UL37

Summary

Gene Symbol: UL37
Description: type 1 membrane protein; involved in apoptosis; involved in gene regulation
Alias: type 1 membrane protein, involved in apoptosis, involved in gene regulation, envelope glycoprotein UL37
Species: Human herpesvirus 5

Top Publications

  1. Wyrwicz L, Rychlewski L. Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein. Acta Biochim Pol. 2008;55:67-73 pubmed
    ..application of protein structure prediction methods in assigning the function to a glycosylated domain encoded by UL37 of CMV (gpUL37, UL37x3)...
  2. Williamson C, Zhang A, COLBERG POLEY A. The human cytomegalovirus protein UL37 exon 1 associates with internal lipid rafts. J Virol. 2011;85:2100-11 pubmed publisher
    The human cytomegalovirus (HCMV) protein UL37 exon 1 (pUL37x1), also known as viral mitochondrion-localized inhibitor of apoptosis (vMIA), sequentially traffics from the endoplasmic reticulum (ER) through mitochondrion-associated ..
  3. Zhang A, Hildreth R, COLBERG POLEY A. Human cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of Bax at endoplasmic reticulum-mitochondrion contacts. J Virol. 2013;87:5657-68 pubmed publisher
    Human cytomegalovirus (HCMV) encodes the UL37 exon 1 protein (pUL37x1), which is the potent viral mitochondrion-localized inhibitor of apoptosis (vMIA), to increase survival of infected cells...
  4. Williamson C, COLBERG POLEY A. Intracellular sorting signals for sequential trafficking of human cytomegalovirus UL37 proteins to the endoplasmic reticulum and mitochondria. J Virol. 2010;84:6400-9 pubmed publisher
    Human cytomegalovirus UL37 antiapoptotic proteins, including the predominant UL37 exon 1 protein (pUL37x1), traffic sequentially from the endoplasmic reticulum (ER) through the mitochondrion-associated membrane compartment to the ..
  5. Bozidis P, Williamson C, Wong D, COLBERG POLEY A. Trafficking of UL37 proteins into mitochondrion-associated membranes during permissive human cytomegalovirus infection. J Virol. 2010;84:7898-903 pubmed publisher
    Human cytomegalovirus (HCMV) UL37 proteins traffic sequentially from the endoplasmic reticulum (ER) to the mitochondria...
  6. Seo J, Yaneva R, Hinson E, Cresswell P. Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science. 2011;332:1093-7 pubmed publisher
    ..This function of viperin, which was previously attributed to vMIA, suggests that HCMV has coopted viperin to facilitate the infectious process. ..
  7. Kaarb M, Ager Wick E, Osenbroch P, Kilander A, Skinnes R, M ller F, et al. Human cytomegalovirus infection increases mitochondrial biogenesis. Mitochondrion. 2011;11:935-45 pubmed publisher
    ..These results argue for a role of pUL37x1 beyond controlling apoptosis...