UL4

Summary

Gene Symbol: UL4
Description: colocalizes with regulatory protein ICP22 and nuclear protein UL3 in small, dense nuclear bodies
Alias: colocalizes with regulatory protein ICP22 and nuclear protein UL3 in small, dense nuclear bodies, nuclear protein UL4
Species: Human herpesvirus 2

Top Publications

  1. McGeoch D, Cunningham C, McIntyre G, Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J Gen Virol. 1991;72 ( Pt 12):3057-75 pubmed
    ..The 5658 bp sequenced at the left end of HSV-2 UL contained coding regions for genes UL1 to UL4 plus part of UL5...
  2. McGeoch D, Moss H, McNab D, Frame M. DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. J Gen Virol. 1987;68 ( Pt 1):19-38 pubmed
    ..These data were interpreted to suggest, first, that HSV-2 US4 represents an ancient gene of alpha herpesviruses, and, more tentatively, that the evolution of the genes for gG and gD may have proceeded through a duplication event. ..
  3. Barnett B, Dolan A, Telford E, Davison A, McGeoch D. A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses. J Gen Virol. 1992;73 ( Pt 8):2167-71 pubmed publisher
    ..Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses...
  4. Everett R, Fenwick M. Comparative DNA sequence analysis of the host shutoff genes of different strains of herpes simplex virus: type 2 strain HG52 encodes a truncated UL41 product. J Gen Virol. 1990;71 ( Pt 6):1387-90 pubmed publisher
    ..The results show that the UL41 genes of strains G and 17 are 86% homologous and that the lack of shutoff by HG52 is likely to be explained by a frameshift mutation within its UL41 coding sequence...
  5. Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, et al. Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain. Virology. 2014;450-451:140-5 pubmed publisher
    ..Because HG52 virus is less virulent than other HSV-2 strains and may not be representative of wildtype HSV-2 strains, we propose that the HSV-2 SD90e genome serve as the new HSV-2 reference genome. ..

Scientific Experts