VCAM-1

Summary

Gene Symbol: VCAM-1
Description: vascular cell adhesion molecule 1
Alias: CD106, INCAM-100, CD106 antigen, vascular cell adhesion protein 1
Species: human

Top Publications

  1. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
  2. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
  3. doi Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis
    Jill K Slack-Davis
    Department of Microbiology, Health Evaluation Sciences and Cancer Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 69:1469-76. 2009
  4. doi Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells
    Tzu Ming Wang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan
    J Nutr Biochem 22:187-94. 2011
  5. ncbi HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
  6. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
  7. doi Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts
    Shue Fen Luo
    Chang Gung University, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan
    Arthritis Rheum 62:105-16. 2010
  8. ncbi Gp120 activates children's brain endothelial cells via CD4
    M F Stins
    Division of Infectious Diseases, Childrens Hospital Los Angeles, California, USA
    J Neurovirol 7:125-34. 2001
  9. doi Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea
    Atherosclerosis 207:412-9. 2009
  10. ncbi Anthrax lethal toxin enhances cytokine-induced VCAM-1 expression on human endothelial cells
    Amber D Steele
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Biochem Biophys Res Commun 337:1249-56. 2005

Detail Information

Publications237 found, 100 shown here

  1. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration...
  2. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
    ..VCAM-1, which belongs to the immunoglobulin gene super-family, may be central to recruitment of mononuclear leukocytes into inflammatory sites in vivo...
  3. doi Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis
    Jill K Slack-Davis
    Department of Microbiology, Health Evaluation Sciences and Cancer Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 69:1469-76. 2009
    ..Together, these observations implicate VCAM-1-alpha(4)beta(1) integrin interactions in the regulation of ovarian cancer cell mesothelial invasion and metastatic progression and offer the possibility of novel therapeutic targets...
  4. doi Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells
    Tzu Ming Wang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan
    J Nutr Biochem 22:187-94. 2011
    ..This study provides evidence that DHA may contribute to the prevention of atherosclerosis and inflammatory diseases in vivo...
  5. ncbi HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
    ..These data demonstrate that intracerebral administration of Tat can induce profound proinflammatory effects in the brain, leading to monocyte infiltration...
  6. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
    ..These data suggest that microRNA can regulate adhesion molecule expression and may provide additional control of vascular inflammation...
  7. doi Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts
    Shue Fen Luo
    Chang Gung University, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan
    Arthritis Rheum 62:105-16. 2010
    ..To investigate the roles of MAPKs and NF-kappaB in tumor necrosis factor alpha (TNFalpha)-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human rheumatoid arthritis synovial fibroblasts (RASFs)...
  8. ncbi Gp120 activates children's brain endothelial cells via CD4
    M F Stins
    Division of Infectious Diseases, Childrens Hospital Los Angeles, California, USA
    J Neurovirol 7:125-34. 2001
    ..Gp120-induced monocyte migration was inhibited by anti-gp120 and anti-CD4 antibodies. This is the first demonstration that gp120 activates HBMEC via CD4, which may contribute to the development of HIV-1 encephalopathy in children...
  9. doi Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea
    Atherosclerosis 207:412-9. 2009
    ....
  10. ncbi Anthrax lethal toxin enhances cytokine-induced VCAM-1 expression on human endothelial cells
    Amber D Steele
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Biochem Biophys Res Commun 337:1249-56. 2005
    ....
  11. pmc Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
    Qing Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 20:538-49. 2011
    ..Thus, newly disseminated cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway...
  12. pmc Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1
    Young Min Hyun
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 183:359-69. 2009
    ..These data suggest that a subpopulation of activated VLA-4 is mainly localized to the leading edge of polarized human T cells and is critical for T cell migration on VCAM-1...
  13. doi TLR4-dependent induction of vascular adhesion molecule-1 in rheumatoid arthritis synovial fibroblasts: Roles of cytosolic phospholipase A(2)alpha/cyclooxygenase-2
    Cheng Ying Wu
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 223:480-91. 2010
    ..Collectively, these results suggest that LPS-induced VCAM-1 expression and adhesion of THP-1 cells are mediated through the TLR4/ERK/cPLA(2)alpha phosphorylation and COX-2 expression/PGE(2) synthesis in RASFs...
  14. doi A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules
    Hongbin Liu
    Australian Centre for Blood Diseases, Monash University, Prahran, Melbourne, Victoria
    J Endocrinol 201:59-66. 2009
    ..These effects suggest that liraglutide may potentially improve the endothelial cell dysfunction associated with premature atherosclerosis identified in type 2 diabetic patients...
  15. ncbi Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes
    Ha Yong Song
    Department of Biomedical Science, Hallym University, Chuncheon 200 702, Korea
    Exp Mol Med 39:27-37. 2007
    ..These data indicate that HIV-1 Tat can modulate monocyte adhesiveness by increasing expression of adhesion molecules such as ICAM-1 and VCAM-1 via ROS- and NF-kappaB-dependent mechanisms in astrocytes...
  16. ncbi Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways...
  17. ncbi Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants
    Maria Annunziata Carluccio
    Consiglio Nazionale delle Ricerca Institute of Clinical Physiology, University of Lecce, Lecce, Italy
    Am J Physiol Heart Circ Physiol 293:H2344-54. 2007
    ..Natural Mediterranean diet antioxidants can inhibit such activation, suggesting their possible therapeutic role in Hcy-induced vascular damage...
  18. ncbi Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism
    Jason M Warfel
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892
    J Immunol 180:7516-24. 2008
    ..Altering the activity of key transcription factors involved in host response to infection may be a critical mechanism by which LT contributes to anthrax pathogenesis...
  19. ncbi Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells. Role of cyclic GMP and NF-kappaB
    Sang Koo Lee
    Department of Internal Medicine, College of Medicine, University of Ulsan, Seoul, Korea
    Nephron 90:447-54. 2002
    ..These results suggest that exogenous NO inhibits VCAM-1 expression via suppression of NF-kappaB through a cGMP-independent pathway...
  20. ncbi At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products
    Giuseppina Basta
    C N R Institutes of Clinical Physiology, Pisa, Italy
    Arterioscler Thromb Vasc Biol 25:1401-7. 2005
    ..We investigated the role of distinct sources of ROS, including the mitochondrial electron transport chain, NAD(P)H oxidase, xanthine oxidase, and arachidonic acid metabolism, in AGE-induced VCAM-1 expression...
  21. pmc Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients
    Hala El-Mesallamy
    Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt
    Mediators Inflamm 2007:73635. 2007
    ..P-selectin and ICAM-1 were significantly positively correlated. This study indicates that increased level of oxidative stress marker, proinflammatory markers, and their downstream effectors adhesion molecules occur in type 2 DM...
  22. doi Evidences for correlation between the reduced VCAM-1 expression and hyaluronan synthesis during cellular senescence of human mesenchymal stem cells
    Eun Mi Jung
    Integrative Omics Research Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 404:463-9. 2011
    ..Thus, we suggest that hyaluronan supplementation in expansion culture of MSCs would compensate adverse effects induced by its decreased synthesis and subsequently enhance cell adhesion and migration abilities...
  23. ncbi Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution
    E Y Jones
    Laboratory of Molecular Biophysics, Oxford Centre for Molecular Sciences, UK
    Nature 373:539-44. 1995
    ..These, and additional data, map VLA-4 binding to the face of the CFG beta-sheet, the surface previously identified as the site for intercellular adhesive interactions between members of the immunoglobulin superfamily...
  24. ncbi Caveolin-1 is associated with VCAM-1 dependent adhesion of gastric cancer cells to endothelial cells
    Jaeyoung Shin
    Department of Molecular Biology and Institute of Nanosensor and Biotechnology, Dankook Univiersity, Seoul, Korea
    Cell Physiol Biochem 17:211-20. 2006
    ....
  25. doi Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia
    Carlos J Veas
    Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, P O Box 237, Concepcion, Chile
    J Matern Fetal Neonatal Med 24:1371-7. 2011
    ..To evaluate the association between endothelial activation markers in the maternal circulation with nitric oxide (NO) synthesis in human umbilical endothelial cells...
  26. pmc Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells
    D H Ryan
    Department of Pathology, University of Rochester Medical Center, New York 14642
    J Clin Invest 88:995-1004. 1991
    ....
  27. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    ..It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3β/GATA-6 signaling cascade in TNF-α-treated ECs...
  28. doi A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model
    Tracey Gaspari
    Department of Pharmacology, Monash University, Australia
    Diab Vasc Dis Res 8:117-24. 2011
    ..Together these studies identify in vivo protection, by the GLP-1R agonist liraglutide, against ECD and provide a potential molecular mechanism responsible for these effects...
  29. ncbi Structure/function studies on vascular cell adhesion molecule-1
    B Pepinsky
    Biogen, Inc, Cambridge, Massachusetts 02142
    J Biol Chem 267:17820-6. 1992
    ....
  30. pmc P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line
    Olga J Baker
    Department of Biochemistry, University of Missouri Columbia, 540E Christopher S Bond Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211 0001, USA
    Mol Immunol 45:65-75. 2008
    ..These results suggest that P2Y2R activation in salivary gland cells increases the EGFR-dependent expression of VCAM-1 and the binding of lymphocytes, a pathway relevant to inflammation associated with SS...
  31. doi Immunohistochemical analysis of cellular adhesion molecules (ICAM-1, VCAM-1) and VEGF in fibrovascular membranes of patients with proliferative diabetic retinopathy: preliminary study
    T Khalfaoui
    Service d Ophtalmologie, Hopital Charles Nicolle, Boulevard du 9 Avril, Bab Souika, 1006 Tunis, Tunisia
    Pathol Biol (Paris) 57:513-7. 2009
    ..To this end, we analyzed the simultaneous expression of ICAM-1, VCAM-1 and VEGF within tissues of diabetic fibrovascular membranes...
  32. doi Gastrin induces the interaction between human mononuclear leukocytes and endothelial cells through the endothelial expression of P-selectin and VCAM-1
    Sales Ibiza
    Departamento de Farmacología and CIBERehd, Universidad de Valencia, Spain
    Am J Physiol Cell Physiol 297:C1588-95. 2009
    ..Gastrin induces interactions between human mononuclear leukocytes and endothelial cells through the activation of CCK-2 receptors and the enhancement of endothelial P-selectin and VCAM-1...
  33. ncbi Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts
    Rithwik Ramachandran
    Respiratory Medicine, Division of Academic Medicine, Post Graduate Medical Institute of the University of Hull in association with the Hull York Medical School, East Yorkshire, HU16 5JQ, United Kingdom
    Am J Respir Cell Mol Biol 35:133-41. 2006
    ..PAR2-driven upregulation of VCAM-1 cell surface expression and the release of IL-8 and G-CSF from bronchial fibroblasts may be important in promoting neutrophilic airways inflammation...
  34. pmc s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal
    Diana Rubin
    Max Rubner Institut, Federal Research Center of Nutrition and Food, Herrmann Weigmann Str 1, 24103 Kiel, Germany
    Lipids Health Dis 7:32. 2008
    ..We conducted assessment of association between postprandial triglycerides, insulin and glucose after ingestion of a standardized lipid-rich test meal, and soluble cellular adhesion molecules (sCAM) in young healthy subjects...
  35. doi Soluble vascular cell adhesion molecule-1 induces human eosinophil migration
    S Ueki
    Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan
    Allergy 64:718-24. 2009
    ..Elevated levels of the soluble forms of adhesion molecules in the body fluid of asthmatic patients have been observed, although their pathophysiological significance remains to be fully elucidated...
  36. pmc The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1
    Y Taooka
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, California 94143, USA
    J Cell Biol 145:413-20. 1999
    ..These observations suggest a possible role for alpha9beta1/VCAM-1 interactions in extravasation of neutrophils at sites of acute inflammation...
  37. ncbi The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways
    Juliette Fitau
    INSERM, U643, Nantes, France
    J Biol Chem 281:20148-59. 2006
    ..Collectively, our results identify the adaptor Lnk as a negative regulator in the TNFalpha-signaling pathway mediating ERK inhibition and suggest a role for Lnk in the interplay between PI3K and ERK triggered by TNFalpha in ECs...
  38. ncbi Alpha 4 beta 1 integrin/VCAM-1 interaction activates alpha L beta 2 integrin-mediated adhesion to ICAM-1 in human T cells
    J R Chan
    Department of Laboratory Medicine, University of Toronto, Toronto General Hospital Research Institute, Toronto, Canada
    J Immunol 164:746-53. 2000
    ..A role for the cytoskeleton is implicated in this process...
  39. ncbi VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells
    A L Lazaar
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 166:155-61. 2001
    ..These studies suggest that VCAM-1 is linked to multiple signaling pathways in human ASM cells and may function to augment growth factor-induced responses...
  40. ncbi The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1)
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Biol Chem 279:35679-86. 2004
    ..These data indicate a novel mechanism whereby a nucleotide receptor transactivates a receptor tyrosine kinase to generate an inflammatory response associated with atherosclerosis...
  41. ncbi The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells
    Cheikh I Seye
    Department of Biochemistry, University of Missouri, Columbia 65212, USA
    J Biol Chem 278:24960-5. 2003
    ..These findings suggest a novel role for the P2Y2 receptor in the p38- and Rho kinase-dependent expression of VCAM-1 that mediates the recruitment of monocytes by vascular endothelium associated with the development of atherosclerosis...
  42. ncbi IL-13 regulates vascular cell adhesion molecule-1 expression in human osteoblasts
    Leonard Rifas
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Cell Biochem 89:213-9. 2003
    ....
  43. ncbi VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration
    Sandra van Wetering
    Department of Experimental Immunohematology, Sanquin Research at CLB, 1066 CX Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 285:C343-52. 2003
    ..Together, these data indicate that VCAM-1-induced, Rac-dependent signaling plays a key role in the modulation of vascular-endothelial cadherin-mediated endothelial cell-cell adhesion and leukocyte extravasation...
  44. doi Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production
    Masahiro Abe
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Bone Miner Metab 27:16-23. 2009
    ....
  45. pmc ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)
    Suzette J Bielinski
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Atherosclerosis 201:339-44. 2008
    ..Our results identified ICAM1 polymorphisms that were significantly associated with sICAM-1 level but not CAC, a subclinical marker of atherosclerosis...
  46. ncbi 11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression
    J R Falck
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Bioorg Med Chem Lett 13:4011-4. 2003
    ..A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET...
  47. ncbi Elevation of soluble VCAM-1 plasma levels in children with acute dengue virus infection of varying severity
    Penelopie Koraka
    Laboratory for Exotic Viral Infections, Institute of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Med Virol 72:445-50. 2004
    ..These data also favor to study the further elucidation of the role of sVCAM-1 in the pathogenesis of dengue infections...
  48. ncbi Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells
    Wei Ning Lin
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Cell Signal 19:1258-67. 2007
    ..These results provide new insight into the mechanisms of LPS action that bacterial toxins may promote inflammatory responses in the airway disease...
  49. ncbi TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
    Zhigang Zhou
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Cell Signal 19:1238-48. 2007
    ....
  50. ncbi Carbamylated low-density lipoprotein induces monocyte adhesion to endothelial cells through intercellular adhesion molecule-1 and vascular cell adhesion molecule-1
    Eugene O Apostolov
    Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 27:826-32. 2007
    ..This study was aimed at testing the hypothesis that carbamylated LDL acts via inducing monocyte adhesion to endothelial cells and determining the adhesion molecules responsible for the recruitment of monocytes...
  51. ncbi Gliclazide treatment lowers serum ICAM-1 levels in poorly controlled type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Diabetes Metab 32:344-9. 2006
    ..To investigate the potential effect of gliclazide on serum ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) levels in poorly controlled type 2 diabetic patients...
  52. ncbi The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon
    Hanna Harant
    Novartis Institutes for BioMedical Research, A 1235 Vienna, Austria
    J Biol Chem 281:30492-502. 2006
    ..Our data indicate that the compound inhibits translocation of VCAM1 by interfering with correct insertion of its signal peptide into the translocon...
  53. ncbi VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation
    Manuela Gavina
    Stem Cell Laboratory, Department of Neurological Sciences, IRCCS, Centro Dino Ferrari, University of Milan, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Blood 108:2857-66. 2006
    ....
  54. ncbi Contrasting roles for domain 4 of VCAM-1 in the regulation of cell adhesion and soluble VCAM-1 binding to integrin alpha4beta1
    Darren G Woodside
    Encysive Pharmaceuticals Incorporated, Houston, TX 77030, USA
    J Immunol 176:5041-9. 2006
    ..These results indicate that the domain 4 of VCAM-1 plays a contrasting role when VCAM-1 is presented in solution or as a cell surface-expressed adhesive substrate...
  55. ncbi C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells
    Daiji Kawanami
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Atherosclerosis 185:39-46. 2006
    ..Taken together, our findings suggest that VCAM-1 induction by CRP is mediated by PKC, p38MAPK, tyrosine kinase and the NF-kappaB-dependent signaling pathways in vascular endothelial cells...
  56. doi Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy
    Mariusz Nowak
    Pathophysiology Division, Department of Pathophysiology and Endocrinology, Medical University of Silesia, 41 800 Zabrze pl, Traugutta 2, Poland
    Clin Exp Med 8:159-64. 2008
    ....
  57. doi Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells
    Rosalinda Madonna
    Institute of Cardiology, Center of Excellence on Aging, G d Annunzio University Chieti, Italy
    Biochim Biophys Acta 1782:511-6. 2008
    ..Therefore, hyperinsulinemia enhances cytokine-induced VCAM-1 expression in endothelial cells, thus potentially contributing to detrimental effects of other inflammatory stimuli on atherogenesis...
  58. ncbi HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling
    Kai Liu
    Department of Medicine, Tulane Univ School of Medicine, New Orleans, LA 70112 2699, USA
    Am J Physiol Lung Cell Mol Physiol 289:L252-60. 2005
    ....
  59. doi Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives
    R V Vince
    Department of Sport, Health and Exercise Science, University of Hull, Hull, UK
    Eur J Appl Physiol 105:507-13. 2009
    ..095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness...
  60. doi The distinction between lesional and non-lesional skin in psoriasis vulgaris through expression of adhesion molecules ICAM-1 and VCAM-1
    Leo Cabrijan
    Department of Dermatovenerology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia
    Med Hypotheses 72:327-9. 2009
    ..Our hypothesis could be proved by immunohistochemical stain of ICAM-1 and VCAM-1 in lesional and non-lesional skin of pv patient in comparison with healthy skin...
  61. pmc Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1
    Yannick Allanore
    Paris V University, Department of Rheumatology A, Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
    Arthritis Res Ther 6:R309-14. 2004
    ..However, more experimental evidence is needed to determine whether the VEGF pathway is intrinsically defective in SSc...
  62. ncbi Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes
    Mats W Johansson
    Department of Medicine, University of Wisconsin, 4285A, Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Am J Respir Cell Mol Biol 31:413-22. 2004
    ..Podosome-mediated VCAM-1 clearance may be a mechanism to regulate eosinophil arrest and extravasation in allergic conditions such as asthma...
  63. ncbi Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation
    T S Altannavch
    Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Czech Republic
    Physiol Res 53:77-82. 2004
    ..These results show that even a short-term exposure of endothelial cells (ECs) to high glucose concentration leads to their activation associated with increased expression of adhesion molecules such as ELAM-1, VCAM-1 and ICAM-1...
  64. ncbi Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis
    Jose Figueras-Aloy
    Servicio Neonatología, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Spain
    Am J Perinatol 24:331-8. 2007
    ..These levels were related to the clinical severity of the disease. Soluble VCAM-1 levels increased only slightly in HC + sepsis. Soluble L-selectin and sP-selectin did not change...
  65. ncbi Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
    J P Levesque
    Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 98:1289-97. 2001
    ....
  66. pmc Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    Olga Barreiro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Cell Biol 157:1233-45. 2002
    ..These results provide the first characterization of an endothelial docking structure that plays a key role in the firm adhesion of leukocytes to the endothelium during inflammation...
  67. ncbi Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions
    Joshua A Boyce
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 99:2890-6. 2002
    ..These observations may explain the abundance of MCs at sites of mucosal inflammation, where VCAM-1 and E-selectin are important inducible receptors...
  68. ncbi Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein
    Martin F Crook
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, UK
    J Vasc Res 39:221-9. 2002
    ..These experiments imply that either integrin might be targeted to reduce monocyte infiltration into HSV grafts...
  69. ncbi Modulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 on human coronary smooth muscle cells by cytokines
    M Braun
    Medizinische Klinik, Universitatsklinikum Charite, Humboldt Universitat zu Berlin, Germany
    J Mol Cell Cardiol 27:2571-9. 1995
    ..These results demonstrate that cytokines regulate ICAM-1 and VCAM-1 expression on human coronary and pulmonary smooth muscle cells. These effects may play an important role in the immune mechanisms in atherosclerosis...
  70. ncbi Testosterone inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells
    Haruhiko Hatakeyama
    Department of Internal Medicine, Division of Endocrinology, Kanazawa Medical University, Ishikawa 920 0293, Japan
    FEBS Lett 530:129-32. 2002
    ..Our results may suggest an inhibitory effect of T on atherogenesis, providing a novel insight into the consideration of the pathogenesis of atherosclerosis...
  71. ncbi Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)
    M F Iademarco
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 267:16323-9. 1992
    ..The distribution of these proteins could then control activity of the NF kappa B sites. We conclude that the pattern of VCAM-1 expression in HUVECs is controlled by a combination of these silencers and NF kappa B sites...
  72. ncbi Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells
    Mushtaq Ahmad
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 22:759-64. 2002
    ..Thus, ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway, and it appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1...
  73. ncbi Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors
    Monique F Stins
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Lab Invest 83:1787-98. 2003
    ..The activation of brain endothelium of children by HIV-1 protein gp120 by way of CD4 and chemokine receptors may have implications for the pathogenesis of HIV-1 encephalopathy in the pediatric population...
  74. ncbi The influence of garlic (Allium sativum) extract on interleukin 1alpha-induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1
    F Rassoul
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Phytomedicine 13:230-5. 2006
    ..molecules such as intercellular adhesion molecule-1 (ICAM-1, CD54) and vascular cell adhesion molecule-1 (VCAM-1, CD106)...
  75. ncbi Adhesion molecule mechanisms mediating monocyte migration through synovial fibroblast and endothelium barriers: role for CD11/CD18, very late antigen-4 (CD49d/CD29), very late antigen-5 (CD49e/CD29), and vascular cell adhesion molecule-1 (CD106)
    X Z Shang
    Department of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 160:467-74. 1998
    ..In addition to VCAM-1, other ligand(s) on HSF are also involved in the VLA-4-mediated migration...
  76. ncbi Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice
    A Jakubowski
    Biogen, Inc, Cambridge, MA 02142, USA
    J Immunol 155:938-46. 1995
    ..and development through its interactions with two alternate ligands, vascular cell adhesion molecule-1 (VCAM-1; CD106) expressed on cytokine-activated endothelium, dendritic and stromal cells, and the extracellular matrix protein ..
  77. ncbi Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells
    T Kinashi
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115
    J Leukoc Biol 57:168-73. 1995
    Monoclonal antibodies to murine vascular cell adhesion molecule-1 (VCAM-1, CD106) revealed not only the expected VCAM-1 molecule with an apparent molecular weight of 100 kDa, but also a molecule with a smaller size of 46 kDa in stromal ..
  78. ncbi Cloning of an inflammation-specific phosphatidyl inositol-linked form of murine vascular cell adhesion molecule-1
    P Moy
    Biogen, Incorporated, Cambridge, Massachusetts 02142
    J Biol Chem 268:8835-41. 1993
    ..3D-VCAM1 is found only in endotoxin-treated but not control murine and rat tissues. Thus in rodents alternate splicing of the VCAM1 gene generates a unique truncated inflammation-specific phosphatidylinositol-linked form of VCAM1...
  79. doi An association analysis between a silent C558T polymorphism at the pig vascular cell adhesion molecule 1 locus and sow reproduction and piglet survivability traits
    O Ramirez
    Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Barcelona, Spain
    Reprod Domest Anim 43:542-6. 2008
    ..013) as well as a significant one with time to make the first ingestion of colostrum (p = 0.003). The biological basis of these associations remains unclear and they should be interpreted with caution...
  80. ncbi IL-1 activation of endothelium supports VLA-4 (CD49d/CD29)-mediated monocyte transendothelial migration to C5a, MIP-1 alpha, RANTES, and PAF but inhibits migration to MCP-1: a regulatory role for endothelium-derived MCP-1
    H E Chuluyan
    Department of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 58:71-9. 1995
    ..e., E-selectin (CD62E), intercellular adhesion molecule-1 (CD54) or vascular cell adhesion molecule-1 (CD106), did not reverse the inhibitory effect...
  81. pmc Therapeutic effect of all-trans-retinoic acid (at-RA) on an autoimmune nephritis experimental model: role of the VLA-4 integrin
    Maria M Escribese
    Department of Pathology, Hospital Ramon y Cajal, Universidad de Alcala, Madrid, Spain
    BMC Nephrol 8:3. 2007
    ..We assessed the effects of all-trans retinoic acid (at-RA) in this experimental model. At-RA is a vitamin A metabolite which has shown beneficial effects on several nephropathies, even though no clear targets for at-RA were provided...
  82. doi Effects of macrolides on proinflammatory epitopes on endothelial cells in vitro
    Michael Millrose
    Institute of Clinical Pharmacology and Toxicology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Arch Toxicol 83:469-76. 2009
    ..monoclonal antibodies for the following surface antigens: CD34, E-selectin (CD62E), ICAM-1 (CD54) and VCAM-1 (CD106)...
  83. doi Endothelial/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis
    Mirko Manetti
    University of Florence, Florence, Italy
    Arthritis Rheum 58:2866-73. 2008
    ..The aim of the present study was to investigate whether immune and/or microvascular abnormalities may account for tissue damage in gastric wall specimens obtained from patients with SSc...
  84. ncbi Expression of cell adhesion molecules in chordomas: an immunohistochemical study of 16 cases
    Hidehisa Horiguchi
    Department of Pathology, University of Tokushima School of Medicine, 3 18 15 Kuramoto, 770 8503 Tokushima, Japan
    Acta Neuropathol 107:91-6. 2004
    ..molecules, E-cadherin, P-cadherin, N-cadherin, beta-catenin, CD44, ICAM-1 (CD54), NCAM (CD56), and VCAM-1 (CD106) in 16 tumors from 16 patients (skull base, n=5; cervical, n=2; sacral, n=9) and 3 cases of fetal notochord...
  85. ncbi [Migratory and chemoattractant responses of mesenchymal stem cells to oxidative stress injury of endothelial cell in vitro]
    Zhi Li Zhao
    Aesthetic and Plastic Surgery Center, Dermatology Diagnosis and Treatment Center of PLA, General Hospital of Beijing Military Command, Beijing 100700, China
    Zhonghua Yi Xue Za Zhi 89:1577-81. 2009
    ..To investigate the possibilities of human mesenchymal stem cells (hMSCs) migrating toward the oxidative stress injuries of endothelial cells...
  86. ncbi The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106
    D H Lee
    R W Johnson Pharmaceutical Research Institute, Don Mills, Ontario, Canada
    Immunol Lett 53:109-13. 1996
    ..CD11b/CD18 on monocytic HL60 cells, and endothelial adhesion molecule-1 (CD62E) and vascular adhesion molecule-1 (CD106) on human umbilical vein endothelial cells...
  87. ncbi Immunological and ultrastructural characterization of endothelial cell cultures differentiated from human cord blood derived endothelial progenitor cells
    Josef Neumüller
    Center for Anatomy and Cell Biology, Department of Cell Biology and Ultrastructure Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Histochem Cell Biol 126:649-64. 2006
    ..EPC showed surface expression of CD54 and CD106. However, only a small portion of HSCs-derived EPCs was positive for CD54 but negative for CD106...
  88. ncbi Effect of vascular stent alloys on expression of cellular adhesion molecules by endothelial cells
    Regina L W Messer
    Medical College of Georgia, Augusta, Georgia 30912 1100, USA
    J Long Term Eff Med Implants 15:39-47. 2005
    ..Expression of these CAMs is a critical step in the long-term inflammatory response to stent materials and possibly to in-stent restenonsis...
  89. doi Up-regulation of adhesion molecule expression and induction of TNF-alpha on vascular endothelial cells by antibody against human parvovirus B19 VP1 unique region protein
    Bor Show Tzang
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Clin Chim Acta 395:77-83. 2008
    ..However, the precise role of B19-VP1u in induction of APS is still obscure...
  90. ncbi CD106 (VCAM-1) in testicular immunoregulation
    S Sainio-Pöllänen
    Department of Anatomy, University of Turku, Finland
    J Reprod Immunol 33:221-38. 1997
    The expression of CD18, CD49d/CD29, CD44, CD54 and CD106 was studied in the testis of normal mice at various ages, in the cryptorchid testis, in the testis of estrogen-treated mice and in the testis of non-obese diabetic (NOD) mice, ..
  91. ncbi Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells
    G Koopman
    Department of Pathology, University of Amsterdam, The Netherlands
    J Immunol 152:3760-7. 1994
    ..Previously, we have shown that the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and VLA-4 (CD49d)-VCAM-1 (CD106) adhesion pathways are involved in FDC-B cell interaction...
  92. doi Toward the identification of mesenchymal stem cells in bone marrow and peripheral blood for bone regeneration
    Dennis Smiler
    Oral and Maxillofacial Surgeon, Encino, CA, USA
    Implant Dent 17:236-47. 2008
    ..Specific markers exist for cells related to bone healing and bone regeneration. These include but are not limited to hematopoietic, mesenchymal, endothelial, angiogenic, and vasculargenic precursor cells...
  93. ncbi Soluble cellular adhesion molecules, selectins, VEGF and endothelin-1 in patients with Wuchereria bancrofti infection and association with clinical status
    P Esterre
    Immunology Unit, Institut de Recherches Medicales Malarde, Papeete 98713 Tahiti French Polynesia
    Parasite Immunol 27:9-16. 2005
    ..increased serum concentrations of soluble intercellular (sICAM-1, CD54), but not of vascular cell (sVCAM-1, CD106), adhesion molecules were observed in sera of patients with bacterial lymphangitis used as controls...
  94. ncbi The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
    M Mahlapuu
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    Development 128:155-66. 2001
    ....
  95. ncbi Experimental testicular teratoma promotes formation of humoral immune responses in the host testis
    J Sundstrom
    Department of Anatomy, University of Turku, Finland
    J Reprod Immunol 42:107-26. 1999
    ..response of the host testis against experimental testicular teratoma in mouse by localizing adhesion molecules (CD106, CD54, CD49d/CD29, CD44, CD18, CD8 and CD4), cytokines (IL-2, IL-4, IL-6, IL-10 and IL-12), T-cell costimulators (..
  96. ncbi Human umbilical cord blood-derived stromal cell, a new resource of feeder layer to expand human umbilical cord blood CD34+ cells in vitro
    Lei Gao
    Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, People s Republic of China
    Blood Cells Mol Dis 36:322-8. 2006
    ..Our research found that hUCB-derived stromal cells were mainly composed of three kinds of cell components, with CD106, CD29, CD44, CD45, CD50, CD68, CD31, Fn, Lm, and collagen IV positive, but CD34 negative immunophenotype...
  97. ncbi Role of PPAR in cardiovascular diseases
    Saibal Kumar Das
    Metabolic Disorders Group, Dr Reddy s Lab, Discovery Research, Bollaram Road, Miyapur, Hyderabad 500049, India
    Recent Pat Cardiovasc Drug Discov 1:193-209. 2006
    ..This review intends to capture some of the key studies in this area as is described in some recent patents and literature...
  98. ncbi [Effects of recombinant human thrombopoietin on stromal cells in culture in vitro]
    Jian Liang Shen
    Department of Hematology, PLA Naval General Hospital, Beijing 100037, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1430-6. 2008
    ..These alterations were not different among various groups. The expressions of CD34, CD45, CD105, CD106, and CD166 were not affected obviously by rhTPO...
  99. ncbi Precise mapping of breakpoints in conserved synteny between human chromosome 1 and pig chromosomes 4, 6 and 9
    H S Sun
    Department of Animal Science, Iowa State University, Ames, IA, USA
    Anim Genet 33:91-6. 2002
    ..Further, our data predict that Hsap1q21-24 is a candidate region for the backfat QTL localized to Sscr4...
  100. doi Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Cardiovasc Pathol 17:226-32. 2008
    ..As paraoxonase-1 has been recently shown to be a lactonase, its functional role remains to be fully elucidated. We explored additional vascular changes in Pon1 knockout mice in the absence of atherogenic diet challenge...
  101. ncbi Prenatal diagnosis of beta-thalassemia in the West Bank and Gaza
    Suhail K Ayesh
    Director of Molecular Genetics Laboratory, Makassed Islamic Charitable Hospital, Mount of Olives, 91194 Jerusalem
    Saudi Med J 26:1771-6. 2005
    ..This study focuses on the genetic aspect of beta-thalassemia among 88 at risk couples from the West Bank and Gaza, and the attitude of these couples toward prenatal diagnosis and its outcome as a preventive method...

Research Grants85

  1. Hyposialylation Regulates Alpha4Beta1 Integrin Binding to VCAM1
    ALENCIA WOODARD GRICE; Fiscal Year: 2007
    ....
  2. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2010
    ..The findings may also improve risk assessment of health effects of arsenic exposure. ..
  3. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven Shoelson; Fiscal Year: 2007
    ..The findings will improve our understanding of the role of subacute 'inflammation' in insulin resistance, T2D and the metabolic syndrome, and may identify new and more selective targets for therapeutic intervention. ..
  4. PATHWAY OF VENTRICULAR MORPHOGENESIS MEDICATED BY RXRA
    Henry Sucov; Fiscal Year: 2001
    ..abstract_text> ..
  5. Cellular Assay:Presentation of the Adhesion Molecul(RMI)
    Thomas Mayer; Fiscal Year: 2005
    ..The assay can generate data with high confidence and a Z' factor of 0.80. We have also shown that the assay is a powerful tool to screen for bioactive compounds. ..
  6. MOLECULAR DETERMINANTS OF BRAIN-METASTATIC MELANOMA
    Dario Marchetti; Fiscal Year: 2010
    ..Research outlined here will help in delineating molecular events associated with malignant melanoma growth and brain metastasis, as influenced by enzyme-driven interactions between tumor cells and extracellular matrix ..
  7. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..The hypothesis is that cardiac fibrosis will be regulated by urokinase activity and other functions of PAI-I which will be further pursued in future studies of mice expressing functional mutations of PAI-1. ..
  8. Novel Eicosanoids: Synthesis and Function
    John R Falck; Fiscal Year: 2010
    ..It is the long-term objective of this laboratory to identify these metabolites, develop biochemical and chemical tools to better understand their physiologic roles, and ultimately intervene pharmacologically. ..
  9. Sphingosine Kinase as a Target for Cancer Therapy
    Charles D Smith; Fiscal Year: 2010
    ....
  10. ACYLTRANSFERASE INHIBITORS AS ANTI RAS AGENTS
    Charles Smith; Fiscal Year: 2009
    ..abstract_text> ..
  11. Dev. of Optimized/Adjuvanted Smallpox DNA Vaccine (Gene Gun)
    T C Wu; Fiscal Year: 2007
    ..The successful implementation of the proposed studies will result in an improved poxvirus DNA vaccine potentially suitable for clinical development. ..
  12. Novel Eicosanoids: Synthesis and Function
    John Falck; Fiscal Year: 2007
    ..3) Develop isozyme-specific P450 inhibitors using (i) structure based rational design; (ii) computational/molecular modeling; and (iii) library screening. ..
  13. Mechanisms of VEGF modulation of smooth muscle function
    AILI LAZAAR; Fiscal Year: 2006
    ....
  14. NOVEL EICOSANOIDS--ANALYSIS, SYNTHESIS, AND FUNCTION
    John Falck; Fiscal Year: 1999
    ..and (e) elucidation of the P450 active site. ..
  15. EICOSANOID SYNTHESIS
    John Falck; Fiscal Year: 1991
    ..In light of the almost universal distribution of cytochrome P-450 in mammalian tissues, this work will have profound implications for our understanding of fatty acid metabolism and its relationship to homeostasis...
  16. ACYLTRANSFERASE INHIBITORS AS ANTI RAS AGENTS
    Charles Smith; Fiscal Year: 2005
    ..These studies should confirm our identification of HIP3 as the first oncogenic human PAT, provide insight into the biological roles of HIP3 and other hPATs, and validate HIP3 as a target for the development of anticancer drugs. ..
  17. ADHESION MOLECULES IN SMOOTH MUSCLE ACTIVATION & GROWTH
    AILI LAZAAR; Fiscal Year: 2003
    ..Understanding the mechanisms by which CAMs transduce signals that could induce myocyte activation may provide insight in new therapeutic measures to prevent airway inflammation and bronchial hyperreactivity. ..
  18. NOVEL EICOSANOIDS: ANALYSIS, SYNTHESIS, AND FUNCTION
    John Falck; Fiscal Year: 2003
    ..and (e) elucidation of the P450 active site ..
  19. Imaging of progenitor cells in tumor environments
    Jennifer Allport; Fiscal Year: 2002
    ..abstract_text> ..
  20. NOVEL COMPOUNDS WHICH CIRCUMVENT MULTIDRUG RESISTANCE
    Charles Smith; Fiscal Year: 2001
    ..These studies should allow a critical evaluation of the potential utility of these novel compounds as clinical agents. ..
  21. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2005
    ..The primary method of analysis will be twin structural equation modeling. ..
  22. ENHANCEMENT OF HPV16 E6 & E7-SPECIFIC ANTITUMOR IMMUNITY
    T C Wu; Fiscal Year: 2001
    ..5) Perform head-to-head comparison of various E6, E7 and chimeric E6E7 vaccines in antitumor immunity using E6 and E7 expressing murine model tumors. ..
  23. ENHANCING HPV-16 E6-SPECIFIC ANTITUMOR IMMUNITY
    T C Wu; Fiscal Year: 2009
    ..abstract_text> ..
  24. PREVENTIVE/THERAPEUTIC HPV VACCINE DEVELOPMENT
    T C Wu; Fiscal Year: 2003
    ..A.5 Evaluate the mechanisms of the anti-tumor immunity induced by vaccination. ..
  25. Novel Eicosanoids: Synthesis and Function
    John Falck; Fiscal Year: 2009
    ..It is the long-term objective of this laboratory to identify these metabolites, develop biochemical and chemical tools to better understand their physiologic roles, and ultimately intervene pharmacologically. ..