Gene Symbol: VAPB
Description: VAMP associated protein B and C
Alias: ALS8, VAMP-B, VAP-B, vesicle-associated membrane protein-associated protein B/C, VAMP (vesicle-associated membrane protein)-associated protein B and C, VAMP-associated 33 kDa protein
Species: human
Products:     VAPB

Top Publications

  1. Nishimura Y, Hayashi M, Inada H, Tanaka T. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. Biochem Biophys Res Commun. 1999;254:21-6 pubmed
    ..hVAP-B had VAMP-binding ability. Moreover, hVAP-A and hVAP-B associated with each other through their respective TMDs. These results suggest that complex formation by VAPs might be important in the trafficking of mammalian vesicle. ..
  2. Marques V, Marques W. Neurophysiological findings of the late-onset, dominant, proximal spinal muscular atrophies with dysautonomia because of the VAPB PRO56SER mutation. J Clin Neurophysiol. 2008;25:233-5 pubmed publisher
    The vesicle-associated membrane protein/synaptobrevin-associated membrane protein B (VAPB) Pro56Ser mutation has been identified in Brazilian families showing various motor neuron syndromes...
  3. Nachreiner T, Esser M, Tenten V, Troost D, Weis J, Kruttgen A. Novel splice variants of the amyotrophic lateral sclerosis-associated gene VAPB expressed in human tissues. Biochem Biophys Res Commun. 2010;394:703-8 pubmed publisher
    ..The P56S missense mutation of the VAPB protein is linked to a hereditary form of amyotrophic lateral sclerosis (ALS8), and the pathogenesis of ALS8 has remained enigmatic...
  4. Prosser D, Tran D, Gougeon P, Verly C, Ngsee J. FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation. J Cell Sci. 2008;121:3052-61 pubmed publisher
    ..The P56S mutation of the B isoform (VAPB) has been linked to late-onset amyotrophic lateral sclerosis (ALS8) and its expression causes formation of large ER ..
  5. Anagnostou G, Akbar M, Paul P, Angelinetta C, Steiner T, de Belleroche J. Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord. Neurobiol Aging. 2010;31:969-85 pubmed publisher
    ..The expression of superoxide dismutase 1 (SOD1), vesicle associated membrane protein (VAPB), senataxin (SETX), dynactin (DCTN1), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF1)..
  6. Nishimura A, Mitne Neto M, Silva H, Richieri Costa A, Middleton S, Cascio D, et al. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am J Hum Genet. 2004;75:822-31 pubmed
    ..a novel missense mutation in the vesicle-associated membrane protein/synaptobrevin-associated membrane protein B (VAPB) gene in patients from this family...
  7. De Vos K, Mórotz G, Stoica R, Tudor E, Lau K, Ackerley S, et al. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet. 2012;21:1299-311 pubmed publisher
    ..serine substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB) causes some dominantly inherited familial forms of motor neuron disease including amyotrophic lateral sclerosis (..
  8. Perry R, Ridgway N. Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. Mol Biol Cell. 2006;17:2604-16 pubmed
    ..Regulation of CERT by OSBP, sterols, and VAP reveals a novel mechanism for integrating sterol regulatory signals with ceramide transport and SM synthesis in the Golgi apparatus. ..
  9. Langou K, Moumen A, Pellegrino C, Aebischer J, Medina I, Aebischer P, et al. AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway. J Neurochem. 2010;114:795-809 pubmed publisher
    A dominant mutation in the gene coding for the vesicle-associated membrane protein-associated protein B (VAPB) was associated with amyotrophic lateral sclerosis, a fatal paralytic disorder characterized by the selective loss of ..

More Information


  1. Mitne Neto M, Machado Costa M, Marchetto M, Bengtson M, Joazeiro C, Tsuda H, et al. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum Mol Genet. 2011;20:3642-52 pubmed publisher
    ..and ALS8 is an autosomal dominant form of familial ALS caused by mutations in the vamp-associated protein B/C (VAPB) gene...
  2. Saita S, Shirane M, Natume T, Iemura S, Nakayama K. Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. J Biol Chem. 2009;284:13766-77 pubmed publisher
    ..These results suggest that VAP-A is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth. ..
  3. Lua S, Qin H, Lim L, Shi J, Gupta G, Song J. Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations. PLoS ONE. 2011;6:e27072 pubmed publisher
  4. Chai A, Withers J, Koh Y, Parry K, Bao H, Zhang B, et al. hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction. Hum Mol Genet. 2008;17:266-80 pubmed
    ..These findings pinpoint to a possible role of hVAPB in synaptic homeostasis and emphasize the relevance of our fly model in elucidating the patho-physiology underlying motor neuron degeneration in humans. ..
  5. Kirby J, Hewamadduma C, Hartley J, Nixon H, Evans H, Wadhwa R, et al. Mutations in VAPB are not associated with sporadic ALS. Neurology. 2007;68:1951-3 pubmed
  6. Chen H, Anagnostou G, Chai A, Withers J, Morris A, Adhikaree J, et al. Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis. J Biol Chem. 2010;285:40266-81 pubmed publisher
    ..ALS (FALS) kindred, a point mutation was identified in vesicle-associated membrane protein-associated protein B (VAPB), or VAMP-associated protein B, causing an amino acid change from threonine to isoleucine at codon 46 (T46I) in one ..
  7. Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, et al. Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. J Virol. 2005;79:13473-82 pubmed
    ..These results suggest that VAP-B, in addition to VAP-A, plays an important role in the replication of the HCV genome. ..
  8. Mórotz G, De Vos K, Vagnoni A, Ackerley S, Shaw C, Miller C. Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Hum Mol Genet. 2012;21:1979-88 pubmed publisher
    ..substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB; VAPBP56S) causes some dominantly inherited familial forms of motor neuron disease, including amyotrophic lateral ..
  9. Nishimura A, Mitne Neto M, Silva H, Oliveira J, Vainzof M, Zatz M. A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13. J Med Genet. 2004;41:315-20 pubmed
  10. Moumen A, Virard I, Raoul C. Accumulation of wildtype and ALS-linked mutated VAPB impairs activity of the proteasome. PLoS ONE. 2011;6:e26066 pubmed publisher
    ..Mutations in the ER-resident protein VAPB have been associated with familial forms of the disease...
  11. Kanekura K, Nishimoto I, Aiso S, Matsuoka M. Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8). J Biol Chem. 2006;281:30223-33 pubmed
    ..We thus speculate that the malfunction of VAPB to mediate UPR, caused by the P56S mutation, may contribute to the development of motoneuronal degeneration linked to VAPB/ALS8.
  12. Kim S, Leal S, Ben Halevy D, Gomes C, Lev S. Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity. J Biol Chem. 2010;285:13839-49 pubmed publisher
    ..These results shed light on the mechanism by which VAP-B(P56S) aggregates are formed and induce familial motor neuron diseases. ..
  13. Kawano M, Kumagai K, Nishijima M, Hanada K. Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT. J Biol Chem. 2006;281:30279-88 pubmed
    ..These results suggest that the Golgi-targeting PH domain and ER-interacting FFAT motif of CERT spatially restrict the random ceramide transfer activity of the START domain in cells. ..
  14. Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, et al. SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations. J Med Genet. 2010;47:554-60 pubmed publisher
    Mutations in SOD1, ANG, VAPB, TARDBP and FUS genes have been identified in amyotrophic lateral sclerosis (ALS)...
  15. Tsuda H, Han S, Yang Y, Tong C, Lin Y, Mohan K, et al. The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell. 2008;133:963-77 pubmed publisher
    VAP proteins (human VAPB/ALS8, Drosophila VAP33, and C. elegans VPR-1) are homologous proteins with an amino-terminal major sperm protein (MSP) domain and a transmembrane domain. The MSP domain is named for its similarity to the C...
  16. Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz M, Akhmanova A, et al. Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates. J Neurosci. 2007;27:9801-15 pubmed
    The vesicle-associated membrane protein-associated proteins (VAPs) VAPA and VAPB interact with lipid-binding proteins carrying a short motif containing two phenylalanines in an acidic tract (FFAT motif) and targets them to the cytosolic ..
  17. Landers J, Leclerc A, Shi L, Virkud A, Cho T, Maxwell M, et al. New VAPB deletion variant and exclusion of VAPB mutations in familial ALS. Neurology. 2008;70:1179-85 pubmed publisher
    ..The vesicle-associated membrane protein B (VAPB) gene has been genetically linked to ALS in several large Brazilian families in which the disorder is caused by a ..
  18. Amarilio R, Ramachandran S, Sabanay H, Lev S. Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. J Biol Chem. 2005;280:5934-44 pubmed
    ..These results demonstrate new mechanisms for the regulation of ER structure, all of which are mediated through interaction with an identical integral ER-membrane protein. ..
  19. Shi J, Lua S, Tong J, Song J. Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis. Biochemistry. 2010;49:3887-97 pubmed publisher
    The Pro56Ser mutation in the human VAPB MSP domain causes a familial amyotrophic lateral sclerosis. Here we present the first structural investigation of both wild-type and Pro56Ser mutant MSP domains...
  20. Mitne Neto M, Ramos C, Pimenta D, Luz J, Nishimura A, Gonzales F, et al. A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins. Protein Expr Purif. 2007;55:139-46 pubmed
    ..Ten loci linked to Familial ALS have been mapped. ALS8 is caused by a substitution of a proline by a serine in the Vesicle-Associated Membrane Protein-Associated protein-..
  21. Fasana E, Fossati M, Ruggiano A, Brambillasca S, Hoogenraad C, Navone F, et al. A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum. FASEB J. 2010;24:1419-30 pubmed publisher
    b>VAPB (vesicle-associated membrane protein-associated protein B) is an endoplasmic reticulum (ER)-resident tail-anchored adaptor protein involved in lipid transport...
  22. Conforti F, Sprovieri T, Mazzei R, Ungaro C, Tessitore A, Tedeschi G, et al. Sporadic ALS is not associated with VAPB gene mutations in Southern Italy. J Negat Results Biomed. 2006;5:7 pubmed
    ..The recent finding of a mutation in the VAMP/synaptobrevin-associated membrane protein B (VAPB) gene as the cause of amyotrophic lateral sclerosis (ALS8), prompted us to investigate the entire coding region of ..
  23. Funke A, Esser M, Kruttgen A, Weis J, Mitne Neto M, Lazar M, et al. The p.P56S mutation in the VAPB gene is not due to a single founder: the first European case. Clin Genet. 2010;77:302-3 pubmed publisher
  24. Genevini P, Papiani G, Ruggiano A, Cantoni L, Navone F, Borgese N. Amyotrophic lateral sclerosis-linked mutant VAPB inclusions do not interfere with protein degradation pathways or intracellular transport in a cultured cell model. PLoS ONE. 2014;9:e113416 pubmed publisher
    ..Its mutant form, P56S-VAPB, which has been linked to a dominantly inherited form of Amyotrophic Lateral Sclerosis (ALS8), generates intracellular inclusions consisting in restructured ER domains whose role in ALS pathogenesis has not ..
  25. Bastepe M, Pincus J, Juppner H. Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13. Mol Cell Probes. 1999;13:449-51 pubmed
  26. Song Q, Li Z, Chen R, Ma X, Xiao X, Xu J. Induction of a Toxin-Antitoxin Gene Cassette under High Hydrostatic Pressure Enables Markerless Gene Disruption in the Hyperthermophilic Archaeon Pyrococcus yayanosii. Appl Environ Microbiol. 2019;85: pubmed publisher
    ..VapC}]) controlled by the HHP-inducible promoter was used in conjunction with the gene encoding antitoxin PF0775 (VapB), which was fused to a constitutive promoter (P hmtB ), and (ii) a positive marker with the 3-..
  27. Zhao Y, Liu N, Miao G, Chen Y, Zhao H, Zhang H. The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis. Curr Biol. 2018;28:1234-1245.e4 pubmed publisher
    ..The integral ER proteins VAPA and VAPB (VAPs) participate in establishing ER contacts with multiple membranes by interacting with different tethers...
  28. Sun Y, Dong Y, Wang J, Lu J, Chen Y, Wu J. A novel mutation of VAPB in one Chinese familial amyotrophic lateral sclerosis pedigree and its clinical characteristics. J Neurol. 2017;264:2387-2393 pubmed publisher
    The mutation of vesicle-associated membrane protein-associated protein B (VAPB) was proved to cause family amyotrophic lateral sclerosis (FALS). Only two mutations of VAPB associated with ALS have been reported (p.Pro56Ser and p.Thr46Ile)...
  29. Costello J, Castro I, Hacker C, Schrader T, Metz J, Zeuschner D, et al. ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. J Cell Biol. 2017;216:331-342 pubmed publisher
    ..ACBD5) as a binding partner for the resident ER protein vesicle-associated membrane protein-associated protein B (VAPB). We show that ACBD5-VAPB interaction regulates PO-ER associations...
  30. Brobeil A, Viard M, Petri M, Steger K, Tag C, Wimmer M. Memory and PTPIP51--a new protein in hippocampus and cerebellum. Mol Cell Neurosci. 2015;64:61-73 pubmed publisher
    ..In hippocampal cells a strong interaction with PTP1B and vesicle-associated membrane protein-associated protein B (VAPB) was detected...
  31. Walling L, Butler J. Structural Determinants for Antitoxin Identity and Insulation of Cross Talk between Homologous Toxin-Antitoxin Systems. J Bacteriol. 2016;198:3287-3295 pubmed
    ..We characterized the specificity determinants of the interactions between VapB antitoxins and VapC toxins from nontypeable Haemophilus influenzae (NTHi) in an effort to gain a better ..
  32. Witkowski L, Rzewuska M, Takai S, Kizerwetter Świda M, Kita J. Molecular epidemiology of Rhodococcus equi in slaughtered swine, cattle and horses in Poland. BMC Microbiol. 2016;16:98 pubmed publisher
    ..equi was detected. All bovine and most of swine isolates (98.1 %) were vapB-positive. 87.9 % of swine isolates carried 95-kb type 5 plasmid, 3...
  33. Vrebalov Cindro P, Vrebalov Cindro V. Genetic determination of motor neuron disease and neuropathy. Coll Antropol. 2015;39:261-5 pubmed
    ..g. SOD1, ALS2, SETX, FUS, VAPB, ANG, TARDBP and others), but many of the forms have still not been associated with a particular gene...
  34. Kukihara H, Moriishi K, Taguwa S, Tani H, Abe T, Mori Y, et al. Human VAP-C negatively regulates hepatitis C virus propagation. J Virol. 2009;83:7959-69 pubmed publisher
    ..These results suggest that VAP-C acts as a negative regulator of HCV propagation and that the expression of VAP-C may participate in the determination of tissue tropism of HCV propagation. ..
  35. McCune B, Tang W, Lu J, Eaglesham J, Thorne L, Mayer A, et al. Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine-Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1/2. MBio. 2017;8: pubmed publisher
    ..Here we report decreased murine norovirus replication in VAPA- and VAPB-deficient cells. We characterized the role of VAPA in detail...
  36. Tran D, Chalhoub A, Schooley A, Zhang W, Ngsee J. A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect. J Cell Sci. 2012;125:2831-6 pubmed publisher
    A proline to serine mutation (P56S) in vesicle-associated membrane protein-associated protein B and C (VAPB) causes an autosomal dominant form of amyotrophic lateral sclerosis (ALS)...
  37. Wilhelm L, Tomasetto C, Alpy F. Touché! STARD3 and STARD3NL tether the ER to endosomes. Biochem Soc Trans. 2016;44:493-8 pubmed publisher
    ..This direct interaction allows ER-endosome contact formation. STARD3 or STARD3NL-mediated ER-endosome contacts, which affect endosome dynamics, are believed to be involved in cholesterol transport. ..
  38. Kabashi E, El Oussini H, Bercier V, Gros Louis F, Valdmanis P, McDearmid J, et al. Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis. Hum Mol Genet. 2013;22:2350-60 pubmed publisher
    ..P56S and T46I in the gene encoding vesicle-associated membrane protein-associated protein B/C (VAPB) cause ALS8, a familial form of amyotrophic lateral sclerosis (ALS)...
  39. Tulli G, Messori A, Trippoli S, Marinai C. Non-inferiority of colistin compared with standard care for the treatment of ventilator-associated pneumonia. Int J Antimicrob Agents. 2017;49:638-641 pubmed publisher
    ..895). This margin was considered to be acceptable on clinical grounds. This analysis found that colistin can play a role in the treatment of VAP, particularly when given as a combination of aerosolized and intravenous drug. ..
  40. Cottee P, Cole T, Schultz J, Hoang H, Vibbert J, Han S, et al. The C. elegans VAPB homolog VPR-1 is a permissive signal for gonad development. Development. 2017;144:2187-2199 pubmed publisher
    ..These results support the model that the secreted VPR-1 MSPd acts at least in part on gonadal sheath cell precursors in L1 to early L2 stage hermaphrodites to permit gonadogenesis. ..
  41. Huttlin E, Ting L, Bruckner R, Gebreab F, Gygi M, Szpyt J, et al. The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015;162:425-440 pubmed publisher
    ..For example, mutations in the membrane protein VAPB implicated in familial amyotrophic lateral sclerosis perturb a defined community of interactors.
  42. Nakamichi S, Yamanaka K, Suzuki M, Watanabe T, Kagiwada S. Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis-associated VAPB(P56S). Biochem Biophys Res Commun. 2011;404:605-9 pubmed publisher
    A human isoform of the vesicle-associated membrane protein-associated proteins (VAPs), VAPB, causes amyotrophic lateral sclerosis eight due to the missense mutation of Pro-56, whereas human VAPA and the yeast VAP Scs2p proteins are not ..
  43. Kosac V, Freitas M, Prado F, Nascimento O, Bittar C. Familial adult spinal muscular atrophy associated with the VAPB gene: report of 42 cases in Brazil. Arq Neuropsiquiatr. 2013;71:788-90 pubmed publisher
    ..Familial spinal muscular atrophy (FSMA) associated with the vesicle-associated membrane protein-associated protein B (VAPB) gene is a rare autosomal dominant disease with late onset and slow progression...
  44. Taguwa S, Okamoto T, Abe T, Mori Y, Suzuki T, Moriishi K, et al. Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication. J Virol. 2008;82:2631-41 pubmed
    ..These results suggest that hB-ind1 plays a crucial role in HCV RNA replication and the propagation of JFH1 virus through interaction with viral and host proteins. ..
  45. Rao M, Song W, Jiang A, Shyr Y, Lev S, Greenstein D, et al. VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity. PLoS ONE. 2012;7:e46281 pubmed publisher
    b>VAPB (VAMP- associated protein B) is an ER protein that regulates multiple biological functions. Although aberrant expression of VAPB is associated with breast cancer, its function in tumor cells is poorly understood...
  46. Tokutake Y, Yamada K, Ohata M, Obayashi Y, Tsuchiya M, Yonekura S. ALS-Linked P56S-VAPB Mutation Impairs the Formation of Multinuclear Myotube in C2C12 Cells. Int J Mol Sci. 2015;16:18628-41 pubmed publisher, we investigated the effects of ALS-associated P56S-vesicle-associated membrane protein-associated protein B (VAPB) (P56S-VAPB) on the IRE1-XBP1 pathway, which is involved in the unfolded protein response (UPR) of the mouse ..
  47. de Morais A, Bolaños C, Alves A, Ikuta C, Lara G, Heinemann M, et al. Identification of Mycobacterium species and Rhodococcus equi in peccary lymph nodes. Trop Anim Health Prod. 2018;50:1319-1326 pubmed publisher
    Mycobacterium species and the virulence-associated proteins (vapA, vapB, and vapN genes) of Rhodococcus equi isolated from 330 lymph nodes of collared peccaries (Tayassu tajacu) and white-lipped peccaries (Tayassu pecari) intended for ..
  48. Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K, et al. Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. J Biol Chem. 2008;283:6584-93 pubmed publisher
    ..These results suggest that CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus. ..
  49. Kuijpers M, Yu K, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad C. The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites. EMBO J. 2013;32:2056-72 pubmed publisher
    The vesicle-associated membrane protein (VAMP) associated protein B (VAPB) is an integral membrane protein localized to the endoplasmic reticulum (ER)...
  50. Tokutake Y, Gushima K, Miyazaki H, Shimosato T, Yonekura S. ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation. Biochem Biophys Res Commun. 2015;460:831-7 pubmed publisher, we investigated the effects of ALS-associated P56S-vesicle-associated membrane proteinassociated protein B (VAPB), P56S-VAPB on 3T3-L1 preadipocyte differentiation and on the expression of differentiation-associated genes and ..
  51. Nakashima Y, Miyagi Shiohira C, Kobayashi N, Saitoh I, Watanabe M, Noguchi H. A proteome analysis of pig pancreatic islets and exocrine tissue by liquid chromatography with tandem mass spectrometry. Islets. 2017;9:159-176 pubmed publisher
    ..were newly detected in Group I while CPNS1, DPEP1, GANAB, GDIB, GGT1, HSPB1, ICTL, VILI, MUTA, NDKB, PTGR1, UCHL3, VAPB and VINC were newly detected in Group E...
  52. Tsai C, Soong B, Lin K, Tu P, Lin J, Lee Y. FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS. Neurobiol Aging. 2011;32:553.e13-21 pubmed publisher
    ..The authors analyzed these genes, including SOD1, FUS, VAPB, ANG, TDP-43, FIG4, and CHMP2B, in a cohort of 15 index patients of Han Chinese descent with adult-onset FALS...
  53. Li G, Alexander E, Schwartz J. Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. J Biol Chem. 2003;278:19791-7 pubmed publisher
    ..Interaction between the syntaxin-1A and H+-ATPase is important in the targeted exocytosis of the proton pump to the apical membrane of intercalated cells...
  54. Palicharla V, Maddika S. HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion. Cell Signal. 2015;27:2355-62 pubmed publisher
    ..In summary, we identified a novel functional role for non-canonical ubiquitin linkages in mediating protein secretion. ..
  55. Dong R, Saheki Y, Swarup S, Lucast L, Harper J, De Camilli P. Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. Cell. 2016;166:408-423 pubmed publisher
    VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membranes through which lipids are exchanged across adjacent bilayers...
  56. Darbyson A, Ngsee J. Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype. Exp Cell Res. 2016;341:18-31 pubmed publisher
    A mutation in VAPB causes a familial form of Amyotrophic Lateral Sclerosis...
  57. Aliaga L, Lai C, Yu J, Chub N, Shim H, Sun L, et al. Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons. Hum Mol Genet. 2013;22:4293-305 pubmed publisher
    ..B (VAPB) has been linked to an atypical autosomal dominant form of familial amyotrophic lateral sclerosis 8 (ALS8)...
  58. Ishikawa Sasaki K, Nagashima S, Taniguchi K, Sasaki J. Model of OSBP-Mediated Cholesterol Supply to Aichi Virus RNA Replication Sites Involving Protein-Protein Interactions among Viral Proteins, ACBD3, OSBP, VAP-A/B, and SAC1. J Virol. 2018;92: pubmed publisher silencing cellular proteins known to be components of this pathway, OSBP, the ER membrane proteins VAPA and VAPB (VAP-A/B), the PI4P-phosphatase SAC1, and PI-transfer protein β...
  59. Polgar J, Chung S, Reed G. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Blood. 2002;100:1081-3 pubmed
    ..In contrast, rVAMP-2, which formed SNARE complexes in vitro, had no effect on platelet exocytosis. We conclude that VAMP-3 and VAMP-8 form SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion. ..
  60. Di L, Chen H, Da Y, Wang S, Shen X. Atypical familial amyotrophic lateral sclerosis with initial symptoms of pain or tremor in a Chinese family harboring VAPB-P56S mutation. J Neurol. 2016;263:263-8 pubmed publisher
    ..Mutations associated with ALS have been identified in more than 20 genes, but ALS type 8 (ALS8), which is caused by mutations in vesicle-associated membrane protein-associated protein B (VAPB), is rare...
  61. Gupta G, Song J. C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex. PLoS ONE. 2016;11:e0147278 pubmed publisher
    ..Previous functional studies have already established that the human ER-anchored VAPB protein acts as a host factor to form a complex with HCV NS5A and NS5B, which may be established as a drug target...
  62. Goyal S, Gupta G, Qin H, Upadya M, Tan Y, Chow V, et al. VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B. PLoS ONE. 2012;7:e40341 pubmed publisher
    ..machinery needs to be formed by both HCV non-structural proteins (including NS5B) and human host factors such as VAPB. Recently, the 99-residue VAPC, a splicing variant of VAPB, was demonstrated to inhibit HCV replication via binding ..
  63. Chao J, Wong A, Tavassoli S, Young B, Chruscicki A, Fang N, et al. Polarization of the endoplasmic reticulum by ER-septin tethering. Cell. 2014;158:620-32 pubmed publisher
    ..ER-septin tethering polarizes the ER into separate mother and bud domains, one function of which is to position the spindle in the mother until M phase by confining the spindle capture protein Num1 to the mother ER. ..
  64. Alpy F, Rousseau A, Schwab Y, Legueux F, Stoll I, Wendling C, et al. STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. J Cell Sci. 2013;126:5500-12 pubmed publisher
    ..An in situ proximity ligation assay between STARD3, STARD3NL and VAP proteins identified endogenous LE-ER MCS. Thus, we report here the identification of proteins involved in inter-organellar interaction. ..
  65. Larroquette F, Seto L, Gaub P, Kamal B, Wallis D, Larivière R, et al. Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Hum Mol Genet. 2015;24:6515-29 pubmed publisher
    Missense mutations (P56S) in Vapb are associated with autosomal dominant motor neuron diseases: amyotrophic lateral sclerosis and lower motor neuron disease...
  66. van Blitterswijk M, van Es M, Koppers M, van Rheenen W, Medic J, Schelhaas H, et al. VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient. Neurobiol Aging. 2012;33:2950.e1-4 pubmed publisher
    ..97 families), and 765 control subjects of Dutch descent for mutations in vesicle-associated membrane protein B (VAPB). We have identified 1 novel VAPB mutation (p...
  67. Guo Y, Yao J, Sun C, Wen Z, Wang X. Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli. Toxins (Basel). 2016;8: pubmed publisher
    ..Here, we characterized a type II VapC/VapB TA system from the deep-sea derived Streptomyces sp. SCSIO 02999...
  68. Wakana Y, Kotake R, Oyama N, Murate M, Kobayashi T, Arasaki K, et al. CARTS biogenesis requires VAP-lipid transfer protein complexes functioning at the endoplasmic reticulum-Golgi interface. Mol Biol Cell. 2015;26:4686-99 pubmed publisher
    ..On the basis of these findings, we propose that the ER-Golgi contacts play a pivotal role in lipid metabolism to control the biogenesis of transport carriers from the TGN. ..
  69. Scifo E, Szwajda A, Soliymani R, Pezzini F, Bianchi M, Dapkunas A, et al. Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015;123:42-53 pubmed publisher
    ..Moreover, the PPT1 IP implicate the enzyme in novel roles including: involvement in neuronal migration and dopamine receptor mediated signalling pathway. ..
  70. Sanhueza M, Chai A, Smith C, McCray B, Simpson T, Taylor J, et al. Network analyses reveal novel aspects of ALS pathogenesis. PLoS Genet. 2015;11:e1005107 pubmed publisher the human VAMP-associated protein B (hVAPB) cause a heterogeneous group of motor neuron diseases including ALS8. Despite extensive research, the molecular mechanisms underlying ALS pathogenesis remain largely unknown...
  71. Paillusson S, Gomez Suaga P, Stoica R, LITTLE D, Gissen P, Devine M, et al. α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production. Acta Neuropathol. 2017;134:129-149 pubmed publisher
    ..that are mediated by binding of the integral ER protein vesicle-associated membrane protein-associated protein B (VAPB) to the outer mitochondrial membrane protein, protein tyrosine phosphatase-interacting protein 51 (PTPIP51)...
  72. Burja S, Belec T, Bizjak N, Mori J, Markota A, Sinkovic A. Efficacy of a bundle approach in preventing the incidence of ventilator associated pneumonia (VAP). Bosn J Basic Med Sci. 2018;18:105-109 pubmed publisher
    ..5% versus 30.9%, p = 0.027). Overall, our results support the use of VAP prevention bundle in clinical practice. ..
  73. Deep A, Kaundal S, Agarwal S, Singh R, Thakur K. Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly. FEBS J. 2017;284:4066-4082 pubmed publisher
    ..Under stress conditions, the VapB antitoxin is degraded by cellular proteases to release a free VapC toxin, which in turn inhibits cell growth mainly ..
  74. Gupta G, Qin H, Song J. Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations. PLoS ONE. 2012;7:e39261 pubmed publisher
    ..So far no biophysical characterization of this interaction has been reported. Here, we dissected the 243-residue VAPB into 4 and 447-residue NS5A into 10 fragments, followed by CD and NMR characterization of their structural ..
  75. Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, et al. Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. J Immunol. 2000;164:5850-7 pubmed
    ..Furthermore, these results are the first demonstration that the nonneuronal VAMP8 isoform, originally localized on early endosomes, is present in a regulated secretory compartment. ..
  76. Schultz J, Lee S, Cole T, Hoang H, Vibbert J, Cottee P, et al. The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1. Development. 2017;144:2175-2186 pubmed publisher
    ..Secreted MSPds derived from the C. elegans VAPB homolog VPR-1 promote mitochondrial localization to actin-rich I-bands in body wall muscle...