbo
  • Weixiong Ke
  • Leslie E Silberstein
  • Roger W Giese
  • Vijay P S Rawat
  • Claudio N Gilardelli
  • Laurent Kodjabachian
  • Shuanhu Zhou
  • Gabriel V Markov
  • Céline Vivien
  • P A Moretti
  • Fabrice Girardot
  • Yan Sun
  • Laurent Coen
  • Barbara Demeneix
  • Guillaume Luxardi
  • Michael R Freeman
  • Sheng Xiao
  • Martin Hager
  • A Moreau-Aubry
  • Bernhard Heilmeier
  • Farid Ahmed
  • Wolfgang Hiddemann
  • Tim Sadlon
  • Natalia Arseni
  • Silvia Thoene
  • Michaela Feuring-Buske
  • Medhanie A Mulaw
  • Yi Le
  • RICHARD J D'ANDREA
  • Christian Buske
  • Stefan K Bohlander
  • Franco Cotelli
  • Giorgio Matassi
  • Ombretta Pozzoli
  • Paolo Sordino
  • A J Davidson
  • L I Zon
  • E Baker
  • R J D'Andrea
  • B Lilley
  • N Labarriere
  • R Breathnach
  • M C Gesnel
  • S Le Guiner
  • F Jotereau

Detail Information

Publications10

  1. pmc VentX trans-activates p53 and p16ink4a to regulate cellular senescence
    Xiaoming Wu
    Gastroenterology Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 286:12693-701. 2011
    ..Using methods of reverse genetics, we recently identified VentX, a human homolog of the vertebrate Xenopus Vent family of homeobox genes, as a novel Wnt repressor and a putative ..
  2. pmc A processed pseudogene codes for a new antigen recognized by a CD8(+) T cell clone on melanoma
    A Moreau-Aubry
    Institut National de la Santé et de la Recherche Médicale INSERM U463, 44093 Nantes Cedex 01, France
    J Exp Med 191:1617-24. 2000
    ..sequence identified it is a processed pseudogene, derived from a retrotranscript of mRNA coding for homeoprotein HPX42B. The NA88-A gene exhibits several premature stop codons, deletions, and insertions relative to the HPX42B gene...
  3. pmc Ventx factors function as Nanog-like guardians of developmental potential in Xenopus
    Pierluigi Scerbo
    Departement Regulations, Developpement et Diversite Moleculaire, Museum national d histoire naturelle, Paris, France
    PLoS ONE 7:e36855. 2012
    ..Joint over-expression of Xenopus ventx1.2 and ventx2.1-b (ventx1/2) counteracts lineage commitment towards both dorsal and ventral fates and prevents msx1-induced ..
  4. pmc Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells
    Hong Gao
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 287:29979-87. 2012
    ..Nevertheless, expansion of human HSC/MPPs for clinical application remains a critical challenge. VentX is a human homeobox transcription factor that was recently identified as an anti-proliferation and pro-..
  5. pmc Classification and nomenclature of all human homeobox genes
    Peter W H Holland
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    BMC Biol 5:47. 2007
    ..Increasingly, homeobox genes are being compared between genomes in an attempt to understand the evolution of animal development. Despite their importance, the full diversity of human homeobox genes has not previously been described...
  6. doi VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor
    Hong Gao
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:202-11. 2010
    ..Here, we report that VentX, a human Xom homologue, is a LEF/TCF-associated inhibitor of canonical Wnt/beta-catenin signaling and a negative ..
  7. ncbi Functional and hierarchical interactions among zebrafish vox/vent homeobox genes
    Claudio N Gilardelli
    Department of Biology, University of Milan, Milan, Italy
    Dev Dyn 230:494-508. 2004
    ..This inhibitory role is emphasized by a vox and vent redundant activity, compared with single gene effects...
  8. pmc The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
    Xiaoming Wu
    Department of Medicine, Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2599-613. 2011
    ..Here we report that the homeobox transcription factor VentX plays a pivotal role in human macrophage terminal differentiation and proinflammatory function...
  9. ncbi Molecular cloning of a human Vent-like homeobox gene
    P A Moretti
    Human Immunology Division and Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000, Australia
    Genomics 76:21-9. 2001
    We have isolated a previously unknown human homeobox-containing cDNA, VENT-like homeobox-2 (VENTX2), using PCR with a bone marrow cDNA library and primers designed from the VENTX1 (alias HPX42) homeobox sequence...
  10. pmc The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia
    Vijay P S Rawat
    Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm and University Hospital Ulm, 89081 Ulm, Germany
    Proc Natl Acad Sci U S A 107:16946-51. 2010
    ..Here we report that the human Vent-like homeobox gene VENTX, a putative homolog of the Xenopus xvent2 gene, is a unique regulatory hematopoietic gene that is aberrantly ..