USP7

Summary

Gene Symbol: USP7
Description: ubiquitin specific peptidase 7
Alias: HAUSP, TEF1, ubiquitin carboxyl-terminal hydrolase 7, Herpes virus-associated ubiquitin-specific protease, deubiquitinating enzyme 7, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific protease 7 (herpes virus-associated), ubiquitin thioesterase 7, ubiquitin-specific-processing protease 7
Species: human
Products:     USP7

Top Publications

  1. Everett R, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J. A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J. 1997;16:566-77 pubmed
    ..These results identify a novel, transitory component of ND10 and implicate a previously uncharacterized ubiquitin-dependent pathway in the control of viral gene expression. ..
  2. Hu M, Gu L, Li M, Jeffrey P, Gu W, Shi Y. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol. 2006;4:e27 pubmed
    Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important ..
  3. Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith C, et al. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol. 2006;13:285-91 pubmed
    The ubiquitin-specific protease, USP7, has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2...
  4. Tang J, Qu L, Zhang J, Wang W, Michaelson J, Degenhardt Y, et al. Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 2006;8:855-62 pubmed
    ..Daxx simultaneously binds to Mdm2 and the deubiquitinase Hausp, and it mediates the stabilizing effect of Hausp on Mdm2...
  5. Kessler B, Fortunati E, Melis M, Pals C, Clevers H, Maurice M. Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. J Proteome Res. 2007;6:4163-72 pubmed
    ..To investigate the biological role of the herpes virus-associated ubiquitin-specific protease HAUSP/USP7, we have generated stably transfected cells carrying inducible shRNA expression plasmids...
  6. Boutell C, Canning M, Orr A, Everett R. Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. J Virol. 2005;79:12342-54 pubmed
    ..ICP0 also interacts very strongly with the cellular ubiquitin-specific protease USP7 (also known as HAUSP)...
  7. Li M, Chen D, Shiloh A, Luo J, Nikolaev A, Qin J, et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002;416:648-53 pubmed
    ..affinity-purified p53-associated factors, we have identified herpesvirus-associated ubiquitin-specific protease (HAUSP) as a novel p53-interacting protein...
  8. Lee H, Kim M, Kim Y, Oh Y, Baek K. HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized. FEBS Lett. 2005;579:4867-72 pubmed
    ..However, p53 is stabilized by the HAUSP (Herpes-virus-associated ubiquitin-specific protease) deubiquitinating enzyme...
  9. Daubeuf S, Singh D, Tan Y, Liu H, Federoff H, Bowers W, et al. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009;113:3264-75 pubmed publisher
    ..This process depends on ICP0-mediated translocation of USP7 (HAUSP) from the nucleus to cytoplasm...

More Information

Publications68

  1. Marchenko N, Wolff S, Erster S, Becker K, Moll U. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J. 2007;26:923-34 pubmed
    ..Upon arrival at the mitochondria, our data suggest that p53 undergoes rapid deubiquitylation by mitochondrial HAUSP via a stress-induced mitochondrial p53-HAUSP complex...
  2. Khoronenkova S, Dianova I, Ternette N, Kessler B, Parsons J, Dianov G. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell. 2012;45:801-13 pubmed publisher
    The deubiquitylation enzyme USP7/HAUSP plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response...
  3. Zapata J, Pawlowski K, Haas E, Ware C, Godzik A, Reed J. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J Biol Chem. 2001;276:24242-52 pubmed
    ..bioinformatics approaches, including: MUL, the product of the causative gene in Mulibrey Nanism syndrome; USP7 (HAUSP), an ubiquitin protease; and SPOP, a POZ domain-containing protein...
  4. D ANDREA A, Pellman D. Deubiquitinating enzymes: a new class of biological regulators. Crit Rev Biochem Mol Biol. 1998;33:337-52 pubmed
    ..Here we explore the structural and biochemical properties of deubiquitinating enzymes and their emerging roles as cellular switches. ..
  5. Holowaty M, Sheng Y, Nguyen T, Arrowsmith C, Frappier L. Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. J Biol Chem. 2003;278:47753-61 pubmed
    USP7 or HAUSP is a ubiquitin-specific protease in human cells that regulates the turnover of p53 and is bound by at least two viral proteins, the ICP0 protein of herpes simplex type 1 and the EBNA1 protein of Epstein-Barr virus...
  6. Schwertman P, Lagarou A, Dekkers D, Raams A, van der Hoek A, Laffeber C, et al. UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nat Genet. 2012;44:598-602 pubmed publisher
    ..the TC-NER master organizing protein ERCC6 (also known as CSB) by delivering the deubiquitinating enzyme USP7 to TC-NER complexes...
  7. Fernandez Montalvan A, Bouwmeester T, Joberty G, Mader R, Mahnke M, Pierrat B, et al. Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization. FEBS J. 2007;274:4256-70 pubmed
    Ubiquitin specific protease 7 (USP7) belongs to the family of deubiquitinating enzymes...
  8. Faesen A, Dirac A, Shanmugham A, Ovaa H, Perrakis A, Sixma T. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Mol Cell. 2011;44:147-59 pubmed publisher
    The ubiquitin-specific protease USP7/HAUSP regulates p53 and MDM2 levels, and cellular localization of FOXO4 and PTEN, and hence is critically important for their role in cellular processes...
  9. Qing P, Han L, Bin L, Yan L, Ping W. USP7 regulates the stability and function of HLTF through deubiquitination. J Cell Biochem. 2011;112:3856-62 pubmed publisher
    ..Here, we identified the deubiquitylating enzyme ubiquitin-specific protease 7 (USP7) as a novel regulator of HLTF stability...
  10. Fei J, Chen J. KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem. 2012;287:35118-26 pubmed publisher
    ..Together, our data not only reveal that KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome. ..
  11. Sarkari F, Sanchez Alcaraz T, Wang S, Holowaty M, Sheng Y, Frappier L. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog. 2009;5:e1000624 pubmed publisher
    ..binding to its recognition sites in vitro is greatly stimulated by binding to the cellular deubiquitylating enzyme, USP7, and that USP7 can form a ternary complex with DNA-bound EBNA1...
  12. Oh Y, Yoo S, Seol J. Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity. Biochem Biophys Res Commun. 2007;357:615-9 pubmed
    ..In this study, we identified USP7 (also known as HAUSP), which is a member of a family of proteins that cleave polyubiquitin chains and/or ubiquitin precursors, as an ..
  13. Song M, Salmena L, Carracedo A, Egia A, Lo Coco F, Teruya Feldstein J, et al. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature. 2008;455:813-7 pubmed publisher
    ..action of a previously unknown PTEN-deubiquitinylating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), and that the integrity of this molecular framework is required for PTEN to be able to enter ..
  14. Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, et al. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal. 2010;3:ra80 pubmed publisher
    ..In contrast, DNMT1 was stabilized by histone deacetylase 1 (HDAC1) and the deubiquitinase HAUSP (herpes virus-associated ubiquitin-specific protease)...
  15. Ma H, Chen H, Guo X, Wang Z, Sowa M, Zheng L, et al. M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A. 2012;109:4828-33 pubmed publisher
    ..However, regulation of UHRF1 is largely unknown. Here we show that the deubiquitylase USP7 interacts with UHRF1...
  16. Sivachandran N, Cao J, Frappier L. Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. J Virol. 2010;84:11113-23 pubmed publisher
    ..The binding of EBNA1 to the host ubiquitin specific protease USP7 has also been shown to be important for EBNA1-mediated PML disruption...
  17. Jäger W, Santag S, Weidner Glunde M, Gellermann E, Kati S, Pietrek M, et al. The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA. J Virol. 2012;86:6745-57 pubmed publisher
    ..We show that LANA interacts with the ubiquitin-specific protease USP7 through its N-terminal TRAF (tumor necrosis factor [TNF] receptor-associated factor) domain...
  18. Faustrup H, Bekker Jensen S, Bartek J, Lukas J, Mailand N. USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. J Cell Biol. 2009;184:13-9 pubmed publisher
    ..Here, we identify the deubiquitylating enzyme ubiquitin-specific protease 7 (USP7) as a novel regulator of Claspin stability...
  19. Nathan J, Sengupta S, Wood S, Admon A, Markson G, Sanderson C, et al. The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic. 2008;9:1130-45 pubmed publisher
    ..and associates with two deubiquitylating enzymes - ubiquitin-specific protease (USP)9X in the cytosol and USP7 in the nucleus...
  20. Becker K, Marchenko N, Palacios G, Moll U. A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. Cell Cycle. 2008;7:1205-13 pubmed
    The protease HAUSP is a critical component of the p53-Mdm2 pathway and acts as a specific deubiquitinase for both p53 and Mdm2 and thus is important for p53 regulation...
  21. Colleran A, Collins P, O Carroll C, Ahmed A, Mao X, McManus B, et al. Deubiquitination of NF-?B by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci U S A. 2013;110:618-23 pubmed publisher
    ..We have identified the deubiquitinase Ubiquitin Specific Protease-7 (USP7) as a regulator of NF-?B transcriptional activity. USP7 deubiquitination of NF-?B leads to increased transcription...
  22. Yuan J, Luo K, Zhang L, Cheville J, Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 2010;140:384-96 pubmed publisher
    ..These findings reveal USP10 to be a novel regulator of p53, providing an alternative mechanism of p53 inhibition in cancers with wild-type p53. ..
  23. Zhang X, Horibata K, Saijo M, Ishigami C, Ukai A, Kanno S, et al. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat Genet. 2012;44:593-7 pubmed publisher
    ..The UVSSA protein forms a complex with USP7 (ref. 8), stabilizes ERCC6 and restores the hypophosphorylated form of RNA polymerase II after UV irradiation.
  24. Sivachandran N, Sarkari F, Frappier L. Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. PLoS Pathog. 2008;4:e1000170 pubmed publisher
    ..PML disruption by EBNA1 requires binding to the cellular ubiquitin specific protease, USP7 or HAUSP, but is independent of p53...
  25. Everett R, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J. A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J. 1997;16:1519-30 pubmed
    ..These results identify a novel, transitory component of ND10 and implicate a previously uncharacterized ubiquitin-dependent pathway in the control of viral gene expression. ..
  26. van der Horst A, de Vries Smits A, Brenkman A, van Triest M, van den Broek N, Colland F, et al. FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol. 2006;8:1064-73 pubmed
    ..Deubiquitination of FOXO requires the deubiquitinating enzyme USP7/HAUSP (herpesvirus-associated ubiquitin-specific protease), which interacts with and deubiquitinates FOXO in response to ..
  27. Saridakis V, Sheng Y, Sarkari F, Holowaty M, Shire K, Nguyen T, et al. Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol Cell. 2005;18:25-36 pubmed
    USP7/HAUSP is a key regulator of p53 and Mdm2 and is targeted by the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV)...
  28. Epping M, Meijer L, Krijgsman O, Bos J, Pandolfi P, Bernards R. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol. 2011;13:102-8 pubmed publisher
    ..with ubiquitin-specific protease 7 (USP7; also known as herpesvirus-associated ubiquitin-specific protease; HAUSP)...
  29. Huang Z, Wu Q, Guryanova O, Cheng L, Shou W, Rich J, et al. Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Nat Cell Biol. 2011;13:142-52 pubmed publisher
    ..However, reciprocal mechanisms that stabilize REST in NPCs are undefined. Here we show that the deubiquitylase HAUSP counterbalances REST ubiquitylation and prevents NPC differentiation...
  30. Huang Z, Zhou W, Bao S. Role of deubiquitylase HAUSP in stem cell maintenance. Cell Cycle. 2011;10:1182-3 pubmed
  31. Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, et al. A strategy for modulation of enzymes in the ubiquitin system. Science. 2013;339:590-5 pubmed publisher
    ..Last, we showed that ubiquitin variants can bind selectively to ubiquitin-binding domains. Ubiquitin variants exhibit selective function in cells and thus enable orthogonal modulation of specific enzymatic steps in the ubiquitin system. ..
  32. Maertens G, El Messaoudi Aubert S, Elderkin S, Hiom K, Peters G. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010;29:2553-65 pubmed publisher
    ..Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify with human PRC1-type complexes through direct interactions with the Psc orthologues MEL18 and ..
  33. Canning M, Boutell C, Parkinson J, Everett R. A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. J Biol Chem. 2004;279:38160-8 pubmed
    ..However, ICP0 binds strongly to the cellular ubiquitin-specific protease USP7, a member of a family of proteins that cleave polyubiquitin chains and/or ubiquitin precursors...
  34. Nicholson B, Suresh Kumar K. The multifaceted roles of USP7: new therapeutic opportunities. Cell Biochem Biophys. 2011;60:61-8 pubmed publisher
    The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators...
  35. Song M, Song S, Kim S, Oh H, Lim D. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008;27:1863-74 pubmed publisher
    ..protein (DAXX) in the nucleus, thereby disrupting the interactions between MDM2, DAXX, and the deubiquitinase, HAUSP, and enhancing the self-ubiquitin ligase activity of MDM2...
  36. Cummins J, Rago C, Kohli M, Kinzler K, Lengauer C, Vogelstein B. Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature. 2004;428:1 p following 486 pubmed
  37. Meulmeester E, Maurice M, Boutell C, Teunisse A, Ovaa H, Abraham T, et al. Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell. 2005;18:565-76 pubmed
    ..COP1, and Pirh2) and the ubiquitin protease activity of the Herpes virus-associated ubiquitin-specific protease (HAUSP) determines the half-life of p53...
  38. Felle M, Joppien S, Nemeth A, Diermeier S, Thalhammer V, Dobner T, et al. The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res. 2011;39:8355-65 pubmed publisher
    ..In this study, we identified USP7 as an interaction partner of Dnmt1 and UHRF1 in vivo...
  39. Li M, Brooks C, Kon N, Gu W. A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell. 2004;13:879-86 pubmed
    Our previous study showed that ubiquitination of p53 is reversible and that the ubiquitin hydrolase HAUSP can stabilize p53 by deubiquitination...
  40. Holowaty M, Zeghouf M, Wu H, Tellam J, Athanasopoulos V, Greenblatt J, et al. Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. J Biol Chem. 2003;278:29987-94 pubmed
    ..We discovered several new specific cellular protein interactions with EBNA1, including interactions with HAUSP/USP7, NAP1, template-activating factor-I beta/SET, CK2, and PRMT5, all of which play important cell regulatory ..
  41. Yang Z, Huo S, Shan Y, Liu H, Xu Y, Yao K, et al. STAT3 repressed USP7 expression is crucial for colon cancer development. FEBS Lett. 2012;586:3013-7 pubmed publisher
    ..Here, we show that expression of ubiquitin-specific protease 7 (USP7), a deubiquitylating enzyme, is decreased in STAT3-positive tumors...
  42. Brooks C, Li M, Hu M, Shi Y, Gu W. The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP. Oncogene. 2007;26:7262-6 pubmed
    The ubiquitin-specific protease HAUSP is a critical component of the p53-Mdm2 pathway by acting as a specific deubiquitinase for both p53 and Mdm2...
  43. Antrobus R, Boutell C. Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0. Virus Res. 2008;137:64-71 pubmed publisher
    ..ICP0 counteracts this activity by recruiting the cellular ubiquitin-specific protease USP7/HAUSP. Here we show that ICP0 can also interact with a previously unidentified isoform of USP7 (termed here USP7(beta))...
  44. Cheng C, Niu C, Yang Y, Wang Y, Lu M. Expression of HAUSP in gliomas correlates with disease progression and survival of patients. Oncol Rep. 2013;29:1730-6 pubmed publisher
    The human herpesvirus-associated ubiquitin-specific protease (HAUSP) deubiquitinating enzyme has been shown to regulate many proteins involved in the cell cycle, as well as tumor suppressors and oncogenes...
  45. van der Knaap J, Kumar B, Moshkin Y, Langenberg K, Krijgsveld J, Heck A, et al. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol Cell. 2005;17:695-707 pubmed
    ..Here, we show that the essential Drosophila ubiquitin-specific protease 7 (USP7) contributes to epigenetic silencing of homeotic genes by Polycomb (Pc)...
  46. Tang J, Qu L, Pang M, Yang X. Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Res Commun. 2010;393:542-5 pubmed publisher
    ..studies, we have found that Daxx forms a complex with the E3 ubiquitin ligase Mdm2 and the de-ubiquitinase Hausp. In the present work, we show that Daxx is ubiquitinated by Mdm2 in both in vitro and in vivo systems and Mdm2 ..
  47. Hu M, Li P, Li M, Li W, Yao T, Wu J, et al. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell. 2002;111:1041-54 pubmed
    ..b>HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53...
  48. Liu X, Groenewald M, Boekhout T, Bai F. Heitmania gen. nov., a new yeast genus in Microbotryomycetes, and description of three novel species: Heitmania litseae sp. nov., Heitmania castanopsis sp. nov. and Heitmania elacocarpi sp. nov. Int J Syst Evol Microbiol. 2017;67:4534-4540 pubmed publisher
    ..gene, the two subunits of the RNA polymerase II gene (RPB1 and RPB2) and the translation elongation factor 1-? (TEF1)...
  49. Laraba I, Boureghda H, Abdallah N, Bouaicha O, Obanor F, Moretti A, et al. Population genetic structure and mycotoxin potential of the wheat crown rot and head blight pathogen Fusarium culmorum in Algeria. Fungal Genet Biol. 2017;103:34-41 pubmed publisher
    ..Morphological identification of the isolates (n FCR=110, n FHB=30) was confirmed by sequencing a portion of TEF1. To assess mating type idiomorph, trichothecene chemotype potential and global population structure, the Algerian ..
  50. Hao Y, Fountain M, Fon Tacer K, Xia F, Bi W, Kang S, et al. USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder. Mol Cell. 2015;59:956-69 pubmed publisher
    ..Here, we show that the USP7 deubiquitinating enzyme is an integral component of the MAGE-L2-TRIM27 ligase and is essential for WASH-mediated ..
  51. de Bie P, Zaaroor Regev D, Ciechanover A. Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochem Biophys Res Commun. 2010;400:389-95 pubmed publisher
    ..Here we identify USP7 as a deubiquitinating enzyme that regulates the ubiquitination state of RING1B...
  52. Zhu Q, Sharma N, He J, Wani G, Wani A. USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168. Cell Cycle. 2015;14:1413-25 pubmed publisher
    ..g. BRCA1 and 53BP1. Here, we report USP7 deubiquitinase regulates the stability of RNF168...
  53. Liu T, Yu J, Deng M, Yin Y, Zhang H, Luo K, et al. CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nat Commun. 2017;8:13923 pubmed publisher
    ..Overall, our study establishes the CDK4/6-DUB3 axis as an important regulatory mechanism of breast cancer metastasis and provides a rationale for potential therapeutic interventions in the treatment of breast cancer metastasis. ..
  54. Zhu L, Liu R, Zhang W, Qian S, Wang J. MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells. Mol Med Rep. 2015;12:4652-4656 pubmed publisher
    ..As a result, miR?205 mimics inhibited USP7 protein levels while antisense miR?205 enhanced USP7 protein levels, thereby modulating the p53 signaling pathway ..
  55. Bucur O, Stancu A, Muraru M, Melet A, Petrescu S, Khosravi Far R. PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor. Discoveries (Craiova). 2014;2: pubmed
    ..Furthermore, PLK1 can directly phosphorylate FOXO3 in an in vitro kinase assay. These results present the discovery of PLK1 proto-oncogene as a binding partner and a negative regulator of FOXO3 tumor suppressor. ..
  56. Tan X, Liang R, Chuang S. hHR23A is required to control the basal turnover of Chk1. Cell Signal. 2015;27:2304-13 pubmed publisher
  57. Liu X, Yang X, Li Y, Zhao S, Li C, Ma P, et al. Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response. FEBS Lett. 2016;590:4213-4222 pubmed publisher
    The deubiquitinating enzyme, USP7/HAUSP (herpesvirus-associated ubiquitin-specific protease), is a key regulator of the tumor suppressor p53 and plays a major role in regulating genome stability...
  58. Nambu Nishida Y, Sakihama Y, Ishii J, Hasunuma T, Kondo A. Selection of yeast Saccharomyces cerevisiae promoters available for xylose cultivation and fermentation. J Biosci Bioeng. 2018;125:76-86 pubmed publisher
    ..were favorable for high expression, and PSED1, PHXT7, PPDC1, PTEF1, PTPI1, and PPGK1 were acceptable for medium-high expression in aerobic cultivation, ..
  59. Szypowska A, de Ruiter H, Meijer L, Smits L, Burgering B. Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. Antioxid Redox Signal. 2011;14:563-78 pubmed publisher
    ..Conversely, NLK-dependent inhibition of FOXO4 activity can provide a means to downregulate this defensive program, when oxidative stress reaches a level beyond which repair is no longer feasible and cells need to undergo apoptosis. ..