VE cadherin

Summary

Gene Symbol: VE cadherin
Description: cadherin 5, type 2 (vascular endothelium)
Alias: 7B4, CD144, 7B4 antigen, VE-cadherin, cadherin 5, type 2, VE-cadherin (vascular epithelium), cadherin-5, cd144 antigen, endothelial-specific cadherin, vascular endothelial cadherin
Species: human

Top Publications

  1. doi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
  2. pmc Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
    Stephan Huveneers
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, 3584 CT, Utrecht, Netherlands
    J Cell Biol 196:641-52. 2012
  3. pmc Integrin α2β1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells
    Mehran Haidari
    Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Biol Chem 287:32981-92. 2012
  4. doi HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells
    Ritu Mishra
    Laboratory of Neurovirology and Inflammation Biology, Council of Scientific and Industrial Research Centre for Cellular and Molecular Biology, Hyderabad 500007, India
    J Neurosci 33:5992-6000. 2013
  5. ncbi Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells
    M G Lampugnani
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Cell Sci 110:2065-77. 1997
  6. pmc ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
    Beate Schulz
    Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Circ Res 102:1192-201. 2008
  7. ncbi A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    Monica Corada
    FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 100:905-11. 2002
  8. pmc Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity
    Yann Fardini
    Department of Periodontics, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Microbiol 82:1468-80. 2011
  9. ncbi Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis
    Takeshi Soeki
    Department of Cardiology and Clinical Research, National Zentsuji Hospital, Kagawa, Japan
    Circ J 68:1-5. 2004
  10. pmc Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue
    S Suzuki
    Department of Ophthalmology, University of Southern California, School of Medicine, Los Angeles 90033
    Cell Regul 2:261-70. 1991

Detail Information

Publications215 found, 100 shown here

  1. doi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...
  2. pmc Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
    Stephan Huveneers
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, 3584 CT, Utrecht, Netherlands
    J Cell Biol 196:641-52. 2012
    ..cell-cell adhesion, inflammatory cytokine- and angiogenic growth factor-induced signals impinge on the vascular endothelial cadherin (VE-cadherin) complex, the central component of endothelial adherens junctions...
  3. pmc Integrin α2β1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells
    Mehran Haidari
    Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Biol Chem 287:32981-92. 2012
    ..Tyrosine phosphorylation of vascular endothelial cadherin (VE-cad) has been implicated in the disruption of endothelial cell adherens junctions and in the ..
  4. doi HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells
    Ritu Mishra
    Laboratory of Neurovirology and Inflammation Biology, Council of Scientific and Industrial Research Centre for Cellular and Molecular Biology, Hyderabad 500007, India
    J Neurosci 33:5992-6000. 2013
    ..These findings demonstrate a novel mechanism for the regulation of barrier permeability by miR-101 via posttranscriptional regulation of VE-cadherin in human BMVECs exposed to the HIV-1 Tat C protein...
  5. ncbi Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells
    M G Lampugnani
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Cell Sci 110:2065-77. 1997
    ....
  6. pmc ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
    Beate Schulz
    Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Circ Res 102:1192-201. 2008
    ....
  7. ncbi A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    Monica Corada
    FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 100:905-11. 2002
    b>Vascular endothelial cadherin (VE-cadherin) is an endothelial-specific, trans-membrane protein that promotes homophilic cell adhesion...
  8. pmc Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity
    Yann Fardini
    Department of Periodontics, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Microbiol 82:1468-80. 2011
    ..nucleatum may serve as an 'enabler' for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens...
  9. ncbi Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis
    Takeshi Soeki
    Department of Cardiology and Clinical Research, National Zentsuji Hospital, Kagawa, Japan
    Circ J 68:1-5. 2004
    ....
  10. pmc Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue
    S Suzuki
    Department of Ophthalmology, University of Southern California, School of Medicine, Los Angeles 90033
    Cell Regul 2:261-70. 1991
    ..These findings show that the cadherin family of adhesion molecules is much larger than previously thought, and suggest that the new cadherins may play an important role in cell-cell interactions within the central nervous system...
  11. doi Breaking the VE-cadherin bonds
    Julie Gavard
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    FEBS Lett 583:1-6. 2009
    ..These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis...
  12. pmc Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells
    Kazuomi Noda
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Mol Biol Cell 21:584-96. 2010
    ....
  13. ncbi Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration
    Bastien Hermant
    Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat à l Energie Atomique CNRS, Universite Joseph Fourier, 41 rue Jules Horowitz, 38027 Grenoble Cedex, France
    J Biol Chem 278:14002-12. 2003
    ..neutrophils across the endothelium occurs at the cell-cell junctions where the vascular endothelium cadherin (VE cadherin) is expressed...
  14. pmc Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein
    Jung Chien Cheng
    From the Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V6H 3V5, Canada
    J Biol Chem 288:33181-92. 2013
    ..human trophoblast cells with TGF-β1 decreased cell invasion and down-regulated the expression of vascular endothelial cadherin (VE-cadherin)...
  15. doi Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling
    Myriam Labelle
    Institute of Pathology, University of Dresden, Dresden, Germany
    Cancer Res 68:1388-97. 2008
    ..Our findings may have important implications for the clinical application of anti-VE-cadherin strategies...
  16. ncbi Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium
    Wen Hong Su
    Department of Physiology and Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Blood 100:3597-603. 2002
    ....
  17. doi Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium
    Weiyong Shen
    Save Sight Institute, The University of Sydney, Australia
    Eur J Cell Biol 90:323-32. 2011
    ..Our results suggest that tyrosine phosphorylation of VE-cadherin and claudin-5 is involved in the increased paracellular permeability of central nervous system-derived vascular endothelium induced by TGF-β1...
  18. pmc High-mobility group box-1 and endothelial cell angiogenic markers in the vitreous from patients with proliferative diabetic retinopathy
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia
    Mediators Inflamm 2012:697489. 2012
    ..4; 95% confidence interval = 6.32-923) and high levels of sEng (odds ratio = 6.01; 95% confidence interval = 1.25-29.0). Our findings suggest that HMGB1, VEGF, sVE-cadherin and sEng regulate the angiogenesis in PDR...
  19. ncbi Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1
    Ronald L Heimark
    Department of Surgery, The University of Arizona, Tucson, AZ, USA
    Curr Eye Res 25:299-308. 2002
    ..Conclusions. VE-cadherin and PECAM-1 expression in SC suggests that SC cells are vascular in origin and contain adherens protein likely involved in restricting fluid flow across the inner wall of SC...
  20. ncbi VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892 4340, USA
    Nat Cell Biol 8:1223-34. 2006
    ....
  21. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
    ..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
  22. pmc VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    Maria Grazia Lampugnani
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Mol Biol Cell 13:1175-89. 2002
    ..Through this mechanism VEC may influence the constitutive organization of the actin cytoskeleton...
  23. doi CCM1 regulates vascular-lumen organization by inducing endothelial polarity
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    J Cell Sci 123:1073-80. 2010
    ..We propose that VEC, CCM1 and Rap1 form a signaling complex. In the absence of any of these proteins, AJs are dismantled, cell polarity is lost and vascular lumenal structure is severely altered...
  24. pmc VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts
    Roman Nawroth
    Max Planck Institute for Vascular Biology, D 48149 Munster, Germany
    EMBO J 21:4885-95. 2002
    ..Thus, VE-PTP is a transmembrane binding partner of VE-cadherin that associates through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin and cell layer permeability independently of its enzymatic activity...
  25. pmc A novel endothelial-specific membrane protein is a marker of cell-cell contacts
    M G Lampugnani
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Cell Biol 118:1511-22. 1992
    ..On the basis of its distribution in cultured cells and in tissues in situ, 7B4 antigen is distinct from other described EC proteins enriched at intercellular contacts...
  26. ncbi Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    Matthijs R H Kooistra
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
    FEBS Lett 579:4966-72. 2005
    ..From these results we conclude that in human umbilical vein endothelial cells Epac1 controls VE-cadherin-mediated cell junction formation and induces reorganization of the actin cytoskeleton...
  27. ncbi Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state
    Matthew D Potter
    Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:31906-12. 2005
    ..These findings demonstrate that a single phosphorylation event within the VE-cadherin cytoplasmic tail is sufficient to maintain cells in a mesenchymal state...
  28. pmc A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells
    Sandra Iden
    Institute of Medical Biochemistry, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    EMBO Rep 7:1239-46. 2006
    ..Both PAR-3 and PAR-6 associate directly with the adherens junction protein vascular endothelial cadherin (VE-cadherin). This association is direct and mediated through non-overlapping domains in VE-cadherin...
  29. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    b>Vascular endothelial cadherin, VE-cadherin, mediates adhesion between endothelial cells and may affect vascular morphogenesis via intracellular signaling, but the nature of these signals remains unknown...
  30. pmc Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
    Shigetomo Fukuhara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Mol Cell Biol 25:136-46. 2005
    ..In conclusion, cAMP-Epac-Rap1 signaling promotes decreased cell permeability by enhancing VE-cadherin-mediated adhesion lined by the rearranged cortical actin...
  31. ncbi SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin
    J A Ukropec
    Department of Physiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799, USA
    J Biol Chem 275:5983-6. 2000
    ..Such changes in adherens junction complex composition likely underlie thrombin-elicited alterations in endothelial monolayer permeability...
  32. ncbi Basal-to-apical cadherin flow at cell junctions
    Yoshiko Kametani
    Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 9:92-8. 2007
    ..We propose that cadherin flow may provide a mechanism for facilitating the sliding of the two contacting cell membranes in morphogenetically active cell sheets...
  33. pmc Association of Csk to VE-cadherin and inhibition of cell proliferation
    Ulf Baumeister
    Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    EMBO J 24:1686-95. 2005
    b>Vascular endothelial cadherin (VE-cadherin) mediates contact inhibition of cell growth in quiescent endothelial cell layers...
  34. doi VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation
    Sabu Abraham
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Curr Biol 19:668-74. 2009
    ..These findings suggest a novel mechanism by which cell-cell adhesion suppresses Rac1-dependent migration and sprouting by increasing actomyosin contractility at cell junctions...
  35. pmc The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis
    Marie Hélène Prandini
    Department of Cellular Responses and Dynamics, CEA INSERM Joseph Fourier University EMI 0219, CEA Grenoble, France
    Oncogene 24:2992-3001. 2005
    ..These results are a first step towards addressing the organ- and tumour-specific regulation of the VE-cadherin gene...
  36. ncbi Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site
    Y Wallez
    Laboratoire Développement et Vieillissement de l Endothélium, Département Recherche et Dynamique Cellulaires, Universite Joseph Fourier, Grenoble, INSERM, Grenoble, France
    Oncogene 26:1067-77. 2007
    ..These data identify that VEGF-induced-VE-cadherin tyrosine phosphorylation is mediated by Src on Y685, a process that appears to be critical for VEGF-induced endothelial cell migration...
  37. doi Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo
    Wolfgang Moritz Heupel
    University of Wurzburg, Institute of Anatomy and Cell Biology, Koellikerstr 6, D 97070 Wurzburg, Germany
    J Cell Sci 122:1616-25. 2009
    ..Stabilization of VE-cadherin adhesion by cross-bridging peptides may therefore be a novel therapeutic approach for the treatment of vascular hyperpermeability...
  38. ncbi Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin
    D Michael Shasby
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1330-8. 2002
    ..Within 60 s, histamine simulated a doubling in the phosphorylation of VE-cadherin and beta- and gamma-catenin. The VE-cadherin immunoprecipitate contained kinase activity that phosphorylated VE-cadherin and gamma-catenin in vitro...
  39. pmc VE-cadherin and PECAM-1 enhance ALL migration across brain microvascular endothelial cell monolayers
    Stephen M Akers
    Cancer Cell Biology Program, Robert C Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Exp Hematol 38:733-43. 2010
    ....
  40. doi Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with Behçet's disease
    Zahra Habibagahi
    Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran
    Mod Rheumatol 20:154-9. 2010
    ..Moreover, endothelial cells express vascular endothelial cadherin adhesion molecule (VE-cadherin), which plays critical roles in angiogenesis and endothelial integrity...
  41. pmc Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway
    Soo Hyeon Kim
    Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, Korea
    Blood 120:4892-902. 2012
    ..barrier function, TIMP-2 elevates cytosolic levels of cAMP and increases cytoskeletal-associated vascular endothelial cadherin in human microvascular endothelial cells...
  42. doi Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation
    Sophie Pirotte
    Metastasis Research Laboratory, Grappe Disciplinaire de Génoprotéomique Appliquée GIGA Cancer, Liege, Belgium
    Blood 117:2515-26. 2011
    ..We demonstrate that this extracellular matrix protein induced the expression of vascular endothelial cadherin (VE-cadherin), a key regulator of intercellular junctions and contact inhibition of growth of ..
  43. doi Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions
    Ken Hashimoto
    First Department of Physiology, Kawasaki Medical School, Kurashiki, Japan
    Int J Cardiol 149:232-9. 2011
    ..In this study, we tested the hypothesis that monocyte transmigration alters endothelial junctional organization to facilitate subsequent transmigration...
  44. pmc Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    E Kriehuber
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 194:797-808. 2001
    ..These results demonstrate that LECs and BECs constitute stable and specialized EC lineages equipped with the potential to navigate leukocytes and, perhaps also, tumor cells into and out of the tissues...
  45. ncbi Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading
    Miyuki Sakuma-Zenke
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    J Bone Miner Res 20:1002-10. 2005
    ..This study suggests that the reduced ALP activity after skeletal unloading is related to downregulation of PECAM-1 expression in bone marrow cells in mice...
  46. pmc Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells
    Elena Gorbunova
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 84:7405-11. 2010
    ..paracellular permeability of endothelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (VE-cadherin) within adherens junctions, which is regulated by VEGF receptor-2 (VEGFR2) responses...
  47. ncbi The role of epithelial and vascular-endothelial cadherin in the differentiation and maintenance of tissue integrity
    P Nachtigal
    Charles University, Prague
    Acta Medica (Hradec Kralove) 44:83-7. 2001
    ..Disruption of VE-cadherin-catenin complexes by some inflammatory agents such as thrombin, by inflammatory cells, or shear stress is accompanied by an increase in vascular permeability in vivo and in vitro...
  48. ncbi Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shrevport, LA 71130, USA
    Am J Obstet Gynecol 186:214-20. 2002
    ..We hypothesized that increased endothelial monolayer permeability in preeclampsia reflects altered monolayer barrier properties produced by disorganization of endothelial cell junction proteins...
  49. ncbi Ca2+ signaling, TRP channels, and endothelial permeability
    Chinnaswamy Tiruppathi
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Microcirculation 13:693-708. 2006
    ..These results indicate that endothelial TRP channels such as TRPC1 and TRPC4 play an important role in signaling agonist-induced increases in endothelial permeability...
  50. ncbi Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin
    D Gulino
    Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale Jean Pierre Ebel Commissariat à l Energie Atomique CNRS, 41, avenue des Martyrs, 38027 Grenoble Cedex, France
    J Biol Chem 273:29786-93. 1998
    ..Altogether, these results establish a critical role for VE-cadherin in the maintenance and restoration of endothelium integrity...
  51. ncbi VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function
    Eleni Tzima
    Skaggs Institute for Chemical Biology, Department of Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:2405-8. 2005
    ..Binding of T2-TrpRS inhibited VEGF-induced ERK activation and EC migration. Thus, a VE-cadherin-dependent pathway is proposed to link T2-TrpRS to inhibition of new blood vessel formation...
  52. ncbi Both protein kinase A and exchange protein activated by cAMP coordinate adhesion of human vascular endothelial cells
    Stuart J Netherton
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Circ Res 101:768-76. 2007
    ..adhesions of vascular endothelial cells (VECs) to extracellular matrix proteins, their vascular endothelial cadherin-dependent intercellular adhesions, and their proliferation and migration in response to growth and ..
  53. ncbi Expression of mRNA for cell adhesion molecules in the bovine corpus luteum during the estrous cycle and PGF2alpha-induced luteolysis
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    J Reprod Dev 53:1319-28. 2007
    ..The results suggest that CAMs play physiological roles in cell-to-cell communication to regulate both gap and adherence junctions during CL development and regression in the cow...
  54. doi Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells
    Kumiko Saeki
    Department of Hematology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Cell Physiol 217:261-80. 2008
    ..All adherent cells including sac walls cells and surrounding cobblestone cells expressed vascular endothelial cadherin (VE-cadherin) at intercellular junctions...
  55. ncbi Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells
    P Telo'
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 273:17565-72. 1998
    ..We propose for this new protein the name of vascular endothelial cadherin-2...
  56. pmc TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells
    Virginie Deleuze
    Institut de Génétique Moléculaire de Montpellier CNRS, UMR5535, Montpellier, France
    Mol Cell Biol 27:2687-97. 2007
    ..the inhibition of in vitro tubulomorphogenesis, which was associated with a dramatic reduction in vascular endothelial cadherin (VE-cadherin) at intercellular junctions...
  57. pmc Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation
    Yunhao Liu
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 182:185-96. 2008
    ..Shc activation and its vascular endothelial cadherin (VE-cadherin) association are matrix independent...
  58. ncbi Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells
    Yanqiu Liu
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 18:457-68. 2004
    ....
  59. pmc Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
    A Del Maschio
    Laboratory of Vascular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Cell Biol 135:497-510. 1996
    ..This effect could increase EC permeability and facilitate PMN transmigration during the acute inflammatory reaction...
  60. ncbi Role of Ca2+ signaling in the regulation of endothelial permeability
    Chinnaswamy Tiruppathi
    Department of Pharmacology M C868, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Vascul Pharmacol 39:173-85. 2002
    ..These results indicate that endothelial TRP channels such as TRPC1 and TRPC4 play an important role in signaling the increase in endothelial permeability...
  61. pmc Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Reprod Sci 16:479-88. 2009
    ..Endothelial junction protein vascular endothelial cadherin expression and distribution were examined by fluorescent staining of endothelial cells with or without ..
  62. ncbi Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase
    Hélène Hudry-Clergeon
    INSERM EMI 02 19, Laboratoire de Développement et Vieillissement de l Endothélium, Département Réponse Dynamique Cellulaire, Commissariat a l Energie Atomique, Grenoble Cedex 9, France
    FASEB J 19:512-20. 2005
    ..Physical association between PtdIns3'-kinase, serving as a docking protein, and VE-cadherin may thus provide an efficient mechanism for amplification and perpetuation of PAF-induced cellular activation...
  63. ncbi Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability
    Dorota Gabrys
    Department of Radiation Oncology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland
    Int J Radiat Oncol Biol Phys 69:1553-62. 2007
    ..To investigate the effects of radiation on the endothelial cytoskeleton and endothelial monolayer permeability and to evaluate associated signaling pathways, which could reveal potential mechanisms of known vascular effects of radiation...
  64. pmc A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    FASEB J 22:3310-7. 2008
    ..The ability of A6 to block retinal vascular permeability in diabetes suggests a potential therapeutic approach for the treatment of diabetic macular edema...
  65. ncbi Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability
    Fang Liao
    ImClone Systems Incorporated, New York, NY 10014, USA
    Cancer Res 62:2567-75. 2002
    ..Our data also suggest that antibody E4G10 recognizes VE-cadherin epitopes that are only accessible on endothelial cells forming new adherens junctions, such as in angiogenic tumor vasculature...
  66. ncbi Architecture of the VE-cadherin hexamer
    Elizabeth A Hewat
    Laboratoire de Microscopie Electronique Structurale, Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075, CEA CNRS UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Mol Biol 365:744-51. 2007
    ..In the context of the cell-cell junction these cis-trimers close to the membrane, and trans-dimers from opposing membranes, would increase the avidity of the bond...
  67. pmc Structure of artificial and natural VE-cadherin-based adherens junctions
    Jean Christophe Taveau
    CBMN UMR CNRS 5248 IECB, Universite Bordeaux 1, Avenue des Facultes, 33405 Talence, France
    Biochem Soc Trans 36:189-93. 2008
    In vascular endothelium, adherens junctions between endothelial cells are composed of VE-cadherin (vascular endothelial cadherin), an adhesive receptor that is crucial for the proper assembly of vascular structures and the maintenance of ..
  68. ncbi Serum erythropoietin and angiogenetic factors in human colorectal cancer
    A Chabowska
    Department of Medical, Medical University of Bialystok, Poland
    Prague Med Rep 108:348-57. 2007
    ..Therefore we aimed at measurement and comparison of serum erythropoietin with VEGF, VE-cadherin levels, blood haemoglobin and hematocrit in colorectal cancer patients of different clinicopathological profiles...
  69. ncbi An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds
    Matthias Festag
    Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Str 65, 88397 Biberach an der Riss, Germany
    Toxicol In Vitro 21:1631-40. 2007
    ....
  70. ncbi Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin
    Katrin Lamszus
    Department of Neurosurgery, Institute for Anatomy II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 11:4934-40. 2005
    ..In addition, we analyzed whether blockade of vascular endothelial (VE)-cadherin as a different antiangiogenic target could also inhibit glioblastoma angiogenesis and growth...
  71. pmc Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras
    Yingxiao Wang
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:1774-9. 2006
    ..The results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network...
  72. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009
    ..However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular development in which this protein is involved...
  73. doi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
    ..In endothelial cells, AJs are largely composed of vascular endothelial cadherin (VE-cadherin), an endothelium-specific member of the cadherin family of adhesion proteins that binds, ..
  74. pmc Kaposi's sarcoma-associated herpesvirus disrupts adherens junctions and increases endothelial permeability by inducing degradation of VE-cadherin
    Li Wu Qian
    Tumor Virology Program, Greehey Children s Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Virol 82:11902-12. 2008
    ..permeability was associated with the disruption of adherens junctions and the degradation of vascular endothelial cadherin (VE-cadherin) protein...
  75. ncbi Distribution of adherens junction mediated by VE-cadherin complex in rat spleen sinus endothelial cells
    Kiyoko Uehara
    Department of Cell Biology, Fukuoka University School of Medicine, Jonan ku, Fukuoka, 814 0180, Japan
    Cell Tissue Res 323:417-24. 2006
    ..These data suggest that adherens junctions, whose formation appears to be mediated by VE-cadherin-catenin complexes, probably regulate the passage of blood cells through the spleen...
  76. ncbi Putative intermediate precursor between hematogenic endothelial cells and blood cells in the developing embryo
    Stuart T Fraser
    Department of Molecular Genetics, Faculty of Medicine and Graduate School of Medicine, Kyoto University, Shogoin Kawaharacho 53, Sakyo ku, Japan
    Dev Growth Differ 45:63-75. 2003
    ..Collectively, these results introduce a novel VE-cadherin+ population within the developing embryo, which may represent an intermediate cell type in the transition of hemogenic endothelial cells into blood...
  77. ncbi Neutrophils induce sequential focal changes in endothelial adherens junction components: role of elastase
    Carmen V Ionescu
    Vascular Biology Inflammation Program, Lawson Health Research Institute, London, ON, Canada
    Microcirculation 10:205-20. 2003
    ..e., through endothelial cell-cell junctions. Herein, we assessed whether the adherens junctions (AJs) are disrupted during PMN transendothelial cell migration...
  78. ncbi Molecular organization of tight and adherens junctions in the human placental vascular tree
    L Leach
    School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, UK
    Placenta 21:547-57. 2000
    ..b>Vascular endothelial cadherin (VE-cadherin) clusters were co-localized with beta-catenin, an important signal transduction ligand, ..
  79. pmc Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin
    Punya Shrivastava-Ranjan
    Special Pathogens Branch, G 14, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Virol 84:11227-34. 2010
    ..These data implicate virus induction of VEGF and reduction in VE-cadherin in the endothelial cell permeability seen in HPS and suggest potential immunotherapeutic targets for the treatment of the disease...
  80. ncbi Adherens junctions in endothelial cells regulate vessel maintenance and angiogenesis
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Thromb Res 120:S1-6. 2007
    ....
  81. pmc Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin
    Ming Wei Chao
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicology 279:73-84. 2011
    ....
  82. doi Suppressing PTEN activity by tobacco smoke plus interleukin-1beta modulates dissociation of VE-cadherin/beta-catenin complexes in endothelium
    Silvia S Barbieri
    Department of Pharmacological Sciences, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 28:732-8. 2008
    ....
  83. ncbi The control of endothelial cell functions by adherens junctions
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Novartis Found Symp 283:4-13; discussion 13-7, 238-41. 2007
    ....
  84. ncbi Determination of microvessel density by quantitative real-time PCR in esophageal cancer: correlation with histologic methods, angiogenic growth factor expression, and lymph node metastasis
    Sonja Loges
    Department of Internal Medicine II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 13:76-80. 2007
    ..We compared MVD determination by immunohistology and quantitative real-time PCR and correlated the results with clinical variables...
  85. doi Confocal immunolocalization of VE-cadherin- and CXC chemokine-expressing endothelial cells in periapical granulomas
    O Takeichi
    Department of Endodontics, Nihon University School of Dentistry, Chiyoda ku, Tokyo, Japan
    Int Endod J 41:401-7. 2008
    ..To determine whether endothelial cells (ECs) in periapical granulomas can express vascular endothelial (VE)-cadherin, CXCL8 and CXCL10 by examining with two-colour confocal laser scanning microscope...
  86. doi Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice
    Georgios Foteinos
    Department of Cardiac and Vascular Sciences, St George s University of London, London, UK
    Circulation 117:1856-63. 2008
    ..In the present study, we investigated endothelial cell turnover and regeneration in apolipoprotein E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothelial TIE2 promoter...
  87. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
    ....
  88. pmc Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome
    Junlan Zhang
    Department of Internal Medicine and Liver Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Gastroenterology 136:1070-80. 2009
    ..Pentoxifylline (PTX) directly decreases lung endothelial Akt and eNOS activation, blocks intravascular monocyte accumulation, and improves experimental HPS; we evaluated whether pulmonary angiogenesis develops in this model...
  89. ncbi VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly
    Christopher V Crosby
    Cardiovascular Developmental Biology Center, Department of Cell Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Blood 105:2771-6. 2005
    ....
  90. ncbi Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells
    M Ogawa
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Blood 93:1168-77. 1999
    ..5 day postcoitum mouse embryos. Our results suggest that the expression of alpha4-integrin is a marker of the earliest precursor of hematopoietic cell lineage that was diverged from endothelial progenitors...
  91. ncbi Progenitor analysis of primitive erythropoiesis generated from in vitro culture of embryonic stem cells
    Takeshi Otani
    Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Exp Hematol 33:632-40. 2005
    ..In this study, we utilized our coculture system, in which ES-derived Flk-1+ cells differentiated into TER-119+ primitive erythroid (EryP) cells on OP9 cells, and looked for progenitors in primitive erythropoiesis...
  92. doi Preclinical development of tissue-engineered vein valves and venous substitutes using re-endothelialised human vein matrix
    O E Teebken
    Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Eur J Vasc Endovasc Surg 37:92-102. 2009
    ..This technique may enable causal treatment of venous reflux and obstructions...
  93. pmc Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
    Celeste M Nelson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 15:2943-53. 2004
    ....
  94. ncbi Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin
    Maria Konstantoulaki
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 285:L434-42. 2003
    The adherens junction is a multiprotein complex consisting of the transmembrane vascular endothelial cadherin (VEC) and cytoplasmic catenins (p120, beta-catenin, plakoglobin, alpha-catenin) responsible for the maintenance of endothelial ..
  95. doi Differentiation of multipotent adult germline stem cells derived from mouse testis into functional endothelial cells
    I Fen Cheng
    Department of Cardiology and Pulmonary Medicine, University of Goettingen, Goettingen, Germany
    J Vasc Res 49:207-20. 2012
    ..Thus, maGSCs may provide a useful source of endothelial-like cells to study the basic mechanisms of vasculogenesis or endothelial differentiation...
  96. pmc ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation
    Olga Tornavaca
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London EC1V 9EL, England, UK
    J Cell Biol 208:821-38. 2015
    ..ZO-1 is thus a central regulator of VE-cadherin-dependent endothelial junctions that orchestrates the spatial actomyosin organization, tuning cell-cell tension, migration, angiogenesis, and barrier formation. ..
  97. pmc VEGFR2 and Src kinase inhibitors suppress Andes virus-induced endothelial cell permeability
    Elena E Gorbunova
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Virol 85:2296-303. 2011
    ....
  98. pmc Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels
    Krishna Reddy
    Division of Pediatrics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 87, Houston, TX 77030, USA
    Mol Cancer Res 6:929-36. 2008
    ..network, and differentiated into cells expressing either endothelial markers (mouse CD31 or human vascular endothelial cadherin) or the pericyte markers desmin and alpha-smooth muscle actin...
  99. doi Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway
    Michael Bieri
    Laboratory for Heart Transplantation Immunology, Cardiology, Swiss Cardiovascular Center, University Hospital Inselspital, CH 3010 Bern, Switzerland
    Mol Immunol 46:866-72. 2009
    ..Herewith, we demonstrated that the expression of VE-cadherin is dependent on mTOR and PI3K signaling...
  100. ncbi Generation and characterisation of human saphenous vein endothelial cell lines
    Ariane Scoumanne
    Department of Vascular Surgery, Division of Surgery, Anaesthesia and Intensive Care, Imperial College School of Medicine, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    Atherosclerosis 160:59-67. 2002
    ..These cell lines expressed the known endothelial markers CD31 and vascular endothelial cadherin, and were able to bind Ulex europaeus lectin I, but they did not retain the expression of von ..
  101. doi Isolation and characterization of goat retinal microvascular endothelial cells
    Ravinarayanan Haribalaganesh
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University Kalasalingam Academy of Research and Education, Anand Nagar, Krishnankoil, 626 190, Tamilnadu, India
    In Vitro Cell Dev Biol Anim 46:529-37. 2010
    ..These endothelial cells will be more helpful to identify the role of various factors in angiogenic-related disease such as diabetic retinopathy...

Research Grants68

  1. CRIM1-b-Catenin-Cadherin Interactions in Eye Development and Disease
    RICHARD A contact LANG; Fiscal Year: 2010
    ..The down-regulation of cadherin expression and activity is also know to be a critical step in epithelial tumor progression as it allows tumor cells to leave the epithelium, become invasive and ultimately form metastases. ..
  2. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..This may lead to future discovery of a new therapeutic intervention for cardiovascular and cerebrovascular diseases. ..
  3. Regulation of endothelial adhesion by VE-cadherin endocytosis
    BENJAMIN ANDREW NANES; Fiscal Year: 2013
    ..In this application, we seek to investigate the role of endocytosis in the regulation of vascular endothelial cadherin (VE-cadherin), the main adhesion molecule in endothelial adherens junctions...
  4. Regulation of colitis by orphan nuclear receptor Nur77
    Dezheng Zhao; Fiscal Year: 2013
    ..Our studies have high impact by linking Nur77 to IBD pathogenesis and indicate vascular components of inflammation that could serve as therapeutic targets. ..
  5. Endothelial protease activity, organogenesis and birth defects
    Suneel S Apte; Fiscal Year: 2012
    ..The proposed work has immediate significance for common human birth defects, such as cleft palate and cardiac anomalies, and may provide new mouse models for other developmental defects. ..
  6. Therapeutic Interventions Against ANDV Induced Pathogenesis
    Erich R Mackow; Fiscal Year: 2013
    ..Here we will evaluate the efficacy of compounds that enhance EC barrier functions for their ability to prevent HPS-like disease in Syrian hamsters. ..
  7. High throughput screening of embryonic stem cell differentiation
    Ngan F Huang; Fiscal Year: 2010
    ..The potential impact of this research to public health is a reduction in mortality and morbidity among patients suffering from PAD. ..
  8. Vascular Sphingosine Kinase Signaling in Cerebral Ischemic Tolerance
    BRADLEY KENT WACKER; Fiscal Year: 2010
    ..Elucidating the mechanisms of neurovascular unit protection will facilitate the development of stroke therapeutics. ..
  9. Microvascular Endothelial Cells in the Pathogenesis of Chronic Kidney Injury
    Ikuyo Yamaguchi; Fiscal Year: 2011
    ..component of the inflammatory process leading to fibrosis, focusing on the adherens junction protein vascular endothelial cadherin (VE-cadherin) and its regulation by the angiogenic signaling molecule placental growth factor (PIGF)...
  10. Rho-mediated Signaling in Lung Endothelial Cells Induced by Neutrophil Adhesion
    KLAUS MICHAEL HAHN; Fiscal Year: 2013
    ..These studies may identify new targets for therapies in the treatment of inflammatory diseases. ..
  11. Contribution of the vascular niche to the hematopoietic reconstitution.
    Shahin Rafii; Fiscal Year: 2012
    ....
  12. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..Specific Aim 2: Investigate dose-response efficacy of Slit2N against ANDV. Specific Aim 3: Investigate efficacy of delayed therapy with Slit2N against ANDV. Specific Aim 4: Investigate efficacy of Slit2N in combination with ribavirin. ..
  13. The Role of the Vasculature in the Pathogenesis of Arthritis
    DEAN YAW LI; Fiscal Year: 2013
    ....
  14. Regulation of Wnt signaling by LPP3 (PAP2b) during angiogenesis
    Kishore K Wary; Fiscal Year: 2013
    ..The results of these investigations may reveal new therapeutic strategies to regulate angiogenesis, and the apoptotic properties of endothelial and tumor cells. ..
  15. Endothelial Plasticity in Human Disease
    Damian Medici; Fiscal Year: 2013
    ..This will allow us to further investigate the role of EndMT in vascular regression and other physiological or pathological processes in vivo. ..
  16. Shear regulated differentiation of hPSCs to brain endothelial cells
    Sean P Palecek; Fiscal Year: 2013
    ..Ascertain the effects of shear stress on hPSC-derived BMEC phenotype induction and maintenance 3. Determine the roles of PECAM-1 and VE-cadherin in shear-induced differentiation of BMECs ..
  17. Rap1 in VEGF signaling in endothelial cells
    Magdalena Chrzanowska-Wodnicka; Fiscal Year: 2013
    ..Knowledge gained through this research is expected to enable successful modulation of VEGF responses by manipulating specific Rap1 isoform activity. ..
  18. Orphan Nuclear Receptor TR3 in tumor angiogenesis and associated microvessel perm
    Huiyan Zeng; Fiscal Year: 2013
    ..The information from this study will not only enhance our understanding of the pathophyiosiology of tumorigenesis but also help us to develop effective therapeutic approaches for treatment of cancers. ..
  19. Integrins in the Endothelial Response to Fluid Shear Stress
    Martin A Schwartz; Fiscal Year: 2013
    ..2) identify the protein interactions that mediate adapter function by VE-cadherin. 3) examine vascular inflammation and atherogenesis in PAK-deficient mice. ..
  20. Rapid Heart Attack Detection using an AC Electrokinetic Device
    Rajaram Krishnan; Fiscal Year: 2011
    ..5 to 60.1 ng/mL and in MI patients from 113 to 909 ng/mL. Markers and antibody stains for identifying EMPs include CD144, von Willebrand Factor (vWF) and Ulex Europaeus Agluttin (UEA), a lectin stain...
  21. A mechanism for suppression of TNF induced endothelial dysfunction
    Arnold Johnson; Fiscal Year: 2013
    ..Thus, successful completion of the proposed studies may result in progress in treatment and prevention of advanced sepsis/ARDS. ..
  22. Regulation of vascular remodeling &angiogenesis by Nogo
    William C Sessa; Fiscal Year: 2013
    ..Mechanistically, the loss of Nogo suppresses ICAM-1 mediated signaling and the phosphorylation of VE cadherin in EC, which contributes to reduced inflammation in mice lacking Nogo-B...
  23. Cadherin Regulation in Dermal Endothelial Cells
    Andrew P Kowalczyk; Fiscal Year: 2013
    ..Completion of these studies will advance our understanding of cadherin based adhesion mechanisms and reveal possible therapeutic targets to regulate angiogenesis and inappropriate vascular regression. ..
  24. FIBRIN(OGEN) STRUCTURE AND INTERACTIONS
    LEONID V MEDVED; Fiscal Year: 2013
    ....
  25. Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
    Jerome W Breslin; Fiscal Year: 2013
    ..Discovery of targets that can be used to resolve microvascular hyperpermeability will revolutionize the treatment of trauma patients, and will also create new opportunities to treat edema associated with a wide range of diseases. ..
  26. The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration
    William A Muller; Fiscal Year: 2013
    ..The results of these studies will contribute significantly to our understanding of the regulation of diapedesis and provide new targets for anti-inflammatory therapy. ..
  27. Functional Genomics of the Cavernous Malformation Gene
    Murat Gunel; Fiscal Year: 2013
    ..The proposed experiments are focused on identifying the molecular pathways relevant to CCM disease and on studying these pathways in vivo with a long-term goal of defining new and more effective therapies. ..
  28. Endothelial cell junctions in mechanotransduction
    Eleni Tzima; Fiscal Year: 2012
    ..The proposed research will improve our understanding of why atherosclerosis plaques develop in specific regions in the vascular tree and may lead to development of therapies for cardiovascular disease and inflammation. ..
  29. Role of CD166/ALCAM in Lung Endothelial Barrier Function
    Solomon Ofori Acquah; Fiscal Year: 2007
    ..Blocking vascular endothelial cadherin function causes interstitial pulmonary edema, however normal endothelial cell junctions are formed in ..
  30. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ....
  31. FAK in E.coli Pathogenesis
    Lewis Romer; Fiscal Year: 2006
    ..coli K1 disease in the brain microvasculature. Insights into mechanisms of E .coli invasion that are gained here may provide useful paradigms for approaching E. coli disease in other organ systems. ..
  32. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  33. THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITY
    Asrar B Malik; Fiscal Year: 2012
    ..By more fully understanding the signaling mechanisms of reversal of increased vascular permeability, we will be better able to develop novel strategies to prevent vascular leakiness and formation of pulmonary edema. ..
  34. PHOSPHORYLATION AND ENDOTHELIAL NITRIC OXIDE PRODUCTION
    William C Sessa; Fiscal Year: 2013
    ....
  35. Non-canonical VEGF receptor signaling regulates retinal neovascularization
    MICHAEL EDWIN BOULTON; Fiscal Year: 2012
    ..Understanding this novel non-canonical VEGF signalling pathway(s) will provide new information on angiogenesis and allow development of a sustainable treatment strategy for AMD and diabetic retinopathy. ..
  36. The Role of the Stem Cell Niche in ALL
    Laura F Gibson; Fiscal Year: 2013
    ..Understanding the mechanisms by which the Ph+ leukemic stem cell is protected by the bone marrow microenvironment will increase our ability to design novel treatment strategies that are more effective in targeting this population. ..
  37. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2010
    ..abstract_text> ..
  38. BMP7 in melanoma niche morphogenesis and homeostasis
    Mei Yu Hsu; Fiscal Year: 2013
    ..identical to that of "vasculogenic mimicry (VM)";2) the vessel-like channels so formed in VM are themselves CD144 (VE-cadherin)+ and intimately associated with authentic endothelial structures, in keeping with so-called "..
  39. iPSC-Derived Endothelial Progenitor Cell Treatment of Lung Vascular Injury
    Asrar B Malik; Fiscal Year: 2013
    ....
  40. CRP, eNOS and Endothelial Dysfunction
    Philip W Shaul; Fiscal Year: 2010
    ..with mice expressing tamoxifen-inducible Cre-recombinase under the regulation of the vascular endothelial cadherin promoter (VECad-Cre-ERT2)...
  41. MODULATION OF THE ENDOTHELIUM BY THROMBIN AND SHEAR
    Marilyn Woolkalis; Fiscal Year: 2004
    ..The proposed research will provide foundation for examining problems of chronic vascular disease where the dysfunctional endothelium no longer appropriately regulates vascular permeability and vessel repair. ..
  42. P71 IN DERMAL MICROVASCULAR ENDOTHELIAL JUNCTION ASSEMBL
    Andrew Kowalczyk; Fiscal Year: 2001
    ..These studies are designed to provide the basis for an individual research proposal focusing on the role of this novel arm protein in dermal microvascular endothelial barrier function and neovascularization. ..
  43. Slit2N for the Treatment of Viral Hemorrhagic Fever
    ALAN L MUELLER; Fiscal Year: 2012
    ..With this information, we would then expect to meet with the FDA in a pre-IND meeting to discuss the final preclinical requirements and future clinical path. ..
  44. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2013
    ..These studies will provide insight into the cell-specific locations where ROS and redox signaling modulate coronary collateral growth. ..
  45. Endothelial Barrier Function Regulation by VEGF
    David Cheresh; Fiscal Year: 2009
    ..These studies not only offer new insight into the role that VEGF and Src play in vascular biology and cancer but suggest a new therapeutic strategy to block VEGF-mediated vascular permeability as a means to regulate metastatic disease. ..
  46. MECHANISMS OF VASCULAR BARRIER REGULATION
    Kane Schaphorst; Fiscal Year: 2001
    ..End of abstract) ..
  47. ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES
    FRANCIS LUSCINSKAS; Fiscal Year: 2003
    ..Specific Aim 3 will utilize in vivo models of chronic inflammation or immune reactions to test the potential role of human JAM in leukocyte recruitment. ..
  48. p120 catenin in vascular endothelial homeostasis
    Hazel Lum; Fiscal Year: 2009
    ..In this proposal, we seek to better understand how a healthy vasculature is controlled in tissues, which is vital to better design treatments to prevent or reverse pathological disease processes. ..
  49. The role of endothelial progenitor cells in tumor growth and metastasis
    Vivek Mittal; Fiscal Year: 2013
    ..These experiments can lead to the development of targeted therapies which can reduce primary tumor growth and metastatic burden with the hope of extending the lives of patients with aggressive cancers. ..
  50. Immune evasion by gamma 2 Herpesviruses
    KLAUS J FRUEH; Fiscal Year: 2010
    ..abstract_text> ..
  51. Microvascular Barrier Dysfunction in Thermal Injury
    Sarah Y Yuan; Fiscal Year: 2013
    ..Information gleaned from the study will significantly advance our understanding of microvascular pathobiology following thermal injury, with the potential to be translated to clinical practice for improved patient care. ..
  52. Downstream of Akt in the tumor vessel
    William C Aird; Fiscal Year: 2012
    ..We anticipate our findings to be relevant not only to the management of tumor progression but to have particular applications in preventing metastasis ..
  53. PKC Isoenzymes and Diabetic Microvascular Hyperpermeability
    Sarah Y Yuan; Fiscal Year: 2010
    ..abstract_text> ..
  54. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2007
    ....
  55. Endotoxin TLR4 Signaling Regulates Lung Endothelial Paracellular Pathway
    SIMEON EMANUEL GOLDBLUM; Fiscal Year: 2012
    ..abstract_text> ..
  56. Role of End Binding 3 in Mechanism of vascular permeability
    Yulia A Komarova; Fiscal Year: 2013
    ..We will exploit state of the art technologies including live cell imaging, expression of mutant constructs, gene transfer, and murine models of lung inflammation to accomplish the specific aims. ..
  57. SHEAR STRESS ACTIVATION OF ENDOTHELIAL MEMBRANE FUNCTION
    John A Frangos; Fiscal Year: 2013
    ..abstract_text> ..
  58. Effects of Sema3A-Nrp1 signaling on tumor cell extravastion and metastasis
    LISETTE MARIE ACEVEDO; Fiscal Year: 2013
    ..Understanding how mediators of vascular permeability can affect tumor extravasation and metastasis is required to design novel approaches to control metastatic disease. ..
  59. SHEAR STRESS MODULATION OF ENDOTHELIAL WOUND HEALING
    MARIA LUIZA ALBUQUERQUE; Fiscal Year: 2003
    ..Investigation of the mechanisms underlying endothelial repair during shear stress may lead to better strategies for the management of patients suffering from a variety of cardiovascular disorders. ..
  60. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    ..abstract_text> ..
  61. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2006
    ..the role of Vascular Endothelial Growth Factor (VEGF) on the inflammatory changes and the reorganization of VE cadherin that occur during ductus remodeling...
  62. MECHANISMS OF INFLAMMATORY EDEMA
    DOUGLAS SHASBY; Fiscal Year: 2005
    ..We will use this model to determine if histamine alters cadherin-based adhesion due to effects within the cadherin-catenin complex. ..
  63. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2009
    ..abstract_text> ..
  64. BIOLOGICAL STUDIES IN KAPOSI'S SARCOMA
    PHILIP BROWNING; Fiscal Year: 2000
    ..The results from these studies will advance our knowledge of KS pathogenesis, HHV-8 viral tropism, and hopefully improve our staging and ability to monitor AIDS-KS disease response. ..
  65. Development of a BioMIMETIC Composite Scaffold to promote vascular network growth
    David A Rubenstein; Fiscal Year: 2013
    ..We have put together a research team that has the expertise and drive to successfully address this important question. ..
  66. p120 catenin/VE-cadherin interaction in angiogenesis
    Andres Ferber; Fiscal Year: 2005
    ..These studies will help elucidate the basic biochemical and biological responses by which the interaction between VE-cadherin and p120ctn may modulate angiogenesis...
  67. VASCULAR ENDOTHELIAL CADHERIN FUNCTION IN INFLAMMATION
    SUNIL SHAW; Fiscal Year: 2003
    ..b>Vascular endothelial cadherin is located at endothelial adherens and junctions and may regulate monolayer permeability to leukocytes ..
  68. PKA in Reduction of Endothelial Permeability
    Hazel Lum; Fiscal Year: 2006
    ....