Gene Symbol: UL42
Description: dsDNA-binding protein; involved in DNA replication
Alias: dsDNA-binding protein, involved in DNA replication, DNA polymerase processivity subunit
Species: Human herpesvirus 2

Top Publications

  1. Petro C, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs W, et al. HSV-2 ?gD elicits Fc?R-effector antibodies that protect against clinical isolates. JCI Insight. 2016;1: pubmed
    ..Rapid clearance and the absence of latent virus suggest that ?gD-2 elicits sterilizing immunity. ..
  2. Burrel S, Ait Arkoub Z, Agut H, Boutolleau D. Genotypic characterization of herpes simplex virus DNA polymerase UL42 processivity factor. Antiviral Res. 2012;93:199-203 pubmed publisher
    The herpes simplex virus (HSV) DNA polymerase is composed of the UL30 catalytic subunit and the UL42 processivity factor. The UL42 subunit increases the processivity of the polymerase along the DNA template during replication...
  3. Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, et al. Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain. Virology. 2014;450-451:140-5 pubmed publisher
    ..Because HG52 virus is less virulent than other HSV-2 strains and may not be representative of wildtype HSV-2 strains, we propose that the HSV-2 SD90e genome serve as the new HSV-2 reference genome. ..