VDAC2

Summary

Gene Symbol: VDAC2
Description: voltage dependent anion channel 2
Alias: POR, voltage-dependent anion-selective channel protein 2, outer mitochondrial membrane protein porin 2
Species: human
Products:     VDAC2

Top Publications

  1. De Pinto V, Guarino F, Guarnera A, Messina A, Reina S, Tomasello F, et al. Characterization of human VDAC isoforms: a peculiar function for VDAC3?. Biochim Biophys Acta. 2010;1797:1268-75 pubmed publisher
    ..Real-time PCR comparison of the isoforms indicated that in HeLa cells VDAC1 is 10 times more abundant than VDAC2 and 100 times than VDAC3...
  2. Yu T, Raschle T, Hiller S, Wagner G. Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochim Biophys Acta. 2012;1818:1562-9 pubmed publisher
    ..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism...
  3. Maurya S, Mahalakshmi R. Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions. J Biol Chem. 2013;288:25584-92 pubmed publisher
    ..Such subtle sequence variations contribute to differential stability of VDACs and may have implications in their in vivo regulation and recycling. ..
  4. Cheng E, Sheiko T, Fisher J, Craigen W, Korsmeyer S. VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science. 2003;301:513-7 pubmed
    ..In viable cells, we found BAK complexed with mitochondrial outer-membrane protein VDAC2, a VDAC isoform present in low abundance that interacts specifically with the inactive conformer of BAK...
  5. Hinsch K, De Pinto V, Aires V, Schneider X, Messina A, Hinsch E. Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum. J Biol Chem. 2004;279:15281-8 pubmed
    ..Peptide sequences were found to match VDAC2 and VDAC3...
  6. Blachly Dyson E, Zambronicz E, Yu W, Adams V, McCabe E, Adelman J, et al. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. J Biol Chem. 1993;268:1835-41 pubmed
    ..The expression of each human cDNA has been assessed by Northern blot and polymerase chain reaction techniques. With one exception, each is expressed in all human cell lines and tissues examined. ..
  7. Li Z, Wang Y, Xue Y, Li X, Cao H, Zheng S. Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via interaction with VP5. J Virol. 2012;86:1328-38 pubmed publisher
    ..5 (VP5) is a major apoptosis inducer in DF-1 cells by interacting with the voltage-dependent anion channel 2 (VDAC2) in the mitochondrion...
  8. Liu B, Wang Z, Zhang W, Wang X. Expression and localization of voltage-dependent anion channels (VDAC) in human spermatozoa. Biochem Biophys Res Commun. 2009;378:366-70 pubmed publisher
    ..Our study elucidated for the first time that VDAC were synthesized and secreted at the testis level and eventually became an integral part of sperm proteins. ..
  9. Chin H, Li M, Tan I, Ninnis R, Reljic B, Scicluna K, et al. VDAC2 enables BAX to mediate apoptosis and limit tumor development. Nat Commun. 2018;9:4976 pubmed publisher
    ..From an unbiased genome-wide CRISPR/Cas9 screen, we identified VDAC2 (voltage-dependent anion channel 2) as important for BAX, but not BAK, to function...

More Information

Publications86

  1. Schredelseker J, Paz A, Lopez C, Altenbach C, Leung C, Drexler M, et al. High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population. J Biol Chem. 2014;289:12566-77 pubmed publisher
    In recent years, there has been a vast increase in structural and functional understanding of VDAC1, but VDAC2 and -3 have been understudied despite having many unique phenotypes...
  2. Srivastava S, Zadafiya P, Mahalakshmi R. Hydrophobic Mismatch Modulates Stability and Plasticity of Human Mitochondrial VDAC2. Biophys J. 2018;115:2386-2394 pubmed publisher
    ..We propose that VDAC plasticity and stability in the mitochondrial outer membrane are modulated by physical properties of the bilayer. ..
  3. Long M, Zhao J, Li T, Tafalla C, Zhang Q, Wang X, et al. Transcriptomic and proteomic analyses of splenic immune mechanisms of rainbow trout (Oncorhynchus mykiss) infected by Aeromonas salmonicida subsp. salmonicida. J Proteomics. 2015;122:41-54 pubmed publisher
    ..Consequently, these upregulated proteins, namely, ferritin, CD209, IL13Rα1, VDAC2, GIMAP7, PSMA1, and two ANXA11s could be considered as potential biomarkers for rainbow trout immune responses...
  4. Chen Y, Liu Y, Lan T, Qin W, Zhu Y, Qin K, et al. Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe. J Am Chem Soc. 2018;140:4712-4720 pubmed publisher
    ..and validated a novel cysteine site of modification on voltage-dependent anion-selective channel protein 2 (VDAC2) that might play an important role in sensitizing LDE signals and mediating ferroptosis...
  5. Aono Y, Horinaka M, Iizumi Y, Watanabe M, Taniguchi T, Yasuda S, et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun. 2018;505:1203-1210 pubmed publisher
    ..we identified mitochondrial outer membrane proteins voltage-dependent anion channel (VDAC) 1 and VDAC2 as novel molecular targets of sulindac sulfone, and sulindac sulfone directly bound to both VDAC1 and VDAC2...
  6. Miyata N, Okumoto K, Fujiki Y. Cell Death or Survival Against Oxidative Stress. Subcell Biochem. 2018;89:463-471 pubmed publisher
    ..A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, ..
  7. Yao G, Zhu Q, Xia J, Chen F, Huang M, Liu J, et al. Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia. Cell Death Dis. 2018;9:1033 pubmed publisher
    ..Here, we showed that the expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1 subfield after global ischemia...
  8. Hosaka T, Okazaki M, Kimura Someya T, Ishizuka Katsura Y, Ito K, Yokoyama S, et al. Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1. Protein Sci. 2017;26:1749-1758 pubmed publisher
    ..that by having multiple patterns of interaction, VDAC1 can form homo- or hetero-oligomers not only with other VDAC1 protomers but also with other proteins such as VDAC2, VDAC3 and apoptosis-regulating proteins in the Bcl-2 family.
  9. Prasad M, Kaur J, Pawlak K, Bose M, Whittal R, Bose H. Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction. J Biol Chem. 2015;290:2604-16 pubmed publisher
    ..Here, we report for the first time that StAR interacts with voltage-dependent anion channel 2 (VDAC2) at the mitochondria-associated endoplasmic reticulum membrane (MAM) prior to its translocation to the ..
  10. Asmarinah A, Paradowska Dogan A, Kodariah R, Tanuhardja B, Waliszewski P, Mochtar C, et al. Expression of the Bcl-2 family genes and complexes involved in the mitochondrial transport in prostate cancer cells. Int J Oncol. 2014;45:1489-96 pubmed
    ..e., pro-apoptotic Bak and Bid, and anti-apoptotic Bcl-2; VDAC gene, i.e., VDAC1, VDAC2 and VDAC3; and TOMM genes, i.e., TOMM20, TOMM22 and TOMM40...
  11. Bruderer R, Bernhardt O, Gandhi T, Miladinović S, Cheng L, Messner S, et al. Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues. Mol Cell Proteomics. 2015;14:1400-10 pubmed publisher
    ..The adducts were identified on four mitochondrial oxidative stress related proteins (GATM, PARK7, PRDX6, and VDAC2) and two other proteins (ANXA2 and FTCD)...
  12. Nascimento T, Silva M, Miyabara E. BGP-15 improves contractile function of regenerating soleus muscle. J Muscle Res Cell Motil. 2018;39:25-34 pubmed publisher
    ..Although BGP-15 did not alter voltage dependent anion-selective channel 2 (VDAC2) expression in cryolesioned muscles, it was able to increase inducible 70-kDa heat shock protein (HSP70) ..
  13. Saletti R, Reina S, Pittalà M, Magrí A, Cunsolo V, Foti S, et al. Post-translational modifications of VDAC1 and VDAC2 cysteines from rat liver mitochondria. Biochim Biophys Acta Bioenerg. 2018;1859:806-816 pubmed publisher
    VDACs three isoforms (VDAC1, VDAC2, VDAC3) are integral proteins of the outer mitochondrial membrane whose primary function is to permit the communication and exchange of molecules related to the mitochondrial functions...
  14. Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, et al. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 2018;28:833-854 pubmed publisher
    ..This promotes the formation of ER-mitochondria contacts through EI24 and the mitochondrial outer membrane protein VDAC2, facilitates Ca2+ transfer from ER to mitochondria and promotes DNA damage-induced apoptosis...
  15. Lü A, Hu X, Li L, Pei C, Zhang C, Cao X, et al. Tissue distribution of olive flounder VDAC2 and its expression in fish cell lines. Fish Physiol Biochem. 2015;41:899-907 pubmed publisher
    ..In this study, the tissue distribution of olive flounder Paralichthys olivaceus VDAC2 (PoVDAC2) was detected by quantitative real-time PCR and Western blot analysis...
  16. Chang J, Chi S. GHSC70 is involved in the cellular entry of nervous necrosis virus. J Virol. 2015;89:61-70 pubmed publisher
    ..By performing an immunoprecipitation assay, we confirmed that GHSC70 interacted with NNV capsid protein, while VDAC2 did not...
  17. Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, et al. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. elife. 2015;4: pubmed publisher
    ..We show that efsevin binds to VDAC2, potentiates mitochondrial Ca(2+) uptake and accelerates the transfer of Ca(2+) from intracellular stores into ..
  18. Xu A, Hua Y, Zhang J, Chen W, Zhao K, Xi W, et al. Abnormal Hypermethylation of the VDAC2 Promoter is a Potential Cause of Idiopathic Asthenospermia in Men. Sci Rep. 2016;6:37836 pubmed publisher
    This study aimed to explore the association between the methylation status of the VDAC2 gene promoter region and idiopathic asthenospermia (IAS). Twenty-five IAS patients and 27 fertile normozoospermia (NZ) were involved...
  19. Ma S, Nguyen T, Tan I, Ninnis R, Iyer S, Stroud D, et al. Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function. Cell Death Differ. 2014;21:1925-35 pubmed publisher
    ..During apoptosis, Bax dissociates from VDAC2 and homo-oligomerizes to form high molecular weight oligomers...
  20. Okazaki M, Kurabayashi K, Asanuma M, Saito Y, Dodo K, Sodeoka M. VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore. Biochim Biophys Acta. 2015;1848:3188-96 pubmed publisher
    The voltage-dependent anion channels (VDACs), VDAC1, VDAC2, and VDAC3, are pore-forming proteins that control metabolite flux between mitochondria and cytoplasm...
  21. Checchetto V, Reina S, Magrì A, Szabo I, De Pinto V. Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance. Cell Physiol Biochem. 2014;34:842-53 pubmed publisher
    ..While the pore-forming ability of recombinant VDAC1 and VDAC2 has been extensively studied during the last decades, a clear-cut ion conducting channel activity has not been ..
  22. Leone A, Roca M, Ciardiello C, Terranova Barberio M, Vitagliano C, Ciliberto G, et al. Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway. Free Radic Biol Med. 2015;89:287-99 pubmed publisher
    ..of the expression of both the enzyme hexokinase1, a negative VDAC1 regulator, and the anti-apoptotic porin VDAC2, only in the combination setting, suggesting convergent mechanisms that enhanced mitochondria-dependent apoptosis ..
  23. Lai X, Chen S. Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. Cancer Genomics Proteomics. 2015;12:271-81 pubmed
    ..A comprehensive approach to prioritize the biomarker candidates by category and rank revealed CD63, DDB1, TYMP, VDAC2, and DCXR as the top five biomarker candidates...
  24. Indo H, Tomiyoshi T, Suenaga S, Tomita K, Suzuki H, Masuda D, et al. MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1. J Clin Biochem Nutr. 2015;57:98-104 pubmed publisher
    ..results revealed that microgravity did not result in significant changes except for a upregulation of proapoptotic VDAC2, and downregulations of proapoptotic CASP9 and antiapoptotic MnSOD. After 0...
  25. Li Y, Zhang L, Qu T, Li L, Zhang G. Characterization of Oyster Voltage-Dependent Anion Channel 2 (VDAC2) Suggests Its Involvement in Apoptosis and Host Defense. PLoS ONE. 2016;11:e0146049 pubmed publisher
    ..In this study, we focused on a representative apoptotic gene encoding voltage-dependent anion channel 2 (VDAC2), a porin that abounds at the mitochondrial outer membrane...
  26. Naghdi S, Hajnoczky G. VDAC2-specific cellular functions and the underlying structure. Biochim Biophys Acta. 2016;1863:2503-14 pubmed publisher
    Voltage Dependent Anion-selective Channel 2 (VDAC2) contributes to oxidative metabolism by sharing a role in solute transport across the outer mitochondrial membrane (OMM) with other isoforms of the VDAC family, VDAC1 and VDAC3...
  27. Chipuk J, Luna Vargas M. The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family. J Cell Biol. 2017;216:547-549 pubmed publisher
    Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb...
  28. Ye F, Wang J, Meng W, Qian J, Jin M. Proteomic investigation of effects of hydroxysafflor yellow A in oxidized low-density lipoprotein-induced endothelial injury. Sci Rep. 2017;7:17981 pubmed publisher
    ..We also analysed the role of the mitochondrial membranous voltage-dependent anion-selective channel protein 2 (VDAC2) in HSYA treatment using small interfering RNA...
  29. Lauterwasser J, Todt F, Zerbes R, Nguyen T, Craigen W, Lazarou M, et al. The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation. Sci Rep. 2016;6:32994 pubmed publisher
    ..We further discover the mitochondrial porin voltage-dependent anion channel 2 (VDAC2) as essential component and platform for Bax retrotranslocation...
  30. Xing W, Yuan T, Xu J, Gu L, Liang P, Lu H. Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model. Environ Toxicol Pharmacol. 2015;40:592-9 pubmed publisher
    ..pyruvate dehydrogenase E1 component subunit beta (PDH-β), voltage-dependent anion-selective channel protein 2 (VDAC2), voltage-dependent anion-selective channel protein 1 (VDAC1), adenylate kinase 2 (KAD2) and others...
  31. Majumder S, Cash A, Fisk H. Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis. Cells. 2015;4:331-53 pubmed publisher
    ..We show here that the other two family members, VDAC1 and VDAC2, best known for their function in mitochondrial bioenergetics, are also found at centrosomes...
  32. GÅ‚ombik K, Stachowicz A, Åšlusarczyk J, Trojan E, Budziszewska B, Suski M, et al. Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats. Psychoneuroendocrinology. 2015;60:151-62 pubmed publisher
    ..pyruvate dehydrogenase E1 component subunit beta, the voltage-dependent anion-selective channel protein 2 (VDAC2), and the GTP-binding nuclear protein RAN (RAN) were down-regulated and the expression of phosphatidylethanolamine-..
  33. Lei T, Wang H, Li F, Cui Y, Fu F, Li R, et al. De Novo 1.77-Mb Microdeletion of 10q22.2q22.3 in a Girl With Developmental Delay, Speech Delay, Congenital Cleft Palate, and Bilateral Hearing Impairment. Cleft Palate Craniofac J. 2017;54:343-350 pubmed publisher
    ..2q22.3. The deletion harbors 9 genes, including KAT6B, DUPD1, DUSP13, SAMD8, VDAC2, COMTD1, ZNF503, NCRNA00245, and C10orf11. This is the first patient with a deletion of the smallest size in 10q22...
  34. Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Autophagy. 2015;11:1081-98 pubmed publisher
    ..Here, we reveal an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary...
  35. Hosoi K, Miyata N, Mukai S, Furuki S, Okumoto K, Cheng E, et al. The VDAC2-BAK axis regulates peroxisomal membrane permeability. J Cell Biol. 2017;216:709-722 pubmed publisher
    ..Using a functional screening strategy, VDAC2 was identified as rescuing the peroxisomal deficiency of ZP114 where VDAC2 expression was not detected...
  36. Subedi K, Kim J, Kang M, Son M, Kim Y, Woo S. Voltage-dependent anion channel 2 modulates resting Ca²+ sparks, but not action potential-induced Ca²+ signaling in cardiac myocytes. Cell Calcium. 2011;49:136-43 pubmed publisher
    ..In this study, we have investigated the possible role of type 2 VDAC (VDAC2) in cardiac Ca(2+) signaling and Ca(2+) sparks using a lentiviral knock-down (KD) technique and two-dimensional ..
  37. Pan L, Qiu D, Li J, Li J, Xu P, Zhao D, et al. Idiopathic male infertility in the Han population in China is affected by polymorphism in the VDAC2 gene. Oncotarget. 2016;7:82594-82601 pubmed publisher
    It has been proved that human voltage-dependent anion channel 2 (VDAC2) plays a significant role in sperm function and male fertility...
  38. Caterino M, Ruoppolo M, Mandola A, Costanzo M, Orru S, Imperlini E. Protein-protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms. Mol Biosyst. 2017;13:2466-2476 pubmed publisher
    ..The interactions involving VDAC1 have been characterized more in depth than those involving VDAC2 and VDAC3...
  39. Valis K, Neubauerova J, Man P, Pompach P, Vohradsky J, Kovar J. VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation. Mol Cell Biochem. 2008;311:225-31 pubmed publisher
    ..e., aldolase A (ALDA) and voltage-dependent anion channel 2 (VDAC2)...
  40. Lin W, Zhang Z, Xu Z, Wang B, Li X, Cao H, et al. The association of receptor of activated protein kinase C 1(RACK1) with infectious bursal disease virus viral protein VP5 and voltage-dependent anion channel 2 (VDAC2) inhibits apoptosis and enhances viral replication. J Biol Chem. 2015;290:8500-10 pubmed publisher
    ..previous report indicates that IBDV VP5 induces apoptosis via interaction with voltage-dependent anion channel 2 (VDAC2). However, the underlying molecular mechanism is still unclear...
  41. Chandra D, Choy G, Daniel P, Tang D. Bax-dependent regulation of Bak by voltage-dependent anion channel 2. J Biol Chem. 2005;280:19051-61 pubmed
    ..However, the oligomeric VDAC-2 complexes are diminished, and Bak does not interact with VDAC-2 in Bax-deficient HCT116 cells. These results highlight VDAC-2 as a critical inhibitor of Bak-mediated apoptotic responses. ..
  42. Tanno M, Kuno A, Ishikawa S, Miki T, Kouzu H, Yano T, et al. Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2). J Biol Chem. 2014;289:29285-96 pubmed publisher
    ..MALDI-TOF/MS analysis revealed that one of the spots contained voltage-dependent anion channel 2 (VDAC2)...
  43. Engelhardt H, Meins T, Poynor M, Adams V, Nussberger S, Welte W, et al. High-level expression, refolding and probing the natural fold of the human voltage-dependent anion channel isoforms I and II. J Membr Biol. 2007;216:93-105 pubmed
    ..Our analysis strongly suggests a 16-stranded, antiparallel beta-barrel with one large and seven short loops and turns. Initial crystallization trials of the protein yielded crystals diffracting to 8 Angstrom resolution. ..
  44. Liu B, Wang P, Wang Z, Zhang W. The use of anti-VDAC2 antibody for the combined assessment of human sperm acrosome integrity and ionophore A23187-induced acrosome reaction. PLoS ONE. 2011;6:e16985 pubmed publisher
    ..In this study, we focused on the presence of VDAC2 in human spermatozoa and its possible role in the acrosomal integrity and acrosome reaction using specific anti-..
  45. Zhu B, Zhai J, Zhu H, Kyprianou N. Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling. Prostate. 2010;70:17-26 pubmed publisher
    ..These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via Smad-dependent pathway (apoptosis) and MAPK intracellular signaling (survival). ..
  46. Decker W, Bowles K, Schatte E, Towbin J, Craigen W. Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis. Mamm Genome. 1999;10:1041-2 pubmed
  47. Mannella C. Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications. J Struct Biol. 1998;121:207-18 pubmed
    ..Partial closure would result from subsequent larger-scale structural rearrangements in the protein, possibly corresponding to the conformational change observed at pH < 5. ..
  48. Maurya S, Mahalakshmi R. Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial ?-barrel anion channel hVDAC-2. PLoS ONE. 2014;9:e92183 pubmed publisher
    ..Our results indicate that the nine cysteine residues of hVDAC-2 are the key in establishing strong(er) barrel interactions with its environment and also impart additional malleability to the barrel scaffold. ..
  49. Rosenberger D, Falangola M, Ledreux A, Nie X, Suhre W, Boger H, et al. Memory and hippocampal architecture following short-term midazolam in western diet-treated rats. Neurosci Lett. 2016;621:68-74 pubmed publisher
    ..an overall increase of kurtosis metrics in the hippocampus and increased expression of the mitochondrial protein VDAC2 in midazolam-treated rats...
  50. Blachly Dyson E, Baldini A, Litt M, McCabe E, Forte M. Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. Genomics. 1994;20:62-7 pubmed
    ..Here, we report the mapping of VDAC1 to the X chromosome in the interval Xq13-q21 and VDAC2 to chromosome 21 by polymerase chain reaction and restriction analysis of a human/rodent somatic cell mapping ..
  51. Maurya S, Mahalakshmi R. N-helix and Cysteines Inter-regulate Human Mitochondrial VDAC-2 Function and Biochemistry. J Biol Chem. 2015;290:30240-52 pubmed publisher
    ..The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs. ..
  52. Mato E, Barceló Batllori S, Orera I, Selva L, Corra M, González C, et al. The proteomic 2D-DIGE approach reveals the protein voltage-dependent anion channel 2 as a potential therapeutic target in epithelial thyroid tumours. Mol Cell Endocrinol. 2015;404:37-45 pubmed publisher
    We investigated the role of VDAC2 in human epithelial thyroid tumours using proteomic 2D-DIGE analysis and qRT-PCR. We found a significant up-regulation of VDAC2 in thyroid tumours and in thyroid tumour cell lines (TPC-1 and CAL-62)...
  53. Naghdi S, Várnai P, Hajnóczky G. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis. Proc Natl Acad Sci U S A. 2015;112:E5590-9 pubmed publisher
    ..However, only Vdac2(-/-) (V2(-/-)) mice are embryonic lethal, indicating a unique and fundamental function of VDAC2 (V2)...
  54. Messina A, Oliva M, Rosato C, Huizing M, Ruitenbeek W, van den Heuvel L, et al. Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered. Biochem Biophys Res Commun. 1999;255:707-10 pubmed
    ..The sequence of the probe extremities clearly pointed to a genuine VDAC genomic sequence. Human and mouse regions where VDAC 1 and 2 genes were mapped are known to be synthetic, thus reinforcing the mapping of the human homologues. ..
  55. Lee M, Kim J, Suk K, Park J. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol. 2004;24:3918-27 pubmed
    ..Taken together, our data indicate that HGTD-P is a new HIF-1 alpha-responsive proapoptotic molecule that activates mitochondrial apoptotic cascades. ..
  56. Yang X, Tang S, Li D, Li B, Xiao X. ROS-mediated oligomerization of VDAC2 is associated with quinocetone-induced apoptotic cell death. Toxicol In Vitro. 2018;47:195-206 pubmed publisher
    ..regulating QCT-induced apoptotic cell death has been established, the role of voltage dependent anion channel 2 (VDAC2) in QCT-induced toxicity remains unclear...
  57. Huang H, Shah K, Bradbury N, Li C, White C. Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation. Cell Death Dis. 2014;5:e1482 pubmed publisher
    ..Mcl-1 bound with high affinity to VDAC1 and 3 isoforms but only very weakly to VDAC2 and binding was disrupted by peptides based on the VDAC1 sequence...
  58. González Durruthy M, Werhli A, Seus V, Machado K, Pazos A, Munteanu C, et al. Decrypting Strong and Weak Single-Walled Carbon Nanotubes Interactions with Mitochondrial Voltage-Dependent Anion Channels Using Molecular Docking and Perturbation Theory. Sci Rep. 2017;7:13271 pubmed publisher
    ..nanotoxicity) between VDAC mitochondrial channels of three species (VDAC1-Mus musculus, VDAC1-Homo sapiens, VDAC2-Danio rerio) with SWCNT-H, SWCNT-OH, SWCNT-COOH carbon nanotubes...
  59. Alvira C, Umesh A, Husted C, Ying L, Hou Y, Lyu S, et al. Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production. Am J Respir Cell Mol Biol. 2012;47:669-78 pubmed publisher
    ..Depletion of VDAC2, but not VDAC1, blocked the agonist-induced increase in eNOS activity in hPAECs...
  60. Maurya S, Mahalakshmi R. Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities. Biol Rev Camb Philos Soc. 2017;92:1843-1858 pubmed publisher
    ..The primary role of VDACs is metabolite flux. The pro- and anti-apoptotic role of VDAC1 and VDAC2, respectively, are secondary, and are influenced by external factors and interacting proteins...
  61. Sotgia F, Fiorillo M, Lisanti M. Mitochondrial markers predict recurrence, metastasis and tamoxifen-resistance in breast cancer patients: Early detection of treatment failure with companion diagnostics. Oncotarget. 2017;8:68730-68745 pubmed publisher
    ..17 (p=2.2e-07). These include mitochondrial chaperones (HSPD1, HSPA9), membrane proteins (VDAC2, TOMM70A) and anti-oxidants (SOD2), as well as 18 different mitochondrial ribosomal proteins (MRPs) and >20 ..
  62. Sun Y, Vashisht A, Tchieu J, Wohlschlegel J, Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem. 2012;287:40652-60 pubmed publisher
    ..We hypothesize that VDACs serve as mitochondrial docking sites to recruit Parkin from the cytosol to defective mitochondria. ..
  63. Ha H, Hajek P, Bedwell D, Burrows P. A mitochondrial porin cDNA predicts the existence of multiple human porins. J Biol Chem. 1993;268:12143-9 pubmed
    ..Taken together, these results suggest that multiple porin proteins can be expressed in humans. Additionally, a porin consensus protein sequence has been identified that is conserved in eukaryotic organisms as diverse as yeast and man. ..
  64. Petit F, Serres C, Bourgeon F, Pineau C, Auer J. Identification of sperm head proteins involved in zona pellucida binding. Hum Reprod. 2013;28:852-65 pubmed publisher
    ..various proteins, including glutathione S-transferase M3 (GSTM) with ZPB/4 and voltage-dependent anion channel 2 (VDAC2) with ZPA/2 and ZPC/3...
  65. Petit E, Cartron P, Oliver L, Vallette F. The phosphorylation of Metaxin 1 controls Bak activation during TNF? induced cell death. Cell Signal. 2017;30:171-178 pubmed publisher
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    ..ribonucleoprotein (hnRNP) F, guanine nucleotide binding protein (G protein), voltage-dependent anion channel 2 (VDAC2) and cytochrome bc1 were present in abundance in the NiV-infected SK-N-MC cells in contrast to hnRNPs H and H2 ..
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    ..These results suggest that the gelsolin G5 domain inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC, and might be used as a protective treatment against HIV-Vpr-induced T-cell apoptosis. ..
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    ..Moreover, the PPT1 IP implicate the enzyme in novel roles including: involvement in neuronal migration and dopamine receptor mediated signalling pathway. ..
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    ..real-Time PCR demonstrated that three VDAC mRNAs were present in mature spermatozoa. The VDAC2 mRNA level in ejaculated spermatozoa of patients was significantly higher than that of donors...
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    ..VDAC1 (SWISS-PROT accession number P21796) and VDAC2 (P45880) were unambiguously identified and quantified, but VDAC3 was not found...
  73. Martínez Abad S, Castillo Martin M, Gadani B, Rodriguez Gil J, Bonet S, Yeste M. Voltage-dependent anion channel 2 is involved in in vitro capacitation of boar sperm. Reprod Domest Anim. 2017;52 Suppl 4:65-68 pubmed publisher
    ..Given that voltage-dependent anion channel 2 (VDAC2) is present in boar spermatozoa and is known to be involved in calcium transport in somatic cells, this study ..
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    ..G6PD), cytochrome b-c1 complex subunit 1 (UQCRC1), and voltage-dependent anion-selective channel protein 2 (VDAC2) as highly sensitive biomarkers to predict BPA-mediated diseases...
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    ..Non-specific binding was inconsistent and involved various types of proteins underlining the importance of reproducibility and control experiments in proteomic studies. ..
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    ..Moreover, most disease-relevant mutations of Parkin hinder this event and endogenous HKI is ubiquitylated upon dissipation of mitochondrial membrane potential in genuine-Parkin expressing cells, suggesting its physiological importance. ..
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    ..Among others, cysteine content is noticeable. In humans, VDAC1 has 2, VDAC2 has 9 and VDAC3 has 6 cysteines...