Gene Symbol: UL22
Description: type 1 membrane protein; contains a signal peptide; possible membrane fusogen; complexed with envelope glycoprotein L; involved in cell entry; involved in cell-to-cell spread
Alias: type 1 membrane protein, contains a signal peptide, possible membrane fusogen, complexed with envelope glycoprotein L, involved in cell entry, involved in cell-to-cell spread, envelope glycoprotein H
Species: Human herpesvirus 2
Cairns T, Friedman L, Lou H, Whitbeck J, Shaner M, Cohen G, et al
. N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. J Virol. 2007;81:5102-11 pubmed
..Additional mutagenesis identified L66 and L72 as important for function. Together, our results highlight several key gH residues: R39, Y41, W42, and D44 for gH transport and L66 and L72 for gH/gL structure and function...
Kolb A, Larsen I, Cuellar J, Brandt C. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. J Virol. 2015;89:6427-34 pubmed publisher
Chowdary T, Cairns T, Atanasiu D, Cohen G, Eisenberg R, Heldwein E. Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nat Struct Mol Biol. 2010;17:882-8 pubmed publisher
..Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target...
Atanasiu D, Cairns T, Whitbeck J, Saw W, Rao S, Eisenberg R, et al
. Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors. MBio. 2013;4: pubmed publisher
..Here, we show that a mutant form of gH/gL, gH?48/gL, can induce fusion of gB-expressing cells in the absence of gD and a gD receptor. Our study supports the concept that gB is the HSV fusogen and its activity is regulated by gH/gL. ..
Cairns T, Shaner M, Zuo Y, Ponce de Leon M, Baribaud I, Eisenberg R, et al
. Epitope mapping of herpes simplex virus type 2 gH/gL defines distinct antigenic sites, including some associated with biological function. J Virol. 2006;80:2596-608 pubmed publisher
..Several recognize important functional domains of gH2, gL2, or the complex. We suggest a common grouping scheme for all of the known MAbs against gH/gL of both HSV-1 and HSV-2...