USP9X

Summary

Gene Symbol: USP9X
Description: ubiquitin specific peptidase 9 X-linked
Alias: DFFRX, FAF, FAM, MRX99, MRXS99F, Drosophila fat facets related, X-linked, deubiquitinating enzyme FAF-X, fat facets in mammals, fat facets protein related, X-linked, hFAM, ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila), ubiquitin thioesterase FAF-X, ubiquitin thiolesterase FAF-X, ubiquitin-specific processing protease FAF-X, ubiquitin-specific protease 9, X chromosome
Species: human
Products:     USP9X

Top Publications

  1. Nagai H, Noguchi T, Homma K, Katagiri K, Takeda K, Matsuzawa A, et al. Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. Mol Cell. 2009;36:805-18 pubmed publisher
    ..Here, we identified the deubiquitinating enzyme USP9X as a binding partner of ASK1 that mediates oxidative stress-induced cell death through activation of the JNK and ..
  2. Nathan J, Sengupta S, Wood S, Admon A, Markson G, Sanderson C, et al. The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic. 2008;9:1130-45 pubmed publisher
    ..expression and short interfering RNA depletion experiments demonstrate that MARCH7 can be stabilized by both USP9X and USP7, which deubiquitylate MARCH7 in the cytosol and nucleus, respectively...
  3. Gomez Bougie P, Menoret E, Juin P, Dousset C, Pellat Deceunynck C, Amiot M. Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction. Biochem Biophys Res Commun. 2011;413:460-4 pubmed publisher
    ..Because the USP9X deubiquitinase was recently demonstrated to be involved in Mcl-1 protein turnover by preventing its degradation ..
  4. Schwickart M, Huang X, Lill J, Liu J, Ferrando R, French D, et al. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature. 2010;463:103-7 pubmed publisher
    ..The mechanism of MCL1 overexpression in cancer is not well understood. Here we show that the deubiquitinase USP9X stabilizes MCL1 and thereby promotes cell survival...
  5. Murray R, Jolly L, Wood S. The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin. Mol Biol Cell. 2004;15:1591-9 pubmed
    ..Fat Facets in mouse (FAM) is substrate-specific deubiquitylating enzyme highly expressed in epithelia where it interacts with its substrate, ..
  6. Grou C, Francisco T, Rodrigues T, Freitas M, Pinto M, Carvalho A, et al. Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate. J Biol Chem. 2012;287:12815-27 pubmed publisher
    ..Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liver and HeLa cells...
  7. Peddaboina C, Jupiter D, Fletcher S, Yap J, Rai A, Tobin R, et al. The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition. BMC Cancer. 2012;12:541 pubmed publisher
    ..The Mcl-1, Bcl-xL and USP9X expression patterns in human lung and colon adenocarcinomas were evaluated via immunohistochemistry...
  8. Taya S, Yamamoto T, Kano K, Kawano Y, Iwamatsu A, Tsuchiya T, et al. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J Cell Biol. 1998;142:1053-62 pubmed
    ..The peptide sequences of p220 were identical to the amino acid sequences of mouse Fam. Fam is homologous to a deubiquitinating enzyme in Drosophila, the product of the fat facets gene...
  9. Mouchantaf R, Azakir B, McPherson P, Millard S, Wood S, Angers A. The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X. J Biol Chem. 2006;281:38738-47 pubmed
    ..Using affinity purification coupled to mass spectrometry, we have now identified the ubiquitin-protease FAM/USP9X as a binding partner of Itch...

More Information

Publications121 found, 100 shown here

  1. Al Hakim A, Zagorska A, Chapman L, Deak M, Peggie M, Alessi D. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J. 2008;411:249-60 pubmed publisher
    ..kinase 4), are polyubiquitinated in vivo and interact with the deubiquitinating enzyme USP9X (ubiquitin specific protease-9)...
  2. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009;136:123-35 pubmed publisher
    ..By means of siRNA screen we identified FAM (USP9x), a deubiquitinase acting as essential and evolutionarily conserved component in TGFbeta and bone morphogenetic ..
  3. Han K, Foster D, Zhang N, Kanisha K, Dzieciatkowska M, Sclafani R, et al. Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron. J Biol Chem. 2012;287:43741-52 pubmed publisher
    ..In this report, we find that Usp9x, a deubiquitinating enzyme, stably associates with the SMN complex via directly interacting with SMN...
  4. Homan C, Kumar R, Nguyen L, Haan E, Raymond F, Abidi F, et al. Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth. Am J Hum Genet. 2014;94:470-8 pubmed publisher
    ..X-linked intellectual disability, we identified three unique variants (two missense and one protein truncating) in USP9X. To assess the functional significance of these variants, we took advantage of the Usp9x knockout mouse we ..
  5. Perez Mancera P, Rust A, van der Weyden L, Kristiansen G, Li A, Sarver A, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature. 2012;486:266-70 pubmed publisher
    ..The most commonly mutated gene was the X-linked deubiquitinase Usp9x, which was inactivated in over 50% of the tumours...
  6. Th ard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon E, et al. USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly. EMBO J. 2010;29:1499-509 pubmed publisher
    ..We report here that the deubiquitinating enzyme USP9x has a critical function in TJ biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a ..
  7. Sun H, Kapuria V, Peterson L, Fang D, Bornmann W, Bartholomeusz G, et al. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. 2011;117:3151-62 pubmed publisher
    ..WP1130, but not Bcr-Abl kinase inhibitors, directly inhibits Usp9x deubiquitinase activity, resulting in the down-regulation of the prosurvival protein Mcl-1 and facilitating ..
  8. Dhandhukia J, Li Z, Peddi S, Kakan S, Mehta A, Tyrpak D, et al. Berunda Polypeptides: Multi-Headed Fusion Proteins Promote Subcutaneous Administration of Rapamycin to Breast Cancer In Vivo. Theranostics. 2017;7:3856-3872 pubmed publisher
    ..FSI nanoparticles (Rh ~ 25 nm) and compares them with two second-generation carriers (FA and FAF) that: i) do not self-assemble; ii) retain a hydrodynamic radius (Rh ~ 7 nm) above the renal ..
  9. Bax N, Lambertus S, Cremers F, Klevering B, Hoyng C. The absence of fundus abnormalities in Stargardt disease. Graefes Arch Clin Exp Ophthalmol. 2019;: pubmed publisher
    ..STGD1 diagnosis, best-corrected visual acuity (BCVA), ophthalmoscopy, fundus photography, fundus autofluorescence (FAF), fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), full-field ..
  10. Volkov R, Panchuk I, Borisjuk N, Hosiawa Baranska M, Maluszynska J, Hemleben V. Evolutional dynamics of 45S and 5S ribosomal DNA in ancient allohexaploid Atropa belladonna. BMC Plant Biol. 2017;17:21 pubmed publisher
    ..structure, molecular organization and evolution of ribosomal DNA (rDNA) in nightshade, Atropa belladonna (fam. Solanaceae), one of the oldest known allohexaploids among flowering plants...
  11. Barat A, Sahoo P, Kumar R, Pande V. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Comp Biochem Physiol B Biochem Mol Biol. 2016;200:54-61 pubmed publisher
    ..This study provides the first hand database of solute carrier families particularly transporter encoding proteins in the species. ..
  12. Jiang Y, Jiao Y, Liu Y, Zhang M, Wang Z, Li Y, et al. Sinomenine Hydrochloride Inhibits the Metastasis of Human Glioblastoma Cells by Suppressing the Expression of Matrix Metalloproteinase-2/-9 and Reversing the Endogenous and Exogenous Epithelial-Mesenchymal Transition. Int J Mol Sci. 2018;19: pubmed publisher
    ..et Wils. (Fam. Menispermaceae), initiates the autophagy-mediated death of human glioblastoma cells by generating reactive ..
  13. Kawanishi Y, Nakasa T, Shoji T, Hamanishi M, Shimizu R, Kamei N, et al. Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model. Arthritis Res Ther. 2014;16:488 pubmed publisher
    ..Real-time PCR and immunohistochemical evaluations were performed. Twenty-four hours after the injection, FAM (Fluorescein amidite) labeled miR-210 was observed in the cells around the injured site...
  14. Jabri M, Aissani N, Tounsi H, Sakly M, Marzouki L, Sebai H. Protective effect of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced injury in rat gastric mucosa. Pathophysiology. 2017;24:1-8 pubmed publisher
    ..w.), EtOH+famotidine (FAM) and EtOH+ascorbic acid (AA). Gastric ulceration was induced by EtOH (4g/kg, b.w. p.o.)...
  15. Qin W, Heal K, Ramdasi R, Kobelt J, Martens Habbena W, Bertagnolli A, et al. Nitrosopumilus maritimus gen. nov., sp. nov., Nitrosopumilus cobalaminigenes sp. nov., Nitrosopumilus oxyclinae sp. nov., and Nitrosopumilus ureiphilus sp. nov., four marine ammonia-oxidizing archaea of the phylum Thaumarchaeota. Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..nov., Nitrosopumilus oxyclinae sp. nov., and Nitrosopumilus ureiphilus sp. nov., respectively. In addition, we propose the family Nitrosopumilaceae fam. nov. and the order Nitrosopumilales ord. nov. within the class Nitrososphaeria.
  16. Aya A, Pouchain P, Thomas H, Ripart J, Cuvillon P. Incidence of postoperative delirium in elderly ambulatory patients: A prospective evaluation using the FAM-CAM instrument. J Clin Anesth. 2019;53:35-38 pubmed publisher
    ..Filling of the Family Confusion Assessment Method (FAM-CAM) questionnaire (11 items) during a phone interview of family caregivers on two separate occasions: five to ..
  17. Swanepoel T, Sabbar M, Baartman T, Laburn H, Mitchell D, Dukhan T, et al. Simulated acute central Mycoplasma infections in rats induce fever, anorexia, body mass stunting and lethargy but spare memory. Physiol Behav. 2016;163:294-304 pubmed publisher
    ..central administration of fibroblast-stimulating lipopeptide-1 (FSL-1), derived from Mycoplasma salivarium, and FAM-20 from a more pathogenic species, namely Mycoplasma pneumoniae, on behavioural and inflammatory responses in rats...
  18. Muratoglu H, Nalcacioglu R, Arif B, Demirbag Z. Genome-wide analysis of differential mRNA expression of Amsacta moorei entomopoxvirus, mediated by the gene encoding a viral protein kinase (AMV197). Virus Res. 2016;215:25-36 pubmed publisher
    Insect-born entomopoxviruses (Fam: Poxviridae) are potentially important bio-pesticide against insect pests and expression vectors as well as vectors for transient human gene therapies including recombinant viral vaccines...
  19. Chinasa E, Ifeoma I, Obodoike E, Chhukwuemeka E. Evaluation of anti-inflammatory property of the leaves of Sansevieria liberica ger. and labr. (fam: Dracaenaceae). Asian Pac J Trop Med. 2011;4:791-5 pubmed publisher
    ..Further purification on these bioactive constituents may result in the development of potent anti-inflammatory agent with low toxicity and better therapeutic index. ..
  20. Hakim A, Cooke K, Pavletic S, Khalid M, Williams K, Hashmi S. Diagnosis and treatment of bronchiolitis obliterans syndrome accessible universally. Bone Marrow Transplant. 2019;54:383-392 pubmed publisher
    ..g. fluticasone-azithromycin-montelukast [FAM] combination, etanercept, extra-corporeal photopheresis [ECP], lung transplantation, and prompt treatment of ..
  21. Sarmiento Vizcaíno A, González V, Braña A, Molina A, Acuña J, García L, et al. Myceligenerans cantabricum sp. nov., a barotolerant actinobacterium isolated from a deep cold-water coral. Int J Syst Evol Microbiol. 2015;65:1328-34 pubmed publisher
    An actinobacterium strain (M-201(T)) was isolated from a deep-sea scleractinian coral (Fam. Caryophillidae) collected at 1500 m depth in the Avilés Canyon in the Cantabrian Sea, Asturias, Spain. Strain M-201(T) grew at pH 6.0-9...
  22. Fu Q, Zhang Y, Cheng J, Chen X, Xie J, Luo S. [Function of death associated protein kinase(DAPK) in colorectal cancer chemoresistance]. Zhonghua Wei Chang Wai Ke Za Zhi. 2014;17:1101-5 pubmed
    ..DAPK-siRNA was transfected into cells to down-regulate the DAPK gene expression (DAPK-siRNA grouyp), FAM-siRNA was transfected as control group, and DAPK over-expression plasmid vectors were constructed to up-regulate ..
  23. Zeeshan M, Tyagi K, Sharma Y. CD4+ T cell response correlates with naturally acquired antibodies against Plasmodium vivax tryptophan-rich antigens. Infect Immun. 2015;83:2018-29 pubmed publisher
    ..Plasmodium vivax contains remarkably large numbers of such proteins belonging to the "Pv-fam-a" family that need to be characterized...
  24. Ibaraki H, Kanazawa T, Takashima Y, Okada H, Seta Y. Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide. Molecules. 2016;21: pubmed publisher
    ..times) back skin of mice or AD-like skin of auricles treated with 6-carboxyfluorescein-aminohexyl phosphoramidite (FAM)-labeled siRNA, the tight junction modulator AT1002, and the functional cytoplasm-responsive stearylated peptide ..
  25. Shirole R, Shirole N, Saraf M. Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome. J Ethnopharmacol. 2015;168:356-63 pubmed publisher
    Embelia ribes Burm. f. (Fam. Myrsinaceae) locally known as Vidanga have been used for treating tumors, ascites, bronchitis, jaundice, diseases of the heart and brain in traditional Indian medicine...
  26. Ashkani S, Rafii M, Shabanimofrad M, Foroughi M, Azizia P, Akhtar M, et al. Multiplex SSR-PCR approaches for semi-automated genotyping and characterization of loci linked to blast disease resistance genes in rice. C R Biol. 2015;338:709-22 pubmed publisher
    ..markers related to rice blast resistance genes were fluorescently labelled at the 5'-end with either 6-FAM or HEX using the G5 dye set and incorporated into a multiplex SSR-PCR for the detection of fragments using an ..
  27. Jensen K, Caira J, Cielocha J, Littlewood D, Waeschenbach A. When proglottids and scoleces conflict: phylogenetic relationships and a family-level classification of the Lecanicephalidea (Platyhelminthes: Cestoda). Int J Parasitol. 2016;46:291-310 pubmed publisher
    ..b>fam., Eniochobothriidae n. fam., Paraberrapecidae n. fam., and Zanobatocestidae n. fam.)...
  28. Shamali M, Konradsen H, Lauridsen J, Østergaard B. Translation and validation of the Danish version of the brief family assessment measure III in a sample of acutely admitted elderly medical patients. Scand J Caring Sci. 2017;: pubmed publisher
    ..The Brief Family Assessment Measure Third Edition (Brief FAM-III) is among the most frequently used self-report instruments that measures family functioning...
  29. Grasso D, Ropolo A, Lo Re A, Boggio V, Molejón M, Iovanna J, et al. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. J Biol Chem. 2011;286:8308-24 pubmed publisher
    ..The autophagy-related protein VMP1, the ubiquitin-protease USP9x, and the ubiquitin-binding protein p62 mediate zymophagy...
  30. Labay V. Review of amphipods of the Melita group (Amphipoda: Melitidae) from the costal waters of Sakhalin Island (Far East of Russia). I. Genera Megamoera Bate, 1862 and Armatomelita gen. nov. Zootaxa. 2013;3700:65-112 pubmed
    A review of Melita group (fam. Melitidae) from the shelf of Sakhalin Island based on literature and own data is provided. Based on new material, four new species of the genus Megamoera are described: M. similidentata sp. nov. and M...
  31. Höhn F, Kretz F, Beger I, Koch F, Auffarth G, Singh P, et al. [Half-Dose Verteporfin Photodynamic Therapy (hdPDT) in the Treatment of Central Serous Chorioretinopathy]. Klin Monbl Augenheilkd. 2016;233:860-3 pubmed publisher
    ..Fluorescein angiography (FA), autofluorescence (FAF) and optical coherence tomography (OCT) were measured at each visit...
  32. Pedler A, Kamper S, Sterling M. Addition of posttraumatic stress and sensory hypersensitivity more accurately estimates disability and pain than fear avoidance measures alone after whiplash injury. Pain. 2016;157:1645-54 pubmed publisher
    The fear avoidance model (FAM) has been proposed to explain the development of chronic disability in a variety of conditions including whiplash-associated disorders (WADs)...
  33. Olejko L, Cywiński P, Bald I. An ion-controlled four-color fluorescent telomeric switch on DNA origami structures. Nanoscale. 2016;8:10339-47 pubmed publisher
    ..DNA and G-quadruplex structures using Förster resonance energy transfer (FRET) between the dyes fluorescein (FAM) and cyanine3 (Cy3)...
  34. Turner E, Sikander S, Bangash O, Zaidi A, Bates L, Gallis J, et al. The effectiveness of the peer delivered Thinking Healthy Plus (THPP+) Programme for maternal depression and child socio-emotional development in Pakistan: study protocol for a three-year cluster randomized controlled trial. Trials. 2016;17:442 pubmed publisher
    ..2002; Arch Dis Child 77(2):99-101, 1997; J Pak Med Assoc 60(4):329; J Psychosoma Res 49(3):207-16, 2000; Clin Child Fam Psychol Rev 14(1):1-27, 2011)...
  35. Xu J, Wang Y, Yang L, Gao Y, Li B, Jin Y. A cytometric assay for ultrasensitive and robust detection of human telomerase RNA based on toehold strand displacement. Biosens Bioelectron. 2017;87:1071-1076 pubmed publisher
    ..DNA probes of TSDR are ingeniously designed, including biotinylated hairpin DNA1 (H1) and carboxyfluorescein (FAM)-labeled hairpin DNA2 (F-H2)...
  36. Khakbaz F, Mahani M. Micro-RNA detection based on fluorescence resonance energy transfer of DNA-carbon quantum dots probes. Anal Biochem. 2017;523:32-38 pubmed publisher
    ..The fluorescence quantum yield of the synthesized dots was determined using quinine sulfate as the standard. The FAM-labeled single stranded DNA, as sensing element, was adsorbed on dots by ?-? interaction...
  37. Dumack K, Mausbach P, Hegmann M, Bonkowski M. Polyphyly in the Thecate Amoeba Genus Lecythium (Chlamydophryidae, Tectofilosida, Cercozoa), Redescription of its Type Species L. hyalinum, Description of L. jennyae sp. nov. and the Establishment of Fisculla gen. nov. and Fiscullidae fam. nov. Protist. 2017;168:294-310 pubmed publisher
    ..We untangle this polyphyly by establishing Fisculla gen. nov. and the Fiscullidae fam. nov. for the former of these two clades.
  38. Vogt D, Bottoni F, Priglinger S, Schumann R. [Lamellar macular holes with hyporeflective epiretinal proliferation : OCT diagnostics and clinical course]. Ophthalmologe. 2017;114:1100-1109 pubmed publisher
    ..The correlation of SD-OCT and en-face OCT can help to identify LMH subgroups and morphology progression early on. FAF enables detection of structural changes at a subclinical stage without visual deterioration...
  39. Gao X, Cui R, Ji G, Liu Z. Size and surface controllable metal-organic frameworks (MOFs) for fluorescence imaging and cancer therapy. Nanoscale. 2018;10:6205-6211 pubmed publisher
    ..covalent grafting the targeting reagent folic acid (FA) and the fluorescence imaging agent 5-carboxyfluorescein (5-FAM), UIO-66-NH2-FA-5-FAM/5-FU can target the cancer cells HePG-2 and display excellent fluorescence imaging in vitro...
  40. You J, Pickart C. A HECT domain E3 enzyme assembles novel polyubiquitin chains. J Biol Chem. 2001;276:19871-8 pubmed
  41. Agrawal P, Chen Y, Schilling B, Gibson B, Hughes R. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). J Biol Chem. 2012;287:21164-75 pubmed publisher
    ..In this study we identify a novel mTOR interacting protein, the ubiquitin-specific protease USP9X, which acts as a negative regulator of mTOR activity and muscle differentiation...
  42. Carvalho L, Remuzgo C, Perez K, Machini M. Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide. Biochim Biophys Acta. 2015;1848:3140-9 pubmed publisher
    ..For the first time, this peptide, its all-D analogue (D-Hb40-61a) and its fluorescently labeled analogue (FAM-Hb40-61a) were successfully assembled on resin at 60°C using conventional heating in all steps...
  43. Kharitidi D, Apaja P, Manteghi S, Suzuki K, Malitskaya E, Roldan A, et al. Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Rep. 2015;13:599-609 pubmed publisher
    ..from integrin α5β1 in vitro and in early endosomes, promoting receptor complex deubiquitination by the USP9x and recycling to the cell surface...
  44. Spinella J, Cassart P, Richer C, Saillour V, Ouimet M, Langlois S, et al. Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations. Oncotarget. 2016;7:65485-65503 pubmed publisher
    ..V167fs, splice site mutation g.chrX:70339329T>C, missense mutation p.R1989H) and USP9X (nonsense mutation p.Q117*)...
  45. Labay V. Review of amphipods of the Melita group (Amphipoda: Melitidae) from the coastal waters of Sakhalin Island (Far East of Russia). III. Genera Abludomelita Karaman, 1981 and Melita Leach, 1814. Zootaxa. 2016;4156:1-73 pubmed publisher
    ..nov. are described and removed from the composition of the genus Melita. A review of Melita group (fam. Melitidae) from the shelf of Sakhalin Island based on all literature and own data is provided...
  46. Domalpally A, Clemons T, Danis R, Sadda S, Cukras C, Toth C, et al. Peripheral Retinal Changes Associated with Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research. Ophthalmology. 2017;124:479-487 pubmed publisher
    ..Participants from prospective studies. The 200° pseudocolor and fundus autofluorescence (FAF) images were captured on the Optos 200 Tx Ultrawide-field device (Optos, Dunfermline, Scotland) by centering on the ..
  47. Meyerovich K, Violato N, Fukaya M, Dirix V, Pachera N, Marselli L, et al. MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic ?-Cells. Diabetes. 2017;66:2446-2458 pubmed publisher
    ..We found that the kinase GSK3?, the E3 ligases MULE and ?TrCP, and the deubiquitinase USP9x regulate cytokine-mediated MCL-1 protein turnover in rodent ?-cells...
  48. Ali Z, Shields C, Jasani K, Aslam T, Balaskas K. Swept-Source Optical Coherence Tomography Angiography Findings in Torpedo Maculopathy. Ophthalmic Surg Lasers Imaging Retina. 2017;48:932-935 pubmed publisher
    ..to assess cases of torpedo maculopathy, including optical coherence tomography (OCT) and fundus autofluorescence (FAF). OCT angiography (OCTA) offers combined structural and flow characteristics of imaged lesions...
  49. Furutani Y, Ogino K, Oishi A, Gotoh N, Makiyama Y, Oishi M, et al. Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited Retinal Dystrophy. Adv Exp Med Biol. 2016;854:299-305 pubmed publisher
    To examine the similarity of wide-field fundus autofluorescence (FAF) imaging in inherited retinal dystrophy between siblings and between parents and their children...
  50. Verbakel S, van Huet R, Boon C, den Hollander A, Collin R, Klaver C, et al. Non-syndromic retinitis pigmentosa. Prog Retin Eye Res. 2018;66:157-186 pubmed publisher
    ..Optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging show a progressive loss of outer retinal layers and altered lipofuscin distribution in a characteristic ..
  51. Dumack K, Mylnikov A, Bonkowski M. Evolutionary Relationship of the Scale-Bearing Kraken (incertae sedis, Monadofilosa, Cercozoa, Rhizaria): Combining Ultrastructure Data and a Two-Gene Phylogeny. Protist. 2017;168:362-373 pubmed publisher
    ..98 PP/63 BP. Based on the unique features of Kraken we establish the Krakenidae fam. nov. that we, due to contradictory results in morphology and phylogeny, assign incertae sedis, Monadofilosa.
  52. Paiva C, Siquelli F, Santos H, Costa M, Massaro D, Lacerda D, et al. The Functionality Assessment Flowchart (FAF): a new simple and reliable method to measure performance status with a high percentage of agreement between observers. BMC Cancer. 2015;15:501 pubmed publisher
    ..to evaluate the inter-observer reliability and construct validity of the new Functionality Assessment Flowchart (FAF) and compare it with ECOG PS and KPS in a sample of cancer patients...
  53. Gilgun J, Anderson G. Mothers' Experiences with Pastoral Care in Cases of Child Sexual Abuse. J Relig Health. 2016;55:680-94 pubmed publisher
    ..In addition, the research responds to Mahoney's (J Marriage Fam 72:805-827, 2010) observations about the scarcity of knowledge on whether religion helps or harms families during ..
  54. Verhelle A, Van Overbeke W, Peleman C, De Smet R, Zwaenepoel O, Lahoutte T, et al. Non-Invasive Imaging of Amyloid Deposits in a Mouse Model of AGel Using 99mTc-Modified Nanobodies and SPECT/CT. Mol Imaging Biol. 2016;18:887-897 pubmed
    Gelsolin amyloidosis (AGel), also known as familial amyloidosis, Finnish type (FAF), is an autosomal, dominant, incurable disease caused by a point mutation (G654A/T) in the gelsolin (GSN) gene...
  55. Liu R, Liu Y, Meng J, Zhu H, Zhang X. A microfluidics-based mobility shift assay to identify new inhibitors of β-secretase for Alzheimer's disease. Anal Bioanal Chem. 2017;409:6635-6642 pubmed publisher
    ..First, the BACE1 activity assay was established with a new fluorescent peptide substrate (FAM-EVNLDAEF) derived from the Swedish mutant APP, and high-quality ratiometric data were generated in both endpoint ..
  56. Liang L, Hu J, Du W, Zuo K, Liu W, Gou X. [Molecular recognition mechanism and motion of HCV NS3/4A protease with Faldaprevir analogue]. Sheng Wu Gong Cheng Xue Bao. 2016;32:669-682 pubmed publisher
    Faldaprevir analogue molecule (FAM) has been reported to effectively inhibit the catalytic activity of HCV NS3/4A protease, making it a potential lead compound against HCV...
  57. Sheikh S, Thulin M, Cavender J, Escalante R, Kawakami S, Lado C, et al. A New Classification of the Dictyostelids. Protist. 2018;169:1-28 pubmed publisher
    ..of these orders are recognized and given the rank of family as, respectively, Acytosteliaceae and Cavenderiaceae fam. nov. in Acytosteliales, and Dictyosteliaceae and Raperosteliaceae fam. nov. in Dictyosteliales...
  58. Ritter M, Zotter S, Schmidt W, Bittner R, Deak G, Pircher M, et al. Characterization of stargardt disease using polarization-sensitive optical coherence tomography and fundus autofluorescence imaging. Invest Ophthalmol Vis Sci. 2013;54:6416-25 pubmed publisher
    ..in Stargardt disease (STGD) based on imaging with polarization-sensitive spectral-domain optical coherence tomography (PS-OCT) and to compare structural changes with those visible on blue light fundus autofluorescence (FAF) imaging.
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    ..sexual-stage antigen s16 (PVX_000930); early transcribed membrane protein (PVX_090230); tryptophan-rich antigen (Pv-fam-a) (PVX_092995); apical merozoite antigen 1 (PVX_092275); and proteins of unknown function (PVX_081830, PVX_117680, ..
  60. Walter D. A new genus and family of sejine mites (Acari, Parasitiformes, Mesostigmata, Sejoidea) based on new species from Lord Howe Island and Brazil, and a redescription of Sejus americanus (Banks, 1902). Zootaxa. 2013;3691:301-23 pubmed
    ..nov.) and one from Bahia State, Brazil (R. braziliensis sp. nov.) and erect a new family, Reginacharlottiidae fam. nov. to accommodate them...
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    ..of FNP which combines an effective facial landmark estimation (FLE) algorithm and facial asymmetrical feature (FAF) by processing facial movement image. The facial landmarks can be detected automatically and accurately using FLE...
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    ..4 and Yq11.2 respectively. These two loci have been termed DFFRX and DFFRY for Drosophila fat facets related X and Y...
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    The purpose of this study was to describe fundus autofluorescence (FAF) findings in eyes with birdshot chorioretinitis (BSCR) and to compare findings to demographic, medical, and clinical characteristics...
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    ..HB-EGF is implicated in DSBs repair as silencing of HB-EGF increased γH2AX foci half-life as well as USP9X expression, two features that could be linked to the observed effect on Mcl-1...
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    ..the programme is housed within the Medical School as part of the Frankfurter Arbeitsstelle für Medizindidaktik (FAM)...
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    ..Last, we showed that ubiquitin variants can bind selectively to ubiquitin-binding domains. Ubiquitin variants exhibit selective function in cells and thus enable orthogonal modulation of specific enzymatic steps in the ubiquitin system. ..
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    ..We report that ubiquitin-specific protease 9X (USP9X), which is a deubiquitinase binds and promotes degradation of both wild-type and mutants of pVHL that retain E3 ..
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    To characterize and correlate the different patterns of fundus autofluorescence (FAF) in patients with birdshot chorioretinopathy (BSCR), with functional and anatomical parameters...
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    ..Here, we applied a non-invasive method to monitor fecal androgen metabolite (fAM) levels in free-ranging giraffe bulls over a period of months to examine longitudinal patterns of androgen ..
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    ..Analysis retrieved five major robust clades that correspond to families Luciferidae, Sergestidae, Acetidae fam.n., Sicyonellidae fam.n. and Petalidiumidae fam.n...
  82. Chou C, Hwang G, Hageman D, Han L, Agrawal P, Pisitkun T, et al. Identification of UT-A1 and AQP2 interacting proteins in rat inner medullary collecting duct. Am J Physiol Cell Physiol. 2017;:ajpcell.00082.2017 pubmed publisher
    ..phosphorylation (protein kinases Cdc42bpb, Phkb, Camk2d and Mtor), ubiquitylation/deubiquitylation (Uba1, Usp9x), and neddylation (Nae1 and Uba3)...
  83. Kuhlmann M, Hamming J, Voldum A, Tsakiridou G, Larsen M, Schmøkel J, et al. An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications. Mol Ther Nucleic Acids. 2017;9:284-293 pubmed publisher
    ..shift assays demonstrated successful annealing of complementary strands bearing Atto488, 6-carboxyfluorescein (6-FAM), or a factor IXa aptamer to the albumin-oligodeoxynucleotide conjugate...
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    ..Comprehensive ophthalmic examination, full-field and pattern electroretinograms, and fundus autofluorescence (FAF) imaging were performed on all patients...
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    ..Moreover, BAG3 was found to positively regulate Mcl-1 levels by binding to and inhibiting USP9X. Our data show that BAG3 and Mcl-1 are key mediators of resistance to chemotherapy in ovarian cancer...
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    ..Clinical data, including age, visual acuity, dilated fundus exam, fundus photos, fundus autofluorescence (FAF), optical coherence tomography, full-field electroretinograms (ERGs), and results of genetic testing, were ..
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    ..and negatively charged NMOFs exhibited totally opposite fluorescence quenching properties toward negatively charged FAM-labeled double-stranded DNA (dsDNA)...
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    Purpose Measuring the predictive value of the Fear-Avoidance Model (FAM) on lifting tasks in Functional Capacity Evaluation (FCE), and on reasons for stopping the evaluation (safe maximal effort, versus self-limited)...
  89. Stachelska M. Detection of Yersinia Enterocolitica Species in Pig Tonsils and Raw Pork Meat by the Real-Time Pcr and Culture Methods. Pol J Vet Sci. 2017;20:477-484 pubmed publisher
    ..The probe was labelled at the 5' end with the fluorescent reporter dye (FAM) and at the 3' end with the quencher dye (TAMRA). The real-time PCR cycling parameters included 41 cycles...
  90. Johansen L, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008;121:854-64 pubmed publisher
    ..These results provide evidence for the role of the cytosolic interactions of IKAP in cell adhesion and migration, and support the notion that cell-motility deficiencies could contribute to FD. ..
  91. Toto L, Di Antonio L, Mastropasqua R, Mattei P, Carpineto P, Borrelli E, et al. Multimodal Imaging of Macular Telangiectasia Type 2: Focus on Vascular Changes Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016;57:OCT268-76 pubmed publisher
    ..angiography (OCTA) and to compare these findings to fundus fluorescein angiography (FFA), fundus autofluorescence (FAF), confocal blue reflectance (CBR), and spectral-domain OCT (SD-OCT)...
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    ..their thresholds differed, both motor and perceptual responses were elicited by small frequency altered feedback (FAF) perturbations...