utrophin

Summary

Gene Symbol: utrophin
Description: utrophin
Alias: DMDL, DRP, DRP1, utrophin, DRP-1, dystrophin-related protein 1
Species: human
Products:     utrophin

Top Publications

  1. Khurana T, Watkins S, Kunkel L. The subcellular distribution of chromosome 6-encoded dystrophin-related protein in the brain. J Cell Biol. 1992;119:357-66 pubmed
    Chromosome 6-encoded dystrophin-related-protein (DRP) shows significant structural similarities to dystrophin at the carboxyl terminus, though the two proteins are encoded on different chromosomes...
  2. Buckle V, Guenet J, Simon Chazottes D, Love D, Davies K. Localisation of a dystrophin-related autosomal gene to 6q24 in man, and to mouse chromosome 10 in the region of the dystrophia muscularis (dy) locus. Hum Genet. 1990;85:324-6 pubmed
    We have localised a dystrophin-related autosomal gene called DMDL (Duchenne muscular dystrophy-like) to human chromosome 61q24 by in situ hybridisation...
  3. Love D, Hill D, Dickson G, Spurr N, Byth B, Marsden R, et al. An autosomal transcript in skeletal muscle with homology to dystrophin. Nature. 1989;339:55-8 pubmed
    ..The dystrophin-related sequence identifies a 13-kb transcript in human fetal muscle and maps to chromosome 6. Thus, dystrophin may be a member of a family of functionally related large structural proteins in muscle. ..
  4. Ahn A, Kunkel L. Syntrophin binds to an alternatively spliced exon of dystrophin. J Cell Biol. 1995;128:363-71 pubmed
    ..In this recombinant expression system, the dystrophin relatives, human dystrophin related protein (DRP or utrophin) and the 87K postsynaptic protein from Torpedo electric organ, also bind to translated beta 1-syntrophin...
  5. Ahn A, Freener C, Gussoni E, Yoshida M, Ozawa E, Kunkel L. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J Biol Chem. 1996;271:2724-30 pubmed
    ..assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding region of dystrophin, utrophin/dystrophin related protein, and the Torpedo 87K protein.
  6. Deconinck A, Rafael J, Skinner J, Brown S, Potter A, Metzinger L, et al. Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy. Cell. 1997;90:717-27 pubmed
    ..We describe mice deficient for both dystrophin and the dystrophin-related protein utrophin. These mice show many signs typical of DMD in humans: they show severe progressive muscular dystrophy that ..
  7. Nawrotzki R, Loh N, Ruegg M, Davies K, Blake D. Characterisation of alpha-dystrobrevin in muscle. J Cell Sci. 1998;111 ( Pt 17):2595-605 pubmed
    ..the cell surface into macroclusters that contain acetylcholine receptors and another dystrophin-related protein, utrophin. This redistribution is not associated with tyrosine phosphorylation of alpha-dystrobrevin-1 by agrin...
  8. Wilson J, Putt W, Jimenez C, Edwards Y. Up71 and up140, two novel transcripts of utrophin that are homologues of short forms of dystrophin. Hum Mol Genet. 1999;8:1271-8 pubmed
    b>Utrophin is a large protein which accumulates at the neuromuscular synapse and myotendinous junctions in adult skeletal muscle, and is widely expressed in several non-skeletal muscle tissues...
  9. Adams M, Kramarcy N, Krall S, Rossi S, Rotundo R, Sealock R, et al. Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J Cell Biol. 2000;150:1385-98 pubmed
    ..alpha-Syn(-/)- neuromuscular junctions have undetectable levels of postsynaptic utrophin and reduced levels of acetylcholine receptor and acetylcholinesterase...

More Information

Publications122 found, 100 shown here

  1. Sherman D, Fabrizi C, Gillespie C, Brophy P. Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Neuron. 2001;30:677-87 pubmed
    ..Hence, the DRP2-dystroglycan complex likely has a distinct function in the terminal stages of PNS myelinogenesis, possibly in the regulation of myelin thickness. ..
  2. Austin R, Fox J, Werstuck G, Stafford A, Bulman D, Dally G, et al. Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion. J Biol Chem. 2002;277:47106-13 pubmed
    b>Utrophin is a component of the platelet membrane cytoskeleton and participates in cytoskeletal reorganization (Earnest, J. P., Santos, G. F., Zuerbig, S., and Fox, J. E. B. (1995) J. Biol. Chem. 270, 27259-27265)...
  3. Haenggi T, Fritschy J. Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue. Cell Mol Life Sci. 2006;63:1614-31 pubmed
    ..protein assembly associated with either the X-linked cytoskeletal protein dystrophin or its autosomal homologue utrophin. In striated muscle cells, the DGC links the extracellular matrix to the actin cytoskeleton and mediates three ..
  4. Perkins K, Basu U, Budak M, Ketterer C, Baby S, Lozynska O, et al. Ets-2 repressor factor silences extrasynaptic utrophin by N-box mediated repression in skeletal muscle. Mol Biol Cell. 2007;18:2864-72 pubmed
    b>Utrophin is the autosomal homologue of dystrophin, the protein product of the Duchenne's muscular dystrophy (DMD) locus...
  5. Tinsley J, Blake D, Roche A, Fairbrother U, Riss J, Byth B, et al. Primary structure of dystrophin-related protein. Nature. 1992;360:591-3 pubmed
    Dystrophin-related protein (DRP or 'utrophin') is localized in normal adult muscle primarily at the neuromuscular junction. In the absence of dystrophin in Duchenne muscular dystrophy (DMD) patients, DRP is also present in the sarcolemma...
  6. Blake D, Hawkes R, Benson M, Beesley P. Different dystrophin-like complexes are expressed in neurons and glia. J Cell Biol. 1999;147:645-58 pubmed
    ..alpha-Dystrobrevin-1 is associated with Dp71, utrophin, and syntrophin...
  7. James M, Nuttall A, Ilsley J, Ottersbach K, Tinsley J, Sudol M, et al. Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin. J Cell Sci. 2000;113 ( Pt 10):1717-26 pubmed
    ..In order to investigate the role of tyrosine phosphorylation of the utrophin-dystroglycan complex we treated suspended or adherent cultures of HeLa cells with peroxyvanadate and ..
  8. Lopez J, Kolster J, Zhang R, Adams J. Increased constitutive nitric oxide production by whole body periodic acceleration ameliorates alterations in cardiomyocytes associated with utrophin/dystrophin deficiency. J Mol Cell Cardiol. 2017;108:149-157 pubmed publisher
    ..In contrast, mice deficient for both dystrophin and utrophin (mdx/utrn-/-, or dKO) can be used to model severe DMD cardiomyopathy where pathophysiological ..
  9. van der Pijl E, van Putten M, Niks E, Verschuuren J, Aartsma Rus A, Plomp J. Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models. Eur J Neurosci. 2016;43:1623-35 pubmed publisher
    ..b>Utrophin, a dystrophin homologue, is also concentrated at the NMJ, and upregulated in DMD...
  10. Heller K, Montgomery C, Shontz K, Clark K, Mendell J, Rodino Klapac L. Human α7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice. Hum Gene Ther. 2015;26:647-56 pubmed publisher
    ..74.MCK.ITGA7 systemically at 5-7 days of age to the mdx/utrn(-/-) mouse deficient for dystrophin and utrophin, a severe mouse model of DMD...
  11. Kennedy T, Moir L, Hemming S, Edwards B, Squire S, Davies K, et al. Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle. Skelet Muscle. 2017;7:22 pubmed publisher
    ..Increasing the levels of the dystrophin-related-protein utrophin is a highly promising therapy for DMD and has been shown to improve pathology in dystrophin-deficient mice...
  12. Guiraud S, Squire S, Edwards B, Chen H, Burns D, Shah N, et al. Second-generation compound for the modulation of utrophin in the therapy of DMD. Hum Mol Genet. 2015;24:4212-24 pubmed publisher
    ..By pharmacologically modulating the expression of the dystrophin-related protein utrophin, we have previously demonstrated in dystrophin-deficient mdx studies, daily SMT C1100 treatment significantly ..
  13. Pant M, Sopariwala D, Bal N, Lowe J, Delfín D, RAFAEL FORTNEY J, et al. Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy. PLoS ONE. 2015;10:e0123875 pubmed publisher
    The utrophin-dystrophin deficient (DKO) mouse model has been widely used to understand the progression of Duchenne muscular dystrophy (DMD). However, it is unclear as to what extent muscle pathology affects metabolism...
  14. Chen H, Chin Y, Lundy D, Liang C, Chi Y, Kuo P, et al. Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis. Sci Rep. 2017;7:7372 pubmed publisher
    ..The mdx/utrn -/- mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD...
  15. Myllymäki S, Kämäräinen U, Liu X, Cruz S, Miettinen S, Vuorela M, et al. Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization. Mol Cell Proteomics. 2019;18:277-293 pubmed publisher
    ..the screening approach was validated by confirming the HD localization of two candidate β4-interacting proteins, utrophin (UTRN) and ELKS/Rab6-interacting/CAST family member 1 (ERC1)...
  16. Sherman D, Wu L, Grove M, Gillespie C, Brophy P. Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. J Neurosci. 2012;32:9419-28 pubmed publisher
    ..Drp2 loss causes corresponding increases in Dystrophin family members, utrophin and dystrophin Dp116, although dystroglycan remains unchanged...
  17. Oaks Z, Winans T, Caza T, Fernandez D, Liu Y, Landas S, et al. Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice. Arthritis Rheumatol. 2016;68:2728-2739 pubmed publisher
    ..Levels of the mitophagy initiator dynamin-related protein 1 (Drp1) were depleted while the activity of mTORC1 was increased in MRL/lpr mice...
  18. Reddy P, Yin X, Manczak M, Kumar S, Pradeepkiran J, Vijayan M, et al. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease. Hum Mol Genet. 2018;27:2502-2516 pubmed publisher
    ..Increased levels of mRNA and protein levels of mitochondrial fission genes, Drp1 and Fis1 and decreased levels fusion (Mfn1, Mfn2 and Opa1) biogenesis (PGC1α, NRF1, NRF2 & TFAM), autophagy (..
  19. de Oliveira Souza A, Couto Lima C, Rosa Machado M, Espreafico E, Pinheiro Ramos R, Alberici L. Protective action of Omega-3 on paraquat intoxication in Drosophila melanogaster. J Toxicol Environ Health A. 2017;80:1050-1063 pubmed publisher
    ..of genes involved either in mitochondrial dynamics or biogenesis promoted by EPA/DHA: dynamin-related protein (DRP1), mitochondrial assembly regulatory factor (MARF), mitochondrial dynamin like GTPase (OPA1), and peroxisome ..
  20. Lu Y, Li S, Wu H, Bian Z, Xu J, Gu C, et al. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells. Int J Mol Med. 2015;36:1223-32 pubmed publisher
    ..transcription factor A (Tfam), and in the protein expression of PGC-1α, parkin and dynamin 1-like protein 1 (Drp1) in the VSMCs...
  21. Li S, Zhao H, Wang Y, Shao Y, Liu J, Xing M. Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens. Poult Sci. 2019;98:734-744 pubmed publisher
    ..PCR demonstrated that B cell lymphoma/leukemia 2 (Bcl2) were significantly decreased and dynamin-related protein 1 (Drp1), Optic atrophy 1 (Opa1), mitochondrial fission factor 1 (Mfn1), Mfn2, p53, caspase-8, Bcl-2 associated X protein (..
  22. Kang J, Hong J, Lee S. Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. J Pineal Res. 2016;60:383-93 pubmed publisher
    ..CCl4-mediated decreases in mitochondrial fission- and fusion-related proteins, such as dynamin-related protein 1 (DRP1) and mitofusin 2, were also attenuated by melatonin...
  23. Yu T, Deuster P, Chen Y. Role of dynamin-related protein 1-mediated mitochondrial fission in resistance of mouse C2C12 myoblasts to heat injury. J Physiol. 2016;594:7419-7433 pubmed publisher
    ..and moderate heat shock appear to have different effects on the mitochondrial morphology and fission protein Drp1 in skeletal muscle cells. Mitochondrial integrity plays a key role in cell survival under heat stress...
  24. Ampawong S, Isarangkul D, Aramwit P. Sericin improves heart and liver mitochondrial architecture in hypercholesterolaemic rats and maintains pancreatic and adrenal cell biosynthesis. Exp Cell Res. 2017;358:301-314 pubmed publisher
    ..erythroid 2-related factor, Nrf-2), dysmorphic mitochondria in relation to fission (dynamin-related protein-1; Drp-1) and fusion (guanosine triphosphatase mutated in dominant optic atrophy; OPA-1) markers and biosynthetic markers (..
  25. Lin L, Zhang M, Yan R, Shan H, Diao J, Wei J. Inhibition of Drp1 attenuates mitochondrial damage and myocardial injury in Coxsackievirus B3 induced myocarditis. Biochem Biophys Res Commun. 2017;484:550-556 pubmed publisher
    ..In this study, we aimed to explore the role of Dynamin-related protein 1 (Drp1)-linked mitochondrial fission in VMC...
  26. Marques Aleixo I, Santos Alves E, Balça M, Rizo Roca D, Moreira P, Oliveira P, et al. Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers. Neuroscience. 2015;301:480-95 pubmed publisher
    ..Mitochondrial dynamics (Mfn1/2, OPA1 and DRP1) and auto(mito)phagy (LC3II, Beclin1, Pink1, Parkin, p62)-related proteins were also measured by Western blotting...
  27. Gao H, Madsen P, Nielsen U, Aamand G, Su G, Byskov K, et al. Including different groups of genotyped females for genomic prediction in a Nordic Jersey population. J Dairy Sci. 2015;98:9051-9 pubmed publisher
    ..was predicted for 8 traits in the Nordic total merit index through a genomic BLUP model using deregressed proof (DRP) as the response variable in all scenarios...
  28. Huang S, Huang C, Huang W, Lin T, Liao P, Wang P, et al. Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction. Sci Rep. 2017;7:40382 pubmed publisher
    ..decrease in the mitochondrial fusion proteins, Mfn1/2 and Opa1, as well as an increase in the fission protein Drp1. We concluded that mitochondrial dysfunction associated with dynamic change was involved in apoptosis and anti-..
  29. Ma C, Beyer A, Durand M, Clough A, Zhu D, NORWOOD TORO L, et al. Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins. Arterioscler Thromb Vasc Biol. 2018;38:622-635 pubmed publisher
    ..b>Drp-1 (dynamin-related protein 1) was overexpressed or silenced to test the role of this protein in cell survival or ..
  30. Singh S, Bandi S, Winder S, Mallela K. The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain. Biochemistry. 2014;53:1801-9 pubmed publisher
    ..We determined the actin binding affinity of isolated CH domains from human utrophin and compared them with the affinity of the full-length tandem CH domain...
  31. Rozacky J, Nemec A, Sweasy J, Kidane D. Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks. Oncotarget. 2015;6:24474-87 pubmed
    ..Pol β possesses DNA polymerase and dRP lyase activities, both of which are known to be important for efficient BER...
  32. Luo F, Herrup K, Qi X, Yang Y. Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis. Exp Neurol. 2017;292:21-34 pubmed publisher
    ..Here we show that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, is activated in primary OL cells exposed to TNF-α induced inflammation or ..
  33. Gao J, Wang L, Liu J, Xie F, Su B, Wang X. Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases. Antioxidants (Basel). 2017;6: pubmed publisher
    ..has been increasingly unraveled after the identi?cation of several key fusion and fission regulators such as Drp1, OPA1, and mitofusins...
  34. Rogers M, Maldonado N, Hutcheson J, Goettsch C, Goto S, Yamada I, et al. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017;121:220-233 pubmed publisher
    Mitochondrial changes occur during cell differentiation and cardiovascular disease. DRP1 (dynamin-related protein 1) is a key regulator of mitochondrial fission...
  35. Homouz D, Joyce Tan K, Shahir Shamsir M, Moustafa I, Idriss H. Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA Polymerase ?'s activity. J Mol Graph Model. 2017;79:192-193 pubmed publisher
    ..responsible for the polymerase activity and an 8kDa domain, which bind ssDNA and has a deoxyribose phosphate (dRP) lyase activity...
  36. Feng J, Chen X, Guan B, Li C, Qiu J, Shen J. Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury. Mol Neurobiol. 2018;55:6369-6386 pubmed publisher
    ..ONOO- could induce PINK1/Parkin-mediated mitophagy activation via triggering dynamin-related protein 1 (Drp1) recruitment to damaged mitochondria, contributing to cerebral I/R injury...
  37. Goh I, Lai O, Chew L. Prevalence and Risk of Polypharmacy Among Elderly Cancer Patients Receiving Chemotherapy in Ambulatory Oncology Setting. Curr Oncol Rep. 2018;20:38 pubmed publisher
    ..b>DRP was detected in 77...
  38. Sin J, Andres A, Taylor D, Weston T, Hiraumi Y, Stotland A, et al. Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy. 2016;12:369-80 pubmed publisher
    ..During early myogenic differentiation, autophagy is robustly upregulated and this coincides with DNM1L/DRP1 (dynamin 1-like)-mediated fragmentation and subsequent removal of mitochondria via SQSTM1 (sequestosome 1)-mediated ..
  39. Liddy J, Zelaznik H, Huber J, Rietdyk S, Claxton L, Samuel A, et al. The efficacy of the Microsoft KinectTM to assess human bimanual coordination. Behav Res Methods. 2017;49:1030-1047 pubmed publisher
    ..00-3.33 Hz). Continuous relative phase (CRP) and discrete relative phase (DRP) were used to quantify the means (mCRP and mDRP) and variability (sdCRP and sdDRP) of coordination patterns...
  40. Gou H, Zhao M, Xu H, Yuan J, He W, Zhu M, et al. CSFV induced mitochondrial fission and mitophagy to inhibit apoptosis. Oncotarget. 2017;8:39382-39400 pubmed publisher
    ..Mitochondrial fission caused by CSFV infection was further determined by mitochondrial fragmentation and Drp1 translocation into mitochondria using a confocal microscope...
  41. Abuarab N, Munsey T, Jiang L, Li J, Sivaprasadarao A. High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission. Sci Signal. 2017;10: pubmed publisher
    ..subsequent increase in mitochondrial Zn2+ Zn2+ promoted the recruitment of the fission factor Drp-1 to mitochondria to trigger their fission...
  42. Elwan A, Singh R, Patterson M, Roygard J, Horne D, Clothier B, et al. Influence of sampling frequency and load calculation methods on quantification of annual river nutrient and suspended solids loads. Environ Monit Assess. 2018;190:78 pubmed publisher
    ..soluble inorganic nitrogen (SIN), total nitrogen (TN), dissolved reactive phosphorus (DRP), total phosphorus (TP) and total suspended solids (TSS), in the Manawatu River, New Zealand...
  43. Mooij R, Mwampagatwa I, van Dillen J, Stekelenburg J. Antenatal corticosteroid therapy for foetal maturation in women with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania. BMC Pregnancy Childbirth. 2016;16:235 pubmed publisher
    ..UDOM/DRP/346). Thirty-six women with forty live foetuses were analysed...
  44. Wang H, Yeh M, Ho C, Hu M, Huang Y. Cross-sectional investigation of drug-related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud. Pharmacoepidemiol Drug Saf. 2017;26:71-80 pubmed publisher
    ..1 June-31 August 2015), the VMRCS were pre-download and arranged to the institute's required format, facilitated DRP detection. Clinical pharmacists then reviewed and evaluated the prescription data through pre-downloaded VMRCS...
  45. Ballmann C, Denney T, Beyers R, Quindry T, Romero M, Amin R, et al. Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice. Am J Physiol Heart Circ Physiol. 2017;312:H128-H140 pubmed publisher
    ..Histological analyses of heart tissues revealed higher expression and colocalization of utrophin and ?-sarcoglycan...
  46. Kandimalla R, Manczak M, Fry D, Suneetha Y, Sesaki H, Reddy P. Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease. Hum Mol Genet. 2016;25:4881-4897 pubmed publisher
    ..purpose of our study was to understand the protective effects of a partial reduction of dynamin-related protein 1 (Drp1) in Alzheimer’s disease (AD) progression and pathogenesis...
  47. Kuo C, Tsai M, Lin T, Tiao M, Wang P, Chuang J, et al. mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..dynamic proteins found elevated levels of HIF-1α causing an increased expression of dynamin-related protein 1 (DRP1) during hypoxia; further, the existence of mtDNA also resulted in higher expression of DRP1 during hypoxia...
  48. Nomura R, Sato T, Sato Y, Medin J, Kushimoto S, Yanagisawa T. Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. Redox Biol. 2017;13:407-417 pubmed publisher
    ..The mRNA expression of dynamin-related protein (Drp)1 and the Drp1 receptor mitochondrial fission factor (Mff) was upregulated whereas that of optic atrophy 1 (Opa1) was ..
  49. Ugarte Uribe B, Prévost C, Das K, Bassereau P, García Sáez A. Drp1 polymerization stabilizes curved tubular membranes similar to those of constricted mitochondria. J Cell Sci. 2017;: pubmed publisher
    b>Drp1, an 80-kDa mechanochemical GTPase of the dynamin superfamily, is required for mitochondrial division in mammals. Despite the role of Drp1 dysfunction in human disease, its molecular mechanism remains poorly understood...
  50. Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, et al. Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration. Diabetologia. 2015;58:2371-80 pubmed publisher
    ..We generated mice lacking the mitochondrial fission protein dynamin-related protein 1 (DRP1) in the liver (Drp1LiKO mice)...
  51. Koch J, Feichtinger R, Freisinger P, Pies M, Schrödl F, Iuso A, et al. Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy. J Med Genet. 2016;53:270-8 pubmed publisher
    ..shared between mitochondria and peroxisomes, and inherited defects in two such components (dynamin-related protein (DRP1) and ganglioside-induced differentiation-associated protein 1 (GDAP1)) have been associated with human disease...
  52. Sun A, Wang Y, Liu J, Yu X, Sun Y, Yang F, et al. Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state. Cell Biosci. 2016;6:36 pubmed publisher
    ..and cyclin D1 and higher mitochondrial fusion-fission protein expression levels for dynamin-related protein 1 (Drp 1) in human kidney arteries and in db/db mouse aorta...
  53. Dong Y, Undyala V, Przyklenk K. Inhibition of mitochondrial fission as a molecular target for cardioprotection: critical importance of the timing of treatment. Basic Res Cardiol. 2016;111:59 pubmed publisher
    ..mitochondrial fragmentation and (2) strategies aimed at inhibiting the translocation of dynamin-related protein 1 (DRP1: the 'master regulator' of fission) from the cytosol to the mitochondria, when initiated as a pretreatment, are ..
  54. Ma J, Yuan Y, Yuan D. Underway analysis of nanomolar dissolved reactive phosphorus in oligotrophic seawater with automated on-line solid phase extraction and spectrophotometric system. Anal Chim Acta. 2017;950:80-87 pubmed publisher
    ..report an automated portable analyzer for week-long underway analysis of nanomolar dissolved reactive phosphorus (DRP) in seawater...
  55. Marques Aleixo I, Santos Alves E, Torrella J, Oliveira P, Magalhaes J, Ascensao A. Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling. Cardiovasc Toxicol. 2018;18:43-55 pubmed publisher
    ..Mitochondrial dynamics (Mfn1, Mfn2, OPA1 and DRP1) and auto(mito)phagy (LC3, Beclin1, Pink1, Parkin and p62)-related proteins were semi-quantified...
  56. Standley R, Distefano G, Pereira S, Tian M, Kelly O, Coen P, et al. Effects of ?-hydroxy-?-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. J Appl Physiol (1985). 2017;123:1092-1100 pubmed publisher
    ..markers of mitochondrial content [oxidative phosphorylation (OXPHOS)], fusion and fission (MFN2, OPA1, FIS1, and DRP1), autophagy (Beclin1, LC3B, and BNIP3), and atrophy [poly-ubiquinated proteins (poly-ub)] by Western blot...
  57. Miropolskaya N, Petushkov I, Kulbachinskiy A, Makarova A. Identification of amino acid residues involved in the dRP-lyase activity of human Pol ι. Sci Rep. 2017;7:10194 pubmed publisher
    ..first of all, Pol β) several other human DNA polymerases from Y- and A- families were shown to possess the dRP-lyase activity and could serve as backup polymerases in base excision repair (Pol ι, Rev1, Pol γ and Pol θ)...
  58. Keep N, Winder S, Moores C, Walke S, Norwood F, Kendrick Jones J. Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer. Structure. 1999;7:1539-46 pubmed
    b>Utrophin is a large multidomain protein that belongs to a superfamily of actin-binding proteins, which includes dystrophin, alpha-actinin, beta-spectrin, fimbrin, filamin and plectin...
  59. Parameyong A, Govitrapong P, Chetsawang B. Melatonin attenuates the mitochondrial translocation of mitochondrial fission proteins and Bax, cytosolic calcium overload and cell death in methamphetamine-induced toxicity in neuroblastoma SH-SY5Y cells. Mitochondrion. 2015;24:1-8 pubmed publisher
    ..that METH significantly decreases cell viability and increases the levels of mitochondrial fission (Fis1 and Drp1) proteins and pro-apoptotic protein, Bax in isolated mitochondria...
  60. Blackstone C. KIF1Bβ and Neuroblastoma: Failure to Divide and Cull. Dev Cell. 2016;36:127-8 pubmed publisher
    ..2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation...
  61. Long A, Klimova N, Kristian T. Mitochondrial NUDIX hydrolases: A metabolic link between NAD catabolism, GTP and mitochondrial dynamics. Neurochem Int. 2017;109:193-201 pubmed publisher
    ..Recently, activated AMPK was reported to phosphorylate mitochondria fission factor (MFF), which increases Drp1 localization to the mitochondria and promotes mitochondrial fission...
  62. Cho B, Cho H, Jo Y, Kim H, Song M, Moon C, et al. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat Commun. 2017;8:15754 pubmed publisher
    ..This process is controlled by cytosolic actin-based constriction machinery and dynamin-related protein 1 (Drp1) on mitochondrial outer membrane (OMM)...
  63. Yu Y, Wang L, Delguste F, Durand A, Guilbaud A, Rousselin C, et al. Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway. Free Radic Biol Med. 2017;112:397-410 pubmed publisher
    ..Mitochondrial fragmentation and mitochondrial fission protein Drp1 and Fis1 expressions were increased in RAGE-/- mice...
  64. Kim J, Park S, Kim B, Choe Y, Lee D. Insulin-stimulated lipid accumulation is inhibited by ROS-scavenging chemicals, but not by the Drp1 inhibitor Mdivi-1. PLoS ONE. 2017;12:e0185764 pubmed publisher
    ..or the expression of adipogenic and mitochondrial dynamics-related proteins, with the exception of phosphorylated Drp1 (Ser616), in differentiated 3T3-L1 adipocytes...
  65. Ren X, Chen L, Xie J, Zhang Z, Dong G, Liang J, et al. Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes. Oxid Med Cell Longev. 2017;2017:4175353 pubmed publisher
    ..the effects of resveratrol on mitochondrial morphology and mitochondrial depolarization and on expressions of Drp1, parkin, PINK1, and LC3 were investigated in H9c2 cells after D-galactose treatment that induced senescent-like ..
  66. Ye S, Zhou T, Cheng K, Chen M, Wang Y, Jiang Y, et al. Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics. Nanoscale Res Lett. 2015;10:953 pubmed publisher
    ..led to excessive mitochondrial fission, increased mitochondrial localization of dynamin-related protein 1 (Drp1), both of which were markedly suppressed by C60-COOH pretreatment...
  67. Ozguzer A, Bayol U, Pala E, Akdeniz C, Degirmenci M. Does single receptor positive breast carcinoma differ with regard to age, tumor grade, and HER2 amplification status?. J BUON. 2016;21:21-6 pubmed
    ..receptor positive (SRP) (ER-/PR+ and ER+/PR-) breast carcinoma in comparison with the double receptor positive (DRP) (ER+/PR+) and double receptor negative (DRN) (ER-/PR-) tumors...
  68. Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Yagi T, et al. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of ?-lactam plus macrolide combination therapy. Respirology. 2017;: pubmed publisher
    Drug-resistant pathogen (DRP) risk stratification is important for choosing a treatment strategy for community-onset pneumonia...
  69. Ong S, Hausenloy D. Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases. Handb Exp Pharmacol. 2017;240:251-279 pubmed publisher
    ..Mfn1 and 2), and optic atrophy 1 (Opa1) as well as the mitochondrial fission proteins - dynamin-related peptide 1 (Drp1) and fission protein 1 (Fis1)...
  70. Matsuishi Y, Kato H, Masuda K, Yamaza H, Hirofuji Y, Sato H, et al. Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1. Biochem Biophys Res Commun. 2018;495:1655-1660 pubmed publisher
    ..The amount of dentin formed under DRP1 inhibition was significantly larger than that of the control...
  71. Belkin A, Burridge K. Localization of utrophin and aciculin at sites of cell-matrix and cell-cell adhesion in cultured cells. Exp Cell Res. 1995;221:132-40 pubmed
    Aciculin is a phosphoglucomutase-related cytoskeletal protein associated with dystrophin and/or utrophin in various tissues and cell types...
  72. Wang Q, Cao D, Lin C, Wang Z, Cui W, Jin C. [The regulation of UTROPHIN expression by EN1]. Yi Chuan. 2011;33:347-52 pubmed
    To investigate possible factors up-regulating the expression of UTROPHIN, potential regulatory elements in the promoter of the human UTROPHIN was predicted by P-match software and verified by EMSA and ChIP...
  73. Lin Y, Chang H, Chang F, Shen C, Liu C, Mao W, et al. Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes. FEBS Lett. 2013;587:3202-9 pubmed publisher
    ..This disruption was due to ABCG2 knockout elevating intracellular protoporphyrin IX, which led to upregulation of DRP-1-mediated mitochondrial fission...
  74. Murnane J, Brennan R, Healy M, Fenton O. Assessment of intermittently loaded woodchip and sand filters to treat dairy soiled water. Water Res. 2016;103:408-415 pubmed publisher
    ..nitrogen (TN), 82% ammonium-nitrogen (NH4N), 50% total phosphorus (TP), and 54% dissolved reactive phosphorus (DRP) were measured in 1 m deep woodchip filters, which was greater than the reductions in 0.6 m deep woodchip filters...
  75. Zhan L, Cao H, Wang G, Lyu Y, Sun X, An J, et al. Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma. Oncotarget. 2016;7:65001-65011 pubmed publisher
    ..We found that, increased mitochondrial fission by forced expression of Drp1 promoted the proliferation of HCC cells both in vitro and in vivo mainly by facilitating G1/S phase transition of ..
  76. Wu J, Zhang B, Wuu Y, Davidson M, Hei T. Targeted cytoplasmic irradiation and autophagy. Mutat Res. 2017;806:88-97 pubmed publisher
    ..was oxyradical-dependent and required the activity of the mitochondrial fission protein dynamin related protein 1 (DRP1)...
  77. Perdiz D, Lorin S, Leroy Gori I, Poüs C. Stress-induced hyperacetylation of microtubule enhances mitochondrial fission and modulates the phosphorylation of Drp1 at 616Ser. Cell Signal. 2017;39:32-43 pubmed publisher
    ..study, we show that under stress conditions, most of the mitochondria form foci with microtubule domains that carry Drp1. We also demonstrate that stress-induced hyperacetylation of microtubules is required for the effective induction ..
  78. Bido S, Soria F, Fan R, Bezard E, Tieu K. Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease. Sci Rep. 2017;7:7495 pubmed publisher
    ..Division Inhibitor-1 (mdivi-1), a putative inhibitor of the mitochondrial fission Dynamin-Related Protein-1 (Drp1). We show here that mdivi-1 reduced neurodegeneration, α-syn aggregates and normalized motor function...
  79. Mestres C, Agustí A, Hernandez M, Puerta L, Llagostera B. Pharmacist Intervention Program at Different Rent Levels of Geriatric Healthcare. Pharmacy (Basel). 2017;5: pubmed publisher
    ..to know physicians' acceptance of our recommendations, as well as the most prevalent drug related problems (DRP); and the impact of the pharmacists' interventions...
  80. Kjeldsen L, Nielsen T, Olesen C. Investigating the Relative Significance of Drug-Related Problem Categories. Pharmacy (Basel). 2017;5: pubmed publisher
    ..be related to specific drug-related problems (DRPs) and hence may assist in prioritizing individual categories of DRP categorization systems...
  81. Lemos V, de Oliveira R, Naia L, Szego E, Ramos E, Pinho S, et al. The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes. Hum Mol Genet. 2017;26:4105-4117 pubmed publisher
    ..Mechanistically, SIRT2 was able to increase fusion-related protein Mfn2 and decrease mitochondrial-associated Drp1. SIRT2 also attenuated the downregulation of TFAM, a key mtDNA-associated protein, contributing to the increase in ..
  82. Panda P, Naik P, Meher B, Das D, Mukhopadhyay S, Praharaj P, et al. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochim Biophys Acta Mol Cell Res. 2018;1865:480-495 pubmed publisher
    ..Further, upon pre-treatment with Mdivi-1, DRP1 inhibitor, AGG exposure results in suppression of apoptosis in U87MG cells indicating AGG-induced mitophagy ..
  83. Pearce M, Blake D, Tinsley J, Byth B, Campbell L, Monaco A, et al. The utrophin and dystrophin genes share similarities in genomic structure. Hum Mol Genet. 1993;2:1765-72 pubmed
    b>Utrophin and dystrophin are highly homologous proteins which are reciprocally expressed in DMD (Duchenne muscular dystrophy) muscle...
  84. Guo W, Nichol M, Merlie J. Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters. FEBS Lett. 1996;398:259-64 pubmed
    We have cloned and sequenced mouse utrophin cDNA, and successfully expressed full length utrophin (400 kDa) in both muscle and non-muscle cells...
  85. Perkins K, Davies K. Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression. FEBS Lett. 2003;538:168-72 pubmed
    ..deficiency, which can be prevented in the mdx mouse model by over-expression of an autosomal homologue, utrophin. Utrophin has two characterised full-length promoters, A and B...
  86. Lomnytska M, Dubrovska A, Hellman U, Volodko N, Souchelnytskyi S. Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients. Int J Cancer. 2006;118:412-21 pubmed
    ..Truncated forms of cytosolic serine hydroxymethyl transferase (cSHMT), T-box transcription factor 3 (Tbx3) and utrophin were aberrantly expressed in samples from cancer patients as compared to samples from noncancerous cases...
  87. Cereghetti G, Stangherlin A, Martins de Brito O, Chang C, Blackstone C, Bernardi P, et al. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A. 2008;105:15803-8 pubmed publisher
    ..Here, we show a role for calcineurin-dependent translocation of the profission dynamin related protein 1 (Drp1) to mitochondria in dysfunction-induced fragmentation...
  88. O Mealey G, Berry W, Plafker S. Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission. Redox Biol. 2017;11:103-110 pubmed publisher
    ..Mechanistically, SFN mitigates the recruitment and/or retention of the soluble fission factor Drp1 to mitochondria and to peroxisomes but does not affect overall Drp1 abundance...
  89. Daskalova S, Bhattacharya C, Dedkova L, Hecht S. Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase ? with Unnatural Lysine Analogues. Biochemistry. 2017;56:500-513 pubmed publisher
    ..Pol ?) is a key enzyme in mammalian base excision repair (BER), contributing stepwise 5'-deoxyribose phosphate (dRP) lyase and "gap-filling" DNA polymerase activities...
  90. Basit F, van Oppen L, Schöckel L, Bossenbroek H, van Emst de Vries S, Hermeling J, et al. Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 2017;8:e2716 pubmed publisher
    ..Dynamin-related protein 1 (Drp1) knockdown induced mitochondrial filamentation and inhibited BAY-induced cell death...
  91. Vo M, Ko M, Lee U, Yoon E, Lee B, Cho W, et al. Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1. Biochem Biophys Res Commun. 2017;486:1014-1020 pubmed publisher
    ..mitochondrial morphology by modulating the expression of the mitochondrial fission gene dynamin-related protein 1 (Drp1)...
  92. Kwon D, Park E, Sesaki H, Kang S. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017;493:737-743 pubmed publisher
    ..Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated ..