Gene Symbol: UL18
Description: complexed 2:1 with capsid triplex subunit 1 to connect capsid hexons and pentons; involved in capsid morphogenesis
Alias: complexed 2:1 with capsid triplex subunit 1 to connect capsid hexons and pentons, involved in capsid morphogenesis, capsid triplex subunit 2
Species: Human herpesvirus 2
McGeoch D, Cunningham C, McIntyre G, Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J Gen Virol. 1991;72 ( Pt 12):3057-75 pubmed
..Properties of the LAT sequences in both HSV-1 and HSV-2 were consistent with LATs being generated as an intron excised from a longer transcript. ..
Barnett B, Dolan A, Telford E, Davison A, McGeoch D. A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses. J Gen Virol. 1992;73 ( Pt 8):2167-71 pubmed publisher
..Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses...
McGeoch D, Moss H, McNab D, Frame M. DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. J Gen Virol. 1987;68 ( Pt 1):19-38 pubmed
..These data were interpreted to suggest, first, that HSV-2 US4 represents an ancient gene of alpha herpesviruses, and, more tentatively, that the evolution of the genes for gG and gD may have proceeded through a duplication event. ..
Kolb A, Larsen I, Cuellar J, Brandt C. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. J Virol. 2015;89:6427-34 pubmed publisher
Petro C, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs W, et al
. HSV-2 ?gD elicits Fc?R-effector antibodies that protect against clinical isolates. JCI Insight. 2016;1: pubmed
..Rapid clearance and the absence of latent virus suggest that ?gD-2 elicits sterilizing immunity. ..
Everett R, Fenwick M. Comparative DNA sequence analysis of the host shutoff genes of different strains of herpes simplex virus: type 2 strain HG52 encodes a truncated UL41 product. J Gen Virol. 1990;71 ( Pt 6):1387-90 pubmed publisher
..The results show that the UL41 genes of strains G and 17 are 86% homologous and that the lack of shutoff by HG52 is likely to be explained by a frameshift mutation within its UL41 coding sequence...