UGT1A10

Summary

Gene Symbol: UGT1A10
Description: UDP glucuronosyltransferase family 1 member A10
Alias: UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP-glucuronosyltransferase 1-10, UDP glucuronosyltransferase 1 family, polypeptide A10, UDP glycosyltransferase 1 family, polypeptide A10, UDP-glucuronosyltransferase 1-J, UDP-glucuronosyltransferase 1A10, UDPGT 1-10
Species: human
Products:     UGT1A10

Top Publications

  1. Lewinsky R, Smith P, Mackenzie P. Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships. Xenobiotica. 2005;35:117-29 pubmed
    The extrahepatic human UDP glucuronosyltransferase 1A10 is found throughout the gastrointestinal tract and is thought to participate in the removal of orally ingested lipophilic chemicals...
  2. Tukey R, Strassburg C. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000;40:581-616 pubmed
    ..The role of the UGTs in metabolism and different disease states in humans is the topic of this review. ..
  3. Sanna S, Busonero F, Maschio A, McArdle P, Usala G, Dei M, et al. Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet. 2009;18:2711-8 pubmed publisher
    ..Thus, SLC01B3 appears to be involved in the regulation of serum bilirubin levels in healthy individuals and in some bilirubin-related disorders that are only partially explained by other known gene variants. ..
  4. van Es H, Bout A, Liu J, Anderson L, Duncan A, Bosma P, et al. Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. Cytogenet Cell Genet. 1993;63:114-6 pubmed
    ..In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37. ..
  5. Johnson A, Kavousi M, Smith A, Chen M, Dehghan A, Aspelund T, et al. Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet. 2009;18:2700-10 pubmed publisher
    ..In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated. ..
  6. Kang T, Kim H, Ju H, Kim J, Jeon Y, Lee H, et al. Genome-wide association of serum bilirubin levels in Korean population. Hum Mol Genet. 2010;19:3672-8 pubmed publisher
    ..Our result supports the idea that there are considerable ethnic differences in genetic association of bilirubin levels between Koreans and European-derived populations. ..
  7. Strassburg C, Kneip S, Topp J, Obermayer Straub P, Barut A, Tukey R, et al. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem. 2000;275:36164-71 pubmed
    ..pattern of all the UGT genes was demonstrated in duodenal, jejunal, and ileal mucosa, with the exception of UGT1A10. To complement these studies, interindividual expression of UGT proteins and catalytic activities were also ..
  8. Laverdière I, Flageole C, Audet Walsh Ã, Caron P, Fradet Y, Lacombe L, et al. The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy. Endocr Relat Cancer. 2015;22:77-85 pubmed publisher
    ..59-1.88 (P<0.002) for htSNPs in UGT1A10, UGT1A9, and UGT1A6...
  9. Ismail S, Hanapi N, Ab Halim M, Uchaipichat V, Mackenzie P. Effects of Andrographis paniculata and Orthosiphon stamineus extracts on the glucuronidation of 4-methylumbelliferone in human UGT isoforms. Molecules. 2010;15:3578-92 pubmed publisher
    ..glucuronidation of 4-methylumbelliferone (4MU) by recombinant human UGTs, UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A10, UGT2B7 and UGT2B15 were determined...

More Information

Publications101 found, 100 shown here

  1. Kutsukake T, Furukawa Y, Ondo K, Gotoh S, Fukami T, Nakajima M. Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences. Drug Metab Dispos. 2019;47:38-44 pubmed publisher
    ..The difference between sexes was remarkable with regard to hepatic Ugt1a10 in any of the strains, although slight differences between sexes were also observed in multiple Ugt isoforms...
  2. Mubarokah N, Hulin J, Mackenzie P, McKinnon R, Haines A, Hu D, et al. Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element. Mol Pharmacol. 2018;93:541-552 pubmed publisher
    ..The expression of UGT1A8, UGT1A9, and UGT1A10 in gastrointestinal tissues is known to be at least partly directed by the caudal homeodomain transcription ..
  3. Ehmer U, Vogel A, Schütte J, Krone B, Manns M, Strassburg C. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology. 2004;39:970-7 pubmed
    ..128 patients with HCC, 235 blood donors) was analyzed for polymorphisms of the UGT1A3, UGT1A4, UGT1A8, UGT1A9, UGT1A10 genes using polymerase chain reaction, sequencing analysis...
  4. Kwon S, Kim J, Jeong H, Ahn K, Oh S, Lee H. Role of cytochrome P450 and UDP-glucuronosyltransferases in metabolic pathway of homoegonol in human liver microsomes. Drug Metab Pharmacokinet. 2015;30:305-13 pubmed publisher
    ..Glucuronidation of homoegonol to M5 was mediated by UGT1A1, UGT1A3, UGT1A4, and UGT2B7 enzymes, whereas M4 was formed from 4-O-demethylhomoegonol by UGT1A1, UGT1A8, UGT1A10, and UGT2B15 enzymes.
  5. Oda S, Fujiwara R, Kutsuno Y, Fukami T, Itoh T, Yokoi T, et al. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metab Dispos. 2015;43:812-8 pubmed publisher
    ..assessed inhibitory effects of 578 compounds, including drugs, xenobiotics, and endobiotics, on human UGT1A8 and UGT1A10, which are major contributors to intestinal glucuronidation...
  6. Li L, Huang X, Peng J, Zheng M, Zhong D, Zhang C, et al. Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As). Phytomedicine. 2016;23:340-9 pubmed publisher
    ..Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides...
  7. Richter L, Kaminski Y, Noor F, Meyer M, Maurer H. Metabolic fate of desomorphine elucidated using rat urine, pooled human liver preparations, and human hepatocyte cultures as well as its detectability using standard urine screening approaches. Anal Bioanal Chem. 2016;408:6283-94 pubmed publisher
    ..UDP-glucuronyltransferase (UGT) initial activity screening showed that UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B15, and UGT2B17 formed desomorphine glucuronide...
  8. Olufsen M, Arukwe A. Endocrine, biotransformation, and oxidative stress responses in salmon hepatocytes exposed to chemically induced hypoxia and perfluorooctane sulfonamide (PFOSA), given singly or in combination. Environ Sci Pollut Res Int. 2015;22:17350-66 pubmed publisher
    ..data show that transcript levels for endocrine (ERα, Vtg, and Zrp), biotransformation (cyp1a, cyp3a, gst, and udpgt), and oxidative stress responses (catalase (cat), glutathione peroxidase (gpx), and glutathione reductase (gr)) ..
  9. Gufford B, Chen G, Vergara A, Lazarus P, Oberlies N, Paine M. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction. Drug Metab Dispos. 2015;43:1353-9 pubmed publisher
    ..using human intestinal microsomes and human embryonic kidney cell lysates overexpressing UGT1A1, UGT1A8, and UGT1A10, isoforms highly expressed in the intestine that are critical to raloxifene clearance...
  10. Pattanawongsa A, Chau N, Rowland A, Miners J. Inhibition of Human UDP-Glucuronosyltransferase Enzymes by Canagliflozin and Dapagliflozin: Implications for Drug-Drug Interactions. Drug Metab Dispos. 2015;43:1468-76 pubmed publisher
    ..CNF inhibited all UGT1A subfamily enzymes, but the greatest inhibition was observed with UGT1A1, UGT1A9, and UGT1A10 (IC50 values ≤ 10 µM)...
  11. Solé M, Fortuny A, Mañanós E. Effects of selected xenobiotics on hepatic and plasmatic biomarkers in juveniles of Solea senegalensis. Environ Res. 2014;135:227-35 pubmed publisher
    ..reductases, carboxylesterases (CbEs) and the conjugation enzyme uridine diphosphate glucuronyltransferase (UDPGT)...
  12. Lapham K, Lin J, Novak J, Orozco C, Niosi M, Di L, et al. 6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol. Drug Metab Dispos. 2018;46:1836-1846 pubmed publisher
    ..intestinal microsomes, where ES overestimated the RAF of UGT1A1 due to glucuronidation by intestinal UGT1A8 and UGT1A10. Our results suggest the potential utility of PF-06409477 as a selective probe UGT1A1 substrate for UGT reaction ..
  13. Kim J, Hwang D, Moon J, Lee Y, Yoo J, Shin D, et al. Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations. Molecules. 2017;22: pubmed publisher
    ..was catalyzed by commonly expressed UGT1A1 and UGT1A9 and gastrointestinal-specific UGT1A7, UGT1A8, and UGT1A10, consistent with the higher intrinsic clearance values for the formation of M1, M2, M6, and <..
  14. Operaña T, Tukey R. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007;282:4821-9 pubmed
    ..This technique demonstrated that UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 self-oligomerize (homodimerize)...
  15. Dunnick J, Nyska A. Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers. Exp Toxicol Pathol. 2009;61:1-12 pubmed publisher
    ..Treatment-related increases in liver weights, liver cytochrome P450 (1A1, 1A2, 2B) and UDPGT (rats only) levels, and liver lesions were seen in both rats and mice...
  16. Troberg J, Järvinen E, Muniz M, Sneitz N, Mosorin J, Hagström M, et al. Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity. Drug Metab Dispos. 2015;43:107-18 pubmed publisher
    ..The results revealed similarities but also many differences. For example, similarly to the human UGT1A10, dUGT1A11 exhibited high glucuronidation activity toward the 3-OH of 17-β-estradiol, 17-α-estradiol, and ..
  17. Kotze A, Ruffell A, Ingham A. Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae. Antimicrob Agents Chemother. 2014;58:7475-83 pubmed publisher
    ..The phenobarbital-induced drug tolerance was reversed by cotreatment with the UDPGT inhibitors 5-nitrouracil, 4,6-dihydroxy-5-nitropyrimidine, probenecid, and sulfinpyrazone...
  18. Cengiz B, Yumrutas O, Bozgeyik E, Borazan E, Igci Y, Bozgeyik I, et al. Differential expression of the UGT1A family of genes in stomach cancer tissues. Tumour Biol. 2015;36:5831-7 pubmed publisher
    ..Accordingly, UGT1A1, UGT1A8, and UGT1A10 were found to be upregulated, and UGT1A3, UGT1A5, UGT1A7, and UGT1A9 were downregulated in stomach tumors...
  19. Liu D, Li S, Qi J, Meng D, Cao Y. The inhibitory effects of nor-oleanane triterpenoid saponins from Stauntonia brachyanthera towards UDP-glucuronosyltransferases. Fitoterapia. 2016;112:56-64 pubmed publisher
    ..compounds, 2, 3, 4, 8, 9, 13 and 14, respectively, exhibited potential inhibitions towards UGT1A1, UGT1A3 and UGT1A10 among all 23 compounds isolated from the plants. The IC50 values were 17.1?M, 13.5?M, 9.5?M, 15.7?M, 16.3?M, 1...
  20. Kim K, Zheng F, Zhan C. Oligomerization and Catalytic Parameters of Human UDP-Glucuronosyltransferase 1A10: Expression and Characterization of the Recombinant Protein. Drug Metab Dispos. 2018;46:1446-1452 pubmed publisher
    ..Most UGTs are expressed in liver, but UGT1A10 has proven to be an extrahepatic enzyme considerably expressed throughout the gastrointestinal tract...
  21. Xie Z, Li T, Gan B, Gao X, Gao L, Chen G, et al. Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysis. Pathol Res Pract. 2018;214:644-654 pubmed publisher
    ..Seven hub genes (UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A10, SRD5A1, and ADH7) were found to be upregulated, and UGT1A1, UGT1A3, UGT1A6, UGT1A7, and ADH7 were negatively ..
  22. Ramírez J, Mirkov S, House L, Ratain M. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10. Drug Metab Dispos. 2015;43:928-35 pubmed publisher
    ..exhibited the highest intrinsic clearances (CLint) for OTS167, followed by UGT1A3 (51 µl/min/mg) and UGT1A10 (47 µl/min/mg); UGT1A9 was a minor contributor...
  23. Uno Y, Takahira R, Murayama N, Ishii Y, Ikenaka Y, Ishizuka M, et al. Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques. Biochem Pharmacol. 2018;155:172-181 pubmed publisher
    ..Among these 11 cynomolgus UGT1A mRNAs, cynomolgus UGT1A2, UGT1A9, and UGT1A10 mRNAs were most abundantly expressed in the liver, kidney, and jejunum, respectively...
  24. Lv X, Wang X, Hou J, Fang Z, Wu J, Cao Y, et al. Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases. Toxicol Appl Pharmacol. 2016;301:42-9 pubmed publisher
    ..demonstrated that both tolcapone and entacapone exhibited inhibitory effects on UGT1A1, UGT1A7, UGT1A9 and UGT1A10. In contrast to entacapone, tolcapone exhibited more potent inhibitory effects on UGT1A1, UGT1A7, and UGT1A10, ..
  25. He Y, Folkerts E, Zhang Y, Martin J, Alessi D, Goss G. Effects on Biotransformation, Oxidative Stress, and Endocrine Disruption in Rainbow Trout (Oncorhynchus mykiss) Exposed to Hydraulic Fracturing Flowback and Produced Water. Environ Sci Technol. 2017;51:940-947 pubmed publisher
    ..The increased expression of cyp1a (2.49 ± 0.28-fold), udpgt (2.01 ± 0.31-fold), sod (1.67 ± 0.09-fold), and gpx (1.58 ± 0.10-fold) in raw sample exposure group (7...
  26. Benton M, Lea R, Macartney Coxson D, Bellis C, Carless M, Curran J, et al. Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate. BMC Genet. 2015;16:136 pubmed publisher
    ..GWAS of blood-based clinical traits in the Norfolk Island population has identified variants within the UDPGT family directly associated with serum bilirubin levels, which is in turn implicated with reduced risk of ..
  27. Crespo M, Sole M. The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system. Environ Sci Pollut Res Int. 2016;23:19229-36 pubmed publisher
    ..and BFCOD, carboxylesterase (CbE), glutathione S-transferase (GST) and uridine diphosphate glucuronyltransferase (UDPGT); and oxidative stress parameters such as catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (..
  28. González Mira A, Varo I, Sole M, Torreblanca A. Drugs of environmental concern modify Solea senegalensis physiology and biochemistry in a temperature-dependent manner. Environ Sci Pollut Res Int. 2016;23:20937-20951 pubmed
    ..BFCOD)) and uridine diphosphate glucuronosyltransferase (UDPGT)...
  29. He G, Troberg J, Lv X, Xia Y, Zhu L, Ning J, et al. Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation. Xenobiotica. 2018;48:109-116 pubmed publisher
    ..3.?Reaction phenotyping with 12 commercial recombinant human UGTs, as well as with the Helsinki laboratory UGT1A10 that carry a C-terminal His-tag (UGT1A10-H), revealed that UGT1A10-H catalyzes xanthotoxol glucuronidation at the ..
  30. Oda S, Kato Y, Hatakeyama M, Iwamura A, Fukami T, Kume T, et al. Evaluation of expression and glycosylation status of UGT1A10 in Supersomes and intestinal epithelial cells with a novel specific UGT1A10 monoclonal antibody. Drug Metab Dispos. 2017;45:1027-1034 pubmed publisher
    ..Earlier studies have reported that human UGT1A10 is expressed in the gastrointestinal tract at the mRNA level, but the evaluation at the protein level, especially ..
  31. Hanioka N, Kinashi Y, Tanaka Kagawa T, Isobe T, Jinno H. Glucuronidation of mono(2-ethylhexyl) phthalate in humans: roles of hepatic and intestinal UDP-glucuronosyltransferases. Arch Toxicol. 2017;91:689-698 pubmed publisher
    ..Among the recombinant UGTs examined, UGT1A3, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, and UGT2B7 glucuronidated MEHP...
  32. Liao M, Gao C, Phillips B, Neradugomma N, Han L, Bhatt D, et al. Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation. Drug Metab Dispos. 2018;46:100-108 pubmed publisher
    ..consideration of the increase in liver protein content and liver weight, we found that the amounts of Ugt1a1, Ugt1a10, Ugt2b1, and Ugt2b35 protein in the whole liver of pregnant mice were significantly increased ∼2-fold compared ..
  33. Du Z, Cao Y, Li S, Hu C, Fu Z, Huang C, et al. Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters. Chemosphere. 2018;197:7-13 pubmed publisher
    ..phthalate monoesters exhibited negligible inhibition towards the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A10, UGT2B4, UGT2B7, UGT2B15 and UGT2B17...
  34. Berkhout M, Roelofs H, te Morsche R, Dekker E, van Krieken J, Nagengast F, et al. Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. Br J Surg. 2008;95:499-505 pubmed
    ..glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs): UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A10, UGT2B4, UGT2B7, UGT2B15, GSTA1, GSTP1, GSTM1 and GSTT1...
  35. Ribalta C, Sanchez Hernandez J, Sole M. Hepatic biotransformation and antioxidant enzyme activities in Mediterranean fish from different habitat depths. Sci Total Environ. 2015;532:176-83 pubmed publisher
    ..carboxylesterases (CbEs), and the phase-II conjugation activities uridine diphosphate glucuronyltransferase (UDPGT) and glutathione S-transferase (GST). Moreover, some antioxidant enzyme activities, i.e...
  36. Hoydal K, Jenssen B, Letcher R, Dam M, Arukwe A. Hepatic phase I and II biotransformation responses and contaminant exposure in long-finned pilot whales from the Northeastern Atlantic. Mar Environ Res. 2018;134:44-54 pubmed publisher
    ..The activity levels of phase II conjugating enzymes (uridine 5'-diphospho-glucuronosyltransferase [UDPGT], and glutathione S-transferase [GST]) were low...
  37. Bao L, Zhang Y, Wang J, Wang H, Dong N, Su X, et al. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer. Cell Biol Toxicol. 2016;32:419-35 pubmed publisher
    ..HOXD3, HOXD4, HOXD8, and HOXD9) and UGT1A family (UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A7, UGT1A8, UGT1A9, and UGT1A10); and LCC- or SCLC-specific genes were also identified...
  38. Brand W, Boersma M, Bik H, Hoek van den Hil E, Vervoort J, Barron D, et al. Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab Dispos. 2010;38:617-25 pubmed publisher
    ..Furthermore, UGT1A6 and UGT2B4 only produce hesperetin 7-O-glucuronide, whereas UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B15 conjugate both positions...
  39. Yu B, Zheng Y, Alexander D, Morrison A, Coresh J, Boerwinkle E. Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet. 2014;10:e1004212 pubmed publisher
    ..These results highlight the value of using endophenotypes proximal to gene function to discover new insights into biology and disease pathology. ..
  40. Joseph T, Wang S, Liu X, Kulkarni K, Wang J, Xu H, et al. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm. 2007;4:883-94 pubmed
    ..UGT1A7, UGT1A8, and UGT1A9 were mainly responsible for the formation of metabolite 1, whereas UGT1A1, UGT1A8, and UGT1A10 were mainly responsible for the formation of metabolite 2...
  41. Shiraga T, Yajima K, Suzuki K, Suzuki K, Hashimoto T, Iwatsubo T, et al. Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine. Drug Metab Dispos. 2012;40:276-82 pubmed publisher
    ..All other UGT isoforms were inactive toward darexaban. The K(m) value of recombinant UGT1A10 for darexaban glucuronidation (34.2 ?M) was comparable to that of HIM...
  42. Xiong Y, Bernardi D, Bratton S, Ward M, Battaglia E, Finel M, et al. Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis. Biochemistry. 2006;45:2322-32 pubmed
    ..1A family for their ability to glucuronidate p-nitrophenol (pNP) and 4-methylumbelliferone (4-MU) revealed that UGT1A10 shows high activity toward phenols and phenol derivatives...
  43. Balliet R, Chen G, Dellinger R, Lazarus P. UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility. Drug Metab Dispos. 2010;38:484-90 pubmed publisher
    The extrahepatic UDP-glucuronosyltransferase 1A10 (UGT1A10) is a phase II metabolizing enzyme that is active against a number of potent carcinogens...
  44. Itäaho K, Laakkonen L, Finel M. How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?. Drug Metab Dispos. 2010;38:687-96 pubmed publisher
    ..glucuronidation, and the glucuronidation rate of alpha- and beta-estradiol differ greatly between UGT1A9 and UGT1A10. To identify the residue responsible for the activity differences, we divided the N-terminal half of the two UGTs ..
  45. Basu N, Kubota S, Meselhy M, Ciotti M, Chowdhury B, Hartori M, et al. Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. J Biol Chem. 2004;279:28320-9 pubmed
    Among gastrointestinal distributed isozymes encoded at the UGT1 locus, UDP-glucuronosyltransferase 1A10 (UGT1A10) metabolizes a number of important chemicals. Similar to broad conversion of phytoestrogens (Basu, N. K., Ciotti, M...
  46. Mick E, Todorov A, Smalley S, Hu X, Loo S, Todd R, et al. Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010;49:898-905.e3 pubmed publisher
    ..We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders. ..
  47. Jylhävä J, Lyytikäinen L, Kahonen M, Hutri Kähönen N, Kettunen J, Viikari J, et al. A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study. PLoS ONE. 2012;7:e35426 pubmed publisher
    ..These data indicate that UGT1A1-associated processes are also involved in the regulation of serum cf-DNA concentrations. ..
  48. Li X, Bratton S, Radominska Pandya A. Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes. Drug Metab Pharmacokinet. 2007;22:152-61 pubmed
    ..The discovery of these isoforms in hepatocytes is a novel discovery and will stimulate studies on the potential role for these isoforms in hepatic detoxification. ..
  49. Fedejko Kap B, Bratton S, Finel M, Radominska Pandya A, Mazerska Z. Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10. Drug Metab Dispos. 2012;40:1736-43 pubmed publisher
    ..Recombinant extrahepatic UGT1A10 glucuronidated 8-hydroxyl groups with the highest catalytic efficiency compared with other recombinant UGTs, V(..
  50. DISTEFANO J, Kingsley C, Craig Wood G, Chu X, Argyropoulos G, Still C, et al. Genome-wide analysis of hepatic lipid content in extreme obesity. Acta Diabetol. 2015;52:373-82 pubmed publisher
    ..These results replicate findings for several hepatic phenotypes in the setting of extreme obesity and implicate new loci that may play a role in the pathophysiology of hepatic lipid accumulation. ..
  51. Kallionpää R, Järvinen E, Finel M. Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7. J Steroid Biochem Mol Biol. 2015;154:104-11 pubmed publisher
    ..The results revealed that UGT1A10 is by far the most active enzyme in estrone glucuronidation...
  52. Saeki M, Ozawa S, Saito Y, Jinno H, Hamaguchi T, Nokihara H, et al. Three novel single nucleotide polymorphisms in UGT1A10. Drug Metab Pharmacokinet. 2002;17:488-90 pubmed
    ..The detected SNPs were as follows: 1) SNP, MPJ6_U1A003; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CAGATGCCATGAC/TTTTCAAGGAGAG-3'...
  53. Oda S, Fukami T, Yokoi T, Nakajima M. Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10. Biochem Pharmacol. 2014;87:660-7 pubmed publisher
    Human UDP-glucuronosyltransferase (UGT) 1A10 is not expressed in the liver; however, UGT1A10 is highly expressed in the intestine, contributing to presystemic first-pass metabolism...
  54. Elahi A, Bendaly J, Zheng Z, Muscat J, Richie J, Schantz S, et al. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. Cancer. 2003;98:872-80 pubmed
    b>UGT1A10 exhibits glucuronidating activity against metabolites of the tobacco smoke carcinogen, benzo(a)pyrene, and is expressed highly in numerous target tissues for tobacco-related cancers including the upper aerodigestive tract...
  55. Manevski N, Kurkela M, Höglund C, Mauriala T, Court M, Yli Kauhaluoma J, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010;38:386-95 pubmed publisher
    ..b>UGT1A10 exhibited the highest psilocin glucuronidation activity, whereas the activities of UGTs 1A9, 1A8, 1A7, and 1A6 ..
  56. Chen G, Ramos E, Adeyemo A, Shriner D, Zhou J, Doumatey A, et al. UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet. 2012;20:463-8 pubmed publisher
    ..In summary, UGT1A1 is a major locus influencing bilirubin levels and the results of this study promise to contribute to understanding of the etiology and treatment of hyperbilirubinaemia in African-ancestry populations. ..
  57. Gregory P, Gardner Stephen D, Lewinsky R, Duncliffe K, Mackenzie P. Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region. J Biol Chem. 2003;278:36107-14 pubmed
    ..These results provide evidence that the UGT1A8, 1A9, and 1A10 genes are differentially regulated through an initiator element in their 5'-flanking regions. ..
  58. Milton J, Sebastiani P, Solovieff N, Hartley S, Bhatnagar P, Arking D, et al. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS ONE. 2012;7:e34741 pubmed publisher
    ..SNPs in UGT1A1, UGT1A3, UGT1A6, UGT1A8 and UGT1A10, different isoforms within the UGT1A locus, were identified (most significant rs887829, p = 9.08 × 10(-25))...
  59. Rowbotham S, Illingworth N, Daly A, Veal G, Boddy A. Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans. Drug Metab Dispos. 2010;38:1211-7 pubmed publisher
    ..Therefore, UGT1A9 is likely to be the most important enzyme in the glucuronidation of both substrates as this enzyme had the lowest K(m) and is expressed in both the intestine and at high levels in the liver...
  60. Mackenzie P, Owens I, Burchell B, Bock K, Bairoch A, Belanger A, et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics. 1997;7:255-69 pubmed
    ..g. UGT1A1*30) consistent with the Human Gene Nomenclature Guidelines. It is anticipated that this UGT gene nomenclature system will require updating on a regular basis. ..
  61. Tang L, Platek M, Yao S, Till C, Goodman P, Tangen C, et al. Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Carcinogenesis. 2017;: pubmed publisher
    ..polymorphisms (SNPs) in 13 genes (PGR, ESR1, ESR2, CYP17A1, HSD17B1, CYP19A1, CYP1A1, CYP1B1,COMT, UGT1A6, UGT1A10, UGT2B7, UGT2B15) were examined in whites only...
  62. Gong Q, Cho J, Huang T, Potter C, Gholami N, Basu N, et al. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics. 2001;11:357-68 pubmed
    ..The mRNAs are differentially expressed in hepatic and extrahepatic tissues. This locus is indeed novel, indicating the least usage of exon sequences in specifying different transferase isozymes that have an expansive substrate range. ..
  63. Banerjee R, Pennington M, Garza A, Owens I. Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence. Biochemistry. 2008;47:7385-92 pubmed publisher
    ..Among predicted binding sites N292, K314, K315, and K404 in UGT1A10, two informative sets of mutants K314R/Q/A/E/G and K404R/E had null activities or 2...
  64. Miller G, Lichti C, Zielinska A, Mazur A, Bratton S, Gallus Zawada A, et al. Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin. Drug Metab Dispos. 2008;36:2211-8 pubmed publisher
    ..e., 6-, 7-, and 8-hydroxywarfarin). This study expands on this finding by testing the hypothesis that the UGT1A10 F(90)-M(91)-V(92)-F(93) amino acid motif is important for proper recognition and conjugation of hydroxywarfarin ..
  65. Figueroa J, Ye Y, Siddiq A, Garcia Closas M, Chatterjee N, Prokunina Olsson L, et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet. 2014;23:1387-98 pubmed publisher
  66. Strassburg C, Oldhafer K, Manns M, Tukey R. Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol. 1997;52:212-20 pubmed
    ..expressed UGT1A1 and UGT1A4 but hepatocellular tissue uniquely expressed UGT1A9, whereas biliary tissue expressed UGT1A10. In contrast to hepatocellular tissue, gastric tissue expressed UGT1A7 in addition to UGT1A10...
  67. Tang L, Ye L, Singh R, Wu B, Lv C, Zhao J, et al. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm. 2010;7:664-79 pubmed publisher
    ..The results also indicated that UGT1A1, UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2B7 are the most important six UGT isoforms for metabolizing the chosen flavones...
  68. Hong M, Karlsson R, Magnusson P, Lewis M, Isaacs W, Zheng L, et al. A genome-wide assessment of variability in human serum metabolism. Hum Mutat. 2013;34:515-24 pubmed publisher
    ..mQTL SNPs and mQTL-harboring genes were over-represented across GWASs conducted to date, suggesting that these data may have utility in tracing the molecular basis of some complex disease associations. ..
  69. Blevins Primeau A, Sun D, Chen G, Sharma A, Gallagher C, Amin S, et al. Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009;69:1892-900 pubmed publisher
    ..Little or no difference in TAM glucuronidating activity was observed for the UGT1A8(173Gly/277Cys) or UGT1A10(139Lys) variants compared with their wild-type counterparts...
  70. Cox A, Ng M, Xu J, Langefeld C, Koch K, Dawson P, et al. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229:155-60 pubmed publisher
    ..These findings support a potential role for UGT1A genetic variants in risk for mortality in T2D. Further quantification of the extent of CVD risk conferred by UGT1A gene family variants in a high risk cohort with T2D is still required. ..
  71. Qu W, Liu X. Identification of Cytochrome P450 (CYP) isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction (DDI). Biomed Chromatogr. 2017;: pubmed publisher
    ..Artocarpin showed strong inhibition against UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, CYP2C8 and CYP3A4...
  72. Harding D, Jeremiah S, Povey S, Burchell B. Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1. Ann Hum Genet. 1990;54:17-21 pubmed
    ..The results indicate that this UDP-glucuronosyltransferase is encoded by a single gene, designated GNT1, located on human chromosome 2. ..
  73. Gramec Skledar D, Troberg J, Lavdas J, Peterlin Mašič L, Finel M. Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10. Xenobiotica. 2015;45:511-9 pubmed publisher
    ..results revealed that UGT1A9, primarily a hepatic enzyme, is mainly responsible for BPS glucuronidation, whereas UGT1A10, an intestine enzyme that is highly homologous to UGT1A9 at the protein level, is by far the most active UGT in ..
  74. King C, Rios G, Green M, Tephly T. UDP-glucuronosyltransferases. Curr Drug Metab. 2000;1:143-61 pubmed
    ..This review discusses the two UGT gene families, substrate specificities, and the recent discoveries of UGTs in extrahepatic tissues. ..
  75. Mojarrabi B, Mackenzie P. Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon. Biochem Biophys Res Commun. 1998;247:704-9 pubmed
    ..The cDNA encoding these two forms, UGT1A8 and UGT1A10, was synthesized and expressed in COS-7 cells...
  76. Basu N, Kole L, Basu M, Chakraborty K, Mitra P, Owens I. The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J Biol Chem. 2008;283:23048-61 pubmed publisher
  77. Bielinski S, Chai H, Pathak J, Talwalkar J, Limburg P, Gullerud R, et al. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. Mayo Clin Proc. 2011;86:606-14 pubmed publisher
    ..The MayoGC provides a model of a unique collaborative effort in the environment of a common EMR for the investigation of genetic determinants of diseases. ..
  78. Höglund C, Sneitz N, Radominska Pandya A, Laakonen L, Finel M. Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens. Steroids. 2011;76:1465-73 pubmed publisher
    ..In order to further understand and extend our earlier findings with phenylalanines 90 and 93 of UGT1A10, we have replaced each of them with Gly, Ala, Val, Leu, Ile or Tyr, and tested the activity of the resulting 12 ..
  79. Tukey R, Strassburg C. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol. 2001;59:405-14 pubmed
    ..In addition, tools have now been developed and examples presented to identify the expression patterns of the UGTs in human tissues, paying particular attention to expression patterns of these genes in the hepato-gastrointestinal tract. ..
  80. Minami H, Sai K, Saeki M, Saito Y, Ozawa S, Suzuki K, et al. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenet Genomics. 2007;17:497-504 pubmed
  81. Zheng Z, Fang J, Lazarus P. Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Drug Metab Dispos. 2002;30:397-403 pubmed
    ..By semiquantitative duplex reverse transcription-polymerase chain reaction analysis, UGT1A7 and UGT1A10 were shown to be well expressed in all aerodigestive tract tissues examined, including tongue, tonsil, floor of ..
  82. Bellemare J, Rouleau M, Girard H, Harvey M, Guillemette C. Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab Dispos. 2010;38:1785-9 pubmed publisher
    ..the potential of multiple active UGT1A_i1 proteins (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10) to interact with all spliced i2s by coimmunoprecipitation...
  83. Rothman N, Garcia Closas M, Chatterjee N, Malats N, Wu X, Figueroa J, et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010;42:978-84 pubmed publisher
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. ..
  84. Kahma H, Filppula A, Neuvonen M, Tarkiainen E, Tornio A, Holmberg M, et al. Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions . Drug Metab Dispos. 2018;46:141-150 pubmed publisher
    ..Of other enzymes displaying activity (UGT1A3, UGT1A9, UGT1A10-H, and UGT2B4), UGT2B4 (CLint,u 0...
  85. Dai X, Wu C, He Y, Gui L, Zhou L, Guo H, et al. A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Genet Epidemiol. 2013;37:293-300 pubmed publisher
    ..Consistent associations and interactions were observed for serum direct and indirect bilirubin levels. ..
  86. Lu J, Zhang Y, Li H, Yu J, Liu S. Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage. Chem Commun (Camb). 2014;50:13896-9 pubmed publisher
  87. Mojarrabi B, Mackenzie P. The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid. Biochem Biophys Res Commun. 1997;238:775-8 pubmed
    The cDNA encoding the UDP glucuronosyltransferase, UGT1A10, has been cloned from human colon...
  88. Cheng Z, Radominska Pandya A, Tephly T. Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10. Drug Metab Dispos. 1999;27:1165-70 pubmed
    ..mRNAs of UGT1A8 and UGT1A10 were detected in both the small intestine and the colon...
  89. Strassburg C, Strassburg A, Nguyen N, Li Q, Manns M, Tukey R. Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem J. 1999;338 ( Pt 2):489-98 pubmed
    ..by duplex reverse transcriptase-PCR analysis and revealed the expression of UGT1A7, UGT1A8, UGT1A9 and UGT1A10 mRNAs. UGT1A1, UGT1A3, UGT1A4, UGT1A5 and UGT1A6 transcripts were not detected...
  90. Cao Y, Du Z, Zhu Z, Sun H, Fu Z, Yang K, et al. Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes. Chemosphere. 2017;185:983-990 pubmed publisher
    ..PAEs exhibited no significant inhibition of UGT1A1, UGT1A3, UGT1A8, UGT1A10, UGT2B15, and UGT2B17, and limited inhibition of UGT1A6, UGT1A7 and UGT2B4...
  91. Jinno H, Saeki M, Tanaka Kagawa T, Hanioka N, Saito Y, Ozawa S, et al. Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos. 2003;31:528-32 pubmed
    ..We have previously reported two nonsynonymous single nucleotide polymorphisms in exon 1 of human UGT1A10 gene; 177G>A and 605C>T resulting in amino acid alterations, M59I and T202I, respectively...
  92. Pawlowska M, Chu R, Fedejko Kap B, Augustin E, Mazerska Z, Radominska Pandya A, et al. Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use. Drug Metab Dispos. 2013;41:414-21 pubmed publisher
    ..by several uridine diphosphate-glucuronyltransferase (UGT) isoforms, the most active being extrahepatic UGT1A10. The present studies were designed to test the ability and selectivity of UGT1A10 in the glucuronidation of ..