UGT1A7

Summary

Gene Symbol: UGT1A7
Description: UDP glucuronosyltransferase family 1 member A7
Alias: UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G, UDP-glucuronosyltransferase 1-7, UDP glucuronosyltransferase 1 family, polypeptide A7, UDP glycosyltransferase 1 family, polypeptide A7, UDP-glucuronosyltransferase 1 family polypeptide A7s, UDP-glucuronosyltransferase 1-G, UDP-glucuronosyltransferase 1A7
Species: human
Products:     UGT1A7

Top Publications

  1. Pacheco P, Brilhante M, Ballart C, Sigalat F, Polena H, Cabral R, et al. UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the São Miguel Island Population (Azores, Portugal). Mol Diagn Ther. 2009;13:261-8 pubmed publisher
    ..Azores, Portugal) in order to determine the frequencies of polymorphisms and haplotypes in UGT1A1, UGT1A6, and UGT1A7, the co-occurrence of reduced enzyme activity UGT1A variants related to irinotecan toxicity, and to calculate the ..
  2. Verlaan M, Drenth J, Truninger K, Koudova M, Schulz H, Bargetzi M, et al. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. J Med Genet. 2005;42:e62 pubmed
    ..Recently, a UGT1A7 low detoxification activity allele, UGT1A7*3, has been linked to pancreatic cancer and alcoholic chronic ..
  3. Guillemette C, Ritter J, Auyeung D, Kessler F, Housman D. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics. 2000;10:629-44 pubmed
    ..In the present study, six single nucleotide polymorphisms were discovered in the first exon of the UGT1A7 gene, which codes for the putative substrate-binding domain, revealing a high structural heterogeneity at the UGT1 ..
  4. Zheng Z, Park J, Guillemette C, Schantz S, Lazarus P. Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. J Natl Cancer Inst. 2001;93:1411-8 pubmed
    UDP-glucuronosyltransferase 1A7 (UGT1A7) detoxifies several tobacco carcinogens...
  5. Vogel A, Kneip S, Barut A, Ehmer U, Tukey R, Manns M, et al. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Gastroenterology. 2001;121:1136-44 pubmed
    ..This study examines the association of UGT1A7 and UGT1A9 gene polymorphisms with hepatocellular carcinoma...
  6. Cecchin E, Innocenti F, D Andrea M, Corona G, De Mattia E, Biason P, et al. Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan. J Clin Oncol. 2009;27:2457-65 pubmed publisher
    ..In addition to UGT1A1*28, UGT1A1*60, UGT1A1*93, UGT1A7*3, and UGT1A9*22 were genotyped in 250 metastatic colorectal cancer patients, and associations with severe ..
  7. Innocenti F, Kroetz D, Schuetz E, Dolan M, Ramirez J, Relling M, et al. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. J Clin Oncol. 2009;27:2604-14 pubmed publisher
    ..On the basis of this exploratory analysis, common polymorphisms in genes encoding for ABC and SLC transporters may have a significant impact on the pharmacokinetics and pharmacodynamics of CPT-11. Confirmatory studies are required. ..
  8. Fujita K, Ando Y, Nagashima F, Yamamoto W, Eodo H, Araki K, et al. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. Cancer Chemother Pharmacol. 2007;60:515-22 pubmed
    The phenotypic effects of UGT1A7 and UGT1A9 genetic polymorphisms on the in vivo pharmacokinetics of irinotecan were examined. Eighty-four Japanese patients with cancer who received irinotecan-based chemotherapy were enrolled...
  9. Kohle C, Möhrle B, Munzel P, Schwab M, Wernet D, Badary O, et al. Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. Biochem Pharmacol. 2003;65:1521-7 pubmed
    ..Frequent haplotypes containing several UGT1 allelic variants should be taken into account in studies on the association between diseases, abnormal drug reactions, and UGT1 family polymorphisms. ..

More Information

Publications94

  1. Han J, Lim H, Shin E, Yoo Y, Park Y, Lee J, et al. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. J Clin Oncol. 2006;24:2237-44 pubmed
    To determine whether uridine diphosphate-glucuronosyltransferase 1A1, UGT1A7, and UGT1A9 polymorphisms affect the pharmacokinetics (PK) of irinotecan and treatment outcome of Korean patients with advanced non-small-cell lung cancer (NSCLC)..
  2. Liu J, Yang X, Liu G, Chang L, Zhang L, Song D. [Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer]. Zhonghua Yi Xue Za Zhi. 2009;89:3122-5 pubmed
    To investigate the association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer...
  3. Araki J, Kobayashi Y, Iwasa M, Urawa N, Gabazza E, Taguchi O, et al. Polymorphism of UDP-glucuronosyltransferase 1A7 gene: a possible new risk factor for lung cancer. Eur J Cancer. 2005;41:2360-5 pubmed
    ..The purpose of this study was to evaluate whether UGT1A7 polymorphisms are risk factors for lung cancer...
  4. Carlini L, Meropol N, Bever J, Andria M, Hill T, Gold P, et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005;11:1226-36 pubmed
    ..5%) demonstrating grade 3 or 4 neutropenia in the first two cycles. Low enzyme activity UGT1A7 genotypes, UGT1A7*2/*2 (six patients) and UGT1A7*3/*3 (seven patients), were significantly associated with ..
  5. Ockenga J, Vogel A, Teich N, Keim V, Manns M, Strassburg C. UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. Gastroenterology. 2003;124:1802-8 pubmed
    ..This study analyzes UGT1A7 gene polymorphisms in pancreatic diseases...
  6. Strassburg C, Vogel A, Kneip S, Tukey R, Manns M. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut. 2002;50:851-6 pubmed
    Genetic polymorphisms in the human UDP-glucuronosyltransferase-1A7 (UGT1A7) gene are detected and significantly correlated with sporadic colorectal carcinoma...
  7. Tseng C, Tang K, Lo H, Ker C, Teng H, Huang C. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. Am J Gastroenterol. 2005;100:1758-63 pubmed
    ..In this study, therefore, we evaluated the association between UGT1A7 genetic polymorphisms and HCC risk in southern Taiwan, where hepatitis B virus (HBV) and hepatitis C virus (HCV) ..
  8. Teng H, Huang M, Tang K, Yang S, Tseng C, Huang C. Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults. Clin Genet. 2007;72:321-8 pubmed
    ..Recent research also showed that carriage of UGT1A1*6 allele were significantly related with UGT1A7*3...
  9. van Es H, Bout A, Liu J, Anderson L, Duncan A, Bosma P, et al. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. Cytogenet Cell Genet. 1993;63:114-6 pubmed
    ..In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37. ..
  10. Huang M, Yang S, Lin M, Huang C. Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. World J Gastroenterol. 2005;11:797-802 pubmed
    Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer...
  11. Johnson A, Kavousi M, Smith A, Chen M, Dehghan A, Aspelund T, et al. Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet. 2009;18:2700-10 pubmed publisher
    ..In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated. ..
  12. Kang T, Kim H, Ju H, Kim J, Jeon Y, Lee H, et al. Genome-wide association of serum bilirubin levels in Korean population. Hum Mol Genet. 2010;19:3672-8 pubmed publisher
    ..Our result supports the idea that there are considerable ethnic differences in genetic association of bilirubin levels between Koreans and European-derived populations. ..
  13. van der Logt E, Bergevoet S, Roelofs H, van Hooijdonk Z, te Morsche R, Wobbes T, et al. Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. Carcinogenesis. 2004;25:2407-15 pubmed
    ..genotyped for polymorphisms in the important detoxification enzymes UDP-glucuronosyltransferase UGT1A1, UGT1A6, UGT1A7 and UGT1A8, and glutathione S-transferase GSTA1, GSTM1, GSTP1 and GSTT1...
  14. Wang Y, Kato N, Hoshida Y, Otsuka M, Taniguchi H, Moriyama M, et al. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. Clin Cancer Res. 2004;10:2441-6 pubmed
    Genetic polymorphisms of UDP-glucuronosyltransferase 1A7 (UGT1A7), which detoxifies endogenous and environmental carcinogens, have been reported to be associated with hepatocellular carcinoma (HCC) in German populations...
  15. Sanna S, Busonero F, Maschio A, McArdle P, Usala G, Dei M, et al. Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet. 2009;18:2711-8 pubmed publisher
    ..Thus, SLC01B3 appears to be involved in the regulation of serum bilirubin levels in healthy individuals and in some bilirubin-related disorders that are only partially explained by other known gene variants. ..
  16. Tukey R, Strassburg C. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000;40:581-616 pubmed
    ..The role of the UGTs in metabolism and different disease states in humans is the topic of this review. ..
  17. Tang K, Chiu H, Chen H, Eng H, Tsai C, Teng H, et al. Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. World J Gastroenterol. 2005;11:3250-4 pubmed
    ..the relationship between single nucleotide polymorphisms in the uridine-diphosphoglucuronosyltransferase (UGT) UGT1A7 and UGT1A1 genes and patients suffering from colorectal cancer (CRC)...
  18. Dong S, Zhang M, Niu H, Jiang K, Jiang J, Ma Y, et al. Upregulation of UDP-Glucuronosyltransferases 1a1 and 1a7 Are Involved in Altered Puerarin Pharmacokinetics in Type II Diabetic Rats. Molecules. 2018;23: pubmed publisher
    ..The messenger RNA (mRNA) and protein expression levels of Ugt1a1 and Ugt1a7 in rat livers and intestines were measured using qRT-PCR and western blot, respectively...
  19. Hoydal K, Jenssen B, Letcher R, Dam M, Arukwe A. Hepatic phase I and II biotransformation responses and contaminant exposure in long-finned pilot whales from the Northeastern Atlantic. Mar Environ Res. 2018;134:44-54 pubmed publisher
    ..The activity levels of phase II conjugating enzymes (uridine 5'-diphospho-glucuronosyltransferase [UDPGT], and glutathione S-transferase [GST]) were low...
  20. Minami H, Sai K, Saeki M, Saito Y, Ozawa S, Suzuki K, et al. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenet Genomics. 2007;17:497-504 pubmed
  21. Cox A, Ng M, Xu J, Langefeld C, Koch K, Dawson P, et al. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229:155-60 pubmed publisher
    ..These findings support a potential role for UGT1A genetic variants in risk for mortality in T2D. Further quantification of the extent of CVD risk conferred by UGT1A gene family variants in a high risk cohort with T2D is still required. ..
  22. Kakehi M, Ikenaka Y, Nakayama S, Kawai Y, Watanabe K, Mizukawa H, et al. Uridine Diphosphate-Glucuronosyltransferase (UGT) Xenobiotic Metabolizing Activity and Genetic Evolution in Pinniped Species. Toxicol Sci. 2015;147:360-9 pubmed publisher
    ..UGT1A2-1A5 and UGT1A7-1A10 are paralogous genes to UGT1A1 and UGTA6, respectively, and their numbers were lower in cat, ferret and ..
  23. Dunnick J, Nyska A. Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers. Exp Toxicol Pathol. 2009;61:1-12 pubmed publisher
    ..Treatment-related increases in liver weights, liver cytochrome P450 (1A1, 1A2, 2B) and UDPGT (rats only) levels, and liver lesions were seen in both rats and mice...
  24. Borentain P, Gerolami V, Ananian P, Garcia S, Noundou A, Botta Fridlund D, et al. DNA-repair and carcinogen-metabolising enzymes genetic polymorphisms as an independent risk factor for hepatocellular carcinoma in Caucasian liver-transplanted patients. Eur J Cancer. 2007;43:2479-86 pubmed
    We studied polymorphisms of three genes, UDP-glucuronosyltransferase1A7 (UGT1A7), Glutathione-S-transferaseM1 (GSTM1) and X-Ray Cross Complementing group 1 (XRCC1), involved in detoxification of xenobiotics or DNA-repair in a population ..
  25. Sun H, Wang H, Liu H, Zhang X, Wu B. Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences. Expert Opin Drug Metab Toxicol. 2014;10:1325-36 pubmed publisher
    ..UGT1A1, 1A9 and 2B7 (as well as the gastrointestinal enzymes UGT1A7 and 1A8) showed considerable activities...
  26. Solé M, Fortuny A, Mañanós E. Effects of selected xenobiotics on hepatic and plasmatic biomarkers in juveniles of Solea senegalensis. Environ Res. 2014;135:227-35 pubmed publisher
    ..reductases, carboxylesterases (CbEs) and the conjugation enzyme uridine diphosphate glucuronyltransferase (UDPGT)...
  27. Ribalta C, Sanchez Hernandez J, Sole M. Hepatic biotransformation and antioxidant enzyme activities in Mediterranean fish from different habitat depths. Sci Total Environ. 2015;532:176-83 pubmed publisher
    ..carboxylesterases (CbEs), and the phase-II conjugation activities uridine diphosphate glucuronyltransferase (UDPGT) and glutathione S-transferase (GST). Moreover, some antioxidant enzyme activities, i.e...
  28. Park S, Kong S, Rhee J, Park Y, Ryu K, Lee J, et al. Phase II study of a triplet regimen of S-1 combined with irinotecan and oxaliplatin in patients with metastatic gastric cancer: clinical and pharmacogenetic results. Ann Oncol. 2011;22:890-6 pubmed publisher
    ..with significantly higher incidence of grade 4 leukopenia (UGT1A1*6), neutropenia (UGT1A1*6, UGT1A6*2, and UGT1A7*3), grade 3/4 febrile neutropenia (UGT1A1*6), and grade 3 abdominal pain (UGT1A1*6)...
  29. Tang L, Ye L, Singh R, Wu B, Lv C, Zhao J, et al. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm. 2010;7:664-79 pubmed publisher
    ..The results also indicated that UGT1A1, UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2B7 are the most important six UGT isoforms for metabolizing the chosen flavones...
  30. Liu D, Li J, Gao J, Li Y, Yang R, Shen L. Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis. BMC Cancer. 2017;17:437 pubmed publisher
    ..The genotypes of UGT1A (UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A7*2, UGT1A7*3, UGT1A7*4 and UGT1A9*22) and DPYD (DPYD*5, DPYD c...
  31. Cao Y, Du Z, Zhu Z, Sun H, Fu Z, Yang K, et al. Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes. Chemosphere. 2017;185:983-990 pubmed publisher
    ..significant inhibition of UGT1A1, UGT1A3, UGT1A8, UGT1A10, UGT2B15, and UGT2B17, and limited inhibition of UGT1A6, UGT1A7 and UGT2B4. However, UGT1A9 was strongly inhibited by PAEs...
  32. Li L, Huang X, Peng J, Zheng M, Zhong D, Zhang C, et al. Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As). Phytomedicine. 2016;23:340-9 pubmed publisher
    ..Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides...
  33. Cotterchio M, Boucher B, Manno M, Gallinger S, Okey A, Harper P. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:3098-107 pubmed publisher
  34. Kim J, Hwang D, Moon J, Lee Y, Yoo J, Shin D, et al. Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations. Molecules. 2017;22: pubmed publisher
    ..II glucuronide (M6) was catalyzed by commonly expressed UGT1A1 and UGT1A9 and gastrointestinal-specific UGT1A7, UGT1A8, and UGT1A10, consistent with the higher intrinsic clearance values for the formation of M1, M2
  35. Lv X, Wang X, Hou J, Fang Z, Wu J, Cao Y, et al. Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases. Toxicol Appl Pharmacol. 2016;301:42-9 pubmed publisher
    ..The results demonstrated that both tolcapone and entacapone exhibited inhibitory effects on UGT1A1, UGT1A7, UGT1A9 and UGT1A10...
  36. Osawa K, Nakarai C, Akiyama M, Hashimoto R, Tsutou A, Takahashi J, et al. Association between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk. Asian Pac J Cancer Prev. 2012;13:2311-4 pubmed
    Genetic polymorphisms of uridine diphosphate-glucuronosyltransferases 1A6 (UGT1A6) and 1A7 (UGT1A7) may lead to genetic instability and colorectal cancer carcinogenesis...
  37. Piepoli A, Gentile A, Valvano M, Barana D, Oliani C, Cotugno R, et al. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. World J Gastroenterol. 2006;12:6343-8 pubmed
    To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC)...
  38. Jeong H, Kim J, Kong T, Choi W, Lee H. Comparative metabolism of honokiol in mouse, rat, dog, monkey, and human hepatocytes. Arch Pharm Res. 2016;39:516-530 pubmed publisher
    ..UGT1A1, 1A8, 1A9, 2B15, and 2B17 played major roles in M8 formation, whereas UGT1A7 and 1A9 played major roles in M9 formation...
  39. Levesque E, Benoit Biancamano M, Delage R, Couture F, Guillemette C. Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers. Pharmacogenomics. 2008;9:869-79 pubmed publisher
    ..This study further evaluates the impact of genetic polymorphisms at the UGT1A1, UGT1A7 and ABCC2 loci...
  40. De Mattia E, Cecchin E, Polesel J, Bignucolo A, Roncato R, Lupo F, et al. Genetic biomarkers for hepatocellular cancer risk in a caucasian population. World J Gastroenterol. 2017;23:6674-6684 pubmed publisher
    ..between ERCC1 rs3212986, CYP17A1 rs743572, GST-P1 rs1138272, and the previously described UGT1A7*3 predictive marker, played a role in the complex trait of HCC susceptibility...
  41. He Y, Folkerts E, Zhang Y, Martin J, Alessi D, Goss G. Effects on Biotransformation, Oxidative Stress, and Endocrine Disruption in Rainbow Trout (Oncorhynchus mykiss) Exposed to Hydraulic Fracturing Flowback and Produced Water. Environ Sci Technol. 2017;51:940-947 pubmed publisher
    ..The increased expression of cyp1a (2.49 ± 0.28-fold), udpgt (2.01 ± 0.31-fold), sod (1.67 ± 0.09-fold), and gpx (1.58 ± 0.10-fold) in raw sample exposure group (7...
  42. Benton M, Lea R, Macartney Coxson D, Bellis C, Carless M, Curran J, et al. Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate. BMC Genet. 2015;16:136 pubmed publisher
    ..GWAS of blood-based clinical traits in the Norfolk Island population has identified variants within the UDPGT family directly associated with serum bilirubin levels, which is in turn implicated with reduced risk of ..
  43. Lankisch T, Schulz C, Zwingers T, Erichsen T, Manns M, Heinemann V, et al. Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev. 2008;17:695-701 pubmed publisher
    ..The active CPT-11 metabolite 7-ethyl-10-hydroxycamptothecin is detoxified by several UGT1A proteins, which include UGT1A7 with a high specific activity that may contribute to the risk of irinotecan toxicity in Gilbert's syndrome ..
  44. Yilmaz L, Borazan E, Aytekin T, Baskonus I, Aytekin A, Oztuzcu S, et al. Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer. Asian Pac J Cancer Prev. 2015;16:1651-5 pubmed
    ..The aim of this study was to examine the relationship between UGT1A3 and UGT1A7 mRNA expression and pancreatic cancer...
  45. Crespo M, Sole M. The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system. Environ Sci Pollut Res Int. 2016;23:19229-36 pubmed publisher
    ..and BFCOD, carboxylesterase (CbE), glutathione S-transferase (GST) and uridine diphosphate glucuronyltransferase (UDPGT); and oxidative stress parameters such as catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (..
  46. Martinez Balibrea E, Abad A, Martinez Cardus A, Gines A, Valladares M, Navarro M, et al. UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. Br J Cancer. 2010;103:581-9 pubmed publisher
    ..Genotyping of TYMS (5'TRP and 3'UTR), UGT1A1(*)28, UGT1A9(*)22 and UGT1A7(*)3 was performed in 149 metastatic CRC patients treated with irinotecan/5FU as first-line chemotherapy enrolled ..
  47. Basu N, Kole L, Basu M, Chakraborty K, Mitra P, Owens I. The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J Biol Chem. 2008;283:23048-61 pubmed publisher
    ..to environmental changes, this report, combined with our earlier demonstration that specific phospho-groups in UGT1A7 determined substrate selections, suggests regulated phosphorylation allows adaptations regarding differential ..
  48. Miura M, Kagaya H, Satoh S, Inoue K, Saito M, Habuchi T, et al. Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008;30:559-64 pubmed publisher
    ..differences in the area under the plasma concentration-time curve (AUC) ratio of MPAG/MPA between UGT1A1, UGT1A6, UGT1A7, UGT1A8, and UGT1A9 I399C/T genotypes...
  49. Mackenzie P, Owens I, Burchell B, Bock K, Bairoch A, Belanger A, et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics. 1997;7:255-69 pubmed
    ..g. UGT1A1*30) consistent with the Human Gene Nomenclature Guidelines. It is anticipated that this UGT gene nomenclature system will require updating on a regular basis. ..
  50. Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, et al. Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants. Drug Metab Dispos. 2014;42:229-38 pubmed publisher
    ..Similarly, simultaneous expression of CYP3A4 increased the Vmax of UGT1A7*1 (wild type) and *2 (N129K and R131K), whereas the same was not observed in UGT1A7*3 (N129K, R131K, and W208R)...
  51. Rowbotham S, Illingworth N, Daly A, Veal G, Boddy A. Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans. Drug Metab Dispos. 2010;38:1211-7 pubmed publisher
    ..Further analysis revealed that UGT1A1, UGT1A3, UGT1A7, UGT1A8, and UGT1A9 were the major isoforms responsible for the glucuronidation of both substrates...
  52. Feng F, Liang G, Lu W, Miao X, Yu C, Tan W, et al. [Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer]. Ai Zheng. 2005;24:1085-90 pubmed
    UDP-glucuronosyltransferase 1A7 (UGT1A7) plays an important role in detoxification through catalyzing combination of glucuronic acid and tobacco carcinogens, including benzo [alpha] pyrene, nitrosamine, and heterocyclic amine PhIP, ..
  53. Milton J, Sebastiani P, Solovieff N, Hartley S, Bhatnagar P, Arking D, et al. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS ONE. 2012;7:e34741 pubmed publisher
    ..15 × 10(-4)). These results confirm that the UGT1A region is the major regulator of bilirubin metabolism in African Americans with sickle cell anemia, similar to what is observed in other ethnicities...
  54. Valenzuela Jiménez B, Gonzalez Sales M, Escudero Ortíz V, Martínez Navarro E, Pérez Ruixo C, Rebollo Liceaga J, et al. [Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G]. Farm Hosp. 2013;37:111-27 pubmed publisher
    To evaluate the influence of genetic polymorphism in UGT1A1, UGT1A7 and UGT1A9 on the population pharmacokinetics of irinotecan and its metabolites, SN-38 and SN-38G...
  55. Asai Y, Sakakibara Y, Nadai M, Katoh M. Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain. Drug Metab Pharmacokinet. 2017;32:286-292 pubmed publisher
    Because UDP-glucuronosyltransferase (Ugt) 1a6 and Ugt1a7 are highly expressed in the rat brain, changes in Ugt1a6 and Ugt1a7 expression may affect the pharmacokinetics of drugs and endogenous compounds in the brain...
  56. Basu N, Ciotti M, Hwang M, Kole L, Mitra P, Cho J, et al. Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004;279:1429-41 pubmed
    ..locus combined with Northern blot analysis and in situ hybridization, we determined the distribution of UGT1A1 and UGT1A7 through UGT1A10 mRNAs and found them for the first time segmentally distributed in the mucosal epithelia layer of ..
  57. Richardson V, Staskal D, Ross D, Diliberto J, DeVito M, Birnbaum L. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol Appl Pharmacol. 2008;226:244-50 pubmed
    ..There was no increase in hepatic T(4)-glucuronidation activity, but significant increases in hepatic Ugt1a1, Ugt1a7, and Ugt2b5 mRNA expression accompany significant decreases in T(4) concentrations at 100 mg/kg/day of BDE 47...
  58. Menard V, Girard H, Harvey M, Perusse L, Guillemette C. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. Hum Mutat. 2009;30:677-87 pubmed publisher
    ..Four haplotype blocks were inferred: Block 9/6 (UGT1A9, UGT1A7 and UGT1A6), Block 4 (UGT1A4), Block 3/1 (UGT1A3 and UGT1A1), and Block C (3'UTR)...
  59. Chen G, Ramos E, Adeyemo A, Shriner D, Zhou J, Doumatey A, et al. UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet. 2012;20:463-8 pubmed publisher
    ..In summary, UGT1A1 is a major locus influencing bilirubin levels and the results of this study promise to contribute to understanding of the etiology and treatment of hyperbilirubinaemia in African-ancestry populations. ..
  60. Villeneuve L, Girard H, Fortier L, Gagné J, Guillemette C. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther. 2003;307:117-28 pubmed
    ..studies revealed that along with UDP-glucuronosyltransferase (UGT) 1A1, the hepatic UGT1A9 and the extrahepatic UGT1A7 are involved in the biotransformation of the active and toxic metabolite of irinotecan, 7-ethyl-10-..
  61. Fan C, Jin M, Zhang Y, Song L, Xu H, Jiang Q, et al. [Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]. Zhonghua Yu Fang Yi Xue Za Zhi. 2006;40:13-7 pubmed
    To investigate the association between CYP1A1, GSTM1, T1, UGT1A7 polymorphisms and colorectal cancer risk...
  62. Vogel A, Ockenga J, Tukey R, Manns M, Strassburg C. Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited. Gastroenterology. 2011;140:1692-3 pubmed publisher
  63. Sharma R, Ahuja M, Panda N, Khullar M. Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians. Oral Dis. 2010;16:760-8 pubmed publisher
    To examine role of genetic variants of CYP2A13 and UGT1A7 genes, involved in activation and detoxification of tobacco carcinogens, with risk of head and neck cancer as well as to assess the potential modifying role of gene-gene and gene-..
  64. DISTEFANO J, Kingsley C, Craig Wood G, Chu X, Argyropoulos G, Still C, et al. Genome-wide analysis of hepatic lipid content in extreme obesity. Acta Diabetol. 2015;52:373-82 pubmed publisher
    ..These results replicate findings for several hepatic phenotypes in the setting of extreme obesity and implicate new loci that may play a role in the pathophysiology of hepatic lipid accumulation. ..
  65. Lacko M, Voogd A, van de Goor R, Roelofs H, Te Morsche R, Bouvy N, et al. Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland. Head Neck. 2016;38 Suppl 1:E717-23 pubmed publisher
    ..Prevalence of predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes was significantly higher in the patients with Warthin's tumors, but not in patients with ..
  66. Lampen A, Ebert B, Stumkat L, Jacob J, Seidel A. Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. Biochim Biophys Acta. 2004;1681:38-46 pubmed
    ..The gene expression of the Phase II enzymes UDP-glucuronosyltransferase 1A6 (UGT1A6) and UGT1A7 was also induced by these PAH but treatment with them had no effect on gene expression of sulfotransferases (SULT) ..
  67. Jylhävä J, Lyytikäinen L, Kahonen M, Hutri Kähönen N, Kettunen J, Viikari J, et al. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. PLoS ONE. 2012;7:e35426 pubmed publisher
    ..These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations. ..
  68. Wang Y, Duan H, Dai Y, Bin P, Cheng J, Pan Z, et al. Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers. J Occup Environ Med. 2009;51:682-9 pubmed publisher
    The aim of this study was to explore the relationship between UGT1A7 gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers...
  69. Kong S, Ki C, Yoo B, Kim J. UGT1A7 haplotype is associated with an increased risk of hepatocellular carcinoma in hepatitis B carriers. Cancer Sci. 2008;99:340-4 pubmed publisher
    The UGT1A7 gene encodes UDP-glucuronosyltransferase, a key enzyme catalyzing the glucuronidation of various carcinogens...
  70. Lu P, Chen M, Wu X, Gu J, Liu Y, Gu R. Genetic polymorphisms of UGT1A7 and cancer risk: evidence from 21 case-control studies. Cancer Invest. 2011;29:645-54 pubmed publisher
    The aim of our meta-analysis was to assess the association between UGT1A7 polymorphisms and cancer risk...
  71. Bellemare J, Rouleau M, Harvey M, Guillemette C. Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. J Biol Chem. 2010;285:3600-7 pubmed publisher
    ..UGT1A1, UGT1A7, and UGT1A8 were selected as candidates for these studies...
  72. Vogel A, Ockenga J, Ehmer U, Barut A, Kramer F, Tukey R, et al. Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer. Z Gastroenterol. 2002;40:497-502 pubmed
    ..In this study, UGT1A7 expression is demonstrated in oral, esophageal, and gastric tissue, which are the principle sites of proximal ..
  73. Urawa N, Kobayashi Y, Araki J, Sugimoto R, Iwasa M, Kaito M, et al. Linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms. Oncol Rep. 2006;16:801-6 pubmed
    ..have demonstrated the frequent co-existence of UGT1A1 *28 (-53 [TA]6>7) with other polymorphisms of UGT1A6 and UGT1A7. This finding suggests the occurrence of linkage disequilibrium (LD) among UGT1A1, UGT1A6 and UGT1A7 polymorphisms...
  74. Gu S, Zhang Z, Wan J, Jin X, Xia Z. Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population. J Toxicol Environ Health A. 2007;70:916-24 pubmed
    ..CYP1A1), cytochrome P-450 2D6 (CYP2D6), UDP-glucuronosyltransferase 1A6 (UGT1A6), UDP-glucuronosyltransferase1A7 (UGT1A7), and sulfotransferase 1A1 (SULT1A1), were studied for their roles in human susceptibility to benzene poisoning...
  75. te Morsche R, Drenth J, Truninger K, Schulz H, Kage A, Landt O, et al. UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. Pharmacogenomics J. 2008;8:34-41 pubmed
    ..Genetic variations reducing the activity of UGT1A7 have been associated with various gastrointestinal cancers...
  76. Yu B, Zheng Y, Alexander D, Morrison A, Coresh J, Boerwinkle E. Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet. 2014;10:e1004212 pubmed publisher
    ..These results highlight the value of using endophenotypes proximal to gene function to discover new insights into biology and disease pathology. ..
  77. Joseph T, Wang S, Liu X, Kulkarni K, Wang J, Xu H, et al. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm. 2007;4:883-94 pubmed
    ..Using 12 human UGT isoforms, we showed that UGT1A7, UGT1A8, and UGT1A9 were mainly responsible for the formation of metabolite 1, whereas UGT1A1, UGT1A8, and UGT1A10 ..
  78. Machida H, Tsukamoto K, Wen C, Shikuwa S, Isomoto H, Mizuta Y, et al. Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene. World J Gastroenterol. 2005;11:4833-7 pubmed
    ..and distribution of N-acetyltransferase 2 (NAT2) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD)...
  79. Butler L, Duguay Y, Millikan R, Sinha R, Gagné J, Sandler R, et al. Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1626-32 pubmed
    The UDP-glucuronosyltransferase 1A7 (UGT1A7) gene is polymorphic and encodes an enzyme involved in the detoxification of heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH)...
  80. Brand W, Boersma M, Bik H, Hoek van den Hil E, Vervoort J, Barron D, et al. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab Dispos. 2010;38:617-25 pubmed publisher
    ..UGT1A9, UGT1A1, UGT1A7, UGT1A8, and UGT1A3 are the major enzymes catalyzing hesperetin glucuronidation, the latter only producing 7-O-..
  81. Tang K, Lee C, Teng H, Huang M, Huang C. UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. Biochem Biophys Res Commun. 2008;366:643-8 pubmed
    ..Since the pathogenesis of liver cirrhosis is not dissimilar to that of HCC, we hypothesized that UGT1A7 genetic polymorphisms may be associated with liver cirrhosis...
  82. Operaña T, Tukey R. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007;282:4821-9 pubmed
    ..This technique demonstrated that UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 self-oligomerize (homodimerize)...
  83. Stucker I, Loriot M, N koutchou G, Cenee S, Bodin L, Mulot C, et al. UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?. BMC Cancer. 2007;7:214 pubmed
    We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC)...