Gene Symbol: UL1
Description: contains a signal peptide; complexed with envelope glycoprotein H; involved in cell entry; involved in cell-to-cell spread
Alias: contains a signal peptide, complexed with envelope glycoprotein H, involved in cell entry, involved in cell-to-cell spread, envelope glycoprotein L
Species: Human herpesvirus 2

Top Publications

  1. Cairns T, Friedman L, Lou H, Whitbeck J, Shaner M, Cohen G, et al. N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. J Virol. 2007;81:5102-11 pubmed
    ..Additional mutagenesis identified L66 and L72 as important for function. Together, our results highlight several key gH residues: R39, Y41, W42, and D44 for gH transport and L66 and L72 for gH/gL structure and function...
  2. McGeoch D, Moss H, McNab D, Frame M. DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. J Gen Virol. 1987;68 ( Pt 1):19-38 pubmed
    ..These data were interpreted to suggest, first, that HSV-2 US4 represents an ancient gene of alpha herpesviruses, and, more tentatively, that the evolution of the genes for gG and gD may have proceeded through a duplication event. ..
  3. McGeoch D, Cunningham C, McIntyre G, Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J Gen Virol. 1991;72 ( Pt 12):3057-75 pubmed
    ..The 5658 bp sequenced at the left end of HSV-2 UL contained coding regions for genes UL1 to UL4 plus part of UL5...
  4. Everett R, Fenwick M. Comparative DNA sequence analysis of the host shutoff genes of different strains of herpes simplex virus: type 2 strain HG52 encodes a truncated UL41 product. J Gen Virol. 1990;71 ( Pt 6):1387-90 pubmed publisher
    ..The results show that the UL41 genes of strains G and 17 are 86% homologous and that the lack of shutoff by HG52 is likely to be explained by a frameshift mutation within its UL41 coding sequence...
  5. Cairns T, Shaner M, Zuo Y, Ponce de Leon M, Baribaud I, Eisenberg R, et al. Epitope mapping of herpes simplex virus type 2 gH/gL defines distinct antigenic sites, including some associated with biological function. J Virol. 2006;80:2596-608 pubmed publisher
    ..Several recognize important functional domains of gH2, gL2, or the complex. We suggest a common grouping scheme for all of the known MAbs against gH/gL of both HSV-1 and HSV-2...
  6. Chowdary T, Cairns T, Atanasiu D, Cohen G, Eisenberg R, Heldwein E. Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nat Struct Mol Biol. 2010;17:882-8 pubmed publisher
    ..Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target...
  7. Kolb A, Larsen I, Cuellar J, Brandt C. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. J Virol. 2015;89:6427-34 pubmed publisher
  8. Atanasiu D, Cairns T, Whitbeck J, Saw W, Rao S, Eisenberg R, et al. Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors. MBio. 2013;4: pubmed publisher
    ..Here, we show that a mutant form of gH/gL, gH?48/gL, can induce fusion of gB-expressing cells in the absence of gD and a gD receptor. Our study supports the concept that gB is the HSV fusogen and its activity is regulated by gH/gL. ..
  9. Barnett B, Dolan A, Telford E, Davison A, McGeoch D. A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses. J Gen Virol. 1992;73 ( Pt 8):2167-71 pubmed publisher
    ..Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses...

More Information


  1. Hu K, He S, Xiao J, Li M, Luo S, Zhang M, et al. Interaction between herpesvirus entry mediator and HSV-2 glycoproteins mediates HIV-1 entry of HSV-2-infected epithelial cells. J Gen Virol. 2017;98:2351-2361 pubmed publisher
    ..Our findings provide a potential new mechanism underlying HSV-2 infection-enhanced HIV-1 mucosal transmission and may shed light on HIV-1 prevention. ..