UGT1A6

Summary

Gene Symbol: UGT1A6
Description: UDP glucuronosyltransferase family 1 member A6
Alias: GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F, UDP-glucuronosyltransferase 1-6, UDP glucuronosyltransferase 1 family, polypeptide A6, UDP glycosyltransferase 1 family, polypeptide A6, UDP-glucuronosyltransferase 1 family polypeptide A6s, UDP-glucuronosyltransferase 1-F, UDP-glucuronosyltransferase 1A6, UGT-1F, UGT1*6, UGT1-06, UGT1.6, phenol-metabolizing UDP-glucuronosyltransferase
Species: human
Products:     UGT1A6

Top Publications

  1. Ciotti M, Marrone A, Potter C, Owens I. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Pharmacogenetics. 1997;7:485-95 pubmed
    Two missense mutations were uncovered in the UGT1A6 (HLUG P1) cDNA which codes for a human phenol-metabolizing UDP-glucuronosyltransferase...
  2. Nagar S, Zalatoris J, Blanchard R. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004;14:487-99 pubmed
    ..The UGT1A6 protein is expressed predominantly in liver and metabolizes small phenolic drugs including acetaminophen, ..
  3. Johnson A, Kavousi M, Smith A, Chen M, Dehghan A, Aspelund T, et al. Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet. 2009;18:2700-10 pubmed publisher
    ..In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated. ..
  4. Kang T, Kim H, Ju H, Kim J, Jeon Y, Lee H, et al. Genome-wide association of serum bilirubin levels in Korean population. Hum Mol Genet. 2010;19:3672-8 pubmed publisher
    ..Our result supports the idea that there are considerable ethnic differences in genetic association of bilirubin levels between Koreans and European-derived populations. ..
  5. Ritter J, Crawford J, Owens I. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem. 1991;266:1043-7 pubmed
    ..These cDNAs which encode functional bilirubin UDP-glucuronosyltransferases will allow the isolation of an appropriate gene to develop a gene therapy model for patients which have the totally deficient trait. ..
  6. Saeki M, Saito Y, Jinno H, Sai K, Kaniwa N, Ozawa S, et al. Genetic polymorphisms of UGT1A6 in a Japanese population. Drug Metab Pharmacokinet. 2005;20:85-90 pubmed
    ..Then, 11 haplotypes in UGT1A6 were estimated...
  7. Sanna S, Busonero F, Maschio A, McArdle P, Usala G, Dei M, et al. Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet. 2009;18:2711-8 pubmed publisher
    ..Thus, SLC01B3 appears to be involved in the regulation of serum bilirubin levels in healthy individuals and in some bilirubin-related disorders that are only partially explained by other known gene variants. ..
  8. Tukey R, Strassburg C. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000;40:581-616 pubmed
    ..The role of the UGTs in metabolism and different disease states in humans is the topic of this review. ..
  9. Chan A, Tranah G, Giovannucci E, Hunter D, Fuchs C. Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. J Natl Cancer Inst. 2005;97:457-60 pubmed
    Genetic variation in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) enzyme is associated with impaired metabolism of aspirin...

More Information

Publications128 found, 100 shown here

  1. Pacheco P, Brilhante M, Ballart C, Sigalat F, Polena H, Cabral R, et al. UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the São Miguel Island Population (Azores, Portugal). Mol Diagn Ther. 2009;13:261-8 pubmed publisher
    ..Miguel Island (Azores, Portugal) in order to determine the frequencies of polymorphisms and haplotypes in UGT1A1, UGT1A6, and UGT1A7, the co-occurrence of reduced enzyme activity UGT1A variants related to irinotecan toxicity, and to ..
  2. Krishnaswamy S, Hao Q, Al Rohaimi A, Hesse L, von Moltke L, Greenblatt D, et al. UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation. J Pharmacol Exp Ther. 2005;313:1331-9 pubmed
    ..studies were conducted using a well characterized human liver bank (n = 54) and serotonin glucuronidation as a UGT1A6-specific phenotype marker...
  3. Kohle C, Möhrle B, Munzel P, Schwab M, Wernet D, Badary O, et al. Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. Biochem Pharmacol. 2003;65:1521-7 pubmed
    ..Furthermore, co-occurrence of UGT1A1*28 and UGT1A6*2 has been observed...
  4. Krishnaswamy S, Hao Q, von Moltke L, Greenblatt D, Court M. Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Drug Metab Dispos. 2004;32:862-9 pubmed
    ..In this study, the contribution of UGT1A6 to the glucuronidation of endogenous structural analogs of serotonin, including 5-hydroxytryptophol, N-..
  5. Li L, Huang X, Peng J, Zheng M, Zhong D, Zhang C, et al. Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As). Phytomedicine. 2016;23:340-9 pubmed publisher
    ..Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides...
  6. Zapletal O, Prochazkova J, Dubec V, Hofmanova J, Kozubik A, Vondracek J. Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models. Toxicology. 2018;412:1-11 pubmed publisher
    ..In some cases (NAT2, UGT1 A1), this was linked to inhibition of histone deacetylases (HDAC), as confirmed by using HDAC inhibitor ..
  7. Kwon S, Kim J, Jeong H, Cho Y, Oh S, Lee H. Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5'-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. Molecules. 2016;21: pubmed publisher
    ..At 200 µM, it weakly inhibited UGT1A1-catalyzed SN-38 glucuronidation, UGT1A6-catalyzed N-acetylserotonin glucuronidation, and UGT1A9-catalyzed mycophenolic acid glucuronidation, with IC50 ..
  8. Kim J, Kwon S, Kong T, Cheong J, Kim H, In M, et al. AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5'-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. Molecules. 2017;22: pubmed publisher
    ..1 μM. It negligibly inhibited CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2D6, UGT1A1, UGT1A4, UGT1A6, and UGT1A9 activities at 50 μM in human liver microsomes...
  9. González Mira A, Varo I, Sole M, Torreblanca A. Drugs of environmental concern modify Solea senegalensis physiology and biochemistry in a temperature-dependent manner. Environ Sci Pollut Res Int. 2016;23:20937-20951 pubmed
    ..BFCOD)) and uridine diphosphate glucuronosyltransferase (UDPGT)...
  10. Fabian E, Wang X, Engel F, Li H, Landsiedel R, van Ravenzwaay B. Activities of xenobiotic metabolizing enzymes in rat placenta and liver in vitro. Toxicol In Vitro. 2016;33:174-9 pubmed publisher
    ..CYP1A), 7-pentylresorufin-O-dealkylase (CYP2B), 7-benzylresorufin-O-dealkylase (CYP2B, 2C and 3 A), UGT1, UGT2 and GST in placenta, indicating that the placental activity of these enzymes was well below their hepatic ..
  11. Merrick B, Phadke D, Auerbach S, Mav D, Stiegelmeyer S, Shah R, et al. RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats. PLoS ONE. 2013;8:e61768 pubmed publisher
    ..were found and exon refinements were made including AFB1 exon-specific induction of homologous family members, Ugt1a6 and Ugt1a7c...
  12. Gleich A, Kaiser B, Honscha W, Fuhrmann H, Schoeniger A. Evaluation of the hepatocyte-derived cell line BFH12 as an in vitro model for bovine biotransformation. Cytotechnology. 2019;71:231-244 pubmed publisher
    ..RT-PCR revealed the expression of cytochromes 1A1, 1A2, 3A4 and phase II enzymes UGT1A1, UGT1A6 and GSTM1. Immunofluorescence demonstrated efflux transporters ABCG2 and ABCC1...
  13. Collier A, Yamauchi Y, Sato B, Rougée L, Ward M. UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst. Drug Metab Dispos. 2014;42:1921-5 pubmed publisher
    ..Western blots demonstrated the presence of Ugt1a6 but not Ugt1a1, Ugt1a3, Ugt1a4, or Ugt1a9. The Ugt2b proteins were not detected by either assay...
  14. Kong T, Kim J, Kwon S, Cheong J, Kim H, In M, et al. Inhibition of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferases by MAM-2201 in human liver microsomes. Arch Pharm Res. 2017;40:727-735 pubmed publisher
    ..liver microsomes, MAM-2201 (50 µM) negligibly inhibited CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2D6, UGT1A1, UGT1A4, UGT1A6, UGT1A9, and UGT2B7...
  15. Benton M, Lea R, Macartney Coxson D, Bellis C, Carless M, Curran J, et al. Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate. BMC Genet. 2015;16:136 pubmed publisher
    ..GWAS of blood-based clinical traits in the Norfolk Island population has identified variants within the UDPGT family directly associated with serum bilirubin levels, which is in turn implicated with reduced risk of ..
  16. Cengiz B, Yumrutas O, Bozgeyik E, Borazan E, Igci Y, Bozgeyik I, et al. Differential expression of the UGT1A family of genes in stomach cancer tissues. Tumour Biol. 2015;36:5831-7 pubmed publisher
    ..No expression changes were observed in UGT1A4. Also, UGT1A6 transcription variants were significantly upregulated in stomach cancer tissues compared to normal stomach tissue...
  17. Heo J, Nguyen P, Kim W, Phuc N, Liu K. Inhibitory Effect of Selaginellins from Selaginella tamariscina (Beauv.) Spring against Cytochrome P450 and Uridine 5'-Diphosphoglucuronosyltransferase Isoforms on Human Liver Microsomes. Molecules. 2017;22: pubmed publisher
    ..These two selaginellins had low inhibitory potential against CYP1A2, CYP2A6, CYP2E1, and UGT1A6 (IC50 > 25 μM)...
  18. Papageorgiou I, Freytsis M, Court M. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochem Pharmacol. 2016;117:78-87 pubmed publisher
    ..by 40%) and mRNA (by 10%), as well as enzyme activity and/or mRNA of AhR regulated enzymes including UGT1A1, UGT1A6, and CYP1A2, without affecting UGT2B7, which is not regulated by AhR...
  19. Papageorgiou I, Court M. Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach. Biochem Pharmacol. 2017;137:93-106 pubmed publisher
    ..miR-141-3p, miR-200a-3p, and miR-376b-3p mimics into LS180 human intestinal cells showed repression of UGT1A1 and UGT1A6 mediated glucuronidation and mRNA without affecting UGT2B7 activity or mRNA...
  20. Kaplanoglu E, Chapman P, Scott I, Donly C. Overexpression of a cytochrome P450 and a UDP-glycosyltransferase is associated with imidacloprid resistance in the Colorado potato beetle, Leptinotarsa decemlineata. Sci Rep. 2017;7:1762 pubmed publisher
    ..CYP4Q7), one ATP binding cassette (ABC) transporter (ABC-G), one esterase (EST1), and two UDP-glycosyltransferases (UGT1 and UGT2)...
  21. Collier A, Thévenon A, Goh W, Hiraoka M, Kendal Wright C. Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term. Eur J Drug Metab Pharmacokinet. 2015;40:471-80 pubmed publisher
    ..Although UGT1A6 mRNA was lower in PE (P < 0...
  22. Li C, Renaud H, Klaassen C, Cui J. Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors. Drug Metab Dispos. 2016;44:1038-49 pubmed publisher
    ..and Gstm3 by PCN; 2) during adolescent age, the highest fold increase in the mRNA expression was observed for Ugt1a6 and Mrp4 by TCDD, Cyp2b10, Ugt2b34, and Ugt2b35 by TCPOBOP, as well as Gsta1, Gsta4, Sult1e1, Ugt1a1, Mrp3, and ..
  23. You B, Gong E, Choi Y. Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity. Molecules. 2018;23: pubmed publisher
    ..83, 43.9, 0.758, and 0.279 μM, respectively. Sauchinone also noncompetitively inhibited UGT1A6 and 2B7 with Ki values of 1.08 and 0.524 μM, respectively...
  24. Tannous A, Pisoni G, Hebert D, Molinari M. N-linked sugar-regulated protein folding and quality control in the ER. Semin Cell Dev Biol. 2015;41:79-89 pubmed publisher
    ..polypeptides are recognized by the ER quality control key player UDP-glucose glycoprotein glucosyltransferase 1 (UGT1), re-glucosylated and re-addressed to the CNX/CRT chaperone binding cycle to provide additional opportunity for the ..
  25. Hoydal K, Jenssen B, Letcher R, Dam M, Arukwe A. Hepatic phase I and II biotransformation responses and contaminant exposure in long-finned pilot whales from the Northeastern Atlantic. Mar Environ Res. 2018;134:44-54 pubmed publisher
    ..The activity levels of phase II conjugating enzymes (uridine 5'-diphospho-glucuronosyltransferase [UDPGT], and glutathione S-transferase [GST]) were low...
  26. Troberg J, Järvinen E, Muniz M, Sneitz N, Mosorin J, Hagström M, et al. Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity. Drug Metab Dispos. 2015;43:107-18 pubmed publisher
    ..It may be concluded that, perhaps with the exception of UGT1A6, high similarities in substrate specificity between individual dog and human UGTs of subfamily 1A are rare or ..
  27. Shi B, Su Y, Chang S, Sun Y, Meng X, Shan A. Vitamin C protects piglet liver against zearalenone-induced oxidative stress by modulating expression of nuclear receptors PXR and CAR and their target genes. Food Funct. 2017;8:3675-3687 pubmed publisher
    ..CAR), phase I metabolic enzyme genes (CYP1A1, CYP1A2, CYP1A6) and phase II metabolic enzyme genes (UGT1A1, UGT1A3, UGT1A6)...
  28. Romand S, Spaggiari D, Marsousi N, Samer C, Desmeules J, Daali Y, et al. Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases. J Pharm Biomed Anal. 2017;144:129-137 pubmed publisher
    ..Incubations of HLM with phase I and phase II drug probes showed that oxycodone mainly decreased the in vitro activities of CYP2D6, CYP3A4/5, UGT1A3, UGT1A6 and UGT2B subfamily with an important impact on UGT2B7.
  29. Fay M, Nguyen M, Snouwaert J, Dye R, Grant D, Bodnar W, et al. Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family. Drug Metab Dispos. 2015;43:1838-46 pubmed publisher
    ..We demonstrate the utility of these animals by defining for the first time the in vivo contributions of the UGT1 and UGT2 families to glucuronidation of the environmental estrogenic agent bisphenol A (BPA)...
  30. Wang H, Yan T, Xie Y, Zhao M, Che Y, Zhang J, et al. Mechanism-based inhibitory and peroxisome proliferator-activated receptor α-dependent modulating effects of silybin on principal hepatic drug-metabolizing enzymes. Drug Metab Dispos. 2015;43:444-54 pubmed publisher
    ..characterized with significantly repressed expression of PPARα targeting genes, including L-FABP, ACOX1, and UGT1A6. This study suggests that silybin, despite its low bioavailability, may inhibit enzyme activities of multiple DMEs ..
  31. Levi F, Karaboué A, Saffroy R, Desterke C, Boige V, Smith D, et al. Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228). Br J Cancer. 2017;117:965-973 pubmed publisher
    ..rs1045642) and SLC0B3 (rs4149117 and rs7311358); and diarrhoea with CYP2C9 (rs1057910), CYP2C19 (rs3758581), UGT1A6 (rs4124874) and SLC22A1 (rs72552763). VKORC1, NAT2 and ABCB1 variants predicted for HAI efficacy...
  32. Chang V, Wang J. Pharmacogenetics of Chemotherapy-Induced Cardiotoxicity. Curr Oncol Rep. 2018;20:52 pubmed publisher
    ..patients with an indication for doxorubicin or daunorubicin therapy for RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 variants is recommended. There is no recommendation regarding testing in adults...
  33. Linschoten M, Teske A, Cramer M, van der Wall E, Asselbergs F. Chemotherapy-Related Cardiac Dysfunction: A Systematic Review of Genetic Variants Modulating Individual Risk. Circ Genom Precis Med. 2018;11:e001753 pubmed publisher
    ..and function), RARG rs2229774 (topoisomerase-2β expression), SLC28A3 rs7853758 (drug transport), UGT1A6 rs17863783 (drug metabolism), and 1 intergenic variant (rs28714259)...
  34. Liu C, Bian J, Jiang F, Shen F. [Genetic polymorphism of UDP-glucuronosyltransferase 1F and susceptibility to hepatocellular carcinoma]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002;19:324-8 pubmed
    To study the genetic polymorphisms of UDP-glucuronosyltransferase 1F(UGT1F) and the relationship between polymorphisms and susceptibility to hepatocellular carcinoma (HCC)...
  35. Liu S, Zhao T, Song B, Zhou J, Wang T. Comparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver Cells. PLoS ONE. 2016;11:e0147991 pubmed publisher
    ..in three independent trials, among which alphafetoprotein (AFP), UDP-glucose: glycoprotein glucosyltransferase 1 (UGT1) and HCV NS4B were further validated as novel E2 binding partners...
  36. Berkhout M, Roelofs H, te Morsche R, Dekker E, van Krieken J, Nagengast F, et al. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. Br J Surg. 2008;95:499-505 pubmed
    ..5'-diphosphate glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs): UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A10, UGT2B4, UGT2B7, UGT2B15, GSTA1, GSTP1, GSTM1 and GSTT1...
  37. Yang K, Fu Z, Cao Y, Li S, Du Z, Sun X, et al. New insights for risks of chlorophenols (CPs) exposure: Inhibition of UDP-glucuronosyltransferases (UGTs). Chemosphere. 2018;206:9-16 pubmed publisher
    ..Pentachlorophenol (PCP) was chosen as the representative CPs to determine the IC50 value towards UGT1A6, UGT1A9 and UGT2B7. IC50 was calculated to be 0.33??M, 0.24??M and 31...
  38. Oussalah A, Bosco P, Anello G, Spada R, Guéant Rodriguez R, Chery C, et al. Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article. Medicine (Baltimore). 2015;94:e925 pubmed publisher
    ..27 × 10(-34)), as well as unconjugated, and conjugated bilirubin levels. We also identified UGT1A6 variants in association with total (rs6759892, p.Ser7Ala, P = 1...
  39. Du Z, Cao Y, Li S, Hu C, Fu Z, Huang C, et al. Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters. Chemosphere. 2018;197:7-13 pubmed publisher
    ..100??M phthalate monoesters exhibited negligible inhibition towards the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A10, UGT2B4, UGT2B7, UGT2B15 and UGT2B17...
  40. Tannous A, Patel N, Tamura T, Hebert D. Reglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation. Mol Biol Cell. 2015;26:390-405 pubmed publisher
    UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) is a central quality control gatekeeper in the mammalian endoplasmic reticulum (ER)...
  41. Audet Delage Y, Rouleau M, Rouleau M, Roberge J, Miard S, Picard F, et al. Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. Mol Pharmacol. 2017;91:167-177 pubmed publisher
    Alternative splicing at the human glucuronosyltransferase 1 gene locus (UGT1) produces alternate isoforms UGT1A_i2s that control glucuronidation activity through protein-protein interactions...
  42. Bočkor L, Bortolussi G, Vodret S, Iaconcig A, Jašprová J, Zelenka J, et al. Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia. Hum Mol Genet. 2017;26:145-157 pubmed publisher
    ..To this end, we mated Abcb1a/b-/- and Abcc1-/- strains with Ugt1-/- mice, which develop severe neonatal hyperbilirubinemia...
  43. Liu X, Tam V, Hu M. Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA. Mol Pharm. 2007;4:873-82 pubmed
    ..The results showed that UGT1A6 activities (as measured by p-nitrophenol glucuronidation) and expression were typically decreased 60-80% by siRNA ..
  44. van Oijen M, Koetsier M, Laheij R, Roelofs H, Te Morsche R, Peters W, et al. Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage. Drug Metab Lett. 2009;3:199-204 pubmed
    UDP-glucuronosyltransferase 1A6 (UGT1A6) is involved in metabolizing non-steroidal anti-inflammatory drugs (NSAIDs)...
  45. Miyake Y, Hirose R, Isobe T, Hanioka N. Molecular cloning and functional analysis of minipig UDP-glucuronosyltransferase 1A6. Xenobiotica. 2016;46:193-9 pubmed publisher
    1. UDP-glucuronosyltransferase 1A6 (UGT1A6) plays important roles in the glucuronidation of numerous drugs, environmental pollutants, and endogenous substances...
  46. Leger K, Cushing Haugen K, Hansen J, Fan W, Leisenring W, Martin P, et al. Clinical and Genetic Determinants of Cardiomyopathy Risk among Hematopoietic Cell Transplantation Survivors. Biol Blood Marrow Transplant. 2016;22:1094-1101 pubmed publisher
    ..among early-onset cardiomyopathy cases, including rs1786814 in CELF4, rs2232228 in HAS3, and rs17863783 in UGT1A6. None of these markers were associated with risk of late-onset cardiomyopathy...
  47. Cao Y, Du Z, Zhu Z, Sun H, Fu Z, Yang K, et al. Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes. Chemosphere. 2017;185:983-990 pubmed publisher
    ..no significant inhibition of UGT1A1, UGT1A3, UGT1A8, UGT1A10, UGT2B15, and UGT2B17, and limited inhibition of UGT1A6, UGT1A7 and UGT2B4. However, UGT1A9 was strongly inhibited by PAEs...
  48. Asai Y, Sakakibara Y, Nadai M, Katoh M. Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain. Drug Metab Pharmacokinet. 2017;32:286-292 pubmed publisher
    Because UDP-glucuronosyltransferase (Ugt) 1a6 and Ugt1a7 are highly expressed in the rat brain, changes in Ugt1a6 and Ugt1a7 expression may affect the pharmacokinetics of drugs and endogenous compounds in the brain...
  49. Chang E, Birmann B, Kasperzyk J, Conti D, Kraft P, Ambinder R, et al. Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2009;18:976-86 pubmed publisher
    ..In conclusion, genetic variation in the NF-kappaB pathway seems to influence risk of HL. Pooled studies are needed to detect any heterogeneity in the association with NF-kappaB across HL subgroups, including aspirin users and nonusers. ..
  50. Wang Y, Gao L, Liu Y, Huang N, Xu S, Ma D. [Effect of UGTIA6 A541G genetic polymorphism on the metabolism of valproic acid in Han epileptic children from Henan]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12:429-32 pubmed
    ..There were no significant differences in serum concentrations of valproic acid among the three groups. UGT1A6 A541G gene polymorphism does not influence serum concentrations of valproic acid in Han epileptic children...
  51. Milton J, Sebastiani P, Solovieff N, Hartley S, Bhatnagar P, Arking D, et al. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS ONE. 2012;7:e34741 pubmed publisher
    ..SNPs in UGT1A1, UGT1A3, UGT1A6, UGT1A8 and UGT1A10, different isoforms within the UGT1A locus, were identified (most significant rs887829, p = 9...
  52. DISTEFANO J, Kingsley C, Craig Wood G, Chu X, Argyropoulos G, Still C, et al. Genome-wide analysis of hepatic lipid content in extreme obesity. Acta Diabetol. 2015;52:373-82 pubmed publisher
    ..These results replicate findings for several hepatic phenotypes in the setting of extreme obesity and implicate new loci that may play a role in the pathophysiology of hepatic lipid accumulation. ..
  53. Mitsugi R, Itoh T, Fujiwara R. Expression of Human DNAJ (Heat Shock Protein-40) B3 in Humanized UDP-glucuronosyltransferase 1 Mice. Int J Mol Sci. 2015;16:14997-5008 pubmed publisher
    ..humanized UDP-glucuronosyltransferase (UGT) 1 mice (hUGT1 mice) were developed, in which the introduced human UGT1 gene contained a gene encoding human DNAJB3...
  54. Ribalta C, Sanchez Hernandez J, Sole M. Hepatic biotransformation and antioxidant enzyme activities in Mediterranean fish from different habitat depths. Sci Total Environ. 2015;532:176-83 pubmed publisher
    ..carboxylesterases (CbEs), and the phase-II conjugation activities uridine diphosphate glucuronyltransferase (UDPGT) and glutathione S-transferase (GST). Moreover, some antioxidant enzyme activities, i.e...
  55. Liu X, Cao Y, Ran R, Dong P, Gonzalez F, Wu X, et al. New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases. Chemosphere. 2016;144:1966-72 pubmed publisher
    ..01), 45.6% (p < 0.01), and 48.8% (p < 0.01), respectively. 100 µM of DPhP inhibited the activity of UGT1A3, UGT1A6, and UGT1A9 by 81.8 (p < 0.001), 49.1% (p < 0.05), and 76.4% (p < 0.001), respectively...
  56. Li L, Ashikov A, Liu H, Griffith C, Bakker H, Doering T. Cryptococcus neoformans UGT1 encodes a UDP-Galactose/UDP-GalNAc transporter. Glycobiology. 2017;27:87-98 pubmed publisher
    ..The UDP-galactose transporter, Ugt1, was initially identified by homology to known UGTs and glycan composition analysis of ugt1Δ mutants...
  57. Zhao X, Ren X, Ren B, Luo Z, Zhu R. Life-cycle exposure to BDE-47 results in thyroid endocrine disruption to adults and offsprings of zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2016;48:157-167 pubmed publisher
    ..All exposures significantly up-regulated expression of tshß, pa8, ugt1 and tg and down-regulated ttr. Significant up-regulation of dio2 and crh was observed in the 10?g/L BDE-47 group...
  58. Vodret S, Bortolussi G, Jašprová J, Vitek L, Muro A. Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model. J Neuroinflammation. 2017;14:64 pubmed publisher
    ..Pharmacological modulation of the inflammatory pathway may be a potential intervention target to ameliorate neonatal lethality in Ugt1 -/- mice.
  59. Aono S, Yamada Y, Keino H, Hanada N, Nakagawa T, Sasaoka Y, et al. Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. Biochem Biophys Res Commun. 1993;197:1239-44 pubmed
    ..Our patient was homozygous for all defects and his parents and elder brother were heterozygous for all defective alleles. The findings suggest that the CN Type II is inherited as an autosomal recessive trait. ..
  60. Killard A, O Kennedy R, Bogan D. Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC. J Pharm Biomed Anal. 1996;14:1585-90 pubmed
    ..The method was very reliable and applicable for the direct determination of 7-hydroxycoumarin-glucuronide in an in-vitro metabolic assay. ..
  61. Urawa N, Kobayashi Y, Araki J, Sugimoto R, Iwasa M, Kaito M, et al. Linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms. Oncol Rep. 2006;16:801-6 pubmed
    ..studies have demonstrated the frequent co-existence of UGT1A1 *28 (-53 [TA]6>7) with other polymorphisms of UGT1A6 and UGT1A7...
  62. Yu B, Zheng Y, Alexander D, Morrison A, Coresh J, Boerwinkle E. Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet. 2014;10:e1004212 pubmed publisher
    ..These results highlight the value of using endophenotypes proximal to gene function to discover new insights into biology and disease pathology. ..
  63. Sakamoto M, Itoh T, Tukey R, Fujiwara R. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015;30:269-75 pubmed publisher
    ..In the present study, therefore, we investigated UGT mRNA expressions in brains of humanized UGT1 (hUGT1) mice. We found that among the human UGT1 members, UGT1A1, 1A3, and 1A6 were expressed in the brain...
  64. Sakakibara Y, Katoh M, Kondo Y, Nadai M. Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain. Drug Metab Dispos. 2016;44:370-7 pubmed publisher
    ..Here, we aimed to clarify the effects of PB on Ugt1a6 and Ugt1a7 gene expression in rat brains...
  65. Chen X, Wang Q, Liu N, Liu G, Chi Z, Chi Z. A glycosyltransferase gene responsible for pullulan biosynthesis in Aureobasidium melanogenum P16. Int J Biol Macromol. 2017;95:539-549 pubmed publisher
    ..It was found that the UGT1 gene had 4774bp with four introns (47, 52, 54 and 46bp)...
  66. Court M, Duan S, von Moltke L, Greenblatt D, Patten C, Miners J, et al. Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther. 2001;299:998-1006 pubmed
    ..Activities mediated by UGT1A1, UGT1A4, UGT1A9, and UGT2B7, and relative UGT1A6 protein content were quantified using 20 livers...
  67. Sakakibara Y, Katoh M, Kondo Y, Nadai M. Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain. Biol Pharm Bull. 2016;39:78-83 pubmed publisher
    ..to elucidate the effect of β-naphthoflavone (BNF), one of the major inducers of drug-metabolizing enzymes, on Ugt1a6 and Ugt1a7 mRNA expression and their glucuronidation in the rat brain...
  68. Wang J, Wang H, Peng Y, Wang G, Hao H. Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo. Chin J Nat Med. 2016;14:865-870 pubmed publisher
    ..25 ?mol·L-1 and Ki being 26.77 ?mol·L-1. In addition, ICQA inhibited UGT1A6 activity by 25%, in the mice treated with ICQA (i.p...
  69. van Oijen M, Huybers S, Peters W, Drenth J, Laheij R, Verheugt F, et al. Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid. Br J Clin Pharmacol. 2005;60:623-8 pubmed
    As acetylsalicylic acid is metabolized by UDP-glucuronosyltransferase 1A6 (UGT1A6) and cytochrome P450 2C9 (CYP2C9), interindividual differences in activity of these enzymes may modulate the effects and side-effects of acetylsalicylic ..
  70. Allegaert K, Verbesselt R, Rayyan M, Debeer A, de Hoon J. Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Methods Find Exp Clin Pharmacol. 2007;29:251-6 pubmed
    ..Urine metabolites to assess in vivo metabolism of drugs routinely administered in neonates likely increase both the feasibility and clinical relevance of studies on in vivo isoenzyme-specific ontogeny in neonates. ..
  71. Liu M, Chen S, Yueh M, Fujiwara R, Konopnicki C, Hao H, et al. Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016;110-111:37-46 pubmed publisher
    Humanized UDP-glucuronosyltransferase (UGT)-1 (hUGT1) mice encode the UGT1 locus including the UGT1A1 gene...
  72. Liu J, Yu X, Zhong S, Han W, Liang Z, Ye L, et al. Hepatic and renal metabolism of genistein: An individual-based model to predict glucuronidation behavior of genistein in different organs. J Pharm Biomed Anal. 2017;139:252-262 pubmed publisher
    ..Ten UDP-glucuronosyltransferases (UGTs) were expressed in liver abundantly. Among them, UGT1A1, UGT1A3, UGT1A6, UGT1A9 and UGT2B7 contributed 95...
  73. Xing Y, Yang L, Wang L, Shao L, Wei Z, Xuan J, et al. Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling. Pharmacogenomics. 2009;10:741-52 pubmed publisher
    To date, there have been relatively few studies on the UGT1A6 gene in the Chinese population...
  74. Samowitz W, Wolff R, Curtin K, Sweeney C, Ma K, Andersen K, et al. Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Clin Gastroenterol Hepatol. 2006;4:894-901 pubmed
    Variant genotypes of uridine diphosphate glucuronsyltransferase isoenzyme 1A6 (UGT1A6) associated with decreased metabolic activity have been associated with an enhanced protective effect of aspirin on the development of colorectal ..
  75. Sun Y, Yu J, Yuan Q, Wu X, Wu X, Hu J. Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury. Scand J Trauma Resusc Emerg Med. 2017;25:85 pubmed publisher
    ..Genetic polymorphisms in UGT1A6, UGT2B7, CYP2C9, and CYP2C19 were analyzed in association with daily VPA plasma concentrations, adjusted dosages, ..
  76. Zhang C, He Y, Shan K, Tan K, Zhang T, Wang C, et al. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China. J Int Med Res. 2017;:300060517730174 pubmed publisher
    ..The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5?32 [rs333]) and then characterized their ..
  77. Visscher H, Ross C, Rassekh S, Sandor G, Caron H, van Dalen E, et al. Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children. Pediatr Blood Cancer. 2013;60:1375-81 pubmed publisher
    ..We confirmed the association of rs17863783 in UGT1A6 and ACT in the replication cohort (P = 0.0062, odds ratio (OR) 7.98)...
  78. Veyhl J, Dunn R, Johnston W, Bennett A, Zhang L, Dennis J, et al. The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ß1,4-N-acetylgalactosaminyltransferase enzyme. PLoS ONE. 2017;12:e0183049 pubmed publisher
    ..We also found that the absence of the GnT1/Mgat1 activity [UDP-N-acetyl-D-glucosamine:?-3-D-mannoside ?-1,2-N-acetylglucosaminyltransferase 1 (encoded by C...
  79. Antonio L, Xu J, Little J, Burchell B, Magdalou J, Radominska Pandya A. Glucuronidation of catechols by human hepatic, gastric, and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9, and UGT2B7. Arch Biochem Biophys. 2003;411:251-61 pubmed
    ..Immunoblot analysis demonstrated the presence of UGT1A6 and UGT2B7 in stomach and throughout the intestine...
  80. Limenta L, Jirasomprasert T, Tankanitlert J, Svasti S, Wilairat P, Chantharaksri U, et al. UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers. Br J Clin Pharmacol. 2008;65:908-16 pubmed publisher
    b>UGT1A6 has been proposed as the predominant isoform responsible for the glucuronidation of deferiprone. UGT1A6*2 allele has been associated with the altered enzyme activity...
  81. Osawa K, Nakarai C, Akiyama M, Hashimoto R, Tsutou A, Takahashi J, et al. Association between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk. Asian Pac J Cancer Prev. 2012;13:2311-4 pubmed
    Genetic polymorphisms of uridine diphosphate-glucuronosyltransferases 1A6 (UGT1A6) and 1A7 (UGT1A7) may lead to genetic instability and colorectal cancer carcinogenesis...
  82. Aueviriyavit S, Furihata T, Morimoto K, Kobayashi K, Chiba K. Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers. Drug Metab Pharmacokinet. 2007;22:391-8 pubmed
    ..Among the UGT1A isoforms, UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9 are predominantly expressed in the liver...
  83. Bock K, Kohle C. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol. 2005;400:57-75 pubmed
    ..b>UGT1A6 is the founding member of the rat and human UGT1 family...
  84. Bellemare J, Rouleau M, Girard H, Harvey M, Guillemette C. Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab Dispos. 2010;38:1785-9 pubmed publisher
    ..In this study, we explored the potential of multiple active UGT1A_i1 proteins (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10) to interact with all spliced i2s by coimmunoprecipitation...
  85. Dai X, Wu C, He Y, Gui L, Zhou L, Guo H, et al. A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Genet Epidemiol. 2013;37:293-300 pubmed publisher
    ..Consistent associations and interactions were observed for serum direct and indirect bilirubin levels. ..
  86. Feng W, Mei S, Zhu L, Yu Y, Yang W, Gao B, et al. Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. Ther Drug Monit. 2016;38:738-743 pubmed
    ..07) software. A total of 111 children with epilepsy (80 responsive and 31 resistant) were enrolled. rs28898617 (UGT1A6, A > G) was associated with an increase in NCVPA (? = 5.31, 95% confidence interval = 0.78-9.83, P = 0...
  87. Fremont J, Wang R, King C. Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4. Mol Pharmacol. 2005;67:260-2 pubmed
    ..Solubilized human liver microsomes were incubated with specific antibodies to UGT2B7, UGT1A6, UGT1A1, and CYP3A4, and the immunoprecipitates were run on SDS-polyacrylamide gel electrophoresis...
  88. Ouzzine M, Barre L, Netter P, Magdalou J, Fournel Gigleux S. Role of the carboxyl terminal stop transfer sequence of UGT1A6 membrane protein in ER targeting and translocation of upstream lumenal domain. FEBS Lett. 2006;580:1953-8 pubmed
    We investigated the role of the stop transfer sequence of human UGT1A6 in ER assembly and enzyme activity...
  89. Hao J, Chen Y, Li S, Zhang P, Yu Y, Tang G, et al. [Relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury]. Zhonghua Gan Zang Bing Za Zhi. 2011;19:201-4 pubmed publisher
    To investigate the relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury (ADIH). 202 cases and 239 controls were collected and a case-control study was conducted...
  90. Kua L, Ross S, Lee S, Mimura K, Kono K, Goh B, et al. UGT1A6 polymorphisms modulated lung cancer risk in a Chinese population. PLoS ONE. 2012;7:e42873 pubmed publisher
    ..The purpose of this study was to evaluate the association of UGT1A6 polymorphisms and haplotypes with lung cancer risk and to evaluate the functional significance of UGT1A6 ..
  91. Kim Y, Lee C, Nan H, Kang J, Kim H. Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. J Occup Health. 2003;45:160-7 pubmed
    ..and to evaluate the effects of cigarette smoking and the genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, NAT2 and UGT1A6 on the relationship...
  92. Cox A, Ng M, Xu J, Langefeld C, Koch K, Dawson P, et al. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229:155-60 pubmed publisher
    ..These findings support a potential role for UGT1A genetic variants in risk for mortality in T2D. Further quantification of the extent of CVD risk conferred by UGT1A gene family variants in a high risk cohort with T2D is still required. ..