ULBP3

Summary

Gene Symbol: ULBP3
Description: UL16 binding protein 3
Alias: RAET1N, ALCAN-gamma, N2DL-3, NKG2D ligand 3, NKG2DL3, UL16-binding protein 3, retinoic acid early transcript 1N
Species: human

Top Publications

  1. ncbi UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
    Claire L Sutherland
    Department of Molecular Biology, Immunex, Seattle, WA 98101, USA
    J Immunol 168:671-9. 2002
  2. ncbi Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
    Cristina Cerboni
    Department of Experimental Medicine, Istituto Pasteur Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy
    Blood 110:606-15. 2007
  3. pmc Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands
    Steffen Muller
    Interfaculty Institute for Biochemistry, University of Tuebingen, Tuebingen, Germany
    PLoS Pathog 6:e1000723. 2010
  4. pmc The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells
    Lola Fernández-Messina
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK
    J Cell Sci 124:321-7. 2011
  5. pmc HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response
    Jeffrey Ward
    Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, New York, United States of America
    PLoS Pathog 5:e1000613. 2009
  6. ncbi ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    D Cosman
    Department of Molecular Biology, Immunex Corporation, 51 University Street, Seattle, WA 98101
    Immunity 14:123-33. 2001
  7. ncbi Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
    A Steinle
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Immunogenetics 53:279-87. 2001
  8. pmc DNA methylation in nasal epithelial cells from smokers: identification of ULBP3-related effects
    Julia E Rager
    Center for Environmental Medicine, Asthma, and Lung Biology, Univ of North Carolina at Chapel Hill, 104 Mason Farm Rd CB 7310, Chapel Hill, NC 27599 7310
    Am J Physiol Lung Cell Mol Physiol 305:L432-8. 2013
  9. doi [Effects of Matrine on the Expression of NKG2D Ligands in Leukemia Cells]
    Ling Di Ma
    Lab Center, Changzhou No 2 People s Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China E mail
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:1429-34. 2013
  10. pmc Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma
    Xiaosong Wu
    Department of Hematology, Shanghai Tenth People s Hospital, Tongji University School of Medicine, Shanghai, China
    Neoplasia 14:1178-89. 2012

Research Grants

Scientific Experts

  • Monia Draghi
  • Peter D Sun
  • I Jaspers
  • Maria Raffaella Zocchi
  • Felix Bormann
  • San fang Tu
  • A Antoun
  • Alessandro Poggi
  • Maria Hordinsky
  • Günter Eisele
  • Claire L Sutherland
  • Ramakrishna Vankayalapati
  • A Cerwenka
  • D Cosman
  • Alexander Rölle
  • Terry L Noah
  • Yoav Bauman
  • Lola Fernández-Messina
  • John Trowsdale
  • Omodele Ashiru
  • Ling Di Ma
  • Luisa E Brighton
  • J Luis Espinoza
  • Loretta Müller
  • Julia E Rager
  • Mei Huang
  • Dagny Jagielska
  • Chaoming Mao
  • Xiaosong Wu
  • Ofer Mandelboim
  • Min Ju Park
  • Heba Abdelrazik
  • Jason M Norman
  • Hugh T Reyburn
  • Sonia Agüera-González
  • Mar Vales-Gomez
  • Steffen Muller
  • Roger W McGilvray
  • Neil J Bennett
  • Lynn Petukhova
  • Yu Xian Huang
  • James E Butler
  • Amornrat V Romphruk
  • Faina Linkov
  • Jeffrey Ward
  • Robert A Eagle
  • Cristina Cerboni
  • Silvia Catellani
  • Mattias Carlsten
  • Wei Cao
  • Shlomo Nedvetzki
  • Alexander Steinle
  • N Jan Chalupny
  • Daniel M Davis
  • Pegah Nowbakht
  • Konstantina Eleme
  • Stefan A Welte
  • Sergei Radaev
  • Mirjana Radosavljevic
  • Shinji Nakao
  • Rebecca C Fry
  • Si Xuan Qian
  • Loretta L Müller
  • Rui Sun
  • Min Zhou
  • Akiyoshi Takami
  • Xu Zhang Lu
  • Johnny L Carson
  • Jian Yong Li
  • Ly Q Trung
  • Lisa Smeester
  • Zhi Chao Zhu
  • Haiming Wei
  • Rebecca N Bauer
  • Zhigang Tian
  • Li jia Jiang
  • Danxia Bao
  • Gerhard Lutz
  • Sandra Hanneken
  • Deyu Chen
  • Sibylle Eigelshoven
  • Markus M Nothen
  • Silke Redler
  • Jumei Shi
  • Melanie Refke
  • Huaxi Xu
  • Shengjun Wang
  • S Radaev
  • Hans Wolff
  • Wei Qin

Detail Information

Publications54

  1. ncbi UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
    Claire L Sutherland
    Department of Molecular Biology, Immunex, Seattle, WA 98101, USA
    J Immunol 168:671-9. 2002
    ..While all three ULBPs activate the same signaling pathways, ULBP3 was found to bind weakly and to induce the weakest signal...
  2. ncbi Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
    Cristina Cerboni
    Department of Experimental Medicine, Istituto Pasteur Fondazione Cenci Bolognetti, University La Sapienza, Rome, Italy
    Blood 110:606-15. 2007
    ..on both CD4(+) and CD8(+) T cells in 90% of the donors tested, while UL16-binding protein-1 (ULBP)1, ULBP2, and ULBP3 were induced at later times in 55%-75% of the donors...
  3. pmc Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands
    Steffen Muller
    Interfaculty Institute for Biochemistry, University of Tuebingen, Tuebingen, Germany
    PLoS Pathog 6:e1000723. 2010
    ..An arginine residue at this position however, as found for example in MICA or ULBP3, would cause steric clashes with UL16 residues...
  4. pmc The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells
    Lola Fernández-Messina
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK
    J Cell Sci 124:321-7. 2011
    ..Here, we demonstrate that ULBP2, but not ULBP1 or ULBP3, can reach the cell surface without the GPI modification...
  5. pmc HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response
    Jeffrey Ward
    Department of Microbiology and Immunology, State University of New York, Upstate Medical University, Syracuse, New York, United States of America
    PLoS Pathog 5:e1000613. 2009
    ..When T-cell blasts are infected with a vpr-deficient HIV-1, NK cells are impaired in killing the infected cells. Thus, HIV-1 Vpr actively triggers the expression of the ligands to the NK cell activation receptor...
  6. ncbi ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    D Cosman
    Department of Molecular Biology, Immunex Corporation, 51 University Street, Seattle, WA 98101
    Immunity 14:123-33. 2001
    ..Masking of NK cell recognition of ULBP or MIC antigens by UL16 provides a potential mechanism by which human cytomegalovirus-infected cells might evade attack by the immune system...
  7. ncbi Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family
    A Steinle
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Immunogenetics 53:279-87. 2001
    ..Varying affinities of MICA alleles for NKG2D may affect thresholds of NK-cell triggering and T-cell modulation...
  8. pmc DNA methylation in nasal epithelial cells from smokers: identification of ULBP3-related effects
    Julia E Rager
    Center for Environmental Medicine, Asthma, and Lung Biology, Univ of North Carolina at Chapel Hill, 104 Mason Farm Rd CB 7310, Chapel Hill, NC 27599 7310
    Am J Physiol Lung Cell Mol Physiol 305:L432-8. 2013
    ..genes, of which five were differentially methylated in NEC from smokers (CCL2, FDPS, GSK3B, SOCS3, and ULBP3)...
  9. doi [Effects of Matrine on the Expression of NKG2D Ligands in Leukemia Cells]
    Ling Di Ma
    Lab Center, Changzhou No 2 People s Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China E mail
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:1429-34. 2013
    ..Much higher expressions of ULBP2 and ULBP3 were found in K562 cells, compared to the other cell lines, which partly contributes to the higher sensitivity of ..
  10. pmc Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma
    Xiaosong Wu
    Department of Hematology, Shanghai Tenth People s Hospital, Tongji University School of Medicine, Shanghai, China
    Neoplasia 14:1178-89. 2012
    ..chain (MIC) A/B and UL16-binding protein (ULBP) 2 without any significant effect on the expression of ULBP1, ULBP3, and ULBP4 or induction of other natural killer (NK) cell ligands, such as NKp30-L, NKp44-L, and NKp46-L in ..
  11. doi A monoclonal antibody against human UL16-binding protein 3
    Chaoming Mao
    Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
    Hybridoma (Larchmt) 31:203-8. 2012
    ..In this study, the gene encoding human ULBP3 was cloned into prokaryotic expression vector pQE30, resulting in a recombinant plasmid pQE30-ULBP3...
  12. doi High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas
    Maria Raffaella Zocchi
    Division of Immunology, Transplants and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    Blood 119:1479-89. 2012
    ..were detected both in LN mesenchymal stromal cells (MSCs) and in Reed-Sternberg (RS) cells; in addition, MIC-A and ULBP3 were present in culture supernatants of LN MSCs or RS cells...
  13. doi Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance
    Dagny Jagielska
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Invest Dermatol 132:2192-7. 2012
    ..Of the five loci with previously reported genome-wide significance, association was confirmed for all of these: ULBP3/ULBP6, PRDX5, IL-2/IL-21, STX17, and IKZF4/ERBB3 (P-value <0.05)...
  14. doi Simultaneous knockdown of multiple ligands of innate receptor NKG2D prevents natural killer cell-mediated fulminant hepatitis in mice
    Mei Huang
    Department of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China
    Hepatology 57:277-88. 2013
    ..Noticeably, simultaneous knockdown of multiple human NKG2D ligands (MICA/B, ULBP2, and ULBP3) also significantly attenuated NK cell cytolysis against human NKG2D ligand-positive hepatocyte L-02 cells, ..
  15. pmc Ozone exposed epithelial cells modify cocultured natural killer cells
    Loretta Müller
    Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 304:L332-41. 2013
    ..media of O3-exposed NECs alone did not reduce intracellular IFN-γ, O3 enhanced the expression of NK cell ligands ULBP3 and MICA/B on NECs...
  16. doi Ataxia-telangiectasia mutated kinase-mediated upregulation of NKG2D ligands on leukemia cells by resveratrol results in enhanced natural killer cell susceptibility
    J Luis Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    Cancer Sci 104:657-62. 2013
    ..the NKG2D-Ls MHC class I chain-related proteins MICA and MICB, and UL16-binding proteins ULBP1, ULBP2, and ULBP3 in most of the leukemia cells analyzed...
  17. pmc The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells
    Jason M Norman
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Immunol 12:975-83. 2011
    ..Our results show that pathogen-induced deamination of cytidine and the DNA-damage response to virus-mediated repair of the incorporation of uridine enhance the recognition of HIV-infected cells by NK cells...
  18. ncbi Making sense of the diverse ligand recognition by NKG2D
    Sergei Radaev
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 169:6279-85. 2002
    ..further test this hypothesis and to distinguish between diverse recognition and promiscuous ligand binding, four ULBP3 interface mutations, H21A, E76A, R82M, and D169A, were generated to each disrupt a single hydrogen bond or salt ..
  19. ncbi Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid
    Alessandro Poggi
    Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
    Cancer Res 64:9172-9. 2004
    ..The Vdelta1 T lymphocytes studied were able to lyse the ULBP3(+) C1R B-cell line upon transfection with MIC-A...
  20. ncbi ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
    Claire L Sutherland
    Department of Oncology, Amgen Inc, Seattle, WA, 98119, USA
    Blood 108:1313-9. 2006
    ..Although binding of ULBP3 to murine NKG2D could not be demonstrated in vitro, ULBP3 can also stimulate antitumor responses, suggesting that ..
  21. doi Induction of NKG2D ligands and increased sensitivity of tumor cells to NK cell-mediated cytotoxicity by hematoporphyrin-based photodynamic therapy
    Min Ju Park
    Department of Biochemistry, Pusan National University School of Medicine, Yangsan 626 870, South Korea
    Immunol Invest 40:367-82. 2011
    ..surface expression of ULBP1 and ULBP2 genes in SNU-1 human gastric tumor cell line and MICA/B, ULBP1, ULBP2 and ULBP3 genes in SW-900 human lung cancer cell line...
  22. doi An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination
    Yoav Bauman
    The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cell Host Microbe 9:93-102. 2011
    ..Here we show that a viral miRNA identical in sequence between JCV and BKV targets the stress-induced ligand ULBP3, which is a protein recognized by the killer receptor NKG2D...
  23. doi MicroRNA based immunoevasion mechanism of human polyomaviruses
    Yoav Bauman
    The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
    RNA Biol 8:591-4. 2011
    ..This identical miRNA targets the stress-induced protein ULBP3, which is recognized by the killer receptor NKG2D and thus, through the usage of a miRNA, JCV and BKV avoid the ..
  24. doi Treatment of alopecia areata: "What is new on the horizon?"
    Maria K Hordinsky
    Department of Dermatology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Dermatol Ther 24:364-8. 2011
    ..Special attention is being given to the UL 16-binding protein (ULBP3) gene cluster on chromosome 6q25, as these genes make the NKG2D-activating ligand or signal that can trigger the ..
  25. doi Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function
    Heba Abdelrazik
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 41:3281-90. 2011
    ..expression of some relevant MSC surface molecules, namely the DNAM-1 ligands PVR and Nectin-2, the NKG2D ligand ULBP3, the adhesion molecules CD49d and αvβ3 and the fibroblast-associated protein...
  26. doi Methylation-specific ligation detection reaction (msLDR): a new approach for multiplex evaluation of methylation patterns
    Felix Bormann
    Institute of Pathology, University Medicine Charité, Charitéplatz1, 10117 Berlin, Germany
    Mol Genet Genomics 286:279-91. 2011
    ..Parallel analysis of HLA-A, HLA-B, STAT1, B2M, LMP2, LMP7, PA28α, TAP1, TAP2, TAPBP, ULBP2 and ULBP3 by msLDR in eight colorectal cancer cell lines showed preferential methylation at the HLA-B, ULBP2 and ULBB3 loci, ..
  27. pmc Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D
    Konstantina Eleme
    Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
    J Exp Med 199:1005-10. 2004
    ..Western blotting revealed that glycosylphosphatidylinositol (GPI)-anchored ULBP3 but not transmembrane MICA, MHC class I protein, or transferrin receptor, accumulated in detergent-resistant ..
  28. ncbi Structure and function of natural-killer-cell receptors
    Peter D Sun
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Immunol Res 27:539-48. 2003
    ..families, in particular, the structure and recognition between KIR2DL2 and HLA-Cw3, that between NKG2D and ULBP3, and that between CD16 and IgG Fc, considerable understandings have been achieved about their function and their ..
  29. ncbi Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein
    Alexander Rölle
    Microbiology and Tumor Biology Center and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    J Immunol 171:902-8. 2003
    ..However, while at a lower viral dose ULBP1 and 2 surface expression was completely inhibited compared to ULBP3, at a higher viral dose cell surface expression of ULBP1 and ULBP2 was delayed...
  30. ncbi [Matrine enhances the cytotoxic sensitivity of ABCG2high nasopharyngeal carcinoma cells to natural killer cells by inducing high expression of NKG2D receptor ligands]
    Yu Xian Huang
    Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:1329-32. 2009
    ....
  31. ncbi NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer
    A Cerwenka
    German Cancer Center DKFZ 0080 IM Neuenheimerfeld D 69120 Heidelberg 280 Germany
    Tissue Antigens 61:335-43. 2003
    ..Moreover, we describe how viruses and cancer have developed strategies to evade this recognition pathway...
  32. ncbi Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein
    Stefan A Welte
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, Tubingen, Germany
    Eur J Immunol 33:194-203. 2003
    ..However, solely MICA and ULBP3 reach the cellular surface to engage NKG2D, whereas MICB, ULBP1 and ULBP2 are selectively retained in the ..
  33. ncbi Generating isomorphous heavy-atom derivatives by a quick-soak method. Part II: phasing of new structures
    Peter D Sun
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Acta Crystallogr D Biol Crystallogr 58:1099-103. 2002
    ..type II transforming growth factor beta receptor (TBRII) and a natural killer cell receptor-ligand complex, NKG2D-ULBP3. In the case of TBRII, a crystal derivatized for only 10 min in saturated HgCl(2) provided adequate phasing for ..
  34. ncbi A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3
    Mirjana Radosavljevic
    INSERM CReS, Centre de Recherche d Immunologie et d Hématologie, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
    Genomics 79:114-23. 2002
    ..The involvement of orthologous mouse RAET1A-D/H60 in natural killer and T-cell activation through NKG2D engagement augurs a similar function for the human RAET1 proteins...
  35. pmc Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
    Lynn Petukhova
    Department of Dermatology, Columbia University, New York, New York 10032, USA
    Nature 466:113-7. 2010
    ..By probing the role of ULBP3 in disease pathogenesis, we also show that its expression in lesional scalp from patients with AA is markedly ..
  36. doi Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus
    Neil J Bennett
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    J Immunol 185:1093-102. 2010
    ..In this article, we show that the HCMV gene product UL142 can prevent cell surface expression of ULBP3 during infection...
  37. doi Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations
    Ayman Antoun
    School of Cancer Sciences, Birmingham University, Birmingham, United Kingdom
    Hum Immunol 71:610-20. 2010
    ..Interestingly, variation was focused within the RAET1E (ULBP4), RAET1L, and ULBP3 genes, whereas the ULBP1, ULBP2 and RAET1G (ULBP5) genes were highly conserved...
  38. ncbi TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells
    Günter Eisele
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 129:2416-25. 2006
    ..during malignant progression and selectively downregulates MICA, ULBP2 and ULBP4 expression, while MICB, ULBP1 and ULBP3 are unaffected...
  39. ncbi Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins
    Silvia Catellani
    Laboratory of Hematology, University of Genoa, Genoa, Italy
    Blood 109:2078-85. 2007
    ..with increased circulating Vdelta1 T lymphocytes, B cells expressing the UL-16-binding proteins (ULBPs) ULBP2 or ULBP3 or both were found in peripheral blood, bone marrow, or lymph nodes...
  40. ncbi Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
    Shlomo Nedvetzki
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3776-85. 2007
    ..ligands on macrophages: high doses of LPS induced transcription and surface expression of ULBP1, ULBP2, and ULBP3 and surface expression of constitutively transcribed MICA...
  41. ncbi DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
    Mattias Carlsten
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Cancer Res 67:1317-25. 2007
    ..DNAM-1) ligand PVR and sparse/heterogeneous expression of the NKG2D ligands MICA/MICB and ULBP1, ULBP2, and ULBP3. In line with the NK receptor ligand expression profiles, antibody-mediated blockade of activating receptor ..
  42. ncbi NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection
    Monia Draghi
    Department of Structural Biology, 299 Campus Drive West, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 178:2688-98. 2007
    ..Poly(I:C)-treated DCs did not express the UL16-binding protein 3 ligand for NKG2D, and in the absence of the influenza hemagglutinin there was no involvement of NKp46...
  43. ncbi Human natural killer lymphocytes through the engagement of natural cytotoxicity receptors and NKG2D can trigger self-aggression
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Autoimmun Rev 6:295-9. 2007
    ..Both types of SC bear the MHC-related molecule MIC-A and the UL16 binding protein ULBP3, which engagement with NKG2D, expressed by NK, is responsible for the delivery of lethal hit...
  44. ncbi RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity
    Wei Cao
    Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005 China
    J Biol Chem 282:18922-8. 2007
    ..ULBP1, ULBP2, ULBP3, and RAET1L link to membrane through glycosylphosphatidylinositol, whereas RAET1E and RAET1G contain transmembrane ..
  45. ncbi [Expression of NKG2D ligands on dendritic cells at different development stages and its effect on cytotoxicity of NK cells]
    San fang Tu
    Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:341-3, 347. 2008
    ..To investigate the expression of NKG2D ligands on dendritic cells(DC) at different development stages and its effect on cytotoxicity of natural killer(NK) cells...
  46. pmc Reliability of tumor markers, chemokines, and metastasis-related molecules in serum
    Faina Linkov
    University of Pittsburgh Cancer Institute, Division of Cancer Prevention and Population Science, 5150 Centre Ave, Room 466, Pittsburgh, PA 15224, USA
    Eur Cytokine Netw 20:21-6. 2009
    ..These included cancer antigens: CA 19-9, CA 72-4, MICA, S100, TTR, ULBP1, ULBP2, ULBP3; proteases: MMP 2, 3, 7, 12, 13; chemokines: MCP-3, MIF, MIG; adipokines: leptin and resistin; apoptotic factors: ..
  47. pmc Proteasome regulation of ULBP1 transcription
    James E Butler
    Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA
    J Immunol 182:6600-9. 2009
    ..HNSCC cells typically expressed MHC class I chain-related gene A (MICA), MICB, UL16-binding protein (ULBP)2, and ULBP3, but they were uniformly negative for cell surface ULBP1 and ULBP4...
  48. ncbi Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708, USA
    J Immunol 175:4611-7. 2005
    ..monocytes up-regulated expression of the NKG2D ligand, UL-16 binding protein (ULBP)1, but not expression of ULBP2, ULBP3, or MHC class I-related chain A or chain B...
  49. doi Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais
    Amornrat V Romphruk
    Blood Transfusion Center, Faculty of Medicine, Khon Kaen University KKU, Khon Kaen 40002, Thailand
    Immunogenetics 61:611-7. 2009
    ..These are ULBP1 or RAET1I, ULBP2 or RAET1H, ULBP3 or RAET1N, and RAET1L, which are glycosylinositol phospholipid (GPI)-linked glycoproteins and ULBP4 or RAET1E and ULBP5 or ..
  50. ncbi Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias
    Pegah Nowbakht
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Blood 105:3615-22. 2005
    ..Analysis of UL16-binding protein-1 (ULBP1), ULBP2, and ULBP3 ligands for NKG2D and of potential ligands for NKp30, NKp44, and NKp46 in healthy hematopoietic cells demonstrated ..
  51. doi ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients
    Roger W McGilvray
    Academic Division of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottingham, United Kingdom
    Int J Cancer 127:1412-20. 2010
    ..Patients whose tumors had high expression of RAET1E (p = 0.037), ULBP1 (p = 0.036) and ULBP3 (p = 0...
  52. pmc Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands
    Lola Fernández-Messina
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    J Biol Chem 285:8543-51. 2010
    ..and cellular approaches in both transfectant systems and tumor cell lines, this paper shows that ULBP1, ULBP2, and ULBP3 are released from cells with different kinetics and by distinct mechanisms...
  53. ncbi Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3
    S Radaev
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Immunity 15:1039-49. 2001
    ..In the NKG2D/ULBP3 complex, the structure of ULBP3 resembles the alpha1 and alpha2 domains of classical MHC molecules without a bound ..

Research Grants12

  1. Cigarette Smoke and Susceptibility to Influenza Infection
    Terry L Noah; Fiscal Year: 2010
    ..Knowledge obtained from these studies can be exploited to develop new therapeutic strategies aimed at mitigating respiratory virus infections and their effects in individuals chronically exposed to tobacco smoke. ..
  2. Diesel-Induced Alterations of Influenza Infectivity
    Terry L Noah; Fiscal Year: 2010
    ....
  3. Diesel-Induced Alterations of Influenza Infectivity
    Ilona Jaspers; Fiscal Year: 2007
    ..Data derived from these experiments will provide important insights into the molecular mechanisms by which exposure to DE could enhance the susceptibility to influenza infections. ..
  4. The role of NK cells in human M. Tuberculosis infection
    Ramakrishna Vankayalapati; Fiscal Year: 2009
    ..These findings will facilitate development of immunomodulatory strategies to boost the immune response to M. tuberculosis, including multidrug-resistant tuberculosis. ..