Research Topics

Genomes and Genes

Gene Symbol: UL45

Description: type 2 membrane protein; tegument-associated; possibly involved in membrane fusion

Alias: type 2 membrane protein, tegument-associated, possibly involved in membrane fusion, membrane protein UL45

Species: Human herpesvirus 2

Kolb A, Larsen I, Cuellar J, Brandt C. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. J Virol. 2015;89:6427-34 pubmed publisher
Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, et al. Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain. Virology. 2014;450-451:140-5 pubmed publisher

..Because HG52 virus is less virulent than other HSV-2 strains and may not be representative of wildtype HSV-2 strains, we propose that the HSV-2 SD90e genome serve as the new HSV-2 reference genome. ..
Petro C, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs W, et al. HSV-2 ?gD elicits Fc?R-effector antibodies that protect against clinical isolates. JCI Insight. 2016;1: pubmed

..Rapid clearance and the absence of latent virus suggest that ?gD-2 elicits sterilizing immunity. ..