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Genomes and Genes | ULBP3SummaryGene Symbol: ULBP3 Description: UL16 binding protein 3 Alias: RAET1N, ALCAN-gamma, N2DL-3, NKG2D ligand 3, NKG2DL3, UL16-binding protein 3, retinoic acid early transcript 1N Species: human Top Publications
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Publications
UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cellsClaire L Sutherland
Department of Molecular Biology, Immunex, Seattle, WA 98101, USA
J Immunol 168:671-9. 2002..While all three ULBPs activate the same signaling pathways, ULBP3 was found to bind weakly and to induce the weakest signal...- Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysisCristina Cerboni
Department of Experimental Medicine, Istituto Pasteur Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy
Blood 110:606-15. 2007..on both CD4(+) and CD8(+) T cells in 90% of the donors tested, while UL16-binding protein-1 (ULBP)1, ULBP2, and ULBP3 were induced at later times in 55%-75% of the donors... 
Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligandsSteffen Muller
Interfaculty Institute for Biochemistry, University of Tuebingen, Tuebingen, Germany
PLoS Pathog 6:e1000723. 2010..An arginine residue at this position however, as found for example in MICA or ULBP3, would cause steric clashes with UL16 residues...- The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cellsLola Fernández-Messina
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK
J Cell Sci 124:321-7. 2011..Here, we demonstrate that ULBP2, but not ULBP1 or ULBP3, can reach the cell surface without the GPI modification... - HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage responseJeffrey Ward
Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, New York, United States of America
PLoS Pathog 5:e1000613. 2009..When T-cell blasts are infected with a vpr-deficient HIV-1, NK cells are impaired in killing the infected cells. Thus, HIV-1 Vpr actively triggers the expression of the ligands to the NK cell activation receptor... - ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptorD Cosman
Department of Molecular Biology, Immunex Corporation, 51 University Street, Seattle, WA 98101
Immunity 14:123-33. 2001..Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system... - Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein familyA Steinle
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
Immunogenetics 53:279-87. 2001..Varying affinities of MICA alleles for NKG2D may affect thresholds of NK-cell triggering and T-cell modulation... - Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligandsLola Fernández-Messina
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
J Biol Chem 285:8543-51. 2010..and cellular approaches in both transfectant systems and tumor cell lines, this paper shows that ULBP1, ULBP2, and ULBP3 are released from cells with different kinetics and by distinct mechanisms... 
ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patientsRoger W McGilvray
Academic Division of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottingham, United Kingdom
Int J Cancer 127:1412-20. 2010..Patients whose tumors had high expression of RAET1E (p = 0.037), ULBP1 (p = 0.036) and ULBP3 (p = 0...- Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern ThaisAmornrat V Romphruk
Blood Transfusion Center, Faculty of Medicine, Khon Kaen University KKU, Khon Kaen 40002, Thailand
Immunogenetics 61:611-7. 2009..These are ULBP1 or RAET1I, ULBP2 or RAET1H, ULBP3 or RAET1N, and RAET1L, which are glycosylinositol phospholipid (GPI)-linked glycoproteins and ULBP4 or RAET1E and ULBP5 or .. - [Matrine enhances the cytotoxic sensitivity of ABCG2high nasopharyngeal carcinoma cells to natural killer cells by inducing high expression of NKG2D receptor ligands]Yu Xian Huang
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Nan Fang Yi Ke Da Xue Xue Bao 29:1329-32. 2009.... - Proteasome regulation of ULBP1 transcriptionJames E Butler
Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA
J Immunol 182:6600-9. 2009..HNSCC cells typically expressed MHC class I chain-related gene A (MICA), MICB, UL16-binding protein (ULBP)2, and ULBP3, but they were uniformly negative for cell surface ULBP1 and ULBP4... - Reliability of tumor markers, chemokines, and metastasis-related molecules in serumFaina Linkov
University of Pittsburgh Cancer Institute, Division of Cancer Prevention and Population Science, 5150 Centre Ave, Room 466, Pittsburgh, PA 15224, USA
Eur Cytokine Netw 20:21-6. 2009..These included cancer antigens: CA 19-9, CA 72-4, MICA, S100, TTR, ULBP1, ULBP2, ULBP3; proteases: MMP 2, 3, 7, 12, 13; chemokines: MCP-3, MIF, MIG; adipokines: leptin and resistin; apoptotic factors: .. - Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populationsAyman Antoun
School of Cancer Sciences, Birmingham University, Birmingham, United Kingdom
Hum Immunol 71:610-20. 2010..Interestingly, variation was focused within the RAET1E (ULBP4), RAET1L, and ULBP3 genes, whereas the ULBP1, ULBP2 and RAET1G (ULBP5) genes were highly conserved... - Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirusNeil J Bennett
Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
J Immunol 185:1093-102. 2010..In this article, we show that the HCMV gene product UL142 can prevent cell surface expression of ULBP3 during infection... - Methylation-specific ligation detection reaction (msLDR): a new approach for multiplex evaluation of methylation patternsFelix Bormann
Institute of Pathology, University Medicine Charité, Charitéplatz1, 10117 Berlin, Germany
Mol Genet Genomics 286:279-91. 2011..Parallel analysis of HLA-A, HLA-B, STAT1, B2M, LMP2, LMP7, PA28α, TAP1, TAP2, TAPBP, ULBP2 and ULBP3 by msLDR in eight colorectal cancer cell lines showed preferential methylation at the HLA-B, ULBP2 and ULBB3 loci, .. - Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and functionHeba Abdelrazik
Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Universita degli Studi di Genova, Genova, Italy
Eur J Immunol 41:3281-90. 2011..expression of some relevant MSC surface molecules, namely the DNAM-1 ligands PVR and Nectin-2, the NKG2D ligand ULBP3, the adhesion molecules CD49d and αvβ3 and the fibroblast-associated protein... - Treatment of alopecia areata: "What is new on the horizon?"Maria K Hordinsky
Department of Dermatology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Dermatol Ther 24:364-8. 2011..Special attention is being given to the UL 16-binding protein (ULBP3) gene cluster on chromosome 6q25, as these genes make the NKG2D-activating ligand or signal that can trigger the .. - MicroRNA based immunoevasion mechanism of human polyomavirusesYoav Bauman
The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
RNA Biol 8:591-4. 2011..This identical miRNA targets the stress-induced protein ULBP3, which is recognized by the killer receptor NKG2D and thus, through the usage of a miRNA, JCV and BKV avoid the .. - An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune eliminationYoav Bauman
The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
Cell Host Microbe 9:93-102. 2011..Here we show that a viral miRNA identical in sequence between JCV and BKV targets the stress-induced ligand ULBP3, which is a protein recognized by the killer receptor NKG2D... - Induction of NKG2D ligands and increased sensitivity of tumor cells to NK cell-mediated cytotoxicity by hematoporphyrin-based photodynamic therapyMin Ju Park
Department of Biochemistry, Pusan National University School of Medicine, Yangsan 626 870, South Korea
Immunol Invest 40:367-82. 2011..surface expression of ULBP1 and ULBP2 genes in SNU-1 human gastric tumor cell line and MICA/B, ULBP1, ULBP2 and ULBP3 genes in SW-900 human lung cancer cell line... - Genome-wide association study in alopecia areata implicates both innate and adaptive immunityLynn Petukhova
Department of Dermatology, Columbia University, New York, New York 10032, USA
Nature 466:113-7. 2010..By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly .. - [Expression of NKG2D ligands on dendritic cells at different development stages and its effect on cytotoxicity of NK cells]San fang Tu
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:341-3, 347. 2008..To investigate the expression of NKG2D ligands on dendritic cells(DC) at different development stages and its effect on cytotoxicity of natural killer(NK) cells... - RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicityWei Cao
Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005 China
J Biol Chem 282:18922-8. 2007..ULBP1, ULBP2, ULBP3, and RAET1L link to membrane through glycosylphosphatidylinositol, whereas RAET1E and RAET1G contain transmembrane .. - Human natural killer lymphocytes through the engagement of natural cytotoxicity receptors and NKG2D can trigger self-aggressionAlessandro Poggi
Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
Autoimmun Rev 6:295-9. 2007..Both types of SC bear the MHC-related molecule MIC-A and the UL16 binding protein ULBP3, which engagement with NKG2D, expressed by NK, is responsible for the delivery of lethal hit... - A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3Mirjana Radosavljevic
INSERM CReS, Centre de Recherche d Immunologie et d Hématologie, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
Genomics 79:114-23. 2002..The involvement of orthologous mouse RAET1A-D/H60 in natural killer and T-cell activation through NKG2D engagement augurs a similar function for the human RAET1 proteins... - Generating isomorphous heavy-atom derivatives by a quick-soak method. Part II: phasing of new structuresPeter D Sun
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
Acta Crystallogr D Biol Crystallogr 58:1099-103. 2002..type II transforming growth factor beta receptor (TBRII) and a natural killer cell receptor-ligand complex, NKG2D-ULBP3. In the case of TBRII, a crystal derivatized for only 10 min in saturated HgCl(2) provided adequate phasing for .. - Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoproteinStefan A Welte
Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, Tubingen, Germany
Eur J Immunol 33:194-203. 2003..However, solely MICA and ULBP3 reach the cellular surface to engage NKG2D, whereas MICB, ULBP1 and ULBP2 are selectively retained in the .. - NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancerA Cerwenka
German Cancer Center DKFZ 0080 IM Neuenheimerfeld D 69120 Heidelberg 280 Germany
Tissue Antigens 61:335-43. 2003..Moreover, we describe how viruses and cancer have developed strategies to evade this recognition pathway... - Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 proteinAlexander Rölle
Microbiology and Tumor Biology Center and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
J Immunol 171:902-8. 2003..However, while at a lower viral dose ULBP1 and 2 surface expression was completely inhibited compared to ULBP3, at a higher viral dose cell surface expression of ULBP1 and ULBP2 was delayed... - Structure and function of natural-killer-cell receptorsPeter D Sun
Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
Immunol Res 27:539-48. 2003..families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their .. - Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2DKonstantina Eleme
Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
J Exp Med 199:1005-10. 2004..Western blotting revealed that glycosylphosphatidylinositol (GPI)-anchored ULBP3 but not transmembrane MICA, MHC class I protein, or transferrin receptor, accumulated in detergent-resistant .. - Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemiasPegah Nowbakht
Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
Blood 105:3615-22. 2005..Analysis of UL16-binding protein-1 (ULBP1), ULBP2, and ULBP3 ligands for NKG2D and of potential ligands for NKp30, NKp44, and NKp46 in healthy hematopoietic cells demonstrated .. - Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacteriumRamakrishna Vankayalapati
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708, USA
J Immunol 175:4611-7. 2005..monocytes up-regulated expression of the NKG2D ligand, UL-16 binding protein (ULBP)1, but not expression of ULBP2, ULBP3, or MHC class I-related chain A or chain B... - ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15Claire L Sutherland
Department of Oncology, Amgen Inc, Seattle, WA, 98119, USA
Blood 108:1313-9. 2006..Although binding of ULBP3 to murine NKG2D could not be demonstrated in vitro, ULBP3 can also stimulate antitumor responses, suggesting that .. - TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cellsGünter Eisele
Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
Brain 129:2416-25. 2006..during malignant progression and selectively downregulates MICA, ULBP2 and ULBP4 expression, while MICB, ULBP1 and ULBP3 are unaffected... - Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteinsSilvia Catellani
Laboratory of Hematology, University of Genoa, Genoa, Italy
Blood 109:2078-85. 2007..with increased circulating Vdelta1 T lymphocytes, B cells expressing the UL-16-binding proteins (ULBPs) ULBP2 or ULBP3 or both were found in peripheral blood, bone marrow, or lymph nodes... - Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapsesShlomo Nedvetzki
Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
Blood 109:3776-85. 2007..ligands on macrophages: high doses of LPS induced transcription and surface expression of ULBP1, ULBP2, and ULBP3 and surface expression of constitutively transcribed MICA... - DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cellsMattias Carlsten
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
Cancer Res 67:1317-25. 2007..DNAM-1) ligand PVR and sparse/heterogeneous expression of the NKG2D ligands MICA/MICB and ULBP1, ULBP2, and ULBP3. In line with the NK receptor ligand expression profiles, antibody-mediated blockade of activating receptor .. - NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infectionMonia Draghi
Department of Structural Biology, 299 Campus Drive West, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 178:2688-98. 2007..Poly(I:C)-treated DCs did not express the UL16-binding protein 3 ligand for NKG2D, and in the absence of the influenza hemagglutinin there was no involvement of NKp46... - Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3S Radaev
Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
Immunity 15:1039-49. 2001..In the NKG2D/ULBP3 complex, the structure of ULBP3 resembles the alpha1 and alpha2 domains of classical MHC molecules without a bound ..
Research Grants
- The role of NK cells in human M. Tuberculosis infectionRamakrishna Vankayalapati; Fiscal Year: 2009..These findings will facilitate development of immunomodulatory strategies to boost the immune response to M. tuberculosis, including multidrug-resistant tuberculosis. ..