Gene Symbol: VCAM-1
Description: vascular cell adhesion molecule 1
Alias: CD106, INCAM-100, vascular cell adhesion protein 1, CD106 antigen
Species: human
Products:     VCAM-1

Top Publications

  1. Deem T, Cook Mills J. Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species. Blood. 2004;104:2385-93 pubmed
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration. ..
  2. Stins M, Shen Y, Huang S, Gilles F, Kalra V, Kim K. Gp120 activates children's brain endothelial cells via CD4. J Neurovirol. 2001;7:125-34 pubmed
    ..Gp120-induced monocyte migration was inhibited by anti-gp120 and anti-CD4 antibodies. This is the first demonstration that gp120 activates HBMEC via CD4, which may contribute to the development of HIV-1 encephalopathy in children. ..
  3. Lee S, Kim J, Yang W, Kim S, Park S, Park J. Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells. Role of cyclic GMP and NF-kappaB. Nephron. 2002;90:447-54 pubmed
    ..These results suggest that exogenous NO inhibits VCAM-1 expression via suppression of NF-kappaB through a cGMP-independent pathway. ..
  4. Woodside D, Kram R, Mitchell J, Belsom T, Billard M, McIntyre B, et al. Contrasting roles for domain 4 of VCAM-1 in the regulation of cell adhesion and soluble VCAM-1 binding to integrin alpha4beta1. J Immunol. 2006;176:5041-9 pubmed
    ..These results indicate that the domain 4 of VCAM-1 plays a contrasting role when VCAM-1 is presented in solution or as a cell surface-expressed adhesive substrate. ..
  5. Fitau J, Boulday G, Coulon F, Quillard T, Charreau B. The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways. J Biol Chem. 2006;281:20148-59 pubmed
    ..Collectively, our results identify the adaptor Lnk as a negative regulator in the TNFalpha-signaling pathway mediating ERK inhibition and suggest a role for Lnk in the interplay between PI3K and ERK triggered by TNFalpha in ECs. ..
  6. Harris T, Yamakuchi M, Ferlito M, Mendell J, Lowenstein C. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A. 2008;105:1516-21 pubmed publisher
    ..These data suggest that microRNA can regulate adhesion molecule expression and may provide additional control of vascular inflammation. ..
  7. Cybulsky M, Fries J, Williams A, Sultan P, Davis V, Gimbrone M, et al. Alternative splicing of human VCAM-1 in activated vascular endothelium. Am J Pathol. 1991;138:815-20 pubmed
    ..Alternative splicing of the VCAM-1 gene in cytokine-activated endothelium may generate functionally distinct cell-surface adhesion molecules. ..
  8. Polte T, Newman W, Raghunathan G, Gopal T. Structural and functional studies of full-length vascular cell adhesion molecule-1: internal duplication and homology to several adhesion proteins. DNA Cell Biol. 1991;10:349-57 pubmed
  9. Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj S, Chi Rosso G, et al. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989;59:1203-11 pubmed
    ..VCAM-1, which belongs to the immunoglobulin gene super-family, may be central to recruitment of mononuclear leukocytes into inflammatory sites in vivo. ..

More Information

Publications109 found, 100 shown here

  1. Chan J, Hyduk S, Cybulsky M. Alpha 4 beta 1 integrin/VCAM-1 interaction activates alpha L beta 2 integrin-mediated adhesion to ICAM-1 in human T cells. J Immunol. 2000;164:746-53 pubmed
    ..A role for the cytoskeleton is implicated in this process. ..
  2. Barreiro O, Yanez Mo M, Serrador J, Montoya M, Vicente Manzanares M, Tejedor R, et al. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J Cell Biol. 2002;157:1233-45 pubmed
    ..These results provide the first characterization of an endothelial docking structure that plays a key role in the firm adhesion of leukocytes to the endothelium during inflammation. ..
  3. Stins M, Pearce D, Di Cello F, Erdreich Epstein A, Pardo C, Sik Kim K. Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors. Lab Invest. 2003;83:1787-98 pubmed
    ..The activation of brain endothelium of children by HIV-1 protein gp120 by way of CD4 and chemokine receptors may have implications for the pathogenesis of HIV-1 encephalopathy in the pediatric population. ..
  4. Piconi L, Quagliaro L, Da Ros R, Assaloni R, Giugliano D, Esposito K, et al. Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. J Thromb Haemost. 2004;2:1453-9 pubmed
    ..Thus, PARP activation appears to be involved in both promoting nitrosative stress and upregulating adhesion molecules and inflammation in endothelial cells exposed to oscillating high glucose conditions. ..
  5. Johnson L, Clasper S, Holt A, Lalor P, Baban D, Jackson D. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203:2763-77 pubmed
    ..These results reveal a CAM-mediated mechanism for recruiting leukocytes to the lymph nodes in inflammation and highlight the process of lymphatic transmigration as a potential new target for antiinflammatory therapy. ..
  6. Klemke M, Weschenfelder T, Konstandin M, Samstag Y. High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J Cell Physiol. 2007;212:368-74 pubmed
    ..These data imply that only high affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells. ..
  7. Slack Davis J, Atkins K, Harrer C, Hershey E, Conaway M. Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. Cancer Res. 2009;69:1469-76 pubmed publisher
    ..Together, these observations implicate VCAM-1-alpha(4)beta(1) integrin interactions in the regulation of ovarian cancer cell mesothelial invasion and metastatic progression and offer the possibility of novel therapeutic targets. ..
  8. Luo S, Fang R, Hsieh H, Chi P, Lin C, Hsiao L, et al. Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2010;62:105-16 pubmed publisher
    ..To investigate the roles of MAPKs and NF-kappaB in tumor necrosis factor alpha (TNFalpha)-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human rheumatoid arthritis synovial fibroblasts (RASFs)...
  9. Gower R, Wu H, Foster G, Devaraj S, Jialal I, Ballantyne C, et al. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011;31:160-6 pubmed publisher
    ..These data suggest that analysis of monocyte inflammation may provide an additional framework for evaluating individual susceptibility to cardiovascular disease. ..
  10. Veas C, Aguilera V, Muñoz I, Gallardo V, Miguel P, González M, et al. Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia. J Matern Fetal Neonatal Med. 2011;24:1371-7 pubmed publisher
    ..5-fold) compared with women with low levels. High circulating levels of maternal endothelial dysfunction markers present in pre-eclampsia are associated with decreased NO synthesis in fetal endothelium. ..
  11. Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging ?4?1-positive osteoclast progenitors. Cancer Cell. 2011;20:701-14 pubmed publisher
    ..These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone. ..
  12. Sun C, Alkhoury K, Wang Y, Foster G, Radecke C, Tam K, et al. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal. Circ Res. 2012;111:1054-64 pubmed
    ..Subjects with an anti-inflammatory response to a meal produced TGRL that was enriched in nonesterified fatty acids, decreased IRF-1 expression, increased miR-126 activity, and diminished monocyte arrest. ..
  13. Osborn L, Vassallo C, Benjamin C. Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1. J Exp Med. 1992;176:99-107 pubmed
    ..Therefore both sites must be blocked in clinical, animal, or in vitro studies depending on the use of anti-VCAM-1 antibodies to inactivate the VCAM-1/VLA-4 adhesion pathway. ..
  14. Lazaar A, Krymskaya V, Das S. VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells. J Immunol. 2001;166:155-61 pubmed
    ..These studies suggest that VCAM-1 is linked to multiple signaling pathways in human ASM cells and may function to augment growth factor-induced responses. ..
  15. Yim J, Cho H, Rabkin S. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clin Exp Hypertens. 2017;:1-12 pubmed publisher
  16. Teixeira T, da Costa D, Resende A, Soulage C, Bezerra F, Daleprane J. Activation of Nrf2-Antioxidant Signaling by 1,25-Dihydroxycholecalciferol Prevents Leptin-Induced Oxidative Stress and Inflammation in Human Endothelial Cells. J Nutr. 2017;147:506-513 pubmed publisher
    ..b>Conclusion: Pretreatment with 1,25(OH)2D3 in the presence of a high concentration of leptin has a beneficial effect on HUVECs through the regulation of mediators of antioxidant activity and inflammation. ..
  17. Sahraoui A, Dewachter C, de Medina G, Naeije R, Aouichat Bouguerra S, Dewachter L. Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils. PLoS ONE. 2016;11:e0148117 pubmed publisher
  18. Rom S, Zuluaga Ramirez V, Reichenbach N, Erickson M, Winfield M, Gajghate S, et al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018;15:25 pubmed publisher
    ..SDG can serve as an anti-inflammatory and barrier-protective agent in neuroinflammation. ..
  19. Baghdasaryan A, Fuchs C, Österreicher C, Lemberger U, Halilbasic E, Påhlman I, et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis. J Hepatol. 2016;64:674-81 pubmed publisher
    ..Pharmacological ASBT inhibition attenuates cholestatic liver and bile duct injury by reducing biliary BA concentrations in mice. ..
  20. Alghamdi T, Batchu S, Hadden M, Yerra V, Liu Y, Bowskill B, et al. Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease. Diabetes. 2018;67:2668-2681 pubmed publisher
    ..Culture media conditioned by podocytes exposed to high glucose caused glomerular endothelial vascular cell adhesion protein 1 (VCAM-1) upregulation and was enriched for the chemokine CCL2...
  21. Vastrad B, Vastrad C, Tengli A, Iliger S. Identification of differentially expressed genes regulated by molecular signature in breast cancer-associated fibroblasts by bioinformatics analysis. Arch Gynecol Obstet. 2018;297:161-183 pubmed publisher
  22. Lozhkin A, Vendrov A, Pan H, Wickline S, Madamanchi N, Runge M. NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis. J Mol Cell Cardiol. 2017;102:10-21 pubmed publisher
    ..Together, these data demonstrate that increased expression and activation of NOX4, which might result from increased TGFβ1 levels seen during aging, induces a proinflammatory phenotype in VSMCs, enhancing atherosclerosis. ..
  23. Jaeger A, Bardehle D, Oster M, Günther J, Muráni E, Ponsuksili S, et al. Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro. Vet Res. 2015;46:50 pubmed publisher
    ..The results indicate that the course of PDS depends on the host recognition of different structural and pathogenic profiles first, which critically determines the extent and effectiveness of cellular immune defense after infection. ..
  24. Petersheim D, Massaad M, Lee S, Scarselli A, Cancrini C, Moriya K, et al. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2018;141:1060-1073.e3 pubmed publisher
    ..IκBα point mutants accumulate at higher levels compared with truncation mutants and are associated with more severe disease and greater impairment of canonical and noncanonical NF-κB activity in patients with AD EDA-ID. ..
  25. Kowalewska P, Patrick A, Fox Robichaud A. Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. PLoS ONE. 2014;9:e104537 pubmed publisher
    ..Antibody blockade of β2 integrin (CD18), ICAM-1 (CD54) and VCAM-1 (CD106) did not decrease leukocyte adhesion in response to LTA challenge while blockade of P-selectin (CD62P) abrogated ..
  26. Wu X, Ouyang Z, Feng L, Chen G, Guo W, Shen Y, et al. Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone. Toxicol Appl Pharmacol. 2014;281:146-56 pubmed publisher
    ..Overall, our results support fraxinellone as a novel drug candidate in the treatment of colonic inflammation. ..
  27. Hilden T, Valmu L, Kärkkäinen S, Gahmberg C. Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides. J Immunol. 2003;170:4170-7 pubmed
    ..Sequence analysis by manual radiosequencing by Edman degradation established that threonine phosphorylation occurred in the same threonine triplet as in beta(2) phosphorylation. ..
  28. Benítez M, Cuniberti L, Fornari M, Gomez Rosso L, Berardi V, Elikir G, et al. Endothelial and leukocyte adhesion molecules in primary hypertriglyceridemia. Atherosclerosis. 2008;197:679-87 pubmed
    ..The increase in circulating and leukocyte cell adhesion molecules in primary hypertriglyceridemic patients would highlight the inflammatory process which is a key event in atherogenesis. ..
  29. Martin Antonio B, Carmona M, Falantes J, Gil E, Baez A, Suarez M, et al. Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34+ cell collection yield after administration of granulocyte colony-stimulating factor to healthy donors. Haematologica. 2011;96:102-9 pubmed publisher
    ..3 versus 6.7; P = 0.02 and 399 versus 533; P = 0.01, respectively). Conclusions In conclusion, genetic variability in molecules involved in migration and homing of CD34(+) cells influences the degree of mobilization of these cells. ..
  30. Schlesinger M, Bendas G. Vascular cell adhesion molecule-1 (VCAM-1)--an increasing insight into its role in tumorigenicity and metastasis. Int J Cancer. 2015;136:2504-14 pubmed publisher
    ..By illustrating the intriguing role of VCAM-1 in cancer disease, VCAM-1 is suggested as a new and up to now underestimated target in cancer treatment and in clinical diagnosis of malignancies. ..
  31. Elsaesser A, Schwarz S, Joos H, Koerber L, Brenner R, Rotter N. Characterization of a migrative subpopulation of adult human nasoseptal chondrocytes with progenitor cell features and their potential for in vivo cartilage regeneration strategies. Cell Biosci. 2016;6:11 pubmed publisher
    ..Significant differences were found for CD9, CD29, CD44, CD90, CD105 and CD106. The cells possessed a high migratory ability in a Boyden chamber assay and responded to chemotactic stimulation...
  32. Klings E, Anton Bland D, Rosenman D, Princeton S, Odhiambo A, Li G, et al. Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression. Am J Hematol. 2008;83:547-53 pubmed publisher
  33. De Cicco C, Ravasi L, Zorzino L, Sandri M, Botteri E, Verweij F, et al. Circulating levels of VCAM and MMP-2 may help identify patients with more aggressive prostate cancer. Curr Cancer Drug Targets. 2008;8:199-206 pubmed
    ..The scientific community should further investigate impact on prognosis of VCAM and MMP-2. ..
  34. Sampaio M, Vettore A, Yamamoto M, Chauffaille M, Zago M, Colleoni G. Expression of eight genes of nuclear factor-kappa B pathway in multiple myeloma using bone marrow aspirates obtained at diagnosis. Histol Histopathol. 2009;24:991-7 pubmed publisher
    ..Also, ICAM1 was overexpressed in 26% of cases and its level was associated with ISS scores. ..
  35. Lee J, Chen H, Pullikotil P, Quon M. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA. J Biol Chem. 2011;286:6423-32 pubmed publisher
    ..We conclude that FoxO1 is a novel physiological substrate for PKA-? in vascular endothelial cells. ..
  36. Tuzcu Z, Asicioglu E, Sunbul M, Ozben B, Arikan H, Koc M. Circulating endothelial cell number and markers of endothelial dysfunction in previously preeclamptic women. Am J Obstet Gynecol. 2015;213:533.e1-7 pubmed publisher
    ..However, sVEGFR-1 levels remain higher in women with a history of preeclampsia compared with women without a history of preeclampsia. ..
  37. Wan J, Wen D, Dong L, Tang J, Liu D, Liu Y, et al. Establishment of monoclonal HCC cell lines with organ site-specific tropisms. BMC Cancer. 2015;15:678 pubmed publisher
  38. Macanas Pirard P, Quezada T, Navarrete L, Broekhuizen R, Leisewitz A, Nervi B, et al. The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells. PLoS ONE. 2017;12:e0168888 pubmed publisher
    ..In conclusion, CCL2/CCR2 axis is expressed in the majority of monocytoid AML blasts. The axis is involved in cell trafficking and proliferation but no in vitro and in vivo chemotherapy protective effect was seen. ..
  39. Kelsh Lasher R, Ambesi A, Bertram C, McKeown Longo P. Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain. J Invest Dermatol. 2017;137:2505-2512 pubmed publisher
    ..The data suggest a paradigm of damage-associated molecular pattern-based signaling whereby damage-associated molecular pattern binding integrins cooperate with innate immune receptors to stimulate inflammation and fibrosis. ..
  40. Danahy D, Anthony S, Jensen I, Hartwig S, Shan Q, Xue H, et al. Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog. 2017;13:e1006569 pubmed publisher
    ..Thus, sepsis has the capacity to alter skin TRM anamnestic responses without directly impacting TRM number and/or function, an observation that helps to further define the immunoparalysis phase in sepsis survivors. ..
  41. Mukherjee T, Dinh H, Chaudhuri G, Nathan L. Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis. Proc Natl Acad Sci U S A. 2002;99:4055-60 pubmed
    ..Results from our study may help explain the mechanism by which testosterone may have beneficial effects on the cardiovascular system. ..
  42. Rajashekhar G, Loganath A, Roy A, Wong Y. Expression and secretion of the vascular cell adhesion molecule-1 in human placenta and its decrease in fetal growth restriction. J Soc Gynecol Investig. 2003;10:352-60 pubmed
    ..The decreased VCAM-1 expression in FGR pregnancy could be attributed to the uteroplacental deficiency that is characteristic of this condition. ..
  43. Boulbou M, Koukoulis G, Petinaki E, Germenis A, Gourgoulianis K. Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients. Acta Diabetol. 2004;41:118-22 pubmed
    ..However, a direct implication of adhesion molecules in the pathogenesis or progression of type 2 diabetic retinopathy cannot be supported. ..
  44. Parra Cordero M, Turan O, Kaur A, Pearson J, Nicolaides K. Maternal serum soluble adhesion molecule levels at 11+0-13+6 weeks and subsequent development of pre-eclampsia. J Matern Fetal Neonatal Med. 2007;20:793-6 pubmed
    ..These results suggest that there is no endothelial activation before the appearance of clinical signs of pre-eclampsia. Therefore, these biochemical markers are unlikely to become early predictors of this condition. ..
  45. Rajan S, Ye J, Bai S, Huang F, Guo Y. NF-kappaB, but not p38 MAP kinase, is required for TNF-alpha-induced expression of cell adhesion molecules in endothelial cells. J Cell Biochem. 2008;105:477-86 pubmed publisher
    ..The inhibition of SB at 10 microM on TNF-alpha-induced ICAM-1, VCAM-1 and E-selectin is likely due to the nonspecific effect of SB. ..
  46. Cartee T, White K, Newton West M, Swerlick R. Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism. J Dermatol Sci. 2012;65:86-94 pubmed publisher
    ..Identification of this dioxygenase may provide a valuable target for modulating inflammation in human tissues. ..
  47. Touvier M, Fezeu L, Ahluwalia N, Julia C, Charnaux N, Sutton A, et al. Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk. World J Gastroenterol. 2012;18:2805-12 pubmed publisher
    ..5%). These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. ..
  48. Chakraborty S, Hu S, Wu S, Karmenyan A, Chiou A. The interaction affinity between vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) analyzed by quantitative FRET. PLoS ONE. 2015;10:e0121399 pubmed publisher
  49. Youn G, Ju S, Choi S, Park J. HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes. Glia. 2015;63:1953-1965 pubmed publisher
  50. Agassandian M, Tedrow J, Sembrat J, KASS D, Zhang Y, Goncharova E, et al. VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis. Cell Signal. 2015;27:2467-73 pubmed publisher
    ..Thus, these observations suggest that VCAM-1 is a TGF-β1 responsive mediator that partakes in fibroblast proliferation in subjects with IPF. ..
  51. Fan Y, Chen J, Yang Y, Lin J, Wu Z. Genome-wide expression and methylation profiling reveal candidate genes in osteoarthritis. Clin Exp Rheumatol. 2017;35:983-990 pubmed
  52. Boyce J, Mellor E, Perkins B, Lim Y, Luscinskas F. Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002;99:2890-6 pubmed
    ..These observations may explain the abundance of MCs at sites of mucosal inflammation, where VCAM-1 and E-selectin are important inducible receptors. ..
  53. Crook M, Southgate K, Newby A. Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein. J Vasc Res. 2002;39:221-9 pubmed
    ..These experiments imply that either integrin might be targeted to reduce monocyte infiltration into HSV grafts. ..
  54. Wang Z, Yu Y, Shen L. [Relationship between pathological changes and the expression of vascular cell adhesion molecule-1 in the placenta of patients with pregnancy-induced hypertension complicated by intrauterine growth retardation]. Di Yi Jun Yi Da Xue Xue Bao. 2002;22:1022-4 pubmed
    ..05). Significant pathological changes can be present in the placenta of patients with PIH complicated by IUGR, and may be intimately related to abnormal expressions of VCAM-1 in the placenta. ..
  55. Séguin C, Abid M, Spokes K, Schoots I, Brkovic A, Sirois M, et al. Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells. Biomed Pharmacother. 2008;62:395-400 pubmed publisher
    ..Together, these findings suggest that Hcy sensitizes HUVEC to the effect of inflammatory mediators thrombin and LPS, at least in part through VCAM-1 expression and function. ..
  56. Lozano Nuevo J, Estrada Garcia T, Vargas Robles H, Escalante Acosta B, Rubio Guerra A. Correlation between circulating adhesion molecules and resistin levels in hypertensive type-2 diabetic patients. Inflamm Allergy Drug Targets. 2011;10:27-31 pubmed
    ..10, p = 0.24) concentrations. VCAM-1 and resistin may participate in the pathophysiology of vascular damage in hypertensive type-2 diabetic patients. Serum resistin concentrations may be a marker of endothelial dysfunction. ..
  57. Kłoda K. [Associations of ICAM1 gene and VCAM1 promoter polymorphisms with transplanted kidney function]. Ann Acad Med Stetin. 2011;57:65-72 pubmed
    ..There was no correlation of the rs1041163 and rs3170794 polymorphisms of the VCAM1 promoter with the severity of histopathologic lesions seen in bioptates of the grafted kidney. ..
  58. Taverna S, Fontana S, Monteleone F, Pucci M, Saieva L, De Caro V, et al. Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21. Oncotarget. 2016;7:30420-39 pubmed publisher
    ..Taken together our data indicated that also Curcumin attenuates the exosome's ability to promote the angiogenic phenotype and to modulate the endothelial barrier organization. ..
  59. Fan J, Liu D, He C, Li X, He F. Inhibiting adhesion events by Panax notoginseng saponins and Ginsenoside Rb1 protecting arteries via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway. J Ethnopharmacol. 2016;192:423-430 pubmed publisher
    ..Nrf2, an EC protective system, suppresses monocyte adhesion events via the inhibition of the ROS - TNF-? - p38 - VCAM-1 pathway following treatment with PNS, with Rb1 specifically playing an important role among PNS active components. ..
  60. Loh Y, Tan S, Kwok M, Stark M, Marks D. Reduction of biological response modifiers in the supernatant of washed paediatric red blood cells. Vox Sang. 2016;111:365-373 pubmed publisher
    ..washed RBC led to endothelial cell activation, with increased cell surface expression of CD62E (E-selectin) and CD106 (VCAM)...
  61. Wang J, Pepinsky B, Karpusas M, Liu J, Osborn L. Crystallization and preliminary crystallographic analysis of the N-terminal two domain fragment of vascular cell adhesion molecule-1 (VCAM-1). Proteins. 1994;20:287-90 pubmed
    ..4 A, b = 45.7 A, c = 54.7 A, and beta = 100.5 degrees. Diffraction data up to 1.9 A resolution have been collected for the C2 crystal form. ..
  62. Allanore Y, Borderie D, Lemarechal H, Ekindjian O, Kahan A. Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1. Arthritis Res Ther. 2004;6:R309-14 pubmed
    ..However, more experimental evidence is needed to determine whether the VEGF pathway is intrinsically defective in SSc. ..
  63. Mangan S, Van Campenhout A, Rush C, Golledge J. Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor necrosis factor-alpha associated with induction of angiopoietin-2. Cardiovasc Res. 2007;76:494-505 pubmed
    ..These findings suggest a mechanism by which OPG may stimulate inflammation in atheroma and thereby promote the progression and complications of atherosclerosis. ..
  64. Schmidt C, Hulthe J, Fagerberg B. Baseline ICAM-1 and VCAM-1 are increased in initially healthy middle-aged men who develop cardiovascular disease during 6.6 years of follow-up. Angiology. 2009;60:108-14 pubmed publisher
    ..8, 95% CI = 1.8-4.3; and OR = 1.6, 95% CI = 1.1-2.5, respectively). ..
  65. Rubio Guerra A, Vargas Robles H, Lozano Nuevo J, Escalante Acosta B. Correlation between circulating adhesion molecule levels and albuminuria in type-2 diabetic hypertensive patients. Kidney Blood Press Res. 2009;32:106-9 pubmed publisher
    ..4, p < 0.02). Our results suggest that VCAM-1 may be a marker of nephropathy in hypertensive type-2 diabetic patients. ..
  66. Abd Elkareem M, Al Tamimy H, Khamis O, Abdellatif S, Hussein M. Increased urinary levels of the leukocyte adhesion molecules ICAM-1 and VCAM-1 in human lupus nephritis with advanced renal histological changes: preliminary findings. Clin Exp Nephrol. 2010;14:548-57 pubmed publisher
    ..The hypocomplementemia combined with increased urinary levels of adhesion molecules seems to be a useful biomarker of disease severity in LN. ..
  67. Howe H, Kong K, Thong B, Law W, Chia F, Lian T, et al. Urine sVCAM-1 and sICAM-1 levels are elevated in lupus nephritis. Int J Rheum Dis. 2012;15:13-6 pubmed publisher
    ..In addition, both urine sVCAM-1 and sICAM-1 levels may be useful in identifying patients at risk of lupus nephritis. ..
  68. Liu J, Hou S, Tsai C, Huang C, Hsu C, Tang C. CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion. Biochim Biophys Acta. 2013;1833:966-75 pubmed publisher
    ..Our results suggest that CCN4 increases VCAM-1 expression in human OASFs via the Syk, PKC?, JNK, c-Jun, and AP-1 signaling pathways. The CCN4-induced VCAM-1 expression promoted monocyte adhesion to human OASFs. ..
  69. Spring F, Griffiths R, Mankelow T, Agnew C, Parsons S, Chasis J, et al. Tetraspanins CD81 and CD82 facilitate ?4?1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1. PLoS ONE. 2013;8:e62654 pubmed publisher
    ..These results strongly suggest that tetraspanins have a functional role in terminal erythropoiesis by modulating interactions of erythroblast ?4?1 with both macrophages and extracellular matrix. ..
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    ..The C allele of the rs1041163 VCAM1 gene may be associated with long-term allograft failure and graft loss, as well as increased morbidity after transplantation. ..
  71. Attia E, Jolley S, Crothers K, Schnapp L, Liles W. Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome. PLoS ONE. 2016;11:e0149687 pubmed publisher
    ..Further studies are necessary to characterize the role and/or clinical significance of sVCAM-1 and other endothelial activation markers present in the alveolar space in ARDS. ..
  72. Lefere S, van de Velde F, Devisscher L, Bekaert M, Raevens S, Verhelst X, et al. Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease. Int J Obes (Lond). 2017;41:1207-1213 pubmed publisher
    ..030). In the bariatric surgery and clinical validation cohorts, VCAM-1 displayed similar AUROCs of 0.89 and 0.85, respectively. VCAM-1 levels are able to accurately predict significant (⩾F2) fibrosis in NAFLD patients. ..
  73. Gavina M, Belicchi M, Rossi B, Ottoboni L, Colombo F, Meregalli M, et al. VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation. Blood. 2006;108:2857-66 pubmed
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    ..Furthermore, our data suggest an important potential steroid-sparing role for such drugs in the treatment of allergic inflammatory conditions. ..
  75. Vaccaro F, Mulè G, Cottone S, Soresi M, Giannitrapani L, Vadalà A, et al. Circulating levels of adhesion molecules in chronic kidney disease correlate with the stage of renal disease and with C-reactive protein. Arch Med Res. 2007;38:534-8 pubmed
    ..The clinical significance of our findings warrants further investigation. ..
  76. Jakimiuk A, Bogusiewicz M, Skorupski P, Adamiak A, Miotła P, Haczynski J, et al. Relationship between estrogen receptor-alpha polymorphism and serum levels of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, C-reactive protein and homocysteine in postmenopausal women. Gynecol Endocrinol. 2007;23:584-9 pubmed
    ..The results of our study suggest that genetic variation in ER gene may influence blood levels of VCAM-1 in women after the menopause. ..
  77. Fukiage K, Aoyama T, Shibata K, Otsuka S, Furu M, Kohno Y, et al. Expression of vascular cell adhesion molecule-1 indicates the differentiation potential of human bone marrow stromal cells. Biochem Biophys Res Commun. 2008;365:406-12 pubmed
    ..Among 13 CD antigens analyzed, only CD106/Vascular cell adhesion molecule-1 (VCAM-1) showed a clear correlation with the differentiation potential of each ..
  78. Madden L, Vince R, Sandstrom M, Taylor L, McNaughton L, Laden G. Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects. Thromb Haemost. 2008;99:909-15 pubmed publisher
    ..To our knowledge this is the first such report of quantified measurements of these MP over a 24-h period and the only measurement of a 24-h variation of in-vivo blood-borne TF. ..
  79. Gaspari T, Liu H, Welungoda I, Hu Y, Widdop R, Knudsen L, et al. A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model. Diab Vasc Dis Res. 2011;8:117-24 pubmed publisher
    ..Together these studies identify in vivo protection, by the GLP-1R agonist liraglutide, against ECD and provide a potential molecular mechanism responsible for these effects. ..
  80. Kanmaz Özer M, Dogru Abbasoglu S, Vural P, Ozderya A, Karadag B, Uysal M. ICAM1 K469E and E-selectin S128R polymorphisms could predispose to increased autoantibody production and TSH suppression in Graves' disease. Mol Biol Rep. 2013;40:2717-22 pubmed publisher
    ..Further studies with a larger cohort, analyzing other polymorphisms in ICAM, VCAM1 and E-selectin genes are necessary to support our observations. ..
  81. Huang X, He D, Ming J, He Y, Zhou C, Ren H, et al. High-density lipoprotein of patients with breast cancer complicated with type 2 diabetes mellitus promotes cancer cells adhesion to vascular endothelium via ICAM-1 and VCAM-1 upregulation. Breast Cancer Res Treat. 2016;155:441-55 pubmed publisher
    ..This work indicates a prospective utilization of HDL-based strategies in the treatment of breast cancer patients with type 2 diabetes. ..
  82. Du W, Li X, Chi Y, Ma F, Li Z, Yang S, et al. VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity. Stem Cell Res Ther. 2016;7:49 pubmed publisher
    ..Our results suggested that VCAM-1(+)CV-MSCs may represent an important subpopulation of MSC for efficient therapeutic angiogenesis. ..
  83. Toma L, Sanda G, Deleanu M, Stancu C, Sima A. Glycated LDL increase VCAM-1 expression and secretion in endothelial cells and promote monocyte adhesion through mechanisms involving endoplasmic reticulum stress. Mol Cell Biochem. 2016;417:169-79 pubmed publisher
  84. Pezzi N, Assis A, Cotrim Sousa L, Lopes G, Mosella M, Lima D, et al. Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction. Mol Immunol. 2016;77:157-73 pubmed publisher
    ..Thymocytes co-cultured with Aire KD mTECs had a significantly reduced capacity to adhere to these cells. This finding is the first direct evidence that Aire also plays a role in controlling mTEC-thymocyte adhesion. ..
  85. Lopez Vilchez I, Diaz Ricart M, Navarro V, Torramade S, Zamorano León J, Lopez Farre A, et al. Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model. Transl Psychiatry. 2016;6:e886 pubmed publisher
  86. Pollock K, Samsonraj R, Dudakovic A, Thaler R, Stumbras A, McKenna D, et al. Improved Post-Thaw Function and Epigenetic Changes in Mesenchymal Stromal Cells Cryopreserved Using Multicomponent Osmolyte Solutions. Stem Cells Dev. 2017;26:828-842 pubmed publisher
    ..regulator galanin, the antiapoptotic marker B cell lymphoma 2, as well as the cell surface adhesion molecules CD106 (vascular cell adhesion molecule 1) and CD54 (intracellular adhesion molecule 1) are all elevated in DMSO-free ..
  87. Chang L, Peng S, Chou C, Chen Y, Shiu J, Tu P, et al. Therapeutic potential of amniotic fluid stem cells to treat bilateral ovarian dystrophy in dairy cows in a subtropical region. Reprod Domest Anim. 2017;: pubmed publisher
    ..The BAFSCs began to show a fibroblast-like morphology. They were positive for ?-integrin, CD44, CD73, CD106 and Oct4 and negative for CD34 and CD45. After induction, the cells differentiated into mesodermal lineages...
  88. Andresen T, Svennevig J, Videm V. Soluble VCAM-1 is a very early marker of endothelial cell activation in cardiopulmonary bypass. Perfusion. 2002;17:15-21 pubmed
    ..The clinical significance of sVCAM-1 measurements must be further evaluated in future patient studies. ..
  89. Minami T, Abid M, Zhang J, King G, Kodama T, Aird W. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003;278:6976-84 pubmed
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways. ..
  90. Merlini P, Rossi M, Faioni E, Franchi F, Bramucci E, Lucreziotti S, et al. Expression of endothelial protein C receptor and thrombomodulin in human coronary atherosclerotic plaques. Ital Heart J. 2004;5:42-7 pubmed
    ..RNA may be extracted from ex vivo atherosclerotic plaques. In addition to anticoagulation, endothelial protein C receptor may play an important inflammation-related role in plaque development. ..
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    ..However, these results should be interpreted with caution due to the potential for false positive results that can arise from analyses with multiple comparisons. ..
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    ..Our results raise the possibility of sVCAM-1 in the fluid phase as a significant contributor to the heightened eosinophilic inflammatory response. ..