USP9Y

Summary

Gene Symbol: USP9Y
Description: ubiquitin specific peptidase 9, Y-linked
Alias: DFFRY, SPGFY2, deubiquitinating enzyme FAF-Y, fat facets protein-related, Y-linked, ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila), ubiquitin thioesterase FAF-Y, ubiquitin thiolesterase FAF-Y, ubiquitin-specific processing protease FAF-Y, ubiquitin-specific protease 9, Y chromosome, ubiquitin-specific-processing protease FAF-Y
Species: human

Top Publications

  1. ncbi Analysis of Yq microdeletions in infertile males by PCR and DNA hybridization techniques
    P Grimaldi
    Cattedra di Anatomia, , , Italy
    Mol Hum Reprod 4:1116-21. 1998
  2. pmc Adrenocorticotropic hormone and cAMP inhibit noninactivating K+ current in adrenocortical cells by an A-kinase-independent mechanism requiring ATP hydrolysis
    J J Enyeart
    Department of Pharmacology, Ohio State University, College of Medicine, Columbus 43210 1239, USA
    J Gen Physiol 108:251-64. 1996
  3. ncbi Male infertility: polymerase chain reaction-based deletion mapping of genes on the human chromosome
    N Viswambharan
    School of Biotechnology, Dr G R Damodaran College of Science, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
    Singapore Med J 48:1140-2. 2007
  4. ncbi Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes
    Ying Zhang
    Molecular Endocrinology Section, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development NIH, 49 Convent Drive, Building 49, Room 6A 36, Bethesda, MD 20892 4510, USA
    J Steroid Biochem Mol Biol 85:401-14. 2003
  5. ncbi Genetics of human male infertility
    J Poongothai
    Computational Engineering and Networking Department, Amrita Viswha Vidyapeetham, Ettimadai, Coimbatore 638107, Tamil Nadu, India
    Singapore Med J 50:336-47. 2009
  6. ncbi [Genetics and male infertility]
    K Stouffs
    Departement voor Embryologie en Genetica, Vrije Universiteit Brussel, Brussel
    Verh K Acad Geneeskd Belg 71:115-39. 2009
  7. ncbi [Sex chromosomes and male infertility]
    Yi Chao Shi
    Center of Reproduction and Genetics, PLA Research Institute of Clinical Laboratory Medicine, Nanjing University School of Medicine Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 16:460-7. 2010
  8. ncbi Genetics of azoospermia: current knowledge, clinical implications, and future directions. Part II: Y chromosome microdeletions
    Hossein Sadeghi-Nejad
    Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey, USA
    Urol J 4:192-206. 2007
  9. ncbi Y chromosome microdeletions and alterations of spermatogenesis
    C Foresta
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, 35128 Padua, Italy
    Endocr Rev 22:226-39. 2001
  10. pmc Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey
    M Balkan
    Department of Medical Biology and Genetic, Medical Faculty, University of Dicle, 21280, Diyarbakir, Turkey
    J Assist Reprod Genet 25:559-65. 2008

Detail Information

Publications176 found, 100 shown here

  1. ncbi Analysis of Yq microdeletions in infertile males by PCR and DNA hybridization techniques
    P Grimaldi
    Cattedra di Anatomia, , , Italy
    Mol Hum Reprod 4:1116-21. 1998
    ....
  2. pmc Adrenocorticotropic hormone and cAMP inhibit noninactivating K+ current in adrenocortical cells by an A-kinase-independent mechanism requiring ATP hydrolysis
    J J Enyeart
    Department of Pharmacology, Ohio State University, College of Medicine, Columbus 43210 1239, USA
    J Gen Physiol 108:251-64. 1996
    ..The simultaneous activation of A-kinase- and Ca(2+)-dependent pathways produces the full steroidogenic response...
  3. ncbi Male infertility: polymerase chain reaction-based deletion mapping of genes on the human chromosome
    N Viswambharan
    School of Biotechnology, Dr G R Damodaran College of Science, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
    Singapore Med J 48:1140-2. 2007
    ..Several genes located in AZF regions for spermatogenesis is viewed as "AZF candidate genes". This study aims at PCR-based rapid analysis of Y chromosome microdeletion, which is a cause for male infertility...
  4. ncbi Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes
    Ying Zhang
    Molecular Endocrinology Section, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development NIH, 49 Convent Drive, Building 49, Room 6A 36, Bethesda, MD 20892 4510, USA
    J Steroid Biochem Mol Biol 85:401-14. 2003
    ....
  5. ncbi Genetics of human male infertility
    J Poongothai
    Computational Engineering and Networking Department, Amrita Viswha Vidyapeetham, Ettimadai, Coimbatore 638107, Tamil Nadu, India
    Singapore Med J 50:336-47. 2009
    ..The introduction of molecular techniques has provided great insight into the genetics of infertility. Yet, our understanding of the genetic causes of male infertility remains limited...
  6. ncbi [Genetics and male infertility]
    K Stouffs
    Departement voor Embryologie en Genetica, Vrije Universiteit Brussel, Brussel
    Verh K Acad Geneeskd Belg 71:115-39. 2009
    ..This low frequency of mutations has also been confirmed in several published studies. Therefore, further research is necessary to determine the impact of genetic causes on male infertility...
  7. ncbi [Sex chromosomes and male infertility]
    Yi Chao Shi
    Center of Reproduction and Genetics, PLA Research Institute of Clinical Laboratory Medicine, Nanjing University School of Medicine Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 16:460-7. 2010
    ..Many researches have been conducted on the relationship between spermatogenesis and the genes on the X chromosome, but the involvement of the X chromosome in male infertility remains less understood and deserves further characterization...
  8. ncbi Genetics of azoospermia: current knowledge, clinical implications, and future directions. Part II: Y chromosome microdeletions
    Hossein Sadeghi-Nejad
    Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey, USA
    Urol J 4:192-206. 2007
    ..We reviewed the most recent advances in the genetics of male infertility focusing on Y chromosome microdeletions...
  9. ncbi Y chromosome microdeletions and alterations of spermatogenesis
    C Foresta
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, 35128 Padua, Italy
    Endocr Rev 22:226-39. 2001
    ..Deletions in these regions remove one or more of the candidate genes (DAZ, RBMY, USP9Y, and DBY) and cause severe testiculopathy leading to male infertility...
  10. pmc Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey
    M Balkan
    Department of Medical Biology and Genetic, Medical Faculty, University of Dicle, 21280, Diyarbakir, Turkey
    J Assist Reprod Genet 25:559-65. 2008
    ....
  11. ncbi Screening for AZF deletion in a large series of severely impaired spermatogenesis patients
    M C Martinez
    Equipo IVI Murcia, Spain
    J Androl 21:651-5. 2000
    ..Because men with severe infertility suffer a high risk of Y chromosome deletion, screening for these men is recommended prior to treatment with assisted reproduction...
  12. ncbi Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3
    Manon Gaudreault
    Oncology and Molecular Endocrinology Research Center and the
    Invest Ophthalmol Vis Sci 48:3490-505. 2007
    ..Laminin is recognized by receptors (alpha6beta1 and alpha6beta4) that belong to the integrin family. The authors characterized the regulatory influence exerted by laminin on the Sp1/Sp3-mediated alpha6 gene promoter function...
  13. ncbi [Using multiplex PCR to analyze the breakpoint of a severe Y-chromosome deletion]
    Xiao su Xiao
    Laboratory of Genetics, Reproductive Medical Center, Shenzhen Hospital of Beijing University, Shenzhen, Guangdong, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:560-2. 2005
    ..To elucidate the relationship between azoospermia factor(AZF) microdeletion of Y chromosome and azoospermia, the exact breakpoint of a severe Y-chromosome deletion was determined according to the physical map of AZF...
  14. pmc Screening of 'Y' chromosome microdeletions in Iranian infertile males
    Ali Mohammad Malekasgar
    Department of Biochemistry, Genetic Unit, Ahwaz Jondishapur University of Medical Sciences, Iran
    J Hum Reprod Sci 1:2-9. 2008
    ....
  15. ncbi Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?
    Peter H Vogt
    Section Molecular Genetics and Infertility, Department Gynecol Endocrinol and Reproductive Medicine, University of Heidelberg, D 69115 Heidelberg, Germany
    APMIS 111:115-26; discussion 126-7. 2003
    ....
  16. ncbi Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities
    S K Mahadevaiah
    Laboratory of Developmental Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Hum Mol Genet 7:715-27. 1998
    ..In man, deletion of the functional copies of RBM is associated with meiotic arrest rather than sperm anomalies; however, the different effects of deletion are consistent with the differences in expression between the two species...
  17. ncbi T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells
    J J Enyeart
    Department of Pharmacology, Ohio State University College of Medicine Columbus 43210 1239
    Mol Endocrinol 7:1031-40. 1993
    ..They also suggest that these low voltage-activated channels, acting as the primary pathway for Ca2+ entry into AZF cells, couple ACTH-stimulated membrane depolarization to steroid hormone production...
  18. pmc Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB
    Ying Zhang
    Section on Molecular Endocrinology, Endocrinology, and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:6958-72. 2003
    ....
  19. pmc Unique signatures of natural background radiation on human Y chromosomes from Kerala, India
    Sanjay Premi
    Molecular Genetics Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
    PLoS ONE 4:e4541. 2009
    ..We studied the human Y chromosome in 390 males from the South Indian state of Kerala, where the level of natural background radiation (NBR) is ten-fold higher than the worldwide average, and that from 790 unexposed males as control...
  20. ncbi A frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese population
    B Wu
    The Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University School of Public Health, Nanjing, China
    Hum Reprod 22:1107-13. 2007
    ..In this study, we assessed the occurrence of classical AZF deletions and AZFc subdeletions and their impact on male infertility in a Han-Chinese population...
  21. ncbi Genetic aspects of male infertility
    M Namiki
    Department of Urology, Kanazawa University School of Medicine, Ishikawa, Japan
    World J Surg 24:1176-9. 2000
    ..Several unknown sequences were identified by the analysis. Ongoing studies on AZF will prove useful in the diagnosis and treatment of male infertility...
  22. pmc Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles
    Denis V Gribkov
    Department of Chemistry, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 129:11750-5. 2007
    ....
  23. ncbi An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1
    John J Enyeart
    Department of Neuroscience, The Ohio State University, College of Medicine, 5190 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210 1239, USA
    J Biol Chem 277:49186-99. 2002
    ..The activation of I(AC) by ATP indicates that native bTREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein...
  24. pmc Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication
    Mohamed I Khalil
    Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, The State University of New York, Buffalo, New York 14214, USA
    J Virol 82:11723-33. 2008
    ..They may also have implications regarding establishment or reactivation of viral latency...
  25. ncbi SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene
    Tomoaki Niimi
    Sekiguchi Biomatrix Signaling Project, ERATO, Japan Science and Technology Agency, Aichi Medical University, Karimata, Yazako, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 279:38055-61. 2004
    ....
  26. ncbi Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Division of Pediatric Hematology Oncology, Children s Hospital of Michigan, Detroit, MI 48201, USA
    Blood 101:1551-7. 2003
    ....
  27. ncbi Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP
    James A Maclean
    Department of Immunology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Reprod 73:1126-34. 2005
    ....
  28. ncbi The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region
    S Mazeyrat
    INSERM U491, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Hum Mol Genet 7:1713-24. 1998
    ..genes have previously been mapped within the interval: Ube1y and Smcy, linked with Zfy1 on a contig of 250 kb, and Dffry and Uty, which were unanchored. The interval was estimated to be >450 kb...
  29. ncbi Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 promoter: role of Sp1/3, E-box binding factors, and an oncostatin M-responsive element
    Thomas Langmann
    Institute for Clinical Chemistry, University of Regensburg, 93042 Regensburg, Germany, and the Pharma Research Center, Bayer AG, Aprather Wey 18a, D 42096 Wuppertal, Germany
    J Biol Chem 277:14443-50. 2002
    ....
  30. doi Structural and functional characterization of the mouse tescalcin promoter
    Erasmo M Perera
    Department of Pediatrics, Endocrinology Division, University of Miami, Leonard Miller School of Medicine, Miami, FL 33136, USA
    Gene 464:50-62. 2010
    ..Taken together, the data demonstrated that Sp1 and Sp3 transcription factors cooperate positively in the regulation of Tesc promoter, and that the putative ZF5 motif is critical for its activation...
  31. ncbi A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor
    Juying Dong
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:18825-36. 2006
    ..Estradiol produced in breast stroma and adipose tissue, which are major sources of estrogen in post-menopausal women, could up-regulate hPRLR gene expression and stimulate breast tumor growth...
  32. ncbi Reciprocal modulation of voltage-gated and background K(+) channels mediated by nucleotides and corticotropin
    J J Enyeart
    Department of Neuroscience, The Ohio State University, College of Medicine, Columbus, Ohio 43210 1239, USA
    Mol Pharmacol 60:114-23. 2001
    ..This may represent a unique mechanism for transducing biochemical signals to ionic events involved in cortisol secretion...
  33. ncbi Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells
    Ningwu Huang
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0978, USA
    Mol Endocrinol 19:2020-34. 2005
    ..Transcription of cytochrome b5 shares many features with the regulation of P450c17, whose activity it enhances...
  34. doi [Breakpoint localization of Y-chromosome massive deletions in 49 spermatogenesis dysfunction patients]
    Xiangdong Tu
    PLA Center for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Region, Fuzhou, Fujian, 350025 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:686-9. 2009
    ..To analyze the characteristics of azoospermia factor(AZF) deletions in Y-chromosome...
  35. ncbi Physiological concentrations of insulin promote binding of nuclear proteins to the insulin-like growth factor I gene
    E N Kaytor
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Endocrinology 142:1041-9. 2001
    ..As most insulin-responsive genes do not exhibit insulin-responsive nuclear factor binding, further studies of IRBP may also contribute to understanding of the mechanism of insulin action on gene transcription...
  36. ncbi The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells
    Jacob B Griffin
    Department of Nutritional Science and Dietetics, University of Nebraska at Lincoln, Lincoln, NE, USA
    J Nutr 133:3409-15. 2003
    ..This study provides evidence that some effects of biotin on gene expression might be mediated by the nuclear abundance of Sp1 and Sp3...
  37. doi [Y chromosome and male infertility: what is a normal Y chromosome?]
    Ken McElreavey
    Reproduction, Fertilite et Populations, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Soc Biol 202:135-41. 2008
    ..Trying to correlate these changes with the phenotypic variability is a major challenge and it is likely that there will not be a single reference (or normal) Y chromosome sequence but many...
  38. ncbi AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men
    Laila Imken
    Human Genetic and Cytogenetic Unit, Research Department, Pasteur Institute of Morocco, Ezzahraoui 20100 Casablanca, Morocco
    Asian J Androl 9:674-8. 2007
    ..To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions...
  39. ncbi Sex chromosome alignment at meiosis of azoospermic men with azoospermia factor microdeletion
    Leah Yogev
    Institute for the Study of Fertility, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Androl 25:110-6. 2004
    ....
  40. ncbi Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer
    H Ceelie
    Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 1:1688-98. 2003
    ..Overexpression of prothrombin leads to an increased risk of venous thrombosis. Therefore, the study of the transcriptional regulation of the prothrombin gene may help to identify mechanisms of overexpression...
  41. ncbi Physical properties of ultrafast deposited micro- and nanothickness amorphous hydrogenated carbon films for medical devices and prostheses
    T Zaharia
    Department of Electronic Engineering and Applied Physics, University of Aston, Aston Triangle, Birmingham B4 7ET, UK
    Proc Inst Mech Eng H 221:161-72. 2007
    ....
  42. ncbi Corticotropin induces the expression of TREK-1 mRNA and K+ current in adrenocortical cells
    Judith A Enyeart
    Department of Neuroscience, The Ohio State University, College of Medicine, Columbus, OH, USA
    Mol Pharmacol 64:132-42. 2003
    ....
  43. ncbi Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases
    Robert J Phillips
    School of Surgical and Reproductive Sciences Obstetrics and Gynecology, University of Newcastle upon Tyne, 3rd Floor, William Leech Building, Faculty of Medical Sciences, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Clin Endocrinol Metab 90:3479-90. 2005
    ....
  44. ncbi Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Biochim Biophys Acta 1579:73-80. 2002
    ..Characterization of CBS promoter structure and function should clarify the molecular bases for variations in CBS gene expression in genetic diseases and the relationship between CBS and Down's syndrome (DS)...
  45. ncbi Role of Sp1 and Sp3 in the nutrient-regulated expression of the human asparagine synthetase gene
    Van Leung-Pineda
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 277:16585-91. 2002
    ..Sp1 expression increased basal transcription but did not cause a further increase when SL2 cells were amino acid-deprived. Sp3 expression enhanced both the basal and the starvation-induced transcription...
  46. doi The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation
    Giridhar Mudduluru
    Department of Experimental Surgery Mannheim Molecular Oncology of Solid Tumors, Mannheim Medical Faculty, Ruprecht Karls University Heidelberg, German Cancer Research Center DKFZ Heidelberg, 68167 Mannheim, Germany
    Biosci Rep 28:161-76. 2008
    ..This might enhance the understanding and treatment of essential mechanisms associated with cancer and other diseases...
  47. ncbi Transcriptional regulation of mouse delta-opioid receptor gene by CpG methylation: involvement of Sp3 and a methyl-CpG-binding protein, MBD2, in transcriptional repression of mouse delta-opioid receptor gene in Neuro2A cells
    Guilin Wang
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:40550-6. 2003
    ....
  48. ncbi 7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3
    Aruna S Jaiswal
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Carcinogenesis 27:252-61. 2006
    ..From these results we conclude that the increased pAPCP promoter activity in the MCF10A cell line in response to DMBA treatment is mediated by Sp3...
  49. ncbi Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1
    Alia Al-Sarraj
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D 66421 Homburg, Germany
    J Cell Biochem 94:153-67. 2005
    ..This does not exclude the existence of composite Sp1/Sp3/Egr-1 binding sites, where competition for a common DNA-binding site occurs...
  50. ncbi Homologous recombination between HERVs causes duplications in the AZFa region of men accidentally exposed to cesium-137 in Goiânia
    J T Arruda
    Departamento de Biologia, Núcleo de Pesquisas Replicon, Universidade Catolica de Goias, Goiania, GO, Brasil
    Genet Mol Res 7:1063-9. 2008
    ..Consequently, the hotspots inside HERV mediated recombination in AZFa, and the duplication diversity was compatible with male fertility, since to date, none of the exposed individuals have demonstrated fertility disorders...
  51. pmc Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1
    B Majello
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita Federico II, Naples, Italy
    Nucleic Acids Res 22:4914-21. 1994
    ..We found that the cooperative interaction between NF-kappa B and Sp1 is highly specific, since neither Sp3 nor Sp4 is capable of cooperating with NF-kappa B...
  52. pmc CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383
    Louise N Reynard
    Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Hum Genet 133:1059-73. 2014
    ..This data suggest that the differential methylation of the +37 CpG site between osteoarthritic hip and knee cartilage may be responsible for the knee-specific effect of rs143383 on OA susceptibility...
  53. doi [Screening of azoospermia factor microdeletions on Y chromosome in infertile men by QF-PCR]
    Zhang Yuanyuan
    Department of Clinical Genetics, Shengjing Hospital, China Medical University, Shenyang 110004, China
    Yi Chuan 36:552-7. 2014
    ..It could serve as an effective technique for screening Y-microdeletions, and thus have general application in diagnosis and treatment of male infertility. ..
  54. pmc Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure
    Sjoerd Repping
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Am J Hum Genet 71:906-22. 2002
    ..The restriction of the associated phenotype to spermatogenic failure indicates the remarkable functional specialization of the affected regions of the Y chromosome...
  55. ncbi [Types of Y chromosome deletions and their frequency in infertile men]
    V B Chernykh
    Genetika 42:1130-6. 2006
    ..This indicates that the mechanisms underlying Yq macro- and microdeletions are somewhat different. The issues related to the role of Y chromosome deletions in the origins of monosomy for X chromosome and X/XY mosaicism are discussed...
  56. ncbi Evolution of Sp transcription factors
    Kevin J Kolell
    Division of Molecular Biology and Biochemistry, School of Biological Science, University of Missouri Kansas City
    Mol Biol Evol 19:216-22. 2002
    ..These results suggest that these different domains have different evolutionary histories...
  57. ncbi The PKR kinase promoter binds both Sp1 and Sp3, but only Sp3 functions as part of the interferon-inducible complex with ISGF-3 proteins
    Simone Visosky Ward
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara 93106, USA
    Virology 313:553-66. 2003
    ....
  58. ncbi Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression
    Kathryn W Holmes
    Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, 600 N Wolfe St Park 316, Baltimore, MD 21287 2533, USA
    Am J Respir Cell Mol Biol 29:499-505. 2003
    ..These experiments suggest that the mechanism for postnatal reduction of ClC-2 expression in lung epithelia is based on decreased interaction of Sp1 and Sp3 with the ClC-2 promoter...
  59. pmc Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication
    Hiroki Isomura
    Division of Virology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    J Virol 79:9597-607. 2005
    ..These data indicate that the Sp1 and Sp3 binding sites have a significant role in HCMV replication in human fibroblast cells...
  60. ncbi Sp3 expression in immune cells: a quantitative study
    Maria C Grekova
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington DC 20007, USA
    Lab Invest 82:1131-8. 2002
    ..We propose that transcription of the Sp3 gene is blocked in immune cells from most patients with MS and that this contributes to the development of central nervous system inflammation in the disease...
  61. ncbi Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia
    Kiran Singh
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    Indian J Exp Biol 43:1088-92. 2005
    ..Since male infertility is a multifactorial disorder, the contributions of environmental and occupational insults may not be underestimated...
  62. pmc Characterization of the human activator protein-2gamma (AP-2gamma) gene: control of expression by Sp1/Sp3 in breast tumour cells
    Mark D Hasleton
    Cancer Research UK Molecular Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, U K
    Biochem J 373:925-32. 2003
    ..We propose that differences in the level and activity of Sp3 between breast tumour lines can determine the expression level of their AP-2gamma gene...
  63. pmc An Sp1/Sp3 site in the downstream region of varicella-zoster virus (VZV) oriS influences origin-dependent DNA replication and flanking gene transcription and is important for VZV replication in vitro and in human skin
    Mohamed I Khalil
    Department of Microbiology and Immunology, and the Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    J Virol 86:13070-80. 2012
    ..These results suggest that the Sp1/Sp3 site plays an important role in both VZV origin-dependent DNA replication and ORF62 and ORF63 transcription and that, in contrast to HSV, these events are linked during virus replication...
  64. doi The regulation of trefoil factor 2 expression by the transcription factor Sp3
    Jingjing Liu
    Department of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University, Xiamen 361004, Fujian Province, PR China
    Biochem Biophys Res Commun 427:410-4. 2012
    ..On the whole, this study indicated that Sp3 was a major regulator of TFF2 expression. This knowledge should contribute to our understanding of the role that is played by SP3 in the regulation of TFF2 expression...
  65. doi Sp1 and Sp3 transcription factors mediate leptin-induced collagen α1(I) gene expression in primary culture of male rat hepatic stellate cells
    Inmaculada García-Ruiz
    Research Institute, University Hospital 12 de Octubre, School of Medicine, Universidad Complutense, 28041 Madrid, Spain
    Endocrinology 153:5845-56. 2012
    ..These findings may contribute to a better understanding of mechanisms involved in the leptin-induced liver fibrosis...
  66. doi A novel evolutionarily conserved element is a general transcriptional repressor of p21WAF¹/CIP¹
    Weiguo Xu
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
    Cancer Res 72:6236-46. 2012
    ..Taken together, our results revealed, for the first time, this evolutionarily conserved Sp1/Sp3 palindrome element in the proximal p21 promoter that serves as a regulatory repressor to maintain p21 basal level expression...
  67. ncbi [AZF deletions and male infertility]
    Rui Zhi Liu
    Section of Prenatal Diagnosis, Center of Reproductive Medicine, The First Bethune Hospital, Jilin University, Chang Chun, Jilin 130021, China
    Zhonghua Nan Ke Xue 18:963-8. 2012
    ....
  68. doi Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts
    Bahareh Hekmatnejad
    Genetics Unit, Shriners Hospitals for Children Canada, Montreal, Quebec, Canada H3G 1A6
    J Cell Biochem 114:1863-70. 2013
    ..Taken together, our results suggest an interplay between Sp1 and Sp3 as a mechanism involved in the control of Fiat gene expression in osteoblasts...
  69. pmc N6-substituted cAMP analogs inhibit bTREK-1 K+ channels and stimulate cortisol secretion by a protein kinase A-independent mechanism
    Haiyan Liu
    Department of Neuroscience, OSU College of Medicine and Public Health, Columbus, OH, USA
    Mol Pharmacol 76:1290-301. 2009
    ..Finally, although 6-modified cAMP analogs exhibit high selectivity in activating PKA over Epac, they also may interact with other unidentified proteins expressed by eukaryotic cells...
  70. ncbi Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells
    Jaejoon Won
    National Creative Research Initiative Center for Genetic Reprogramming, Institute for Molecular Biology and Genetics, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 277:38230-8. 2002
    ....
  71. pmc HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH)
    James E Boers
    Department of Pathology, Isala Klinieken, Zwolle, The Netherlands
    Histopathology 58:383-94. 2011
    ....
  72. ncbi Screening for Y-chromosome microdeletions in infertile Indian males: utility of simplified multiplex PCR
    Anurag Mitra
    Gamete Antigen Lab, National Institute of Immunology, New Delhi, India
    Indian J Med Res 127:124-32. 2008
    ..Feasibility of developing a simplified multiplex PCR for screening of the Y chromosome microdeletions has been explored...
  73. doi Development of a multiplex quantitative fluorescent PCR assay for identification of rearrangements in the AZFb and AZFc regions
    Jun Zhang
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong 510080, People s Republic of China
    Mol Hum Reprod 14:371-6. 2008
    ..Eleven types of rearrangement in AZFb and AZFc regions were well discriminated with QF-PCR. In conclusion, QF-PCR is a simple and reliable method to detect rearrangements in AZFb and AZFc...
  74. doi Quantitative fluorescent-PCR detection of sex chromosome aneuploidies and AZF deletions/duplications
    Toso Plaseski
    Macedonian Academy of Sciences and Arts, Research Center for Genetic Engineering and Biotechnology, Skopje, Republic of Macedonia
    Genet Test 12:595-605. 2008
    ..We conclude that multiplex QF-PCR is a rapid, simple, reliable, and inexpensive method that can be used as a first-step genetic analysis in infertile/subfertile patients...
  75. ncbi Expression profile of AZF genes in testicular biopsies of azoospermic men
    S E Kleiman
    Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv University, Israel
    Hum Reprod 22:151-8. 2007
    ..This study investigated the expression of several AZF (USP9Y, DDX3Y/DDX3Yt1, EIF1AY and PRY) and USP9X transcripts in testicular biopsies of 89 azoospermic men who had been ..
  76. doi ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells
    Isidora Petrovic
    Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia
    Mol Biol Rep 36:993-1000. 2009
    ..Presented data provide the initial information about transcriptional regulation that will help in better understanding of molecular mechanisms involved in regulation of SOX18 gene expression...
  77. doi Association of Sp3 and estrogen receptor alpha with the transcriptionally active trefoil factor 1 promoter in MCF-7 breast cancer cells
    Lin Li
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Biochem 105:365-9. 2008
    ..Taken together, these results provide evidence that Sp3 and ERalpha are involved in the estrogen induced transcription of the TFF1 gene...
  78. pmc Specificity proteins Sp1 and Sp3 interact with the rat GTP cyclohydrolase I proximal promoter to regulate transcription
    Nitya Sarath Chandran
    Cellular and Clinical Neurobiology Program, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Neurochem 104:1233-48. 2008
    ..These results suggest that Sp1 and Sp3 bound to the GC-box might help to preserve an open chromatin configuration at the proximal promoter in cells which constitutively express low levels of GTP Cyclohydrolase I...
  79. doi Molecular characterization of the DDX3Y gene and its homologs in cattle
    W S Liu
    Department of Dairy and Animal Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Cytogenet Genome Res 126:318-28. 2009
    ....
  80. ncbi SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3095, USA
    Biol Reprod 75:605-14. 2006
    ....
  81. ncbi IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1
    Md Ruhul Amin
    University of Illinois at Chicago, Dept of Medicine, Section of Digestive Diseases and Nutrition, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 291:C887-96. 2006
    ..Our data indicate that IFN-gamma and TNF-alpha may repress the NHE3 promoter activity in C2BBe1 cells by PKA-mediated phosphorylation of Sp1 and Sp3 transcription factors...
  82. ncbi Electrochemical performance of angstrom level flat sputtered carbon film consisting of sp2 and sp3 mixed bonds
    Osamu Niwa
    National Institute of Advanced Industrial Science and Technology, Tskuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Am Chem Soc 128:7144-5. 2006
    ..The ultra-flat surface and low surface oxygen concentration suppress fouling with electroactive species, such as oligonucleotides, NADH, and bisphenol A...
  83. ncbi Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells
    Tomohiro Goto
    Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Bone Miner Res 21:661-73. 2006
    ..The findings indicate both ubiquitous and osteoblast-specific mechanisms of collagen gene regulation...
  84. doi Translational control of the AZFa gene DDX3Y by 5'UTR exon-T extension
    L Jaroszynski
    Unit Molecular Genetics and Fertility Disorders, Department of Gynecological Endocrinology and Fertility Disorders, University Women Hospital, Heidelberg
    Int J Androl 34:313-26. 2011
    ....
  85. doi Estimation of hormone receptor status and HER2 in cytologic cell blocks from breast cancer using the novel rabbit monoclonal antibodies (SP1, SP2, and SP3)
    Aziza Nassar
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55902, USA
    Diagn Cytopathol 37:865-70. 2009
    ..Both are as sensitive as their FDA-approved clones. SP3, on the other hand, is superior to HercepTest for detecting HER2 overexpression, with an excellent concordance with FISH...
  86. ncbi Incidence of microdeletions in the AZF region of the Y chromosome in Slovak patients with azoospermia
    Regina Behulova
    Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 155:33-8. 2011
    ..The aim of this study was to analyze incidence of microdeletions in the AZF region of Y chromosome in patients with azoospermia from Slovakia...
  87. ncbi Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease
    Stephanie Boutillier
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    Neurodegener Dis 4:413-23. 2007
    ..Herein, we investigated the fate of the Sp family of transcription factors in postmortem brains from patients with AD disease and in different contexts of neuronal death...
  88. ncbi The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes
    Nicole Schnur
    Institute of Pharmaceutical Chemistry ZAFES, University of Frankfurt, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Biochim Biophys Acta 1771:1271-82. 2007
    ..This is the first report demonstrating that Sp3 is involved in the regulation of 5-LO promoter activity. In summary, we show that TsA increases 5-LO promoter activity by the enhanced recruitment of Sp1 and Sp3 to the 5-LO promoter...
  89. pmc Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3
    Nina V Fuchs
    Paul Ehrlich Institut, Federal Institute for Vaccines and Biomedicines, Paul Ehrlich Strasse 51 59, D 63225 Langen, Germany
    J Virol 85:3436-48. 2011
    ....
  90. pmc Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3
    Bastian Stielow
    Institute of Molecular Biology and Tumor Research, Philipps University of Marburg, Marburg, Germany
    PLoS Genet 6:e1001203. 2010
    ..Our results establish SUMO conjugation to Sp3 as a molecular beacon for the assembly of repression machineries to maintain tissue-specific transcriptional gene silencing...
  91. ncbi Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk)
    Gilles Pages
    Institute of Signalling, Developmental Biology and Cancer Research UMR CNRS 6543, University of Nice Sophia Antipolis Equipe labellisée Ligue Nationale contre le Cancer, France
    J Cell Physiol 213:454-63. 2007
    ..Altogether our results described a new link between constitutive Erk activity and the regulation of VEGF expression two common denominators implicated in tumor angiogenesis...
  92. pmc Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?
    Paulo Navarro-Costa
    Departamento de Genetica, Instituto Nacional de Saude Dr Ricardo Jorge, 1649 016 Lisboa, Portugal
    J Biomed Biotechnol 2010:936569. 2010
    ..In this regard, evidence supporting the notion that DDX3Y, KDM5D, RBMY1A1, DAZ, and CDY represent key AZF spermatogenic determinants will be discussed...
  93. ncbi Y chromosome haplogroups and susceptibility to testicular cancer
    A Ferlin
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Mol Hum Reprod 13:615-9. 2007
    ....
  94. doi GATA4 regulates ANF expression synergistically with Sp1 in a cardiac hypertrophy model
    Xiaoqing Hu
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
    J Cell Mol Med 15:1865-77. 2011
    ..Thus, our findings revealed the critical interaction of GATA4 and Sp1 in modulating ANF expression, indicating their involvement in cardiac hypertrophy...
  95. ncbi Partial AZFc deletions in infertile men with cryptorchidism
    C Giachini
    Andrology Unit, Department of Clinical Physiopathology, Center for Research, Transfer and Higher Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders, University of Florence, 6 Viale Pieraccini, 50139 Firenze, Italy
    Hum Reprod 22:2398-403. 2007
    ..Since both pathologies can be part of the testicular dysgenesis syndrome (TDS), we aimed to define the role of 'gr/gr' deletion in the aethiopathogenesis of another component of the TDS: cryptorchidism...
  96. ncbi Retinoic acid induced downregulation of MYCN is not mediated through changes in Sp1/Sp3
    Kelli K Kanemaru
    Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, Honolulu, Hawaii, USA
    Pediatr Blood Cancer 50:806-11. 2008
    ..Here, post-translational modifications of Sp proteins were examined as an alternate mechanism of RA-mediated promoter regulation...
  97. ncbi NFkappaB mediates IL-1beta-induced down-regulation of TbetaRII through the modulation of Sp3 expression
    C Bauge
    Laboratory of Connective Tissue Biochemistry, University of Caen, Caen, France
    J Cell Mol Med 12:1754-66. 2008
    ..These findings bring new insights in the knowledge of the interference between two antagonistic transduction pathways involved in multiple physiopathological processes...
  98. ncbi Sp1 and Sp3 regulate basal transcription of the human CYP2F1 gene
    Jie Wan
    Department of Pharmacology and Toxicology, 30 South 2000 East, Room 201, University of Utah, Salt Lake City, UT 84112 5820
    Drug Metab Dispos 33:1244-53. 2005
    ..Thus, these studies demonstrated that four Sp1-dependent proximal promoter elements drive organ-selective CYP2F1 gene transcription, and that Sp1 and Sp3 factors interact to modulate constitutive CYP2F1 transcription in lung cells...
  99. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
    ....
  100. ncbi Down-regulation of human type II collagen gene expression by transforming growth factor-beta 1 (TGF-beta 1) in articular chondrocytes involves SP3/SP1 ratio
    Christos Chadjichristos
    Laboratoire de Biochimie du Tissu Conjonctif, Faculte de Medecine, CHU niveau 3, avenue de Côte de Nacre, 14032, Caen Cedex, France
    J Biol Chem 277:43903-17. 2002
    ..These findings suggest that TGF-beta1 inhibition of COL2A1 gene transcription in RAC is mediated by an increase of the Sp3/Sp1 ratio and by the repression of Sp1 transactivating effects on that gene...
  101. ncbi Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene
    H Ding
    Center for Molecular and Vascular Biology, University of Leuven, 3000 Leuven, Belgium
    J Biol Chem 274:19573-80. 1999
    ..This is the first demonstration of a functional interaction between proteins of the Sp1 and SNF/SWI families...

Research Grants24

  1. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2012
    ....
  2. Transcriptional regulation: renal dopamine D1 receptors in HTN &oxidative stress
    Mustafa F Lokhandwala; Fiscal Year: 2013
    ....
  3. Colon Cell Differentiation: NAB and MUC2 Gene Expression
    Anna Velcich; Fiscal Year: 2009
    ..5. Finally, we will extend our use of microarray technology to determine how NaB perturbs profiles of gene expression that define lineage specific differentiation (Velcich et al., submitted). ..
  4. MECHANISMS OF NA+ TRANSPORT IN THE HUMAN INTESTINE
    Pradeep K Dudeja; Fiscal Year: 2012
    ..Any information derived from studies of these proteins would be of clinical and therapeutic benefit for patients suffering from diarrheal disease processes. ..
  5. Renal Dopamine and Angiotensin II Receptor Function in Age-Related Hypertension
    Mohammad Asghar; Fiscal Year: 2013
    ..These studies should provide a better understanding of the mechanism by which oxidative stress causes hypertension which would subsequently lead to targeted therapy for hypertension. ..
  6. Mechanisms of Neuronal Specific Transcription
    Grace Gill; Fiscal Year: 2009
    ....
  7. INTERFERON ACTION AND PROTEIN PHOSPHORYLATION
    Charles E Samuel; Fiscal Year: 2013
    ..Elucidation of the actions of interferon at the molecular level is of immediate importance in view of the use of interferon in the clinic. ..
  8. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..The last studies are highly significant in their own right, because they will provide novel insights into the mechanisms used by members of two large transcription factor families to stimulate transcription. ..
  9. A Measurement Error Approach to Estimating Usual Daily Physical Activity Distribu
    Greg J Welk; Fiscal Year: 2011
    ..Data analyses will involve the development and evaluation of statistical procedures that calibrate the self-report measure against objective physical data to obtain accurate estimates of "usual" physical activity in the population. ..
  10. Role of Y Chromosome Genes in Spermatogenesis
    Jan Rohozinski; Fiscal Year: 2004
    ..This proposal is designed to build on this progress and produce mice carrying null alleles of Eif2bs3y and Usp9y. These mice will then be used to directly determine the role played by these two Sxr genes in spermatogenesis.
  11. Investigations of New Pd"/Pd"-catalyzed aryl C-F and C-CF3 Coupling Reactions
    NICHOLAS DEWAYNE BALL; Fiscal Year: 2010
    ..We are hopeful that this work will provide practiical synthetic tools in the development of new biologically relevant organofluorine compounds. ..
  12. REGULATION OF MEIOSIS IN SPERMATOGENESIS
    Steven Wasserman; Fiscal Year: 2003
    ..abstract_text> ..
  13. Transition Metal-Catalyzed Chemistry in Water at Room Temperature
    Bruce H Lipshutz; Fiscal Year: 2013
    ..The secret to this success is based on proper engineering of particle size, which better accommodates the intended chemistry. ..
  14. New Methods for Direct Carbon-Hydrogen Bond Functionalization
    OLAFS DAUGULIS; Fiscal Year: 2013
    ..New auxiliary and reaction development for sp3 C-H bond conversion to C-C bonds, 2. Fluorination of unactivated sp3 C-H bonds, 3. Auxiliary assisted, copper-catalyzed C-H bond functionalization. ..
  15. Functionalization of unactivated sp2-hybridized carbon atoms
    Carsten Krebs; Fiscal Year: 2013
    ....
  16. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  17. Synthesis and Study of Dimeric Diketopiperazine Alkaloids
    Mohammad Movassaghi; Fiscal Year: 2013
    ....
  18. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009
    ..The objective of this study is to delineate the molecular mechanisms of PAFAH induction by oxPL in hopes that this will uncover novel mechanisms for regulating the enzyme and thereby controlling cardiovascular disease. ..
  19. Selective C-H Bond Functionalization in Complex Organic Synthesis
    Dalibor Sames; Fiscal Year: 2010
    ..Such research tools will increase the rate of understanding and potential treatment of human diseases. ..
  20. FUNCTIONAL ROLE OF MDAZ IN INFERTILITY
    Megerditch Kiledjian; Fiscal Year: 2002
    ..Understanding how these proteins normally function in sperm production will also provide novel strategies in male contraception. ..
  21. VIMENTINSS REGULATORY FACTORS INVOLVED IN DEVELOPMENT
    ZENDRA ZEHNER; Fiscal Year: 2003
    ..It is hoped that by a thorough understanding of how these genetic controls contribute to development, the investigators can ultimately determine how abnormalities may develop in the heart. ..
  22. Arylation of weakly acidic sp3 hybridized C-H's
    Patrick J Walsh; Fiscal Year: 2013
    ..The two approaches to C-C bond-formation in this application are innovative because they represent a clear departure from known chemistry. ..
  23. Differential Functions of Sp-Family Members
    Jonathan Horowitz; Fiscal Year: 2006
    ..In so doing, we will link specific Sp-family members and their regulators with extracellular signals that govern the synthesis of Sp-dependent genes. ..
  24. MECHANISM OF SUPPRESSION OF SP3 GENE EXPRESSION IN MS
    John Richert; Fiscal Year: 2000
    ..Subsequent studies will determine if these factors/peptides exhibit an inhibitory influence on Sp3 gene transcription. ..