VE cadherin

Summary

Gene Symbol: VE cadherin
Description: cadherin 5, type 2 (vascular endothelium)
Alias: 7B4, CD144, 7B4 antigen, VE-cadherin, cadherin 5, type 2, VE-cadherin (vascular epithelium), cadherin-5, cd144 antigen, endothelial-specific cadherin, vascular endothelial cadherin
Species: human

Top Publications

  1. doi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
  2. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
  3. ncbi Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state
    Matthew D Potter
    Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:31906-12. 2005
  4. doi Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with Behçet's disease
    Zahra Habibagahi
    Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran
    Mod Rheumatol 20:154-9. 2010
  5. ncbi Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis
    Takeshi Soeki
    Department of Cardiology and Clinical Research, National Zentsuji Hospital, Kagawa, Japan
    Circ J 68:1-5. 2004
  6. ncbi Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site
    Y Wallez
    Laboratoire Développement et Vieillissement de l Endothélium, Département Recherche et Dynamique Cellulaires, Universite Joseph Fourier, Grenoble, INSERM, Grenoble, France
    Oncogene 26:1067-77. 2007
  7. ncbi Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1
    Ronald L Heimark
    Department of Surgery, The University of Arizona, Tucson, AZ, USA
    Curr Eye Res 25:299-308. 2002
  8. doi VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation
    Sabu Abraham
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Curr Biol 19:668-74. 2009
  9. pmc Association of Csk to VE-cadherin and inhibition of cell proliferation
    Ulf Baumeister
    Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    EMBO J 24:1686-95. 2005
  10. pmc VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    Maria Grazia Lampugnani
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Mol Biol Cell 13:1175-89. 2002

Research Grants

  1. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
  2. CRIM1-b-Catenin-Cadherin Interactions in Eye Development and Disease
    RICHARD A contact LANG; Fiscal Year: 2010
  3. Cadherins, integrins, and mechanochemical signaling
    Christopher Chen; Fiscal Year: 2006
  4. FAK in E.coli Pathogenesis
    Lewis Romer; Fiscal Year: 2006
  5. The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration
    William A Muller; Fiscal Year: 2010
  6. Role of CD166/ALCAM in Lung Endothelial Barrier Function
    Solomon Ofori Acquah; Fiscal Year: 2007
  7. Role of CD166/ALCAM in Lung Endothelial Barrier Function
    Solomon Ofori Acquah; Fiscal Year: 2006
  8. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2010
  9. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2006
  10. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2009

Detail Information

Publications185 found, 100 shown here

  1. doi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...
  2. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    b>Vascular endothelial cadherin, VE-cadherin, mediates adhesion between endothelial cells and may affect vascular morphogenesis via intracellular signaling, but the nature of these signals remains unknown...
  3. ncbi Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state
    Matthew D Potter
    Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:31906-12. 2005
    ..These findings demonstrate that a single phosphorylation event within the VE-cadherin cytoplasmic tail is sufficient to maintain cells in a mesenchymal state...
  4. doi Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with Behçet's disease
    Zahra Habibagahi
    Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran
    Mod Rheumatol 20:154-9. 2010
    ..Moreover, endothelial cells express vascular endothelial cadherin adhesion molecule (VE-cadherin), which plays critical roles in angiogenesis and endothelial integrity...
  5. ncbi Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis
    Takeshi Soeki
    Department of Cardiology and Clinical Research, National Zentsuji Hospital, Kagawa, Japan
    Circ J 68:1-5. 2004
    ....
  6. ncbi Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site
    Y Wallez
    Laboratoire Développement et Vieillissement de l Endothélium, Département Recherche et Dynamique Cellulaires, Universite Joseph Fourier, Grenoble, INSERM, Grenoble, France
    Oncogene 26:1067-77. 2007
    ..These data identify that VEGF-induced-VE-cadherin tyrosine phosphorylation is mediated by Src on Y685, a process that appears to be critical for VEGF-induced endothelial cell migration...
  7. ncbi Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1
    Ronald L Heimark
    Department of Surgery, The University of Arizona, Tucson, AZ, USA
    Curr Eye Res 25:299-308. 2002
    ..Conclusions. VE-cadherin and PECAM-1 expression in SC suggests that SC cells are vascular in origin and contain adherens protein likely involved in restricting fluid flow across the inner wall of SC...
  8. doi VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation
    Sabu Abraham
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Curr Biol 19:668-74. 2009
    ..These findings suggest a novel mechanism by which cell-cell adhesion suppresses Rac1-dependent migration and sprouting by increasing actomyosin contractility at cell junctions...
  9. pmc Association of Csk to VE-cadherin and inhibition of cell proliferation
    Ulf Baumeister
    Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    EMBO J 24:1686-95. 2005
    b>Vascular endothelial cadherin (VE-cadherin) mediates contact inhibition of cell growth in quiescent endothelial cell layers...
  10. pmc VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    Maria Grazia Lampugnani
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Mol Biol Cell 13:1175-89. 2002
    ..Through this mechanism VEC may influence the constitutive organization of the actin cytoskeleton...
  11. ncbi A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    Monica Corada
    FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 100:905-11. 2002
    b>Vascular endothelial cadherin (VE-cadherin) is an endothelial-specific, trans-membrane protein that promotes homophilic cell adhesion...
  12. ncbi Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium
    Wen Hong Su
    Department of Physiology and Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Blood 100:3597-603. 2002
    ....
  13. pmc The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis
    Marie Hélène Prandini
    Department of Cellular Responses and Dynamics, CEA INSERM Joseph Fourier University EMI 0219, CEA Grenoble, France
    Oncogene 24:2992-3001. 2005
    ..These results are a first step towards addressing the organ- and tumour-specific regulation of the VE-cadherin gene...
  14. doi Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo
    Wolfgang Moritz Heupel
    University of Wurzburg, Institute of Anatomy and Cell Biology, Koellikerstr 6, D 97070 Wurzburg, Germany
    J Cell Sci 122:1616-25. 2009
    ..Stabilization of VE-cadherin adhesion by cross-bridging peptides may therefore be a novel therapeutic approach for the treatment of vascular hyperpermeability...
  15. doi Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling
    Myriam Labelle
    Institute of Pathology, University of Dresden, Dresden, Germany
    Cancer Res 68:1388-97. 2008
    ..Our findings may have important implications for the clinical application of anti-VE-cadherin strategies...
  16. pmc Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    E Kriehuber
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 194:797-808. 2001
    ..These results demonstrate that LECs and BECs constitute stable and specialized EC lineages equipped with the potential to navigate leukocytes and, perhaps also, tumor cells into and out of the tissues...
  17. ncbi Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading
    Miyuki Sakuma-Zenke
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    J Bone Miner Res 20:1002-10. 2005
    ..This study suggests that the reduced ALP activity after skeletal unloading is related to downregulation of PECAM-1 expression in bone marrow cells in mice...
  18. pmc Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells
    Elena Gorbunova
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 84:7405-11. 2010
    ..paracellular permeability of endothelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (VE-cadherin) within adherens junctions, which is regulated by VEGF receptor-2 (VEGFR2) responses...
  19. ncbi The role of epithelial and vascular-endothelial cadherin in the differentiation and maintenance of tissue integrity
    P Nachtigal
    Charles University, Prague
    Acta Medica (Hradec Kralove) 44:83-7. 2001
    ..Disruption of VE-cadherin-catenin complexes by some inflammatory agents such as thrombin, by inflammatory cells, or shear stress is accompanied by an increase in vascular permeability in vivo and in vitro...
  20. ncbi Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shrevport, LA 71130, USA
    Am J Obstet Gynecol 186:214-20. 2002
    ..We hypothesized that increased endothelial monolayer permeability in preeclampsia reflects altered monolayer barrier properties produced by disorganization of endothelial cell junction proteins...
  21. ncbi Ca2+ signaling, TRP channels, and endothelial permeability
    Chinnaswamy Tiruppathi
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Microcirculation 13:693-708. 2006
    ..These results indicate that endothelial TRP channels such as TRPC1 and TRPC4 play an important role in signaling agonist-induced increases in endothelial permeability...
  22. ncbi Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin
    D Gulino
    Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale Jean Pierre Ebel Commissariat à l Energie Atomique CNRS, 41, avenue des Martyrs, 38027 Grenoble Cedex, France
    J Biol Chem 273:29786-93. 1998
    ..Altogether, these results establish a critical role for VE-cadherin in the maintenance and restoration of endothelium integrity...
  23. ncbi VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function
    Eleni Tzima
    Skaggs Institute for Chemical Biology, Department of Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:2405-8. 2005
    ..Binding of T2-TrpRS inhibited VEGF-induced ERK activation and EC migration. Thus, a VE-cadherin-dependent pathway is proposed to link T2-TrpRS to inhibition of new blood vessel formation...
  24. ncbi Expression of mRNA for cell adhesion molecules in the bovine corpus luteum during the estrous cycle and PGF2alpha-induced luteolysis
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    J Reprod Dev 53:1319-28. 2007
    ..The results suggest that CAMs play physiological roles in cell-to-cell communication to regulate both gap and adherence junctions during CL development and regression in the cow...
  25. ncbi Both protein kinase A and exchange protein activated by cAMP coordinate adhesion of human vascular endothelial cells
    Stuart J Netherton
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Circ Res 101:768-76. 2007
    ..adhesions of vascular endothelial cells (VECs) to extracellular matrix proteins, their vascular endothelial cadherin-dependent intercellular adhesions, and their proliferation and migration in response to growth and ..
  26. doi Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells
    Kumiko Saeki
    Department of Hematology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Cell Physiol 217:261-80. 2008
    ..All adherent cells including sac walls cells and surrounding cobblestone cells expressed vascular endothelial cadherin (VE-cadherin) at intercellular junctions...
  27. ncbi Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells
    P Telo'
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 273:17565-72. 1998
    ..We propose for this new protein the name of vascular endothelial cadherin-2...
  28. pmc TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells
    Virginie Deleuze
    Institut de Génétique Moléculaire de Montpellier CNRS, UMR5535, Montpellier, France
    Mol Cell Biol 27:2687-97. 2007
    ..the inhibition of in vitro tubulomorphogenesis, which was associated with a dramatic reduction in vascular endothelial cadherin (VE-cadherin) at intercellular junctions...
  29. pmc Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation
    Yunhao Liu
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 182:185-96. 2008
    ..Shc activation and its vascular endothelial cadherin (VE-cadherin) association are matrix independent...
  30. ncbi Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells
    Yanqiu Liu
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 18:457-68. 2004
    ....
  31. pmc Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
    A Del Maschio
    Laboratory of Vascular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Cell Biol 135:497-510. 1996
    ..This effect could increase EC permeability and facilitate PMN transmigration during the acute inflammatory reaction...
  32. ncbi Role of Ca2+ signaling in the regulation of endothelial permeability
    Chinnaswamy Tiruppathi
    Department of Pharmacology M C868, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Vascul Pharmacol 39:173-85. 2002
    ..These results indicate that endothelial TRP channels such as TRPC1 and TRPC4 play an important role in signaling the increase in endothelial permeability...
  33. pmc Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Reprod Sci 16:479-88. 2009
    ..Endothelial junction protein vascular endothelial cadherin expression and distribution were examined by fluorescent staining of endothelial cells with or without ..
  34. doi High-efficiency production of subculturable vascular endothelial cells from feeder-free human embryonic stem cells without cell-sorting technique
    Masako Nakahara
    Department of Hematology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Cloning Stem Cells 11:509-22. 2009
    ....
  35. ncbi Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase
    Hélène Hudry-Clergeon
    INSERM EMI 02 19, Laboratoire de Développement et Vieillissement de l Endothélium, Département Réponse Dynamique Cellulaire, Commissariat a l Energie Atomique, Grenoble Cedex 9, France
    FASEB J 19:512-20. 2005
    ..Physical association between PtdIns3'-kinase, serving as a docking protein, and VE-cadherin may thus provide an efficient mechanism for amplification and perpetuation of PAF-induced cellular activation...
  36. ncbi Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability
    Dorota Gabrys
    Department of Radiation Oncology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
    Int J Radiat Oncol Biol Phys 69:1553-62. 2007
    ..To investigate the effects of radiation on the endothelial cytoskeleton and endothelial monolayer permeability and to evaluate associated signaling pathways, which could reveal potential mechanisms of known vascular effects of radiation...
  37. pmc A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    FASEB J 22:3310-7. 2008
    ..The ability of A6 to block retinal vascular permeability in diabetes suggests a potential therapeutic approach for the treatment of diabetic macular edema...
  38. ncbi Serum erythropoietin and angiogenetic factors in human colorectal cancer
    A Chabowska
    Department of Medical, Medical University of Bialystok, Poland
    Prague Med Rep 108:348-57. 2007
    ..Therefore we aimed at measurement and comparison of serum erythropoietin with VEGF, VE-cadherin levels, blood haemoglobin and hematocrit in colorectal cancer patients of different clinicopathological profiles...
  39. ncbi An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds
    Matthias Festag
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Str 65, 88397 Biberach an der Riss, Germany
    Toxicol In Vitro 21:1631-40. 2007
    ....
  40. ncbi Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin
    Katrin Lamszus
    Department of Neurosurgery, Institute for Anatomy II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 11:4934-40. 2005
    ..In addition, we analyzed whether blockade of vascular endothelial (VE)-cadherin as a different antiangiogenic target could also inhibit glioblastoma angiogenesis and growth...
  41. ncbi Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability
    Fang Liao
    ImClone Systems Incorporated, New York, NY 10014, USA
    Cancer Res 62:2567-75. 2002
    ..Our data also suggest that antibody E4G10 recognizes VE-cadherin epitopes that are only accessible on endothelial cells forming new adherens junctions, such as in angiogenic tumor vasculature...
  42. ncbi Architecture of the VE-cadherin hexamer
    Elizabeth A Hewat
    Laboratoire de Microscopie Electronique Structurale, Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, CEA CNRS UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Mol Biol 365:744-51. 2007
    ..In the context of the cell-cell junction these cis-trimers close to the membrane, and trans-dimers from opposing membranes, would increase the avidity of the bond...
  43. pmc Structure of artificial and natural VE-cadherin-based adherens junctions
    Jean Christophe Taveau
    CBMN UMR CNRS 5248 IECB, Universite Bordeaux 1, Avenue des Facultes, 33405 Talence, France
    Biochem Soc Trans 36:189-93. 2008
    In vascular endothelium, adherens junctions between endothelial cells are composed of VE-cadherin (vascular endothelial cadherin), an adhesive receptor that is crucial for the proper assembly of vascular structures and the maintenance of ..
  44. pmc Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras
    Yingxiao Wang
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:1774-9. 2006
    ..The results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network...
  45. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009
    ..However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular development in which this protein is involved...
  46. doi Suppressing PTEN activity by tobacco smoke plus interleukin-1beta modulates dissociation of VE-cadherin/beta-catenin complexes in endothelium
    Silvia S Barbieri
    Department of Pharmacological Sciences, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 28:732-8. 2008
    ....
  47. ncbi Adherens junctions in endothelial cells regulate vessel maintenance and angiogenesis
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Thromb Res 120:S1-6. 2007
    ....
  48. pmc Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin
    Ming Wei Chao
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicology 279:73-84. 2011
    ....
  49. pmc Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin
    Punya Shrivastava-Ranjan
    Special Pathogens Branch, G 14, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Virol 84:11227-34. 2010
    ..These data implicate virus induction of VEGF and reduction in VE-cadherin in the endothelial cell permeability seen in HPS and suggest potential immunotherapeutic targets for the treatment of the disease...
  50. ncbi Distribution of adherens junction mediated by VE-cadherin complex in rat spleen sinus endothelial cells
    Kiyoko Uehara
    Department of Cell Biology, Fukuoka University School of Medicine, Jonan ku, Fukuoka, 814 0180, Japan
    Cell Tissue Res 323:417-24. 2006
    ..These data suggest that adherens junctions, whose formation appears to be mediated by VE-cadherin-catenin complexes, probably regulate the passage of blood cells through the spleen...
  51. ncbi Molecular organization of tight and adherens junctions in the human placental vascular tree
    L Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    Placenta 21:547-57. 2000
    ..b>Vascular endothelial cadherin (VE-cadherin) clusters were co-localized with beta-catenin, an important signal transduction ligand, ..
  52. doi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
    ..In endothelial cells, AJs are largely composed of vascular endothelial cadherin (VE-cadherin), an endothelium-specific member of the cadherin family of adhesion proteins that binds, ..
  53. pmc Kaposi's sarcoma-associated herpesvirus disrupts adherens junctions and increases endothelial permeability by inducing degradation of VE-cadherin
    Li Wu Qian
    Tumor Virology Program, Greehey Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 82:11902-12. 2008
    ..permeability was associated with the disruption of adherens junctions and the degradation of vascular endothelial cadherin (VE-cadherin) protein...
  54. ncbi Putative intermediate precursor between hematogenic endothelial cells and blood cells in the developing embryo
    Stuart T Fraser
    Department of Molecular Genetics, Faculty of Medicine and Graduate School of Medicine, Kyoto University, Shogoin Kawaharacho 53, Sakyo ku, Japan
    Dev Growth Differ 45:63-75. 2003
    ..Collectively, these results introduce a novel VE-cadherin+ population within the developing embryo, which may represent an intermediate cell type in the transition of hemogenic endothelial cells into blood...
  55. ncbi Neutrophils induce sequential focal changes in endothelial adherens junction components: role of elastase
    Carmen V Ionescu
    Vascular Biology Inflammation Program, Lawson Health Research Institute, London, ON, Canada
    Microcirculation 10:205-20. 2003
    ..e., through endothelial cell-cell junctions. Herein, we assessed whether the adherens junctions (AJs) are disrupted during PMN transendothelial cell migration...
  56. ncbi Determination of microvessel density by quantitative real-time PCR in esophageal cancer: correlation with histologic methods, angiogenic growth factor expression, and lymph node metastasis
    Sonja Loges
    Department of Internal Medicine II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 13:76-80. 2007
    ..We compared MVD determination by immunohistology and quantitative real-time PCR and correlated the results with clinical variables...
  57. ncbi The control of endothelial cell functions by adherens junctions
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Novartis Found Symp 283:4-13; discussion 13-7, 238-41. 2007
    ....
  58. doi Confocal immunolocalization of VE-cadherin- and CXC chemokine-expressing endothelial cells in periapical granulomas
    O Takeichi
    Department of Endodontics, Nihon University School of Dentistry, Chiyoda ku, Tokyo, Japan
    Int Endod J 41:401-7. 2008
    ..To determine whether endothelial cells (ECs) in periapical granulomas can express vascular endothelial (VE)-cadherin, CXCL8 and CXCL10 by examining with two-colour confocal laser scanning microscope...
  59. pmc Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells
    Kazuomi Noda
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Mol Biol Cell 21:584-96. 2010
    ....
  60. doi Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice
    Georgios Foteinos
    Department of Cardiac and Vascular Sciences, St George s University of London, London, UK
    Circulation 117:1856-63. 2008
    ..In the present study, we investigated endothelial cell turnover and regeneration in apolipoprotein E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothelial TIE2 promoter...
  61. ncbi VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly
    Christopher V Crosby
    Cardiovascular Developmental Biology Center, Department of Cell Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Blood 105:2771-6. 2005
    ....
  62. pmc Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome
    Junlan Zhang
    Department of Internal Medicine and Liver Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Gastroenterology 136:1070-80. 2009
    ..Pentoxifylline (PTX) directly decreases lung endothelial Akt and eNOS activation, blocks intravascular monocyte accumulation, and improves experimental HPS; we evaluated whether pulmonary angiogenesis develops in this model...
  63. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
    ....
  64. ncbi Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells
    M Ogawa
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Blood 93:1168-77. 1999
    ..5 day postcoitum mouse embryos. Our results suggest that the expression of alpha4-integrin is a marker of the earliest precursor of hematopoietic cell lineage that was diverged from endothelial progenitors...
  65. ncbi Progenitor analysis of primitive erythropoiesis generated from in vitro culture of embryonic stem cells
    Takeshi Otani
    Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Exp Hematol 33:632-40. 2005
    ..In this study, we utilized our coculture system, in which ES-derived Flk-1+ cells differentiated into TER-119+ primitive erythroid (EryP) cells on OP9 cells, and looked for progenitors in primitive erythropoiesis...
  66. pmc Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
    Celeste M Nelson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 15:2943-53. 2004
    ....
  67. doi Preclinical development of tissue-engineered vein valves and venous substitutes using re-endothelialised human vein matrix
    O E Teebken
    Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Eur J Vasc Endovasc Surg 37:92-102. 2009
    ..This technique may enable causal treatment of venous reflux and obstructions...
  68. ncbi Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver
    Samir Taoudi
    MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
    Development 132:4179-91. 2005
    ..5 yolk sac we show that the developmental switch from a ;primary' VE-cadherin+CD45+ to a more ;advanced' VE-cadherin-CD45+ phenotype does not require contact of HSCs with the liver and is probably a function of developmental time...
  69. ncbi Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin
    Kala Venkiteswaran
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 283:C811-21. 2002
    ..These observations suggest that intercellular junction proteins function as components of an adhesion and signaling system that regulates vascular barrier function and growth...
  70. ncbi Homoassociation of VE-cadherin follows a mechanism common to "classical" cadherins
    Thomas Ahrens
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Mol Biol 325:733-42. 2003
    b>Vascular endothelial cadherin (VE-cadherin/cadherin5) is specifically expressed in adherens junctions of endothelial cells and exerts important functions in cell-cell adhesion as well as signal transduction...
  71. ncbi Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor
    Yanping Zhang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    J Soc Gynecol Investig 10:5-10. 2003
    ..Superoxide dismutase partially attenuated the PAF-induced increased endothelial monolayer permeability, which suggests that oxidative stress might be involved in the process of PAF-induced disturbances of endothelial barrier function...
  72. pmc VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers
    Stephen M Akers
    Cancer Cell Biology Program, Robert C Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Exp Hematol 38:733-43. 2010
    ....
  73. pmc Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice
    R H Adamson
    Department of Human Physiology, University of California, Davis, CA 95616, USA
    J Physiol 539:295-308. 2002
    ..Rho proteins as well as RhoA-mediated contractile mechanisms are not involved in bradykinin- or PAF-induced hyperpermeability of intact microvessels...
  74. pmc Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1
    Daniel E Conway
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 23:1024-30. 2013
    ..However, they also argue against the current model of passive transfer of force through the cytoskeleton to the junctions, showing instead that flow triggers cytoskeletal remodeling, which alters forces across the junctional receptors...
  75. doi The role of VE-cadherin in vascular morphogenesis and permeability control
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, University of Milan, Milan, Italy
    Prog Mol Biol Transl Sci 116:119-44. 2013
    ..In addition, the current knowledge about how VE-cadhern participates in the regulation of the endothelial barrier in the adult organism is discussed...
  76. pmc Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels
    S Yang
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California, USA
    Am J Pathol 155:887-95. 1999
    ..Monoclonal antibodies directed against CD31 or vascular endothelial cadherin (VE-cadherin) inhibited the formation of endothelial tubes...
  77. doi Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2
    Nan Zhao
    Department of Pathology, Tianjin Medical University, Heping District Qixiangtai Road No 22, Tianjin, 300070, People s Republic of China
    Med Oncol 29:3599-607. 2012
    ..Therefore, Bcl-2-dependent VE-cadherin overexpression may be an important mechanism by which hypoxia induces VM...
  78. pmc Vascular remodeling alters adhesion protein and cytoskeleton reactions to inflammatory stimuli resulting in enhanced permeability increases in rat venules
    Dong Yuan
    Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    J Appl Physiol (1985) 113:1110-20. 2012
    ..The perivascular cells play important roles in stabilizing the microvessel wall, while lessening an otherwise much greater magnitude of leakage during cytoskeletal contraction...
  79. pmc Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
    Stephan Huveneers
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, 3584 CT, Utrecht, Netherlands
    J Cell Biol 196:641-52. 2012
    ..cell-cell adhesion, inflammatory cytokine- and angiogenic growth factor-induced signals impinge on the vascular endothelial cadherin (VE-cadherin) complex, the central component of endothelial adherens junctions...
  80. pmc PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity
    Emily Vandenbroucke St Amant
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois College of Medicine, 835 S Wolcott Ave, M C 86, Chicago, IL 60612, USA
    Circ Res 111:739-49. 2012
    ..p120 dissociation from VE-cadherin results in loss of VE-cadherin homotypic interaction and AJ disassembly; however, the signaling mechanisms regulating p120 dissociation from VE-cadherin are not understood...
  81. doi Intermedin: a novel regulator for vascular remodeling and tumor vessel normalization by regulating vascular endothelial-cadherin and extracellular signal-regulated kinase
    Wei Zhang
    Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
    Arterioscler Thromb Vasc Biol 32:2721-32. 2012
    ..The aim of this study was to investigate the role of IMD in the angiogenic process and the underlying mechanism, and the possibility for it to be used as a target for angiogenesis-based anticancer therapies...
  82. doi m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis
    Takuro Miyazaki
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Circulation 124:2522-32. 2011
    ..This study focused on the role of calpain, an intracellular cysteine protease, in the proteolytic disorganization of VE-cadherin and subsequent progression of atherosclerosis...
  83. ncbi An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. I: Establishment of the differentiation protocol
    Matthias Festag
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Str 65, 88397 Biberach an der Riss, Germany
    Toxicol In Vitro 21:1619-30. 2007
    ..the expression of platelet-endothelial cell adhesion molecule (PECAM-1), the endothelial-specific vascular endothelial cadherin (VE-Cadherin), the angiopoietin receptor Tie-2, VEGF receptors 1 and 2 (Flt-1 and Flk-1, respectively) ..
  84. doi Derangements in endothelial cell-to-cell junctions involved in the pathogenesis of hypercholesterolemia-induced erectile dysfunction
    Ji Kan Ryu
    Department of Urology and National Research Laboratory of Regenerative Sexual Medicine, Inha University School of Medicine, 7 206 3rd Street, Shinheung Dong, Jung Gu, Incheon, Korea
    J Sex Med 6:1893-907. 2009
    ..Endothelial cell-to-cell junctions are crucial for vascular formation, networking, and remodeling of blood vessels as well as for inducing and integrating intracellular signals...
  85. pmc Hemogenic endothelial progenitor cells isolated from human umbilical cord blood
    Xiao Wu
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Stem Cells 25:2770-6. 2007
    ..Three of 17 clonal cell populations gave rise to early CFU-GEMM hematopoietic progenitors and burst-forming unit-erythroid progenitors. These results provide evidence for hemogenic endothelial cells in human umbilical cord blood...
  86. pmc Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation
    Ana Roussoulières
    INSERM U331 EA 3740, Faculté de médecine RTH Laennec, 8 rue Guillaume Paradin, 69003 Lyon, France
    J Biomed Biotechnol 2007:41705. 2007
    ..01) and to AR grade IA (P = .02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR...
  87. ncbi cDNA cloning, chromosomal mapping, and expression analysis of human VE-Cadherin-2
    D Ludwig
    ImClone Systems Incorporated, New York, New York 10014, USA
    Mamm Genome 11:1030-3. 2000
    Murine vascular endothelial cadherin-2 (VE-cad-2) is a cellular adhesion molecule that is distinct from vascular endothelial cadherin 1 (VE-cad-1) in that it does not interact with catenins and does not appear to affect cell migration or ..
  88. ncbi Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin
    T A Martin
    Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, Wales, UK
    Eur J Clin Invest 31:931-8. 2001
    b>Vascular endothelial cadherin (VE-cadherin/cadherin-5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular ..
  89. pmc Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry
    M J Hendrix
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242 1109, USA
    Proc Natl Acad Sci U S A 98:8018-23. 2001
    ..This finding could pose a significant clinical challenge in targeting tumor cells that may masquerade as circulating endothelial cells or other embryonic-like stem cells...
  90. pmc Peptide Bbeta(15-42) preserves endothelial barrier function in shock
    Marion Groger
    Department of Dermatology, Medical University Vienna, Vienna, Austria
    PLoS ONE 4:e5391. 2009
    ..It stabilizes endothelial barriers and thus could be an attractive adjuvant in the treatment of shock...
  91. doi Glucocorticoids increase VE-cadherin expression and cause cytoskeletal rearrangements in murine brain endothelial cEND cells
    Kinga G Blecharz
    Department of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 28:1139-49. 2008
    ....
  92. pmc Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies
    D Vittet
    Commissariat a l Energie Atomique, Laboratoire d Hematologie, Institut National de la Santé et de la Recherche Médicale U217, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Proc Natl Acad Sci U S A 94:6273-8. 1997
    ..These in vitro experiments are consistent with a pivotal role of VE-cadherin in vascular structure assembly...
  93. pmc p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism
    Christine M Chiasson
    Graduate Program in Biochemistry, Cell, and Developmental Biology, and Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 20:1970-80. 2009
    ....
  94. ncbi Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells
    M G Lampugnani
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Cell Sci 110:2065-77. 1997
    ....
  95. pmc Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization
    P Navarro
    Laboratory of Vascular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Cell Biol 140:1475-84. 1998
    ....
  96. ncbi Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells
    Christine Rampon
    Laboratoire Développement et Vieillissement de l Endothélium CEA Inserm EMI 0219, Grenoble, France
    Exp Cell Res 302:48-60. 2005
    ..We conclude that PCDH12 has a unique expression pattern and that its deficiency does not lead to conspicuous abnormalities. Moreover, PCDH12 is the first specific marker for both glycogen-rich trophoblasts and mesangial cells...
  97. ncbi The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice
    S Gory
    Commissariat a l Energie Atomique CEA, Laboratoire de Transgenèse et Différenciation Cellulaire, Departement de Biologie Moleculaire et Structurale, Grenoble, France
    Blood 93:184-92. 1999
    ....
  98. pmc ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
    Beate Schulz
    Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Circ Res 102:1192-201. 2008
    ....
  99. doi Endothelial cells from cord blood CD133+CD34+ progenitors share phenotypic, functional and gene expression profile similarities with lymphatics
    Van Anh Nguyen
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    J Cell Mol Med 13:522-34. 2009
    ..and macrovascular EC, including CD31, CD36, von Willebrand factor FVIII, CD54 (ICAM-1), CD105 (endoglin), CD144 (VE-cadherin), Tie-1, Tie-2, VEGFR-1/Flt-1 and VEGFR-2/Flk-1...
  100. doi Study of uptake of cell penetrating peptides and their cargoes in permeabilized wheat immature embryos
    Archana Chugh
    Lethbridge Research Centre, Agriculture and Agri Food Canada, Alberta, Canada
    FEBS J 275:2403-14. 2008
    ..This is the first report demonstrating translocation of various cell-penetrating peptides and their potential to deliver macromolecules in wheat immature embryos in the presence of a cell membrane permeabilizing agent...
  101. pmc VE-cadherin is a critical endothelial regulator of TGF-beta signalling
    Noemi Rudini
    Vascular Biology Unit, FIRC Institute of Molecular Oncology, Milan, Italy
    EMBO J 27:993-1004. 2008
    ..This suggests that reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signalling is impaired...

Research Grants92

  1. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  2. CRIM1-b-Catenin-Cadherin Interactions in Eye Development and Disease
    RICHARD A contact LANG; Fiscal Year: 2010
    ..The down-regulation of cadherin expression and activity is also know to be a critical step in epithelial tumor progression as it allows tumor cells to leave the epithelium, become invasive and ultimately form metastases. ..
  3. Cadherins, integrins, and mechanochemical signaling
    Christopher Chen; Fiscal Year: 2006
    ....
  4. FAK in E.coli Pathogenesis
    Lewis Romer; Fiscal Year: 2006
    ..coli K1 disease in the brain microvasculature. Insights into mechanisms of E .coli invasion that are gained here may provide useful paradigms for approaching E. coli disease in other organ systems. ..
  5. The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration
    William A Muller; Fiscal Year: 2010
    ..We will investigate how this compartment functions so that we can design better anti-inflammatory therapies. ..
  6. Role of CD166/ALCAM in Lung Endothelial Barrier Function
    Solomon Ofori Acquah; Fiscal Year: 2007
    ..Blocking vascular endothelial cadherin function causes interstitial pulmonary edema, however normal endothelial cell junctions are formed in ..
  7. Role of CD166/ALCAM in Lung Endothelial Barrier Function
    Solomon Ofori Acquah; Fiscal Year: 2006
    ..Blocking vascular endothelial cadherin function causes interstitial pulmonary edema, however normal endothelial cell junctions are formed in ..
  8. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2010
    ..abstract_text> ..
  9. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2006
    ..The long-term goal is to understand the molecular mechanisms by which ROS regulate EC migration in the context of angiogenesis and endothelial wound repair, which should facilitate the development of new therapeutic strategies. ..
  10. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2009
    ..abstract_text> ..
  11. VEGF Regulation of Microvascular Permeability
    Mack Wu; Fiscal Year: 2007
    ..abstract_text> ..
  12. THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITY
    ASRAR MALIK; Fiscal Year: 2009
    ..By more fully understanding the signaling mechanisms of reversal of increased vascular permeability, we will be better able to develop novel strategies to prevent vascular leakiness and formation of pulmonary edema. ..
  13. THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITY
    Asrar B Malik; Fiscal Year: 2010
    ..By more fully understanding the signaling mechanisms of reversal of increased vascular permeability, we will be better able to develop novel strategies to prevent vascular leakiness and formation of pulmonary edema. ..
  14. THROMBIN INDUCED PULMONARY VASCULAR PERMEABILITY
    ASRAR MALIK; Fiscal Year: 2007
    ....
  15. MODULATION OF THE ENDOTHELIUM BY THROMBIN AND SHEAR
    Marilyn Woolkalis; Fiscal Year: 2004
    ..The proposed research will provide foundation for examining problems of chronic vascular disease where the dysfunctional endothelium no longer appropriately regulates vascular permeability and vessel repair. ..
  16. ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES
    FRANCIS LUSCINSKAS; Fiscal Year: 2003
    ..Specific Aim 3 will utilize in vivo models of chronic inflammation or immune reactions to test the potential role of human JAM in leukocyte recruitment. ..
  17. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2007
    ....
  18. Hemodynamic Adaptation of Intercellular Junctions in Human Endothelium
    Brett R Blackman; Fiscal Year: 2010
    ..Once accomplished, these specific aims will improve understanding of the hemodynamic environment specifically as it relates to heart disease and stroke and lead to new therapeutic targets for this disease. ..
  19. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
    ..The ultimate goal of this project is to provide the foundation for more directed therapies to stimulate the growth of coronary collaterals in patients with IHD. ..
  20. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
    ..The ultimate goal of this project is to provide the foundation for more directed therapies to stimulate the growth of coronary collaterals in patients with IHD. ..
  21. SHEAR STRESS MODULATION OF ENDOTHELIAL WOUND HEALING
    MARIA LUIZA ALBUQUERQUE; Fiscal Year: 2003
    ..Investigation of the mechanisms underlying endothelial repair during shear stress may lead to better strategies for the management of patients suffering from a variety of cardiovascular disorders. ..
  22. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2006
    ..the role of Vascular Endothelial Growth Factor (VEGF) on the inflammatory changes and the reorganization of VE cadherin that occur during ductus remodeling...
  23. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    ..abstract_text> ..
  24. Microvascular Barrier Dysfunction in Thermal Injury
    Sarah Yuan; Fiscal Year: 2009
    ..Information gleaned from this research will significantly advance our understanding of microvascular pathobiology in disease and injury, with the potential to be translated to clinical practice for improved patient care. ..
  25. Microvascular Barrier Dysfunction in Thermal Injury
    Sarah Y Yuan; Fiscal Year: 2010
    ..Information gleaned from this research will significantly advance our understanding of microvascular pathobiology in disease and injury, with the potential to be translated to clinical practice for improved patient care. ..
  26. Hemodynamic Adaptation of Intercelluar Junctions in Human Endothelium
    BRETT BLACKMAN; Fiscal Year: 2009
    ..Once accomplished, these specific aims will improve understanding of the hemodynamic environment specifically as it relates to heart disease and stroke and lead to new therapeutic targets for this disease. ..
  27. Endothelial cell junctions in mechanotransduction
    Eleni Tzima; Fiscal Year: 2009
    ..Project Description Page 6 ..
  28. MECHANISMS OF INFLAMMATORY EDEMA
    DOUGLAS SHASBY; Fiscal Year: 2005
    ..We will use this model to determine if histamine alters cadherin-based adhesion due to effects within the cadherin-catenin complex. ..