Gene Symbol: VDAC1
Description: voltage dependent anion channel 1
Alias: PORIN, VDAC-1, voltage-dependent anion-selective channel protein 1, outer mitochondrial membrane protein porin 1, plasmalemmal porin, porin 31HL, porin 31HM, sperm binding protein 1a
Species: human
Products:     VDAC1

Top Publications

  1. Narita M, Shimizu S, Ito T, Chittenden T, Lutz R, Matsuda H, et al. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A. 1998;95:14681-6 pubmed
    ..Taken together, these findings suggest that proapoptotic Bcl-2 family proteins, including Bax and Bak, induce the mitochondrial PT and cytochrome c release by interacting with the PT pores. ..
  2. De Stefani D, Bononi A, Romagnoli A, Messina A, De Pinto V, Pinton P, et al. VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria. Cell Death Differ. 2012;19:267-73 pubmed publisher
    ..We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect...
  3. Blachly Dyson E, Zambronicz E, Yu W, Adams V, McCabe E, Adelman J, et al. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. J Biol Chem. 1993;268:1835-41 pubmed
    ..The expression of each human cDNA has been assessed by Northern blot and polymerase chain reaction techniques. With one exception, each is expressed in all human cell lines and tissues examined. ..
  4. Crompton M, Virji S, Ward J. Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem. 1998;258:729-35 pubmed
    ..band on SDS/PAGE resolved into a doublet and reacted with antibodies against the voltage-dependent anion channel (porin) and the adenine nucleotide translocase...
  5. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999;399:483-7 pubmed
    ..In agreement with this, VDAC1-deficient mitochondria from a mutant yeast did not exhibit a Bax/Bak-induced loss in membrane potential and ..
  6. Jacotot E, Ravagnan L, Loeffler M, Ferri K, Vieira H, Zamzami N, et al. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med. 2000;191:33-46 pubmed
    ..Hence, Vpr induces apoptosis via a direct effect on the mitochondrial PTPC. ..
  7. Shimizu S, Tsujimoto Y. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci U S A. 2000;97:577-82 pubmed
    ..These findings indicated the involvement of a different mechanism in BH3-only, protein-induced apoptogenic cytochrome c release. ..
  8. Shimizu S, Konishi A, Kodama T, Tsujimoto Y. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A. 2000;97:3100-5 pubmed
    ..Finally, the data suggest that the TAT-BH4 peptide is potentially useful as a therapeutic agent for diseases caused by accelerated apoptosis. ..
  9. Massari P, Ho Y, Wetzler L. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc Natl Acad Sci U S A. 2000;97:9070-5 pubmed
    Neisserial porins are strong immune adjuvants and B cell activators. The effect of neisserial porin PorB on activation-induced cell death was investigated, as a potential additional mechanism of the porin's immunopotentiating ability...

More Information

Publications107 found, 100 shown here

  1. Jacotot E, Ferri K, El Hamel C, Brenner C, Druillennec S, Hoebeke J, et al. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. J Exp Med. 2001;193:509-19 pubmed
    ..Concomitantly, Bcl-2 suppresses channel formation by the ANT-Vpr complex in synthetic membranes. In conclusion, both Vpr and Bcl-2 modulate MMP through a direct interaction with ANT. ..
  2. Schwarzer C, Barnikol Watanabe S, Thinnes F, Hilschmann N. Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74. Int J Biochem Cell Biol. 2002;34:1059-70 pubmed
    The voltage-dependent anion-selective channel 1 (VDAC1), i.e. eukaryotic porin, functions as a channel in membranous structures as described for the outer mitochondrial membrane, the cell membrane, endosomes, caveolae, the sarcoplasmatic ..
  3. Weng C, Li Y, Xu D, Shi Y, Tang H. Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J Biol Chem. 2005;280:10491-500 pubmed
    ..These results suggested that removal of N-terminal domains of Bid by caspase-8 and Mcl-1 by caspase-3 enabled the maximal mitochondrial perturbation that potentiated TRAIL-induced apoptosis. ..
  4. Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, et al. Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A. 2008;105:15370-5 pubmed publisher
    ..Here, we present the 3D structure of human VDAC1, which was solved conjointly by NMR spectroscopy and x-ray crystallography...
  5. Tomasello F, Messina A, Lartigue L, Schembri L, Medina C, Reina S, et al. Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis. Cell Res. 2009;19:1363-76 pubmed publisher
    ..Working at the single live cell level, we found that overexpression of VDAC1 triggers MPT at the mitochondrial inner membrane (MIM)...
  6. Geisler S, Holmström K, Skujat D, Fiesel F, Rothfuss O, Kahle P, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 2010;12:119-31 pubmed publisher
    ..Strikingly, we identified VDAC1 (voltage-dependent anion channel 1) as a target for Parkin-mediated Lys 27 poly-ubiquitylation and mitophagy...
  7. Reina S, Palermo V, Guarnera A, Guarino F, Messina A, Mazzoni C, et al. Swapping of the N-terminus of VDAC1 with VDAC3 restores full activity of the channel and confers anti-aging features to the cell. FEBS Lett. 2010;584:2837-44 pubmed publisher
    ..isoform is the least abundant and least active in a complementation assay performed in a yeast strain devoid of porin-1. We swapped the VDAC3 N-terminal 20 amino acids with homologous sequences from the other isoforms...
  8. Arbel N, Ben Hail D, Shoshan Barmatz V. Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein. J Biol Chem. 2012;287:23152-61 pubmed publisher
    ..We previously demonstrated the direct interaction of Bcl2 with VDAC, leading to reduced channel conductance. VDAC1-based peptides interacted with Bcl2 to prevent its antiapoptotic activity...
  9. Sun Y, Vashisht A, Tchieu J, Wohlschlegel J, Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem. 2012;287:40652-60 pubmed publisher
    ..We hypothesize that VDACs serve as mitochondrial docking sites to recruit Parkin from the cytosol to defective mitochondria. ..
  10. McEnery M, Snowman A, Trifiletti R, Snyder S. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A. 1992;89:3170-4 pubmed
    ..VDAC and ADC, outer and inner mitochondrial membrane channel proteins, respectively, together with the 18-kDa subunit, may comprise mBzR at functionally important transport sites at the junction of two mitochondrial membranes. ..
  11. Kayser H, Kratzin H, Thinnes F, Gotz H, Schmidt W, Eckart K, et al. [Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL)]. Biol Chem Hoppe Seyler. 1989;370:1265-78 pubmed
    ..structure of a human porin with the molecular mass of 31 kDa derived from the plasmalemm of B-lymphocytes (Porin 31HL). Porin 31HL is shown to be a basic, channel forming membrane protein...
  12. Shi Y, Chen J, Weng C, Chen R, Zheng Y, Chen Q, et al. Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins. Biochem Biophys Res Commun. 2003;305:989-96 pubmed
    ..both pro-apoptotic Bax and anti-apoptotic Bcl-X(L) might simultaneously contact the putative loop regions of human VDAC1, and the existence of VDAC1-Bax-Bcl-X(L) tertiary complex in vitro suggested that VDAC1 channel conformation and ..
  13. Malia T, Wagner G. NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL. Biochemistry. 2007;46:514-25 pubmed
    ..Our characterization of the VDAC/Bcl-xL complex offers initial structural insight into the role of antiapoptotic Bcl-xL in regulating apoptotic events in the mitochondrial outer membrane. ..
  14. Hiller S, Garces R, Malia T, Orekhov V, Colombini M, Wagner G. Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science. 2008;321:1206-10 pubmed publisher
    ..NMR measurements revealed the binding sites of VDAC-1 for the Bcl-2 protein Bcl-x(L), for reduced beta-nicotinamide adenine dinucleotide, and for cholesterol. Bcl-x(L) interacts with the VDAC barrel laterally at strands 17 and 18. ..
  15. Arzoine L, Zilberberg N, Ben Romano R, Shoshan Barmatz V. Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity. J Biol Chem. 2009;284:3946-55 pubmed publisher
    ..Now, we demonstrate that synthetic peptides corresponding to the VDAC1 N-terminal region and selected sequences bound specifically, in a concentration- and time-dependent manner, to ..
  16. Geula S, Ben Hail D, Shoshan Barmatz V. Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins. Biochem J. 2012;444:475-85 pubmed publisher
    Structural studies place the VDAC1 (voltage-dependent anion channel 1) N-terminal region within the channel pore. Biochemical and functional studies, however, reveal that the N-terminal domain is cytoplasmically exposed...
  17. Du X, Shen T, Wang H, Qin X, Xing D, Ye Q, et al. Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver. J Dairy Sci. 2018;101:9544-9558 pubmed publisher
    ..I to V (CO 1-V), protein levels of cytochrome c oxidase subunit IV (COX IV), voltage dependent anion channel 1 (VDAC1), peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) and nuclear respiratory factor 1 (NRF1), ..
  18. Su Y. Regulation of endothelial nitric oxide synthase activity by protein-protein interaction. Curr Pharm Des. 2014;20:3514-20 pubmed
    ..eNOS interacts with calmodulin, heat shock protein 90 (Hsp90), dynamin-2, ?-actin, tubulin, porin, high-density lipoprotein (HDL) and apolipoprotein AI (ApoAI), resulting in increases in eNOS activity...
  19. Campos A, Araujo P, Pinheiro C, Azevedo J, Osorio H, Vasconcelos V. Effects on growth, antioxidant enzyme activity and levels of extracellular proteins in the green alga Chlorella vulgaris exposed to crude cyanobacterial extracts and pure microcystin and cylindrospermopsin. Ecotoxicol Environ Saf. 2013;94:45-53 pubmed publisher
    ..Moreover the identification of F-ATPase subunit, adenylate cyclase, sulfate ABC transporter, putative porin, aspartate aminotransferase, methylene-tetrahydrofolate dehydrogenase and chlorophyll a binding proteins in the ..
  20. Wang X, Wang L, Sun Y, Li R, Deng J, Deng J. DNA methylation and histone deacetylation regulating insulin sensitivity due to chronic cold exposure. Cryobiology. 2017;74:36-42 pubmed publisher
    ..receptor substrate 2 (IRS2), Obese receptor (Ob-R, a leptin receptor), voltage-dependent anion channel protein 1 (VDAC1), cytochrome C (cytC), 5-methylcytosine (5-mC) positive cells in hippocampal CA1 area...
  21. Zhou H, Hu S, Jin Q, Shi C, Zhang Y, Zhu P, et al. Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening. J Am Heart Assoc. 2017;6: pubmed publisher
  22. Chiu N, Huang L, Willemsen A, Bhusal C, Arora A, Reynoso Mojares Z, et al. Safety and immunogenicity of a meningococcal B recombinant vaccine when administered with routine vaccines to healthy infants in Taiwan: A phase 3, open-label, randomized study. Hum Vaccin Immunother. 2018;14:1075-1083 pubmed publisher
    ..Immune responses to 4CMenB components (factor H binding protein [fHbp], Neisserial adhesin A [NadA], porin A [PorA] and Neisseria heparin-binding antigen [NHBA]) were evaluated at 1 month post-primary and post-booster ..
  23. Li W, Wang G, Zhang S, Fu Y, Jiang Y, Yang X, et al. An integrated quantitative proteomic and metabolomics approach to reveal the negative regulation mechanism of LamB in antibiotics resistance. J Proteomics. 2019;194:148-159 pubmed publisher
    Previously, a maltose-specific channel porin, LamB was found to be associate with multi-drug resistance in a lamB deleted strain, but the exact mechanisms require further elucidation...
  24. Liu F, Tang X, Sheng X, Xing J, Zhan W. Construction and evaluation of an Edwardsiella tarda DNA vaccine encoding outer membrane protein C. Microb Pathog. 2017;104:238-247 pubmed publisher
    Outer membrane protein C is a porin that resides in the outer membrane, and it has been identified as an antigenic protein in many bacteria, such as Escherichia coli, Salmonella typhi, Aeromonas hydrophila and Edwardsiella tarda...
  25. Gaston T, Szaflarski J. Cannabis for the Treatment of Epilepsy: an Update. Curr Neurol Neurosci Rep. 2018;18:73 pubmed publisher
    ..channels, modulation of adenosine receptors, modulation of voltage-dependent anion selective channel protein (VDAC1), and modulation of tumor necrosis factor alpha release...
  26. Schager A, Dominguez Medina C, Necchi F, Micoli F, Goh Y, Goodall M, et al. IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates. MBio. 2018;9: pubmed publisher
    ..Unexpectedly, immunization with O-Ag-deficient STmGMMA did not substantially enhance the anti-porin response...
  27. Lee S, Davey L. Disulfide Bonds: A Key Modification in Bacterial Extracytoplasmic Proteins. J Dent Res. 2017;96:1465-1473 pubmed publisher
    ..such as Porphyromonas gingivalis and Tannerella forsythia, use disulfide bonds to stabilize their outer membrane porin proteins...
  28. Xing W, Yuan T, Xu J, Gu L, Liang P, Lu H. Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model. Environ Toxicol Pharmacol. 2015;40:592-9 pubmed publisher
    ..voltage-dependent anion-selective channel protein 2 (VDAC2), voltage-dependent anion-selective channel protein 1 (VDAC1), adenylate kinase 2 (KAD2) and others...
  29. Ben Hail D, Shoshan Barmatz V. VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis. Biochim Biophys Acta. 2016;1863:1612-23 pubmed publisher
    ..The voltage-dependent anion channel 1 (VDAC1), an OMM protein, is central to mitochondria-mediated apoptosis...
  30. Baghel M, Thakur M. Differential proteome profiling in the hippocampus of amnesic mice. Hippocampus. 2017;27:845-859 pubmed publisher
    ..analysis revealed that majority of identified proteins exhibit common association with Actg1 cytoskeleton and Vdac1 energy transporter protein...
  31. Deniaud A, Liguori L, Blesneac I, Lenormand J, Pebay Peyroula E. Crystallization of the membrane protein hVDAC1 produced in cell-free system. Biochim Biophys Acta. 2010;1798:1540-6 pubmed publisher
    ..Although the diffraction of VDAC crystals is limited, the simplicity and the rapidity to set-up and optimize this technology are drastic advantages in comparison to other methods. ..
  32. Manczak M, Reddy P. RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity. Biochim Biophys Acta. 2013;1832:2368-78 pubmed publisher
    ..amyloid precursor protein (APP), the microtubule-associated protein Tau, and voltage-dependent anion channel 1 (VDAC1) genes are reported to be toxic to neurons affected by Alzheimer's disease (AD)...
  33. Head S, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, et al. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. Proc Natl Acad Sci U S A. 2015;112:E7276-85 pubmed publisher
    ..major target of itraconazole in endothelial cells as the mitochondrial protein voltage-dependent anion channel 1 (VDAC1), which regulates mitochondrial metabolism by controlling the passage of ions and small metabolites through the ..
  34. Pagès J, Peslier S, Keating T, Lavigne J, Nichols W. Role of the Outer Membrane and Porins in Susceptibility of β-Lactamase-Producing Enterobacteriaceae to Ceftazidime-Avibactam. Antimicrob Agents Chemother. 2015;60:1349-59 pubmed publisher
    ..clinical isolates of the three species of Enterobacteriaceae studied were ≤ 8 mg/liter, regardless of outer membrane permeability changes resulting from an absence of defined porin proteins or upregulation of efflux.
  35. Chaudhuri A, Choi D, Kabaria S, Tran A, Junn E. MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression. J Biol Chem. 2016;291:6483-93 pubmed publisher
    ..mitochondrial proteins identified by gene ontology analysis, the expression of voltage-dependent anion channel 1 (VDAC1), a constituent of the mitochondrial permeability transition pore, was down-regulated by miR-7 through targeting 3'..
  36. Sun Q, Ba Z, Wu G, Wang W, Lin S, Yang H. Insertion sequence ISRP10 inactivation of the oprD gene in imipenem-resistant Pseudomonas aeruginosa clinical isolates. Int J Antimicrob Agents. 2016;47:375-9 pubmed publisher
    ..Sequence analysis revealed that 31 of the isolates had an insertion sequence element ISRP10 disrupting the porin gene oprD, demonstrating that ISRP10 inactivation of oprD conferred imipenem resistance in the majority of the ..
  37. Ficarra F, Grandellis C, Galván E, Ielpi L, Feil R, Lunn J, et al. Xanthomonas citri ssp. citri requires the outer membrane porin OprB for maximal virulence and biofilm formation. Mol Plant Pathol. 2017;18:720-733 pubmed publisher
    ..Our results demonstrate the importance of environmental nutrient supply and glucose uptake via OprB for Xcc virulence...
  38. Dalmolin T, Bianchini B, Rossi G, Ramos A, Gales A, Trindade P, et al. Detection and analysis of different interactions between resistance mechanisms and carbapenems in clinical isolates of Klebsiella pneumoniae. Braz J Microbiol. 2017;48:493-498 pubmed publisher
    ..carbapenemase detection, testing for the presence of efflux pump by broth microdilution and loss of porin by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Genetic similarity was evaluated by ERIC-PCR...
  39. Wang X, Yang T, Lin B, Tang Y. Effects of salinity on the performance, microbial community, and functional proteins in an aerobic granular sludge system. Chemosphere. 2017;184:1241-1249 pubmed publisher
    ..condition, 14 of 25 different protein spots were identified successfully by metaproteomic analysis, including porin, periplasmic-binding protein, and ATP-binding cassette-type for phosphonate transporter, which were expressed ..
  40. Omata T, Gohta S, Takahashi Y, Harano Y, Maeda S. Involvement of a CbbR homolog in low CO2-induced activation of the bicarbonate transporter operon in cyanobacteria. J Bacteriol. 2001;183:1891-8 pubmed
    ..strain PCC 6803, the slr0040, slr0041, slr0043, and slr0044 genes, forming an operon with a putative porin gene (slr0042), were identified as the cmpA, cmpB, cmpC, and cmpD genes, respectively, on the basis of their ..
  41. Schlattner U, Dolder M, Wallimann T, Tokarska Schlattner M. Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium. J Biol Chem. 2001;276:48027-30 pubmed
    Mitochondrial creatine kinase (MtCK) co-localizes with mitochondrial porin (voltage-dependent anion channel) and adenine nucleotide translocator in mitochondrial contact sites...
  42. Koren I, Raviv Z, Shoshan Barmatz V. Downregulation of voltage-dependent anion channel-1 expression by RNA interference prevents cancer cell growth in vivo. Cancer Biol Ther. 2010;9:1046-52 pubmed
    The voltage-dependent anion channel 1 (VDAC1), located at the outer mitochondrial membrane (OMM), is a key protein in regulating the exchange of ions, nucleotides and a variety of metabolites in and out of the mitochondria...
  43. Ganguly B, Tewari K, Singh R. Homology modeling, functional annotation and comparative genomics of outer membrane protein H of Pasteurella multocida. J Theor Biol. 2015;386:18-24 pubmed publisher
    ..From our results, OmpH of P. multocida could be classified as a homotrimeric, 16 stranded, β-barrel porin involved in the non-specific transport of small, hydrophilic molecules, serving essential osmoregulatory function...
  44. Zhang D, Yip Y, Li L. In silico construction of HK2-VDAC1 complex and investigating the HK2 binding-induced molecular gating mechanism of VDAC1. Mitochondrion. 2016;30:222-8 pubmed publisher
    Hexokinase 2 (HK2) binds to Voltage-Dependent Anion Channel 1 (VDAC1) on mitochondrial outer membrane (MOM) to facilitate a preferential access of ATP to HK2 for glycolysis, in order to maintain a constant energy source for cell ..
  45. Alves A, Costa N, Tien M, Louro R, Paquete C. Modulation of the reactivity of multiheme cytochromes by site-directed mutagenesis: moving towards the optimization of microbial electrochemical technologies. J Biol Inorg Chem. 2017;22:87-97 pubmed publisher
    ..The small tetraheme cytochrome is responsible for the delivery of electrons to the porin-cytochrome supercomplexes that permeate the outer-membrane and reduce metallic minerals or electrodes...
  46. Kliza K, Taumer C, Pinzuti I, Franz Wachtel M, Kunzelmann S, Stieglitz B, et al. Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nat Methods. 2017;14:504-512 pubmed publisher
    ..We demonstrated that linear polyubiquitination of the novel LUBAC substrate TRAF6 is essential for NF?B signaling. ..
  47. Bobba A, Casalino E, Amadoro G, Petragallo V, Atlante A. AMPK is activated early in cerebellar granule cells undergoing apoptosis and influences VADC1 phosphorylation status and activity. Apoptosis. 2017;22:1069-1078 pubmed publisher
    ..Voltage-dependent anion channel-1 (VDAC1) protein, changing from the closed inactive state to the active open state, is central to the switch between the ..
  48. Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed publisher
    ..In addition to the chemical mitophagy inducer, overexpression of voltage-dependent anion channel 1 (VDAC1) induced Parkin translocation to mitochondria, presumably by stimulating ROS generation...
  49. Díez Aguilar M, Conejo M, Morosini M, Tormo Palop N, Gimeno C, Canton R, et al. Susceptibility testing and detection of ?-lactam resistance mechanisms in Enterobacteriaceae: a multicentre national proficiency study. Int J Antimicrob Agents. 2018;51:612-619 pubmed publisher
    ..Strains with permeability deficiencies [CCS07 (ACT-1 plus porin deficit) and CCS12 (TEM-24 plus porin deficit)] were correctly detected in 17% and 10% of centres, respectively...
  50. Reimann S, Wolfe A. A critical process controlled by MalT and OmpR is revealed through synthetic lethality. J Bacteriol. 2009;191:5320-4 pubmed publisher
    ..Here we report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
  51. Okatsu K, Iemura S, Koyano F, Go E, Kimura M, Natsume T, et al. Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase. Biochem Biophys Res Commun. 2012;428:197-202 pubmed publisher
    ..Moreover, most disease-relevant mutations of Parkin hinder this event and endogenous HKI is ubiquitylated upon dissipation of mitochondrial membrane potential in genuine-Parkin expressing cells, suggesting its physiological importance. ..
  52. Li Q, Zhang L, Wan H, Liu M, Li X, Tang H. CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. Oncotarget. 2015;6:34924-40 pubmed publisher
    ..enhanced mitophagy by downregulating the mitophagy-associated protein voltage-dependent anion channel 1 (VDAC1) and by inducing the expression of miR-320a and the transcription factor cAMP responsive element binding protein 1(..
  53. Patel D, Re S, Wu E, Qi Y, Klebba P, Widmalm G, et al. Dynamics and Interactions of OmpF and LPS: Influence on Pore Accessibility and Ion Permeability. Biophys J. 2016;110:930-8 pubmed publisher
    ..Outer membrane protein F (OmpF) is a trimeric porin responsible for the passive transport of small molecules across the outer membrane of Escherichia coli...
  54. Li D, Zheng J, Wang M, Feng L, Ren Z, Liu Y, et al. Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice. Psychiatry Res. 2016;245:141-147 pubmed publisher
    ..Results showed that TSPO and other mitophagy related proteins, such as VDAC1, Pink1 and Beclin1 were significantly decreased by LH challenge...
  55. Ducret V, Gonzalez M, Scrignari T, Perron K. OprD Repression upon Metal Treatment Requires the RNA Chaperone Hfq in Pseudomonas aeruginosa. Genes (Basel). 2016;7: pubmed
    The metal-specific CzcRS two-component system in Pseudomonas aeruginosa is involved in the repression of the OprD porin, causing in turn carbapenem antibiotic resistance in the presence of high zinc concentration...
  56. Wong M, Chan E, Chen S. Isolation of carbapenem-resistant Pseudomonas spp. from food. J Glob Antimicrob Resist. 2015;3:109-114 pubmed publisher
    ..was found to be mediated by efflux systems only, whereas overexpression of MexAB-OprM efflux pump and lack of OprD porin were responsible for carbapenem resistance in P. aeruginosa...
  57. Lopes Rodrigues M, Triguero J, Torras J, Perpète E, Michaux C, Zanuy D, et al. Influence of the surrounding environment in re-naturalized β-barrel membrane proteins. Biophys Chem. 2018;234:6-15 pubmed publisher
    ..of these protein-integrated devices has been found to be strongly influenced by the instability of the β-barrel porin structure, which depends on surrounding environment...
  58. Jahan M, Tobe R, Mihara H. Characterization of a Novel Porin-Like Protein, ExtI, from Geobacter sulfurreducens and Its Implication in the Reduction of Selenite and Tellurite. Int J Mol Sci. 2018;19: pubmed publisher
    The extI gene in Geobacter sulfurreducens encodes a putative outer membrane channel porin, which resides within a cluster of extHIJKLMNOPQS genes...
  59. Shimada H, Hirai K, Simamura E, Hatta T, Iwakiri H, Mizuki K, et al. Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase. J Biol Chem. 2009;284:28642-9 pubmed publisher
    ..we demonstrated that mitochondrial NADH-dependent PQ reductase containing a voltage-dependent anion channel 1 (VDAC1) is responsible for PQ cytotoxicity...
  60. Parray H, Yun J. Proteomic Identification of Target Proteins of Thiodigalactoside in White Adipose Tissue from Diet-Induced Obese Rats. Int J Mol Sci. 2015;16:14441-63 pubmed publisher
    ..findings of this study was significant changes in Carbonic anhydrase 3 (CA3), Voltage-dependent anion channel 1 (VDAC1), phosphatidylethanolamine-binding protein 1 (PEBP1), annexin A2 (ANXA2) and lactate dehydrogenase A chain (LDHA) ..
  61. Miller S. Antibiotic Resistance and Regulation of the Gram-Negative Bacterial Outer Membrane Barrier by Host Innate Immune Molecules. MBio. 2016;7: pubmed publisher
    ..radicals, such as those found in host tissues, regulate outer membrane permeability by altering the outer membrane porin protein channels to regulate the influx of oxygen radicals as well as ?-lactam antibiotics...
  62. Meins T, Vonrhein C, Zeth K. Crystallization and preliminary X-ray crystallographic studies of human voltage-dependent anion channel isoform I (HVDAC1). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:651-5 pubmed publisher
    ..5 A resolution. The crystal lattice belongs to the trigonal space group P321, with unit-cell parameters a = 78.9, c = 165.7 A and one monomer in the asymmetric unit. ..
  63. Shoshan Barmatz V, Zakar M, Rosenthal K, Abu Hamad S. Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase. Biochim Biophys Acta. 2009;1787:421-30 pubmed publisher
    ..Here, we demonstrate that the HK-VDAC1 interaction can be disrupted by mutating VDAC1 and by VDAC1-based peptides, consequently leading to diminished HK ..
  64. Zachariae U, Schneider R, Briones R, Gattin Z, Demers J, Giller K, et al. ?-Barrel mobility underlies closure of the voltage-dependent anion channel. Structure. 2012;20:1540-9 pubmed publisher
    ..These data suggest that the N-terminal helix controls entry into elliptic ?-barrel states which underlie VDAC closure. Our results also indicate that ?-barrel channels are intrinsically flexible. ..
  65. Shoshan Barmatz V, Ben Hail D, Admoni L, Krelin Y, Tripathi S. The mitochondrial voltage-dependent anion channel 1 in tumor cells. Biochim Biophys Acta. 2015;1848:2547-75 pubmed publisher
    b>VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and efflux of metabolites, ions, nucleotides, Ca2+ and more...
  66. Saxena R, Gupta S, Singh K, Mitra K, Tripathi A, Tripathi R. Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants. PLoS ONE. 2015;10:e0122994 pubmed publisher
    ..Proteins were identified as Cyclophilin A, EIF5A-1 isoform B, Rho GDI 1 isoform a, VDAC1, OTUB1 and α-enolase isoform 1 (ENO1) through LC-MS/MS...
  67. Ham S, Lee S, Song S, Chung J, Choi S, Chung J. Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity. J Biol Chem. 2016;291:1803-16 pubmed publisher
    ..on phosphorylation at Ser-65, and interaction between the R1 domain and a mitochondrial outer membrane protein, VDAC1, are suppressed by binding of the UBL domain to the R1 domain...
  68. Budelier M, Cheng W, Bergdoll L, Chen Z, Janetka J, Abramson J, et al. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. J Biol Chem. 2017;292:9294-9304 pubmed publisher
    Voltage-dependent anion channel-1 (VDAC1) is a highly regulated ?-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell...
  69. Sirago G, Conte E, Fracasso F, Cormio A, Fehrentz J, Martinez J, et al. Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia. Sci Rep. 2017;7:13017 pubmed publisher
    ..treatment caused a decrease in mitochondrial biogenesis (PGC-1?, NRF-1, TFAM, mtDNA, ND1), mitochondrial mass (Porin and Citrate synthase activity) and fusion index (MFN2, Drp1), together with changes in the expression of autophagy-..
  70. Mans R, Hassing E, Wijsman M, Giezekamp A, Pronk J, Daran J, et al. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. FEMS Yeast Res. 2017;: pubmed publisher
    ..strain was constructed with deletions in 25 genes encoding transport proteins, including the complete aqua(glycero)porin family and all known carboxylic-acid transporters...
  71. Stadtmüller U, Eben Brunnen J, Schmid A, Hesse D, Klebert S, Kratzin H, et al. Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation. Biol Chem. 1999;380:1461-6 pubmed
    ..correspondingly, its electrophysiological characteristics in a reconstituted system were identical to those of 'Porin 31HL', the human type-1 porin purified from a crude membrane preparation of the same cell line using a different ..
  72. Vyssokikh M, Zorova L, Zorov D, Heimlich G, Jürgensmeier J, Brdiczka D. Bax releases cytochrome c preferentially from a complex between porin and adenine nucleotide translocator. Hexokinase activity suppresses this effect. Mol Biol Rep. 2002;29:93-6 pubmed
    ..Outer membrane porin acquires high binding affinity for hexokinase by interacting with the adenine nucleotide translocator (ANT) in the ..
  73. Abu Hamad S, Sivan S, Shoshan Barmatz V. The expression level of the voltage-dependent anion channel controls life and death of the cell. Proc Natl Acad Sci U S A. 2006;103:5787-92 pubmed
    ..In this study, the role of VDAC1 in regulating cell survival and death was investigated by silencing endogenous human (h)VDAC1 expression by using ..
  74. Abu Hamad S, Zaid H, Israelson A, Nahon E, Shoshan Barmatz V. Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. J Biol Chem. 2008;283:13482-90 pubmed publisher
    ..We have previously shown that HK-I decreases murine VDAC1 (mVDAC1) channel conductance, inhibits cytochrome c release, and protects against apoptotic cell death...
  75. Aram L, Geula S, Arbel N, Shoshan Barmatz V. VDAC1 cysteine residues: topology and function in channel activity and apoptosis. Biochem J. 2010;427:445-54 pubmed publisher
    ..Since cysteine residues are the major target for oxidation/reduction, we verified whether one or both VDAC1 cysteine residues are involved in VDAC1-mediated transport or apoptosis activities...
  76. Cui J, Yu M, Niu J, Yue Z, Xu Z. Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. Biosci Rep. 2011;31:429-37 pubmed publisher
    ..Thus, our study provides the rational for clinical trials using creatine to treat PD and supports the notion of exploiting LRRK2 as a drug target for PD. ..
  77. Thinnes F. Apoptogenic interactions of plasmalemmal type-1 VDAC and A? peptides via GxxxG motifs induce Alzheimer's disease - a basic model of apoptosis?. Wien Med Wochenschr. 2011;161:274-6 pubmed publisher
    Human type-1 porin/VDAC (voltage-dependent anion channel) carries a GxxxG motif in its N-terminal part, traversing the ?-barrel, while the Alzheimer's disease (AD) relevant amyloid peptides A?1-42 and A?1-40 show a series of ..
  78. Geula S, Naveed H, Liang J, Shoshan Barmatz V. Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem. 2012;287:2179-90 pubmed publisher
    ..Oligomeric assembly of VDAC1 was shown to be coupled to apoptosis induction, with oligomerization increasing substantially upon apoptosis ..
  79. Eddy M, Ong T, Clark L, Teijido O, van der Wel P, Garces R, et al. Lipid dynamics and protein-lipid interactions in 2D crystals formed with the β-barrel integral membrane protein VDAC1. J Am Chem Soc. 2012;134:6375-87 pubmed publisher
    ..MAS) NMR and (2)H NMR to study the structural and functional consequences of different membrane environments on VDAC1 and, conversely, the effect of VDAC1 on the structure of the lipid bilayer...
  80. Dezi M, Di Cicco A, Bassereau P, Levy D. Detergent-mediated incorporation of transmembrane proteins in giant unilamellar vesicles with controlled physiological contents. Proc Natl Acad Sci U S A. 2013;110:7276-81 pubmed publisher
    ..GUVs with FhuA, a bacterial porin, were used to follow the DNA injection by T5 phage upon binding to its transmembrane receptor...
  81. Tubbs E, Theurey P, Vial G, Bendridi N, Bravard A, Chauvin M, et al. Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance. Diabetes. 2014;63:3279-94 pubmed publisher
    ..Here we validated an approach based on in situ proximity ligation assay to detect and quantify VDAC1/IP3R1 and Grp75/IP3R1 interactions at the MAM interface...
  82. Gao Z, Shang Q, Liu Z, Deng C, Guo C. Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1. Oncotarget. 2015;6:36338-53 pubmed publisher
    ..to test the function of mitochondrial ATF2 and its connection to Bim and voltage-dependent anion channel 1 (VDAC1)...
  83. Cernicchiaro N, Ives S, Edrington T, Nagaraja T, Renter D. Efficacy of a Salmonella Siderophore Receptor Protein Vaccine on Fecal Shedding and Lymph Node Carriage of Salmonella in Commercial Feedlot Cattle. Foodborne Pathog Dis. 2016;13:517-25 pubmed publisher
    ..as a pen-level randomized complete block with two treatment groups, a Salmonella Newport siderophore receptor and porin proteins-based vaccine (VAC) and a nonvaccinated control (CON)...
  84. Ghosh A, Sinha D, Biswas R, Biswas T. Pathogen-associated porin turns IL-10 competent B-1a cells toward proinflammatory cytokine response. Immunobiology. 2016;221:1369-1373 pubmed publisher
    ..We analyzed the response of B-1a cells, the major component of the mucosal immune system to porin of Shigella dysenteriae type 1...
  85. Ranjit C, Noll K. Distension of the toga of Thermotoga maritima involves continued growth of the outer envelope as cells enter the stationary phase. FEMS Microbiol Lett. 2016;363: pubmed
    ..2-, 7.9- and 3-fold increase in the expression of toga structural protein genes ompB (porin), ompA1 and ompA2 (alpha helical, transperiplasm anchors), respectively...
  86. Utsunomia C, Hori C, Matsumoto K, Taguchi S. Investigation of the Escherichia coli membrane transporters involved in the secretion of d-lactate-based oligomers by loss-of-function screening. J Biosci Bioeng. 2017;124:635-640 pubmed publisher
    ..In particular, OmpF is likely to be the major porin involved in the spontaneous secretion of D-LAOs due to the high basal expression of ompF in the parental strain...
  87. Maurya S, Mahalakshmi R. Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities. Biol Rev Camb Philos Soc. 2017;92:1843-1858 pubmed publisher
    ..The primary role of VDACs is metabolite flux. The pro- and anti-apoptotic role of VDAC1 and VDAC2, respectively, are secondary, and are influenced by external factors and interacting proteins...
  88. Kasashima K, Ohta E, Kagawa Y, Endo H. Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2. J Biol Chem. 2006;281:36401-10 pubmed
    ..Here, we first demonstrated the roles of mammalian PHB2 in mitochondria and the molecular mechanism of its nuclear targeting and showed that PHB2 is a possible molecule directly coupling nuclear-mitochondrial interaction. ..
  89. Engelhardt H, Meins T, Poynor M, Adams V, Nussberger S, Welte W, et al. High-level expression, refolding and probing the natural fold of the human voltage-dependent anion channel isoforms I and II. J Membr Biol. 2007;216:93-105 pubmed
    ..Our analysis strongly suggests a 16-stranded, antiparallel beta-barrel with one large and seven short loops and turns. Initial crystallization trials of the protein yielded crystals diffracting to 8 Angstrom resolution. ..
  90. Galli S, Jahn O, Hitt R, Hesse D, Opitz L, Plessmann U, et al. A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells. PLoS ONE. 2009;4:e7541 pubmed publisher
    ..e. VDAC1), signalling, and metabolism; (ii) histones H2A and H4; and (iii) other cytosolic proteins...
  91. Narendra D, Kane L, Hauser D, Fearnley I, Youle R. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy. 2010;6:1090-106 pubmed
    ..Although VDAC1 (but not VDAC2) is ubiquitinated following mitochondrial depolarization, we find VDAC1 cannot fully account for ..
  92. Brahimi Horn M, Lacas Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, et al. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015;35:1491-505 pubmed publisher
    ..These novel findings provide the framework for a better understanding of hypoxic cell metabolism and cell survival through mitochondrial-endolysosomal microfusion regulated by hypoxia-inducible factor 1 and TP53. ..