Vav

Summary

Gene Symbol: Vav
Description: vav guanine nucleotide exchange factor 1
Alias: VAV, proto-oncogene vav, vav 1 guanine nucleotide exchange factor, vav 1 oncogene
Species: human
Products:     Vav

Top Publications

  1. Hobert O, Jallal B, Schlessinger J, Ullrich A. Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction. J Biol Chem. 1994;269:20225-8 pubmed
  2. Yin J, Wan Y, Li S, Du M, Zhang C, Zhou X, et al. The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells. Acta Pharmacol Sin. 2011;32:99-107 pubmed publisher
    ..Vav1 protects Jurkat cells from Fas-mediated apoptosis by promoting Bcl-2 transcription through its GEF activity. ..
  3. Romero F, Dargemont C, Pozo F, Reeves W, Camonis J, Gisselbrecht S, et al. p95vav associates with the nuclear protein Ku-70. Mol Cell Biol. 1996;16:37-44 pubmed
    The proto-oncogene vav is expressed solely in hematopoietic cells and plays an important role in cell signaling, although little is known about the proteins involved in these pathways...
  4. Yu B, Martins I, Li P, Amarasinghe G, Umetani J, Fernandez Zapico M, et al. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010;140:246-56 pubmed publisher
    b>Vav proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. They control processes including T cell activation, phagocytosis, and migration of normal and transformed cells...
  5. Han J, Luby Phelps K, Das B, Shu X, Xia Y, Mosteller R, et al. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science. 1998;279:558-60 pubmed
    ..b>Vav, a guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange factor for Rac that stimulates the exchange of ..
  6. Ilan L, Katzav S. Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation. PLoS ONE. 2012;7:e29939 pubmed publisher
    ..Mutation of other putative transcription factor binding sites suggests that additional factors regulate vav1 expression as well. ..
  7. Tartare Deckert S, Monthouel M, Charvet C, Foucault I, Van Obberghen E, Bernard A, et al. Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. J Biol Chem. 2001;276:20849-57 pubmed
    ..The negative regulatory pathway elicited by Vav2 might play an important role in regulating lymphocyte activation processes. ..
  8. Jevremovic D, Billadeau D, Schoon R, Dick C, Leibson P. Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2. J Immunol. 2001;166:7219-28 pubmed
    ..Here we describe a positive regulatory role for 3BP2 in NK cell-mediated cytotoxicity. We also identify p95(vav) and phospholipase C-gamma isoforms as binding partners of 3BP2...
  9. Charvet C, Auberger P, Tartare Deckert S, Bernard A, Deckert M. Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway. J Biol Chem. 2002;277:15376-84 pubmed
    The Vav family of guanine nucleotide exchange factors for Rho family GTPases plays a critical role in lymphocyte proliferation, gene transcription, and cytoskeleton reorganization following immunoreceptor stimulation...

More Information

Publications72

  1. Heo J, Thapar R, Campbell S. Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors. Biochemistry. 2005;44:6573-85 pubmed
    b>Vav proteins are Rho GTPase-specific guanine nucleotide exchange factors (GEFs) that are distinguished by the tandem arrangement of Dbl homology (DH), Pleckstrin homology (PH), and cysteine rich domains (CRD)...
  2. Katzav S, Martin Zanca D, Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989;8:2283-90 pubmed
    A novel human oncogene, designated vav, was generated by a genetic rearrangement during gene transfer assays. The vav oncogene directs the synthesis of a 3.0 kb mRNA from which we isolated a 2.8 kb-long complementary DNA copy...
  3. Bartolomé R, Molina Ortiz I, Samaniego R, Sánchez Mateos P, Bustelo X, Teixido J. Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res. 2006;66:248-58 pubmed
    ..Interference with MMP-2 expression further confirms its important role during this invasion. Vav proteins are guanine-nucleotide exchange factors for Rho GTPases that regulate actin dynamics and gene expression...
  4. Zhang W, Sloan Lancaster J, Kitchen J, Trible R, Samelson L. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 1998;92:83-92 pubmed
    ..Its function is demonstrated by inhibition of T cell activation following overexpression of a mutant form lacking critical tyrosine residues. Therefore, we propose to name the molecule LAT-linker for activation of T cells. ..
  5. Zhou Z, Yin J, Dou Z, Tang J, Zhang C, Cao Y. The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. J Biol Chem. 2007;282:23737-44 pubmed
    ..This study unveiled a mechanism by which the Vav1 CH domain is involved in calcium signaling and provides insight into our understanding of the role of Vav1 in T cell activation. ..
  6. Miura Shimura Y, Duan L, Rao N, Reddi A, Shimura H, Rottapel R, et al. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003;278:38495-504 pubmed
    ..Cbl is known to associate with the proto-oncogene product Vav, a hematopoietic-restricted Rac guanine nucleotide exchange factor, but the consequences of this interaction remain ..
  7. Das B, Shu X, Day G, Han J, Krishna U, Falck J, et al. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem. 2000;275:15074-81 pubmed
    b>Vav and Sos1 are Dbl family guanine nucleotide exchange factors, which activate Rho family GTPases in response to phosphatidylinositol 3-kinase products...
  8. Quaranta M, Mattioli B, Spadaro F, Straface E, Giordani L, Ramoni C, et al. HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells. FASEB J. 2003;17:2025-36 pubmed
    ..for molecules involved in Nef-triggered signaling pathways driving the DC maturation, we found that Nef targets Vav and promotes its tyrosine phosphorylation, associated with its nucleus-to-cytoplasm redistribution...
  9. Hofmann T, Hehner S, Droge W, Schmitz M. Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription. Oncogene. 2000;19:1153-63 pubmed
    ..Since Vav1 is essential for IL-2 production and plays a central role for cytoskeletal reorganization, its proteolytic inactivation during apoptosis affects multiple downstream targets. ..
  10. Lopez Lago M, Lee H, Cruz C, Movilla N, Bustelo X. Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. Mol Cell Biol. 2000;20:1678-91 pubmed
    b>Vav works as a GDP/GTP exchange factor for Rac GTPases, thereby facilitating the transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state...
  11. Paccani S, Boncristiano M, Patrussi L, Ulivieri C, Wack A, Valensin S, et al. Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects. Blood. 2005;106:626-34 pubmed
    ..On the other hand, T-CVID T cells show dramatic defects in the Vav/Rac pathway controlling F-actin dynamics...
  12. Lee I, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T. Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6. FEBS Lett. 1997;401:133-7 pubmed
    b>Vav is a hematopoietic cell-specific proto-oncogene. We show that interleukin-6 (IL-6) induces transient tyrosine phosphorylation of Vav in a human myeloma cell line, U266...
  13. Ramos Morales F, Romero F, Schweighoffer F, Bismuth G, Camonis J, Tortolero M, et al. The proline-rich region of Vav binds to Grb2 and Grb3-3. Oncogene. 1995;11:1665-9 pubmed
    b>Vav has structural features found in signaling proteins and is expressed only in hematopoietic cells. The recent development of mice Vav -/- has confirmed a major role of Vav in early blood cell development...
  14. Katzav S, Sutherland M, Packham G, Yi T, Weiss A. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J Biol Chem. 1994;269:32579-85 pubmed
    ..the T cell antigen receptor (TCR) leads to tyrosine phosphorylation of a number of cellular proteins, including the vav proto-oncogene product...
  15. Crespo P, Schuebel K, Ostrom A, Gutkind J, Bustelo X. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 1997;385:169-72 pubmed
    The oncogenic protein Vav harbours a complex array of structural motifs, including leucine-rich, Dbl-homology, pleckstrin-homology, zinc-finger, SH2 and SH3 domains...
  16. Ye Z, Baltimore D. Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc Natl Acad Sci U S A. 1994;91:12629-33 pubmed
    The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation...
  17. Rauch S, Pulkkinen K, Saksela K, Fackler O. Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity. J Virol. 2008;82:2918-29 pubmed
    ..Previous studies suggested the association of Nef with at least three independent GEFs, Vav, DOCK2/ELMO1, and betaPix...
  18. Katzav S, Cleveland J, Heslop H, Pulido D. Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential. Mol Cell Biol. 1991;11:1912-20 pubmed
    b>vav, a novel human oncogene, was originally generated in vitro by replacement of its normal 5' coding sequences with sequences from pSV2neo DNA, cotransfected as a selectable marker (S. Katzav, D. Martin-Zanca, and M. Barbacid, EMBO J...
  19. Houlard M, Romero Portillo F, Germani A, Depaux A, Regnier Ricard F, Gisselbrecht S, et al. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. Oncogene. 2005;24:28-38 pubmed
    Binding partners of the Src homology domains of Vav-1 were characterized by a two-hybrid screening of a Jurkat cell cDNA library...
  20. Razidlo G, Schroeder B, Chen J, Billadeau D, McNiven M. Vav1 as a central regulator of invadopodia assembly. Curr Biol. 2014;24:86-93 pubmed publisher
  21. Groysman M, Hornstein I, Alcover A, Katzav S. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. J Biol Chem. 2002;277:50121-30 pubmed
    ..Thus, our data suggest that the interaction of Vav1 and Ly-GDI creates a fine tuning mechanism for the regulation of intracellular signaling pathways leading to NFAT stimulation. ..
  22. Cao Y, Janssen E, Duncan A, Altman A, Billadeau D, Abraham R. Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J. 2002;21:4809-19 pubmed
    The Rac/Rho-specific guanine nucleotide exchange factor, Vav-1, is a key component of the T-cell antigen receptor (TCR)-linked signaling machinery...
  23. Tuosto L, Marinari B, Piccolella E. CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage. J Immunol. 2002;168:6106-12 pubmed
    ..Furthermore, we demonstrate that Leu3a treatment of Jurkat cells overexpressing Vav results in the inhibition of mitochondrial damage and apoptosis; this rescue effect is accompanied with a ..
  24. Razidlo G, Wang Y, Chen J, Krueger E, Billadeau D, McNiven M. Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Dev Cell. 2013;24:573-85 pubmed publisher
    ..These findings elucidate how Dyn2 activates Rac1, lamellipod protrusion, and invasive cellular migration and provide insight into how this specific Vav is ectopically expressed in pancreatic tumors.
  25. Brooun A, Foster S, Chrencik J, Chien E, Kolatkar A, Streiff M, et al. Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex. Protein Expr Purif. 2007;53:51-62 pubmed
  26. Sebban S, Farago M, Gashai D, Ilan L, Pikarsky E, Ben Porath I, et al. Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer. PLoS ONE. 2013;8:e54321 pubmed publisher
    ..These results highlight for the first time the potential role of Vav1 as an oncogenic stress activator in cancer and the p53 dependence of its pro-apoptotic effect in breast cells. ..
  27. Hobert O, Schilling J, Beckerle M, Ullrich A, Jallal B. SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene. 1996;12:1577-81 pubmed
    ..We present evidence that the product of the vav proto-oncogene, p95vav, interacts specifically with the focal adhesion protein zyxin both in vitro and in yeast two ..
  28. Moores S, Selfors L, Fredericks J, Breit T, Fujikawa K, Alt F, et al. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000;20:6364-73 pubmed
    b>Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations...
  29. Wu J, Motto D, Koretzky G, Weiss A. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 1996;4:593-602 pubmed
    ..TCR) stimulation induces tyrosine phosphorylation of many intracellular proteins, including the proto-oncogene Vav, which is expressed exclusively in hematopoietic and trophoblast cells...
  30. Bustelo X. Regulatory and signaling properties of the Vav family. Mol Cell Biol. 2000;20:1461-77 pubmed
  31. Katzav S. Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Cancer Lett. 2007;255:241-54 pubmed
    ..This review addresses the physiological function of wild-type Vav1, its mode of activation as an oncogene, and its emerging role as a transforming protein in human cancer. ..
  32. Fang N, Koretzky G. SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity. J Biol Chem. 1999;274:16206-12 pubmed
    SLP-76 and Vav, two hematopoietic cell specific molecules, are critical for T cell development and activation...
  33. Li S, Du M, Wan Y, Lan B, Liu Y, Yang Y, et al. The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling. J Biol Chem. 2013;288:3777-85 pubmed publisher
    ..The other highly conserved isoforms of Vav family, Vav2 and Vav3, are ubiquitously expressed in human tissues including lymphocytes...
  34. Coppola J, Bryant S, Koda T, Conway D, Barbacid M. Mechanism of activation of the vav protooncogene. Cell Growth Differ. 1991;2:95-105 pubmed
    b>vav is a human locus that appears to be specifically expressed in cells of hematopoietic origin regardless of their differentiation lineage...
  35. Brugnoli F, Lambertini E, Varin Blank N, Piva R, Marchisio M, Grassilli S, et al. Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation. Exp Cell Res. 2010;316:38-47 pubmed publisher
    ..1 to its consensus sequence on the CD11b promoter and, ultimately, in regulating CD11b expression during the late stages of neutrophil differentiation of APL-derived promyelocytes. ..
  36. Fernandez Zapico M, Gonzalez Paz N, Weiss E, Savoy D, Molina J, Fonseca R, et al. Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell. 2005;7:39-49 pubmed
    ..Thus, the discovery of prooncogenic pathways regulated by Vav1 makes it an attractive target for therapeutic intervention. ..
  37. Greenway A, Holloway G, McPhee D, Ellis P, Cornall A, Lidman M. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. J Biosci. 2003;28:323-35 pubmed
  38. Song J, Gomez J, Stancato L, Rivera J. Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex. J Biol Chem. 1996;271:26962-70 pubmed
    ..on the mucosal mast cell line, RBL-2H3, results in the rapid and persistent tyrosine phosphorylation of Vav. Immunoprecipitation of Vav from activated cells revealed co-immunoprecipitated phosphoproteins of molecular ..
  39. Deckert M, Tartare Deckert S, Couture C, Mustelin T, Altman A. Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity. 1996;5:591-604 pubmed
    ..Here, we report that Syk interacts in the yeast two-hybrid system with Vav, a proto-oncogene product exclusively expressed in hematopoietic cells...
  40. Han J, Das B, Wei W, Van Aelst L, Mosteller R, Khosravi Far R, et al. Lck regulates Vav activation of members of the Rho family of GTPases. Mol Cell Biol. 1997;17:1346-53 pubmed
    b>Vav is a member of a family of oncogene proteins that share an approximately 250-amino-acid motif called a Dbl homology domain...
  41. Fackler O, Luo W, Geyer M, Alberts A, Peterlin B. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell. 1999;3:729-39 pubmed
    ..We identified the protooncogene and guanine nucleotide exchange factor Vav as the specific binding partner of Nef proteins from HIV-1 and SIV...
  42. Marengere L, Mirtsos C, Kozieradzki I, Veillette A, Mak T, Penninger J. Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. J Immunol. 1997;159:70-6 pubmed
    ..The SH2/SH3-containing protein Vav also contains a guanine nucleotide exchange factor domain, and Vav has a crucial role in thymocyte development and ..
  43. Raab M, da Silva A, Findell P, Rudd C. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity. 1997;6:155-64 pubmed
    T cell activation stimulates p56(lck), p59(fyn), ZAP-70, Vav-SLP-76 binding, and IL-2 transcription. Major questions concern the tyrosine-kinase and relevant site(s) needed for Vav-SLP-76 complex formation and its role in IL-2 production...
  44. Gomez T, Hamann M, McCarney S, Savoy D, Lubking C, Heldebrant M, et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol. 2005;6:261-70 pubmed
    ..These data identify a functionally important interaction between Dyn2 and Vav1 that regulates actin reorganization and multiple signaling pathways in T lymphocytes. ..
  45. Ip J, Lerman B. Validation of device algorithm to differentiate pacemaker-mediated tachycardia from tachycardia due to atrial tracking. Heart Rhythm. 2016;13:1612-7 pubmed publisher
    ..The VAV response following postventricular atrial refractory period extension, which is specific to tracking of atrial or ..
  46. Helou Y, Petrashen A, Salomon A. Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28. J Proteome Res. 2015;14:2963-75 pubmed publisher
    ..Our study also uncovered a previously unappreciated role for Vav1 in crosstalk between the CD28 and TCR signaling pathways. ..
  47. Guezguez A, Prod homme V, Mouska X, Baudot A, Blin Wakkach C, Rottapel R, et al. 3BP2 adapter protein is required for receptor activator of NF?B ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells. J Biol Chem. 2010;285:20952-63 pubmed publisher
    ..Importantly, 3BP2 interacted with Src, Syk, Vav, and Cbl in monocytic cells, and the introduction of constitutively active mutants of Src and NFATc1 in 3BP2-..
  48. Chrencik J, Brooun A, Zhang H, Mathews I, Hura G, Foster S, et al. Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol. 2008;380:828-43 pubmed publisher
    ..CRD is critical for maintaining both optimal guanine nucleotide exchange activity and broader specificity of Vav family GEFs...
  49. Bertagnolo V, Marchisio M, Brugnoli F, Bavelloni A, Boccafogli L, Colamussi M, et al. Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells. Cell Growth Differ. 2001;12:193-200 pubmed
    Our previous data demonstrated that cellular and nuclear tyrosine-phosphorylated Vav associate with phosphoinositide 3-kinase during all-trans-retinoic acid-dependent granulocytic differentiation of HL-60 cells...
  50. Bertagnolo V, Nika E, Brugnoli F, Bonora M, Grassilli S, Pinton P, et al. Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells. Cell Tissue Res. 2011;345:163-75 pubmed publisher
  51. DHARMAWARDHANE S, Hernandez E, Vlaar C. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013;33 Pt A:117-46 pubmed publisher
    ..EHop-016 was identified as a compound that blocks the interaction of Rac with the GEF Vav in metastatic human breast cancer cells with an IC50 of ~1?M...
  52. Gelkop S, Gish G, Babichev Y, Pawson T, Isakov N. T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315. J Immunol. 2005;175:8123-32 pubmed
    ..Previous studies demonstrated the Tyr315 is the Vav-Src homology 2 (SH2) binding site, and that replacement of Tyr315 by Phe impaired the function of Zap70 in TCR ..
  53. Lima T, Neves C, Zambelli V, Lopes F, Sampaio S, Cirillo M. Crotoxin, a rattlesnake toxin, down-modulates functions of bone marrow neutrophils and impairs the Syk-GTPase pathway. Toxicon. 2017;136:44-55 pubmed publisher
  54. Mesecke S, Urlaub D, Busch H, Eils R, Watzl C. Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells. Sci Signal. 2011;4:ra36 pubmed publisher
    ..Our data support a central role for Vav1 in determining the cytotoxic activity of NK cells and provide insight into the molecular mechanism of the integration of positive and negative signals during lymphocyte activation. ..
  55. Le Bras S, Moon C, Foucault I, Breittmayer J, Deckert M. Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55. FEBS Lett. 2007;581:967-74 pubmed
    ..Together, our data suggest an unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55. ..
  56. Han J, Das B, Broek D. In vitro, Vav is a regulated guanine nucleotide dissociation inhibitor for Ras. Immunol Lett. 2002;80:1-2 pubmed
  57. Stolp B, Fackler O. How HIV takes advantage of the cytoskeleton in entry and replication. Viruses. 2011;3:293-311 pubmed publisher
  58. Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects. Curr HIV Res. 2006;4:57-64 pubmed
    ..These in vitro and in vivo studies have led to a better understanding of Nef's mechanism of action, although there still exists discord as to the contribution of Nef-mediated disturbance of thymopoiesis in the pathogenesis of AIDS. ..
  59. Gulbins E, Schlottmann K, Brenner B, Lang F, Coggeshall K. Molecular analysis of Ras activation by tyrosine phosphorylated Vav. Biochem Biophys Res Commun. 1995;217:876-85 pubmed
    b>Vav has been shown to activate Ras (1-3) and is regulated by tyrosine phosphorylation (1) or binding of diglycerides (3) to the cysteine rich domain...
  60. Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, et al. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. Genomics. 1993;15:133-45 pubmed
    ..FISH mapping of these cosmids sublocalizes a total of 70 genes and DNA markers on chromosome 19, revises the previously published map assignments of 2 genes, and narrows the location of over 20 markers. ..
  61. Bassermann F, Jahn T, Miething C, Seipel P, Bai R, Coutinho S, et al. Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway. J Biol Chem. 2002;277:12437-45 pubmed
    b>Vav is a guanine nucleotide exchange factor for the Rho/Rac family predominantly expressed in hematopoietic cells and implicated in cell proliferation and cytoskeletal organization...
  62. Uddin S, Katzav S, White M, Platanias L. Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin. J Biol Chem. 1995;270:7712-6 pubmed
    ..One possible mediator in such signaling is the vav proto-oncogene product (p95vav), which is specifically expressed in cells of hematopoietic origin and contains ..
  63. Patrussi L, Savino M, Pellegrini M, Paccani S, Migliaccio E, Plyte S, et al. Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival. Oncogene. 2005;24:2218-28 pubmed
    ..The data underline a pleiotropic and nonredundant role of Shc, mediated by both YY239/240 and Y317, in T-cell activation and survival. ..