Gene Symbol: UXS1
Description: UDP-glucuronate decarboxylase 1
Alias: SDR6E1, UGD, UDP-glucuronic acid decarboxylase 1, UXS-1, short chain dehydrogenase/reductase family 6E, member 12
Species: human
Products:     UXS1

Top Publications

  1. Fischer B, Ly T, Hendig D, Kuhn J, Pécheur E, Reungoat E, et al. First description of a compensatory xylosyltransferase I induction observed after an antifibrotic UDP-treatment of normal human dermal fibroblasts. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..pseudo-fibrotic XT increasement could be attributed to a compensation of decreased UDP-glucuronate decarboxylase 1 (UXS1) mRNA expression as well as a diminished intracellular UDP-xylose concentration...
  2. Schäper S, Wendt H, Bamberger J, Sieber V, Schmid J, Becker A. A Bifunctional UDP-Sugar 4-Epimerase Supports Biosynthesis of Multiple Cell Surface Polysaccharides in Sinorhizobium meliloti. J Bacteriol. 2019;201: pubmed publisher
    ..Here, we report that the S. meliloti Rm2011 uxs1-uxe-apsS-apsH1-apsE-apsH2 (SMb20458-63) gene cluster directs biosynthesis of an arabinose-containing ..
  3. Walker Whitworth K, Kaye Marshall A, Symanski E. Drilling and Production Activity Related to Unconventional Gas Development and Severity of Preterm Birth. Environ Health Perspect. 2018;126:037006 pubmed publisher
    Studies of unconventional gas development (UGD) and preterm birth (PTB) have not presented risk estimates by well development phase or trimester. We examined phase and trimester-specific associations between UGD activity and PTB...
  4. Ish J, Symanski E, Whitworth K. Exploring Disparities in Maternal Residential Proximity to Unconventional Gas Development in the Barnett Shale in North Texas. Int J Environ Res Public Health. 2019;16: pubmed publisher
    ..This study explores sociodemographic disparities in residential proximity to unconventional gas development (UGD) among pregnant women...
  5. Eames B, Singer A, Smith G, Wood Z, Yan Y, He X, et al. UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Dev Biol. 2010;341:400-15 pubmed publisher
    UDP-xylose synthase (Uxs1) is strongly conserved from bacteria to humans, but because no mutation has been studied in any animal, we do not understand its roles in development. Furthermore, no crystal structure has been published...
  6. Rodionova I, Goodacre N, Do J, Hosseinnia A, Babu M, Uetz P, et al. The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-γ-glutamate synthase FolC. J Biol Chem. 2018;293:15725-15732 pubmed publisher
    ..uridylyltransferase (GlnD), THF-dependent tRNA modification enzyme (MnmE), and UDP-glucose dehydrogenase (Ugd) as shown by direct in vitro protein-protein interactions...
  7. Alkhateeb R, Vorhölter F, Steffens T, Ruckert C, Ortseifen V, Hublik G, et al. Comparative transcription profiling of two fermentation cultures of Xanthomonas campestris pv. campestris B100 sampled in the growth and in the stationary phase. Appl Microbiol Biotechnol. 2018;102:6613-6625 pubmed publisher
    ..encoding enzymes involved in nucleotide sugar precursor synthesis of xanthan biosynthesis, such as xanA, galU, and ugd, exhibited a transcription pattern that did not change during the growth and stationary phase...
  8. Asseeva P, Paladino N, Guerin C, Castinetti F, Vaillant Lombard J, Abdullah A, et al. Value of 123I/99mTc-sestamibi parathyroid scintigraphy with subtraction SPECT/CT in primary hyperparathyroidism for directing minimally invasive parathyroidectomy. Am J Surg. 2019;217:108-113 pubmed publisher
    ..Outcomes from imaging modalities were reported as: uniglandular disease/(UGD), multiglandular disease/(MGD), or negative, and were compared to post-operative diagnoses...
  9. Hays J, Finkel M, Depledge M, Law A, Shonkoff S. Considerations for the development of shale gas in the United Kingdom. Sci Total Environ. 2015;512-513:36-42 pubmed publisher
    ..community about the potential impacts of shale gas and other types of unconventional natural gas development (UGD) on human health and the environment...

More Information


  1. Fukuto H, Vadyvaloo V, McPhee J, Poinar H, Holmes E, Bliska J. A Single Amino Acid Change in the Response Regulator PhoP, Acquired during Yersinia pestis Evolution, Affects PhoP Target Gene Transcription and Polymyxin B Susceptibility. J Bacteriol. 2018;200: pubmed publisher
    ..defective growth under a low-Mg2+ condition and decreased transcription of a PhoP target gene, ugd, as well as an ∼8-fold increase in the susceptibility to the antimicrobial peptide polymyxin B...
  2. Yan B, Stute M, Panettieri R, Ross J, Mailloux B, Neidell M, et al. Association of groundwater constituents with topography and distance to unconventional gas wells in NE Pennsylvania. Sci Total Environ. 2017;577:195-201 pubmed publisher
    Recently we reported an association of certain diseases with unconventional gas development (UGD). The purpose of this study is to examine UGD's possible impacts on groundwater quality in northeastern Pennsylvania...
  3. Stacy S, Brink L, Larkin J, Sadovsky Y, Goldstein B, Pitt B, et al. Perinatal outcomes and unconventional natural gas operations in Southwest Pennsylvania. PLoS ONE. 2015;10:e0126425 pubmed publisher
    Unconventional gas drilling (UGD) has enabled extraordinarily rapid growth in the extraction of natural gas. Despite frequently expressed public concern, human health studies have not kept pace...
  4. Duan X, Lu A, Gu B, Cai Z, Ma H, Wei S, et al. Functional characterization of the UDP-xylose biosynthesis pathway in Rhodothermus marinus. Appl Microbiol Biotechnol. 2015;99:9463-72 pubmed publisher
    UDP-glucuronic acid dehydrogenase (UGD) and UDP-xylose synthase (UXS) are the two enzymes responsible for the biosynthesis of UDP-xylose from UDP-glucose...
  5. Finkel M, Hays J, Law A. Unconventional natural gas development and human health: thoughts from the United States. Med J Aust. 2015;203:294-6 pubmed
    If unconventional gas development (UGD) continues to expand in Australia, the potential health and environmental impacts should be adequately addressed and preventive public health measures should be implemented...
  6. Goldstein B. The pertinence of Sutton's law to exposure science: Lessons from unconventional shale gas drilling. J Expo Sci Environ Epidemiol. 2018;28:427-436 pubmed publisher
    ..and explore these criteria in relation to potential human exposure resulting from unconventional gas drilling (UGD): (1) The technological processes possibly leading to release of the chemical or physical agents of concern are ..
  7. Zhong R, Teng Q, Haghighat M, Yuan Y, Furey S, Dasher R, et al. Cytosol-Localized UDP-Xylose Synthases Provide the Major Source of UDP-Xylose for the Biosynthesis of Xylan and Xyloglucan. Plant Cell Physiol. 2017;58:156-174 pubmed publisher
    ..There exist six UXS genes in the Arabidopsis thaliana genome; three of them (UXS1, UXS2 and UXS4) encode Golgi-localized enzymes and the other three (UXS3, UXS5 and UXS6) encode cytosol-localized ..
  8. Peng Y, Qi Y, Huang F, Chen X, Zhou Y, Ye L, et al. Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease. Oncotarget. 2016;7:78680-78687 pubmed publisher
    ..39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation...
  9. Kuang B, Zhao X, Zhou C, Zeng W, Ren J, Ebert B, et al. Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis. Mol Plant. 2016;9:1119-1131 pubmed publisher
    ..Although all six single AtUXS T-DNA mutants and the uxs1 usx2 uxs4 triple mutant show no obvious phenotype, the uxs3 uxs5 uxs6 triple mutant has an irregular xylem ..
  10. Gu B, Laborda P, Wei S, Duan X, Song H, Liu L, et al. Discovery and Biochemical Characterization of the UDP-Xylose Biosynthesis Pathway in Sphaerobacter thermophilus. Protein Pept Lett. 2016;23:1103-1110 pubmed
    ..oxidation/ decarboxylation of UDP-glucose, which is catalyzed by the enzymes UDPglucuronic acid dehydrogenase (UGD) and UDP-xylose synthase (UXS). UDPxylose biosynthesis is ubiquitous in animals and plants...
  11. Han J, Pan Y, Wang X, Zhang Y, Ma Z. Antisense expression of Gossypium barbadense UGD6 in Arabidopsis thaliana significantly alters cell wall composition. Sci China Life Sci. 2016;59:213-8 pubmed publisher
    Uridine diphosphate-glucose dehydrogenase (UGD, EC1.1.1.22 oxidizes UDP-Glc (UDP-D-glucose) to UDP-GlcA (UDP-D-glucuronate), a critical precursor of cell wall polysaccharides...
  12. Zhu Z, Liu X, Dong F, Guo M, Wang X, Wang Z, et al. Influence of fermentation conditions on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris. Appl Microbiol Biotechnol. 2016;100:3909-21 pubmed publisher
    ..of the phosphoglucomutase (PGM), UDPG-pyrophosphorylase (UGP), phosphoglucose isomerase (PGI), UDPG-dehydrogenase (UGD), and glucokinase (GK) implicated in metabolite synthesis in Cordyceps militaris was evaluated...
  13. Walsh R, Polizzi S, Kadirvelraj R, Howard W, Wood Z. Man o' war mutation in UDP-α-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation. Biochemistry. 2015;54:807-19 pubmed publisher
    ..The persistence of a latent hexamer-building interface in the human enzyme suggests that the ancestral UXS may have been a hexamer. ..
  14. Polizzi S, Walsh R, Peeples W, Lim J, Wells L, Wood Z. Human UDP-α-D-xylose synthase and Escherichia coli ArnA conserve a conformational shunt that controls whether xylose or 4-keto-xylose is produced. Biochemistry. 2012;51:8844-55 pubmed publisher
    ..Finally, we present evidence that the release of NADH and UX4O involves a cooperative conformational change that is conserved in both enzymes. ..
  15. Bakker H, Oka T, Ashikov A, Yadav A, Berger M, Rana N, et al. Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem. 2009;284:2576-83 pubmed publisher
    ..The data presented in this study suggest the bidirectional transport of UDP-xylose across endoplasmic reticulum/Golgi membranes and its role in controlling homeostasis of UDP-glucuronic acid and UDP-xylose production. ..
  16. Moriarity J, Hurt K, Resnick A, Storm P, Laroy W, Schnaar R, et al. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. J Biol Chem. 2002;277:16968-75 pubmed
    UDP-glucuronate decarboxylase (UGD) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans...
  17. Whitworth K, Marshall A, Symanski E. Maternal residential proximity to unconventional gas development and perinatal outcomes among a diverse urban population in Texas. PLoS ONE. 2017;12:e0180966 pubmed publisher
    To assess associations between unconventional natural gas development (UGD) and perinatal outcomes...
  18. Uebe S, Ehrlicher M, Ekici A, Behrens F, Böhm B, Homuth G, et al. Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients. BMC Med Genet. 2017;18:92 pubmed publisher
    ..of CNVs of the GWAS with an alternative quantitative method, two significantly associated CNVs remained, one near UXS1, the other one at the TRB locus...
  19. An D, Yang S, Kim B, Ahn J. Biosynthesis of two quercetin O-diglycosides in Escherichia coli. J Ind Microbiol Biotechnol. 2016;43:841-9 pubmed publisher
    ..UDP-xyloside was supplied by concomitantly expressing UDP-glucose dehydrogenase (ugd) and UDP-xyloside synthase (UXS) in the E. coli. Using these strategies, 65...
  20. Polizzi S, Walsh R, Le Magueres P, Criswell A, Wood Z. Human UDP-?-d-xylose synthase forms a catalytically important tetramer that has not been observed in crystal structures. Biochemistry. 2013;52:3888-98 pubmed publisher
    ..The higher activity of the tetramer coupled with the relative instability of the complex suggests that an association-dissociation mechanism may regulate hUXS activity. ..
  21. Hwang H, Horvitz H. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. Proc Natl Acad Sci U S A. 2002;99:14218-23 pubmed
    ..Progeny of sqv-7 and sqv-1 null mutants fail to initiate cytokinesis, possibly because they are unable to separate the plasma membrane from the eggshell, a defect analogous to that of incomplete vulval invagination. ..
  22. Wiweger M, Avramut C, de Andrea C, Prins F, Koster A, Ravelli R, et al. Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders. J Pathol. 2011;223:531-42 pubmed publisher
    ..for most GAGs; pinscher (pic/slc35b2), presenting defective sulphation of GAGs and other molecules; hi954 (uxs1), lacking Notch and most GAGs due to impaired protein xylosylation; and knypek (kny/gpc4), missing the protein core ..