Gene Symbol: Vegfr-3
Description: fms related tyrosine kinase 4
Alias: FLT-4, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3, vascular endothelial growth factor receptor 3, fms-like tyrosine kinase 4, tyrosine-protein kinase receptor FLT4
Species: human
Products:     Vegfr-3

Top Publications

  1. Lee J, Gray A, Yuan J, Luoh S, Avraham H, Wood W. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. Proc Natl Acad Sci U S A. 1996;93:1988-92 pubmed
    ..A 2.4-kb VRP mRNA is found in several human tissues including adult heart, placenta, ovary, and small intestine and in fetal lung and kidney. ..
  2. Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, et al. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development. 1996;122:3829-37 pubmed
  3. Baldwin M, Catimel B, Nice E, Roufail S, Hall N, Stenvers K, et al. The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. J Biol Chem. 2001;276:19166-71 pubmed
    ..This suggests that VEGF-D and VEGFR-3 may play a role in establishing vessels of the skin by a paracrine mechanism. Our study of receptor specificity suggests that VEGF-D may have different biological functions in mouse and man. ..
  4. Dixelius J, Makinen T, Wirzenius M, Karkkainen M, Wernstedt C, Alitalo K, et al. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem. 2003;278:40973-9 pubmed
  5. Van Trappen P, Steele D, Lowe D, Baithun S, Beasley N, Thiele W, et al. Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J Pathol. 2003;201:544-54 pubmed
    ..VEGFR-3 mRNA expression was found in the cytoplasm of epithelial neoplastic cells and VEGFR3 protein expression was found in more than 50% of CIN 3 lesions and cervical cancers, compared with 15% in CIN 1 ..
  6. Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson Welsh L, Alitalo K. Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. Oncogene. 1994;9:3545-55 pubmed
    ..These results suggest that the endothelial cell FLT4 receptor tyrosine kinase transmits signals for an as yet unidentified growth factor. ..
  7. Achen M, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks A, et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci U S A. 1998;95:548-53 pubmed
    ..In addition, VEGF-D is a mitogen for endothelial cells. The structural and functional similarities between VEGF-D and VEGF-C define a subfamily of the VEGFs. ..
  8. Irrthum A, Karkkainen M, Devriendt K, Alitalo K, Vikkula M. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. Am J Hum Genet. 2000;67:295-301 pubmed
    ..This region contains a good candidate gene for the disease, VEGFR3 (FLT4), that encodes a receptor tyrosine kinase specific for lymphatic vessels...
  9. Makinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice E, et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 2001;20:4762-73 pubmed
    ..The culture of isolated lymphatic endothelial cells should now allow further studies of the molecular properties of these cells. ..

More Information

Publications135 found, 100 shown here

  1. Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature. 2008;454:656-60 pubmed publisher
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors. ..
  2. Eskens F, Steeghs N, Verweij J, Bloem J, Christensen O, van Doorn L, et al. Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors. J Clin Oncol. 2009;27:4169-76 pubmed publisher
    ..9% of patients. Telatinib was safe and well tolerated up to 1,500 mg twice daily. Based on pharmacodynamic and pharmacokinetic end points, telatinib 900 mg twice daily is the recommended dose for subsequent phase II studies. ..
  3. Zeng Y, Opeskin K, Baldwin M, Horvath L, Achen M, Stacker S, et al. Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer. Clin Cancer Res. 2004;10:5137-44 pubmed
    ..Thus the VEGF-C/VEGF-D/VEGF receptor-3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer. ..
  4. Tervala T, Hartiala P, Tammela T, Visuri M, Ylä Herttuala S, Alitalo K, et al. Growth factor therapy and lymph node graft for lymphedema. J Surg Res. 2015;196:200-7 pubmed publisher
    ..VEGF-C, which activates both vascular endothelial growth factor receptor 2 and vascular endothelial growth factor receptor 3, gave the best therapeutic effect in this experimental lymphedema model...
  5. Mishima T, Ito Y, Nishizawa N, Amano H, Tsujikawa K, Miyaji K, et al. RAMP1 signaling improves lymphedema and promotes lymphangiogenesis in mice. J Surg Res. 2017;219:50-60 pubmed publisher
    ..lymphangiogenesis and reduced expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor 3 at the distal edge of the lesions...
  6. Volk Draper L, Hall K, Wilber A, Ran S. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS ONE. 2017;12:e0179257 pubmed publisher
    ..This information can be further exploited for research and therapeutic purposes. ..
  7. Muchowicz A, Wachowska M, Stachura J, Tonecka K, Gabrysiak M, Wołosz D, et al. Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice. Eur J Cancer. 2017;83:19-27 pubmed publisher
    ..inhibition of lymphatic vessels regeneration induced by lenalidomide or the soluble form of vascular endothelial growth factor receptor 3 (sVEGFR3) that neutralises lymphangiogenic vascular endothelial growth factor C (VEGF-C), ..
  8. Cheng M, Li J, Chen Y, Cao D, Gong J, Tu B. VEGF-C attenuates ischemia reperfusion injury of liver graft in rats. Transpl Immunol. 2019;: pubmed publisher
    ..Exogenous VEGF-C protects liver graft from IRI by regulating the inflammatory response and modifying polarization of KCs. ..
  9. Ward M, Cunningham A. Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain. Neuroscience. 2015;303:544-57 pubmed publisher
    ..b>VEGFR3, a mediator of lymphangiogenesis, is expressed in murine and rat brain from early gestation, has been associated ..
  10. Hsu M, Pan M, Hung W. Two Birds, One Stone: Double Hits on Tumor Growth and Lymphangiogenesis by Targeting Vascular Endothelial Growth Factor Receptor 3. Cells. 2019;8: pubmed publisher
    b>Vascular endothelial growth factor receptor 3 (VEGFR3) has been known for its involvement in tumor-associated lymphangiogenesis and lymphatic metastasis...
  11. Ong H, Gokavarapu S, Xu Q, Tian Z, Li J, Ji T, et al. Cytoplasmic neuropilin 2 is associated with metastasis and a poor prognosis in early tongue cancer patients. Int J Oral Maxillofac Surg. 2017;46:1205-1219 pubmed publisher
    ..cell carcinoma (SCC) and overexpression of Nrp2, vascular endothelial growth factor C (VEGFC), vascular endothelial growth factor receptor 3 (VEGFR3), and semaphorin 3F (Sema3F) were analyzed...
  12. Kim Y, Hwang S, Lim J, Kim M, Kim E, Choi B, et al. Attenuated Lymphatic Proliferation Ameliorates Diabetic Nephropathy and High-Fat Diet-Induced Renal Lipotoxicity. Sci Rep. 2019;9:1994 pubmed publisher
  13. Harding J, Ritter A, Rayasam A, Fabry Z, Sandor M. Lymphangiogenesis is induced by mycobacterial granulomas via vascular endothelial growth factor receptor-3 and supports systemic T-cell responses against mycobacterial antigen. Am J Pathol. 2015;185:432-45 pubmed publisher
    ..The observed lymphangiogenesis during infection was reduced by inhibition of vascular endothelial growth factor receptor 3. By using a model of chronic granulomatous infection, we also show that lymphatic remodeling ..
  14. Liu Y, Ren W, Bai Y, Wan L, Sun X, Liu Y, et al. Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis. J Nat Med. 2018;72:481-492 pubmed publisher
    ..Expressions of CD31 and vascular endothelial growth factor receptor-3 (VEGFR3) in tumors were detected by immunohistocehmistry...
  15. Jha S, Rauniyar K, Jeltsch M. Key molecules in lymphatic development, function, and identification. Ann Anat. 2018;219:25-34 pubmed publisher
    ..It is limited in scope to a brief description of their main functions, properties and developmental roles. ..
  16. Lammoglia G, Van Zandt C, Galvan D, Orozco J, Dellinger M, Rutkowski J. Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol. 2016;311:H384-94 pubmed publisher
    ..The inducible TRE-VEGF-D mouse thus provides a novel murine platform to study the adult mechanisms and therapies of an array of disease- and tissue-specific models of lymphangiogenesis. ..
  17. Naruse T, Yanamoto S, Yamada S, Takahashi H, Matsushita Y, Imayama N, et al. Immunohistochemical study of vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis. Oncol Lett. 2015;10:2027-2034 pubmed
    ..Determining the VEGF-C/VEGFR-3 expression status may help predict which patients will develop regional recurrence and provide novel targets for therapies to suppress lymph node metastasis in the treatment of OTSCC. ..
  18. Yu J, Mao L, Guan L, Zhang Y, Zhao J. Ginsenoside Rg1 enhances lymphatic transport of intrapulmonary silica via VEGF-C/VEGFR-3 signaling in silicotic rats. Biochem Biophys Res Commun. 2016;472:182-8 pubmed publisher
  19. Iwami D, Brinkman C, Bromberg J. Vascular endothelial growth factor c/vascular endothelial growth factor receptor 3 signaling regulates chemokine gradients and lymphocyte migration from tissues to lymphatics. Transplantation. 2015;99:668-77 pubmed publisher
    ..Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (VEGFR-3) are the major lymphatic growth factor and receptor...
  20. Zhao J, Hua H, Chen Q, Guan M, Yang J, Xi X, et al. Impact of fenofibrate on choroidal neovascularization formation and VEGF-C plus VEGFR-3 in Brown Norway rats. Exp Eye Res. 2018;174:152-160 pubmed publisher
    ..However, this gradually increased in the early period and declined in the terminal stage in the choroid. VEGF-C and VEGFR-3 participated in the laser-induced CNV formation in BN rats. Fenofibrate could inhibit CNV formation. ..
  21. Alishekevitz D, Gingis Velitski S, Kaidar Person O, Gutter Kapon L, Scherer S, Raviv Z, et al. Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3. Cell Rep. 2016;17:1344-1356 pubmed publisher
    ..Here, we show that vascular endothelial growth factor receptor 3 (VEGFR3)-expressing macrophages infiltrating chemotherapy-treated tumors play a significant ..
  22. Zhao J, Geng Y, Hua H, Cun B, Chen Q, Xi X, et al. Fenofibrate inhibits the expression of VEGFC and VEGFR-3 in retinal pigmental epithelial cells exposed to hypoxia. Exp Ther Med. 2015;10:1404-1412 pubmed
    ..Fenofibrate inhibited the upregulation of VEGFC and VEGFR-3 in the RPE cells exposed to hypoxia, and thus reduced the ability of HUVECs to form new blood vessels. ..
  23. Huang J, Woolf A, Kolatsi Joannou M, Baluk P, Sandford R, Peters D, et al. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. J Am Soc Nephrol. 2016;27:69-77 pubmed publisher
    ..pericystic network of vessels expressing platelet/endothelial cell adhesion molecule 1 and vascular endothelial growth factor receptor 3 (VEGFR3)...
  24. Shi L, Wu Y, Li C. Identification of high-affinity VEGFR3-binding peptides through a phage-displayed random peptide library. J Gynecol Oncol. 2015;26:327-35 pubmed publisher
    ..These finding showed that peptide III has high specificity and activity and, therefore, may represent a potential therapeutic approach to target VEGF-VEGFR-3 signaling for the treatment or diagnosis of ovarian cancer. ..
  25. Li Y, Weng Y, Zhong L, Chong H, Chen S, Sun Y, et al. VEGFR3 inhibition chemosensitizes lung adenocarcinoma A549 cells in the tumor-associated macrophage microenvironment through upregulation of p53 and PTEN. Oncol Rep. 2017;38:2761-2773 pubmed publisher
    ..In the present study we revealed that vascular endothelial growth factor receptor 3 (VEGFR3) inhibition in lung adenocarcinoma cells was associated with improved expression levels of both p53 and PTEN in ..
  26. Han J, Calvo C, Kang T, Baker K, Park J, Parras C, et al. Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans. Cell Rep. 2015;10:1158-72 pubmed publisher
    ..Hippocampal NSC activation and neurogenesis are impaired by conditional deletion of Vegfr3 in NSCs...
  27. Lokmic Z. Utilizing lymphatic cell markers to visualize human lymphatic abnormalities. J Biophotonics. 2017;: pubmed publisher
    ..Allowing for these limitations within new diagnostic visualization technologies is likely to improve our ability to image human lymphatic diseases...
  28. Olmeda D, Cerezo Wallis D, Riveiro Falkenbach E, Pennacchi P, Contreras Alcalde M, Ibarz N, et al. Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Nature. 2017;546:676-680 pubmed publisher
    ..b>Vascular endothelial growth factor receptor 3 (VEGFR3) is an attractive 'lymphoreporter' because its expression is strongly downregulated in ..
  29. Breslin J, Yuan S, Wu M. VEGF-C alters barrier function of cultured lymphatic endothelial cells through a VEGFR-3-dependent mechanism. Lymphat Res Biol. 2007;5:105-13 pubmed
    ..The results indicate differential responses of the lymphatic and vascular endothelial barriers to VEGF-A and VEGF-C. Furthermore, our data suggest that VEGF-C alters lymphatic endothelial function through a mechanism involving VEGFR-3. ..
  30. Yao Q, Cosme J, Xu T, Miszuk J, Picciani P, Fong H, et al. Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation. Biomaterials. 2017;115:115-127 pubmed publisher
    ..The aim of this work was to prepare (via the TISA technique) and evaluate 3D electrospun PCL/PLA blend (mass ratio: 4/1) nanofibrous scaffolds having high porosity of ?95...
  31. Wu T, Wang Y, Song Y, Chen Z, Chen Y, Chiu C, et al. Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development. Sci Rep. 2017;7:1852 pubmed publisher
    ..In conclusion, we demonstrate that cpn1 has a critical role in the vascular development of zebrafish. We also reveal a fine-tune regulation of cpn1 that controls vascular patterning mediated by multiple signals. ..
  32. Gao Y, Li G, Zhou Z, Gao L, Tao Q. Sensitive complex micelles based on host-guest recognition from chitosan-graft-?-cyclodextrin for drug release. Int J Biol Macromol. 2017;105:74-80 pubmed publisher
    ..recognition from chitosan-graft-?-cyclodextrin (CS-g-CD) and benzimidazole-terminated poly(?-caprolactone) (BM-PCL) for controlled drug release...
  33. Smith R, Seamon M, Kumar V, Robinson A, Shults J, Reilly P, et al. Lasting impression of violence: Retained bullets and depressive symptoms. Injury. 2018;49:135-140 pubmed publisher
    ..Interviews, questionnaires and validated survey tools for PTSD (PCL-5) and depression (QIDS-SR16) to assess severity of symptoms were administered 3 months post-injury...
  34. Siafaka P, Üstündağ Okur N, Mone M, Giannakopoulou S, Er S, Pavlidou E, et al. Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes. Int J Mol Sci. 2016;17:282 pubmed publisher
    ..Poly(ε-caprolactone) (PCL) electrospun fibers and β-cyclodextrin (β-CD) complexes, which were produced via an electrospinning process ..
  35. Allen A, Barone E, Crosby C, Suggs L, Zoldan J. Electrospun poly(N-isopropyl acrylamide)/poly(caprolactone) fibers for the generation of anisotropic cell sheets. Biomater Sci. 2017;5:1661-1669 pubmed publisher generate aligned polymer fibers, could be used to fabricate anisotropic PNIPAAm and poly(caprolactone) (PCL) blended surfaces that both support cell viability and permit cell sheet detachment via PNIPAAm dissolution...
  36. Ahn J, Wang J, Kim D, Lee D, Kim J. Does high location and thickness of the Wrisberg ligament affect discoid lateral meniscus tear type based on peripheral detachment?. Knee. 2017;24:1350-1358 pubmed publisher
    ..the presence, location (high or low location), running angle, thickness of WL, and WL/posterior cruciate ligament (PCL) thickness ratio...
  37. Umerska A, Gaucher C, Oyarzun Ampuero F, Fries Raeth I, Colin F, Villamizar Sarmiento M, et al. Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin. Antioxidants (Basel). 2018;7: pubmed publisher
    ..redispersibility after freeze-drying than either poly(lactic-co-glycolic acid) (PLGA) or polycaprolactone (PCL) NPs...
  38. Simiantonaki N, Jayasinghe C, Michel Schmidt R, Peters K, Hermanns M, Kirkpatrick C. Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines. Int J Oncol. 2008;32:585-92 pubmed
    ..Our findings suggest that under hypoxic conditions an autocrine loop between VEGF-C/VEGFR-3 and HIF-1 alpha is possible in breast carcinoma and lung carcinoma but not in colorectal carcinoma cell lines. ..
  39. Noh J, Yoon K, Kyung H, Roh Y, Kang T. Multiple looping technique for tibial fixation in posterior cruciate ligament reconstruction using free tendon Achilles allograft. Knee Surg Sports Traumatol Arthrosc. 2017;25:2640-2645 pubmed publisher
    ..series outcomes of a new tibial fixation technique using a free tendon graft during posterior cruciate ligament (PCL) reconstruction which is less affected by tibial metaphysis bone density...
  40. Peña J, Gutiérrez S, Villamil J, Agudelo N, Pérez L. Policaprolactone/polyvinylpyrrolidone/siloxane hybrid materials: Synthesis and in vitro delivery of diclofenac and biocompatibility with periodontal ligament fibroblasts. Mater Sci Eng C Mater Biol Appl. 2016;58:60-9 pubmed publisher
    In this paper, we report the synthesis of polycaprolactone (PCL) based hybrid materials containing hydrophilic domains composed of N-vinylpyrrolidone (VP), and γ-methacryloxypropyltrimethoxysilane (MPS)...
  41. Silveira N, Longuinho M, Leitão S, Silva R, Lourenço M, Silva P, et al. Synthesis and characterization of the antitubercular phenazine lapazine and development of PLGA and PCL nanoparticles for its entrapment. Mater Sci Eng C Mater Biol Appl. 2016;58:458-66 pubmed publisher
    ..5 ± 1.7 mm, zeta potential of -15.03 mV, and drug loading of 54.71 mg g(-1) for poly-ε-caprolactone (PCL) nanoparticles and a polydispersity index of 0.318,mean diameter of 197.4 ± 2.7 mm, zeta potential of -13...
  42. Ke D, Bose S. Doped tricalcium phosphate bone tissue engineering scaffolds using sucrose as template and microwave sintering: enhancement of mechanical and biological properties. Mater Sci Eng C Mater Biol Appl. 2017;78:398-404 pubmed publisher
    ..74±1.38%. In addition, the incorporation of polycaprolactone (PCL) increased 22.36±3.22% of toughness while maintaining its compressive strength at 25.45±2.21MPa...
  43. Le Kim T, Yu J, Jun H, Yang M, Yang M, Cho J, et al. Polyglycerolated nanocarriers with increased ligand multivalency for enhanced in vivo therapeutic efficacy of paclitaxel. Biomaterials. 2017;145:223-232 pubmed publisher
    ..Linear polyglycerol-poly (?-caprolactone) block copolymer (PG-b-PCL) is used to prepare PGylated lipiodol nanoemulsions, where PG serves as a corona conjugated with a large number of ..
  44. Khandaker M, Riahanizad S. Evaluation of Electrospun Nanofiber-Anchored Silicone for the Degenerative Intervertebral Disc. J Healthc Eng. 2017;2017:5283846 pubmed publisher
    ..Therefore, the PCL ENF mesh anchoring technique to a NP implant can have clinical potential.
  45. Wu Q, Tang X, Liu X, Hou Y, Li H, Yang C, et al. Thermo/pH Dual Responsive Mixed-Shell Polymeric Micelles Based on the Complementary Multiple Hydrogen Bonds for Drug Delivery. Chem Asian J. 2016;11:112-9 pubmed publisher
    ..hydrogen bonding were prepared by self-assembly of diaminotriazine-terminated poly(É›-caprolactone) (DAT-PCL), uracil-terminated methoxy poly(ethylene glycol) (MPEG-U), and uracil-terminated poly(N-vinylcaprolactam) (PNVCL-U)..
  46. Owesen C, Sandven Thrane S, Lind M, Forssblad M, Granan L, Årøen A. Epidemiology of surgically treated posterior cruciate ligament injuries in Scandinavia. Knee Surg Sports Traumatol Arthrosc. 2017;25:2384-2391 pubmed publisher Scandinavia with posterior cruciate ligament reconstruction (PCLR) following a posterior cruciate ligament (PCL) injury...
  47. Kim S, Hwang J, Shin U. Preparation of nano/macroporous polycaprolactone microspheres for an injectable cell delivery system using room temperature ionic liquid and camphene. J Colloid Interface Sci. 2016;465:18-25 pubmed publisher
    The nano/macroporous polycaprolactone (PCL) microspheres with cell active surfaces were developed as an injectable cell delivery system...
  48. Alonso C, Martí M, Barba C, Lis M, Rubio L, Coderch L. Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid. J Photochem Photobiol B. 2016;156:50-5 pubmed publisher, the antioxidant gallic acid (GA) has been encapsulated in microspheres prepared with poly-ε-caprolactone (PCL) and incorporated into polyamide (PA) obtaining the cosmeto-textile...
  49. Shin M, Male I, Beane T, Villefranc J, Kok F, Zhu L, et al. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016;143:3785-3795 pubmed
    ..Moreover, distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations. ..
  50. Bowler R, Adams S, Gocheva V, Li J, Mergler D, Brackbill R, et al. Posttraumatic Stress Disorder, Gender, and Risk Factors: World Trade Center Tower Survivors 10 to 11 Years After the September 11, 2001 Attacks. J Trauma Stress. 2017;: pubmed publisher
    ..and women were compared and factors associated with PTSD symptom severity were examined using the PTSD Checklist (PCL). Compared with men (n = 1,015, 57.8%), women (n = 740, 42.2%) were younger and of lower socioeconomic status...
  51. Mancikova V, Inglada Pérez L, Currás Freixes M, de Cubas A, Gomez A, Leton R, et al. VEGF, VEGFR3, and PDGFRB protein expression is influenced by RAS mutations in medullary thyroid carcinoma. Thyroid. 2014;24:1251-5 pubmed publisher
    ..We assessed by immunohistochemistry the expression of EGFR, KIT, MET, PDGFRB, VEGF, VEGFR1, VEGFR2, and VEGFR3 in a series of 84 primary MTC tumors that had previously been molecularly characterized, including 14 RAS-positive,..
  52. Kulkarni B, Surnar B, Jayakannan M. Dual Functional Nanocarrier for Cellular Imaging and Drug Delivery in Cancer Cells Based on π-Conjugated Core and Biodegradable Polymer Arms. Biomacromolecules. 2016;17:1004-16 pubmed publisher
    ..The present investigation reports a new polymer drug delivery concept based on biodegradable polycaprolactone (PCL) and highly luminescent π-conjugated fluorophore as dual functional nanocarrier for cellular imaging and ..
  53. Fereshteh Z, Fathi M, Bagri A, Boccaccini A. Preparation and characterization of aligned porous PCL/zein scaffolds as drug delivery systems via improved unidirectional freeze-drying method. Mater Sci Eng C Mater Biol Appl. 2016;68:613-622 pubmed publisher
    A novel type of drug-delivery scaffold based on poly(ε-caprolactone) (PCL) and zein blends was prepared by improved unidirectional freeze-drying...
  54. Saeed S, Mirzadeh H, Zandi M, Barzin J. Designing and fabrication of curcumin loaded PCL/PVA multi-layer nanofibrous electrospun structures as active wound dressing. Prog Biomater. 2017;6:39-48 pubmed publisher
    ..electrospinning process is used to fabricate a novel three-layer active wound dressing based on ?-polycaprolactone (PCL), polyvinylalcohol (PVA), and curcumin (CU) as a biologically active compound...
  55. Tegeler C, Cook J, Tegeler C, Hirsch J, Shaltout H, Simpson S, et al. Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress. BMC Psychiatry. 2017;17:141 pubmed publisher
    ..conditions, a subset was identified who reported high scores on the Posttraumatic Stress Disorder Checklist (PCL)...
  56. Röhrich S, Kainberger F, Hirtler L. Evaluation of age-dependent morphometrics of the meniscofemoral ligaments in reference to the posterior cruciate ligament in routine MRI. Eur Radiol. 2018;28:2369-2379 pubmed publisher
    To quantify the morphological correlation between the posterior cruciate ligament (PCL) and the meniscofemoral ligaments (MFLs), to propose normal ranges for different age populations, and to define guidelines for correct identification ..
  57. Van Renterghem J, Dhondt H, Verstraete G, De Bruyne M, Vervaet C, De Beer T. The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets. Int J Pharm. 2018;541:108-116 pubmed publisher
    ..PEO) and the sustained release formulation contained 20-40% (w/w) metoprolol tartrate (MPT) in polycaprolactone (PCL)...
  58. Hou J, Kim S. Possible role of ginsenoside Rb1 in skin wound healing via regulating senescent skin dermal fibroblast. Biochem Biophys Res Commun. 2018;499:381-388 pubmed publisher
    ..endothelial growth factor A (VEGF-A) and D (VEGF-D), vascular endothelial growth factor receptor 2 (VEGFR2) and 3 (VEGFR3)...
  59. Basile M, d Ayala G, Laurienzo P, Malinconico M, Della Ragione F, Oliva A. Development of innovative biopolymers and related composites for bone tissue regeneration: study of their interaction with human osteoprogenitor cells. J Appl Biomater Funct Mater. 2012;10:210-4 pubmed publisher
    In the framework of a project aiming to improve the properties of poly(?-caprolactone) (PCL)-based devices, we prepared novel composites and tested their in vitro biocompatibility and osteogenic capacity on human mesenchymal stromal ..
  60. Ometto M, de Oliveira P, Milioni A, dos Santos B, Scivoletto S, Busatto G, et al. Social skills and psychopathic traits in maltreated adolescents. Eur Child Adolesc Psychiatry. 2016;25:397-405 pubmed publisher
    ..The Hare Psychopathy Checklist: Youth Version (PCL: YV) and a detailed inventory for evaluation of social skills in adolescents were also applied in all individuals...
  61. Jakobsson A, Ottosson M, Zalis M, O Carroll D, Johansson U, Johansson F. Three-dimensional functional human neuronal networks in uncompressed low-density electrospun fiber scaffolds. Nanomedicine. 2017;13:1563-1573 pubmed publisher
    ..system, by the growth of brain neural progenitors in highly porous low density electrospun poly-ε-caprolactone (PCL) fiber scaffolds...
  62. Fang Y, Jiang Y, Zou Y, Meng F, Zhang J, Deng C, et al. Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(ε-caprolactone) micelles. Acta Biomater. 2017;50:396-406 pubmed publisher
    ..reversibly core-crosslinked biodegradable poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-PCL) micelles (cRGD-RCCMs) were designed and developed for highly potent and targeted glioma chemotherapy...
  63. Finotti P, Costa L, Capote T, Scarel Caminaga R, Chinelatto M. Immiscible poly(lactic acid)/poly(ε-caprolactone) for temporary implants: Compatibility and cytotoxicity. J Mech Behav Biomed Mater. 2017;68:155-162 pubmed publisher
    ..CT) on the compatibility and cytotoxicity of immiscible poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) blends...
  64. Tamayol A, Hassani Najafabadi A, Mostafalu P, Yetisen A, Commotto M, Aldhahri M, et al. Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery. Sci Rep. 2017;7:9220 pubmed publisher
    ..Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and ..
  65. Brady J, Sullivan J, Nguyen J, Mintz D, Green D, Strickland S, et al. The Tibial Tubercle-to-Trochlear Groove Distance Is Reliable in the Setting of Trochlear Dysplasia, and Superior to the Tibial Tubercle-to-Posterior Cruciate Ligament Distance When Evaluating Coronal Malalignment in Patellofemoral Instability. Arthroscopy. 2017;33:2026-2034 pubmed publisher
    ..groove (TT-TG) distance measured at the most proximal and distal portions of the trochlea, tibial tubercle-to-PCL (TT-PCL) distance, and Dejour classification of trochlear dysplasia...
  66. George L, Bavya M, Rohan K, Srivastava R. A therapeutic polyelectrolyte-vitamin C nanoparticulate system in polyvinyl alcohol-alginate hydrogel: An approach to treat skin and soft tissue infections caused by Staphylococcus aureus. Colloids Surf B Biointerfaces. 2017;160:315-324 pubmed publisher
    ..polycaprolactone nanoparticles coated with polyelectrolyte-Vitamin C in polyvinyl alcohol-alginate gel (D-PCL-PVc-PVA(Alg)...
  67. Bae J, Yoon J, Sung J, Shin Y. Posterior-stabilized inserts are preferable to cruciate-substituting ultracongruent inserts due to more favourable kinematics and stability. Knee Surg Sports Traumatol Arthrosc. 2018;26:3300-3310 pubmed publisher
    ..Based on the results of the current meta-analysis, in substituting the PCL, PS inserts are preferable to UC inserts due to more favourable kinematics and stability, even though both inserts ..
  68. Lee J, Cho E, Namkung J, Kim E, Kim S, Shin E, et al. Single-nucleotide polymorphisms and haplotypes in the VEGF receptor 3 gene and the haplotype GC in the VEGFA gene are associated with psoriasis in Koreans. J Invest Dermatol. 2008;128:1599-603 pubmed
  69. Alitalo A, Detmar M. Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene. 2012;31:4499-508 pubmed publisher
  70. Deng H, Zhao X, Liu J, Zhang J, Deng L, Liu J, et al. Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release. Nanoscale. 2016;8:1437-50 pubmed publisher
    ..methacrylate) (mPEG-b-(PCL-g-P(DA-co-DMAEMA))) copolymers with two inert pH responsive moieties of DA and DMAEMA...
  71. Evren C, Umut G, Bozkurt M, Evren B, Agachanli R. Mediating role of childhood emotional abuse on the relationship between severity of ADHD and PTSD symptoms in a sample of male inpatients with alcohol use disorder. Psychiatry Res. 2016;239:320-4 pubmed publisher
    ..Trauma Questionnaire (CTQ-28), the Adult ADHD Self-Report Scale (ASRS) and PTSD Checklist Civilian version (PCL-C)...
  72. Beck R, Chaves P, Goyanes A, Vukosavljevic B, Buanz A, Windbergs M, et al. 3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems. Int J Pharm. 2017;528:268-279 pubmed publisher
    ..Drug delivery devices were prepared by fused deposition modelling (FDM) from poly(?-caprolactone) (PCL) and Eudragit® RL100 (ERL) filaments with or without a channelling agent (mannitol)...
  73. Podemska Jedrzejczak Z, Malinska A, Sujka Kordowska P, Nowicki M, Puślecki M, Jemielity M, et al. Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway. Heart Vessels. 2018;33:1106-1120 pubmed publisher
    ..CAV2 protein expression in SMCs of ITA grafts indicated the risk of early graft failure both in double-vessel and triple-vessel CAD subjects. ..
  74. Wang J, Wang J, Lu P, Cai Y, Wang Y, Hong L, et al. Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis. Biomaterials. 2015;62:76-87 pubmed publisher
    ..In vivo study of SCI animal models demonstrated that local delivery of FTY720 with polycaprolactone (PCL) membrane significantly decreased S1P1 expression and glial scarring compared with the control group...
  75. Kuchler Bopp S, Larrea A, Petry L, Idoux Gillet Y, Sebastian V, Ferrandon A, et al. Promoting bioengineered tooth innervation using nanostructured and hybrid scaffolds. Acta Biomater. 2017;50:493-501 pubmed publisher
    ..preparation of CsA loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles, their embedding on polycaprolactone (PCL)-based scaffolds and their possible use as templates for the innervation of bioengineered teeth...
  76. Khalf A, Madihally S. Modeling the permeability of multiaxial electrospun poly(ε-caprolactone)-gelatin hybrid fibers for controlled doxycycline release. Mater Sci Eng C Mater Biol Appl. 2017;76:161-170 pubmed publisher
    ..In this regard, we first explored forming coaxial hybrid fibers from hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic gelatin (GT) in three different configurations, and the release of hydrophilic doxycycline (Dox) ..
  77. Bairey O, Boycov O, Kaganovsky E, Zimra Y, Shaklai M, Rabizadeh E. All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells. Leuk Res. 2004;28:243-8 pubmed
    ..These findings suggest that the VEGF transduction pathway may be very active in CLL cells, and both its paracrine and autocrine pathways may contribute to their enhanced survival. ..
  78. Bianco A, Del Gaudio C, Baiguera S, Armentano I, Bertarelli C, Dottori M, et al. Microstructure and cytocompatibility of electrospun nanocomposites based on poly(epsilon-caprolactone) and carbon nanostructures. Int J Artif Organs. 2010;33:271-82 pubmed
    ..Fibrous composites based on poly(epsilon-caprolactone) (PCL) and CNSs were fabricated by means of electrospinning technique...
  79. Vincent G, Cope L, King J, Nyalakanti P, Kiehl K. Callous-Unemotional Traits Modulate Brain Drug Craving Response in High-Risk Young Offenders. J Abnorm Child Psychol. 2018;46:993-1009 pubmed publisher
    ..Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV). In the stimulant abuser group, drug cues elicited activity in classic reward circuitry...
  80. Begines E, Carrasco C, Montilla F, Álvarez E, Marchetti F, Pettinari R, et al. Oxidoperoxidomolybdenum(vi) complexes with acylpyrazolonate ligands: synthesis, structure and catalytic properties. Dalton Trans. 2017;47:197-208 pubmed publisher
    ..obtained if the reaction was carried out with one equivalent of HQR in the presence of Ph4PCl. Alternatively, neutral complexes [Mo(O)(O2)(QR)2] (R = neopentyl, 9; hexyl, 10; ..
  81. Bertuglia S, Colantuoni A. Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2000;278:H755-61 pubmed
    ..Adherent leukocytes, total perfused capillary length (PCL), permeability increase, and arteriolar and venular red blood cell (RBC) velocity were investigated by fluorescence ..
  82. Petrova T, Bono P, Holnthoner W, Chesnes J, Pytowski B, Sihto H, et al. VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors. Cancer Cell. 2008;13:554-6 pubmed publisher
  83. Qin X, Dai D, Gao Z, Huan J, Zhu L. Effect of lentivirus-mediated shRNA targeting VEGFR-3 on proliferation, apoptosis and invasion of gastric cancer cells. Int J Mol Med. 2011;28:761-8 pubmed publisher
    It has been reported that vascular endothelial growth factor receptor 3 (VEGFR-3) is highly expressed in most tumor tissues, including gastric cancer...
  84. Shi J, Li Y, Yan B, Wei P. Interleukin-8: A potent promoter of human lymphatic endothelial cell growth in gastric cancer. Oncol Rep. 2015;33:2703-10 pubmed publisher
    ..These findings suggest that IL-8 may be a potent inducer of LECs, although this effect does not appear to involve the VEGF-C/VEGF-D and VEGFR-3 signaling pathway. ..
  85. New S, Ibrahim A, Guasti L, Zucchelli E, Birchall M, Bulstrode N, et al. Towards reconstruction of epithelialized cartilages from autologous adipose tissue-derived stem cells. J Tissue Eng Regen Med. 2016;: pubmed publisher
    ..biodegradable nanocomposite polymer, polyhedral oligomeric silsesquioxane poly(?-caprolactone-urea) urethane (POSS-PCL), proliferated and differentiated towards mesenchymal lineages...
  86. Cardoso G, Chacon E, Chacon P, Bordeaux Rego P, Duarte A, Saad S, et al. Fatty acid is a potential agent for bone tissue induction: In vitro and in vivo approach. Exp Biol Med (Maywood). 2017;242:1765-1771 pubmed publisher
    ..Polycaprolactone (PCL) and oleic acid have been studied separately...
  87. Hertel J, Hirche C, Wissmann C, Ebert M, Hocker M. Transcription of the vascular endothelial growth factor receptor-3 (VEGFR3) gene is regulated by the zinc finger proteins Sp1 and Sp3 and is under epigenetic control: transcription of vascular endothelial growth factor receptor 3. Cell Oncol (Dordr). 2014;37:131-45 pubmed publisher
    ..The molecular mechanisms controlling VEGFR3 gene expression have, however, remained poorly understood...
  88. Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, et al. Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury. Lab Invest. 2015;95:1029-43 pubmed publisher
    ..These results indicate that VEGFR-3 is a new target to improve net ultrafiltration by suppressing lymphatic absorption and that the 7.5% icodextrin peritoneal equilibration test is useful for estimation of lymphatic absorption. ..
  89. Al Shareef H, Hiraoka S, Tanaka N, Shogen Y, Lee A, Bakhshishayan S, et al. Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue. Oncol Rep. 2016;36:2444-2454 pubmed publisher
  90. Zhang C, Deng Z, Luo W, Xiao W, Hu Y, Liao Z, et al. Rupture of posterior cruciate ligament leads to radial displacement of the medial meniscus. BMC Musculoskelet Disord. 2017;18:297 pubmed publisher
    To explore the association between the rupture of posterior cruciate ligament (PCL) and the radial displacement of medial meniscus under the conditions of different flexion and various axial loads...
  91. Hwang K, Choi J, Kim J, Chung H, Jin S, Shim J, et al. Comparative Efficacies of Collagen-Based 3D Printed PCL/PLGA/β-TCP Composite Block Bone Grafts and Biphasic Calcium Phosphate Bone Substitute for Bone Regeneration. Materials (Basel). 2017;10: pubmed publisher
    ..After mixing polycaprolactone (PCL), poly (lactic-co-glycolic acid) (PLGA), and β-tricalcium phosphate (β-TCP) in a 4:4:2 ratio, PCL/PLGA/β-TCP ..
  92. Ghosh S, Pradeep V, Muhuri S, Pagonabarraga I, Chaudhuri D. Bidirectional motion of filaments: the role of motor proteins and passive cross linkers. Soft Matter. 2017;13:7129-7140 pubmed publisher
    ..that emerge via a supercritical Hopf bifurcation characterized by an oscillation frequency determined by the MP and PCL parameters...