Gene Symbol: US4
Description: type 1 membrane protein; contains a signal peptide; involved in cell-to-cell spread
Alias: type 1 membrane protein, contains a signal peptide, involved in cell-to-cell spread, envelope glycoprotein G
Species: Human herpesvirus 2
Everett R, Fenwick M. Comparative DNA sequence analysis of the host shutoff genes of different strains of herpes simplex virus: type 2 strain HG52 encodes a truncated UL41 product. J Gen Virol. 1990;71 ( Pt 6):1387-90 pubmed publisher
..The results show that the UL41 genes of strains G and 17 are 86% homologous and that the lack of shutoff by HG52 is likely to be explained by a frameshift mutation within its UL41 coding sequence...
McGeoch D, Moss H, McNab D, Frame M. DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. J Gen Virol. 1987;68 ( Pt 1):19-38 pubmed
..major exception: the HSV-2 DNA contained an extra sequence of about 1460 base pairs, in the coding region of gene US4. By use of an antiserum raised against an oligopeptide representing amino acids near the C terminus of the ..
Bellner L, Thor n F, Nygren E, Liljeqvist J, Karlsson A, Eriksson K. A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions. J Immunol. 2005;174:2235-41 pubmed
..We propose that the proinflammatory gG-2p20 peptide identified could contribute to a reduced function and viability of NK cells during HSV-2 infection due to its ability to recruit and activate phagocytic cells...
McGeoch D, Cunningham C, McIntyre G, Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J Gen Virol. 1991;72 ( Pt 12):3057-75 pubmed
..Properties of the LAT sequences in both HSV-1 and HSV-2 were consistent with LATs being generated as an intron excised from a longer transcript. ..
Norberg P, Kasubi M, Haarr L, Bergstrom T, Liljeqvist J. Divergence and recombination of clinical herpes simplex virus type 2 isolates. J Virol. 2007;81:13158-67 pubmed
Adamiak B, Ekblad M, Bergstr m T, Ferro V, Trybala E. Herpes simplex virus type 2 glycoprotein G is targeted by the sulfated oligo- and polysaccharide inhibitors of virus attachment to cells. J Virol. 2007;81:13424-34 pubmed publisher
..This is a novel finding that suggests the involvement of HSV-2 gG in interactions with sulfated polysaccharides, including cell surface glycosaminoglycans...
Barnett B, Dolan A, Telford E, Davison A, McGeoch D. A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses. J Gen Virol. 1992;73 ( Pt 8):2167-71 pubmed publisher
..Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses...
Martinez Martin N, Viejo Borbolla A, Alcami A. Herpes simplex virus particles interact with chemokines and enhance cell migration. J Gen Virol. 2016;97:3007-3016 pubmed publisher
..Moreover, we found that HSV particles increase cell migration independently of chemokine binding to envelope gG. This work provides insights into HSV manipulation of the host immune system. ..