VCAM-1

Summary

Gene Symbol: VCAM-1
Description: vascular cell adhesion molecule 1
Alias: CD106, INCAM-100, CD106 antigen
Species: human

Top Publications

  1. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
  2. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
  3. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
  4. pmc Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier
    Marianne Strazza
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Res 1399:96-115. 2011
  5. pmc VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
    Xin Lu
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cancer Cell 20:701-14. 2011
  6. pmc Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis
    Qing Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 18:5520-5. 2012
  7. ncbi Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1
    Jürgen Besemer
    Novartis Institutes for BioMedical Research, Brunner Strasse 59, A 1235 Vienna, Austria
    Nature 436:290-3. 2005
  8. pmc Epidermal growth factor (EGF)-enhanced vascular cell adhesion molecule-1 (VCAM-1) expression promotes macrophage and glioblastoma cell interaction and tumor cell invasion
    Yanhua Zheng
    From the Brain Tumor Center and Department of Neuro Oncology
    J Biol Chem 288:31488-95. 2013
  9. pmc IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal
    Chongxiu Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Circ Res 111:1054-64. 2012
  10. ncbi TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
    Zhigang Zhou
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Cell Signal 19:1238-48. 2007

Detail Information

Publications274 found, 100 shown here

  1. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration...
  2. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
    ..VCAM-1, which belongs to the immunoglobulin gene super-family, may be central to recruitment of mononuclear leukocytes into inflammatory sites in vivo...
  3. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
    ..These data suggest that microRNA can regulate adhesion molecule expression and may provide additional control of vascular inflammation...
  4. pmc Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier
    Marianne Strazza
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Brain Res 1399:96-115. 2011
    ....
  5. pmc VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
    Xin Lu
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cancer Cell 20:701-14. 2011
    ..These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone...
  6. pmc Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis
    Qing Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 18:5520-5. 2012
    ..S. Food and Drug Administration approval or are undergoing clinical trials. Testing these drugs against tumor-stromal leukocyte interactions may provide a new strategy to suppress lung and bone relapse of breast cancer...
  7. ncbi Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1
    Jürgen Besemer
    Novartis Institutes for BioMedical Research, Brunner Strasse 59, A 1235 Vienna, Austria
    Nature 436:290-3. 2005
    ..In addition, they highlight cotranslational translocation at the ER membrane as a potential target for drug discovery...
  8. pmc Epidermal growth factor (EGF)-enhanced vascular cell adhesion molecule-1 (VCAM-1) expression promotes macrophage and glioblastoma cell interaction and tumor cell invasion
    Yanhua Zheng
    From the Brain Tumor Center and Department of Neuro Oncology
    J Biol Chem 288:31488-95. 2013
    ....
  9. pmc IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal
    Chongxiu Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Circ Res 111:1054-64. 2012
    ..Diets high in polyunsaturated fatty acids (PUFAs) may provide athero-protection by ameliorating this effect...
  10. ncbi TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
    Zhigang Zhou
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Cell Signal 19:1238-48. 2007
    ....
  11. doi Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis
    Jill K Slack-Davis
    Department of Microbiology, Health Evaluation Sciences and Cancer Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 69:1469-76. 2009
    ..Together, these observations implicate VCAM-1-alpha(4)beta(1) integrin interactions in the regulation of ovarian cancer cell mesothelial invasion and metastatic progression and offer the possibility of novel therapeutic targets...
  12. doi Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells
    Tzu Ming Wang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei 112, Taiwan
    J Nutr Biochem 22:187-94. 2011
    ..This study provides evidence that DHA may contribute to the prevention of atherosclerosis and inflammatory diseases in vivo...
  13. ncbi High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers
    Martin Klemke
    Institute for Immunology, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 212:368-74. 2007
    ..These data imply that only high affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells...
  14. doi A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model
    Tracey Gaspari
    Department of Pharmacology, Monash University, Australia
    Diab Vasc Dis Res 8:117-24. 2011
    ..Together these studies identify in vivo protection, by the GLP-1R agonist liraglutide, against ECD and provide a potential molecular mechanism responsible for these effects...
  15. ncbi HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
    ..These data demonstrate that intracerebral administration of Tat can induce profound proinflammatory effects in the brain, leading to monocyte infiltration...
  16. ncbi Structural and functional studies of full-length vascular cell adhesion molecule-1: internal duplication and homology to several adhesion proteins
    T Polte
    Otsuka America Pharmaceutical Inc, Maryland Research Laboratories, Rockville 20850
    DNA Cell Biol 10:349-57. 1991
    ....
  17. pmc Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes
    Javier Conde
    NEIRID Lab NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital, Institute of Medical Research IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e52533. 2012
    ..There are several factors involved in the pathogenesis of these diseases including pro-inflammatory cytokines, adipokines and adhesion molecules...
  18. doi Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules
    Shi Quan Liu
    Department of Gastroenterology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Autonomous Region 530021, P R China
    Int J Oncol 42:617-26. 2013
    ..FAK pathway, ICAM-1 and VCAM-1 may play critical roles in this SphK1‑mediated effect...
  19. pmc The role of vascular cell adhesion molecule-1 in tumor immune evasion
    T C Wu
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 67:6003-6. 2007
    ..Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape...
  20. pmc Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression
    Ssang Taek Lim
    Department of Reproductive Medicine, University of California San Diego, Moores Cancer Center, La Jolla, CA 92093, USA
    J Cell Biol 197:907-19. 2012
    ..These studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover...
  21. ncbi Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis
    P A Klimiuk
    Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Bialystok, Poland
    Scand J Rheumatol 36:345-50. 2007
    ..The aim of the study was to analyse serum concentrations of soluble cell adhesion molecules (CAMs) in patients with early rheumatoid arthritis (RA) before and after 6 months of treatment with methotrexate (MTX)...
  22. pmc Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street Room 255 Philadelphia, PA 19107, USA
    ScientificWorldJournal 2012:482575. 2012
    ....
  23. pmc The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression
    H Song
    Vth Medical Department, University Hospital Mannheim, Mannheim, Germany
    Br J Pharmacol 157:769-80. 2009
    ....
  24. pmc Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression
    Edith Lubos
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    FASEB J 24:2525-32. 2010
    ..Taken together, these data suggest that GPx-1 modulates the endothelial cell response to LPS, in part, by altering CD14-mediated effects...
  25. ncbi Gp120 activates children's brain endothelial cells via CD4
    M F Stins
    Division of Infectious Diseases, Childrens Hospital Los Angeles, California, USA
    J Neurovirol 7:125-34. 2001
    ..Gp120-induced monocyte migration was inhibited by anti-gp120 and anti-CD4 antibodies. This is the first demonstration that gp120 activates HBMEC via CD4, which may contribute to the development of HIV-1 encephalopathy in children...
  26. ncbi Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants
    Maria Annunziata Carluccio
    Consiglio Nazionale delle Ricerca Institute of Clinical Physiology, University of Lecce, Lecce, Italy
    Am J Physiol Heart Circ Physiol 293:H2344-54. 2007
    ..Natural Mediterranean diet antioxidants can inhibit such activation, suggesting their possible therapeutic role in Hcy-induced vascular damage...
  27. ncbi Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes
    Ha Yong Song
    Department of Biomedical Science, Hallym University, Chuncheon 200 702, Korea
    Exp Mol Med 39:27-37. 2007
    ..These data indicate that HIV-1 Tat can modulate monocyte adhesiveness by increasing expression of adhesion molecules such as ICAM-1 and VCAM-1 via ROS- and NF-kappaB-dependent mechanisms in astrocytes...
  28. pmc Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
    Qing Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 20:538-49. 2011
    ..Thus, newly disseminated cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway...
  29. ncbi Anthrax lethal toxin enhances cytokine-induced VCAM-1 expression on human endothelial cells
    Amber D Steele
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Biochem Biophys Res Commun 337:1249-56. 2005
    ....
  30. doi TLR4-dependent induction of vascular adhesion molecule-1 in rheumatoid arthritis synovial fibroblasts: Roles of cytosolic phospholipase A(2)alpha/cyclooxygenase-2
    Cheng Ying Wu
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 223:480-91. 2010
    ..Collectively, these results suggest that LPS-induced VCAM-1 expression and adhesion of THP-1 cells are mediated through the TLR4/ERK/cPLA(2)alpha phosphorylation and COX-2 expression/PGE(2) synthesis in RASFs...
  31. doi Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea
    Atherosclerosis 207:412-9. 2009
    ....
  32. doi A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules
    Hongbin Liu
    Australian Centre for Blood Diseases, Monash University, Prahran, Melbourne, Victoria
    J Endocrinol 201:59-66. 2009
    ..These effects suggest that liraglutide may potentially improve the endothelial cell dysfunction associated with premature atherosclerosis identified in type 2 diabetic patients...
  33. pmc Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1
    Young Min Hyun
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 183:359-69. 2009
    ..These data suggest that a subpopulation of activated VLA-4 is mainly localized to the leading edge of polarized human T cells and is critical for T cell migration on VCAM-1...
  34. ncbi Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways...
  35. doi Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway
    Wei Yen Hsu
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 226:2181-8. 2011
    ..Taken together, these results show that resistin increases both the expression of ICAM-1 and VCAM-1 by endothelial cells and monocyte adhesion to HUVECs via p38MAPK-dependent pathways...
  36. ncbi Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism
    Jason M Warfel
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892
    J Immunol 180:7516-24. 2008
    ..Altering the activity of key transcription factors involved in host response to infection may be a critical mechanism by which LT contributes to anthrax pathogenesis...
  37. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    ..It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3β/GATA-6 signaling cascade in TNF-α-treated ECs...
  38. ncbi Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation
    T S Altannavch
    Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Czech Republic
    Physiol Res 53:77-82. 2004
    ..These results show that even a short-term exposure of endothelial cells (ECs) to high glucose concentration leads to their activation associated with increased expression of adhesion molecules such as ELAM-1, VCAM-1 and ICAM-1...
  39. ncbi Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells. Role of cyclic GMP and NF-kappaB
    Sang Koo Lee
    Department of Internal Medicine, College of Medicine, University of Ulsan, Seoul, Korea
    Nephron 90:447-54. 2002
    ..These results suggest that exogenous NO inhibits VCAM-1 expression via suppression of NF-kappaB through a cGMP-independent pathway...
  40. doi Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-κB/COX-2 signaling in human aortic endothelial cells
    Francesco Addabbo
    Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy
    Am J Physiol Endocrinol Metab 301:E1143-54. 2011
    ....
  41. ncbi Circulating soluble vascular cell adhesion molecule 1: relationships with residual renal function, cardiac hypertrophy, and outcome of peritoneal dialysis patients
    Angela Yee Moon Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Am J Kidney Dis 45:715-29. 2005
    ..In this study, we examined circulating soluble VCAM-1 (sVCAM-1) in relation to different clinical and biochemical parameters, as well as mortality and cardiovascular events, in peritoneal dialysis (PD) patients...
  42. pmc Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients
    Wendell Vilas-Boas
    Centro de Pesquisas Gonçalo Moniz FIOCRUZ, Rua Waldemar Falcão 121 Brotas, Salvador, Bahia, Brazil
    Ann Hematol 89:877-82. 2010
    ..Additional studies should be carried out in order to investigate the mechanisms by which TGF-beta participates in the metabolism of arginase in SCA patients...
  43. pmc Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis
    Tapan K Mukherjee
    Department of Obstetrics and Gynecology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095 1740, USA
    Proc Natl Acad Sci U S A 99:4055-60. 2002
    ..Results from our study may help explain the mechanism by which testosterone may have beneficial effects on the cardiovascular system...
  44. ncbi Contrasting roles for domain 4 of VCAM-1 in the regulation of cell adhesion and soluble VCAM-1 binding to integrin alpha4beta1
    Darren G Woodside
    Encysive Pharmaceuticals Incorporated, Houston, TX 77030, USA
    J Immunol 176:5041-9. 2006
    ..These results indicate that the domain 4 of VCAM-1 plays a contrasting role when VCAM-1 is presented in solution or as a cell surface-expressed adhesive substrate...
  45. ncbi Levels of soluble vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-2 in plasma of patients with hemorrhagic fever with renal syndrome, and significance of the changes in level
    Bao Tai Qi
    Department of Pathogenic Microbiology and Immunology, Medical School of Xi an Jiaotong University, Xi an, China
    Viral Immunol 19:565-9. 2006
    ..sICAM-2 may be associated with the hyperfunctioning of the cellular immune response...
  46. ncbi The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon
    Hanna Harant
    Novartis Institutes for BioMedical Research, A 1235 Vienna, Austria
    J Biol Chem 281:30492-502. 2006
    ..Our data indicate that the compound inhibits translocation of VCAM1 by interfering with correct insertion of its signal peptide into the translocon...
  47. ncbi Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity
    Hiroshi Ochi
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 32:1821-31. 2002
    ..Thus, pathophysiological fluctuations in plasma osmolarity may influence certain endothelial-dependent components of the inflammatory response and host defense mechanisms...
  48. ncbi L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion
    Yasunori Abe
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin, A679B, Houston, TX 77030, United States
    Atherosclerosis 192:56-66. 2007
    ....
  49. ncbi Serum interleukin-18 levels are increased and closely associated with various soluble adhesion molecule levels in type 1 diabetic patients
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Care 30:159-61. 2007
  50. pmc Tetraspanins CD81 and CD82 facilitate α4β1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1
    Frances A Spring
    Bristol Institute for Transfusion Sciences, Bristol, United Kingdom
    PLoS ONE 8:e62654. 2013
    ..These results strongly suggest that tetraspanins have a functional role in terminal erythropoiesis by modulating interactions of erythroblast α4β1 with both macrophages and extracellular matrix...
  51. pmc Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation
    Yu Ping Zhu
    Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, China
    Acta Pharmacol Sin 34:1036-42. 2013
    ..To investigate the effects Astragalus polysaccharides (APS) on tumor necrosis factor (TNF)-α-induced inflammatory reactions in human umbilical vein endothelial cells (HUVECs) and to elucidate the underlying mechanisms...
  52. ncbi Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus
    Ewa Robak
    Department of Dermatology and Venereology, Medical University of Lodz, Lodz, ul Ciolkowskiego 2, 93 510 Lodz, Poland
    Eur Cytokine Netw 18:181-7. 2007
    ..We found a positive correlation between serum concentrations of PIGF and SLE activity according to SLAM score (p=0.33, p=0.13)...
  53. pmc Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells
    Wenliang Zhang
    Bioactive Lipid Research Program, Wayne State University School of Medicine, Detroit, MI 48202, United States Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48202, United States
    Prostaglandins Other Lipid Mediat 106:62-71. 2013
    ..Collectively, our data suggest that TNFα treatment activates autocrine S1P/S1P2 signaling, which subsequently activates NFκB and leads to the proinflammatory responses in endothelial cells. ..
  54. ncbi Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production
    M Sironi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 84:1913-21. 1994
    ..Interaction of these cytokines with vascular endothelium may play an important role in the induction and expression of Th2-dependent responses...
  55. ncbi Light/dark patterns of soluble vascular cell adhesion molecule-1 in relation to melatonin in patients with ST-segment elevation myocardial infarction
    Alberto Dominguez-Rodriguez
    Department of Cardiology Coronary Care Unit, Hospital Universitario de Canarias, Tenerife, Spain
    J Pineal Res 44:65-9. 2008
    ..05). The results suggest that diurnal variations in endogenous sVCAM-1 production in STEMI patients might be related to an attenuated circadian secretion of melatonin...
  56. doi Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts
    Shue Fen Luo
    Chang Gung University, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan
    Arthritis Rheum 62:105-16. 2010
    ..To investigate the roles of MAPKs and NF-kappaB in tumor necrosis factor alpha (TNFalpha)-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human rheumatoid arthritis synovial fibroblasts (RASFs)...
  57. doi Flavonoids from Citrus unshiu Marc. inhibit cancer cell adhesion to endothelial cells by selective inhibition of VCAM-1
    Hana Jin
    Department of Pharmacology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660 702, Republic of Korea
    Oncol Rep 30:2336-42. 2013
    ....
  58. pmc Alternative splicing of human VCAM-1 in activated vascular endothelium
    M I Cybulsky
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115
    Am J Pathol 138:815-20. 1991
    ..Alternative splicing of the VCAM-1 gene in cytokine-activated endothelium may generate functionally distinct cell-surface adhesion molecules...
  59. doi Increased monocyte adhesion by endothelial expression of VCAM-1 missense variation in vitro
    Boris Schmitz
    University Hospital Munster, Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, Horstmarer Landweg 39, D 48149 Munster, Germany University Hospital Münster, Internal Medicine D, Nephrology, Hypertension and Rheumatology, Munster, Germany
    Atherosclerosis 230:185-90. 2013
    ..In the current work, we investigated the functional impact of VCAM-1 missense variants and their effect on cell-cell adhesion...
  60. pmc Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1
    L Osborn
    Biogen, Inc, Cambridge, Massachusetts 02142
    J Exp Med 176:99-107. 1992
    ..Therefore both sites must be blocked in clinical, animal, or in vitro studies depending on the use of anti-VCAM-1 antibodies to inactivate the VCAM-1/VLA-4 adhesion pathway...
  61. ncbi Modulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 on human coronary smooth muscle cells by cytokines
    M Braun
    Medizinische Klinik, Universitatsklinikum Charite, Humboldt Universitat zu Berlin, Germany
    J Mol Cell Cardiol 27:2571-9. 1995
    ..These results demonstrate that cytokines regulate ICAM-1 and VCAM-1 expression on human coronary and pulmonary smooth muscle cells. These effects may play an important role in the immune mechanisms in atherosclerosis...
  62. ncbi Cellular activation through the ligation of intercellular adhesion molecule-1
    A Clayton
    Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, Cardiff CF2 1SZ, Wales, UK
    J Cell Sci 111:443-53. 1998
    ..This may have profound implications for the control and persistence of a leukocyte infiltrate and the progression of inflammatory disease...
  63. doi Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells
    Ki Hyung Kim
    Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan 602 739, Korea
    Phytother Res 26:1037-47. 2012
    ..These findings suggest that curcumin may have potential therapeutic uses in the prevention and treatment of endometriosis...
  64. ncbi The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1
    M Van der Vieren
    ICOS Corp, Bothell, WA 98021, USA
    J Immunol 163:1984-90. 1999
    ..These results indicate that VCAM-1 can bind to an I domain and that the binding of alpha D beta 2 to VCAM-1 may contribute to the trafficking of a subpopulation of leukocytes that express alpha D beta 2...
  65. doi Urine sVCAM-1 and sICAM-1 levels are elevated in lupus nephritis
    Hwee Siew Howe
    Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore
    Int J Rheum Dis 15:13-6. 2012
    ....
  66. doi The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells
    Erhan Astarci
    Department of Biochemistry, Middle East Technical University, Ankara, Turkey
    FEBS J 279:2966-86. 2012
    ..Thus, regulation of ICAM-1 and VCAM-1, although both NF-κB target genes, appears to be different over the course of epithelial differentiation in Caco-2 cells...
  67. doi Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives
    R V Vince
    Department of Sport, Health and Exercise Science, University of Hull, Hull, UK
    Eur J Appl Physiol 105:507-13. 2009
    ..095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness...
  68. pmc Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells
    D H Ryan
    Department of Pathology, University of Rochester Medical Center, New York 14642
    J Clin Invest 88:995-1004. 1991
    ....
  69. pmc Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients
    Hala El-Mesallamy
    Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt
    Mediators Inflamm 2007:73635. 2007
    ..P-selectin and ICAM-1 were significantly positively correlated. This study indicates that increased level of oxidative stress marker, proinflammatory markers, and their downstream effectors adhesion molecules occur in type 2 DM...
  70. doi Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia
    Carlos J Veas
    Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, P O Box 237, Concepcion, Chile
    J Matern Fetal Neonatal Med 24:1371-7. 2011
    ..To evaluate the association between endothelial activation markers in the maternal circulation with nitric oxide (NO) synthesis in human umbilical endothelial cells...
  71. ncbi Caveolin-1 is associated with VCAM-1 dependent adhesion of gastric cancer cells to endothelial cells
    Jaeyoung Shin
    Department of Molecular Biology and Institute of Nanosensor and Biotechnology, Dankook Univiersity, Seoul, Korea
    Cell Physiol Biochem 17:211-20. 2006
    ....
  72. ncbi Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution
    E Y Jones
    Laboratory of Molecular Biophysics, Oxford Centre for Molecular Sciences, UK
    Nature 373:539-44. 1995
    ..These, and additional data, map VLA-4 binding to the face of the CFG beta-sheet, the surface previously identified as the site for intercellular adhesive interactions between members of the immunoglobulin superfamily...
  73. doi Evidences for correlation between the reduced VCAM-1 expression and hyaluronan synthesis during cellular senescence of human mesenchymal stem cells
    Eun Mi Jung
    Integrative Omics Research Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 404:463-9. 2011
    ..Thus, we suggest that hyaluronan supplementation in expansion culture of MSCs would compensate adverse effects induced by its decreased synthesis and subsequently enhance cell adhesion and migration abilities...
  74. doi Soluble vascular cell adhesion molecule-1 induces human eosinophil migration
    S Ueki
    Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan
    Allergy 64:718-24. 2009
    ..Elevated levels of the soluble forms of adhesion molecules in the body fluid of asthmatic patients have been observed, although their pathophysiological significance remains to be fully elucidated...
  75. ncbi Structure/function studies on vascular cell adhesion molecule-1
    B Pepinsky
    Biogen, Inc, Cambridge, Massachusetts 02142
    J Biol Chem 267:17820-6. 1992
    ....
  76. doi Gastrin induces the interaction between human mononuclear leukocytes and endothelial cells through the endothelial expression of P-selectin and VCAM-1
    Sales Ibiza
    Departamento de Farmacología and CIBERehd, Universidad de Valencia, Spain
    Am J Physiol Cell Physiol 297:C1588-95. 2009
    ..Gastrin induces interactions between human mononuclear leukocytes and endothelial cells through the activation of CCK-2 receptors and the enhancement of endothelial P-selectin and VCAM-1...
  77. ncbi Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts
    Rithwik Ramachandran
    Respiratory Medicine, Division of Academic Medicine, Post Graduate Medical Institute of the University of Hull in association with the Hull York Medical School, East Yorkshire, HU16 5JQ, United Kingdom
    Am J Respir Cell Mol Biol 35:133-41. 2006
    ..PAR2-driven upregulation of VCAM-1 cell surface expression and the release of IL-8 and G-CSF from bronchial fibroblasts may be important in promoting neutrophilic airways inflammation...
  78. pmc P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line
    Olga J Baker
    Department of Biochemistry, University of Missouri Columbia, 540E Christopher S Bond Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211 0001, USA
    Mol Immunol 45:65-75. 2008
    ..These results suggest that P2Y2R activation in salivary gland cells increases the EGFR-dependent expression of VCAM-1 and the binding of lymphocytes, a pathway relevant to inflammation associated with SS...
  79. pmc s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal
    Diana Rubin
    Max Rubner Institut, Federal Research Center of Nutrition and Food, Herrmann Weigmann Str 1, 24103 Kiel, Germany
    Lipids Health Dis 7:32. 2008
    ..We conducted assessment of association between postprandial triglycerides, insulin and glucose after ingestion of a standardized lipid-rich test meal, and soluble cellular adhesion molecules (sCAM) in young healthy subjects...
  80. doi Immunohistochemical analysis of cellular adhesion molecules (ICAM-1, VCAM-1) and VEGF in fibrovascular membranes of patients with proliferative diabetic retinopathy: preliminary study
    T Khalfaoui
    Service d Ophtalmologie, Hopital Charles Nicolle, Boulevard du 9 Avril, Bab Souika, 1006 Tunis, Tunisia
    Pathol Biol (Paris) 57:513-7. 2009
    ..To this end, we analyzed the simultaneous expression of ICAM-1, VCAM-1 and VEGF within tissues of diabetic fibrovascular membranes...
  81. doi Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes
    Ha Yong Song
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Free Radic Biol Med 50:576-84. 2011
    ....
  82. pmc The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1
    Y Taooka
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, California 94143, USA
    J Cell Biol 145:413-20. 1999
    ..These observations suggest a possible role for alpha9beta1/VCAM-1 interactions in extravasation of neutrophils at sites of acute inflammation...
  83. ncbi Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kappaB-dependent pathway
    Alison K Death
    Discipline of Medicine, University of Sydney, New South Wales, Australia
    Endocrinology 145:1889-97. 2004
    ....
  84. pmc HIV-1 gp120 and drugs of abuse: interactions in the central nervous system
    Peter S Silverstein
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Curr HIV Res 10:369-83. 2012
    ..This review will summarize the neurotoxic effects of gp120, the deleterious effects of cocaine, methamphetamine and morphine on the CNS, and the combined effects of gp120 in the context of these drugs...
  85. pmc ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion
    Hailing Li
    Department of Cardiology, Shanghai Tenth People s Hospital, Tongji University, School of Medicine, Shanghai, China
    Cardiovasc Diabetol 11:65. 2012
    ....
  86. ncbi At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products
    Giuseppina Basta
    C N R Institutes of Clinical Physiology, Pisa, Italy
    Arterioscler Thromb Vasc Biol 25:1401-7. 2005
    ..We investigated the role of distinct sources of ROS, including the mitochondrial electron transport chain, NAD(P)H oxidase, xanthine oxidase, and arachidonic acid metabolism, in AGE-induced VCAM-1 expression...
  87. ncbi The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways
    Juliette Fitau
    INSERM, U643, Nantes, France
    J Biol Chem 281:20148-59. 2006
    ..Collectively, our results identify the adaptor Lnk as a negative regulator in the TNFalpha-signaling pathway mediating ERK inhibition and suggest a role for Lnk in the interplay between PI3K and ERK triggered by TNFalpha in ECs...
  88. ncbi VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells
    A L Lazaar
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 166:155-61. 2001
    ..These studies suggest that VCAM-1 is linked to multiple signaling pathways in human ASM cells and may function to augment growth factor-induced responses...
  89. ncbi Alpha 4 beta 1 integrin/VCAM-1 interaction activates alpha L beta 2 integrin-mediated adhesion to ICAM-1 in human T cells
    J R Chan
    Department of Laboratory Medicine, University of Toronto, Toronto General Hospital Research Institute, Toronto, Canada
    J Immunol 164:746-53. 2000
    ..A role for the cytoskeleton is implicated in this process...
  90. ncbi The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1)
    Cheikh I Seye
    Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Biol Chem 279:35679-86. 2004
    ..These data indicate a novel mechanism whereby a nucleotide receptor transactivates a receptor tyrosine kinase to generate an inflammatory response associated with atherosclerosis...
  91. doi Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy
    Mariusz Nowak
    Pathophysiology Division, Department of Pathophysiology and Endocrinology, Medical University of Silesia, 41 800 Zabrze pl, Traugutta 2, Poland
    Clin Exp Med 8:159-64. 2008
    ....
  92. ncbi VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration
    Sandra van Wetering
    Department of Experimental Immunohematology, Sanquin Research at CLB, 1066 CX Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 285:C343-52. 2003
    ..Together, these data indicate that VCAM-1-induced, Rac-dependent signaling plays a key role in the modulation of vascular-endothelial cadherin-mediated endothelial cell-cell adhesion and leukocyte extravasation...
  93. doi Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells
    Rosalinda Madonna
    Institute of Cardiology, Center of Excellence on Aging, G d Annunzio University Chieti, Italy
    Biochim Biophys Acta 1782:511-6. 2008
    ..Therefore, hyperinsulinemia enhances cytokine-induced VCAM-1 expression in endothelial cells, thus potentially contributing to detrimental effects of other inflammatory stimuli on atherogenesis...
  94. ncbi Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
    J P Levesque
    Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 98:1289-97. 2001
    ....
  95. ncbi Testosterone inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells
    Haruhiko Hatakeyama
    Department of Internal Medicine, Division of Endocrinology, Kanazawa Medical University, Ishikawa 920 0293, Japan
    FEBS Lett 530:129-32. 2002
    ..Our results may suggest an inhibitory effect of T on atherogenesis, providing a novel insight into the consideration of the pathogenesis of atherosclerosis...
  96. ncbi Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein
    Martin F Crook
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, UK
    J Vasc Res 39:221-9. 2002
    ..These experiments imply that either integrin might be targeted to reduce monocyte infiltration into HSV grafts...
  97. pmc Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    Olga Barreiro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Cell Biol 157:1233-45. 2002
    ..These results provide the first characterization of an endothelial docking structure that plays a key role in the firm adhesion of leukocytes to the endothelium during inflammation...
  98. ncbi VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation
    Manuela Gavina
    Stem Cell Laboratory, Department of Neurological Sciences, IRCCS, Centro Dino Ferrari, University of Milan, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Blood 108:2857-66. 2006
    ....
  99. ncbi Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis
    Jose Figueras-Aloy
    Servicio Neonatología, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Spain
    Am J Perinatol 24:331-8. 2007
    ..These levels were related to the clinical severity of the disease. Soluble VCAM-1 levels increased only slightly in HC + sepsis. Soluble L-selectin and sP-selectin did not change...
  100. ncbi Gliclazide treatment lowers serum ICAM-1 levels in poorly controlled type 2 diabetic patients
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Diabetes Metab 32:344-9. 2006
    ..To investigate the potential effect of gliclazide on serum ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) levels in poorly controlled type 2 diabetic patients...
  101. ncbi Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells
    Mushtaq Ahmad
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 22:759-64. 2002
    ..Thus, ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway, and it appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1...

Research Grants24

  1. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2010
    ..In the end, this study will aid saving a number of patients who suffer from the ischemic disorders of myocardial and peripheral tissues. ..
  2. In vivo function of macrophage in healthy and diseased erythropoiesis
    Paul S Frenette; Fiscal Year: 2013
    ..These studies will define for the first time the in vivo roles of BM macrophages in erythropoiesis and will likely lead to novel ways to regulate erythropoiesis in diseases characterized by erythron expansion. (End of Abstract) ..
  3. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2013
    ..The proposed study will provide valuable knowledge about the pathophysiology and mechanism by which As exposure may lead to CVD and may also lead to improved prevention and risk assessment of As exposure. ..
  4. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven E Shoelson; Fiscal Year: 2010
    ..The findings will improve our understanding of the role of subacute 'inflammation'in insulin resistance, T2D and the metabolic syndrome, and may identify new and more selective targets for therapeutic intervention. ..
  5. Flow Responsive Mediators of Inflammation and Survival
    Chen Yan; Fiscal Year: 2013
    ..These studies should provide insight into mechanisms by which flow inhibits inflammation and facilitate development of therapeutic approaches to limit atherosclerosis. ..
  6. Biobehavioral Genetics of CVD Risk
    Indrani Halder; Fiscal Year: 2010
    ..The ROO phase will involve examining all genes for a comprehensive evaluation of the pathways (End of Abstract) ..
  7. FOLLICULAR ANTIGEN BINDING DENDRITIC CELLS
    John Tew; Fiscal Year: 2009
    ..in FDC-B cell-T cell interactions including: Ag-Ab complexes, CD21L, CD23, CD32/FcyRIIB, CD40, CD44, CD54/ICAM-1, CD106/VCAM-1, and CD320/8D6;3) Products secreted by FDCs that influence GC reactions include CXCL-12, CXCL-13, and IL-6...
  8. TRANSCRIPTIONAL REGULATION OF VCAM1
    Andrew Neish; Fiscal Year: 2001
    ..Elucidation of the mechanisms of transcription factor interactions will further our knowledge of how VCAM1 induction is regulated and how this important molecule is controlled by a variety of immuno-inflammatory stimuli. ..
  9. PATHWAY OF VENTRICULAR MORPHOGENESIS MEDICATED BY RXRA
    Henry Sucov; Fiscal Year: 2001
    ..abstract_text> ..
  10. Cellular Assay:Presentation of the Adhesion Molecul(RMI)
    Thomas Mayer; Fiscal Year: 2005
    ..The assay can generate data with high confidence and a Z' factor of 0.80. We have also shown that the assay is a powerful tool to screen for bioactive compounds. ..
  11. Hyposialylation Regulates Alpha4Beta1 Integrin Binding to VCAM1
    ALENCIA WOODARD GRICE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. PHASE I/II STUDY OF SIMVASTATIN (ZOCOR) THERAPY IN SICKLE CELL DISEASE
    Carolyn Hoppe; Fiscal Year: 2008
    ..unreadable] [unreadable] 2. To assess the safety and tolerability of oral simvastatin in patients with SCD. [unreadable] [unreadable] [unreadable]..
  13. Genetic Predictors of Comorbid Depressive Symptoms + CAD
    Jeanne McCaffery; Fiscal Year: 2005
    ....
  14. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Such an approach will provide a rational basis for the development of potentially powerful and effective therapeutics for ocular neovascularization. ..
  15. In Vitro Model of the Human Blood Brain Barrier to study
    Monique Stins; Fiscal Year: 2003
    ..By characterizing the individual steps involved in entry of monocytes into the brain, a better understanding of the pathogenesis of HIV-1-1 encephalopathy will be obtained and strategies may be developed to halt this process. ..
  16. MOLECULAR DETERMINANTS OF BRAIN-METASTATIC MELANOMA
    Dario Marchetti; Fiscal Year: 2010
    ..Research outlined here will help in delineating molecular events associated with malignant melanoma growth and brain metastasis, as influenced by enzyme-driven interactions between tumor cells and extracellular matrix ..
  17. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..The hypothesis is that cardiac fibrosis will be regulated by urokinase activity and other functions of PAI-I which will be further pursued in future studies of mice expressing functional mutations of PAI-1. ..
  18. ACYLTRANSFERASE INHIBITORS AS ANTI RAS AGENTS
    Charles Smith; Fiscal Year: 2009
    ..abstract_text> ..
  19. ADHESION MOLECULES IN SMOOTH MUSCLE ACTIVATION & GROWTH
    AILI LAZAAR; Fiscal Year: 2003
    ..Understanding the mechanisms by which CAMs transduce signals that could induce myocyte activation may provide insight in new therapeutic measures to prevent airway inflammation and bronchial hyperreactivity. ..
  20. NOVEL COMPOUNDS WHICH CIRCUMVENT MULTIDRUG RESISTANCE
    Charles Smith; Fiscal Year: 2001
    ..These studies should allow a critical evaluation of the potential utility of these novel compounds as clinical agents. ..
  21. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2005
    ..The primary method of analysis will be twin structural equation modeling. ..
  22. PREVENTIVE/THERAPEUTIC HPV VACCINE DEVELOPMENT
    T C Wu; Fiscal Year: 2003
    ..A.5 Evaluate the mechanisms of the anti-tumor immunity induced by vaccination. ..
  23. ENHANCEMENT OF HPV16 E6 & E7-SPECIFIC ANTITUMOR IMMUNITY
    T C Wu; Fiscal Year: 2001
    ..5) Perform head-to-head comparison of various E6, E7 and chimeric E6E7 vaccines in antitumor immunity using E6 and E7 expressing murine model tumors. ..