uPAR

Summary

Gene Symbol: uPAR
Description: plasminogen activator, urokinase receptor
Alias: CD87, U-PAR, UPAR, URKR, urokinase plasminogen activator surface receptor, monocyte activation antigen Mo3, u-plasminogen activator receptor form 2, urokinase-type plasminogen activator (uPA) receptor
Species: human
Products:     uPAR

Top Publications

  1. Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, et al. Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Res. 1999;59:5307-14 pubmed
    ..Recent studies indicate that the urokinase receptor (uPAR) is associated in large molecular complexes with other molecules, such as integrins...
  2. Alfano D, Ragno P, Stoppelli M, Ridley A. RhoB regulates uPAR signalling. J Cell Sci. 2012;125:2369-80 pubmed publisher
    Urokinase-type plasminogen activator (uPA) and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion...
  3. Raghu H, Gondi C, Dinh D, Gujrati M, Rao J. Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor. Mol Cancer. 2011;10:130 pubmed publisher
    uPA/uPAR is a multifunctional system that is over expressed in many cancers and plays a critical role in glioblastoma (GBM) invasion...
  4. Alfano M, Sidenius N, Panzeri B, Blasi F, Poli G. Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication. Proc Natl Acad Sci U S A. 2002;99:8862-7 pubmed
    Elevated levels of soluble urokinase-type plasminogen activator (uPA) receptor, CD87/u-PAR, predict survival in individuals infected with HIV-1...
  5. Poettler M, Unseld M, Mihaly Bison J, Uhrin P, Koban F, Binder B, et al. The urokinase receptor (CD87) represents a central mediator of growth factor-induced endothelial cell migration. Thromb Haemost. 2012;108:357-66 pubmed publisher
    ..Thus, VEGF165, VEGF-E, FGF-2, EGF as well as HGF induced a PI3k-dependent activation of pro-uPA when bound to uPAR, which led to an increase in cell surface fibrinolytic activity...
  6. Huai Q, Zhou A, Lin L, Mazar A, Parry G, Callahan J, et al. Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol. 2008;15:422-3 pubmed publisher
    The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown...
  7. Pluskota E, Soloviev D, Plow E. Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration. Blood. 2003;101:1582-90 pubmed
    ..CD11b/18, Mac-1) forms a physical complex with the urokinase-type plasminogen activator receptor (uPAR/CD87) on leukocytes...
  8. Li Y, Parry G, Chen L, Callahan J, Shaw D, Meehan E, et al. An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope. J Mol Biol. 2007;365:1117-29 pubmed
    Human urokinase-type plasminogen activator receptor (uPAR/CD87) is expressed at the invasive interface of the tumor-stromal microenvironment in many human cancers and interacts with a wide array of extracellular molecules...
  9. Liang O, Chavakis T, Kanse S, Preissner K. Ligand binding regions in the receptor for urokinase-type plasminogen activator. J Biol Chem. 2001;276:28946-53 pubmed
    The interaction between urokinase plasminogen activator (uPA) and its cellular receptor (uPAR) is a key event in cell surface-associated plasminogen activation, relevant for cell migration and invasion...

More Information

Publications143 found, 100 shown here

  1. Gardsvoll H, Kjaergaard M, Jacobsen B, Kriegbaum M, Huang M, Ploug M. Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor. J Biol Chem. 2011;286:43515-26 pubmed publisher
    ..interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) plays a regulatory role for both extravascular fibrinolysis and uPAR-mediated adhesion and migration on ..
  2. Margheri F, Chillà A, Laurenzana A, Serrati S, Mazzanti B, Saccardi R, et al. Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae. Blood. 2011;118:3743-55 pubmed publisher
    Endothelial urokinase-type plasminogen activator receptor (uPAR) is thought to provide a regulatory mechanism in angiogenesis...
  3. Almasi C, Brasso K, Iversen P, Pappot H, Høyer Hansen G, Danø K, et al. Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer. Prostate. 2011;71:899-907 pubmed publisher
    The purpose of this study was to investigate the prognostic value of different forms of the urokinase receptor, uPAR, in serum from prostate cancer (PC) patients. The uPAR forms were measured in samples from 131 metastatic PC patients...
  4. Artym V, Kindzelskii A, Chen W, Petty H. Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton. Carcinogenesis. 2002;23:1593-601 pubmed
    ..In this study we demonstrate that seprase and the urokinase plasminogen activator receptor (uPAR), co-localize in the plasma membrane of LOX malignant melanoma cells...
  5. Lester R, Jo M, Montel V, Takimoto S, Gonias S. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol. 2007;178:425-36 pubmed
    ..Hypoxia-induced EMT is accompanied by increased expression of the urokinase-type plasminogen activator receptor (uPAR) and activation of cell signaling factors downstream of uPAR, including Akt and Rac1...
  6. Soravia E, Grebe A, De Luca P, Helin K, Suh T, Degen J, et al. A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene. Blood. 1995;86:624-35 pubmed
    The urokinase-type plasminogen activator receptor (uPAR) focuses at the cell surface the activation of pro-uPA and, hence, the formation of plasmin, thus enhancing directional extracellular proteolysis...
  7. Yebra M, Goretzki L, Pfeifer M, Mueller B. Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction. Exp Cell Res. 1999;250:231-40 pubmed
    Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) participate in matrix degradation and cell migration by focusing proteolysis and functioning as a signaling ligand/receptor complex...
  8. Mazzieri R, D Alessio S, Kenmoe R, Ossowski L, Blasi F. An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration. Mol Biol Cell. 2006;17:367-78 pubmed
    Urokinase-type plasminogen activator (uPA) binding to uPAR induces migration, adhesion, and proliferation through multiple interactions with G proteins-coupled receptor FPRL1, integrins, or the epidermal growth factor (EGF) receptor (EGFR)..
  9. Smith H, Marra P, Marshall C. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol. 2008;182:777-90 pubmed publisher
    The urokinase-type plasminogen activator receptor (uPAR) drives tumor cell membrane protrusion and motility through activation of Rac; however, the pathway leading from uPAR to Rac activation has not been described...
  10. Coleman J, Benach J. The urokinase receptor can be induced by Borrelia burgdorferi through receptors of the innate immune system. Infect Immun. 2003;71:5556-64 pubmed
    Monocytic cells exposed to Borrelia burgdorferi, through unknown receptors, overexpress the urokinase receptor (uPAR), a key mediator of the plasminogen activation system...
  11. Salajegheh M, Rudnicki A, Smith T. Expression of urokinase-type plasminogen activator receptor (uPAR) in primary central nervous system neoplasms. Appl Immunohistochem Mol Morphol. 2005;13:184-9 pubmed
    The cellular receptor for urokinase-type plasminogen activator receptor (uPAR) is a member of the glycosylphosphatidylinositol (GPI) anchored protein family...
  12. Montuori N, Bifulco K, Carriero M, La Penna C, Visconte V, Alfano D, et al. The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor. Cell Mol Life Sci. 2011;68:2453-67 pubmed publisher
    The receptor (CXCR4) for the stromal-derived factor-1 (SDF1) and the urokinase-receptor (uPAR) are up-regulated in various tumors. We show that CXCR4-transfected cells migrate toward SDF1 on collagen (CG) and do not on vitronectin (VN)...
  13. Czekay R, Kuemmel T, Orlando R, Farquhar M. Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity. Mol Biol Cell. 2001;12:1467-79 pubmed
    ..internalization of urokinase:plasminogen activator inhibitor complexes (uPA:PAI-1) and the urokinase receptor (uPAR)...
  14. Benassi M, Ponticelli F, Azzoni E, Gamberi G, Pazzaglia L, Chiechi A, et al. Altered expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in high-risk soft tissue sarcomas. Histol Histopathol. 2007;22:1017-24 pubmed publisher
    ..fibrous histiocytomas, to evaluate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1). Immunohistochemistry of gene products was also performed...
  15. Alfano M, Mariani S, Elia C, Pardi R, Blasi F, Poli G. Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells. Blood. 2009;113:1699-709 pubmed publisher
    Urokinase-type plasminogen activator (uPA) signaling via its receptor uPAR inhibits late events in HIV-1 replication in acutely infected primary monocyte-derived macrophages (MDMs) and promonocytic U937 cells...
  16. de Bock C, Lin Z, Mekkawy A, Byrne J, Wang Y. Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion. Int J Oncol. 2010;36:1155-63 pubmed
    The urokinase-type plasminogen activator receptor (uPAR) has diverse biological functions including roles in proteolysis, cell adhesion and cellular signaling...
  17. Brunner P, Heier P, Mihaly Bison J, Priglinger U, Binder B, Prager G. Density enhanced phosphatase-1 down-regulates urokinase receptor surface expression in confluent endothelial cells. Blood. 2011;117:4154-61 pubmed publisher
    ..Therefore, expression of its cell surface receptor uPAR is thought to be an essential regulatory mechanism in angiogenesis...
  18. Høyer Hansen G, Ploug M, Behrendt N, Rønne E, Danø K. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. Eur J Biochem. 1997;243:21-6 pubmed
    The urokinase-type plasminogen activator (uPA) binds to a specific cell-surface receptor, uPAR. On several cell types uPAR is present both in the full-length form and a cleaved form, uPAR(2+3), which is devoid of binding activity...
  19. Nebuloni M, Cinque P, Sidenius N, Ferri A, Lauri E, Omodeo Zorini E, et al. Expression of the urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) in brain tissues of human immunodeficiency virus patients with opportunistic cerebral diseases. J Neurovirol. 2009;15:99-107 pubmed publisher
    The urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) play an important role in cell migration and extracellular proteolysis...
  20. Cinque P, Nebuloni M, Santovito M, Price R, Gisslen M, Hagberg L, et al. The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations. Ann Neurol. 2004;55:687-94 pubmed
    The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in extracellular matrix degradation and cell migration in the central nervous system (CNS)...
  21. Konno H, Baba M, Shoji T, Ohta M, Suzuki S, Nakamura S. Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. Clin Exp Metastasis. 2002;19:527-34 pubmed
    ..with CRC were assayed to determine the antigen levels of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2), as well as immunohistochemical expression of VEGF...
  22. Shetty S, Velusamy T, Idell S, Shetty P, Mazar A, Bhandary Y, et al. Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA. Mol Cell Biol. 2007;27:5607-18 pubmed
    We found that p53-deficient (p53(-/-)) lung carcinoma (H1299) cells express robust levels of cell surface uPAR and uPAR mRNA...
  23. Franco Palacios C, Lieske J, Wadei H, Rule A, Fervenza F, Voskoboev N, et al. Urine but not serum soluble urokinase receptor (suPAR) may identify cases of recurrent FSGS in kidney transplant candidates. Transplantation. 2013;96:394-9 pubmed publisher
    ..In advanced renal disease, elevated serum suPAR is not unique to FSGS cases. Urinary suPAR appears to be higher in cases of FSGS destined for recurrence and merits further evaluation. ..
  24. Kiyan J, Kiyan R, Haller H, Dumler I. Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta. EMBO J. 2005;24:1787-97 pubmed
    ..However, how intracellular signaling is linked to glycolipid-anchored uPA receptor (uPAR) is unknown...
  25. Shariat S, Roehrborn C, McConnell J, Park S, Alam N, Wheeler T, et al. Association of the circulating levels of the urokinase system of plasminogen activation with the presence of prostate cancer and invasion, progression, and metastasis. J Clin Oncol. 2007;25:349-55 pubmed
    To assess whether preoperative plasma levels of urokinase-type plasminogen activator (uPA) and its soluble receptor (uPAR) would predict cancer of the prostate (CaP) presence, stage, and prognosis...
  26. Bifulco K, Longanesi Cattani I, Franco P, Pavone V, Mugione P, Di Carluccio G, et al. Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. PLoS ONE. 2012;7:e44806 pubmed publisher
    The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration...
  27. Bernstein A, Twining S, Warejcka D, Tall E, Masur S. Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation. Mol Biol Cell. 2007;18:2716-27 pubmed
    ..focused on the role in fibroblasts of urokinase plasmingen activator/urokinase plasmingen activator receptor (uPA/uPAR), an extracellular protease system that promotes matrix remodeling, growth factor activation, and cell migration...
  28. Deng G, Curriden S, Wang S, Rosenberg S, Loskutoff D. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?. J Cell Biol. 1996;134:1563-71 pubmed
    Induction of the urokinase type plasminogen activator receptor (uPAR) promotes cell adhesion through its interaction with vitronectin (VN) in the extracellular matrix, and facilitates cell migration and invasion by localizing uPA to the ..
  29. Gopinath S, Malla R, Gondi C, Alapati K, Fassett D, Klopfenstein J, et al. Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. PLoS ONE. 2010;5:e11668 pubmed publisher
    Cathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas...
  30. Schiller H, Szekeres A, Binder B, Stockinger H, Leksa V. Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor. Mol Biol Cell. 2009;20:745-56 pubmed publisher
    ..M6P/IGF2R expression in urokinase-type plasminogen activator (uPA)/urokinase-type plasminogen activator receptor (uPAR) expressing human cancer and endothelial cells resulted in increased pericellular plasminogen activation, cell ..
  31. Sahores M, Prinetti A, Chiabrando G, Blasi F, Sonnino S. uPA binding increases UPAR localization to lipid rafts and modifies the receptor microdomain composition. Biochim Biophys Acta. 2008;1778:250-9 pubmed
    b>UPAR is a GPI anchored protein, which is found in both lipid rafts and in more fluid regions of the plasma membrane. We have studied the role of the ligand uPA on uPAR localization and on the composition of the lipid membrane microdomains...
  32. Dass C, Choong P. uPAR mediates anticancer activity of PEDF. Cancer Biol Ther. 2008;7:1262-70 pubmed
    ..In parallel, we have also shown using rodent cells, the beneficial effects of downregulation of uPAR against OS...
  33. Walker D, Lue L, Beach T. Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains. Brain Res. 2002;926:69-79 pubmed
    ..This receptor, also designated as CD87, is induced in response to a range of stimuli and is a marker of macrophage activation...
  34. Mazzieri R, Blasi F. The urokinase receptor and the regulation of cell proliferation. Thromb Haemost. 2005;93:641-6 pubmed
    ..acting on the extracellular matrix components, and by regulating the activity of important signal transducers, uPAR participates not only in the modulation of cell-cell and cell-extracellular matrix interactions, but also in the ..
  35. Dumler I, Weis A, Mayboroda O, Maasch C, Jerke U, Haller H, et al. The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem. 1998;273:315-21 pubmed
    The binding of urokinase plasminogen activator (uPA) to its specific receptor (uPAR) facilitates migration of vascular smooth muscle cells (VSMC)...
  36. Gardsvoll H, Jacobsen B, Kriegbaum M, Behrendt N, Engelholm L, Østergaard S, et al. Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction. J Biol Chem. 2011;286:33544-56 pubmed publisher
    The urokinase-type plasminogen activator receptor (uPAR) is a glycolipid-anchored membrane protein with an established role in focalizing uPA-mediated plasminogen activation on cell surfaces...
  37. Yoshizawa K, Nozaki S, Kitahara H, Kato K, Noguchi N, Kawashiri S, et al. Expression of urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma: Association with mode of invasion and clinicopathological factors. Oncol Rep. 2011;26:1555-60 pubmed publisher
    It is well documented that the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR), which has been implicated in cancer invasion and metastasis, is regulated by several inhibitors such as ..
  38. Degryse B, Resnati M, Czekay R, Loskutoff D, Blasi F. Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J Biol Chem. 2005;280:24792-803 pubmed
    We investigated the interaction between the urokinase receptor (uPAR) and the integrin alphavbeta3. Vitronectin (VN) induces cell migration by binding to alphavbeta3, but expression of the uPAR boosts its efficacy...
  39. McMahon B, Kwaan H. The plasminogen activator system and cancer. Pathophysiol Haemost Thromb. 2008;36:184-94 pubmed publisher
    ..Though both plasminogen activators, tPA and uPA, are expressed in tumor cells, uPA with its receptor (uPAR) is mostly involved in cellular functions, while tPA with its receptor annexin II on endothelial surface regulates ..
  40. Lindberg P, Larsson A, Nielsen B. Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer. 2006;118:2948-56 pubmed
    ..We have studied the expression of plasminogen activator inhibitor-1 (PAI-1) and urokinase receptor (uPAR) together with the gamma2-chain of laminin-5 (lam-gamma2) by immunohistochemistry in 20 cases with incipient oral ..
  41. Xu J, Li W, Bao X, Ding H, Chen J, Zhang W, et al. Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction. Clin Sci (Lond). 2010;119:353-9 pubmed publisher
    uPA (urokinase-plasminogen activator) and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of ..
  42. Kotzsch M, Bernt K, Friedrich K, Luther E, Albrecht S, Gatzweiler A, et al. Prognostic relevance of tumour cell-associated uPAR expression in invasive ductal breast carcinoma. Histopathology. 2010;57:461-71 pubmed publisher
    The urokinase-type plasminogen activator receptor (uPAR) is a key molecule for pericellular proteolysis in tumour cell invasion and metastasis...
  43. Hodjat M, Haller H, Dumler I, Kiyan Y. Urokinase receptor mediates doxorubicin-induced vascular smooth muscle cell senescence via proteasomal degradation of TRF2. J Vasc Res. 2013;50:109-23 pubmed publisher
    ..We observed that expression of urokinase receptor (uPAR) was upregulated in response to doxorubicin...
  44. Boonstra M, Verbeek F, Mazar A, Prevoo H, Kuppen P, Van De Velde C, et al. Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study. BMC Cancer. 2014;14:269 pubmed publisher
    The receptor for urokinase-type plasminogen activator (uPAR) is associated with cancer development and progression. Within the tumor microenvironment uPAR is expressed by malignant cells as well as tumor-associated stromal cells...
  45. Jo M, Thomas K, Marozkina N, Amin T, Silva C, Parsons S, et al. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem. 2005;280:17449-57 pubmed
    The urokinase-type plasminogen activator (uPA) receptor (uPAR) functions in concert with co-receptors, including integrins, FPR-like receptor-1/lipoxin A4 receptor, and the epidermal growth factor receptor (EGFR), to initiate cell ..
  46. Wei Y, Tang C, Kim Y, Robillard L, Zhang F, Kugler M, et al. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem. 2007;282:3929-39 pubmed
    ..Thus urokinase receptor binding to alpha5beta1 is required for maximal responses to fibronectin and tumor cell invasion, and this operates through an enhanced Src/Rac/ERK signaling pathway. ..
  47. Saldanha R, Molloy M, Bdeir K, Cines D, Song X, Uitto P, et al. Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy. J Proteome Res. 2007;6:1016-28 pubmed
    Urokinase plasminogen activator (uPA) and its high affinity receptor (uPAR) play crucial proteolytic and non-proteolytic roles in cancer metastasis...
  48. Sun L, Yan W, Wang Y, Sun G, Luo H, Zhang J, et al. MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res. 2011;1389:9-18 pubmed publisher
    ..We also found that miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10...
  49. Noh H, Hong S, Huang S. Role of urokinase receptor in tumor progression and development. Theranostics. 2013;3:487-95 pubmed publisher
    Elevated level of urokinase receptor (uPAR) is detected in various aggressive cancer types and is closely associated with poor prognosis of cancers...
  50. Sehestedt T, Lyngbæk S, Eugen Olsen J, Jeppesen J, Andersen O, Hansen T, et al. Soluble urokinase plasminogen activator receptor is associated with subclinical organ damage and cardiovascular events. Atherosclerosis. 2011;216:237-43 pubmed publisher
    ..Further studies must investigate whether suPAR plays an independent role in the pathogenesis of cardiovascular disease. ..
  51. Roldan A, Cubellis M, Masucci M, Behrendt N, Lund L, Danø K, et al. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J. 1990;9:467-74 pubmed
    The surface receptor for urokinase plasminogen activator (uPAR) has been recognized in recent years as a key molecule in regulating plasminogen mediated extracellular proteolysis...
  52. Pyke C, Eriksen J, Solberg H, Nielsen B, Kristensen P, Lund L, et al. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. FEBS Lett. 1993;326:69-74 pubmed
    ..of cDNA ends), we have isolated a cDNA variant for the receptor for human urokinase plasminogen activator (uPAR)...
  53. Stewart C, Nijmeh H, Brightling C, Sayers I. uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium. Thorax. 2012;67:477-87 pubmed publisher
    The asthma-associated gene urokinase plasminogen activator receptor (uPAR) may be involved in epithelial repair and airway remodelling. These processes are not adequately targeted by existing asthma therapies...
  54. Behrendt N, Rønne E, Ploug M, Petri T, Løber D, Nielsen L, et al. The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants. J Biol Chem. 1990;265:6453-60 pubmed
  55. Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A, et al. The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb Haemost. 2005;93:205-11 pubmed
    ..The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through ..
  56. Kjaergaard M, Hansen L, Jacobsen B, Gardsvoll H, Ploug M. Structure and ligand interactions of the urokinase receptor (uPAR). Front Biosci. 2008;13:5441-61 pubmed
    The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the ..
  57. Bacchiocchi R, Rubini C, Pierpaoli E, Borghetti G, Procacci P, Nocini P, et al. Prognostic value analysis of urokinase-type plasminogen activator receptor in oral squamous cell carcinoma: an immunohistochemical study. BMC Cancer. 2008;8:220 pubmed publisher
    ..involvement in other neoplasia, a crucial role is ascribed to the urokinase-type plasminogen activator receptor (uPAR), which plays a multiple role in extracellular proteolysis, cell migration and tissue remodelling not only as a ..
  58. Sato S, Kopitz C, Grismayer B, Beaufort N, Reuning U, Schmitt M, et al. Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo. Breast Cancer Res Treat. 2011;127:649-57 pubmed publisher
    b>uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice variants of this receptor have been reported...
  59. Raghu H, Lakka S, Gondi C, Mohanam S, Dinh D, Gujrati M, et al. Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines. PLoS ONE. 2010;5:e12458 pubmed publisher
    In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis in ..
  60. Vallabhaneni K, Tkachuk S, Kiyan Y, Shushakova N, Haller H, Dumler I, et al. Urokinase receptor mediates mobilization, migration, and differentiation of mesenchymal stem cells. Cardiovasc Res. 2011;90:113-21 pubmed publisher
    ..Our study was designed to elucidate a probable role for the multifunctional urokinase (uPA)/urokinase receptor (uPAR) system in MSC regulation...
  61. Kaneko T, Konno H, Baba M, Tanaka T, Nakamura S. Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer. Cancer Sci. 2003;94:43-9 pubmed
    ..were assayed immunohistochemically for expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), PA inhibitor-1 (PAI-1) and VEGF protein. The positive rates of uPA, uPAR, PAI-1, VEGF expression were 22.8%, 32...
  62. Sier C, Nicoletti I, Santovito M, Frandsen T, Aletti G, Ferrari A, et al. Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice. Thromb Haemost. 2004;91:403-11 pubmed
    The urokinase-type plasminogen activator receptor (uPAR) is involved in cell migration and tissue remodelling, as a receptor for pro-uPA, as a cell adhesion component, and in a soluble form as a chemoattractant...
  63. Subramanian R, Gondi C, Lakka S, Jutla A, Rao J. siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells. Int J Oncol. 2006;28:831-9 pubmed
    A wide variety of tumor cells exhibit overexpression of urokinase plasminogen activator (uPA) and its receptor (uPAR). In breast cancer, expression of uPA and uPAR is essential for tumor cell invasion and metastasis...
  64. Cozzi P, Wang J, Delprado W, Madigan M, Fairy S, Russell P, et al. Evaluation of urokinase plasminogen activator and its receptor in different grades of human prostate cancer. Hum Pathol. 2006;37:1442-51 pubmed
    Increased expression of urokinase plasminogen activator (uPA) and its receptor (uPAR) has been reported in various malignancies including prostate cancer (CaP)...
  65. Gondi C, Dinh D, Gujrati M, Rao J. Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas. Int J Oncol. 2008;33:783-90 pubmed
    ..of simultaneous RNA interference (RNAi)-mediated downregulation of urokinase-type plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9) in inhibiting tumor invasion in vitro and in vivo...
  66. Wei C, El Hindi S, Li J, Fornoni A, Goes N, Sageshima J, et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med. 2011;17:952-60 pubmed publisher
    ..plasmapheresis, or by interfering with the suPAR-?(3) integrin interaction through antibodies and small molecules targeting either uPAR or ?(3) integrin. Our study identifies serum suPAR as a circulating factor that may cause FSGS.
  67. Veeravalli K, Rao J. MMP-9 and uPAR regulated glioma cell migration. Cell Adh Migr. 2012;6:509-12 pubmed publisher
    Integrin-dependent and -independent MMP-9 and uPAR signaling plays a key role in glioma cell migration and invasion...
  68. Beaufort N, Debela M, Creutzburg S, Kellermann J, Bode W, Schmitt M, et al. Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR). Biol Chem. 2006;387:217-22 pubmed
    ..the serine protease urokinase-type plasminogen activator (uPA) and its three-domain (D1D2D3) receptor uPAR (CD87), which focuses plasminogen activation to the cell surface...
  69. Caiolfa V, Zamai M, Malengo G, Andolfo A, Madsen C, Sutin J, et al. Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol. 2007;179:1067-82 pubmed
    ..exchange and membrane dynamics and confinement, we studied urokinase plasminogen activator (uPA) receptor (uPAR), a GPI receptor involved in the regulation of cell adhesion, migration, and proliferation...
  70. Tang C, Hill M, Brumwell A, Chapman H, Wei Y. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. J Cell Sci. 2008;121:3747-56 pubmed publisher
    The urokinase receptor (uPAR) is upregulated upon tumor cell invasion and correlates with poor lung cancer survival...
  71. Minoo P, Baker K, Baumhoer D, Terracciano L, Lugli A, Zlobec I. Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer. Hum Pathol. 2010;41:70-8 pubmed publisher
    ..study was to determine the prognostic significance of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in colorectal cancer stratified by mismatch repair status and to determine their contribution to the aggressive ..
  72. Illemann M, Bird N, Majeed A, Laerum O, Lund L, Danø K, et al. Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int J Cancer. 2009;124:1860-70 pubmed publisher
    ..Plasmin(ogen) is activated on cell surfaces by urokinase-type PA (uPA), and is regulated by uPAR and plasminogen activator inhibitor-1 (PAI-1)...
  73. Andolfo A, English W, Resnati M, Murphy G, Blasi F, Sidenius N. Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor. Thromb Haemost. 2002;88:298-306 pubmed
    ..activator receptor (uPA(R)) prevents the binding of uPA and vitronectin while generating biologically active uPAR fragments...
  74. Beaufort N, Leduc D, Rousselle J, Magdolen V, Luther T, Namane A, et al. Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J Immunol. 2004;172:540-9 pubmed
    The urokinase receptor (CD87) participates to the pericellular proteolytic potential of migrating cells and to the recruitment of leukocytes during inflammation...
  75. Stewart C, Hall I, Parker S, Moffat M, Wardlaw A, Connolly M, et al. PLAUR polymorphisms and lung function in UK smokers. BMC Med Genet. 2009;10:112 pubmed publisher
    ..PLAUR is a key serine protease receptor involved in the generation of plasmin and has been implicated in airway remodelling. ..
  76. Møller L, Ploug M, Blasi F. Structural requirements for glycosyl-phosphatidylinositol-anchor attachment in the cellular receptor for urokinase plasminogen activator. Eur J Biochem. 1992;208:493-500 pubmed
  77. Simon D, Wei Y, Zhang L, Rao N, Xu H, Chen Z, et al. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. J Biol Chem. 2000;275:10228-34 pubmed
    ..One such protein, the glycolipid-anchored urokinase receptor (uPAR), associates with and modifies the function of the beta(2)-integrin Mac-1 (CD11b/CD18)...
  78. Kjøller L. The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility. Biol Chem. 2002;383:5-19 pubmed
    ..The GPI-anchored urokinase plasminogen activator receptor (uPAR) has an important role in the regulation of cell motility in many cell types...
  79. Montuori N, Carriero M, Salzano S, Rossi G, Ragno P. The cleavage of the urokinase receptor regulates its multiple functions. J Biol Chem. 2002;277:46932-9 pubmed
    The urokinase-type plasminogen activator (uPA) is able to cleave its cell surface receptor (uPAR) anchored to the cell membrane through a glycophosphatidylinositol tail...
  80. Sitrin R, Johnson D, Pan P, Harsh D, Huang J, Petty H, et al. Lipid raft compartmentalization of urokinase receptor signaling in human neutrophils. Am J Respir Cell Mol Biol. 2004;30:233-41 pubmed
    Urokinase plasminogen activator (uPA) receptors (uPAR) can be engaged for activation signaling either by aggregation or by binding exogenous uPA...
  81. Sturge J, Wienke D, East L, Jones G, Isacke C. GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol. 2003;162:789-94 pubmed
    Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell guidance and chemotaxis during normal and pathological events...
  82. Aref S, el Sherbiny M, Mabed M, Menessy A, El Refaei M. Urokinase plasminogen activator receptor and soluble matrix metalloproteinase-9 in acute myeloid leukemia patients: a possible relation to disease invasion. Hematology. 2003;8:385-91 pubmed
    ..The receptor for urokinase plasminogen activator (uPAR) serves to localize and intensify the action of UPA and is expressed on the surface of malignant cells...
  83. Bass R, Werner F, Odintsova E, Sugiura T, Berditchevski F, Ellis V. Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. J Biol Chem. 2005;280:14811-8 pubmed
    ..interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored cellular receptor (uPAR) promotes plasminogen activation and the efficient generation of pericellular proteolytic activity...
  84. Lakka S, Gondi C, Dinh D, Olivero W, Gujrati M, Rao V, et al. Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas. J Biol Chem. 2005;280:21882-92 pubmed
    ..the effectiveness of adenovirus-mediated expression of antisense urokinase-type plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9) in inhibiting tumor invasion in vitro and ex vivo...
  85. Ghosh S, Johnson J, Sen R, Mukhopadhyay S, Liu Y, Zhang F, et al. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem. 2006;281:13021-9 pubmed
    ..of integrin alpha3beta1 and enhanced production of urinary-type plasminogen activator (uPA) and its receptor (uPAR) relative to normal oral mucosa...
  86. Li C, Cao S, Liu Z, Ye X, Chen L, Meng S. RNAi-mediated downregulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells. Int J Cancer. 2010;127:1507-16 pubmed publisher
    Overexpression of urokinase plasminogen activator receptor (uPAR) or HER2 (erbB-2) in breast cancer is associated with a poor prognosis...
  87. Raghu H, Sodadasu P, Malla R, Gondi C, Estes N, Rao J. Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells. BMC Cancer. 2010;10:647 pubmed publisher
    b>uPAR and MMP-9, which play critical roles in tumor cell invasion, migration and angiogenesis, have been shown to be associated with lipid rafts...
  88. Hellriegel C, Caiolfa V, Corti V, Sidenius N, Zamai M. Number and brightness image analysis reveals ATF-induced dimerization kinetics of uPAR in the cell membrane. FASEB J. 2011;25:2883-97 pubmed publisher
    We studied the molecular forms of the GPI-anchored urokinase plasminogen activator receptor (uPAR-mEGFP) in the human embryo kidney (HEK293) cell membrane and demonstrated that the binding of the amino-terminal fragment (ATF) of urokinase ..
  89. Kruger R, Schutte R, Huisman H, Hindersson P, Olsen M, Eugen Olsen J, et al. NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. PLoS ONE. 2013;8:e58506 pubmed publisher
  90. Cubellis M, Andreasen P, Ragno P, Mayer M, Danø K, Blasi F. Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor. Proc Natl Acad Sci U S A. 1989;86:4828-32 pubmed
    ..The possibility that in adherent cells a different localization of PAI-1 and uPA leads to protection of uPA from PAI-1 is to be considered. ..
  91. Nykjaer A, Christensen E, Vorum H, Hager H, Petersen C, Røigaard H, et al. Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction. J Cell Biol. 1998;141:815-28 pubmed
    The urokinase-type plasminogen activator receptor (uPAR) plays an important role on the cell surface in mediating extracellular degradative processes and formation of active TGF-beta, and in nonproteolytic events such as cell adhesion, ..
  92. Selleri C, Montuori N, Ricci P, Visconte V, Carriero M, Sidenius N, et al. Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood. 2005;105:2198-205 pubmed
    We investigated the involvement of the urokinase-type plasminogen-activator receptor (uPAR) in granulocyte-colony-stimulating factor (G-CSF)-induced mobilization of CD34+ hematopoietic stem cells (HSCs) from 16 healthy donors...